cathinone (BioDeep_00000001447)

 

Secondary id: BioDeep_00000173189, BioDeep_00000526524


代谢物信息卡片


2-Aminopropiophenone

化学式: C9H11NO (149.0840596)
中文名称: 开思酮, 卡西酮
谱图信息: 最多检出来源 Viridiplantae(plant) 0.05%

分子结构信息

SMILES: CC(C(=O)C1=CC=CC=C1)N
InChI: InChI=1S/C9H11NO/c1-7(10)9(11)8-5-3-2-4-6-8/h2-7H,10H2,1H3

描述信息

D002491 - Central Nervous System Agents > D000697 - Central Nervous System Stimulants
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs
C78272 - Agent Affecting Nervous System > C47795 - CNS Stimulant
The S stereoisomer of 2-aminopropiophenone.

同义名列表

3 个代谢物同义名

cathinone; 2-Aminopropiophenone; D-Cathinone



数据库引用编号

19 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(1)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(1)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

8 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Ahmad M Alamir, Mohammed A Jeraiby, Hesham M Korashy, Emad Sayed Shaheen, Mohammad A Attafi, Magbool E Oraiby, Ahmed M Hakami, Mohammed Y Albeishy, Ibrahim A Khardali, Ismail A Juraybi, Abeer A Alobaida, Ibraheem M Attafi. Cathine and cathinone disposition kinetics and neurotransmitter profile in several organs of rats exposed to a single dose of Catha edulis (Vahl) Forssk. ex Endl. extract. Drug metabolism and personalized therapy. 2023 Mar; ?(?):. doi: 10.1515/dmpt-2022-0154. [PMID: 36883753]
  • Ya-Ling Yeh, Sheng-Meng Wang. Quantitative determination and metabolic profiling of synthetic cathinone eutylone in vitro and in urine samples by liquid chromatography tandem quadrupole time-of-flight mass spectrometry. Drug testing and analysis. 2022 Jul; 14(7):1325-1337. doi: 10.1002/dta.3258. [PMID: 35332690]
  • Chang Han, Dongqin Tan, Yue Wang, Zhonglin Yu, Xiaoli Sun, Degao Wang. Selective extraction of synthetic cathinones new psychoactive substances from wastewater, urine and cocktail using dummy molecularly imprinted polymers. Journal of pharmaceutical and biomedical analysis. 2022 Jun; 215(?):114765. doi: 10.1016/j.jpba.2022.114765. [PMID: 35447493]
  • Isabel Gomila Muñiz, Elena Lendoiro, Ana de-Castro-Ríos, Miguel Ángel Elorza Guerrero, Jordi Puiguriguer Ferrando, Laura Sahuquillo Frias, Pilar Sanchís Cortés, Bernardino Barceló Martín. Detection of unsuspected cathinone and piperazine-type drugs in urine samples positive for methamphetamine and amphetamine collected in emergency departments. Emergencias : revista de la Sociedad Espanola de Medicina de Emergencias. 2022 06; 34(3):174-180. doi: . [PMID: 35736521]
  • Changbao Hong, Ying Dong, Ruiqin Zhu, Yibo Yan, Xiantao Shen, Stig Pedersen-Bjergaard, Chuixiu Huang. Effect of sample matrices on supported liquid membrane: Efficient electromembrane extraction of cathinones from biological samples. Talanta. 2022 Apr; 240(?):123175. doi: 10.1016/j.talanta.2021.123175. [PMID: 34972062]
  • Jennifer M Hobbs, Rebecca T DeRienz, Daniel D Baker, Morgan R Shuttleworth, Maneesha Pandey. Fatal Intoxication by the Novel Cathinone 4-Fluoro-3-methyl-α-PVP. Journal of analytical toxicology. 2022 Mar; 46(3):e101-e104. doi: 10.1093/jat/bkac003. [PMID: 35020879]
  • André Niebel, Fritz Pragst, Franziska Krumbiegel, Sven Hartwig. Prevalence of cathinones and other new psychoactive substances in hair of parents and children of families with known or suspected parental abuse of conventional illegal drugs. Forensic science international. 2022 Feb; 331(?):111148. doi: 10.1016/j.forsciint.2021.111148. [PMID: 34923263]
  • Julie A Marusich, Elaine A Gay, Delisha A Stewart, Bruce E Blough. Sex differences in inflammatory cytokine levels following synthetic cathinone self-administration in rats. Neurotoxicology. 2022 01; 88(?):65-78. doi: 10.1016/j.neuro.2021.11.002. [PMID: 34742947]
  • Yawen Li, Ru Lian, Feiyu Yang, Zhiru Xu, Fangqi Cao, Rong Wang, Chen Liang, Yurong Zhang. Rapid quantitation of three synthetic cathinones in urine by magnetic dispersive solid-phase extraction combined with DART-HRMS. Analytical methods : advancing methods and applications. 2021 11; 13(42):5048-5055. doi: 10.1039/d1ay01280k. [PMID: 34647545]
  • Courtney Gearlds, Jessica Brooke Bouldin, Mariah McKinney, Shannon Schreiner, Stacy D Brown, Brooks B Pond. Pharmacokinetics of Synthetic Cathinones Found in Bath Salts in Mouse Brain and Plasma Using High-Pressure Liquid Chromatography-Tandem Mass Spectrometry. European journal of drug metabolism and pharmacokinetics. 2021 Nov; 46(6):771-778. doi: 10.1007/s13318-021-00712-1. [PMID: 34427910]
  • Jorge Soares, Vera Marisa Costa, Maria de Lourdes Bastos, Félix Carvalho, João Paulo Capela. An updated review on synthetic cathinones. Archives of toxicology. 2021 09; 95(9):2895-2940. doi: 10.1007/s00204-021-03083-3. [PMID: 34100120]
  • Jiahua Ji, Ying Zhang, Jifen Wang. Rapid detection of nine synthetic cathinones in blood and urine by direct analysis in real-time-tandem mass spectrometry. Rapid communications in mass spectrometry : RCM. 2021 Aug; 35(15):e9136. doi: 10.1002/rcm.9136. [PMID: 34080240]
  • Karolina E Kolaczynska, Jan Thomann, Marius C Hoener, Matthias E Liechti. The Pharmacological Profile of Second Generation Pyrovalerone Cathinones and Related Cathinone Derivative. International journal of molecular sciences. 2021 Jul; 22(15):. doi: 10.3390/ijms22158277. [PMID: 34361040]
  • Piotr Adamowicz. Blood concentrations of synthetic cathinones. Clinical toxicology (Philadelphia, Pa.). 2021 07; 59(7):648-654. doi: 10.1080/15563650.2020.1848100. [PMID: 33263455]
  • Devan Loganathan, Rong Yi, Bhavesh Patel, Julia Zhang, Noel Kong. A sensitive HPLC-MS/MS method for the detection, resolution and quantitation of cathinone enantiomers in horse blood plasma and urine. Analytical and bioanalytical chemistry. 2021 Mar; 413(8):2147-2161. doi: 10.1007/s00216-021-03182-1. [PMID: 33517480]
  • Fernando B de Moura, Alexander Sherwood, Thomas E Prisinzano, Carol A Paronis, Jack Bergman, Stephen J Kohut. Reinforcing effects of synthetic cathinones in rhesus monkeys: Dose-response and behavioral economic analyses. Pharmacology, biochemistry, and behavior. 2021 03; 202(?):173112. doi: 10.1016/j.pbb.2021.173112. [PMID: 33444603]
  • Rossella Gottardo, Daniela Sorio, Giulia Soldati, Marco Ballotari, Nadia Maria Porpiglia, Franco Tagliaro. Optimization and validation of a new approach based on CE-HRMS for the screening analysis of novel psychoactive substances (cathinones, phenethylamines, and tryptamines) in urine. Electrophoresis. 2021 02; 42(4):450-459. doi: 10.1002/elps.202000304. [PMID: 33263181]
  • Elisabeth Pendl, Udo Pauritsch, Manfred Kollroser, Martin G Schmid. Determination of cathinone and cathine in Khat plant material by LC-MS/MS: Fresh vs. dried leaves. Forensic science international. 2021 Feb; 319(?):110658. doi: 10.1016/j.forsciint.2020.110658. [PMID: 33370655]
  • Nathalie Cartiser, Anaïs Sahy, Anne-Sophie Advenier, Angélique Franchi, Kevin Revelut, Charline Bottinelli, Fabien Bévalot, Laurent Fanton. Fatal intoxication involving 4-methylpentedrone (4-MPD) in a context of chemsex. Forensic science international. 2021 Feb; 319(?):110659. doi: 10.1016/j.forsciint.2020.110659. [PMID: 33370656]
  • Abdulaziz A Aldubayyan, Erika Castrignanò, Simon Elliott, Vincenzo Abbate. Stability of synthetic cathinones in clinical and forensic toxicological analysis-Where are we now?. Drug testing and analysis. 2021 Jan; 13(1):44-68. doi: 10.1002/dta.2990. [PMID: 33283466]
  • Jeremy Carlier, Xingxing Diao, Raffaele Giorgetti, Francesco P Busardò, Marilyn A Huestis. Pyrrolidinyl Synthetic Cathinones α-PHP and 4F-α-PVP Metabolite Profiling Using Human Hepatocyte Incubations. International journal of molecular sciences. 2020 Dec; 22(1):. doi: 10.3390/ijms22010230. [PMID: 33379373]
  • Joana Carrola, Noélia Duarte, Pedro Florindo, Sara Henriques, Gustavo da Silva, Lubertus Bijlsma, Rui Moreira, Catarina Correia, Maria de Jesus Perry, Álvaro Lopes, Cristina de Mello-Sampayo, Maria do Rosário Bronze. Metabolism of N-ethylhexedrone and buphedrone: An in vivo study in mice using HPLC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Nov; 1159(?):122340. doi: 10.1016/j.jchromb.2020.122340. [PMID: 32905991]
  • Anastasia Alexandridou, Thomai Mouskeftara, Nikolaos Raikos, Helen G Gika. GC-MS analysis of underivatised new psychoactive substances in whole blood and urine. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2020 Nov; 1156(?):122308. doi: 10.1016/j.jchromb.2020.122308. [PMID: 33038866]
  • Shu-Yu Fan, Chi-Zong Zang, Po-Han Shih, Ya-Chun Ko, Ya-Hui Hsu, Mei-Chih Lin, Su-Hsiang Tseng, Der-Yuan Wang. A LC-MS/MS method for determination of 73 synthetic cathinones and related metabolites in urine. Forensic science international. 2020 Oct; 315(?):110429. doi: 10.1016/j.forsciint.2020.110429. [PMID: 32784041]
  • I Vaz, T Carvalho, M J Valente, A Castro, A M Araújo, M L Bastos, M Carvalho. The interplay between autophagy and apoptosis mediates toxicity triggered by synthetic cathinones in human kidney cells. Toxicology letters. 2020 Oct; 331(?):42-52. doi: 10.1016/j.toxlet.2020.05.025. [PMID: 32464236]
  • Pierce Kavanagh, Mariia Gofenberg, Vadim Shevyrin, Oksana Dvorskaya, Geraldine Dowling, Andrej Grigoryev. Tentative identification of the phase I and II metabolites of two synthetic cathinones, MDPHP and α-PBP, in human urine. Drug testing and analysis. 2020 Oct; 12(10):1442-1451. doi: 10.1002/dta.2891. [PMID: 32621389]
  • Hannes M Schwelm, Christina Grumann, Volker Auwärter, Merja A Neukamm. Application of a chiral high-performance liquid chromatography-tandem mass spectrometry method for the determination of 13 related amphetamine-type stimulants to forensic samples: Interpretative hypotheses. Drug testing and analysis. 2020 Sep; 12(9):1354-1365. doi: 10.1002/dta.2886. [PMID: 32589765]
  • David Fabregat-Safont, Daniela Felis-Brittes, Maria Mata-Pesquera, Juan V Sancho, Félix Hernández, María Ibáñez. Direct and Fast Screening of New Psychoactive Substances Using Medical Swabs and Atmospheric Solids Analysis Probe Triple Quadrupole with Data-Dependent Acquisition. Journal of the American Society for Mass Spectrometry. 2020 Jul; 31(7):1610-1614. doi: 10.1021/jasms.0c00112. [PMID: 32464059]
  • Albert Pérez-Alcaraz, Francesc Borrull, Marta Calull, Carme Aguilar. Field-amplified sample injection combined with CE for the enantiodetermination of cathinones in urine samples. Journal of separation science. 2020 Jul; 43(14):2914-2924. doi: 10.1002/jssc.201901067. [PMID: 32339380]
  • Ana Carolina Faria, Helena Carmo, Félix Carvalho, João Pedro Silva, Maria de Lourdes Bastos, Diana Dias da Silva. Drinking to death: Hyponatraemia induced by synthetic phenethylamines. Drug and alcohol dependence. 2020 07; 212(?):108045. doi: 10.1016/j.drugalcdep.2020.108045. [PMID: 32460203]
  • Ewelina Pieprzyca, Rafał Skowronek, Ľuboš Nižnanský, Piotr Czekaj. Synthetic cathinones - From natural plant stimulant to new drug of abuse. European journal of pharmacology. 2020 May; 875(?):173012. doi: 10.1016/j.ejphar.2020.173012. [PMID: 32087255]
  • Bárbara Silva, Renata Silva, Carla Fernandes, Paula Guedes de Pinho, Fernando Remião. Enantioselectivity on the absorption of methylone and pentedrone using Caco-2 cell line: Development and validation of an UHPLC method for cathinones quantification. Toxicology and applied pharmacology. 2020 05; 395(?):114970. doi: 10.1016/j.taap.2020.114970. [PMID: 32234388]
  • Kai-Wen Cheng, Chien-Ming Hsieh, Huei-Wen Chen, Pin-Chieh Chi, Da-Peng Yang, She-Hung Chan, Ju-Yu Chen, Hsaio-Lin Hwa, Cheng-Chung Fang, Te-I Weng, Pai-Shan Chen. Determination of synthetic cathinone α-pyrrolidinovalero-phenone and its metabolite in urine using solid-phase extraction and gas chromatography-mass spectrometry. Rapid communications in mass spectrometry : RCM. 2020 Apr; 34 Suppl 1(?):e8579. doi: 10.1002/rcm.8579. [PMID: 31502287]
  • Anthony L Riley, Katharine H Nelson, Peter To, Raul López-Arnau, Peng Xu, Dan Wang, Youmei Wang, Hao-Wei Shen, Donald M Kuhn, Mariana Angoa-Perez, John H Anneken, Dawn Muskiewicz, F Scott Hall. Abuse potential and toxicity of the synthetic cathinones (i.e., "Bath salts"). Neuroscience and biobehavioral reviews. 2020 03; 110(?):150-173. doi: 10.1016/j.neubiorev.2018.07.015. [PMID: 31101438]
  • Abdulrhman M Dhabbah. Determination of chiral cathinone in fresh samples of Catha edulis. Forensic science international. 2020 Feb; 307(?):110105. doi: 10.1016/j.forsciint.2019.110105. [PMID: 31915111]
  • A E Gareeva, U G Badretdinov, E A Akhmetova, K O Kinyasheva, T R Nasibullin, L I Samigullina, I F Timerbulatov, M F Timerbulatova, A R Asadullin. [The role of genetic factors in the development of suicidal behavior in individuals with dependence on synthetic cathinones]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova. 2020; 120(10):69-77. doi: 10.17116/jnevro202012010169. [PMID: 33244961]
  • Barkha J Yadav-Samudrala, Jose M Eltit, Richard A Glennon. Synthetic Cathinone Analogues Structurally Related to the Central Stimulant Methylphenidate as Dopamine Reuptake Inhibitors. ACS chemical neuroscience. 2019 09; 10(9):4043-4050. doi: 10.1021/acschemneuro.9b00284. [PMID: 31369229]
  • Yao-Te Yen, Ting-Yueh Chen, Chun-Yu Chen, Chi-Lun Chang, San-Chong Chyueh, Huan-Tsung Chang. A Photoluminescent Colorimetric Probe of Bovine Serum Albumin-Stabilized Gold Nanoclusters for New Psychoactive Substances: Cathinone Drugs in Seized Street Samples. Sensors (Basel, Switzerland). 2019 Aug; 19(16):. doi: 10.3390/s19163554. [PMID: 31443204]
  • João L Gonçalves, Vera L Alves, Joselin Aguiar, Helena M Teixeira, José S Câmara. Synthetic cathinones: an evolving class of new psychoactive substances. Critical reviews in toxicology. 2019 08; 49(7):549-566. doi: 10.1080/10408444.2019.1679087. [PMID: 31747318]
  • Weijuan Yang, Haixiang Yu, Obtin Alkhamis, Yingzhu Liu, Juan Canoura, Fengfu Fu, Yi Xiao. In vitro isolation of class-specific oligonucleotide-based small-molecule receptors. Nucleic acids research. 2019 07; 47(12):e71. doi: 10.1093/nar/gkz224. [PMID: 30926988]
  • Katalin Kovács, Éva Kereszty, Róbert Berkecz, László Tiszlavicz, Éva Sija, Tímea Körmöczi, Nikolett Jenei, Hajnal Révész-Schmehl, László Institóris. Fatal intoxication of a regular drug user following N-ethyl-hexedrone and ADB-FUBINACA consumption. Journal of forensic and legal medicine. 2019 Jul; 65(?):92-100. doi: 10.1016/j.jflm.2019.04.012. [PMID: 31128567]
  • Albert Pérez-Alcaraz, Francesc Borrull, Carme Aguilar, Marta Calull. Enantioselective determination of cathinones in urine by high pressure in-line SPE-CE. Electrophoresis. 2019 07; 40(14):1762-1770. doi: 10.1002/elps.201900072. [PMID: 31093983]
  • Sharoen Yu Ming Lim, Athira Rafhana Binti Azidin, Yee Tze Ung, Mustafa Al-Shagga, Mohammed Abdullah Alshawsh, Zahurin Mohamed, Chin Eng Ong, Yan Pan. Effect of 95\% Ethanol Khat Extract and Cathinone on in vitro Human Recombinant Cytochrome P450 (CYP) 2C9, CYP2D6, and CYP3A4 Activity. European journal of drug metabolism and pharmacokinetics. 2019 Jun; 44(3):423-431. doi: 10.1007/s13318-018-0518-2. [PMID: 30306496]
  • Mohammed A Meetani, Rashed H Alremeithi, Muath K Mousa. Enantioseparation of Synthetic Cathinones Enantiomers with Tertiary Amine Structure in Urine and Plasma. Journal of chromatographic science. 2019 Apr; 57(4):361-368. doi: 10.1093/chromsci/bmz008. [PMID: 30753330]
  • Enrico Gerace, Denise Caneparo, Federica Borio, Alberto Salomone, Marco Vincenti. Determination of several synthetic cathinones and an amphetamine-like compound in urine by gas chromatography with mass spectrometry. Method validation and application to real cases. Journal of separation science. 2019 Apr; 42(8):1577-1584. doi: 10.1002/jssc.201801249. [PMID: 30740888]
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