Baclofen (BioDeep_00000001426)

 

Secondary id: BioDeep_00000016555, BioDeep_00001868423

human metabolite PANOMIX_OTCML-2023 blood metabolite


代谢物信息卡片


beta-(Aminomethyl)-4-chlorobenzenepropanoic acid

化学式: C10H12ClNO2 (213.0556522)
中文名称: 巴氯酚, 巴氯芬, (R)-巴氯芬(mM/ml)
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 0.64%

分子结构信息

SMILES: C1=CC(=CC=C1C(CC(=O)O)CN)Cl
InChI: InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)

描述信息

Baclofen is a gamma-amino-butyric acid (GABA) derivative used as a skeletal muscle relaxant. Baclofen stimulates GABA-B receptors leading to decreased frequency and amplitude of muscle spasms. It is especially useful in treating muscle spasticity associated with spinal cord injury. It appears to act primarily at the spinal cord level by inhibiting spinal polysynaptic afferent pathways and, to a lesser extent, monosynaptic afferent pathways.
M - Musculo-skeletal system > M03 - Muscle relaxants > M03B - Muscle relaxants, centrally acting agents
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018755 - GABA Agonists
D018373 - Peripheral Nervous System Agents > D009465 - Neuromuscular Agents
C78281 - Agent Affecting Musculoskeletal System > C29696 - Muscle Relaxant
D002491 - Central Nervous System Agents
(R)-Baclofen (Arbaclofen) is a selective GABAB receptor agonist[1].
Baclofen, a lipophilic derivative of γ-aminobutyric acid (GABA), is an orally active, selective metabotropic GABAB receptor (GABABR) agonist. Baclofen mimics the action of GABA and produces slow presynaptic inhibition through the GABAB receptor. Baclofen has high blood brain barrier penetrance. Baclofen has the potential for muscle spasticity research[1][2][3].

同义名列表

96 个代谢物同义名

beta-(Aminomethyl)-4-chlorobenzenepropanoic acid; b-(Aminomethyl)-4-chlorobenzenepropanoic acid; beta-(p-Chlorophenyl)-gamma-aminobutyric acid; beta-(Aminomethyl)-p-chlorohydrocinnamic acid; gamma-Amino-beta-(p-chlorophenyl)butyric acid; Β-(aminomethyl)-4-chlorobenzenepropanoic acid; beta-(Aminomethyl)-4-chlorobenzenepropanoate; Β-(aminomethyl)-p-chlorohydrocinnamic acid; b-(Aminomethyl)-p-chlorohydrocinnamic acid; beta-(Aminomethyl)-p-chlorohydrocinnamate; b-(Aminomethyl)-4-chlorobenzenepropanoate; gamma-Amino-beta-(p-chlorophenyl)butyrate; beta-(p-Chlorophenyl)-gamma-aminobutyrate; Β-(aminomethyl)-4-chlorobenzenepropanoate; DL-4-Amino-3-p-chlorophenylbutanoic acid; 4-amino-3-(4-chlorophenyl)butanoic acid; g-Amino-b-(p-chlorophenyl)butyric acid; Γ-amino-β-(p-chlorophenyl)butyric acid; Β-(p-chlorophenyl)-γ-aminobutyric acid; 4-Amino-3-(4-chlorophenyl)butyric acid; Β-(aminomethyl)-p-chlorohydrocinnamate; b-(p-Chlorophenyl)-g-aminobutyric acid; b-(Aminomethyl)-p-chlorohydrocinnamate; DL-4-Amino-3-p-chlorophenylbutanoate; g-Amino-b-(p-chlorophenyl)butyrate; 4-Amino-3-(4-chlorophenyl)butyrate; b-(p-Chlorophenyl)-g-aminobutyrate; Γ-amino-β-(p-chlorophenyl)butyrate; Β-(p-chlorophenyl)-γ-aminobutyrate; Pharmascience brand OF baclofen; ASTA medica brand OF baclofen; Alphapharm brand OF baclofen; Ciba-geigy brand OF baclofen; Ciba geigy brand OF baclofen; Baclofen pharmascience brand; Medtronic brand OF baclofen; Ashbourne brand OF baclofen; Nu pharm brand OF baclofen; Nu-pharm brand OF baclofen; Novartis brand OF baclofen; Baclofen ciba-geigy brand; Baclofen alphapharm brand; beta-(4-Chlorophenyl)gaba; Athena brand OF baclofen; Baclofen medtronic brand; Baclofen ashbourne brand; Apotex brand OF baclofen; Baclofen nu-pharm brand; Baclofen novartis brand; Irex brand OF baclofen; Isis brand OF baclofen; b-(4-Chlorophenyl)gaba; Β-(4-chlorophenyl)gaba; Baclofen apotex brand; Baclofen athena brand; Baclofen isis brand; Baclofen irex brand; GABA, chlorophenyl; Chlorophenyl gaba; CIBA-34,647-ba; Baclofène-irex; Baclofène irex; AWD, baclofen; BaclofèneIrex; (+-)-Baclofen; CIBA34,647ba; Gen-baclofen; PMS Baclofen; Baclofen awd; apo-Baclofen; Gen baclofen; apo Baclofen; PMS-Baclofen; (R)-Baclofen; ApoBaclofen; GenBaclofen; PMSBaclofen; DL-Baclofen; Arbaclofen; Baclofenum; Baclofene; Baclophen; Baclospas; Baclofeno; Nu baclo; PCP-GABA; Genpharm; Baclofen; Lioresal; Nu-baclo; Atrofen; Kemstro; NuBaclo; Clofen; Lebic; STX209



数据库引用编号

21 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Xiaoju Liu, Haijuan Wang, Xiaoyu Wang, Yinxia Ning, Wei Liu, Jie Gao. Baixiangdan capsule and Shuyu capsule regulate anger-out and anger-in, respectively: GB1-mediated GABA can regulate 5-HT levels in multiple brain regions. Aging. 2023 Mar; 15(6):2046-2065. doi: 10.18632/aging.204589. [PMID: 36988497]
  • Thomas John Pisano, Jessica Ace, Beverly Hon. Transient alteration of consciousness in spinal cord injury secondary to Baclofen use: a case report. Spinal cord series and cases. 2022 05; 8(1):56. doi: 10.1038/s41394-022-00511-z. [PMID: 35597797]
  • Dani C Mata, John F Davis. Simultaneous quantitative analysis of 39 common toxicological drugs for increased efficiency in an ante- and postmortem laboratory. Forensic science international. 2022 May; 334(?):111246. doi: 10.1016/j.forsciint.2022.111246. [PMID: 35276541]
  • Bryan VanDreese, Ashley Holland, Andrew Murray. Chronic Phenibut Use: Symptoms, Severe Withdrawal, and Recovery. WMJ : official publication of the State Medical Society of Wisconsin. 2022 Apr; 121(1):E1-E4. doi: . [PMID: 35442585]
  • Ning Li, Wucheng Tao, Liu Yang, William J Spain, Christopher B Ransom. GABA-B receptors enhance GABA-A receptor currents by modulation of membrane trafficking in dentate gyrus granule cells. Neuroscience letters. 2022 03; 773(?):136481. doi: 10.1016/j.neulet.2022.136481. [PMID: 35104617]
  • Steven E Epstein, Kate Hopper, Kate S Farrell. Manual plasma exchange to treat an accidental overdose of intravenous lipid emulsion in a dog with baclofen toxicosis. Journal of the American Veterinary Medical Association. 2022 01; 260(6):650-656. doi: 10.2460/javma.21.03.0152. [PMID: 35066487]
  • Resha Khanal, Sharad Oli, Janet Chan Gomez, Sahar Tahir, Binita Bhandari, Saketram Komanduri. Severe Case of Oral Baclofen Withdrawal Resulting in Mechanical Ventilation. Journal of investigative medicine high impact case reports. 2022 Jan; 10(?):23247096211060584. doi: 10.1177/23247096211060584. [PMID: 35356848]
  • Tzu-Yu Lin, Cheng-Wei Lu, Pei-Wen Hsieh, Kuan-Ming Chiu, Ming-Yi Lee, Su-Jane Wang. Natural Product Isoliquiritigenin Activates GABAB Receptors to Decrease Voltage-Gate Ca2+ Channels and Glutamate Release in Rat Cerebrocortical Nerve Terminals. Biomolecules. 2021 10; 11(10):. doi: 10.3390/biom11101537. [PMID: 34680170]
  • Marc Ghannoum, Ingrid Berling, Valéry Lavergne, Darren M Roberts, Tais Galvao, Robert S Hoffman, Thomas D Nolin, Andrew Lewington, Kent Doi, Sophie Gosselin. Recommendations from the EXTRIP workgroup on extracorporeal treatment for baclofen poisoning. Kidney international. 2021 10; 100(4):720-736. doi: 10.1016/j.kint.2021.07.014. [PMID: 34358487]
  • Emma E J Kasteel, Leonie S Lautz, Maxime Culot, Nynke I Kramer, Anne Zwartsen. Application of in vitro data in physiologically-based kinetic models for quantitative in vitro-in vivo extrapolation: A case-study for baclofen. Toxicology in vitro : an international journal published in association with BIBRA. 2021 Oct; 76(?):105223. doi: 10.1016/j.tiv.2021.105223. [PMID: 34293430]
  • Flory T Muanda, Peter G Blake, Matthew A Weir, Lavanya Bathini, Kianna Chauvin, Stephanie N Dixon, Eric McArthur, Jessica M Sontrop, Louise Moist, Richard B Kim, Amit X Garg. Association of Baclofen With Falls and Fractures in Patients With CKD. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2021 09; 78(3):470-473. doi: 10.1053/j.ajkd.2020.12.017. [PMID: 33581166]
  • Megan Pelter, Samantha R S Bagsic, Laura Nicholson. Oral baclofen toxicity in older patients with chronic kidney disease. Journal of the American Geriatrics Society. 2021 08; 69(8):2352-2354. doi: 10.1111/jgs.17168. [PMID: 33856687]
  • Satoru Mitsuboshi. Association Between Baclofen and Respiratory Depression in Patients With Chronic Kidney Disease. Journal of clinical pharmacology. 2021 06; 61(6):836-837. doi: 10.1002/jcph.1843. [PMID: 33629349]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Ahmed A Abu-Hassan, Ramadan Ali, Sayed M Derayea. A new convenient methodology based on dihydropyridine derivative for selective fluorimetric analysis of baclofen: Application to spiked urine and content uniformity evaluation. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2021 Mar; 248(?):119165. doi: 10.1016/j.saa.2020.119165. [PMID: 33223435]
  • Nader Bakheet, Rabab Fouad, Abdel Meguid Kassem, Wessam Hussin, Mostafa El-Shazly. Persistent hiccup: A rare presentation of COVID-19. Respiratory investigation. 2021 Mar; 59(2):263-265. doi: 10.1016/j.resinv.2020.11.003. [PMID: 33309013]
  • Mohamed Ibrahim, Youssef W Naguib, Hatem A Sarhan, Hamdy Abdelkader. Preformulation-Assisted Design and Characterization of Modified Release Gastroretentive Floating Extrudates Towards Improved Bioavailability and Minimized Side Effects of Baclofen. Journal of pharmaceutical sciences. 2021 03; 110(3):1227-1239. doi: 10.1016/j.xphs.2020.10.025. [PMID: 33069710]
  • Vincent R Lee, Rachel M Shively, Michael K Connolly, Robert S Hoffman, Joshua Nogar. Removal of baclofen with hemodialysis is negligible compared to intact kidney excretion in a pediatric overdose: a case report. Clinical toxicology (Philadelphia, Pa.). 2021 Mar; 59(3):231-234. doi: 10.1080/15563650.2020.1795188. [PMID: 32734785]
  • Victor Echeverry-Alzate, Jérôme Jeanblanc, Pierre Sauton, Vanessa Bloch, Laurence Labat, Marion Soichot, Florence Vorspan, Mickael Naassila. Is R(+)-Baclofen the best option for the future of Baclofen in alcohol dependence pharmacotherapy? Insights from the preclinical side. Addiction biology. 2021 03; 26(2):e12892. doi: 10.1111/adb.12892. [PMID: 32146727]
  • Mehdi Farokhnia, Sara L Deschaine, Armin Sadighi, Lisa A Farinelli, Mary R Lee, Fatemeh Akhlaghi, Lorenzo Leggio. A deeper insight into how GABA-B receptor agonism via baclofen may affect alcohol seeking and consumption: lessons learned from a human laboratory investigation. Molecular psychiatry. 2021 02; 26(2):545-555. doi: 10.1038/s41380-018-0287-y. [PMID: 30382188]
  • Mingheng Li, Yan Huang, Rongchun Chen, Ning Liu, Shibing Fang. Efficacy and safety of tolperisone versus baclofen among Chinese patients with spasticity associated with spinal cord injury: a non-randomized retrospective study. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas. 2021; 54(11):e11293. doi: 10.1590/1414-431x2021e11293. [PMID: 34495247]
  • Marion Brunet, Maxime Léger, Pierre-André Billat, Bénédicte Lelièvre, Nicolas Lerolle, David Boels, Gaël Le Roux. Baclofen self-poisoning: Is renal replacement therapy efficient in patient with normal kidney function?. Anaesthesia, critical care & pain medicine. 2020 12; 39(6):813-817. doi: 10.1016/j.accpm.2020.07.021. [PMID: 33068797]
  • G Drevin, M Briet, S Ghamrawi, F Beloncle, C Abbara. Baclofen overdose following recreational use in adolescents and young adults: A case report and review of the literature. Forensic science international. 2020 Nov; 316(?):110541. doi: 10.1016/j.forsciint.2020.110541. [PMID: 33096455]
  • Sayna Norouzi, Samira S Farouk, Matthew A Sparks. Back off baclofen when the kidneys don't work. Kidney international. 2020 10; 98(4):829-831. doi: 10.1016/j.kint.2020.05.026. [PMID: 32998812]
  • Kianna J Chauvin, Peter G Blake, Amit X Garg, Matthew A Weir, Lavanya Bathini, Stephanie N Dixon, Eric McArthur, Jessica M Sontrop, Louise Moist, Richard B Kim, Flory T Muanda. Baclofen has a risk of encephalopathy in older adults receiving dialysis. Kidney international. 2020 10; 98(4):979-988. doi: 10.1016/j.kint.2020.04.047. [PMID: 32450156]
  • Minseon Cheong, Jongmin Lee, Tae Yeon Lee, Soon Bae Kim. Prevalence and risk factors of baclofen neurotoxicity in patients with severely impaired renal function. Nefrologia. 2020 Sep; 40(5):543-551. doi: 10.1016/j.nefro.2020.03.004. [PMID: 32718544]
  • Dongqing Cui, Yanxia Liu, Liang Jin, Liping Hu, Lili Cao. A novel compound heterozygous mutation in the arginase-1 gene identified in a Chinese patient with argininemia: A case report. Medicine. 2020 Aug; 99(32):e21634. doi: 10.1097/md.0000000000021634. [PMID: 32769929]
  • Mohamed Ibrahim, Hatem A Sarhan, Youssef W Naguib, Hamdy Abdelkader. Design, characterization and in vivo evaluation of modified release baclofen floating coated beads. International journal of pharmaceutics. 2020 May; 582(?):119344. doi: 10.1016/j.ijpharm.2020.119344. [PMID: 32315750]
  • Justin Gold, Kevin Zhao, Mickey Abraham, Rosemary Behmer Hansen, Meeki Lad, Antonios Mammis. Encephalopathy of Unknown Origin in a Baclofen Patient: Case Report and Review of the Literature. World neurosurgery. 2020 Apr; 136(?):136-139. doi: 10.1016/j.wneu.2020.01.044. [PMID: 31954899]
  • Shahram Ala, Mina Alvandipour, Majid Saeedi, Mohaddeseh Mansourifar, Mahila Monajati, Afshin Shiva. Effect of Topical Baclofen 5\% on Post-Hemorrhoidectomy Pain: Randomized Double Blind Placebo-Controlled Clinical Trial. Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 2020 02; 24(2):405-410. doi: 10.1007/s11605-019-04147-7. [PMID: 30783957]
  • Qingfeng He, Yashpal S Chhonker, Matthew J McLaughlin, Daryl J Murry. Simultaneous Quantitation of S(+)- and R(-)-Baclofen and Its Metabolite in Human Plasma and Cerebrospinal Fluid using LC-APCI-MS/MS: An Application for Clinical Studies. Molecules (Basel, Switzerland). 2020 Jan; 25(2):. doi: 10.3390/molecules25020250. [PMID: 31936209]
  • Sruthi P Thomas, Christina K Hardesty, Kristin A Buxton, Andrew B Collins, Jessica Pruente, Kelly L D Pham, Jordan Sheriko, M Elise McClanahan, Didem Inanoglu, Rajashree Srinivasan, Laura Ridnour, Robert Cooper, Seema Khurana, The Pediatric Itb Network. Pediatric intrathecal baclofen management during the COVID-19 pandemic in the US and Canada. Journal of pediatric rehabilitation medicine. 2020 ; 13(3):379-384. doi: 10.3233/prm-200755. [PMID: 33164962]
  • Giovanni D'Orazio, Chiara Fanali, Alessandra Gentili, Franco Tagliaro, Salvatore Fanali. Nano-liquid chromatography for enantiomers separation of baclofen by using vancomycin silica stationary phase. Journal of chromatography. A. 2019 Nov; 1605(?):360358. doi: 10.1016/j.chroma.2019.07.012. [PMID: 31337499]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • C de Marcellus, S le Bot, X Decleves, F Baud, S Renolleau, M Oualha. Report of severe accidental baclofen intoxication in a healthy 4-year-old boy and review of the literature. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie. 2019 Nov; 26(8):475-478. doi: 10.1016/j.arcped.2019.10.003. [PMID: 31685412]
  • Thotalampatti Pachiyappan Jeyaselvasenthilkumar, Deiveegan Kunjithapatham, Sekar Chinnasamy, Mohamed Abith Ali. Baclofen-induced Coma and Respiratory Depression in a Patient with Cervical Spondylotic Myelopathy with Chronic Kidney Disease. Neurology India. 2019 Jul; 67(4):1120-1121. doi: 10.4103/0028-3886.266260. [PMID: 31512651]
  • Mickael Vourc'h, Eric Dailly, Yannick Hourmant, Ronan Bellouard, Pierre-Joachim Mahe, Guillaume Deslandes, Matthieu Grégoire, Karim Asehnoune. Pharmacokinetics and toxicity of high-dose baclofen in ICU patients. Progress in neuro-psychopharmacology & biological psychiatry. 2019 06; 92(?):450-456. doi: 10.1016/j.pnpbp.2019.02.016. [PMID: 30826461]
  • Paolo Nikolai Hao So, Maria Ruby Rose Quijano Castañeda, Anne Rolaine Velasco Morante, Raymond Villacorta Oliva. Muscle spasm-induced exothermia in dystonic cerebral palsy: uncommon and frequently misdiagnosed condition. BMJ case reports. 2019 Mar; 12(3):. doi: 10.1136/bcr-2018-227488. [PMID: 30837235]
  • Sriram Sriperumbuduri, Swapnil Hiremath. The case for cautious consumption: NSAIDs in chronic kidney disease. Current opinion in nephrology and hypertension. 2019 03; 28(2):163-170. doi: 10.1097/mnh.0000000000000473. [PMID: 30531470]
  • Tae Hwan Kim, Jürgen B Bulitta, Do-Hyung Kim, Soyoung Shin, Beom Soo Shin. Novel extended in vitro-in vivo correlation model for the development of extended-release formulations for baclofen: From formulation composition to in vivo pharmacokinetics. International journal of pharmaceutics. 2019 Feb; 556(?):276-286. doi: 10.1016/j.ijpharm.2018.12.007. [PMID: 30543888]
  • Olga Geisel, Rainer Hellweg, Klaus-Dieter Wernecke, Klaus Wiedemann, Christian A Müller. Total and acylated ghrelin plasma levels as potential long-term response markers in alcohol-dependent patients receiving high-dose of the GABA-B receptor agonist baclofen. Psychiatry research. 2019 02; 272(?):431-437. doi: 10.1016/j.psychres.2018.12.095. [PMID: 30611960]
  • Olga Geisel, Ludwig Schlemm, Rainer Hellweg, Klaus Wiedemann, Christian A Müller. Hypothalamic-Pituitary-Adrenocortical Axis Activity in Alcohol-Dependent Patients During Treatment with High-Dose Baclofen. Pharmacopsychiatry. 2019 Jan; 52(1):32-37. doi: 10.1055/s-0043-124189. [PMID: 29359279]
  • Angeline Bowman, Rita Ayyangar, Ian Gonzales, Joseph Hornyak. Intrathecal baclofen toxicity in a patient with acute kidney injury. Journal of pediatric rehabilitation medicine. 2019 ; 12(3):313-315. doi: 10.3233/prm-180598. [PMID: 31476182]
  • Emad Khazneh, Alaa Shamlawi, Kamel Jebrin, Zakaria Hamdan, Osama Sawalmeh. Single-dose baclofen-induced neurotoxicity in a patient with end stage renal disease: case report. BMC nephrology. 2018 12; 19(1):352. doi: 10.1186/s12882-018-1167-z. [PMID: 30537935]
  • Claudia V Turco, Jenin El-Sayes, Mitchell B Locke, Robert Chen, Steven Baker, Aimee J Nelson. Effects of lorazepam and baclofen on short- and long-latency afferent inhibition. The Journal of physiology. 2018 11; 596(21):5267-5280. doi: 10.1113/jp276710. [PMID: 30192388]
  • Rafael Arroyo González. A review of the effects of baclofen and of THC:CBD oromucosal spray on spasticity-related walking impairment in multiple sclerosis. Expert review of neurotherapeutics. 2018 10; 18(10):785-791. doi: 10.1080/14737175.2018.1510772. [PMID: 30235965]
  • Magali Chartier, Isabelle Malissin, Salma Tannous, Laurence Labat, Patricia Risède, Bruno Mégarbane, Lucie Chevillard. Baclofen-induced encephalopathy in overdose - Modeling of the electroencephalographic effect/concentration relationships and contribution of tolerance in the rat. Progress in neuro-psychopharmacology & biological psychiatry. 2018 08; 86(?):131-139. doi: 10.1016/j.pnpbp.2018.05.016. [PMID: 29782961]
  • Magali Chartier, Salma Tannous, Nadia Benturquia, Laurence Labat, Rafael Reis, Patricia Risède, Lucie Chevillard, Bruno Mégarbane. Baclofen-Induced Neuro-Respiratory Toxicity in the Rat: Contribution of Tolerance and Characterization of Withdrawal Syndrome. Toxicological sciences : an official journal of the Society of Toxicology. 2018 07; 164(1):153-165. doi: 10.1093/toxsci/kfy073. [PMID: 29945230]
  • Majid Ghareghani, Kazem Zibara, Hossein Sadeghi, Naser Farhadi. Spasticity Treatment Ameliorates the Efficacy of Melatonin Therapy in Experimental Autoimmune Encephalomyelitis (EAE) Mouse Model of Multiple Sclerosis. Cellular and molecular neurobiology. 2018 Jul; 38(5):1145-1151. doi: 10.1007/s10571-018-0580-y. [PMID: 29497878]
  • Nurul H M Yusoff, Sharif M Mansor, Christian P Müller, Zurina Hassan. Baclofen blocks the acquisition and expression of mitragynine-induced conditioned place preference in rats. Behavioural brain research. 2018 06; 345(?):65-71. doi: 10.1016/j.bbr.2018.02.039. [PMID: 29499286]
  • S Y Issa, E M Hafez, A S El-Banna, S M Abdel Rahman, M K AlMazroua, M A El-Hamd. Baclofen systemic toxicity: Experimental histopathological and biochemical study. Human & experimental toxicology. 2018 Apr; 37(4):431-441. doi: 10.1177/0960327117712369. [PMID: 28565970]
  • Lucie Chevillard, Naomi Sabo, Michel Tod, Laurence Labat, Céline Chasport, Céline Chevaleyre, Florence Thibaut, Jérôme Barré, Julien Azuar, Franck Questel, Florence Vorspan, Vanessa Bloch, Frank Bellivier, Bernard Granger, Camille Barrault, Xavier Declèves. Population pharmacokinetics of oral baclofen at steady-state in alcoholic-dependent adult patients. Fundamental & clinical pharmacology. 2018 Apr; 32(2):239-248. doi: 10.1111/fcp.12330. [PMID: 29091319]
  • Abbas Ostovan, Mehrorang Ghaedi, Maryam Arabi. Fabrication of water-compatible superparamagnetic molecularly imprinted biopolymer for clean separation of baclofen from bio-fluid samples: A mild and green approach. Talanta. 2018 Mar; 179(?):760-768. doi: 10.1016/j.talanta.2017.12.017. [PMID: 29310305]
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