L-Homoserine (BioDeep_00000001371)
Secondary id: BioDeep_00000400300
natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite
代谢物信息卡片
(2S)-2-Amino-4-hydroxybutanoic acid
化学式: C4H9NO3 (119.0582404)
中文名称: DL-高丝氨酸, L-高丝氨酸, D-高丝氨酸, 高丝氨酸
谱图信息:
最多检出来源 Homo sapiens(blood) 0.07%
Reviewed
Last reviewed on 2024-07-02.
Cite this Page
L-Homoserine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/l-homoserine (retrieved
2024-09-17) (BioDeep RN: BioDeep_00000001371). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: C(CO)C(C(=O)O)N
InChI: InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8)
描述信息
L-homoserine, also known as 2-amino-4-hydroxybutanoic acid or isothreonine, is a member of the class of compounds known as L-alpha-amino acids. L-alpha-amino acids are alpha amino acids which have the L-configuration of the alpha-carbon atom. L-homoserine is soluble (in water) and a moderately acidic compound (based on its pKa). L-homoserine can be found in common pea, which makes L-homoserine a potential biomarker for the consumption of this food product. L-homoserine can be found primarily in blood, feces, and urine, as well as in human prostate tissue. L-homoserine exists in all living species, ranging from bacteria to humans. In humans, L-homoserine is involved in the methionine metabolism. L-homoserine is also involved in several metabolic disorders, some of which include glycine n-methyltransferase deficiency, hypermethioninemia, cystathionine beta-synthase deficiency, and methylenetetrahydrofolate reductase deficiency (MTHFRD). Homoserine (also called isothreonine) is an α-amino acid with the chemical formula HO2CCH(NH2)CH2CH2OH. L-Homoserine is not one of the common amino acids encoded by DNA. It differs from the proteinogenic amino acid serine by insertion of an additional -CH2- unit into the backbone. Homoserine, or its lactone form, is the product of a cyanogen bromide cleavage of a peptide by degradation of methionine .
Homoserine is a more reactive variant of the amino acid serine. In this variant, the hydroxyl side chain contains an additional CH2 group which brings the hydroxyl group closer to its own carboxyl group, allowing it to chemically react to form a five-membered ring. This occurs at the point that amino acids normally join to their neighbours in a peptide bond. Homoserine is therefore unsuitable for forming proteins and has been eliminated from the repertoire of amino acids used by living things. Homoserine is the final product on the C-terminal end of the N-terminal fragment following a cyanogen bromide cleavage. (wikipedia). Homoserine is also a microbial metabolite.
L-Homoserine. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=672-15-1 (retrieved 2024-07-02) (CAS RN: 672-15-1). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
L-Homoserine is a non - protein amino acid, which is an important biosynthetic intermediate of threonine, methionine and lysine.
L-Homoserine is a non - protein amino acid, which is an important biosynthetic intermediate of threonine, methionine and lysine.
同义名列表
26 个代谢物同义名
(2S)-2-Amino-4-hydroxybutanoic acid; (S)-2-Amino-4-hydroxy-butanoic acid; (S)-2-Amino-4-hydroxybutanoic acid; 2-Amino-4-hydroxy-L-butyric acid; (S)-2-Amino-4-hydroxy-butanoate; (2S)-2-Amino-4-hydroxybutanoate; 2-Amino-4-hydroxybutanoic acid; 2-Amino-4-hydroxy-butyric acid; (S)-2-Amino-4-hydroxybutanoate; 2-Amino-4-hydroxybutyric acid; 2-Amino-4-hydroxy-L-butyrate; 2-Amino-4-hydroxy-butyrate; 2-Amino-4-hydroxybutanoate; 2-Amino-4-hydroxybutyrate; L-Isomer OF homoserine; L Isomer OF homoserine; Homoserine L-isomer; L-(-)-Homoserine; (S)-Homoserine; dl -homoserine; DL-Homoserine; L-Homoserine; D-Homoserine; L-Homoserine; Homoserine; Homoserine
数据库引用编号
42 个数据库交叉引用编号
- ChEBI: CHEBI:30653
- ChEBI: CHEBI:15699
- KEGG: C00263
- PubChem: 12647
- PubChem: 779
- HMDB: HMDB0000719
- Metlin: METLIN3713
- Metlin: METLIN288
- DrugBank: DB04193
- ChEMBL: CHEMBL11722
- Wikipedia: Homoserine
- MeSH: Homoserine
- MetaCyc: HOMO-SER
- KNApSAcK: C00001366
- foodb: FDB006683
- chemspider: 12126
- CAS: 672-15-1
- MoNA: KNA00143
- MoNA: KO003060
- MoNA: KNA00728
- MoNA: KNA00730
- MoNA: PS062803
- MoNA: KNA00555
- MoNA: KNA00729
- MoNA: KNA00142
- MoNA: KO003062
- MoNA: KNA00342
- MoNA: PR100726
- MoNA: KO003059
- MoNA: KNA00141
- MoNA: PS062801
- MoNA: KNA00341
- MoNA: KNA00554
- MoNA: KNA00340
- MoNA: KO003061
- MoNA: PS062802
- MoNA: PR100294
- PMhub: MS000000406
- PDB-CCD: HSE
- 3DMET: B01202
- NIKKAJI: J9.199E
- medchemexpress: HY-W002292
分类词条
相关代谢途径
Reactome(0)
BioCyc(7)
PlantCyc(0)
代谢反应
595 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(28)
- isoleucine biosynthesis I:
thr ⟶ 2-oxobutanoate + H+ + ammonia - methionine biosynthesis II:
H2O + L-cystathionine ⟶ H+ + L-homocysteine + ammonia + pyruvate - superpathway of sulfur amino acid biosynthesis (Saccharomyces cerevisiae):
H2O + L-cystathionine ⟶ H+ + L-homocysteine + ammonia + pyruvate - homocysteine biosynthesis:
O-acetyl-L-homoserine + hydrogen sulfide ⟶ H+ + L-homocysteine + acetate - threonine biosynthesis:
2-oxoglutarate + asp ⟶ glt + oxaloacetate - homoserine biosynthesis:
ATP + asp ⟶ ADP + H+ + L-aspartyl-4-phosphate - threonine biosynthesis from homoserine:
ATP + L-homoserine ⟶ ADP + H+ + O-phospho-L-homoserine - cysteine biosynthesis IV (fungi):
H2O + L-cystathionine ⟶ H+ + L-homocysteine + ammonia + pyruvate - canavanine biosynthesis:
L-homoserine + ammonia ⟶ H+ + L-canaline - threonine biosynthesis from homoserine:
H2O + O-phospho-L-homoserine ⟶ phosphate + thr - homoserine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - methionine biosynthesis:
H2O + L-cystathionine ⟶ H+ + L-homocysteine + ammonia + pyruvate - aspartate superpathway:
ATP + ammonia + nicotinate adenine dinucleotide ⟶ AMP + H+ + NAD+ + diphosphate - superpathway of lysine, threonine and methionine biosynthesis II:
H2O + L-cystathionine ⟶ H+ + L-homocysteine + ammonia + pyruvate - isoleucine biosynthesis I:
thr ⟶ 2-oxobutanoate + H+ + ammonia - superpathway of lysine, threonine and methionine biosynthesis I:
H2O + L-cystathionine ⟶ H+ + L-homocysteine + ammonia + pyruvate - threonine biosynthesis:
2-oxoglutarate + asp ⟶ glt + oxaloacetate - methionine biosynthesis II:
H2O + L-cystathionine ⟶ H+ + L-homocysteine + ammonia + pyruvate - methionine biosynthesis I:
H2O + L-cystathionine ⟶ H+ + L-homocysteine + ammonia + pyruvate - threonine biosynthesis from homoserine:
H2O + O-phospho-L-homoserine ⟶ phosphate + thr - homoserine biosynthesis:
L-aspartate-semialdehyde + NADP+ + phosphate ⟶ H+ + L-aspartyl-4-phosphate + NADPH - methionine biosynthesis I:
H2O + L-cystathionine ⟶ H+ + L-homocysteine + ammonia + pyruvate - homoserine biosynthesis:
ATP + asp ⟶ ADP + L-aspartyl-4-phosphate - aspartate superpathway:
H2O + L-cystathionine ⟶ H+ + L-homocysteine + ammonia + pyruvate - threonine biosynthesis from homoserine:
ATP + L-homoserine ⟶ ADP + H+ + O-phospho-L-homoserine - canavanine degradation:
H+ + L-canaline + NADPH ⟶ L-homoserine + NADP+ + ammonia - superpathway of lysine, threonine and methionine biosynthesis I:
H2O + L-cystathionine ⟶ H+ + L-homocysteine + ammonia + pyruvate - threonine biosynthesis:
2-oxoglutarate + asp ⟶ glt + oxaloacetate
WikiPathways(0)
Plant Reactome(531)
- Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Amino acid metabolism:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Amino acid biosynthesis:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homocysteine biosynthesis:
Ac-CoA + homoserine ⟶ CoA-SH + O-acetyl-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Metabolism and regulation:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Amino acid metabolism:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Amino acid biosynthesis:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Metabolism and regulation:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Amino acid metabolism:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Amino acid biosynthesis:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Metabolism and regulation:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Amino acid metabolism:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Amino acid biosynthesis:
L-Glu + imidazole acetol-phosphate ⟶ 2OG + L-histidinol-phosphate - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
ATP + L-Asp ⟶ ADP + L-aspartyl-4-phosphate - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Metabolism and regulation:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid metabolism:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Metabolism and regulation:
ATP + CoA + propionate ⟶ AMP + PPi + PROP-CoA - Amino acid metabolism:
ATP + CoA + propionate ⟶ AMP + PPi + PROP-CoA - Amino acid biosynthesis:
ATP + CoA + propionate ⟶ AMP + PPi + PROP-CoA - Canavanine biosynthesis:
ATP + L-Asp + O-ureidohomoserine ⟶ AMP + PPi + canavaninosuccinate - Homocysteine biosynthesis:
H2S + O-acetyl-L-homoserine ⟶ CH3COO- + LHCYS - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Metabolism and regulation:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid metabolism:
CoA + NAD + methylmalonate-semialdehyde ⟶ NADH + PROP-CoA + carbon dioxide - Amino acid biosynthesis:
FAD + PROP-CoA ⟶ FADH2 + acryloyl-CoA - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine - Homoserine biosynthesis:
H+ + L-aspartyl-4-phosphate + TPNH ⟶ L-aspartate-semialdehyde + Pi + TPN - Methionine biosynthesis II:
CYSTA + H2O ⟶ L-homocysteine + PYR + ammonia - Threonine biosynthesis from homoserine:
ATP + homoserine ⟶ ADP + O-phospho-L-homoserine
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(36)
- Cysteine Metabolism:
L-Cystathionine + Water ⟶ 2-Ketobutyric acid + Ammonium + L-Cysteine - Methionine Metabolism and Salvage:
2-Oxo-4-methylthiobutanoic acid + L-Phenylalanine ⟶ 2-Ketobutyric acid + L-Methionine - Methionine Metabolism:
L-Cystathionine + Water ⟶ 2-Ketobutyric acid + L-Cysteine - Cystathionine beta-Synthase Deficiency:
L-Cystathionine + Water ⟶ 2-Ketobutyric acid + L-Cysteine - Hypermethioninemia:
L-Cystathionine + Water ⟶ 2-Ketobutyric acid + L-Cysteine - S-Adenosylhomocysteine (SAH) Hydrolase Deficiency:
L-Cystathionine + Water ⟶ 2-Ketobutyric acid + L-Cysteine - Glycine N-Methyltransferase Deficiency:
L-Cystathionine + Water ⟶ 2-Ketobutyric acid + L-Cysteine - Methylenetetrahydrofolate Reductase Deficiency (MTHFRD):
L-Cystathionine + Water ⟶ 2-Ketobutyric acid + L-Cysteine - Methionine Adenosyltransferase Deficiency:
L-Cystathionine + Water ⟶ 2-Ketobutyric acid + L-Cysteine - Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type:
L-Cystathionine + Water ⟶ 2-Ketobutyric acid + L-Cysteine - Methionine Biosynthesis:
L-Cysteine + O-succinyl-L-homoserine ⟶ Hydrogen Ion + L-Cystathionine + Succinic acid - Threonine Biosynthesis:
L-Glutamic acid + Oxalacetic acid ⟶ L-Aspartic acid + Oxoglutaric acid - Secondary Metabolites: Threonine Biosynthesis from Aspartate:
O-Phosphohomoserine + Water ⟶ L-Threonine + Phosphate - Threonine Metabolism:
L-Threonine ⟶ Acetaldehyde + Glycine - Methionine Metabolism:
2-iminobutanoate + Hydrogen Ion + Water ⟶ 2-Ketobutyric acid + Ammonium - Threonine Metabolism:
2-iminobutanoate + Hydrogen Ion + Water ⟶ 2-Ketobutyric acid + Ammonium - Methionine Metabolism:
L-Cystathionine + Water ⟶ 2-Ketobutyric acid + L-Cysteine - Cystathionine beta-Synthase Deficiency:
L-Cystathionine + Water ⟶ 2-Ketobutyric acid + L-Cysteine - Glycine N-Methyltransferase Deficiency:
L-Cystathionine + Water ⟶ 2-Ketobutyric acid + L-Cysteine - Hypermethioninemia:
L-Cystathionine + Water ⟶ 2-Ketobutyric acid + L-Cysteine - Methionine Adenosyltransferase Deficiency:
L-Cystathionine + Water ⟶ 2-Ketobutyric acid + L-Cysteine - S-Adenosylhomocysteine (SAH) Hydrolase Deficiency:
L-Cystathionine + Water ⟶ 2-Ketobutyric acid + L-Cysteine - Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type:
L-Cystathionine + Water ⟶ 2-Ketobutyric acid + L-Cysteine - Methionine Metabolism:
L-Cystathionine + Water ⟶ 2-Ketobutyric acid + L-Cysteine - Methionine Metabolism:
L-Cystathionine + Water ⟶ 2-Ketobutyric acid + L-Cysteine - Methionine Metabolism:
L-Cystathionine + Water ⟶ 2-Ketobutyric acid + L-Cysteine - Methionine Metabolism:
L-Cystathionine + Water ⟶ 2-Ketobutyric acid + L-Cysteine - Cystathionine beta-Synthase Deficiency:
L-Cystathionine + Water ⟶ 2-Ketobutyric acid + L-Cysteine - Glycine N-Methyltransferase Deficiency:
L-Cystathionine + Water ⟶ 2-Ketobutyric acid + L-Cysteine - Hypermethioninemia:
L-Cystathionine + Water ⟶ 2-Ketobutyric acid + L-Cysteine - Methionine Adenosyltransferase Deficiency:
L-Cystathionine + Water ⟶ 2-Ketobutyric acid + L-Cysteine - S-Adenosylhomocysteine (SAH) Hydrolase Deficiency:
L-Cystathionine + Water ⟶ 2-Ketobutyric acid + L-Cysteine - Homocystinuria-Megaloblastic Anemia Due to Defect in Cobalamin Metabolism, cblG Complementation Type:
L-Cystathionine + Water ⟶ 2-Ketobutyric acid + L-Cysteine - Methionine Biosynthesis:
L-Cysteine + O-succinyl-L-homoserine ⟶ Hydrogen Ion + L-Cystathionine + Succinic acid - Threonine Biosynthesis:
L-Glutamic acid + Oxalacetic acid ⟶ L-Aspartic acid + Oxoglutaric acid - Secondary Metabolites: Threonine Biosynthesis from Aspartate:
O-Phosphohomoserine + Water ⟶ L-Threonine + Phosphate
PharmGKB(0)
2 个相关的物种来源信息
- 9606 Homo sapiens: -
- 569774 金线莲: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yaguang Zhao, Fenghua Zhang, Bede Mickan, Dan Wang. Inoculation of wheat with Bacillus sp. wp-6 altered amino acid and flavonoid metabolism and promoted plant growth.
Plant cell reports.
2023 Jan; 42(1):165-179. doi:
10.1007/s00299-022-02947-x. [PMID: 36348065] - Umang Dhaubhadel, Abiud E Portillo, Ondřej Horáček, Yu-Sheng Sung, Daniel W Armstrong. Unusual enantiomeric D,L-N-acyl homoserine lactones in Pectobacterium atrosepticum and Pseudomonas aeruginosa.
PloS one.
2023; 18(3):e0283657. doi:
10.1371/journal.pone.0283657. [PMID: 37000717] - Xiaozhen Liu, Qinmeng Liu, Sihuai Sun, Hengxi Sun, Yao Wang, Xihui Shen, Lei Zhang. Exploring AI-2-mediated interspecies communications within rumen microbial communities.
Microbiome.
2022 10; 10(1):167. doi:
10.1186/s40168-022-01367-z. [PMID: 36203182] - Rudi Hendra, Mariam N Salib, Tadeusz F Molinski. Spiroisoxazoline Inhibitors of Acetylcholinesterase from Pseudoceratina verrucosa. Quantitative Chiroptical Analysis of Configurational Heterogeneity, and Total Synthesis of (±)-Methyl Purpuroceratate C.
Journal of natural products.
2022 09; 85(9):2207-2216. doi:
10.1021/acs.jnatprod.2c00595. [PMID: 36095307] - Radhika Khera, Ahmad R Mehdipour, Jani R Bolla, Joerg Kahnt, Sonja Welsch, Ulrich Ermler, Cornelia Muenke, Carol V Robinson, Gerhard Hummer, Hao Xie, Hartmut Michel. Cryo-EM structures of pentameric autoinducer-2 exporter from Escherichia coli reveal its transport mechanism.
The EMBO journal.
2022 09; 41(18):e109990. doi:
10.15252/embj.2021109990. [PMID: 35698912] - Wei Cheng, Zhenyu Wang, Yi Xiong, Zhifeng Wu, Xiang Tan, Yapeng Yang, Hang Zhang, Xi Zhu, Hong Wei, Shiyu Tao. N-(3-oxododecanoyl)-homoserine lactone disrupts intestinal barrier and induces systemic inflammation through perturbing gut microbiome in mice.
The Science of the total environment.
2021 Jul; 778(?):146347. doi:
10.1016/j.scitotenv.2021.146347. [PMID: 34030388] - Qinqin Pu, Kai Guo, Ping Lin, Zhihan Wang, Shugang Qin, Pan Gao, Colin Combs, Nadeem Khan, Zhenwei Xia, Min Wu. Bitter receptor TAS2R138 facilitates lipid droplet degradation in neutrophils during Pseudomonas aeruginosa infection.
Signal transduction and targeted therapy.
2021 06; 6(1):210. doi:
10.1038/s41392-021-00602-7. [PMID: 34083514] - Sapir Ya'ar Bar, Shlomit Dor, Mayan Erov, Livnat Afriat-Jurnou. Identification and Characterization of a New Quorum-Quenching N-acyl Homoserine Lactonase in the Plant Pathogen Erwinia amylovora.
Journal of agricultural and food chemistry.
2021 May; 69(20):5652-5662. doi:
10.1021/acs.jafc.1c00366. [PMID: 33974427] - Charles Ar Cotton, Iria Bernhardsgrütter, Hai He, Simon Burgener, Luca Schulz, Nicole Paczia, Beau Dronsella, Alexander Erban, Stepan Toman, Marian Dempfle, Alberto De Maria, Joachim Kopka, Steffen N Lindner, Tobias J Erb, Arren Bar-Even. Underground isoleucine biosynthesis pathways in E. coli.
eLife.
2020 08; 9(?):. doi:
10.7554/elife.54207. [PMID: 32831171] - Qin Xiong, Di Liu, Huihui Zhang, Xiaoyan Dong, Guishan Zhang, Yunpeng Liu, Ruifu Zhang. Quorum sensing signal autoinducer-2 promotes root colonization of Bacillus velezensis SQR9 by affecting biofilm formation and motility.
Applied microbiology and biotechnology.
2020 Aug; 104(16):7177-7185. doi:
10.1007/s00253-020-10713-w. [PMID: 32621125] - Narendranath Bhokisham, Yi Liu, Adam D Brown, Gregory F Payne, James N Culver, William E Bentley. Transglutaminase-mediated assembly of multi-enzyme pathway onto TMV brush surfaces for synthesis of bacterial autoinducer-2.
Biofabrication.
2020 07; 12(4):045017. doi:
10.1088/1758-5090/ab9e7a. [PMID: 32559753] - Ajay Patel, Lillian Abdelmalek, Austin Thompson, Ishwarlal Jialal. Decreased homoserine levels in metabolic syndrome.
Diabetes & metabolic syndrome.
2020 Jul; 14(4):555-559. doi:
10.1016/j.dsx.2020.04.052. [PMID: 32413818] - Hai He, Rune Höper, Moritz Dodenhöft, Philippe Marlière, Arren Bar-Even. An optimized methanol assimilation pathway relying on promiscuous formaldehyde-condensing aldolases in E. coli.
Metabolic engineering.
2020 07; 60(?):1-13. doi:
10.1016/j.ymben.2020.03.002. [PMID: 32169542] - Tong Liu, Xiang Gu, Li-Xiang Li, Ming Li, Bing Li, Xiao Cui, Xiu-Li Zuo. Microbial and metabolomic profiles in correlation with depression and anxiety co-morbidities in diarrhoea-predominant IBS patients.
BMC microbiology.
2020 06; 20(1):168. doi:
10.1186/s12866-020-01841-4. [PMID: 32552668] - Eleanor F Vesty, Amy L Whitbread, Sarah Needs, Wesal Tanko, Kirsty Jones, Nigel Halliday, Fatemeh Ghaderiardakani, Xiaoguang Liu, Miguel Cámara, Juliet C Coates. Cross-kingdom signalling regulates spore germination in the moss Physcomitrella patens.
Scientific reports.
2020 02; 10(1):2614. doi:
10.1038/s41598-020-59467-5. [PMID: 32054953] - Tomohiro Morohoshi, Yuto Ogasawara, Xiaonan Xie, Hiroshi Hamamoto, Nobutaka Someya. Genetic and Biochemical Diversity for N-acylhomoserine Lactone Biosynthesis in the Plant Pathogen Pectobacterium carotovorum subsp. carotovorum.
Microbes and environments.
2019 Dec; 34(4):429-435. doi:
10.1264/jsme2.me19105. [PMID: 31666459] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - I Matityahu, I Godo, Y Hacham, R Amir. The level of threonine in tobacco seeds is limited by substrate availability, while the level of methionine is limited also by the activity of cystathionine γ-synthase.
Plant science : an international journal of experimental plant biology.
2019 Jun; 283(?):195-201. doi:
10.1016/j.plantsci.2019.02.020. [PMID: 31128689] - Yu V Zaitseva, V A Lipasova, V A Plyuta, O A Koksharova, I V Demidyuk, S V Kostrov, I A Khmel. Effect of inactivation of luxS gene on the properties of Serratia proteamaculans 94 strain.
Folia microbiologica.
2019 May; 64(3):265-272. doi:
10.1007/s12223-018-0657-5. [PMID: 30361877] - Fusheng Wang, Weizhong Li, Guanghuan Wang, Menglu Yu, Jun Zhong, Chenbin Xu, Danli Li, Yongcui Zhou. Gas chromatography-mass spectrometry based serum metabolic analysis for premature infants and the relationship with necrotizing enterocolitis: a cross-sectional study.
Italian journal of pediatrics.
2019 Apr; 45(1):54. doi:
10.1186/s13052-019-0646-6. [PMID: 31036043] - Zujie Yao, Zhuang Guo, Yuqian Wang, Wanxin Li, Yuying Fu, Yuexu Lin, Wenxiong Lin, Xiangmin Lin. Integrated Succinylome and Metabolome Profiling Reveals Crucial Role of S-Ribosylhomocysteine Lyase in Quorum Sensing and Metabolism of Aeromonas hydrophila.
Molecular & cellular proteomics : MCP.
2019 02; 18(2):200-215. doi:
10.1074/mcp.ra118.001035. [PMID: 30352804] - Dingka Song, Junchen Meng, Jie Cheng, Zheng Fan, Pengyu Chen, Hefei Ruan, Zhongyuan Tu, Ning Kang, Nan Li, Ying Xu, Xiaobo Wang, Fei Shu, Libing Mu, Tengfei Li, Wenran Ren, Xin Lin, Jun Zhu, Xiaohong Fang, Matthias W Amrein, Weihui Wu, Li-Tang Yan, Junhong Lü, Tie Xia, Yan Shi. Pseudomonas aeruginosa quorum-sensing metabolite induces host immune cell death through cell surface lipid domain dissolution.
Nature microbiology.
2019 01; 4(1):97-111. doi:
10.1038/s41564-018-0290-8. [PMID: 30510173] - Will Buswell, Roland E Schwarzenbacher, Estrella Luna, Matthew Sellwood, Beining Chen, Victor Flors, Pierre Pétriacq, Jurriaan Ton. Chemical priming of immunity without costs to plant growth.
The New phytologist.
2018 05; 218(3):1205-1216. doi:
10.1111/nph.15062. [PMID: 29465773] - Zhangjian Hu, Shujun Shao, Chenfei Zheng, Zenghui Sun, Junying Shi, Jingquan Yu, Zhenyu Qi, Kai Shi. Induction of systemic resistance in tomato against Botrytis cinerea by N-decanoyl-homoserine lactone via jasmonic acid signaling.
Planta.
2018 May; 247(5):1217-1227. doi:
10.1007/s00425-018-2860-7. [PMID: 29445868] - Loureen Dahli, Dana Atrahimovich, Jacob Vaya, Soliman Khatib. Lyso-DGTS lipid isolated from microalgae enhances PON1 activities in vitro and in vivo, increases PON1 penetration into macrophages and decreases cellular lipid accumulation.
BioFactors (Oxford, England).
2018 May; 44(3):299-310. doi:
10.1002/biof.1427. [PMID: 29659105] - Michael Rothballer, Jenny Uhl, Josie Kunze, Philippe Schmitt-Kopplin, Anton Hartmann. Detection of the Bacterial Quorum-Sensing Signaling Molecules N-Acyl-Homoserine Lactones (HSL) and N-Acyl-Homoserine (HS) with an Enzyme-Linked Immunosorbent Assay (ELISA) and via Ultrahigh-Performance Liquid Chromatography Coupled to Mass Spectrometry (UHPLC-MS).
Methods in molecular biology (Clifton, N.J.).
2018; 1673(?):61-72. doi:
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