Fluconazole (BioDeep_00000001470)

 

Secondary id: BioDeep_00000397734

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


2,4-Difluoro-alpha,alpha-bis(1H-1,2,4-triazol-1-ylmethyl)benzyl alcohol

化学式: C13H12F2N6O (306.1041)
中文名称: 氟康唑
谱图信息: 最多检出来源 Homo sapiens(blood) 19.32%

分子结构信息

SMILES: C1=CC(=C(C=C1F)F)C(CN2C=NC=N2)(CN3C=NC=N3)O
InChI: InChI=1S/C13H12F2N6O/c14-10-1-2-11(12(15)3-10)13(22,4-20-8-16-6-18-20)5-21-9-17-7-19-21/h1-3,6-9,22H,4-5H2

描述信息

Fluconazole is only found in individuals that have used or taken this drug. It is a triazole antifungal agent that is used to treat oropharyngeal candidiasis and cryptococcal meningitis in AIDS. [PubChem]Fluconazole interacts with 14-α demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Fluconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.
J - Antiinfectives for systemic use > J02 - Antimycotics for systemic use > J02A - Antimycotics for systemic use > J02AC - Triazole and tetrazole derivatives
D - Dermatologicals > D01 - Antifungals for dermatological use > D01A - Antifungals for topical use > D01AC - Imidazole and triazole derivatives
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D065088 - Steroid Synthesis Inhibitors
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065689 - Cytochrome P-450 CYP2C19 Inhibitors
D004791 - Enzyme Inhibitors > D065607 - Cytochrome P-450 Enzyme Inhibitors > D065688 - Cytochrome P-450 CYP2C9 Inhibitors
D004791 - Enzyme Inhibitors > D065088 - Steroid Synthesis Inhibitors > D058888 - 14-alpha Demethylase Inhibitors
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
D000890 - Anti-Infective Agents > D000935 - Antifungal Agents
C254 - Anti-Infective Agent > C514 - Antifungal Agent
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

57 个代谢物同义名

2,4-Difluoro-alpha,alpha-bis(1H-1,2,4-triazol-1-ylmethyl)benzyl alcohol; 2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol; 2-(2,4-DIFLUOROPHENYL)-1,3-di(1H-1,2,4-triazol-1-yl)propan-2-ol; 2,4-Difluoro-α,α-bis(1H-1,2,4-triazol-1-ylmethyl)benzyl alcohol; 2,4-Difluoro-a,a-bis(1H-1,2,4-triazol-1-ylmethyl)benzyl alcohol; CT Arzneimittel brand OF fluconazole; CT-Arzneimittel brand OF fluconazole; Lichtenstein brand OF fluconazole; Ratiopharm brand OF fluconazole; Betapharm brand OF fluconazole; Armstrong brand OF fluconazole; Alpharma brand OF fluconazole; Pfleger brand OF fluconazole; Silanes brand OF fluconazole; Chemia brand OF fluconazole; Apotex brand OF fluconazole; Pfizer brand OF fluconazole; Effik brand OF fluconazole; Stada brand OF fluconazole; Aliud brand OF fluconazole; Hexal brand OF fluconazole; Lesvi brand OF fluconazole; Vita brand OF fluconazole; Mack brand OF fluconazole; SAT brand OF fluconazole; AbZ brand OF fluconazole; Fluconazol ratiopharm; Fluconazol-ratiopharm; Fluconazole capsules; Fluconazol von CT; Fluconazol stada; Fluconazol-isis; Apo fluconazole; Apo-fluconazole; Fluconazol isis; Fluconazol abz; Fluconazol al; Fluconazolum; fluconazole; Neofomiral; Fluconazol; Fluc hexal; Oxifungol; Flucobeta; Triflucan; FlucoLich; Diflucan; Flunazul; Solacap; Béagyne; Biozole; Fungata; Lavisa; Elazor; Loitin; Zonal; Fluconazole



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 5 ALB, CAT, CYP2C19, CYP2C9, CYP3A4
Endoplasmic reticulum membrane 7 CD4, CYP2C19, CYP2C9, CYP3A4, HMGCR, HSP90B1, MSMO1
Nucleus 2 ALB, HSP90B1
cytosol 4 ALB, CAT, GPT, HSP90B1
centrosome 1 ALB
Cell membrane 2 CD4, TNF
Multi-pass membrane protein 3 ATP4A, HMGCR, MSMO1
Synapse 1 TAC1
cell surface 1 TNF
Golgi apparatus 1 ALB
Golgi membrane 1 INS
neuronal cell body 2 TAC1, TNF
smooth endoplasmic reticulum 1 HSP90B1
plasma membrane 8 ATP4A, CD4, CSF2, CYP2C19, CYP2C9, IFNLR1, MSMO1, TNF
Membrane 7 ATP4A, CAT, CYP3A4, HMGCR, HSP90B1, IFNLR1, MSMO1
apical plasma membrane 1 ATP4A
axon 1 TAC1
extracellular exosome 4 ALB, CAT, GPT, HSP90B1
endoplasmic reticulum 4 ALB, HMGCR, HSP90B1, MSMO1
extracellular space 10 ALB, ATP4A, CRP, CSF2, CSF3, IFNG, IL10, INS, TAC1, TNF
lysosomal lumen 1 CSF3
perinuclear region of cytoplasm 1 HSP90B1
mitochondrion 1 CAT
protein-containing complex 3 ALB, CAT, HSP90B1
intracellular membrane-bounded organelle 5 CAT, CSF2, CYP2C19, CYP2C9, CYP3A4
Microsome membrane 2 CYP2C9, CYP3A4
Single-pass type I membrane protein 2 CD4, IFNLR1
Secreted 7 ALB, CRP, CSF2, CSF3, IFNG, IL10, INS
extracellular region 11 ALB, CAT, CRP, CSF2, CSF3, HSP90B1, IFNG, IL10, INS, TAC1, TNF
mitochondrial matrix 1 CAT
anchoring junction 1 ALB
external side of plasma membrane 2 CD4, TNF
midbody 1 HSP90B1
Early endosome 1 CD4
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Apical cell membrane 1 ATP4A
Membrane raft 2 CD4, TNF
focal adhesion 2 CAT, HSP90B1
Peroxisome 1 CAT
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 2 CAT, HMGCR
collagen-containing extracellular matrix 1 HSP90B1
ciliary basal body 1 ALB
phagocytic cup 1 TNF
centriole 1 ALB
spindle pole 1 ALB
blood microparticle 1 ALB
endosome lumen 1 INS
Melanosome 1 HSP90B1
sperm plasma membrane 1 HSP90B1
Peroxisome membrane 1 HMGCR
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 2 CAT, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 4 ALB, CD4, HSP90B1, INS
platelet alpha granule lumen 1 ALB
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
clathrin-coated endocytic vesicle membrane 1 CD4
Sarcoplasmic reticulum lumen 1 HSP90B1
granulocyte macrophage colony-stimulating factor receptor complex 1 CSF2
endocytic vesicle lumen 2 CSF3, HSP90B1
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 1 CD4
catalase complex 1 CAT
endoplasmic reticulum chaperone complex 1 HSP90B1
potassium:proton exchanging ATPase complex 1 ATP4A
ciliary transition fiber 1 ALB
interleukin-28 receptor complex 1 IFNLR1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Yasmim Isabel Retore, Fabíola Lucini, Rafael Cardoso Rial, Claudia Andrea Lima Cardoso, Pedro Filho Noronha Souza, Simone Simionatto, Luana Rossato. Antifungal activity of Caryocar brasiliense camb. Alone or along with antifungal agents against multidrug-resistant Candida auris. Journal of ethnopharmacology. 2024 Aug; 330(?):118240. doi: 10.1016/j.jep.2024.118240. [PMID: 38677574]
  • Katarzyna Dettlaff, Gabriela Anglart, Agnieszka Gruszczyńska, Anna Jelińska. Compatibility studies of selected multichamber bag parenteral nutrition with fluconazole. Nutrition (Burbank, Los Angeles County, Calif.). 2024 Jul; 123(?):112417. doi: 10.1016/j.nut.2024.112417. [PMID: 38593672]
  • Zahra Saeidi, Rashin Giti, Azadeh Emami, Mehdi Rostami, Farhad Mohammadi. Thermosensitive and mucoadhesive gels containing solid lipid nanoparticles loaded with fluconazole and niosomes loaded with clindamycin for the treatment of periodontal diseases: a laboratory experiment. BMC oral health. 2024 May; 24(1):551. doi: 10.1186/s12903-024-04322-6. [PMID: 38734599]
  • Hanna Stieber, Lara Junghanns, Hannah Wilhelm, Maria Batliner, Alexander Maximilian Aldejohann, Oliver Kurzai, Ronny Martin. The sphingolipid inhibitor myriocin increases Candida auris susceptibility to amphotericin B. Mycoses. 2024 Apr; 67(4):e13723. doi: 10.1111/myc.13723. [PMID: 38551121]
  • Fei Xie, Yumeng Hao, Yu Liu, Junhe Bao, Ruina Wang, Xiaochen Chi, Ting Wang, Shichong Yu, Yongsheng Jin, Liping Li, Yuanying Jiang, Dazhi Zhang, Lan Yan, Tingjunhong Ni. From Synergy to Monotherapy: Discovery of Novel 2,4,6-Trisubstituted Triazine Hydrazone Derivatives with Potent Antifungal Potency In Vitro and In Vivo. Journal of medicinal chemistry. 2024 Mar; 67(5):4007-4025. doi: 10.1021/acs.jmedchem.3c02292. [PMID: 38381075]
  • José Weverton Almeida-Bezerra, Rafael Pereira da Cruz, Viviane Bezerra da Silva, João Xavier Da Silva Neto, Larissa Alves Lopes de Souza, Daniele de Oliveira Bezerra de Sousa, Nadine Monteiro Salgueiro Araujo, Rafael Guimarães Gomes Silva, Blasco Quefi, Martinho Rau, Ricardo Andrade Rebelo, Sarah Castro Dos Santos, Luiz Everson da Silva, Henrique Douglas Melo Coutinho, Saulo Almeida Menezes, Maria Flaviana Bezerra Morais-Braga, Antonio Fernando Morais de Oliveira. Exploring the Fluconazole-Resistance Modifying Activity and Potential Mechanism of Action of Fixed Oil from Caryocar coriaceum Wittm. (Caryocaraceae) against Candida Species. Chemistry & biodiversity. 2024 Mar; 21(3):e202301960. doi: 10.1002/cbdv.202301960. [PMID: 38196022]
  • Viviane Bezerra da Silva, José Weverton Almeida-Bezerra, Maria Hellena Garcia Novais, Naiza Saraiva Farias, Janerson José Coelho, Paulo Riceli Vasconcelos Ribeiro, Kirley Marques Canuto, Henrique Douglas Melo Coutinho, Maria Flaviana Bezerra Morais-Braga, Antonio Fernando Morais de Oliveira. Chemical composition, antifungal, and anti-virulence action of the stem bark of Hancornia speciosa Gomes (Apocynaceae) against Candida spp. Journal of ethnopharmacology. 2024 Mar; 321(?):117506. doi: 10.1016/j.jep.2023.117506. [PMID: 38012976]
  • Rong-Shuai Li, Zhi-Chang Xu, Ding-Mei Qin, Jia-Bi Huang, Meng-Ru Wang, Xue-Rong Zhao, Quan-Yu Yang, Wei-Lie Xiao, Rui-Rui Wang, Xiao-Li Li. Three new diterpenoids isolated from Euphorbia nematocypha Hand.-Mazz and their anti-fungal activity. Natural product research. 2024 Feb; 38(5):838-847. doi: 10.1080/14786419.2023.2207134. [PMID: 37139787]
  • Guixiang Li, Binglu Ru, Ling Zhang, Yiwen Li, Xuheng Gao, Qin Peng, Jianqiang Miao, Xili Liu. Mefentrifluconazole-Resistant Risk and Resistance-Related Point Mutation in FpCYP51B of Fusarium pseudograminearum. Journal of agricultural and food chemistry. 2024 Jan; 72(3):1516-1526. doi: 10.1021/acs.jafc.3c08014. [PMID: 38194482]
  • Qin Peng, Xiuhuan Li, Guixiang Li, Xinchang Hao, Xili Liu. Resistance risk assessment of mefentrifluconazole in Corynespora cassiicola and the control of cucumber target spot by a two-way mixture of mefentrifluconazole and prochloraz. Pesticide biochemistry and physiology. 2024 Jan; 198(?):105719. doi: 10.1016/j.pestbp.2023.105719. [PMID: 38225065]
  • Hu Zhang, Juntao Wang, Mingrong Qian, Yuanxiang Jin. Mefentrifluconazole exposure disrupted hepatic lipid metabolism disorder tightly associated with gut barrier function abnormal in mice. The Science of the total environment. 2023 Dec; 905(?):167317. doi: 10.1016/j.scitotenv.2023.167317. [PMID: 37742980]
  • Liping Li, Hao Wu, Jiayin Wang, Zhe Ji, Ting Fang, Hui Lu, Lan Yan, Fuming Shen, Dazhi Zhang, Yuanying Jiang, Tingjunhong Ni. Discovery of Novel 8-Hydroxyquinoline Derivatives with Potent In Vitro and In Vivo Antifungal Activity. Journal of medicinal chemistry. 2023 Dec; 66(23):16364-16376. doi: 10.1021/acs.jmedchem.3c01771. [PMID: 37975824]
  • Niloufar Saber-Moghaddam, Mohammad Moeini Nodeh, Vahid Ghavami, Hossein Rahimi, Sajjad Ataei Azimi, Mohsen Seddigh-Shamsi, Mostafa Kamandi, Abolghasem Allahyari, Somayeh Sadat Shariatmaghani, Sepideh Elyasi, Omid Arasteh. The evaluation of atorvastatin as an adjunct to fluconazole for the anti-fungal prophylaxis in acute myeloid leukemia: a multicenter, triple-blinded, randomized clinical trial. Naunyn-Schmiedeberg's archives of pharmacology. 2023 Dec; ?(?):. doi: 10.1007/s00210-023-02892-w. [PMID: 38095652]
  • Shihao Song, Shuo Zhao, Xiuyun Sun, Lili Meng, Zijie Wang, Huihui Tan, Jingyun Liu, Min Zhang, Yinyue Deng. Anti-virulence strategy of diaryl chalcogenide compounds against Candida albicans infection. Virulence. 2023 12; 14(1):2265012. doi: 10.1080/21505594.2023.2265012. [PMID: 37771181]
  • Junhe Bao, Yumeng Hao, Tingjunhong Ni, Ruina Wang, Jiacun Liu, Xiaochen Chi, Ting Wang, Shichong Yu, Yongsheng Jin, Lan Yan, Xiaomei Li, Dazhi Zhang, Fei Xie. Design, synthesis and in vitro biological studies of novel triazoles with potent and broad-spectrum antifungal activity. Journal of enzyme inhibition and medicinal chemistry. 2023 Dec; 38(1):2244696. doi: 10.1080/14756366.2023.2244696. [PMID: 37553905]
  • Claudia Patricia Bravo-Chaucanés, Luis Carlos Chitiva, Yerly Vargas-Casanova, Valentina Diaz-Santoyo, Andrea Ximena Hernández, Geison M Costa, Claudia Marcela Parra-Giraldo. Exploring the Potential Mechanism of Action of Piperine against Candida albicans and Targeting Its Virulence Factors. Biomolecules. 2023 11; 13(12):. doi: 10.3390/biom13121729. [PMID: 38136600]
  • Guixiang Li, Ling Zhang, Huakai Wang, Xiuhuan Li, Fei Cheng, Jianqiang Miao, Qin Peng, Xili Liu. Resistance to the DMI fungicide mefentrifluconazole in Monilinia fructicola: risk assessment and resistance basis analysis. Pest management science. 2023 Nov; ?(?):. doi: 10.1002/ps.7909. [PMID: 38029343]
  • Nidal Jaradat. Qualitative and Quantitative Comparison of Aromatic Oil Components and Antifungal Effects of Cymbopogon flexuosus Obtained with Supercritical CO2, Microwave-Ultrasonic, Steam Distillation, and Hydrodistillation Extraction Techniques. Molecules (Basel, Switzerland). 2023 Sep; 28(19):. doi: 10.3390/molecules28196870. [PMID: 37836713]
  • Steven Kildea, Pierre Hellin, Thies M Heick, Stephen Byrne, Fiona Hutton. Mefentrifluconazole sensitivity amongst European Zymoseptoria tritici populations and potential implications for its field efficacy. Pest management science. 2023 Sep; ?(?):. doi: 10.1002/ps.7795. [PMID: 37759353]
  • Kevin Ehemann, Andrés Contreras, Adriana Marcela Celis-Ramírez. In vitro sensitivity of Malassezia furfur isolates from HIV-positive and negative patients to antifungal agents. Biomedica : revista del Instituto Nacional de Salud. 2023 Aug; 43(Sp. 1):120-131. doi: 10.7705/biomedica.6871. [PMID: 37721914]
  • Juliana Rizzo, Adèle Trottier, Frédérique Moyrand, Jean-Yves Coppée, Corinne Maufrais, Ana Claudia G Zimbres, Thi Tuong Vi Dang, Alexandre Alanio, Marie Desnos-Ollivier, Isabelle Mouyna, Gérard Péhau-Arnaude, Pierre-Henri Commere, Sophie Novault, Iuliana V Ene, Leonardo Nimrichter, Marcio L Rodrigues, Guilhem Janbon. Coregulation of extracellular vesicle production and fluconazole susceptibility in Cryptococcus neoformans. mBio. 2023 08; 14(4):e0087023. doi: 10.1128/mbio.00870-23. [PMID: 37310732]
  • David R Boulware, Mucunguzi Atukunda, Enock Kagimu, Abdu K Musubire, Andrew Akampurira, Lillian Tugume, Kenneth Ssebambulidde, John Kasibante, Laura Nsangi, Timothy Mugabi, Jane Gakuru, Sarah Kimuda, Derrick Kasozi, Suzan Namombwe, Isaac Turyasingura, Morris K Rutakingirwa, Edward Mpoza, Enos Kigozi, Conrad Muzoora, Jayne Ellis, Caleb P Skipper, Theresa Matkovits, Peter R Williamson, Darlisha A Williams, Ann Fieberg, Kathy H Hullsiek, Mahsa Abassi, Biyue Dai, David B Meya. Oral Lipid Nanocrystal Amphotericin B for Cryptococcal Meningitis: A Randomized Clinical Trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2023 Aug; ?(?):. doi: 10.1093/cid/ciad440. [PMID: 37606364]
  • Lin Du, Saikat Haldar, Jarrod B King, Allison O Mattes, Shikha Srivastava, Karen L Wendt, Jianlan You, Chad Cunningham, Robert H Cichewicz. Persephacin Is a Broad-Spectrum Antifungal Aureobasidin Metabolite That Overcomes Intrinsic Resistance in Aspergillus fumigatus. Journal of natural products. 2023 Jul; ?(?):. doi: 10.1021/acs.jnatprod.3c00382. [PMID: 37523665]
  • Hau Lam Choy, Elizabeth A Gaylord, Tamara L Doering. Ergosterol distribution controls surface structure formation and fungal pathogenicity. mBio. 2023 Jul; ?(?):e0135323. doi: 10.1128/mbio.01353-23. [PMID: 37409809]
  • Raimundo Samuel Leite Sampaio, Raimundo Luiz Silva Pereira, Henrique Douglas Melo Coutinho, José Weverton Almeida-Bezerra, Maria Flaviana Bezerra Morais-Braga, Mariana Dos Santos Santana, Maria Elenilda Paulino da Silva, Antonia Thassya Lucas Dos Santos, Victor Juno Alencar Fonseca, Adrielle Rodrigues Costa, Viviane Bezerra da Silva, Felicidade Caroline Rodrigues, José Jailson Lima Bezerra, António Raposo, João Paulo Martins de Lima, Luiz Marivando Barros. Chemical composition and antimicrobial potential of Acrocomia aculeata (Jacq.) Lodd. ex Mart. and Syagrus cearensis Noblick (Arecaceae). Microbial pathogenesis. 2023 Jul; 180(?):106147. doi: 10.1016/j.micpath.2023.106147. [PMID: 37169312]
  • Renle Xu, Kun Chen, Xu Han, Yuhang Lou, Shihao Gu, Yanqing Gao, Shibin Shang, Zhanqian Song, Jie Song, Jian Li. Design and Synthesis of Antifungal Candidates Containing Triazole Scaffold from Natural Rosin against Valsa mali for Crop Protection. Journal of agricultural and food chemistry. 2023 Jun; 71(25):9718-9727. doi: 10.1021/acs.jafc.3c02002. [PMID: 37318049]
  • Meng Zhang, Pu-Ting Dong, Hassan E Eldesouky, Yuewei Zhan, Haonan Lin, Zian Wang, Ehab A Salama, Sebastian Jusuf, Cheng Zong, Zhicong Chen, Mohamed N Seleem, Ji-Xin Cheng. Fingerprint Stimulated Raman Scattering Imaging Unveils Ergosteryl Ester as a Metabolic Signature of Azole-Resistant Candida albicans. Analytical chemistry. 2023 Jun; ?(?):. doi: 10.1021/acs.analchem.3c00900. [PMID: 37310727]
  • Matúš Štefánek, Martina Garaiová, Adam Valček, Luisa Jordao, Helena Bujdáková. Comparative Analysis of Two Candida parapsilosis Isolates Originating from the Same Patient Harbouring the Y132F and R398I Mutations in the ERG11 Gene. Cells. 2023 06; 12(12):. doi: 10.3390/cells12121579. [PMID: 37371049]
  • Fei Xie, Yumeng Hao, Liping Li, Ruina Wang, Junhe Bao, Xiaochen Chi, Brian C Monk, Ting Wang, Shichong Yu, Yongsheng Jin, Dazhi Zhang, Tingjunhong Ni, Lan Yan. Novel antifungal triazoles with alkynyl-methoxyl side chains: Design, synthesis, and biological activity evaluation. European journal of medicinal chemistry. 2023 May; 257(?):115506. doi: 10.1016/j.ejmech.2023.115506. [PMID: 37216811]
  • Feng Yang, Eduardo F C Scopel, Hao Li, Liu-Liu Sun, Nora Kawar, Yong-Bing Cao, Yuan-Ying Jiang, Judith Berman. Antifungal Tolerance and Resistance Emerge at Distinct Drug Concentrations and Rely upon Different Aneuploid Chromosomes. mBio. 2023 04; 14(2):e0022723. doi: 10.1128/mbio.00227-23. [PMID: 36877011]
  • Sivaraman Dhanasekaran, Pradeep Pushparaj Selvadoss, Solomon Sundar Manoharan, Srikanth Jeyabalan, Vijayarangan Devi Rajeswari. Revealing anti-fungal potential of plant-derived bioactive therapeutics in targeting secreted aspartyl proteinase (SAP) of Candida albicans: a molecular dynamics approach. Journal of biomolecular structure & dynamics. 2023 Apr; ?(?):1-15. doi: 10.1080/07391102.2023.2196703. [PMID: 37021476]
  • Ka Pui Sharon Yau, Harshini Weerasinghe, Francios A B Olivier, Tricia L Lo, David R Powell, Barbara Koch, Traude H Beilharz, Ana Traven. The proteasome regulator Rpn4 controls antifungal drug tolerance by coupling protein homeostasis with metabolic responses to drug stress. PLoS pathogens. 2023 Apr; 19(4):e1011338. doi: 10.1371/journal.ppat.1011338. [PMID: 37075064]
  • Ahmed Jibrin Uttu, Muhammad Sani Sallau, Hamisu Ibrahim, Ogunkemi Risikat Agbeke Iyun. In silico modelling and NMR Characterization of some steroids from Strychnos innocua (Delile) root bark as potential antifungal agents. Steroids. 2023 Mar; 194(?):109222. doi: 10.1016/j.steroids.2023.109222. [PMID: 36924816]
  • Kai-Fan Hu, Ling Mo, Hao Zhang, Dan Xia, Gao-Xiang Shi, Da-Qiang Wu, Tian-Ming Wang, Jing Shao, Chang-Zhong Wang. [Mechanism of n-butanol alcohol extract of Baitouweng Decoction in treatment of vulvovaginal candidiasis based on negative regulation of NLRP3 inflammasome via PKCδ/NLRC4/IL-1Ra axis]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2023 Mar; 48(6):1578-1588. doi: 10.19540/j.cnki.cjcmm.20221110.701. [PMID: 37005846]
  • Luz Dary Caicedo-Bejarano, Lizeth Stefania Osorio-Vanegas, Mauricio Ramírez-Castrillón, Jorge Enrique Castillo, Carlos Andrés Martínez-Garay, Mónica Chávez-Vivas. Water Quality, Heavy Metals, and Antifungal Susceptibility to Fluconazole of Yeasts from Water Systems. International journal of environmental research and public health. 2023 02; 20(4):. doi: 10.3390/ijerph20043428. [PMID: 36834128]
  • Xiaoyu Ma, Chenxi Li, Lan Ma, Xuan Zhao, Yanjie Liu, Xiaoran Hao, Ping Zhang, Xudong Zhu. RNAi machinery regulates nutrient metabolism and fluconazole resistance in the pathogenic fungus Cryptococcus deneoformans. Medical mycology. 2023 Feb; 61(2):. doi: 10.1093/mmy/myac095. [PMID: 36496203]
  • Letícia Kraft, Victoria Stadler Tasca Ribeiro, Geiziane Aparecida Gonçalves, Paula Hansen Suss, Felipe Francisco Tuon. Comparison of amphotericin B lipid complex, deoxycholate amphotericin B, fluconazole, and anidulafungin activity against Candida albicans biofilm isolated from breakthrough candidemia. Enfermedades infecciosas y microbiologia clinica (English ed.). 2023 Jan; ?(?):. doi: 10.1016/j.eimce.2022.07.009. [PMID: 36707288]
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