Cystine (BioDeep_00000014856)
Main id: BioDeep_00000398127
Secondary id: BioDeep_00000403028
human metabolite blood metabolite
代谢物信息卡片
2-amino-3-[(2-amino-2-carboxyethyl)disulfanyl]propanoic acid
化学式: C6H12N2O4S2 (240.02384719999998)
中文名称: DL-胱氨酸, L-胱氨酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C(C(C(=O)O)N)SSCC(C(=O)O)N
InChI: InChI=1S/C6H12N2O4S2/c7-3(5(9)10)1-13-14-2-4(8)6(11)12/h3-4H,1-2,7-8H2,(H,9,10)(H,11,12)
描述信息
Flavouring ingredient. (±)-Cystine is found in many foods, some of which are green bell pepper, green zucchini, italian sweet red pepper, and red bell pepper.
同义名列表
20 个代谢物同义名
2-amino-3-[(2-amino-2-carboxyethyl)disulfanyl]propanoic acid; α-Diamino-β-dithiolactic acid; alpha-Diamino-beta-dithiolactic acid; 3,3-Dithiobis(2-aminopropanoic acid); 3,3-Dithiobis(2-aminopropanoate); alpha-Diamino-beta-dithiolactate; a-Diamino-b-dithiolactic acid; Α-diamino-β-dithiolactic acid; Α-diamino-β-dithiolactate; a-Diamino-b-dithiolactate; Copper cystinate; (±)-Cystine; DL-Cystine; Dicysteine; L Cystine; L-Cystine; Cystine; Cistina; Zystin; Cystin
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:17376
- KEGG: C01420
- PubChem: 595
- HMDB: HMDB0250712
- Metlin: METLIN63635
- ChEMBL: CHEMBL366563
- Wikipedia: Cystine
- MeSH: Cystine
- foodb: FDB012672
- CAS: 4746-38-7
- CAS: 923-32-0
- CAS: 56-89-3
- PubChem: 4607
- NIKKAJI: J237.163D
- RefMet: Cystine
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Zhuoqun Li, Lixing Cao, Kai Han, Lihong Fan, Chong Zhao, Shutao Yin, Hongbo Hu. Non-cytotoxic nanomolar concentration of arctigenin protects neuronal cells from chemotherapy-induced ferroptosis by regulating SLC7A11-cystine-cysteine axis.
Biochemical and biophysical research communications.
2024 May; 710(?):149895. doi:
10.1016/j.bbrc.2024.149895. [PMID: 38593620] - Lin Zhang, Wen-Yao Shi, Jia-Ying Xu, Yan Liu, Shi-Jia Wang, Jia-Yang Zheng, Yun-Hong Li, Lin-Xi Yuan, Li-Qiang Qin. Protective effects and mechanism of chemical- and plant-based selenocystine against cadmium-induced liver damage.
Journal of hazardous materials.
2024 Apr; 468(?):133812. doi:
10.1016/j.jhazmat.2024.133812. [PMID: 38368684] - Chenfeng Han, Minmin Ge, Pengfei Xing, Tian Xia, Cangang Zhang, Kaili Ma, Yifu Ma, Shicheng Li, Wenhui Li, Xiaowei Liu, Baojun Zhang, Liyuan Zhang, Lianjun Zhang. Cystine deprivation triggers CD36-mediated ferroptosis and dysfunction of tumor infiltrating CD8+ T cells.
Cell death & disease.
2024 Feb; 15(2):145. doi:
10.1038/s41419-024-06503-1. [PMID: 38360744] - Zhangjie Wang, Yang Wang, Na Shen, Yu Liu, Xinyang Xu, Ruiqiu Zhu, Hao Jiang, Xiaoting Wu, Yunfei Wei, Jingyuan Tang. AMPKα1-mediated ZDHHC8 phosphorylation promotes the palmitoylation of SLC7A11 to facilitate ferroptosis resistance in glioblastoma.
Cancer letters.
2024 Jan; 584(?):216619. doi:
10.1016/j.canlet.2024.216619. [PMID: 38211651] - Shreya Banerjee, Rakesh Sarkar, Arpita Mukherjee, Suvrotoa Mitra, Animesh Gope, Mamta Chawla-Sarkar. Rotavirus-induced lncRNA SLC7A11-AS1 promotes ferroptosis by targeting cystine/glutamate antiporter xCT (SLC7A11) to facilitate virus infection.
Virus research.
2024 01; 339(?):199261. doi:
10.1016/j.virusres.2023.199261. [PMID: 37923170] - Yuhe Wang, Xu Han, Jingru Shi, Zeqi Liao, Yuanyue Zhang, Yuanyuan Li, Miao Jiang, Meijie Liu. Distinct Metabolites in Osteopenia and Osteoporosis: A Systematic Review and Meta-Analysis.
Nutrients.
2023 Nov; 15(23):. doi:
10.3390/nu15234895. [PMID: 38068753] - Yuki Kojima, Mamoru Tanaka, Makiko Sasaki, Keiji Ozeki, Takaya Shimura, Eiji Kubota, Hiromi Kataoka. Induction of ferroptosis by photodynamic therapy and enhancement of antitumor effect with ferroptosis inducers.
Journal of gastroenterology.
2023 Nov; ?(?):. doi:
10.1007/s00535-023-02054-y. [PMID: 37947872] - Hai-Hua Wang, Song-Qing Fan, Yu-Ting Zhan, Shu-Ping Peng, Wei-Yuan Wang. Suppression of the SLC7A11/glutathione axis causes ferroptosis and apoptosis and alters the mitogen-activated protein kinase pathway in nasopharyngeal carcinoma.
International journal of biological macromolecules.
2023 Nov; ?(?):127976. doi:
10.1016/j.ijbiomac.2023.127976. [PMID: 37951442] - Yueyang Liang, Lei Xia, Shuang Lu, Songru Yang, Shuting Guo, Xiaoli Shan, Pei Zhao, Chen Zhang, Wei Guo, Ming Xu, Huihua Chen, Rong Lu. A new mechanism of therapeutic effect of stachydrine on heart failure by inhibiting myocardial ferroptosis.
European journal of pharmacology.
2023 Sep; 954(?):175881. doi:
10.1016/j.ejphar.2023.175881. [PMID: 37385579] - Shuquan Lv, Huajun Li, Tianyu Zhang, Xiuhai Su, Wenjuan Sun, Qinghai Wang, Lixin Wang, Nana Feng, Shufang Zhang, Yuansong Wang, Huantian Cui. San-Huang-Yi-Shen capsule ameliorates diabetic nephropathy in mice through inhibiting ferroptosis.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Sep; 165(?):115086. doi:
10.1016/j.biopha.2023.115086. [PMID: 37418978] - Zuli Wang, Lianlian Ouyang, Na Liu, Tiansheng Li, Bokang Yan, Chao Mao, Desheng Xiao, Boyi Gan, Shuang Liu, Yongguang Tao. The DUBA-SLC7A11-c-Myc axis is critical for stemness and ferroptosis.
Oncogene.
2023 09; 42(36):2688-2700. doi:
10.1038/s41388-023-02744-0. [PMID: 37537342] - Miyeon Kim, Ju Young Bae, Soyeon Yoo, Hyun Woo Kim, Sang Ah Lee, Eui Tae Kim, Gwanpyo Koh. 2-Deoxy-d-ribose induces ferroptosis in renal tubular epithelial cells via ubiquitin-proteasome system-mediated xCT protein degradation.
Free radical biology & medicine.
2023 Sep; 208(?):384-393. doi:
10.1016/j.freeradbiomed.2023.08.027. [PMID: 37659699] - Junko Asakura, Manabu Nagao, Masakazu Shinohara, Makoto Nishimori, Sachiko Yoshikawa, Takuya Iino, Yutaro Seto, Hidekazu Tanaka, Seimi Satomi-Kobayashi, Tatsuro Ishida, Ken-Ichi Hirata, Ryuji Toh. Plasma cystine/methionine ratio is associated with left ventricular diastolic function in patients with heart disease.
Heart and vessels.
2023 Aug; ?(?):. doi:
10.1007/s00380-023-02302-4. [PMID: 37620665] - Weitang Guo, Xin Wang, Bing Lu, Jiaming Yu, Mingxian Xu, Renxuan Huang, Mingzhe Cheng, Meiling Yang, Wei Zhao, Changye Zou. Super-enhancer-driven MLX mediates redox balance maintenance via SLC7A11 in osteosarcoma.
Cell death & disease.
2023 07; 14(7):439. doi:
10.1038/s41419-023-05966-y. [PMID: 37460542] - Sapna Lonare, Monica Sharma, Vikram Dalal, Mrugendra Gubyad, Pranav Kumar, Deena Nath Gupta, Akshay Pareek, Shailly Tomar, Dilip Kumar Ghosh, Pravindra Kumar, Ashwani Kumar Sharma. Identification and evaluation of potential inhibitor molecules against TcyA from Candidatus Liberibacter asiaticus.
Journal of structural biology.
2023 Jun; 215(3):107992. doi:
10.1016/j.jsb.2023.107992. [PMID: 37394197] - Rafael Rosell, Anisha Jain, Jordi Codony-Servat, Eloisa Jantus-Lewintre, Blake Morrison, Jordi Barretina Ginesta, María González-Cao. Biological insights in non-small cell lung cancer.
Cancer biology & medicine.
2023 Jun; ?(?):. doi:
10.20892/j.issn.2095-3941.2023.0108. [PMID: 37381723] - Zhixin Ma, Wenle Ye, Jinghan Wang, Xin Huang, Jiansong Huang, Xia Li, Chao Hu, Chenying Li, Yile Zhou, Xiangjie Lin, Wenwen Wei, Yu Qian, Yutong Zhou, Shihui Mao, Xiufeng Yin, Bo Zhu, Jie Jin. Glutamate dehydrogenase 1: A novel metabolic target in inhibiting acute myeloid leukaemia progression.
British journal of haematology.
2023 May; ?(?):. doi:
10.1111/bjh.18884. [PMID: 37231991] - Feng He, Peng Zhang, Junlai Liu, Ruolei Wang, Randal J Kaufman, Benjamin C Yaden, Michael Karin. ATF4 suppresses hepatocarcinogenesis by inducing SLC7A11 (xCT) to block stress-related ferroptosis.
Journal of hepatology.
2023 Mar; ?(?):. doi:
10.1016/j.jhep.2023.03.016. [PMID: 36996941] - Xiaorui Wang, Lei Zhao, Chenxi Wang, Leichen Wang, Haisi Wu, Xuejiao Song, Wenjun Wang, Huae Xu, Xiaochen Dong. Potent nanoreactor-mediated ferroptosis-based strategy for the reversal of cancer chemoresistance to Sorafenib.
Acta biomaterialia.
2023 Feb; ?(?):. doi:
10.1016/j.actbio.2023.01.053. [PMID: 36736851] - Qing Tong, Wei Qin, Zheng-Hao Li, Chun Liu, Zi-Cheng Wang, Yuan Chu, Xun-Di Xu. SLC12A5 promotes hepatocellular carcinoma growth and ferroptosis resistance by inducing ER stress and cystine transport changes.
Cancer medicine.
2023 Jan; ?(?):. doi:
10.1002/cam4.5605. [PMID: 36645171] - Patrick Willems, Jingjing Huang, Joris Messens, Frank Van Breusegem. Functionally annotating cysteine disulfides and metal binding sites in the plant kingdom using AlphaFold2 predicted structures.
Free radical biology & medicine.
2023 01; 194(?):220-229. doi:
10.1016/j.freeradbiomed.2022.12.001. [PMID: 36493985] - Rehman Sarwar, Lei Li, Jiang Yu, Yijie Zhang, Rui Geng, Qingfeng Meng, Keming Zhu, Xiao-Li Tan. Functional Characterization of the Cystine-Rich-Receptor-like Kinases (CRKs) and Their Expression Response to Sclerotinia sclerotiorum and Abiotic Stresses in Brassica napus.
International journal of molecular sciences.
2022 Dec; 24(1):. doi:
10.3390/ijms24010511. [PMID: 36613954] - Amany Elshorbagy, Nasser E Bastani, Sindre Lee-Ødegård, Bente Øvrebø, Nadia Haj-Yasein, Karianne Svendsen, Cheryl Turner, Helga Refsum, Kathrine J Vinknes, Thomas Olsen. The association of fasting plasma thiol fractions with body fat compartments, biomarker profile, and adipose tissue gene expression.
Amino acids.
2022 Dec; ?(?):. doi:
10.1007/s00726-022-03229-2. [PMID: 36542145] - Minako Oda, Kousuke Fujibayashi, Minoru Wakasa, Shintaro Takano, Wataru Fujita, Michihiko Kitayama, Hiroaki Nakanishi, Kazuyuki Saito, Yasuyuki Kawai, Kouji Kajinami. Increased plasma glutamate in non-smokers with vasospastic angina pectoris is associated with plasma cystine and antioxidant capacity.
Scandinavian cardiovascular journal : SCJ.
2022 12; 56(1):180-186. doi:
10.1080/14017431.2022.2085884. [PMID: 35695518] - Nibin Shi, Xin Yan, Adeyemi S Adeleye, Xuxiang Zhang, Dongmei Zhou, Lijuan Zhao. Effects of WS2 Nanosheets on N2-fixing Cyanobacteria: ROS overproduction, cell membrane damage, and cell metabolic reprogramming.
The Science of the total environment.
2022 Nov; 849(?):157706. doi:
10.1016/j.scitotenv.2022.157706. [PMID: 35908696] - Yetong Feng, Jiayi Xu, Mengjiao Shi, Rongrong Liu, Lei Zhao, Xin Chen, Miaomiao Li, Yaping Zhao, Jiahui Chen, Wenjing Du, Pengfei Liu. COX7A1 enhances the sensitivity of human NSCLC cells to cystine deprivation-induced ferroptosis via regulating mitochondrial metabolism.
Cell death & disease.
2022 11; 13(11):988. doi:
10.1038/s41419-022-05430-3. [PMID: 36418320] - David A Armenta, Nouf N Laqtom, Grace Alchemy, Wentao Dong, Danielle Morrow, Carson D Poltorack, David A Nathanson, Monther Abu-Remalieh, Scott J Dixon. Ferroptosis inhibition by lysosome-dependent catabolism of extracellular protein.
Cell chemical biology.
2022 11; 29(11):1588-1600.e7. doi:
10.1016/j.chembiol.2022.10.006. [PMID: 36306785] - Takujiro Homma, Yuki Nishino, Junichi Fujii, Chikako Yokoyama. Flow cytometric determination of ferroptosis using a rat monoclonal antibody raised against ferroptotic cells.
Journal of immunological methods.
2022 11; 510(?):113358. doi:
10.1016/j.jim.2022.113358. [PMID: 36126779] - Mohammad K Okla, S Balasurya, Ibrahim A Alaraidh, Asmaa Mohebaldin, Abdullah A Al-Ghamdi, Mohammed A Al-Okla, Mostafa A Abdel-Maksoud, Ramadan F Abdelaziz, Walid Soufan, R Balakrishnaraja, Lija L Raju, Ajith M Thomas, S Sudheer Khan. Plasma-assisted in-situ preparation of L-cystine functionalized silver nanoparticle: An intelligent multicolor nano-sensing of cadmium and paracetamol from environmental sample.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2022 Oct; 279(?):121330. doi:
10.1016/j.saa.2022.121330. [PMID: 35605418] - Zihan Zhang, Rui Zheng, Caihua Zhu, Hongquan Geng, Guofeng Xu. Lipidomics characterization of the lipid metabolism profiles in a cystinuria rat model: Precalculus damage in the kidney of cystinuria.
Prostaglandins & other lipid mediators.
2022 10; 162(?):106651. doi:
10.1016/j.prostaglandins.2022.106651. [PMID: 35680078] - David Matye, Sumedha Gunewardena, Jianglei Chen, Huaiwen Wang, Yifeng Wang, Mohammad Nazmul Hasan, Lijie Gu, Yung Dai Clayton, Yanhong Du, Cheng Chen, Jacob E Friedman, Shelly C Lu, Wen-Xing Ding, Tiangang Li. TFEB regulates sulfur amino acid and coenzyme A metabolism to support hepatic metabolic adaptation and redox homeostasis.
Nature communications.
2022 09; 13(1):5696. doi:
10.1038/s41467-022-33465-9. [PMID: 36171419] - Chao-Yuan Huang, Li-Ju Chen, Grace Chen, Tzu-I Chao, Cheng-Yi Wang. SHP-1/STAT3-Signaling-Axis-Regulated Coupling between BECN1 and SLC7A11 Contributes to Sorafenib-Induced Ferroptosis in Hepatocellular Carcinoma.
International journal of molecular sciences.
2022 Sep; 23(19):. doi:
10.3390/ijms231911092. [PMID: 36232407] - Ling Gao, Qiang Gu, Hong Wang, Xingkong Ma, Feng Xue, Xing Zhang, Jiachun Ge, Tao Ding, Weijian Shen. [Determination of free amino acids in Eriocheir sinensis by ultra-high performance liquid chromatography-high resolution mass spectrometry].
Se pu = Chinese journal of chromatography.
2022 Sep; 40(9):825-832. doi:
10.3724/sp.j.1123.2022.03027. [PMID: 36156629] - Jennifer A Hollywood, Prasanna K Kallingappa, Pang Yuk Cheung, Renita M Martis, Sree Sreebhavan, Robert D 'Atiola, Aparajita Chatterjee, Emma J Buckels, Brya G Matthews, Paula M Lewis, Alan J Davidson. Cystinosin-deficient rats recapitulate the phenotype of nephropathic cystinosis.
American journal of physiology. Renal physiology.
2022 08; 323(2):F156-F170. doi:
10.1152/ajprenal.00277.2021. [PMID: 35695380] - Viola D'Ambrosio, Giovanna Capolongo, David Goldfarb, Giovanni Gambaro, Pietro Manuel Ferraro. Cystinuria: an update on pathophysiology, genetics, and clinical management.
Pediatric nephrology (Berlin, Germany).
2022 08; 37(8):1705-1711. doi:
10.1007/s00467-021-05342-y. [PMID: 34812923] - Yusei Tataka, Miki Haramura, Yuka Hamada, Miho Ono, Sakiko Toyoda, Toshiyuki Yamada, Ayano Hiratsu, Katsuhiko Suzuki, Masashi Miyashita. Effects of oral cystine and glutamine on exercise-induced changes in gastrointestinal permeability and damage markers in young men.
European journal of nutrition.
2022 Aug; 61(5):2331-2339. doi:
10.1007/s00394-022-02806-1. [PMID: 35106632] - Hui Chen, Lixing Cao, Kai Han, Han Zhang, Jinling Cui, Xuan Ma, Shuang Zhao, Chong Zhao, Shutao Yin, Lihong Fan, Hongbo Hu. Patulin disrupts SLC7A11-cystine-cysteine-GSH antioxidant system and promotes renal cell ferroptosis both in vitro and in vivo.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.
2022 Aug; 166(?):113255. doi:
10.1016/j.fct.2022.113255. [PMID: 35772596] - Shuichi Okamoto, Shogo Tamura, Naomi Sanda, Koya Odaira, Yuri Hayakawa, Masato Mukaide, Atsuo Suzuki, Takeshi Kanematsu, Fumihiko Hayakawa, Akira Katsumi, Hitoshi Kiyoi, Tetsuhito Kojima, Tadashi Matsushita, Nobuaki Suzuki. VWF-Gly2752Ser, a novel non-cysteine substitution variant in the CK domain, exhibits severe secretory impairment by hampering C-terminal dimer formation.
Journal of thrombosis and haemostasis : JTH.
2022 08; 20(8):1784-1796. doi:
10.1111/jth.15746. [PMID: 35491445] - Patrick Krohn, Laura Rita Rega, Marianne Harvent, Beatrice Paola Festa, Anna Taranta, Alessandro Luciani, Joseph Dewulf, Alessio Cremonesi, Francesca Diomedi Camassei, James V M Hanson, Christina Gerth-Kahlert, Francesco Emma, Marine Berquez, Olivier Devuyst. Multisystem involvement, defective lysosomes and impaired autophagy in a novel rat model of nephropathic cystinosis.
Human molecular genetics.
2022 Jul; 31(13):2262-2278. doi:
10.1093/hmg/ddac033. [PMID: 35137071] - Guangming He, Keling Chen, Hao Wang, Xiaoou Li, Wenhao Li, Lian Liu, Jun Chen, Deqing Yang, Jun Hu, Dan Xu, Fuqiang Wen, Tao Wang. Fudosteine attenuates acute lung injury in septic mice by inhibiting pyroptosis via the TXNIP/NLRP3/GSDMD pathway.
European journal of pharmacology.
2022 Jul; 926(?):175047. doi:
10.1016/j.ejphar.2022.175047. [PMID: 35609679] - Leslie Magtanong, Grace D Mueller, Kevin J Williams, Maximilian Billmann, Katherine Chan, David A Armenta, Jason Moffat, Charles Boone, Chad L Myers, James A Olzmann, Steven J Bensinger, Scott J Dixon. Context-dependent regulation of ferroptosis sensitivity.
Cell chemical biology.
2022 Jun; ?(?):. doi:
10.1016/j.chembiol.2022.06.004. [PMID: 35809566] - Fatima Ezzahra El Oumari, Dalila Bousta, Hamada Imtara, Anissa Lahrichi, Radouane Elhabbani, Ghita El Mouhri, Omkulthom Al Kamaly, Asmaa Saleh, Mohammad Khalid Parvez, Andriy Grafov, Tarik Sqalli Houssaini. Chemical Composition and Anti-Urolithiatic Activity of Extracts from Argania spinosa (L.) Skeels Press-Cake and Acacia senegal (L.) Willd.
Molecules (Basel, Switzerland).
2022 Jun; 27(13):. doi:
10.3390/molecules27133973. [PMID: 35807240] - Eiji Sasaki, Hiroyuki Yamamoto, Toru Asari, Rira Matsuta, Seiya Ota, Yuka Kimura, Shizuka Sasaki, Kyota Ishibashi, Yuji Yamamoto, Kenjiro Kami, Masataka Ando, Eiichi Tsuda, Yasuyuki Ishibashi. Metabolomics with severity of radiographic knee osteoarthritis and early phase synovitis in middle-aged women from the Iwaki Health Promotion Project: a cross-sectional study.
Arthritis research & therapy.
2022 06; 24(1):145. doi:
10.1186/s13075-022-02830-w. [PMID: 35710532] - Francesco Emma, Giovanni Montini, Marco Pennesi, Licia Peruzzi, Enrico Verrina, Bianca Maria Goffredo, Fabrizio Canalini, David Cassiman, Silvia Rossi, Elena Levtchenko. Biomarkers in Nephropathic Cystinosis: Current and Future Perspectives.
Cells.
2022 06; 11(11):. doi:
10.3390/cells11111839. [PMID: 35681534] - Zihan Zhang, Rui Zheng, Zhoutong Chen, Xia Zhan, Xiaoliang Fang, Meizhen Liu, Yongmei Li, Yonghu Xu, Dali Li, Hongquan Geng, Xiaohui Zhang, Guofeng Xu. Differences in renal cortex transcriptional profiling of wild-type and novel type B cystinuria model rats.
Urolithiasis.
2022 Jun; 50(3):279-291. doi:
10.1007/s00240-022-01321-6. [PMID: 35416493] - Anita Csorba, Erika Maka, Attila Szabó, Kata Kelen, György Reusz, Zoltán Zsolt Nagy. Ocular treatment of cystinosis with eye drop containing cysteamine.
Orvosi hetilap.
2022 May; 163(21):846-852. doi:
10.1556/650.2022.32484. [PMID: 35598215] - Yongchan Lee, Pattama Wiriyasermkul, Pornparn Kongpracha, Satomi Moriyama, Deryck J Mills, Werner Kühlbrandt, Shushi Nagamori. Ca2+-mediated higher-order assembly of heterodimers in amino acid transport system b0,+ biogenesis and cystinuria.
Nature communications.
2022 05; 13(1):2708. doi:
10.1038/s41467-022-30293-9. [PMID: 35577790] - Takujiro Homma, Sho Kobayashi, Junichi Fujii. Methionine Deprivation Reveals the Pivotal Roles of Cell Cycle Progression in Ferroptosis That Is Induced by Cysteine Starvation.
Cells.
2022 05; 11(10):. doi:
10.3390/cells11101603. [PMID: 35626640] - Latifa Chkioua, Yessine Amri, Chaima Saheli, Wassila Mili, Sameh Mabrouk, Imen Chabchoub, Hela Boudabous, Wissem Ben Azzouz, Hadhami Ben Turkia, Salima Ferchichi, Neji Tebib, Taieb Massoud, Mohamed Ghorbel, Sandrine Laradi. Molecular characterization of CTNS mutations in Tunisian patients with ocular cystinosis.
Diagnostic pathology.
2022 May; 17(1):44. doi:
10.1186/s13000-022-01221-8. [PMID: 35524314] - Choi Yi Li, Fabian B H Rehm, Kuok Yap, Christina N Zdenek, Maxim D Harding, Bryan G Fry, Thomas Durek, David J Craik, Simon J de Veer. Cystine Knot Peptides with Tuneable Activity and Mechanism.
Angewandte Chemie (International ed. in English).
2022 05; 61(19):e202200951. doi:
10.1002/anie.202200951. [PMID: 35224831] - Shigo Ikeyama, Shoichiro Kanda, Shinichi Sakamoto, Akiko Sakoda, Kenichiro Miura, Ryu Yoneda, Ayumi Nogi, Shohei Ariji, Mai Shimoda, Mayumi Ono, Sachiko Kanda, Seiichiro Yokoyama, Kan Takahashi, Yoshiki Yokoyama, Motoshi Hattori. A case of early onset cystinuria in a 4-month-old girl.
CEN case reports.
2022 05; 11(2):216-219. doi:
10.1007/s13730-021-00655-1. [PMID: 34669168] - Ronald A Hill, Yong-Yu Liu. N6 -methyladenosine-RNA methylation promotes expression of solute carrier family 7 member 11, an uptake transporter of cystine for lipid reactive oxygen species scavenger glutathione synthesis, leading to hepatoblastoma ferroptosis resistance.
Clinical and translational medicine.
2022 05; 12(5):e889. doi:
10.1002/ctm2.889. [PMID: 35604883] - Victor Ruiz-Rodado, Tyrone Dowdy, Adrian Lita, Tamalee Kramp, Meili Zhang, Jinkyu Jung, Ana Dios-Esponera, Lumin Zhang, Christel C Herold-Mende, Kevin Camphausen, Mark R Gilbert, Mioara Larion. Cysteine is a limiting factor for glioma proliferation and survival.
Molecular oncology.
2022 05; 16(9):1777-1794. doi:
10.1002/1878-0261.13148. [PMID: 34856072] - Olga V Morozova, Valentin A Manuvera, Alexander E Grishchechkin, Nikolay A Barinov, Nataliya V Shevlyagina, Vladimir G Zhukhovitsky, Vassili N Lazarev, Dmitry V Klinov. Targeting of Silver Cations, Silver-Cystine Complexes, Ag Nanoclusters, and Nanoparticles towards SARS-CoV-2 RNA and Recombinant Virion Proteins.
Viruses.
2022 04; 14(5):. doi:
10.3390/v14050902. [PMID: 35632644] - Koenraad Veys, Sante Princiero Berlingerio, Dries David, Tjessa Bondue, Katharina Held, Ahmed Reda, Martijn van den Broek, Koen Theunis, Mirian Janssen, Elisabeth Cornelissen, Joris Vriens, Francesca Diomedi-Camassei, Rik Gijsbers, Lambertus van den Heuvel, Fanny O Arcolino, Elena Levtchenko. Urine-Derived Kidney Progenitor Cells in Cystinosis.
Cells.
2022 04; 11(7):. doi:
10.3390/cells11071245. [PMID: 35406807] - Doris Breu, Elisabeth Müller. [Feline uroliths: Analysis of frequency and epidemiology in Germany (2016-2020)].
Tierarztliche Praxis. Ausgabe K, Kleintiere/Heimtiere.
2022 Apr; 50(2):102-111. doi:
10.1055/a-1795-8078. [PMID: 35523164] - Lise Verbruggen, Gamze Ates, Olaya Lara, Jolien De Munck, Agnès Villers, Laura De Pauw, Sigrid Ottestad-Hansen, Sho Kobayashi, Pauline Beckers, Pauline Janssen, Hideyo Sato, Yun Zhou, Emmanuel Hermans, Rose Njemini, Lutgarde Arckens, Niels C Danbolt, Dimitri De Bundel, Joeri L Aerts, Kurt Barbé, Benoit Guillaume, Laurence Ris, Eduard Bentea, Ann Massie. Lifespan extension with preservation of hippocampal function in aged system xc--deficient male mice.
Molecular psychiatry.
2022 Apr; 27(4):2355-2368. doi:
10.1038/s41380-022-01470-5. [PMID: 35181756] - Acharya Balkrishna, Vivek Gohel, Priya Kumari, Moumita Manik, Kunal Bhattacharya, Rishabh Dev, Anurag Varshney. Livogrit Prevents Methionine-Cystine Deficiency Induced Nonalcoholic Steatohepatitis by Modulation of Steatosis and Oxidative Stress in Human Hepatocyte-Derived Spheroid and in Primary Rat Hepatocytes.
Bioengineered.
2022 04; 13(4):10811-10826. doi:
10.1080/21655979.2022.2065789. [PMID: 35485140] - Pingzhao Zhang, Kun Gao, Liang Zhang, Huiru Sun, Xiaying Zhao, Yajuan Liu, Zeheng Lv, Qing Shi, Yingji Chen, Dongyue Jiao, Yao Li, Wei Gu, Chenji Wang. CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14ARF degradation.
Cell death and differentiation.
2022 04; 29(4):758-771. doi:
10.1038/s41418-021-00890-0. [PMID: 34743205] - Sebastien Kissling, Olivier Bonny. Concomitant Urinary Triple Phosphate and Cystine Crystals.
The New England journal of medicine.
2022 Mar; 386(12):1165. doi:
10.1056/nejmicm2114197. [PMID: 35320646] - Jun Uchiyama, Masahiro Akiyama, Koji Hase, Yoshito Kumagai, Yun-Gi Kim. Gut microbiota reinforce host antioxidant capacity via the generation of reactive sulfur species.
Cell reports.
2022 03; 38(10):110479. doi:
10.1016/j.celrep.2022.110479. [PMID: 35263581] - Paritosh Pande, Erin P Madeen, David E Williams, Susan R Crowell, Ted J Ognibene, Ken W Turteltaub, Richard A Corley, Jordan N Smith. Translating dosimetry of Dibenzo[def,p]chrysene (DBC) and metabolites across dose and species using physiologically based pharmacokinetic (PBPK) modeling.
Toxicology and applied pharmacology.
2022 03; 438(?):115830. doi:
10.1016/j.taap.2021.115830. [PMID: 34933053] - Kazuki Hayashima, Hironori Katoh. Expression of gamma-glutamyltransferase 1 in glioblastoma cells confers resistance to cystine deprivation-induced ferroptosis.
The Journal of biological chemistry.
2022 03; 298(3):101703. doi:
10.1016/j.jbc.2022.101703. [PMID: 35148992] - Alexander G Shtukenberg, Longqin Hu, Amrik Sahota, Bart Kahr, Michael D Ward. Disrupting Crystal Growth through Molecular Recognition: Designer Therapies for Kidney Stone Prevention.
Accounts of chemical research.
2022 02; 55(4):516-525. doi:
10.1021/acs.accounts.1c00631. [PMID: 35088591] - Elena Sendino Garví, Rosalinde Masereeuw, Manoe J Janssen. Bioengineered Cystinotic Kidney Tubules Recapitulate a Nephropathic Phenotype.
Cells.
2022 01; 11(1):. doi:
10.3390/cells11010177. [PMID: 35011739] - Zhenyuan Ma, Yibao Wei, Li Zhang, Xiaoqing Shi, Runlin Xing, Taiyang Liao, Nan Yang, Xiaochen Li, Lishi Jie, Peimin Wang. GCTOF-MS Combined LC-QTRAP-MS/MS Reveals Metabolic Difference Between Osteoarthritis and Osteoporotic Osteoarthritis and the Intervention Effect of Erxian Decoction.
Frontiers in endocrinology.
2022; 13(?):905507. doi:
10.3389/fendo.2022.905507. [PMID: 35966099] - Zhentian Ni, Xiaoli Nie, Hairong Zhang, Lingquan Wang, Zixiang Geng, Xiling Du, Haiyang Qian, Wentao Liu, Te Liu. Atranorin driven by nano materials SPION lead to ferroptosis of gastric cancer stem cells by weakening the mRNA 5-hydroxymethylcytidine modification of the Xc-/GPX4 axis and its expression.
International journal of medical sciences.
2022; 19(11):1680-1694. doi:
10.7150/ijms.73701. [PMID: 36237989] - Camille Rauturier, Christelle Machon, Delphine Demède, Laurence Dubourg, Justine Bacchetta, Aurélia Bertholet-Thomas. Composition of urinary stones in children: clinical and metabolic determinants in a French tertiary care center.
European journal of pediatrics.
2021 Dec; 180(12):3555-3563. doi:
10.1007/s00431-021-04151-7. [PMID: 34165592] - Anna Taranta, Mohamed A Elmonem, Francesco Bellomo, Ester De Leo, Sara Boenzi, Manoe J Janssen, Amer Jamalpoor, Sara Cairoli, Anna Pastore, Cristiano De Stefanis, Manuela Colucci, Laura R Rega, Isabella Giovannoni, Paola Francalanci, Lambertus P van den Heuvel, Carlo Dionisi-Vici, Bianca M Goffredo, Rosalinde Masereeuw, Elena Levtchenko, Francesco Emma. Benefits and Toxicity of Disulfiram in Preclinical Models of Nephropathic Cystinosis.
Cells.
2021 11; 10(12):. doi:
10.3390/cells10123294. [PMID: 34943802] - Francesco Emma, William Van't Hoff, Katharina Hohenfellner, Rezan Topaloglu, Marcella Greco, Gema Ariceta, Chiara Bettini, Detlef Bockenhauer, Koenraad Veys, Lars Pape, Sally Hulton, Suzanne Collin, Fatih Ozaltin, Aude Servais, Georges Deschênes, Robert Novo, Aurélia Bertholet-Thomas, Jun Oh, Elisabeth Cornelissen, Mirian Janssen, Dieter Haffner, Lucilla Ravà, Corinne Antignac, Olivier Devuyst, Patrick Niaudet, Elena Levtchenko. An international cohort study spanning five decades assessed outcomes of nephropathic cystinosis.
Kidney international.
2021 11; 100(5):1112-1123. doi:
10.1016/j.kint.2021.06.019. [PMID: 34237326] - Hagar Elkafrawy, Radwa Mehanna, Fayrouz Ali, Ayman Barghash, Iman Dessouky, Fredrik Jernerén, Cheryl Turner, Helga Refsum, Amany Elshorbagy. Extracellular cystine influences human preadipocyte differentiation and correlates with fat mass in healthy adults.
Amino acids.
2021 Oct; 53(10):1623-1634. doi:
10.1007/s00726-021-03071-y. [PMID: 34519922] - Hao Yang, Haoyang Zheng, Yue Pan, Weiguo Zhang, Mengjing Yang, Huiling Du, Anan Yu, Ping Li, Xiaoyan Chen, Wei Xie, Kaiming Ren, Ying Zhao, Tianjiao Wang, Xiaoyan He, Zhaoli Zhou. Quantitative proteomic analysis of the effects of dietary deprivation of methionine and cystine on A549 xenograft and A549 xenograft-bearing mouse.
Proteomics.
2021 10; 21(20):e2100007. doi:
10.1002/pmic.202100007. [PMID: 34482643] - Ståle Ellingsen, Shailesh Narawane, Anders Fjose, Tiziano Verri, Ivar Rønnestad. The zebrafish cationic amino acid transporter/glycoprotein-associated family: sequence and spatiotemporal distribution during development of the transport system b0,+ (slc3a1/slc7a9).
Fish physiology and biochemistry.
2021 Oct; 47(5):1507-1525. doi:
10.1007/s10695-021-00984-z. [PMID: 34338990] - David Allaway, Matthew Harrison, Richard Haydock, Phillip Watson. Adaptations Supporting Plasma Methionine on a Limited-Methionine, High-Cystine Diet Alter the Canine Plasma Metabolome Consistent with Interventions that Extend Life Span in Other Species.
The Journal of nutrition.
2021 10; 151(10):3125-3136. doi:
10.1093/jn/nxab204. [PMID: 34224573] - Moharram Habibnejad-Korayem, Omid Nabiei, Sima Gharibshah, Rouzbeh Nouhi-Hefzabad. Atomistic Assessment of Cystine Kidney Stone Behavior in a Mechanical Breakdown Process by Nanobiorobots through Classical Molecular Dynamics Simulations.
The journal of physical chemistry. B.
2021 09; 125(36):10344-10354. doi:
10.1021/acs.jpcb.1c04682. [PMID: 34463504] - Christina van Stein, Sabrina Klank, Marianne Grüneberg, Chris Ottolenghi, Jürgen Grebe, Janine Reunert, Erik Harms, Thorsten Marquardt. A comparison of immediate release and delayed release cysteamine in 17 patients with nephropathic cystinosis.
Orphanet journal of rare diseases.
2021 09; 16(1):387. doi:
10.1186/s13023-021-01991-2. [PMID: 34521447] - Yanchun Li, Xin Wang, Zhihui Huang, Yi Zhou, Jun Xia, Wanye Hu, Xu Wang, Jing Du, Xiangmin Tong, Ying Wang. CISD3 inhibition drives cystine-deprivation induced ferroptosis.
Cell death & disease.
2021 09; 12(9):839. doi:
10.1038/s41419-021-04128-2. [PMID: 34497268] - Tadashi Kimura. Stability and Safety of Inhibitor Cystine Knot Peptide, GTx1-15, from the Tarantula Spider Grammostola rosea.
Toxins.
2021 09; 13(9):. doi:
10.3390/toxins13090621. [PMID: 34564625] - Sante Princiero Berlingerio, Junling He, Lies De Groef, Harold Taeter, Tomas Norton, Pieter Baatsen, Sara Cairoli, Bianca Goffredo, Peter de Witte, Lambertus van den Heuvel, Hans J Baelde, Elena Levtchenko. Renal and Extra Renal Manifestations in Adult Zebrafish Model of Cystinosis.
International journal of molecular sciences.
2021 Aug; 22(17):. doi:
10.3390/ijms22179398. [PMID: 34502306] - Daniel M Kremer, Barbara S Nelson, Lin Lin, Emily L Yarosz, Christopher J Halbrook, Samuel A Kerk, Peter Sajjakulnukit, Amy Myers, Galloway Thurston, Sean W Hou, Eileen S Carpenter, Anthony C Andren, Zeribe C Nwosu, Nicholas Cusmano, Stephanie Wisner, Nneka E Mbah, Mengrou Shan, Nupur K Das, Brian Magnuson, Andrew C Little, Milan R Savani, Johanna Ramos, Tina Gao, Stephen A Sastra, Carmine F Palermo, Michael A Badgley, Li Zhang, John M Asara, Samuel K McBrayer, Marina Pasca di Magliano, Howard C Crawford, Yatrik M Shah, Kenneth P Olive, Costas A Lyssiotis. GOT1 inhibition promotes pancreatic cancer cell death by ferroptosis.
Nature communications.
2021 08; 12(1):4860. doi:
10.1038/s41467-021-24859-2. [PMID: 34381026] - Pranavi Koppula, Li Zhuang, Boyi Gan. Cystine transporter SLC7A11/xCT in cancer: ferroptosis, nutrient dependency, and cancer therapy.
Protein & cell.
2021 08; 12(8):599-620. doi:
10.1007/s13238-020-00789-5. [PMID: 33000412] - Rezan Topaloglu. Nephropathic cystinosis: an update on genetic conditioning.
Pediatric nephrology (Berlin, Germany).
2021 06; 36(6):1347-1352. doi:
10.1007/s00467-020-04638-9. [PMID: 32564281] - Caroline Prot-Bertoye, Michel Daudon, Isabelle Tostivint, Marie-Paule Dousseaux, Jérôme Defazio, Olivier Traxer, Bertrand Knebelmann, Marie Courbebaisse. [Cystinuria].
Nephrologie & therapeutique.
2021 Apr; 17S(?):S100-S107. doi:
10.1016/j.nephro.2020.03.001. [PMID: 33910689] - Nishanth Kuganesan, Samkeliso Dlamini, Jade McDaniel, Viranga L M Tillekeratne, William R Taylor. Identification and initial characterization of a potent inhibitor of ferroptosis.
Journal of cellular biochemistry.
2021 04; 122(3-4):413-424. doi:
10.1002/jcb.29870. [PMID: 33377232] - Damian Neubauer, Maciej Jaśkiewicz, Marta Bauer, Agata Olejniczak-Kęder, Emilia Sikorska, Karol Sikora, Wojciech Kamysz. Biological and Physico-Chemical Characteristics of Arginine-Rich Peptide Gemini Surfactants with Lysine and Cystine Spacers.
International journal of molecular sciences.
2021 Mar; 22(7):. doi:
10.3390/ijms22073299. [PMID: 33804887] - Zhixuan Zhao, Shuai Li, Chen Ji, Yong Zhou, Changsheng Li, Wenqin Wang. Genetic Variation of the Serine Acetyltransferase Gene Family for Sulfur Assimilation in Maize.
Genes.
2021 03; 12(3):. doi:
10.3390/genes12030437. [PMID: 33808582] - Yilei Zhang, Robert V Swanda, Litong Nie, Xiaoguang Liu, Chao Wang, Hyemin Lee, Guang Lei, Chao Mao, Pranavi Koppula, Weijie Cheng, Jie Zhang, Zhenna Xiao, Li Zhuang, Bingliang Fang, Junjie Chen, Shu-Bing Qian, Boyi Gan. mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation.
Nature communications.
2021 03; 12(1):1589. doi:
10.1038/s41467-021-21841-w. [PMID: 33707434] - Sunil Daga, Victor Palit, James A Forster, Chandra Shekhar Biyani, Adrian D Joyce, Antonia Borissova Dimitrova. An Update on Evaluation and Management in Cystinuria.
Urology.
2021 03; 149(?):70-75. doi:
10.1016/j.urology.2020.12.025. [PMID: 33421442] - Liang-Jen Wang, Liang-Chun Lin, Sheng-Yu Lee, Chih-Ching Wu, Wen-Jiun Chou, Chia-Fen Hsu, Huai-Hsuan Tseng, Wei-Che Lin. l-Cystine is associated with the dysconnectivity of the default-mode network and salience network in attention-deficit/hyperactivity disorder.
Psychoneuroendocrinology.
2021 03; 125(?):105105. doi:
10.1016/j.psyneuen.2020.105105. [PMID: 33338922] - Tien T Dang, Lai Y Chan, Benjamin J Tombling, Peta J Harvey, Edward K Gilding, David J Craik. In Planta Discovery and Chemical Synthesis of Bracelet Cystine Knot Peptides from Rinorea bengalensis.
Journal of natural products.
2021 02; 84(2):395-407. doi:
10.1021/acs.jnatprod.0c01065. [PMID: 33570395] - Roswitha Siener, Norman Bitterlich, Hubert Birwé, Albrecht Hesse. The Impact of Diet on Urinary Risk Factors for Cystine Stone Formation.
Nutrients.
2021 Feb; 13(2):. doi:
10.3390/nu13020528. [PMID: 33561968] - Kazuki Hayashima, Ikuo Kimura, Hironori Katoh. Role of ferritinophagy in cystine deprivation-induced cell death in glioblastoma cells.
Biochemical and biophysical research communications.
2021 02; 539(?):56-63. doi:
10.1016/j.bbrc.2020.12.075. [PMID: 33421769] - Aude Servais, Kay Thomas, Luca Dello Strologo, John A Sayer, Soumeya Bekri, Aurelia Bertholet-Thomas, Matthew Bultitude, Giovanna Capolongo, Rimante Cerkauskiene, Michel Daudon, Steeve Doizi, Valentine Gillion, Silvia Gràcia-Garcia, Jan Halbritter, Laurence Heidet, Marleen van den Heijkant, Sandrine Lemoine, Bertrand Knebelmann, Francesco Emma, Elena Levtchenko. Cystinuria: clinical practice recommendation.
Kidney international.
2021 01; 99(1):48-58. doi:
10.1016/j.kint.2020.06.035. [PMID: 32918941] - Peng-Cheng Zhu, Yong-Xiang Chen. Facile Synthesis of Boc-Protected Selenocystine and its Compatibility with Late-Stage Farnesylation at Cysteine Site.
Protein and peptide letters.
2021; 28(6):603-611. doi:
10.2174/0929866527666201223094249. [PMID: 33357178] - Saroj Kumar, Amresh Gupta, Chanchal Kumar Mishra, Satyawan Singh. Novel Aceclofenac-l-Cystine and Aceclofenac-Urea Cocrystals with Enhanced Oral Bioavailability.
Current drug delivery.
2021; 18(8):1174-1181. doi:
10.2174/1567201818666210218103303. [PMID: 33602085] - Yunjin Bai, Yin Tang, Jiahao Wang, Xiaoming Wang, Zhenghao Wang, Dehong Cao, Ping Han, Jia Wang. Tolvaptan treatment of cystine urolithiasis in a mouse model of cystinuria.
World journal of urology.
2021 Jan; 39(1):263-269. doi:
10.1007/s00345-020-03166-3. [PMID: 32189089] - Marya Bengali, Spencer Goodman, Xiaoying Sun, Magdalene A Dohil, Ranjan Dohil, Robert Newbury, Tatiana Lobry, Laura Hernandez, Corinne Antignac, Sonia Jain, Stephanie Cherqui. Non-invasive intradermal imaging of cystine crystals in cystinosis.
PloS one.
2021; 16(3):e0247846. doi:
10.1371/journal.pone.0247846. [PMID: 33661986] - Inês Vieira da Silva, Bárbara P Soares, Catarina Pimpão, Rui M A Pinto, Teresa Costa, João P B Freire, Etienne Corrent, Tristan Chalvon-Demersay, José A M Prates, Paula A Lopes, Graça Soveral. Glutamine and cystine-enriched diets modulate aquaporins gene expression in the small intestine of piglets.
PloS one.
2021; 16(1):e0245739. doi:
10.1371/journal.pone.0245739. [PMID: 33465153] - Mariluz Soula, Ross A Weber, Omkar Zilka, Hanan Alwaseem, Konnor La, Frederick Yen, Henrik Molina, Javier Garcia-Bermudez, Derek A Pratt, Kıvanç Birsoy. Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers.
Nature chemical biology.
2020 12; 16(12):1351-1360. doi:
10.1038/s41589-020-0613-y. [PMID: 32778843]