L-Ornithine (BioDeep_00000001400)

 

Secondary id: BioDeep_00000413278

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite Chemicals and Drugs


代谢物信息卡片


(2S)-2,5-diaminopentanoic acid

化学式: C5H12N2O2 (132.0899)
中文名称: 鸟氨酸, L-鸟氨酸, 鳥氨酸
谱图信息: 最多检出来源 Homo sapiens(blood) 19.51%

Reviewed

Last reviewed on 2024-07-01.

Cite this Page

L-Ornithine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/l-ornithine (retrieved 2024-12-26) (BioDeep RN: BioDeep_00000001400). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C(CC(C(=O)O)N)CN
InChI: InChI=1S/C5H12N2O2/c6-3-1-2-4(7)5(8)9/h4H,1-3,6-7H2,(H,8,9)/t4-/m0/s1

描述信息

Ornithine, also known as (S)-2,5-diaminopentanoic acid or ornithine, (L)-isomer, is a member of the class of compounds known as L-alpha-amino acids. L-alpha-amino acids are alpha amino acids which have the L-configuration of the alpha-carbon atom. Ornithine is soluble (in water) and a moderately acidic compound (based on its pKa). Ornithine can be found in a number of food items such as pine nut, lingonberry, turnip, and cassava, which makes ornithine a potential biomarker for the consumption of these food products. Ornithine can be found primarily in most biofluids, including urine, cerebrospinal fluid (CSF), feces, and saliva, as well as throughout most human tissues. Ornithine exists in all living species, ranging from bacteria to humans. In humans, ornithine is involved in few metabolic pathways, which include arginine and proline metabolism, glycine and serine metabolism, spermidine and spermine biosynthesis, and urea cycle. Ornithine is also involved in several metabolic disorders, some of which include ornithine transcarbamylase deficiency (OTC deficiency), prolidase deficiency (PD), citrullinemia type I, and arginine: glycine amidinotransferase deficiency (AGAT deficiency). Moreover, ornithine is found to be associated with cystinuria, alzheimers disease, leukemia, and uremia. Ornithine is a non-carcinogenic (not listed by IARC) potentially toxic compound. Ornithine is a drug which is used for nutritional supplementation, also for treating dietary shortage or imbalance. it has been claimed that ornithine improves athletic performance, has anabolic effects, has wound-healing effects, and is immuno-enhancing. Ornithine is a non-proteinogenic amino acid that plays a role in the urea cycle. Ornithine is abnormally accumulated in the body in ornithine transcarbamylase deficiency. The radical is ornithyl . L-Ornithine is metabolised to L-arginine. L-arginine stimulates the pituitary release of growth hormone. Burns or other injuries affect the state of L-arginine in tissues throughout the body. As De novo synthesis of L-arginine during these conditions is usually not sufficient for normal immune function, nor for normal protein synthesis, L-ornithine may have immunomodulatory and wound-healing activities under these conditions (by virtue of its metabolism to L-arginine) (DrugBank). Chronically high levels of ornithine are associated with at least 9 inborn errors of metabolism including: Cystathionine Beta-Synthase Deficiency, Hyperornithinemia with gyrate atrophy, Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome, Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome, Hyperprolinemia Type II, Lysinuric Protein Intolerance, Ornithine Aminotransferase Deficiency, Ornithine Transcarbamylase Deficiency and Prolinemia Type II (T3DB).
Ornithine or L-ornithine, also known as (S)-2,5-diaminopentanoic acid is a member of the class of compounds known as L-alpha-amino acids. L-alpha-amino acids are alpha amino acids which have the L-configuration of the alpha-carbon atom. L-ornithine is soluble (in water) and a moderately basic compound. Ornithine is a non-proteinogenic amino acid that plays a role in the urea cycle. It is considered to be a non-essential amino acid. A non-essential amino acid is an amino acid that can be synthesized from central metabolic pathway intermediates in humans and is not required in the diet. L-Ornithine is one of the products of the action of the enzyme arginase on L-arginine, creating urea. Therefore, ornithine is a central part of the urea cycle, which allows for the disposal of excess nitrogen. Outside the human body, L-ornithine is abundant in a number of food items such as wild rice, brazil nuts, common oregano, and common grapes. L-ornithine can be found throughout most human tissues; and in most biofluids, some of which include blood, urine, cerebrospinal fluid (CSF), sweat, saliva, and feces. L-ornithine exists in all living species, from bacteria to plants to humans. L-Ornithine is also a precursor of citrulline and arginine. In order for ornithine that is produced in the cytosol to be converted to citrulline, it must first cross the inner mitochondrial membrane into the mitochondrial matrix where it is carbamylated by the enzyme known as ornithine transcarbamylase. This transfer is mediated by the mitochondrial ornithine transporter (SLC25A15; AF112968; ORNT1). Mutations in the mitochondrial ornithine transporter result in hyperammonemia, hyperornithinemia, homocitrullinuria (HHH) syndrome, a disorder of the urea cycle (PMID: 16256388). The pathophysiology of the disease may involve diminished ornithine transport into mitochondria, resulting in ornithine accumulation in the cytoplasm and reduced ability to clear carbamoyl phosphate and ammonia loads (OMIM 838970). In humans, L-ornithine is involved in a number of other metabolic disorders, some of which include, ornithine transcarbamylase deficiency (OTC deficiency), argininemia, and guanidinoacetate methyltransferase deficiency (GAMT deficiency). Ornithine is abnormally accumulated in the body in ornithine transcarbamylase deficiency. Moreover, Ornithine is found to be associated with cystinuria, hyperdibasic aminoaciduria I, and lysinuric protein intolerance, which are inborn errors of metabolism. It has been claimed that ornithine improves athletic performance, has anabolic effects, has wound-healing effects, and is immuno-enhancing.

L-Ornithine. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=70-26-8 (retrieved 2024-07-01) (CAS RN: 70-26-8). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
L-Ornithine ((S)-2,5-Diaminopentanoic acid) is a non-proteinogenic amino acid, is mainly used in urea cycle removing excess nitrogen in vivo. L-Ornithine shows nephroprotective[1][2].
L-Ornithine ((S)-2,5-Diaminopentanoic acid) is a non-proteinogenic amino acid, is mainly used in urea cycle removing excess nitrogen in vivo. L-Ornithine shows nephroprotective[1][2].

同义名列表

39 个代谢物同义名

Ornithine monohydrochloride, (DL)-isomer; Ornithine monohydrochloride, (D)-isomer; Ornithine monohydrobromide, (L)-isomer; Ornithine phosphate (1:1), (L)-isomer; Ornithine dihydrochloride, (L)-isomer; Ornithine hydrochloride, (DL)-isomer; Ornithine hydrochloride, (L)-isomer; (S)-alpha,delta-Diaminovaleric acid; Ornithine sulfate (1:1), (L)-isomer; Ornithine hydrochloride, (D)-isomer; Ornithine monoacetate, (L)-isomer; (S)-alpha,delta-Diaminovalerate; (S)-a,delta-Diaminovaleric acid; (2S)-2,5-diaminopentanoic acid; (S)-2,5-Diaminopentanoic acid; L-Ornithine monohydrochloride; (S)-a,Δ-diaminovaleric acid; (S)-Α,δ-diaminovaleric acid; (S)-2,5-Diaminovaleric acid; (S)-a,D-Diaminovaleric acid; (S)-a,delta-Diaminovalerate; 2,5-Diaminopentanoic acid; 2,5 Diaminopentanoic acid; (S)-2,5-Diaminopentanoate; (S)-a,Δ-diaminovalerate; (S)-a,D-Diaminovalerate; (S)-Α,δ-diaminovalerate; (S)-2,5-Diaminovalerate; Ornithine, (DL)-isomer; Ornithine, (L)-isomer; Ornithine, (D)-isomer; 5-Amino-L-norvaline; (+)-S-Ornithine; L-(-)-Ornithine; polyornithine; (S)-Ornithine; L-Ornithine; Ornithine; Ornithine



数据库引用编号

45 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(1)

BioCyc(10)

PlantCyc(0)

代谢反应

767 个相关的代谢反应过程信息。

Reactome(30)

BioCyc(21)

WikiPathways(1)

Plant Reactome(640)

INOH(4)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(71)

PharmGKB(0)

140 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ARG1, ARG2, ASS1, AZIN2, CAT, GLUL, HDC, NOS2, OAT, OAZ3, SLC9A1
Mitochondrion membrane 1 SLC25A15
Nucleus 6 ARG1, AZIN2, GLUL, HDC, NOS2, OAZ3
cytosol 9 AMD1, ARG1, ASS1, AZIN2, CAT, GLUL, HDC, NOS2, OAZ3
dendrite 1 AZIN2
trans-Golgi network 1 AZIN2
nucleoplasm 6 ASS1, NOS2, OAT, OAZ3, PRODH, SLC9A1
Cell membrane 3 GLUL, SLC9A1, TNF
Lipid-anchor 1 GLUL
lamellipodium 1 SLC9A1
Cytoplasmic granule 1 ARG1
Multi-pass membrane protein 2 SLC25A15, SLC9A1
cell surface 2 SLC9A1, TNF
Golgi membrane 1 INS
mitochondrial inner membrane 4 GATM, OTC, PRODH, SLC25A15
neuronal cell body 1 TNF
Cytoplasm, cytosol 3 ASS1, GLUL, NOS2
plasma membrane 5 GCG, GLUL, NOS2, SLC9A1, TNF
Membrane 5 AZIN2, CAT, HDC, SLC25A15, SLC9A1
apical plasma membrane 1 SLC9A1
axon 1 AZIN2
basolateral plasma membrane 1 SLC9A1
extracellular exosome 5 ASS1, CAT, GATM, GLUL, SLC9A1
endoplasmic reticulum 1 GLUL
extracellular space 4 ARG1, GCG, INS, TNF
perinuclear region of cytoplasm 3 AZIN2, NOS2, SLC9A1
intercalated disc 1 SLC9A1
mitochondrion 11 ARG2, AZIN2, CAT, GATM, GLUL, OAT, OTC, PRODH, PYCR1, SLC25A15, SLC9A1
protein-containing complex 1 CAT
intracellular membrane-bounded organelle 2 CAT, PRODH
Secreted 2 GCG, INS
extracellular region 5 ARG1, CAT, GCG, INS, TNF
mitochondrial outer membrane 1 ASS1
Mitochondrion matrix 2 OAT, OTC
mitochondrial matrix 6 ARG2, CAT, OAT, OTC, PRODH, PYCR1
external side of plasma membrane 1 TNF
T-tubule 1 SLC9A1
perikaryon 2 ASS1, AZIN2
cytoplasmic vesicle 1 AZIN2
Cytoplasm, P-body 1 NOS2
P-body 1 NOS2
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Cytoplasm, perinuclear region 1 NOS2
Mitochondrion inner membrane 2 GATM, SLC25A15
Membrane raft 2 SLC9A1, TNF
focal adhesion 2 CAT, SLC9A1
cis-Golgi network 1 AZIN2
Peroxisome 2 CAT, NOS2
Peroxisome matrix 1 CAT
peroxisomal matrix 2 CAT, NOS2
peroxisomal membrane 1 CAT
mitochondrial intermembrane space 1 GATM
phagocytic cup 1 TNF
blood microparticle 1 OAZ3
Basolateral cell membrane 1 SLC9A1
endosome lumen 1 INS
cell body fiber 1 ASS1
cell body 1 GLUL
Microsome 1 GLUL
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 3 CAT, GCG, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 GCG, INS
specific granule lumen 1 ARG1
transport vesicle 2 AZIN2, INS
azurophil granule lumen 1 ARG1
Endoplasmic reticulum-Golgi intermediate compartment membrane 2 AZIN2, INS
endoplasmic reticulum-Golgi intermediate compartment 1 AZIN2
Golgi apparatus, cis-Golgi network 1 AZIN2
glial cell projection 1 GLUL
[Glucagon-like peptide 1]: Secreted 1 GCG
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
cortical cytoskeleton 1 NOS2
catalase complex 1 CAT
cation-transporting ATPase complex 1 SLC9A1
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF
granular vesicle 1 AZIN2


文献列表

  • Bayu Hadi Permana, Paitip Thiravetyan, Chairat Treesubsuntorn. Exogenous of different elicitors: proline and ornithine on Sansevieria trifasciata under particulate matter (PM) and volatile organic compounds (VOC). Environmental science and pollution research international. 2024 May; 31(23):34028-34037. doi: 10.1007/s11356-024-33513-5. [PMID: 38693456]
  • Leidy Patricia Bedoya-Pérez, Alejandro Aguilar-Vera, Mishael Sánchez-Pérez, José Utrilla, Christian Sohlenkamp. Enhancing Escherichia coli abiotic stress resistance through ornithine lipid formation. Applied microbiology and biotechnology. 2024 Apr; 108(1):288. doi: 10.1007/s00253-024-13130-5. [PMID: 38587638]
  • Liping Qu, Xiao Ma, Feifei Wang. The roles of gut microbiome and metabolites associated with skin photoaging in mice by intestinal flora sequencing and metabolomics. Life sciences. 2024 Feb; ?(?):122487. doi: 10.1016/j.lfs.2024.122487. [PMID: 38316265]
  • Wenbin Xu, Ren Mu, Tuya Gegen, Jiaxiang Luo, Yang Xiao, Shunnian Ou, Qi Wu, Yongsong Zuo, Zhi Chen, Fangwei Li. Comparative analysis of hepatic transcriptomes and metabolomes of Changshun green-shell laying hens based on different green eggshell color intensities. Poultry science. 2024 Jan; 103(1):103220. doi: 10.1016/j.psj.2023.103220. [PMID: 37980748]
  • Yao Zheng, Cécile Cabassa-Hourton, Holger Eubel, Guillaume Chevreux, Laurent Lignieres, Emilie Crilat, Hans-Peter Braun, Sandrine Lebreton, Arnould Savouré. Pyrroline-5-carboxylate metabolism protein complex detected in Arabidopsis thaliana leaf mitochondria. Journal of experimental botany. 2023 Oct; ?(?):. doi: 10.1093/jxb/erad406. [PMID: 37843921]
  • Jinxi Yang, Na Shi, Shisheng Wang, Manjiangcuo Wang, Yan Huang, Yiqin Wang, Ge Liang, Juqin Yang, Juan Rong, Yun Ma, Lan Li, Ping Zhu, Chenxia Han, Tao Jin, Hao Yang, Wei Huang, Daniel Raftery, Qing Xia, Dan Du. Multi-dimensional metabolomic profiling reveals dysregulated ornithine metabolism hallmarks associated with a severe acute pancreatitis phenotype. Translational research : the journal of laboratory and clinical medicine. 2023 Aug; ?(?):. doi: 10.1016/j.trsl.2023.08.003. [PMID: 37619665]
  • Wei Yan, Shuting Yuan, Yazhou Zu, Zhenyi Chang, Yiqi Li, Zhufeng Chen, Gang Xie, Lei Chen, Changqing Lu, Xing Wang Deng, Chengwei Yang, Chunjue Xu, Xiaoyan Tang. Ornithine δ-aminotransferase OsOAT is critical for male fertility and cold tolerance during rice plant development. The Plant journal : for cell and molecular biology. 2023 Jun; 114(6):1301-1318. doi: 10.1111/tpj.16194. [PMID: 36932862]
  • Yao Zheng, Cécile Cabassa-Hourton, Séverine Planchais, Emilie Crilat, Gilles Clément, Matthieu Dacher, Nina Durand, Marianne Bordenave-Jacquemin, Anne Guivarc'h, Corentin Dourmap, Pierre Carol, Sandrine Lebreton, Arnould Savouré. Pyrroline-5-carboxylate dehydrogenase is an essential enzyme for proline dehydrogenase function during dark-induced senescence in Arabidopsis thaliana. Plant, cell & environment. 2023 03; 46(3):901-917. doi: 10.1111/pce.14529. [PMID: 36583533]
  • Yang Liu, Andrew J Wilson, Jiatong Han, Alisa Hui, Lucy O'Sullivan, Tao Huan, Cara H Haney. Amino Acid Availability Determines Plant Immune Homeostasis in the Rhizosphere Microbiome. mBio. 2023 Feb; ?(?):e0342422. doi: 10.1128/mbio.03424-22. [PMID: 36786577]
  • Jakub Bělíček, Eva Ľuptáková, David Kopečný, Jan Frömmel, Armelle Vigouroux, Sanja Ćavar Zeljković, Franjo Jagic, Pierre Briozzo, David Jaroslav Kopečný, Petr Tarkowski, Jaroslav Nisler, Nuria De Diego, Solange Moréra, Martina Kopečná. Biochemical and structural basis of polyamine, lysine and ornithine acetylation catalyzed by spermine/spermidine N-acetyl transferase in moss and maize. The Plant journal : for cell and molecular biology. 2023 Feb; ?(?):. doi: 10.1111/tpj.16148. [PMID: 36786691]
  • Xiangjuan Yan, Fei Zhao, Guosheng Wang, Zhen Wang, Mingxi Zhou, Limin Zhang, Guoxiang Wang, Yanshan Chen. Metabolomic Analysis of Microcystis aeruginosa After Exposure to the Algicide L-Lysine. Bulletin of environmental contamination and toxicology. 2022 Dec; 110(1):12. doi: 10.1007/s00128-022-03658-5. [PMID: 36512146]
  • Yang Liu, Lei Chen, Lei Liu, Shan-Shan Zhao, Jun-Qiao You, Xin-Jie Zhao, Hui-Xin Liu, Guo-Wang Xu, De-Liang Wen. Interplay between dietary intake, gut microbiota, and metabolic profile in obese adolescents: Sex-dependent differential patterns. Clinical nutrition (Edinburgh, Scotland). 2022 12; 41(12):2706-2719. doi: 10.1016/j.clnu.2022.10.009. [PMID: 36351362]
  • Chang Liu, Wenhao Jiang, Fangwei Yang, Yuliang Cheng, Yahui Guo, Weirong Yao, Yong Zhao, He Qian. The combination of microbiome and metabolome to analyze the cross-cooperation mechanism of Echinacea purpurea polysaccharide with the gut microbiota in vitro and in vivo. Food & function. 2022 Oct; 13(19):10069-10082. doi: 10.1039/d2fo02336a. [PMID: 36093868]
  • Robert A Freudenberg, Luisa Wittemeier, Alexander Einhaus, Thomas Baier, Olaf Kruse. Advanced pathway engineering for phototrophic putrescine production. Plant biotechnology journal. 2022 10; 20(10):1968-1982. doi: 10.1111/pbi.13879. [PMID: 35748533]
  • Rhiannon Lyon, Rebekah A Jones, Holly Shropshire, Isabel Aberdeen, David J Scanlan, Andrew Millard, Yin Chen. Membrane lipid renovation in Pseudomonas aeruginosa - implications for phage therapy?. Environmental microbiology. 2022 10; 24(10):4533-4546. doi: 10.1111/1462-2920.16136. [PMID: 35837865]
  • Qing Zhang, Meixia Liang, Ruoxuan Song, Zhizhong Song, Hao Song, Xuqiang Qiao. Brassinosteroids enhance resistance to manganese toxicity in Malus robusta Rehd. via modulating polyamines profile. Journal of plant physiology. 2022 Oct; 277(?):153808. doi: 10.1016/j.jplph.2022.153808. [PMID: 36088781]
  • Dhara Patel, Tae Jin Lee, Sandeep Kumar, Sagar Vyavahare, Alison Worth, William D Hill, Mark Hamrick, Carlos M Isales, Rahul S Shinde, Sadanand Fulzele. Alterations in bone metabolites with age in C57BL/6 mice model. Biogerontology. 2022 10; 23(5):629-640. doi: 10.1007/s10522-022-09986-7. [PMID: 36056226]
  • Tetiana Mukhina, Georg Pabst, Jean-Marie Ruysschaert, Gerald Brezesinski, Emanuel Schneck. pH-Dependent physicochemical properties of ornithine lipid in mono- and bilayers. Physical chemistry chemical physics : PCCP. 2022 Sep; 24(37):22778-22791. doi: 10.1039/d2cp01045c. [PMID: 36111816]
  • Marina Urra, Javier Buezo, Beatriz Royo, Alfonso Cornejo, Pedro López-Gómez, Daniel Cerdán, Raquel Esteban, Víctor Martínez-Merino, Yolanda Gogorcena, Paraskevi Tavladoraki, Jose Fernando Moran. The importance of the urea cycle and its relationships to polyamine metabolism during ammonium stress in Medicago truncatula. Journal of experimental botany. 2022 09; 73(16):5581-5595. doi: 10.1093/jxb/erac235. [PMID: 35608836]
  • Martin H Rau, Paula Gaspar, Maiken Lund Jensen, Asger Geppel, Ana Rute Neves, Ahmad A Zeidan. Genome-Scale Metabolic Modeling Combined with Transcriptome Profiling Provides Mechanistic Understanding of Streptococcus thermophilus CH8 Metabolism. Applied and environmental microbiology. 2022 08; 88(16):e0078022. doi: 10.1128/aem.00780-22. [PMID: 35924931]
  • Jonathan D Reiss, Alan L Chang, Jonathan A Mayo, Katherine Bianco, Henry C Lee, David K Stevenson, Gary M Shaw, Nima Aghaeepour, Karl G Sylvester. Newborn screen metabolic panels reflect the impact of common disorders of pregnancy. Pediatric research. 2022 08; 92(2):490-497. doi: 10.1038/s41390-021-01753-7. [PMID: 34671094]
  • Daniela Liebsch, Marta Juvany, Zhonghai Li, Hou-Ling Wang, Agnieszka Ziolkowska, Daria Chrobok, Clément Boussardon, Xing Wen, Simon R Law, Helena Janečková, Bastiaan Brouwer, Pernilla Lindén, Nicolas Delhomme, Hans Stenlund, Thomas Moritz, Per Gardeström, Hongwei Guo, Olivier Keech. Metabolic control of arginine and ornithine levels paces the progression of leaf senescence. Plant physiology. 2022 08; 189(4):1943-1960. doi: 10.1093/plphys/kiac244. [PMID: 35604104]
  • Alexandre de Fátima Cobre, Monica Surek, Dile Pontarolo Stremel, Mariana Millan Fachi, Helena Hiemisch Lobo Borba, Fernanda Stumpf Tonin, Roberto Pontarolo. Diagnosis and prognosis of COVID-19 employing analysis of patients' plasma and serum via LC-MS and machine learning. Computers in biology and medicine. 2022 Jul; 146(?):105659. doi: 10.1016/j.compbiomed.2022.105659. [PMID: 35751188]
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  • Xiaofeng Wang, Regis A Vilchez. Population Pharmacokinetic Analysis to Assist Dose Selection of the L-Ornithine Salt of Phenylacetic Acid. Clinical pharmacokinetics. 2022 04; 61(4):515-526. doi: 10.1007/s40262-021-01075-1. [PMID: 34786649]
  • Claudia Sikorski, Sandi Azab, Russell J de Souza, Meera Shanmuganathan, Dipika Desai, Koon Teo, Stephanie A Atkinson, Katherine Morrison, Milan Gupta, Philip Britz-McKibbin, Sonia S Anand. Serum metabolomic signatures of gestational diabetes in South Asian and white European women. BMJ open diabetes research & care. 2022 04; 10(2):. doi: 10.1136/bmjdrc-2021-002733. [PMID: 35450870]
  • Yumi Hoshino, Minori Kodaira, Atsuhiro Matsuno, Tomoki Kaneko, Tetsuhiro Fukuyama, Kyoko Takano, Masahide Yazaki, Yoshiki Sekijima. Reversible Leukoencephalopathy in a Man with Childhood-onset Hyperornithinemia-Hyperammonemia-Homocitrullinuria Syndrome. Internal medicine (Tokyo, Japan). 2022 Feb; 61(4):553-557. doi: 10.2169/internalmedicine.7843-21. [PMID: 34433721]
  • Armand M A Linkens, Alfons J H M Houben, Abraham A Kroon, Miranda T Schram, Tos T J M Berendschot, Carroll A B Webers, Marleen van Greevenbroek, Ronald M A Henry, Bastiaan de Galan, Coen D A Stehouwer, Simone J M P Eussen, Casper G Schalkwijk. Habitual intake of dietary advanced glycation end products is not associated with generalized microvascular function-the Maastricht Study. The American journal of clinical nutrition. 2022 02; 115(2):444-455. doi: 10.1093/ajcn/nqab302. [PMID: 34581759]
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  • Kuo-Hsuan Chang, Mei-Ling Cheng, Hsiang-Yu Tang, Cheng-Yu Huang, Hsiu-Chuan Wu, Chiung-Mei Chen. Alterations of Sphingolipid and Phospholipid Pathways and Ornithine Level in the Plasma as Biomarkers of Parkinson's Disease. Cells. 2022 01; 11(3):. doi: 10.3390/cells11030395. [PMID: 35159203]
  • Ikuho Ban, Hikari Sugawa, Ryoji Nagai. Protein Modification with Ribose Generates Nδ-(5-hydro-5-methyl-4-imidazolone-2-yl)-ornithine. International journal of molecular sciences. 2022 01; 23(3):. doi: 10.3390/ijms23031224. [PMID: 35163152]
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