5-Hydroxyindoleacetic acid (BioDeep_00000001263)
Secondary id: BioDeep_00000397977, BioDeep_00000400111, BioDeep_00000405361
natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite
代谢物信息卡片
化学式: C10H9NO3 (191.0582404)
中文名称: 5-羟基吲哚-3-乙酸, 5-羟吲哚乙酸, (5-羟基-1H-吲哚-3-基)乙酸
谱图信息:
最多检出来源 Homo sapiens(feces) 0.67%
Last reviewed on 2024-07-17.
Cite this Page
5-Hydroxyindoleacetic acid. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/5-hydroxyindoleacetic_acid (retrieved
2024-11-03) (BioDeep RN: BioDeep_00000001263). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: c1(ccc2c(c1)c(c[nH]2)CC(=O)O)O
InChI: InChI=1S/C10H9NO3/c12-7-1-2-9-8(4-7)6(5-11-9)3-10(13)14/h1-2,4-5,11-12H,3H2,(H,13,14)
描述信息
5-Hydroxyindoleacetic acid, also known as 5-hydroxyindole-3-acetate or 5-HIAA, belongs to the class of organic compounds known as indole-3-acetic acid derivatives. Indole-3-acetic acid derivatives are compounds containing an acetic acid (or a derivative) linked to the C3 carbon atom of an indole. 5-Hydroxyindoleacetic acid exists in all living organisms, ranging from bacteria to humans. In humans, 5-hydroxyindoleacetic acid is a breakdown product of serotonin that is excreted in the urine and it also participates in a number of enzymatic reactions. 5-hydroxyindoleacetic acid can be biosynthesized from 5-hydroxyindoleacetaldehyde; which is catalyzed by the mitochondrial enzyme aldehyde dehydrogenase. In addition, 5-hydroxyindoleacetic acid and S-adenosylmethionine can be converted into 5-methoxyindoleacetate and S-adenosylhomocysteine through its interaction with the enzyme acetylserotonin O-methyltransferase. 5-Hydroxyindoleacetic acid is also involved in the metabolism of tryptophan. 5-Hydroxyindoleacetic acid has been found to be associated with several human diseases such as brunner syndrome, friedreichs ataxia, schizophrenia, and olivopontocerebral atrophy; 5-hydroxyindoleacetic acid has also been linked to the inborn metabolic disorder sepiapterin reductase deficiency. Elevated levels of 5-hydroxyindoleacetic acid in urine (>20 uM) are indicative of appendicitis and gastroenteritis (PMID: 11462886). Serotonin and 5-Hydroxyindoleacetic acid are produced in excess amounts by carcinoid tumors, and levels of these substances may be measured in the urine to test for carcinoid tumors (NCI). 5-Hydroxyindoleacetic acid has also been found to be a product of human gut microbiota.
5-Hydroxyindoleacetic acid (5-HIAA) is the main metabolite of serotonin in the human body. In chemical analysis of urine samples, 5-HIAA is used to determine the bodys levels of serotonin. 5-Hydroxyindole-3-acetic acid is found in many foods, some of which are pitanga, dandelion, coconut, and white cabbage.
5-Hydroxyindole-3-acetic acid is the main metabolite of serotonin or metanephrines, which can be used as a biomarker of neuroendocrine tumors.
同义名列表
31 个代谢物同义名
2-(5-hydroxy-1H-indol-3-yl)acetic acid; 5-Hydroxy-1H-indole-3-acetic acid; Acid, 5-hydroxyindolamine acetic; Acetic acid, 5-hydroxyindolamine; 5 Hydroxyindolamine acetic acid; 5-Hydroxyindolamine acetic acid; 5-Hydroxy-indole-3-acetic acid; 5-Hydroxyindol-3-ylacetic acid; Acid, 5-hydroxy-3-indoleacetic; 5-Hydroxy-3-indoleacetic acid; 5 Hydroxy 3 indoleacetic acid; 5-Hydroxy-1H-indole-3-acetate; 5-Hydroxyindole-3-acetic acid; 5-Hydroxy-3-indoleaceacetate; 5-Hydroxy-indole-3-acetate; 5-Hydroxyindoleacetic acid; 5-Hydroxy-3-indolylacetate; 5-Hydroxyindol-3-ylacetate; Acid, hydroxyindoleacetic; 5-Hydroxyindole-3-acetate; Hydroxyindoleacetic acid; 5-Hydroxyindole acetate; 5-Oxyindoleacetic acid; 5-Hydroxyindoleacetate; 5-Hydroxyheteroauxin; Hydroxyindoleacetate; 5-Oxyindoleacetate; 5-Hydroxy-iaa; 5-HIAA; 5HIAA; 5-Hydroxyindole-3-acetic Acid
数据库引用编号
41 个数据库交叉引用编号
- ChEBI: CHEBI:27823
- KEGG: C05635
- PubChem: 1826
- HMDB: HMDB0000763
- Metlin: METLIN2975
- ChEMBL: CHEMBL395915
- Wikipedia: 5-Hydroxyindoleacetic_acid
- MeSH: Hydroxyindoleacetic Acid
- MetaCyc: 5-HYDROXYINDOLE_ACETATE
- KNApSAcK: C00000104
- foodb: FDB001403
- chemspider: 1760
- CAS: 54-16-0
- MoNA: KO003127
- MoNA: AU279505
- MoNA: KO003124
- MoNA: PS096807
- MoNA: PS096803
- MoNA: KO003125
- MoNA: KO001069
- MoNA: KO001067
- MoNA: KO003123
- MoNA: KO001070
- MoNA: PS096809
- MoNA: AU279506
- MoNA: AU279501
- MoNA: KO001068
- MoNA: PS096801
- MoNA: KO001066
- MoNA: KO003126
- MoNA: PS096804
- MoNA: AU279504
- MoNA: AU279503
- MoNA: PS096802
- PMhub: MS000000228
- PDB-CCD: HID
- 3DMET: B00815
- NIKKAJI: J11.030B
- RefMet: 5-Hydroxyindoleacetic acid
- RefMet: Hydroxyindoleacetic acid
- medchemexpress: HY-W008253
分类词条
相关代谢途径
Reactome(5)
BioCyc(0)
PlantCyc(0)
代谢反应
94 个相关的代谢反应过程信息。
Reactome(85)
- Neuronal System:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP
- Neuronal System:
ATP + L-Glu + NH4+ ⟶ ADP + L-Gln + Pi
- Transmission across Chemical Synapses:
ATP + L-Glu + NH4+ ⟶ ADP + L-Gln + Pi
- Neurotransmitter clearance:
HIALD + NAD ⟶ H+ + HIAA + NADH
- Clearance of seratonin:
HIALD + NAD ⟶ H+ + HIAA + NADH
- Metabolism of serotonin:
HIALD + NAD ⟶ H+ + HIAA + NADH
- Neuronal System:
DA + SAM ⟶ 3MT + SAH
- Transmission across Chemical Synapses:
DA + SAM ⟶ 3MT + SAH
- Neurotransmitter clearance:
DA + SAM ⟶ 3MT + SAH
- Clearance of seratonin:
5HT + H2O + Oxygen ⟶ 5HIALD + H2O2 + ammonia
- Metabolism of serotonin:
5HT + H2O + Oxygen ⟶ 5HIALD + H2O2 + ammonia
- Transmission across Chemical Synapses:
DA + SAM ⟶ 3MT + SAH
- Transmission across Chemical Synapses:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP
- Neurotransmitter clearance:
AcCho + H2O ⟶ Cho + acetate
- Clearance of seratonin:
HIALD + NAD ⟶ H+ + HIAA + NADH
- Metabolism of serotonin:
HIALD + NAD ⟶ H+ + HIAA + NADH
- Neuronal System:
DA + SAM ⟶ 3MT + SAH
- Transmission across Chemical Synapses:
DA + SAM ⟶ 3MT + SAH
- Neurotransmitter clearance:
DA + SAM ⟶ 3MT + SAH
- Clearance of seratonin:
5HT + H2O + Oxygen ⟶ 5HIALD + H2O2 + ammonia
- Metabolism of serotonin:
5HT + H2O + Oxygen ⟶ 5HIALD + H2O2 + ammonia
- Neuronal System:
DA + SAM ⟶ 3MT + SAH
- Metabolism of serotonin:
HIALD + NAD ⟶ H+ + HIAA + NADH
- Neurotransmitter clearance:
DA + SAM ⟶ 3MT + SAH
- Clearance of seratonin:
HIALD + NAD ⟶ H+ + HIAA + NADH
- Metabolism of serotonin:
HIALD + NAD ⟶ H+ + HIAA + NADH
- Neuronal System:
3MT + H2O + Oxygen ⟶ H2O2 + HVA + ammonia
- Transmission across Chemical Synapses:
3MT + H2O + Oxygen ⟶ H2O2 + HVA + ammonia
- Neurotransmitter clearance:
3MT + H2O + Oxygen ⟶ H2O2 + HVA + ammonia
- Clearance of seratonin:
5HT + H2O + Oxygen ⟶ 5HIALD + H2O2 + ammonia
- Metabolism of serotonin:
5HT + H2O + Oxygen ⟶ 5HIALD + H2O2 + ammonia
- Neuronal System:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP
- Transmission across Chemical Synapses:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP
- Neurotransmitter clearance:
AcCho + H2O ⟶ Cho + acetate
- Clearance of seratonin:
HIALD + NAD ⟶ H+ + HIAA + NADH
- Neuronal System:
DA + SAM ⟶ 3MT + SAH
- Transmission across Chemical Synapses:
DA + SAM ⟶ 3MT + SAH
- Neurotransmitter clearance:
DA + SAM ⟶ 3MT + SAH
- Clearance of seratonin:
5HT + H2O + Oxygen ⟶ 5HIALD + H2O2 + ammonia
- Metabolism of serotonin:
5HT + H2O + Oxygen ⟶ 5HIALD + H2O2 + ammonia
- Neuronal System:
DA + SAM ⟶ 3MT + SAH
- Transmission across Chemical Synapses:
DA + SAM ⟶ 3MT + SAH
- Neurotransmitter clearance:
DA + SAM ⟶ 3MT + SAH
- Clearance of seratonin:
5HT + H2O + Oxygen ⟶ 5HIALD + H2O2 + ammonia
- Metabolism of serotonin:
5HT + H2O + Oxygen ⟶ 5HIALD + H2O2 + ammonia
- Neuronal System:
DA + SAM ⟶ 3MT + SAH
- Transmission across Chemical Synapses:
DA + SAM ⟶ 3MT + SAH
- Neurotransmitter clearance:
DA + SAM ⟶ 3MT + SAH
- Clearance of seratonin:
5HT + H2O + Oxygen ⟶ 5HIALD + H2O2 + ammonia
- Metabolism of serotonin:
5HT + H2O + Oxygen ⟶ 5HIALD + H2O2 + ammonia
- Neuronal System:
HCN channels + cAMP ⟶ HCN channel bound to cAMP
- Transmission across Chemical Synapses:
ATP ⟶ ADP
- Neurotransmitter clearance:
HIALD + NAD ⟶ H+ + HIAA + NADH
- Clearance of seratonin:
HIALD + NAD ⟶ H+ + HIAA + NADH
- Metabolism of serotonin:
HIALD + NAD ⟶ H+ + HIAA + NADH
- Neuronal System:
DA + SAM ⟶ 3MT + SAH
- Transmission across Chemical Synapses:
DA + SAM ⟶ 3MT + SAH
- Neurotransmitter clearance:
DA + SAM ⟶ 3MT + SAH
- Clearance of seratonin:
5HT + H2O + Oxygen ⟶ 5HIALD + H2O2 + ammonia
- Metabolism of serotonin:
5HT + H2O + Oxygen ⟶ 5HIALD + H2O2 + ammonia
- Neuronal System:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP
- Transmission across Chemical Synapses:
PKA tetramer + cAMP ⟶ PKA tetramer:4xcAMP
- Neurotransmitter clearance:
HIALD + NAD ⟶ H+ + HIAA + NADH
- Clearance of seratonin:
HIALD + NAD ⟶ H+ + HIAA + NADH
- Metabolism of serotonin:
HIALD + NAD ⟶ H+ + HIAA + NADH
- Neuronal System:
DA + SAM ⟶ 3MT + SAH
- Transmission across Chemical Synapses:
DA + SAM ⟶ 3MT + SAH
- Neurotransmitter clearance:
DA + SAM ⟶ 3MT + SAH
- Neuronal System:
DA + SAM ⟶ 3MT + SAH
- Transmission across Chemical Synapses:
DA + SAM ⟶ 3MT + SAH
- Neurotransmitter clearance:
DA + SAM ⟶ 3MT + SAH
- Clearance of seratonin:
HIALD + NAD ⟶ H+ + HIAA + NADH
- Metabolism of serotonin:
HIALD + NAD ⟶ H+ + HIAA + NADH
- Neuronal System:
DA + SAM ⟶ 3MT + SAH
- Transmission across Chemical Synapses:
DA + SAM ⟶ 3MT + SAH
- Neurotransmitter clearance:
DA + SAM ⟶ 3MT + SAH
- Clearance of seratonin:
5HT + H2O + Oxygen ⟶ 5HIALD + H2O2 + ammonia
- Metabolism of serotonin:
5HT + H2O + Oxygen ⟶ 5HIALD + H2O2 + ammonia
- Neuronal System:
DA + SAM ⟶ 3MT + SAH
- Transmission across Chemical Synapses:
DA + SAM ⟶ 3MT + SAH
- Neurotransmitter clearance:
DA + SAM ⟶ 3MT + SAH
- Clearance of seratonin:
HIALD + NAD ⟶ H+ + HIAA + NADH
- Metabolism of serotonin:
HIALD + NAD ⟶ H+ + HIAA + NADH
- Clearance of seratonin:
HIALD + NAD ⟶ H+ + HIAA + NADH
- Metabolism of serotonin:
HIALD + NAD ⟶ H+ + HIAA + NADH
BioCyc(0)
WikiPathways(3)
- Neurotransmitter disorders:
Dopamine ⟶ 3-Methoxytyramine
- Melatonin metabolism and effects:
Serotonin ⟶ 5-Hydroxyindoleacetic acid
- Biosynthesis and regeneration of tetrahydrobiopterin and catabolism of phenylalanine:
5-OH-Trp ⟶ Serotonin
Plant Reactome(0)
INOH(1)
- Tryptophan degradation ( Tryptophan degradation ):
L-Tryptophan + O2 ⟶ N-Formyl-L-kynurenine
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(5)
- Tryptophan Metabolism:
L-Tryptophan + Oxygen ⟶ N'-Formylkynurenine
- Tryptophan Metabolism:
L-Tryptophan + Oxygen ⟶ N'-Formylkynurenine
- Tryptophan Metabolism:
L-Tryptophan + Oxygen ⟶ N'-Formylkynurenine
- Tryptophan Metabolism:
L-Tryptophan + Oxygen ⟶ N'-Formylkynurenine
- Tryptophan Metabolism:
L-Tryptophan + Oxygen ⟶ N'-Formylkynurenine
PharmGKB(0)
8 个相关的物种来源信息
- 654 - Aeromonas veronii: 10.3389/FCIMB.2020.00044
- 6669 - Daphnia pulex: 10.1038/SREP25125
- 3039 - Euglena gracilis: 10.3389/FBIOE.2021.662655
- 3850 - Griffonia simplicifolia: 10.1016/S0031-9422(00)85745-3
- 9606 - Homo sapiens:
- 9606 - Homo sapiens: -
- 681275 - Litoria verreauxii: 10.1038/SDATA.2018.33
- 5691 - Trypanosoma brucei: 10.1128/AAC.00044-13
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Minglan Wu, Qi Wang, Xiaodong Li, Songxia Yu, Fan Zhao, Xia Wu, Li Fan, Xueling Liu, Qingwei Zhao, Xuelin He, Weifen Li, Qiao Zhang, Xingjiang Hu. Gut microbiota-derived 5-hydroxyindoleacetic acid from pumpkin polysaccharides supplementation alleviates colitis via MAPKs-PPARγ/NF-κB inhibition.
International journal of biological macromolecules.
2024 Apr; 264(Pt 1):130385. doi:
10.1016/j.ijbiomac.2024.130385
. [PMID: 38395290] - Dinara Sadykova, Razina Nigmatullina, Karina Salakhova, Evgeniia Slastnikova, Liliya Galimova, Chulpan Khaliullina, Ildaria Valeeva. Membrane Transporter of Serotonin and Hypercholesterolemia in Children.
International journal of molecular sciences.
2024 Jan; 25(2):. doi:
10.3390/ijms25020767
. [PMID: 38255840] - Zhitao Hou, Xinyu Yang, Ling Jiang, Liying Song, Yang Li, Dongdong Li, Yanning Che, Xiuling Zhang, Zhongren Sun, Hongcai Shang, Jing Chen. Active components and molecular mechanisms of Sagacious Confucius' Pillow Elixir to treat cognitive impairment based on systems pharmacology.
Aging.
2023 07; 15(14):7278-7307. doi:
10.18632/aging.204912
. [PMID: 37517091] - Mariana Silva Cardoso, Andrea Rebouças Rocha, José Antônio Souza-Júnior, José Antonio Menezes-Filho. Analytical method for urinary homovanillic acid and 5-hydroxyindoleacetic acid levels using HPLC with electrochemical detection applied to evaluate children environmentally exposed to manganese.
Biomedical chromatography : BMC.
2023 Jul; ?(?):e5699. doi:
10.1002/bmc.5699
. [PMID: 37427763] - Wei Shen, Yanlin Tao, Fang Zheng, Houyuan Zhou, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu. The alteration of gut microbiota in venlafaxine-ameliorated chronic unpredictable mild stress-induced depression in mice.
Behavioural brain research.
2023 Mar; 446(?):114399. doi:
10.1016/j.bbr.2023.114399
. [PMID: 36963638] - Yabing Li, Brijen Miyani, Liang Zhao, Maddie Spooner, Zach Gentry, Yangyang Zou, Geoff Rhodes, Hui Li, Andrew Kaye, John Norton, Irene Xagoraraki. Surveillance of SARS-CoV-2 in nine neighborhood sewersheds in Detroit Tri-County area, United States: Assessing per capita SARS-CoV-2 estimations and COVID-19 incidence.
The Science of the total environment.
2022 Dec; 851(Pt 2):158350. doi:
10.1016/j.scitotenv.2022.158350
. [PMID: 36041621] - Ping Tian, Wei Zhang, Kai-Yan Li, Hong-Wei Li, Kai Ma, De-En Han. [Effect of Rehmanniae Radix on depression-like behavior and hippocampal monoamine neurotransmitters of chronic unpredictable mild stress model rats].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica.
2022 Sep; 47(17):4691-4697. doi:
10.19540/j.cnki.cjcmm.20220421.401
. [PMID: 36164876] - Shang Lyu, Yi Rao, Peng Liu, Shilin Yang, Wanyuan Chen, Huajie Yang, Shiwen Ke, Hui OuYang, Mingzhen He, Yulin Feng. Metabolomics analysis reveals four biomarkers associated with the gouty arthritis progression in patients with sequential stages.
Seminars in arthritis and rheumatism.
2022 08; 55(?):152022. doi:
10.1016/j.semarthrit.2022.152022
. [PMID: 35584580] - Khurshid Jalal, Faisal Khan, Shazia Nawaz, Rushda Afroz, Kanwal Khan, Sadia Basharat Ali, Liangliang Hao, Saeed Ahmad Khan, Mohsin Kazi, Reaz Uddin, Darakhshan Jabeen Haleem. Anxiolytic, anti-nociceptive and body weight reducing effects of L-lysine in rats: Relationship with brain serotonin an In-Vivo and In-Silico study.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2022 Aug; 152(?):113235. doi:
10.1016/j.biopha.2022.113235
. [PMID: 35696944] - Ying Shen, Xia Luo, Qing Guan, Liming Cheng. Development, validation and standardization of urinary 5-hydroxyindoleacetic acid determination by LC-MS/MS for implementation in quality-controlled environments.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2022 Jul; 1203(?):123315. doi:
10.1016/j.jchromb.2022.123315
. [PMID: 35665645] - David Calderón Guzmán, Norma Osnaya Brizuela, Maribel Ortiz Herrera, Hugo Juárez Olguín, Quetzalli Veloz Corona, Lulu Sanchez Reyes, Armando Valenzuela Peraza, Gerardo Barragán Mejía. Oseltamivir induces favorable response on oxidative damage in the brain of rats treated with Bezafibrate.
The International journal of neuroscience.
2022 Jun; 132(6):574-581. doi:
10.1080/00207454.2020.1828882
. [PMID: 32976735] - Nadeem, Shumaila Usman, Rehan Imad, Uzair Nisar, Irfan Khan, Ghulam Abbas. Pre-weaning fluoxetine exposure caused anti-depressant like behavior at adulthood via perturbing tryptophan metabolism in rats.
Metabolic brain disease.
2022 06; 37(5):1415-1422. doi:
10.1007/s11011-022-00951-4
. [PMID: 35303245] - Qiufen Li, Hua Zhou, Jingxin Ouyang, Shuaipeng Guo, Jun Zheng, Guanhong Li. Effects of dietary tryptophan supplementation on body temperature, hormone, and cytokine levels in broilers exposed to acute heat stress.
Tropical animal health and production.
2022 Apr; 54(3):164. doi:
10.1007/s11250-022-03161-3
. [PMID: 35435494] - Tim Meyer, Martyn Caplin, Mohid S Khan, Christos Toumpanakis, Shishir Shetty, John K Ramage, Aude Houchard, Kate Higgs, Tahir Shah. Circulating tumour cells and tumour biomarkers in functional midgut neuroendocrine tumours.
Journal of neuroendocrinology.
2022 04; 34(4):e13096. doi:
10.1111/jne.13096
. [PMID: 35132704] - Kateryna Murlanova, Netanela Cohen, Anna Pinkus, Liudmila Vinnikova, Mikhail Pletnikov, Michael Kirby, Jonathan Gorelick, Elyashiv Drori, Albert Pinhasov. Antidepressant-like effects of a chlorogenic acid- and cynarine-enriched fraction from Dittrichia viscosa root extract.
Scientific reports.
2022 03; 12(1):3647. doi:
10.1038/s41598-022-04840-9
. [PMID: 35256610] - Annelies Heylen, Yannick Vermeiren, Sophia E De Rooij, Rikie M Scholtens, Barbara C Van Munster, Debby Van Dam, Peter P De Deyn. Plasma 5-HIAA activity indicative of serotonergic disturbances in cognitively impaired, elderly patients experiencing postoperative delirium.
International journal of geriatric psychiatry.
2022 02; 37(2):. doi:
10.1002/gps.5677
. [PMID: 34985774] - Ashwani Sharma, Talever Singh, Devender Pathak, Tarun Virmani, Girish Kumar, Abdulsalam Alhalmi. Antidepressive-Like Effect of Aegle marmelos Leaf Extract in Chronic Unpredictable Mild Stress-Induced Depression-Like Behaviour in Rats.
BioMed research international.
2022; 2022(?):6479953. doi:
10.1155/2022/6479953
. [PMID: 36593774] - Jayoung Kim, Amanda De Hoedt, Emily Wiggins, Kelsey Haywood, Peng Jin, Bennett Greenwood, Niven R Narain, Vladimir Tolstikov, Valerie Bussberg, Kamil E Barbour, Michael A Kiebish, Stephen J Freedland, Jennifer T Anger. Diagnostic Utility of Serum and Urinary Metabolite Analysis in Patients with Interstitial Cystitis/Painful Bladder Syndrome.
Urology.
2021 11; 157(?):85-92. doi:
10.1016/j.urology.2021.05.005
. [PMID: 34010675] - Fatma Moncer, Nafaâ Adhoum, Darmin Catak, Lotfi Monser. Electrochemical sensor based on MIP for highly sensitive detection of 5-hydroxyindole-3-acetic acid carcinoid cancer biomarker in human biological fluids.
Analytica chimica acta.
2021 Oct; 1181(?):338925. doi:
10.1016/j.aca.2021.338925
. [PMID: 34556226] - Wouter T Zandee, Tessa Brabander, Anela Blažević, Noémie S Minczeles, Richard A Feelders, Wouter W de Herder, Johannes Hofland. Peptide Receptor Radionuclide Therapy With 177Lu-DOTATATE for Symptomatic Control of Refractory Carcinoid Syndrome.
The Journal of clinical endocrinology and metabolism.
2021 08; 106(9):e3665-e3672. doi:
10.1210/clinem/dgab289
. [PMID: 33942075] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040
. [PMID: 33910017] - Lierni Ugartemendia, Rafael Bravo, Martin Reuter, M Yolanda Castaño, Thomas Plieger, Vera Zamoscik, Peter Kirsch, Ana B Rodríguez. SLC6A4 polymorphisms modulate the efficacy of a tryptophan-enriched diet on age-related depression and social cognition.
Clinical nutrition (Edinburgh, Scotland).
2021 04; 40(4):1487-1494. doi:
10.1016/j.clnu.2021.02.023
. [PMID: 33743283] - Louis de Mestier, Frédérique Savagner, Hedia Brixi, Christine Do Cao, Sophie Dominguez-Tinajero, Guillaume Roquin, Bernard Goichot, Olivia Hentic, Olivier Dubreuil, Vincent Hautefeuille, Thomas Walter, Guillaume Cadiot. Plasmatic and Urinary 5-Hydroxyindolacetic Acid Measurements in Patients With Midgut Neuroendocrine Tumors: A GTE Study.
The Journal of clinical endocrinology and metabolism.
2021 03; 106(4):e1673-e1682. doi:
10.1210/clinem/dgaa924
. [PMID: 33382891] - Camille Monchaux De Oliveira, Line Pourtau, Sylvie Vancassel, Camille Pouchieu, Lucile Capuron, David Gaudout, Nathalie Castanon. Saffron Extract-Induced Improvement of Depressive-Like Behavior in Mice Is Associated with Modulation of Monoaminergic Neurotransmission.
Nutrients.
2021 Mar; 13(3):. doi:
10.3390/nu13030904
. [PMID: 33799507] - Philippe J Eugster, Catherine Centeno, Marielle Dunand, Caroline Seghezzi, Eric Grouzmann. Stabilization of urinary biogenic amines measured in clinical chemistry laboratories.
Clinica chimica acta; international journal of clinical chemistry.
2021 Mar; 514(?):24-28. doi:
10.1016/j.cca.2020.12.009
. [PMID: 33333038] - Karolina E Kolaczynska, Matthias E Liechti, Urs Duthaler. Development and validation of an LC-MS/MS method for the bioanalysis of psilocybin's main metabolites, psilocin and 4-hydroxyindole-3-acetic acid, in human plasma.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2021 Feb; 1164(?):122486. doi:
10.1016/j.jchromb.2020.122486
. [PMID: 33485158] - Jitendra Bajaj, Jaya Dwivedi, Ram Sahu, Vivek Dave, Kanika Verma, Sushil Joshi, Bhawana Sati, Swapnil Sharma, Veronique Seidel, Abhay Prakash Mishra. Antidepressant activity of Spathodea campanulata in mice and predictive affinity of spatheosides towards type A monoamine oxidase.
Cellular and molecular biology (Noisy-le-Grand, France).
2021 Jan; 67(1):1-8. doi:
10.14715/cmb/2021.67.1.1
. [PMID: 34817375] - Humberto V Frias, Cinthia Dos S Alves, Jorge C Flório, Eduardo F Bondan, Leoni V Bonamin, Cidéli P Coelho, Maria M Bernardi, Ivana B Suffredini. Vertical exposition to Luffa operculata extract deregulates behavior and hypothalamus neurotransmitters in juvenile rats.
Journal of ethnopharmacology.
2021 Jan; 264(?):113265. doi:
10.1016/j.jep.2020.113265
. [PMID: 32858198] - E E L Valente, J L Klotz, G Ahn, D L Harmon. Pattern of postruminal administration of l-tryptophan affects blood serotonin in cattle.
Domestic animal endocrinology.
2021 01; 74(?):106574. doi:
10.1016/j.domaniend.2020.106574
. [PMID: 33059121] - Estelle Ayme-Dietrich, Sylvia Da Silva, Ghina Alame Bouabout, Alizée Arnoux, Jérôme Guyonnet, Guillaume Becker, Laurent Monassier. Characterization of the spontaneous degenerative mitral valve disease in FVB mice.
PloS one.
2021; 16(9):e0257022. doi:
10.1371/journal.pone.0257022
. [PMID: 34473777] - Amy Buchanan-Hughes, Alex Pashley, Marion Feuilly, Florence Marteau, D Mark Pritchard, Simron Singh. Carcinoid Heart Disease: Prognostic Value of 5-Hydroxyindoleacetic Acid Levels and Impact on Survival: A Systematic Literature Review.
Neuroendocrinology.
2021; 111(1-2):1-15. doi:
10.1159/000506744
. [PMID: 32097914] - Amy G Aslamkhan, Qiuwei Xu, Amy Loughlin, Heather Vu, Stephen Pacchione, Bhavana Bhatt, Ivy Garfinkel, Tara Grady Styring, Lisa LaFranco-Scheuch, Kara Pearson, Spencer Reynolds, Nianyu Li, Heather Zhou, J Richard Miller, Nicolas Solban, Alan Bass, Warren E Glaab. Characterization of indoleamine-2,3-dioxygenase 1, tryptophan-2,3-dioxygenase, and Ido1/Tdo2 knockout mice.
Toxicology and applied pharmacology.
2020 11; 406(?):115216. doi:
10.1016/j.taap.2020.115216
. [PMID: 32871117] - Yue Zhang, Linfang Li, Ye Gao, Xinnan Wang, Lei Sun, Wei Ji, Yukihiro Ozaki. Nitrosonaphthol reaction-assisted SERS assay for selective determination of 5-hydroxyindole-3-acetic acid in human urine.
Analytica chimica acta.
2020 Oct; 1134(?):34-40. doi:
10.1016/j.aca.2020.08.020
. [PMID: 33059864] - Eun Jin Lee. Factors Predicting 6-Month Smoking Cessation in Korean Adults.
The Psychiatric quarterly.
2020 09; 91(3):703-714. doi:
10.1007/s11126-020-09730-9
. [PMID: 32157547] - Vandana Thakur, Sumit Jamwal, Mandeep Kumar, Vikrant Rahi, Puneet Kumar. Protective Effect of Hemin Against Experimental Chronic Fatigue Syndrome in Mice: Possible Role of Neurotransmitters.
Neurotoxicity research.
2020 Aug; 38(2):359-369. doi:
10.1007/s12640-020-00231-y
. [PMID: 32506340] - Catherine A Schweppe, Caitlin Burzynski, Subramaniam Jayanthi, Bruce Ladenheim, Jean Lud Cadet, Eliot L Gardner, Zheng-Xiong Xi, Henriette van Praag, Amy Hauck Newman, Thomas M Keck. Neurochemical and behavioral comparisons of contingent and non-contingent methamphetamine exposure following binge or yoked long-access self-administration paradigms.
Psychopharmacology.
2020 Jul; 237(7):1989-2005. doi:
10.1007/s00213-020-05513-z
. [PMID: 32388619] - Zebin Lin, Yuancheng Chen, Jiaolun Li, Zhiru Xu, Hao Wang, Junyi Lin, Xing Ye, Ziqin Zhao, Yiwen Shen, Yurong Zhang, Shuiqing Zheng, Yulan Rao. Pharmacokinetics of N-ethylpentylone and its effect on increasing levels of dopamine and serotonin in the nucleus accumbens of conscious rats.
Addiction biology.
2020 05; 25(3):e12755. doi:
10.1111/adb.12755
. [PMID: 30985062] - Tetsuya Shiga, Sho Horikoshi, Kazuko Kanno, Keiko Kanno-Nozaki, Masayuki Hikita, Shuntaro Itagaki, Itaru Miura, Hirooki Yabe. Plasma levels of dopamine metabolite correlate with mismatch negativity in patients with schizophrenia.
Psychiatry and clinical neurosciences.
2020 May; 74(5):289-293. doi:
10.1111/pcn.12984
. [PMID: 31994282] - Gilles Troché, Matthieu Henry-Lagarrigue, Frédérique Soppelsa, Stephane Legriel, Aihem Yehia, Fabrice Bruneel, Jean-Pierre Bédos, Odile Spreux-Varoquaux. Tryptophan pathway catabolites (serotonin, 5-hydroxyindolacetic acid, kynurenine) and enzymes (monoamine oxidase and indole amine 2,3 dioxygenase) in patients with septic shock: A prospective observational study versus healthy controls.
Medicine.
2020 May; 99(19):e19906. doi:
10.1097/md.0000000000019906
. [PMID: 32384433] - Kelly C Demarque, Ana C Dutra-Tavares, André L Nunes-Freitas, Ulisses C Araújo, Alex C Manhães, Yael Abreu-Villaça, Cláudio C Filgueiras, Anderson Ribeiro-Carvalho. Ethanol exposure during the brain growth spurt affects social behavior and increases susceptibility to acute ethanol effects during adolescence in male mice.
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience.
2020 May; 80(3):197-207. doi:
10.1002/jdn.10017
. [PMID: 32077124] - Sébastien Ferrari, Sonia Rey, Erik Høglund, Øyvind Øverli, Béatrice Chatain, Simon MacKenzie, Marie-Laure Bégout. Physiological responses during acute stress recovery depend on stress coping style in European sea bass, Dicentrarchus labrax.
Physiology & behavior.
2020 03; 216(?):112801. doi:
10.1016/j.physbeh.2020.112801
. [PMID: 31931036] - Csilla Egri, Mary Dunbar, Gabriella Ana Horvath. Correlation Between Salivary, Platelet and Central Serotonin Levels in Children.
The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques.
2020 03; 47(2):214-218. doi:
10.1017/cjn.2019.334
. [PMID: 31806056] - David Calderón Guzmán, Norma Osnaya Brizuela, Maribel Ortíz Herrera, Armando Valenzuela Peraza, Gerardo Barragán Mejía, Hugo Juárez Olguín, Francisca Trujillo Jiménez. Sildenafil alters biogenic amines and increases oxidative damage in brain regions of insulin-hypoglycemic rats.
Acta pharmaceutica (Zagreb, Croatia).
2020 Mar; 70(1):121-127. doi:
10.2478/acph-2020-0016
. [PMID: 31677373] - Aaron J Pandopulos, Cobus Gerber, Benjamin J Tscharke, Jake O'Brien, Jason M White, Richard Bade. A sensitive analytical method for the measurement of neurotransmitter metabolites as potential population biomarkers in wastewater.
Journal of chromatography. A.
2020 Feb; 1612(?):460623. doi:
10.1016/j.chroma.2019.460623
. [PMID: 31668998] - David Calderón Guzmán, Norma Osnaya Brizuela, Maribel Ortiz Herrera, Hugo Juárez Olguín, Armando Valenzuela Peraza, Ernestina Hernández García, Gerardo Barragán Mejía. Folic acid increases levels of GHS in brain of rats with oxidative stress induced with 3-nitropropionic acid.
Archives of physiology and biochemistry.
2020 Feb; 126(1):1-6. doi:
10.1080/13813455.2018.1484771
. [PMID: 30269600] - Alexander Baxter, Elizabeth K Wood, Christina S Barr, Daniel B Kay, Stephen J Suomi, J Dee Higley. Maternal neglect and the serotonin system are associated with daytime sleep in infant rhesus monkeys.
Development and psychopathology.
2020 02; 32(1):1-10. doi:
10.1017/s0954579418001359
. [PMID: 30712526] - Zi-Ao Huang, Kymora B Scotland, Yueyang Li, Jian-Ping Guo, Patrick L McGeer, Dirk Lange, David D Y Chen. Application of multisegment injection on quantification of creatinine and standard addition analysis of urinary 5-hydroxyindoleacetic acid simultaneously with creatinine normalization.
Electrophoresis.
2020 02; 41(3-4):183-193. doi:
10.1002/elps.201900456
. [PMID: 31850545] - Erik Höglund, Maria Moltesen, Maria Filipa Castanheira, Per-Ove Thörnqvist, Patricia I M Silva, Øyvind Øverli, Catarina Martins, Svante Winberg. Contrasting neurochemical and behavioral profiles reflects stress coping styles but not stress responsiveness in farmed gilthead seabream (Sparus aurata).
Physiology & behavior.
2020 02; 214(?):112759. doi:
10.1016/j.physbeh.2019.112759
. [PMID: 31785269] - Marloes Am Peters, Martijn van Faassen, Wilhelmina Ha de Jong, Grietje Bouma, Coby Meijer, Annemiek Me Walenkamp, Elisabeth Ge de Vries, Sjoukje F Oosting, Henricus G Ruhé, Ido P Kema. Use of selective serotonin reuptake inhibitors is associated with very low plasma-free serotonin concentrations in humans.
Annals of clinical biochemistry.
2020 01; 57(1):59-63. doi:
10.1177/0004563219880567
. [PMID: 31533444] - Debapriya Garabadu, Neha Srivastava, Yogesh Murti. Calotropis procera attenuates chronic unpredictable mild stress-induced depression in experimental animals.
Metabolic brain disease.
2019 12; 34(6):1635-1647. doi:
10.1007/s11011-019-00471-8
. [PMID: 31346860] - Paweł Gut, Marek Ruchała. Evaluation of 5-hydroxyindoloacetic acid excretion in urine in patients with small intestine neuroendocrine neoplasm and carcinoid syndrome treated with somatostatin analogues.
Neuro endocrinology letters.
2019 Dec; 40(7-8):315-318. doi:
. [PMID: 32304367]
- Martijn van Faassen, Grytsje Bouma, Lotte D de Hosson, Marloes A M Peters, Gursah Kats-Ugurlu, Elisabeth G E de Vries, Annemiek M E Walenkamp, Ido P Kema. Quantitative Profiling of Platelet-Rich Plasma Indole Markers by Direct-Matrix Derivatization Combined with LC-MS/MS in Patients with Neuroendocrine Tumors.
Clinical chemistry.
2019 11; 65(11):1388-1396. doi:
10.1373/clinchem.2019.305359
. [PMID: 31551315] - Takashi Sonobe, Tsuyoshi Akiyama, Cheng-Kun Du, James T Pearson. Serotonin uptake via plasma membrane monoamine transporter during myocardial ischemia-reperfusion in the rat heart in vivo.
Physiological reports.
2019 11; 7(22):e14297. doi:
10.14814/phy2.14297
. [PMID: 31782271] - Willem G van Ginkel, Danique van Vliet, Els van der Goot, Martijn H J R Faassen, Arndt Vogel, M Rebecca Heiner-Fokkema, Eddy A van der Zee, Francjan J van Spronsen. Blood and Brain Biochemistry and Behaviour in NTBC and Dietary Treated Tyrosinemia Type 1 Mice.
Nutrients.
2019 Oct; 11(10):. doi:
10.3390/nu11102486
. [PMID: 31623189] - Zhuo-Wei Gao, Rong-Le Ju, Min Luo, Shu-Lian Wu, Wen-Tong Zhang. The anxiolytic-like effects of ginsenoside Rg2 on an animal model of PTSD.
Psychiatry research.
2019 09; 279(?):130-137. doi:
10.1016/j.psychres.2018.12.034
. [PMID: 31103345] - Jana Janssens, Sawal D Atmosoerodjo, Yannick Vermeiren, Anthony R Absalom, Izaak den Daas, Peter P De Deyn. Sampling issues of cerebrospinal fluid and plasma monoamines: Investigation of the circadian rhythm and rostrocaudal concentration gradient.
Neurochemistry international.
2019 09; 128(?):154-162. doi:
10.1016/j.neuint.2019.04.015
. [PMID: 31034914] - L B Christiansen, S E Cremer, A Helander, Tine Madsen, M J Reimann, J E Møller, K Höglund, I Ljungvall, J Häggström, L H Olsen. Urine 5-hydroxyindoleacetic acid in Cavalier King Charles spaniels with preclinical myxomatous mitral valve disease.
Veterinary journal (London, England : 1997).
2019 Aug; 250(?):36-43. doi:
10.1016/j.tvjl.2019.06.005
. [PMID: 31383418] - Zhong-Hui Pu, Cheng Peng, Xiao-Fang Xie, Min Luo, Huan Zhu, Rui Feng, Liang Xiong. Alkaloids from the rhizomes of Ligusticum striatum exert antimigraine effects through regulating 5-HT1B receptor and c-Jun.
Journal of ethnopharmacology.
2019 Jun; 237(?):39-46. doi:
10.1016/j.jep.2019.03.026
. [PMID: 30880256] - Jana Vondroušová, Miloš Mikoška, Kamila Syslová, Adéla Böhmová, Hana Tejkalová, Lukáš Vacek, Petr Kodym, Daniel Krsek, Jiří Horáček. Monitoring of kynurenine pathway metabolites, neurotransmitters and their metabolites in blood plasma and brain tissue of individuals with latent toxoplasmosis.
Journal of pharmaceutical and biomedical analysis.
2019 Jun; 170(?):139-152. doi:
10.1016/j.jpba.2019.03.039
. [PMID: 30925271] - Martina Curto, Luana Lionetto, Francesco Fazio, Valentina Corigliano, Anna Comparelli, Stefano Ferracuti, Maurizio Simmaco, Ferdinando Nicoletti, Ross J Baldessarini. Serum xanthurenic acid levels: Reduced in subjects at ultra high risk for psychosis.
Schizophrenia research.
2019 06; 208(?):465-466. doi:
10.1016/j.schres.2019.02.020
. [PMID: 30837204] - Marcela Valko-Rokytovská, Beáta Hubková, Anna Birková, Jana Mašlanková, Marek Stupák, Marianna Zábavníková, Beáta Čižmárová, Mária Mareková. Specific Urinary Metabolites in Malignant Melanoma.
Medicina (Kaunas, Lithuania).
2019 May; 55(5):. doi:
10.3390/medicina55050145
. [PMID: 31100919] - Marianne E Pavel, Alexandria T Phan, Edward M Wolin, Beloo Mirakhur, Nilani Liyanage, Susan Pitman Lowenthal, George A Fisher, Aaron I Vinik. Effect of Lanreotide Depot/Autogel on Urinary 5-Hydroxyindoleacetic Acid and Plasma Chromogranin A Biomarkers in Nonfunctional Metastatic Enteropancreatic Neuroendocrine Tumors.
The oncologist.
2019 04; 24(4):463-474. doi:
10.1634/theoncologist.2018-0217
. [PMID: 30355775] - Maël Padelli, Clément Bruno, Julia Lemarchand, Patrick Vourc'h, Christian Andres, Hélène Blasco, Isabelle Benz-de Bretagne. [Determination of thresholds values for platelet serotonin and urinary 5-HIAA concentrations for the biological diagnosis of digestive neuroendocrine tumors].
Annales de biologie clinique.
2019 04; 77(2):161-168. doi:
10.1684/abc.2019.1432
. [PMID: 30998196] - T V Davydova, M A Gruden, V S Kudrin, V B Narkevich, L A Vetrile, I A Zakharova, R D E Sewell. Effect of Antibodies to Glutamate on Age-Related Memory Changes in C57Bl/6 Mice.
Bulletin of experimental biology and medicine.
2019 Jan; 166(3):326-329. doi:
10.1007/s10517-019-04343-0
. [PMID: 30627908] - Maria Michelle Papamichael, Charis Katsardis, Bircan Erbas, Catherine Itsiopoulos, Dimitris Tsoukalas. Urinary organic acids as biomarkers in the assessment of pulmonary function in children with asthma.
Nutrition research (New York, N.Y.).
2019 01; 61(?):31-40. doi:
10.1016/j.nutres.2018.10.004
. [PMID: 30683437] - Hikari Iba, Takuya Watanabe, Kanae Matsuzawa, Maki Saimiya, Masako Tanaka, Masaki Nagao, Hiroshi Moriyama, Kaori Kubota, Shutaro Katsurabayashi, Katsunori Iwasaki. Effect of Yokukansan and Yokukansankachimpihange on Aggressive Behavior, 5-HT Receptors and Arginine Vasopressin Expression in Social Isolation-Reared Mice.
Biological & pharmaceutical bulletin.
2019; 42(12):2009-2015. doi:
10.1248/bpb.b19-00499
. [PMID: 31787717] - Maurizio Pompili, Luana Lionetto, Martina Curto, Alberto Forte, Denise Erbuto, Franco Montebovi, Maria Elena Seretti, Isabella Berardelli, Gianluca Serafini, Marco Innamorati, Mario Amore, Ross J Baldessarini, Paolo Girardi, Maurizio Simmaco. Tryptophan and Kynurenine Metabolites: Are They Related to Depression?.
Neuropsychobiology.
2019; 77(1):23-28. doi:
10.1159/000491604
. [PMID: 30110684] - Dong-Sung Lee, Hee Geun Jo, Min Ji Kim, Hwan Lee, Sun Hee Cheong. Antioxidant and Anti-Stress Effects of Taurine Against Electric Foot-Shock-Induced Acute Stress in Rats.
Advances in experimental medicine and biology.
2019; 1155(?):185-196. doi:
10.1007/978-981-13-8023-5_17
. [PMID: 31468397] - Ting-Ting Du, Ting Cui, Hong-Mei Qiu, Nian-Ru Wang, Dan Huang, Xin-Hui Jiang. Simultaneous determination of tryptophan, kynurenine, kynurenic acid and two monoamines in rat plasma by HPLC-ECD/DAD.
Journal of pharmaceutical and biomedical analysis.
2018 Sep; 158(?):8-14. doi:
10.1016/j.jpba.2018.05.032
. [PMID: 29843007] - A S Davison, J A Harrold, G Hughes, B P Norman, J Devine, J Usher, A T Hughes, M Khedr, J A Gallagher, A M Milan, Halford J C G, L R Ranganath. Clinical and biochemical assessment of depressive symptoms in patients with Alkaptonuria before and after two years of treatment with nitisinone.
Molecular genetics and metabolism.
2018 09; 125(1-2):135-143. doi:
10.1016/j.ymgme.2018.07.008
. [PMID: 30049652] - Eric Grouzmann, Catherine Centeno, Philippe J Eugster. Quantification of vanillylmandelic acid, homovanillic acid and 5-hydroxyindoleacetic acid in urine using a dilute-and-shoot and ultra-high pressure liquid chromatography tandem mass spectrometry method.
Clinical chemistry and laboratory medicine.
2018 08; 56(9):1533-1541. doi:
10.1515/cclm-2017-1120
. [PMID: 29708876] - Amit Tirosh, Naris Nilubol, Dhaval Patel, Electron Kebebew. Prognostic Utility of 24-Hour Urinary 5-HIAA Doubling Time in Patients With Neuroendocrine Tumors.
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists.
2018 08; 24(8):710-717. doi:
10.4158/ep-2018-0022
. [PMID: 30084688] - Zhi-Kun Qiu, Jia-Li He, Xu Liu, Jia Zeng, Wei Xiao, Qing-Hong Fan, Xiao-Meng Chai, Wei-Hai Ye, Ji-Sheng Chen. Anxiolytic-like effects of paeoniflorin in an animal model of post traumatic stress disorder.
Metabolic brain disease.
2018 08; 33(4):1175-1185. doi:
10.1007/s11011-018-0216-4
. [PMID: 29633071] - David Calderón Guzmán, Norma Osnaya Brizuela, Maribel Ortiz Herrera, Hugo Juárez Olguín, Armando Valenzuela Peraza, Gerardo Barragán Mejía. β-Cyclodextrin and oleic acid increase levels of dopamine and potentiates oxidative damage in young and adult rat brain.
Lipids in health and disease.
2018 Jul; 17(1):172. doi:
10.1186/s12944-018-0816-3
. [PMID: 30045742] - Mikael Lindström, Niina Tohmola, Risto Renkonen, Esa Hämäläinen, Camilla Schalin-Jäntti, Outi Itkonen. Comparison of serum serotonin and serum 5-HIAA LC-MS/MS assays in the diagnosis of serotonin producing neuroendocrine neoplasms: A pilot study.
Clinica chimica acta; international journal of clinical chemistry.
2018 Jul; 482(?):78-83. doi:
10.1016/j.cca.2018.03.030
. [PMID: 29596816] - David L Chan, Matthew Dixon, Calvin H L Law, Serge Koujanian, Kaitlyn A Beyfuss, Simron Singh, Sten Myrehaug, Julie Hallet. Outcomes of Cytoreductive Surgery for Metastatic Low-Grade Neuroendocrine Tumors in the Setting of Extrahepatic Metastases.
Annals of surgical oncology.
2018 Jun; 25(6):1768-1774. doi:
10.1245/s10434-018-6433-6
. [PMID: 29560571] - Darakhshan M Saleem, Shafaque Mehboob, Moona Mehboob Khan, Noreen Samad, Afshan Zafar, Darakhshan J Haleem. Inhibition of diet-restriction-induced behavioral deficits by tryptophan administration in rats.
Pakistan journal of pharmaceutical sciences.
2018 May; 31(3(Supplementary)):1021-1029. doi:
NULL
. [PMID: 29731439] - Marianne Pavel, David J Gross, Marta Benavent, Petros Perros, Raj Srirajaskanthan, Richard R P Warner, Matthew H Kulke, Lowell B Anthony, Pamela L Kunz, Dieter Hörsch, Martin O Weickert, Pablo Lapuerta, Wenjun Jiang, Kenneth Kassler-Taub, Suman Wason, Rosanna Fleming, Douglas Fleming, Rocio Garcia-Carbonero. Telotristat ethyl in carcinoid syndrome: safety and efficacy in the TELECAST phase 3 trial.
Endocrine-related cancer.
2018 03; 25(3):309-322. doi:
10.1530/erc-17-0455
. [PMID: 29330194] - Alexandra R Lewis, Xin Wang, Laurice Magdalani, Paolo D'Arienzo, Colsom Bashir, Was Mansoor, Richard Hubner, Juan W Valle, Mairéad G McNamara. Health-related quality of life, anxiety, depression and impulsivity in patients with advanced gastroenteropancreatic neuroendocrine tumours.
World journal of gastroenterology.
2018 Feb; 24(6):671-679. doi:
10.3748/wjg.v24.i6.671
. [PMID: 29456406] - Ernestina Hernández García, Norma Osnaya Brizuela, Armando Valenzuela Peraza, David Calderón Guzmán, Maribel Ortiz Herrera, Hugo Juárez Olguín, Gerardo Barragán Mejía, Daniel Santamaría Del Ángel, Alberto Rojas Ochoa. Biochemical and histological changes produced by sweeteners and cytarabine in the brain of young rats.
Nutricion hospitalaria.
2018 Feb; 35(1):194-200. doi:
10.20960/nh.1245
. [PMID: 29565169] - Víctor Rodríguez Laval, Marianne Pavel, Ingo G Steffen, Alexander D Baur, Lisa M Dilz, Christian Fischer, Katharina Detjen, Vikas Prasad, Andreas Pascher, Dominik Geisel, Timm Denecke. Mesenteric Fibrosis in Midgut Neuroendocrine Tumors: Functionality and Radiological Features.
Neuroendocrinology.
2018; 106(2):139-147. doi:
10.1159/000474941
. [PMID: 28384635] - Andrea Michelerio, Federica Derlino, Valeria Brazzelli, Camilla Vassallo. Secondary erythromelalgia: a tryptophan dietary supplement-induced case associated with elevated 5-hydroxyindoleacetic acid (5HIAA) urinary levels.
International journal of dermatology.
2018 Jan; 57(1):83-85. doi:
10.1111/ijd.13760
. [PMID: 29152720] - Sygrid van der Zee, Yannick Vermeiren, Erik Fransen, Debby Van Dam, Tony Aerts, Marleen J Gerritsen, Jacoba M Spikman, Teus van Laar, Peter P De Deyn. Monoaminergic Markers Across the Cognitive Spectrum of Lewy Body Disease.
Journal of Parkinson's disease.
2018; 8(1):71-84. doi:
10.3233/jpd-171228
. [PMID: 29480224] - Maria C Cartolano, Molly H B Amador, Velislava Tzaneva, William K Milsom, M Danielle McDonald. Extrinsic nerves are not involved in branchial 5-HT dynamics or pulsatile urea excretion in Gulf toadfish, Opsanus beta.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
2017 12; 214(?):58-65. doi:
10.1016/j.cbpa.2017.08.009
. [PMID: 28887162] - Claudia Francesca Gasparini, Robert Anthony Smith, Lyn Robyn Griffiths. Genetic and biochemical changes of the serotonergic system in migraine pathobiology.
The journal of headache and pain.
2017 Dec; 18(1):20. doi:
10.1186/s10194-016-0711-0
. [PMID: 28194570] - David Calderón Guzmán, Maribel Ortiz Herrera, Norma Osnaya Brizuela, Gerardo Barragán Mejía, Hugo Juárez Olguín, Armando Valenzuela Peraza. Trace elements cause oxidative damage in the brain of rats with induced hypotension.
Autonomic neuroscience : basic & clinical.
2017 12; 208(?):113-116. doi:
10.1016/j.autneu.2017.11.001
. [PMID: 29158115] - Clarissa M D Mota, Caroline Rodrigues-Santos, Rodrigo A R Fernández, Ruither O G Carolino, José Antunes-Rodrigues, Janete A Anselmo-Franci, Luiz G S Branco. Central serotonin attenuates LPS-induced systemic inflammation.
Brain, behavior, and immunity.
2017 Nov; 66(?):372-381. doi:
10.1016/j.bbi.2017.07.010
. [PMID: 28723348] - Marco A Vindas, Angelico Madaro, Thomas W K Fraser, Erik Höglund, Rolf E Olsen, Tore S Kristiansen, Øyvind Øverli. Uncontrollable chronic stress reduces growth disparities in farmed Atlantic salmon.
Physiology & behavior.
2017 Oct; 179(?):246-252. doi:
10.1016/j.physbeh.2017.06.012
. [PMID: 28668622] - Jie Liu, Yue-Wei Lv, Jin-Li Shi, Xiao-Jie Ma, Yi Chen, Zhi-Quan Zheng, Sheng-Nan Wang, Jian-You Guo. Anti-Anxiety Effect of (-)-Syringaresnol-4-O-β-d-apiofuranosyl-(1→2)-β-d-glucopyranoside from Albizzia julibrissin Durazz (Leguminosae).
Molecules (Basel, Switzerland).
2017 Aug; 22(8):. doi:
10.3390/molecules22081331
. [PMID: 28800105] - Jolanta Soltysiak, Danuta Ostalska-Nowicka, Katarzyna Zaorska, Karolina Sterzyńska, Katarzyna Derwich, Jacek Zachwieja. Atypical thymic carcinoid manifesting with nephrotic-range proteinuria in a 7-year-old boy.
Pediatric nephrology (Berlin, Germany).
2017 Aug; 32(8):1465-1468. doi:
10.1007/s00467-017-3685-5
. [PMID: 28477260] - Nico Johan Badenhorst, Linda Brand, Brian Herbert Harvey, Susanna Maria Ellis, Christiaan Beyers Brink. Long-term effects of pre-pubertal fluoxetine on behaviour and monoaminergic stress response in stress-sensitive rats.
Acta neuropsychiatrica.
2017 Aug; 29(4):222-235. doi:
10.1017/neu.2016.53
. [PMID: 27819195] - Robin L Haynes, Andrew L Frelinger, Emma K Giles, Richard D Goldstein, Hoa Tran, Harry P Kozakewich, Elisabeth A Haas, Anja J Gerrits, Othon J Mena, Felicia L Trachtenberg, David S Paterson, Gerard T Berry, Khosrow Adeli, Hannah C Kinney, Alan D Michelson. High serum serotonin in sudden infant death syndrome.
Proceedings of the National Academy of Sciences of the United States of America.
2017 07; 114(29):7695-7700. doi:
10.1073/pnas.1617374114
. [PMID: 28674018] - Diana D Shi, David P Yuppa, Trevor Dutton, Lauren K Brais, Sarah L Minden, Ilana M Braun, Matthew H Kulke, Jennifer A Chan, Fremonta L Meyer. Retrospective review of serotonergic medication tolerability in patients with neuroendocrine tumors with biochemically proven carcinoid syndrome.
Cancer.
2017 Jul; 123(14):2735-2742. doi:
10.1002/cncr.30633
. [PMID: 28267211] - Ekaterina Y Bazhenova, Nadezhda A Sinyakova, Elizabeth A Kulikova, Irina A Kazarinova, Daria V Bazovkina, Raul R Gainetdinov, Alexander V Kulikov. No effect of C1473G polymorphism in the tryptophan hydroxylase 2 gene on the response of the brain serotonin system to chronic fluoxetine treatment in mice.
Neuroscience letters.
2017 Jul; 653(?):264-268. doi:
10.1016/j.neulet.2017.05.070
. [PMID: 28579486] - Amanda Eskelund, Yan Li, David P Budac, Heidi K Müller, Maria Gulinello, Connie Sanchez, Gregers Wegener. Drugs with antidepressant properties affect tryptophan metabolites differently in rodent models with depression-like behavior.
Journal of neurochemistry.
2017 07; 142(1):118-131. doi:
10.1111/jnc.14043
. [PMID: 28407315] - Sang Gyun Jin, Min Jung Kim, So Young Park, Shi Nae Park. Stress hormonal changes in the brain and plasma after acute noise exposure in mice.
Auris, nasus, larynx.
2017 Jun; 44(3):272-276. doi:
10.1016/j.anl.2016.07.013
. [PMID: 27496010] - Zhandong Liu, Yanjue Wu, Tianhui Liu, Ren Li, Minhao Xie. Serotonin regulation in a rat model of exercise-induced chronic fatigue.
Neuroscience.
2017 05; 349(?):27-34. doi:
10.1016/j.neuroscience.2017.02.037
. [PMID: 28257895] - David L Chan, Stephen J Clarke, Connie I Diakos, Paul J Roach, Dale L Bailey, Simron Singh, Nick Pavlakis. Prognostic and predictive biomarkers in neuroendocrine tumours.
Critical reviews in oncology/hematology.
2017 May; 113(?):268-282. doi:
10.1016/j.critrevonc.2017.03.017
. [PMID: 28427516] - Amit Tirosh, Georgios Z Papadakis, Corina Millo, Samira M Sadowski, Peter Herscovitch, Karel Pacak, Stephen J Marx, Lily Yang, Pavel Nockel, Jasmine Shell, Patience Green, Xavier M Keutgen, Dhaval Patel, Naris Nilubol, Electron Kebebew. Association between neuroendocrine tumors biomarkers and primary tumor site and disease type based on total 68Ga-DOTATATE-Avid tumor volume measurements.
European journal of endocrinology.
2017 May; 176(5):575-582. doi:
10.1530/eje-16-1079
. [PMID: 28289088]