Aldosterone (BioDeep_00000001290)

 

Secondary id: BioDeep_00001868204

human metabolite Endogenous blood metabolite


代谢物信息卡片


(1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydroxyacetyl)-2-methyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-ene-15-carbaldehyde

化学式: C21H28O5 (360.1936638)
中文名称: 醛甾酮 标准液
谱图信息: 最多检出来源 Homo sapiens(blood) 0.06%

分子结构信息

SMILES: CC12CCC(=O)C=C1CCC1C2C(O)CC2(C=O)C(C(=O)CO)CCC12
InChI: InChI=1S/C21H28O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,11,14-17,19,22,25H,2-7,9-10H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1

描述信息

Aldosterone is a steroid hormone produced by the adrenal cortex in the adrenal gland to regulate sodium and potassium balance in the blood. Specifically it regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium. It is synthesized from cholesterol by aldosterone synthase, which is absent in other sections of the adrenal gland. It is the sole endogenous member of the class of mineralocorticoids. Aldosterone increases the permeability of the apical (luminal) membrane of the kidneys collecting ducts to potassium and sodium and activates their basolateral Na+/K+ pumps, stimulating ATP hydrolysis, reabsorbing sodium (Na+) ions and water into the blood, and excreting potassium (K+) ions into the urine. [HMDB]
Aldosterone is a steroid hormone produced by the adrenal cortex in the adrenal gland to regulate sodium and potassium balance in the blood. Specifically, it regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium. It is synthesized from cholesterol by aldosterone synthase, which is absent in other sections of the adrenal gland. It is the sole endogenous member of the class of mineralocorticoids. Aldosterone increases the permeability of the apical (luminal) membrane of the kidneys collecting ducts to potassium and sodium and activates their basolateral Na+/K+ pumps, stimulating ATP hydrolysis, reabsorbing sodium (Na+) ions and water into the blood, and excreting potassium (K+) ions into the urine.
H - Systemic hormonal preparations, excl. sex hormones and insulins > H02 - Corticosteroids for systemic use > H02A - Corticosteroids for systemic use, plain > H02AA - Mineralocorticoids
CONFIDENCE Reference Standard (Level 1); NaToxAq - Natural Toxins and Drinking Water Quality - From Source to Tap (https://natoxaq.ku.dk)
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
CONFIDENCE standard compound; INTERNAL_ID 2819
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS

同义名列表

23 个代谢物同义名

(1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydroxyacetyl)-2-methyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-ene-15-carbaldehyde; Pregn-4-en-18-al, 11,21-dihydroxy-3,20-dioxo-, (11.beta.)-; 18-Formyl-11beta,21-dihydroxy-4-pregnene-3,20-dione; (11beta)-11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al; (11Β)-11,21-dihydroxy-3,20-dioxopregn-4-en-18-al; 11beta,21-Dihydroxy-3,20-diketopregn-4-ene-18-al; 11beta,21-dihydroxy-3,20-dioxo-pregn-4-ene-18-al; (11b)-11,21-Dihydroxy-3,20-dioxopregn-4-en-18-al; 18-Formyl-11β,21-dihydroxy-4-pregnene-3,20-dione; 11beta,21-Dihydroxy-3,20-diketo-4-pregnen-18-al; 11beta,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al; 11beta,21-Dihydroxypregn-4-ene-3,18,20-trione; 11Β,21-dihydroxy-3,20-diketopregn-4-ene-18-al; 11Β,21-dihydroxy-3,20-diketo-4-pregnen-18-al; 11b,21-Dihydroxy-3,20-dioxo-4-pregnen-18-al; 11Β,21-dihydroxy-3,20-dioxo-4-pregnen-18-al; 11Β,21-dihydroxypregn-4-ene-3,18,20-trione; Aldosterone, (11 beta,17 alpha)-isomer; Aldosterone, (+-)-isomer; 18-Oxocorticosterone; (+)-aldosterone; Aldosterone; ST 21:4;O5



数据库引用编号

54 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(9)

BioCyc(0)

PlantCyc(0)

代谢反应

72 个相关的代谢反应过程信息。

Reactome(66)

BioCyc(0)

WikiPathways(5)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(1)

PathBank(0)

PharmGKB(0)

3 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Adalaiti Maitituersun, Mulalibieke Heizhati, Nanfang Li, Lin Gan, Mei Li, Ling Yao, Wenbo Yang, Shasha Liu, Xiayire Aierken, Hui Wang, Miaomiao Liu, Jing Hong, Ting Wu, Delian Zhang, Qing Zhu. Associated lifestyle factors of elevated plasma aldosterone concentration in community population, gender-stratified analysis of a cross-sectional survey. BMC public health. 2024 May; 24(1):1370. doi: 10.1186/s12889-024-18796-0. [PMID: 38773424]
  • Harald Murck, Peter Karailiev, Lucia Karailievova, Agnesa Puhova, Daniela Jezova. Treatment with Glycyrrhiza glabra Extract Induces Anxiolytic Effects Associated with Reduced Salt Preference and Changes in Barrier Protein Gene Expression. Nutrients. 2024 Feb; 16(4):. doi: 10.3390/nu16040515. [PMID: 38398838]
  • Maura Hannon, William D Plant, Caroline Joyce, Noirin E Russell. Rare case of steroid cell tumour presenting as resistant hypertension in early pregnancy. BMJ case reports. 2023 Dec; 16(12):. doi: 10.1136/bcr-2023-255716. [PMID: 38123321]
  • Chenxiao Xu, Tao Chen, Dan Mo, Tingting Zhang, Fangli Zhou, Haoming Tian, Yan Ren. [Metabolic Outcomes of Primary Aldosteronism Patients Receiving Adrenalectomy or Spironolactone Treatments]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 2023 Nov; 54(6):1227-1232. doi: 10.12182/20231160501. [PMID: 38162054]
  • Su Liu, Yafeng Liu, Dong Zhang, Huan Li, Xicheng Shao, Pengfei Xie, Jianmei Li. Novel insights into perfluorinated compound-induced hepatotoxicity: Chronic dietary restriction exacerbates the effects of PFBS on hepatic lipid metabolism in mice. Environment international. 2023 Oct; 181(?):108274. doi: 10.1016/j.envint.2023.108274. [PMID: 37879206]
  • Zixuan Li, Bernard Robaire, Barbara F Hales. The Organophosphate Esters Used as Flame Retardants and Plasticizers affect H295R Adrenal Cell Phenotypes and Functions. Endocrinology. 2023 Jul; ?(?):. doi: 10.1210/endocr/bqad119. [PMID: 37522340]
  • Juan Valentín-Goyco, Jiayan Liu, Hwei-Ming Peng, Jerry Oommen, Richard J Auchus. Selectivity of osilodrostat as an inhibitor of human steroidogenic cytochromes P450. The Journal of steroid biochemistry and molecular biology. 2023 07; 231(?):106316. doi: 10.1016/j.jsbmb.2023.106316. [PMID: 37098354]
  • Elizabeth Brammer-Robbins, Mohammad-Zaman Nouri, Emily K Griffin, Juan Aristizabal-Henao, Nancy D Denslow, John A Bowden, Iske V Larkin, Christopher J Martyniuk. Assessment of lipids and adrenal hormones in the Florida manatee (Trichechus manatus latirostris) from different habitats. General and comparative endocrinology. 2023 06; 337(?):114250. doi: 10.1016/j.ygcen.2023.114250. [PMID: 36858274]
  • Yicong Yin, Chaochao Ma, Songlin Yu, Qing Ai, Chuntao Han, Jian Zhong, Wei Luo, Xiaoli Ma, Jialei Yu, Yuanyuan Zhang, Jingwen Cui, Ling Qiu. Reference intervals for LC-MS /MS measurements of plasma renin activity, aldosterone, angiotensin II, and 24-hour urinary aldosterone in Northern Chinese Han population. Clinica chimica acta; international journal of clinical chemistry. 2023 Mar; 543(?):117325. doi: 10.1016/j.cca.2023.117325. [PMID: 37003517]
  • Turgay Saritas, Jürgen Floege. [Retarding progression of chronic kidney disease]. Innere Medizin (Heidelberg, Germany). 2023 Mar; 64(3):240-246. doi: 10.1007/s00108-023-01482-5. [PMID: 36723710]
  • Folarin Owagboriaye, Oladunni Adekunle, Rasheed Oladunjoye, Mistura Adeleke, Sulaimon Aina, Adedamola Adenekan, Pamilerin Bakare, Oyebamiji Fafioye, Gabriel Dedeke, Olusegun Lawal. Implications of atrazine concentrations in drinking water from Ijebu-North, Southwest Nigeria on the hypothalamic-pituitary-adrenal axis. Drug and chemical toxicology. 2023 Feb; ?(?):1-9. doi: 10.1080/01480545.2023.2180025. [PMID: 36847489]
  • Shotaro Miyamoto, Yuichi Yoshida, Yoshinori Ozeki, Mitsuhiro Okamoto, Koro Gotoh, Takayuki Masaki, Haruto Nishida, Hiroyuki Fujinami, Toshitaka Shin, Tsutomu Daa, Yoshiki Asayama, Hirotaka Shibata. Pitfalls in the diagnosis and treatment of a hypertensive patient with unilateral primary aldosteronism and contralateral pheochromocytoma: a case report. BMC endocrine disorders. 2023 Feb; 23(1):44. doi: 10.1186/s12902-023-01297-3. [PMID: 36797699]
  • Shinjini C Spaulding, Vivek Choudhary, Wendy B Bollag. Phospholipase D mediates very low-density lipoprotein-induced aldosterone production, in part, via lipin-1. Journal of molecular endocrinology. 2023 Feb; ?(?):. doi: 10.1530/jme-22-0196. [PMID: 36779781]
  • Uei-Lin Chen, Che-Wei Liao, Shuo-Meng Wang, Tai-Shuan Lai, Kuo-How Huang, Chin-Chen Chang, Bo-Ching Lee, Ching-Chu Lu, Yi-Ru Chang, Yi-Yao Chang, Chi-Sheng Hung, Jeff S Chueh, Vin-Cent Wu, Cheng-Hsuan Tsai, Yen-Hung Lin. Diabetes mellitus is associated with more adverse non-hemodynamic left ventricular remodeling and less recovery in patients with primary aldosteronism. Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 2023 02; 71(2):101-112. doi: 10.1177/10815589221141840. [PMID: 36647318]
  • Shixun Zhong, Biyun Zhang, Li Qin, Qianying Wang, Xiaoli Luo. Aldosterone inhibits Dot1l expression in guinea pig cochlea. European journal of medical research. 2023 Jan; 28(1):26. doi: 10.1186/s40001-023-00994-y. [PMID: 36639782]
  • Felix Atmanspacher, Rolf Schreckenberg, Annemarie Wolf, Ivica Grgic, Klaus-Dieter Schlüter. Effect of Metabolic Adaptation by Voluntary Running Wheel Activity and Aldosterone Inhibition on Renal Function in Female Spontaneously Hypertensive Rats. Cells. 2022 12; 11(24):. doi: 10.3390/cells11243954. [PMID: 36552716]
  • Jing Gao, Abolfazl Akbari, Tao Wang. Green tea could improve elderly hypertension by modulating arterial stiffness, the activity of the renin/angiotensin/aldosterone axis, and the sodium-potassium pumps in old male rats. Journal of food biochemistry. 2022 12; 46(12):e14398. doi: 10.1111/jfbc.14398. [PMID: 36181277]
  • Thomas Weber, Jaques Amar, Tine de Backer, Thilo Burkard, Marcus van der Giet, Philippe Gosse, Andrzej Januszewicz, Thomas Kahan, Giuseppe Mancia, Christopher C Mayer, Maria Lorenza Muiesan, George S Stergiou, Konstantinos Tsioufis, Bernard Vaisse, Reinhold Kreutz. Covid-19 associated reduction in hypertension-related diagnostic and therapeutic procedures in Excellence Centers of the European Society of Hypertension. Blood pressure. 2022 12; 31(1):71-79. doi: 10.1080/08037051.2022.2060182. [PMID: 35465794]
  • Jack L Hulse, Javad Habibi, Aderonke E Igbekele, Bingyue Zhang, Jessie Li, Adam Whaley-Connell, James R Sowers, Guanghong Jia. Mineralocorticoid Receptors Mediate Diet-Induced Lipid Infiltration of Skeletal Muscle and Insulin Resistance. Endocrinology. 2022 10; 163(11):. doi: 10.1210/endocr/bqac145. [PMID: 36039677]
  • Hakan Doneray, Ozlem Ziraatci Akbulut, Ayse Ozden, Abdulkadir Yildirim, Zerrin Orbak. Plasma renin, aldosterone, and urinary prostaglandin E2 levels in children with hypocalcemia due to vitamin D deficiency rickets. Prostaglandins & other lipid mediators. 2022 10; 162(?):106652. doi: 10.1016/j.prostaglandins.2022.106652. [PMID: 35688409]
  • Patrícia Regina Terço Leite, Bethânia Rosa Lorençone, Karyne Garcia Tafarelo Moreno, Katiana Simões Lopes, Aline Aparecida Macedo Marques, Clara Soligo Fortini, Rhanany Alan Calloi Palozi, Mariana Dalmagro, Cândida Aparecida Leite Kassuya, Ariany Carvalho Dos Santos, Marcos José Salvador, Arquimedes Gasparotto Junior. The NO-cGMP-K+ Channel Pathway Participates in Diuretic and Cardioprotective Effects of Blutaparon portulacoides in Spontaneously Hypertensive Rats. Planta medica. 2022 Oct; 88(13):1152-1162. doi: 10.1055/a-1690-3566. [PMID: 35299274]
  • Oyunbileg Bavuu, Daiju Fukuda, Byambasuren Ganbaatar, Tomomi Matsuura, Takayuki Ise, Kenya Kusunose, Koji Yamaguchi, Shusuke Yagi, Hirotsugu Yamada, Takeshi Soeki, Tetsuzo Wakatsuki, Masataka Sata. Esaxerenone, a selective mineralocorticoid receptor blocker, improves insulin sensitivity in mice consuming high-fat diet. European journal of pharmacology. 2022 Sep; 931(?):175190. doi: 10.1016/j.ejphar.2022.175190. [PMID: 35961594]
  • Bidisha Paul, Zachary R Sterner, Ruchika Bhawal, Elizabeth T Anderson, Sheng Zhang, Daniel R Buchholz. Impaired negative feedback and death following acute stress in glucocorticoid receptor knockout Xenopus tropicalis tadpoles. General and comparative endocrinology. 2022 09; 326(?):114072. doi: 10.1016/j.ygcen.2022.114072. [PMID: 35697317]
  • Ariadni Spyroglou, Laura Handgriff, Lisa Müller, Paul Schwarzlmüller, Mirko Parasiliti-Caprino, Carmina Teresa Fuss, Hana Remde, Anna Hirsch, Samuel Matthew O'Toole, Moe Thuzar, Luigi Petramala, Claudio Letizia, Elisa Deflorenne, Laurence Amar, Rok Vrckovnik, Tomaz Kocjan, Catherine D Zhang, Dingfeng Li, Sumitabh Singh, Takuyuki Katabami, Takashi Yoneda, Masanori Murakami, Norio Wada, Nobuya Inagaki, Marcus Quinkler, Ezio Ghigo, Mauro Maccario, Michael Stowasser, William M Drake, Martin Fassnacht, Irina Bancos, Martin Reincke, Mitsuhide Naruse, Felix Beuschlein. The metabolic phenotype of patients with primary aldosteronism: impact of subtype and sex - a multicenter-study of 3566 Caucasian and Asian subjects. European journal of endocrinology. 2022 Sep; 187(3):361-372. doi: 10.1530/eje-22-0040. [PMID: 35895721]
  • Taha Sen, Rosalie Scholtes, Peter J Greasley, David Z I Cherney, Claire C J Dekkers, Marc Vervloet, Alexander H J Danser, Sean J Barbour, Cecilia Karlsson, Ann Hammarstedt, Qiang Li, Gozewijn D Laverman, Petter Bjornstad, Daniel H van Raalte, Hiddo J L Heerspink. Effects of dapagliflozin on volume status and systemic haemodynamics in patients with chronic kidney disease without diabetes: Results from DAPASALT and DIAMOND. Diabetes, obesity & metabolism. 2022 Aug; 24(8):1578-1587. doi: 10.1111/dom.14729. [PMID: 35478433]
  • Reham S Ibrahim, Nesrine S El-Mezayen, Alaa A El-Banna. Alleviation of liver cirrhosis and associated portal-hypertension by Astragalus species in relation to their UPLC-MS/MS metabolic profiles: a mechanistic study. Scientific reports. 2022 Jul; 12(1):11884. doi: 10.1038/s41598-022-15958-1. [PMID: 35831335]
  • Barbara Schreier, Alexander Zipprich, Henriette Uhlenhaut, Michael Gekle. Mineralocorticoid receptors in non-alcoholic fatty liver disease. British journal of pharmacology. 2022 07; 179(13):3165-3177. doi: 10.1111/bph.15784. [PMID: 34935140]
  • Johann Bauersachs, Natalia López-Andrés. Mineralocorticoid receptor in cardiovascular diseases-Clinical trials and mechanistic insights. British journal of pharmacology. 2022 07; 179(13):3119-3134. doi: 10.1111/bph.15708. [PMID: 34643952]
  • Shinichi Tamaru, Hirotsugu Suwanai, Hironori Abe, Junko Sasaki, Keitaro Ishii, Hajime Iwasaki, Jumpei Shikuma, Rokuro Ito, Takashi Miwa, Toru Sasaki, Tomoko Takamiya, Shigeru Inoue, Kazuhiro Saito, Masato Odawara, Ryo Suzuki. Machine learning approach to predict subtypes of primary aldosteronism is helpful to estimate indication of adrenal vein sampling. High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension. 2022 Jul; 29(4):375-383. doi: 10.1007/s40292-022-00523-8. [PMID: 35576101]
  • Dorien Clarisse, Lisa Deng, Karolien de Bosscher, Achim Lother. Approaches towards tissue-selective pharmacology of the mineralocorticoid receptor. British journal of pharmacology. 2022 07; 179(13):3235-3249. doi: 10.1111/bph.15719. [PMID: 34698367]
  • Jingru Liang, Hang Dong, Hongsheng Wang, Zhengjun Yi, Guosheng Jiang, Takashi Inagaki, Celso E Gomez-Sanchez, Jinhua Dong, Hiroshi Ueda. Creation of a quick and sensitive fluorescent immunosensor for detecting the mineralocorticoid steroid hormone aldosterone. The Journal of steroid biochemistry and molecular biology. 2022 07; 221(?):106118. doi: 10.1016/j.jsbmb.2022.106118. [PMID: 35487440]
  • Karanjeet Chauhan, Eitan Schachna, Renata Libianto, Jessica Ryan, Holly Hutton, Peter J Fuller, Scott Wilson, Peter G Kerr, Jun Yang. Screening for primary aldosteronism is underutilised in patients with chronic kidney disease. Journal of nephrology. 2022 Jul; 35(6):1667-1677. doi: 10.1007/s40620-022-01267-3. [PMID: 35195879]
  • Yujiro Maeoka, Xiao-Tong Su, Wen-Hui Wang, Xin-Peng Duan, Avika Sharma, Na Li, Olivier Staub, James A McCormick, David H Ellison. Mineralocorticoid Receptor Antagonists Cause Natriuresis in the Absence of Aldosterone. Hypertension (Dallas, Tex. : 1979). 2022 07; 79(7):1423-1434. doi: 10.1161/hypertensionaha.122.19159. [PMID: 35506380]
  • Shogo Harashima, Yuto Yamazaki, Naoki Motomura, Yoshikiyo Ono, Kei Omata, Yuta Tezuka, Ryo Morimoto, Yasuhiro Nakamura, Fumitoshi Satoh, Hiroyoshi Suzuki, Go Eun Kwon, Man Ho Choi, Hironobu Sasano. Phenotype-genotype correlation in aldosterone-producing adenomas characterized by intracellular cholesterol metabolism. The Journal of steroid biochemistry and molecular biology. 2022 07; 221(?):106116. doi: 10.1016/j.jsbmb.2022.106116. [PMID: 35533918]
  • Priyanka Khandelwal, Jaap Deinum. Monogenic forms of low-renin hypertension: clinical and molecular insights. Pediatric nephrology (Berlin, Germany). 2022 07; 37(7):1495-1509. doi: 10.1007/s00467-021-05246-x. [PMID: 34414500]
  • Yasuaki Dohi. Plasma B-type natriuretic peptide level as a possible predictor of dietary salt intake. Hypertension research : official journal of the Japanese Society of Hypertension. 2022 Jul; 45(7):1134-1135. doi: 10.1038/s41440-022-00938-9. [PMID: 35581499]
  • Anna Keppner, Darko Maric, Ilaria Maria Christina Orlando, Laurent Falquet, Edith Hummler, David Hoogewijs. Analysis of the Hypoxic Response in a Mouse Cortical Collecting Duct-Derived Cell Line Suggests That Esrra Is Partially Involved in Hif1α-Mediated Hypoxia-Inducible Gene Expression in mCCDcl1 Cells. International journal of molecular sciences. 2022 Jun; 23(13):. doi: 10.3390/ijms23137262. [PMID: 35806266]
  • Elodie Ehret, Yannick Jäger, Chloé Sergi, Anne-Marie Mérillat, Thibaud Peyrollaz, Deepika Anand, Qing Wang, Fréderique Ino, Marc Maillard, Stephan Kellenberger, Ivan Gautschi, Roman Szabo, Thomas H Bugge, Lotte K Vogel, Edith Hummler, Simona Frateschi. Kidney-Specific CAP1/Prss8-Deficient Mice Maintain ENaC-Mediated Sodium Balance through an Aldosterone Independent Pathway. International journal of molecular sciences. 2022 Jun; 23(12):. doi: 10.3390/ijms23126745. [PMID: 35743186]
  • Toshifumi Nakamura, Benjamin Bonnard, Roberto Palacios-Ramirez, Amaya Fernández-Celis, Frédéric Jaisser, Natalia López-Andrés. Biglycan Is a Novel Mineralocorticoid Receptor Target Involved in Aldosterone/Salt-Induced Glomerular Injury. International journal of molecular sciences. 2022 Jun; 23(12):. doi: 10.3390/ijms23126680. [PMID: 35743123]
  • Jordan Loader, Frances C Taylor, Erik Lampa, Johan Sundström. Renin-Angiotensin Aldosterone System Inhibitors and COVID-19: A Systematic Review and Meta-Analysis Revealing Critical Bias Across a Body of Observational Research. Journal of the American Heart Association. 2022 06; 11(11):e025289. doi: 10.1161/jaha.122.025289. [PMID: 35624081]
  • Cheng-Hsuan Tsai, Che-Wei Liao, Xue-Ming Wu, Zheng-Wei Chen, Chien-Ting Pan, Yi-Yao Chang, Bo-Ching Lee, Chia-Tung Shun, Wen-Fen Wen, Chia-Hung Chou, Vin-Cent Wu, Chi-Sheng Hung, Yen-Hung Lin. Autonomous cortisol secretion is associated with worse arterial stiffness and vascular fibrosis in primary aldosteronism: a cross-sectional study with follow-up data. European journal of endocrinology. 2022 Jun; 187(1):197-208. doi: 10.1530/eje-21-1157. [PMID: 35551115]
  • Rosalieke E Wiegel, Damiat Aoulad Fares, Sten P Willemsen, Eric A P Steegers, A H Jan Danser, Régine P M Steegers-Theunissen. First-trimester maternal renin-angiotensin-aldosterone system activation and fetal growth and birthweight: the Rotterdam Periconceptional Cohort. Reproductive biomedicine online. 2022 06; 44(6):1110-1122. doi: 10.1016/j.rbmo.2021.12.020. [PMID: 35379566]
  • Hiten D Mistry, Rahel Klossner, Sampada Kallol, Michael P Lüthi, Ruedi Moser, Henning Schneider, Edgar C Ontsouka, Lesia O Kurlak, Markus G Mohaupt, Christiane Albrecht. Effects of aldosterone on the human placenta: Insights from placental perfusion studies. Placenta. 2022 06; 123(?):32-40. doi: 10.1016/j.placenta.2022.03.129. [PMID: 35537250]
  • Bora Gulhan, Yağmur Ünsal, Demet Baltu, Nur Berna Çelik Ertaş, Gülşah Özdemir, Eda Utine, H Nursun Ozcan, Ali Duzova, Nazli Gönç. Apparent mineralocorticoid excess: A diagnosis beyond classical causes of severe hypertension in a child. Blood pressure monitoring. 2022 Jun; 27(3):208-211. doi: 10.1097/mbp.0000000000000583. [PMID: 35044984]
  • Matthias B Moor, Nasser A Dhayat, Simeon Schietzel, Michael Grössl, Bruno Vogt, Daniel G Fuster. Urinary tetrahydroaldosterone is associated with circulating FGF23 in kidney stone formers. Urolithiasis. 2022 Jun; 50(3):333-340. doi: 10.1007/s00240-022-01317-2. [PMID: 35201364]
  • Shangyan Liang, Qingling Li, Qianwei Lai, Ying Zhou, Hui Zhang, Xueyan Chen, Bin Yao, Wen Xu, Xubin Yang. Beta-2-Microglobulin is an Independent Risk Factor for Asymptomatic Carotid Atherosclerosis in Patients with Primary Aldosteronism. Journal of atherosclerosis and thrombosis. 2022 Jun; 29(6):937-952. doi: 10.5551/jat.62851. [PMID: 34305082]
  • Barbara Fischer, Andreas Serra, Harry Telser. Cost-Effectiveness of Treating Patients with Chronic Kidney Disease and Prior Hyperkalemia with Renin-Angiotensin-Aldosterone System Inhibitor and Patiromer: A Swiss Public Healthcare Perspective. Advances in therapy. 2022 06; 39(6):2717-2730. doi: 10.1007/s12325-022-02123-3. [PMID: 35416597]
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