Deoxyuridine (BioDeep_00000001208)

 

Secondary id: BioDeep_00000400047, BioDeep_00000406190, BioDeep_00000865344

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite BioNovoGene_Lab2019


代谢物信息卡片


1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione

化学式: C9H12N2O5 (228.0746)
中文名称: 2'-脱氧尿苷, 脱氧尿苷
谱图信息: 最多检出来源 Homo sapiens(blood) 18.72%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

Deoxyuridine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/2_-deoxyuridine (retrieved 2024-12-22) (BioDeep RN: BioDeep_00000001208). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1C(C(OC1N2C=CC(=O)NC2=O)CO)O
InChI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)

描述信息

Deoxyuridine, also known as dU, belongs to the class of organic compounds known as pyrimidine 2-deoxyribonucleosides. Pyrimidine 2-deoxyribonucleosides are compounds consisting of a pyrimidine linked to a ribose which lacks a hydroxyl group at position 2. It is similar in chemical structure to uridine, but without the 2-hydroxyl group. Deoxyuridine exists in all living organisms, ranging from bacteria to humans. Within humans, deoxyuridine participates in a number of enzymatic reactions. In particular, deoxyuridine can be biosynthesized from deoxycytidine through its interaction with the enzyme cytidine deaminase. In addition, deoxyuridine can be converted into uracil and deoxyribose 1-phosphate through its interaction with the enzyme thymidine phosphorylase. Deoxyuridine is considered to be an antimetabolite that is converted into deoxyuridine triphosphate during DNA synthesis. Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemia due to vitamin B12 and folate deficiencies. In humans, deoxyuridine is involved in the metabolic disorder called UMP synthase deficiency (orotic aciduria). Outside of the human body, deoxyuridine has been detected, but not quantified in, several different foods, such as lichee, highbush blueberries, agaves, macadamia nut (M. tetraphylla), and red bell peppers. This could make deoxyuridine a potential biomarker for the consumption of these foods.
2-Deoxyuridine is a naturally occurring nucleoside. It is similar in chemical structure to uridine, but without the 2-hydroxyl group. It is considered to be an antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemia due to vitamin B12 and folate deficiencies. [HMDB]. Deoxyuridine is found in many foods, some of which are garden tomato (variety), hickory nut, banana, and hazelnut.

Deoxyuridine. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=951-78-0 (retrieved 2024-07-01) (CAS RN: 951-78-0). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine.
2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine.
2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine.

同义名列表

22 个代谢物同义名

1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione; 1-(2-Deoxy-beta-delta-erythro-pentofuranosyl)-2,4(1H,3H)-pyrimidinedione; 1-(2-Deoxy-beta-D-erythro-pentofuranosyl)-2,4(1H,3H)-pyrimidinedione; 1-(2-Deoxy-beta-delta-ribofuranosyl)-2,4(1H,3H)-pyrimidinedione; 1-(2-Deoxy-beta-D-ribofuranosyl)-2,4(1H,3H)-pyrimidinedione; 1-(2-Deoxy-delta-erythro-pentofuranosyl)uracil; 1-(2-Deoxy-D-erythro-pentofuranosyl)uracil; (beta 1-(2-Deoxyribopyranosyl))thymidine; 2-Deoxyuridine-13C,15N2; Uracil desoxyuridine; Uracil deoxyriboside; (+)-2-Deoxyuridine; Deoxyribose uracil; 2-Desoxyuridine; 2-deoxyuridine; 2-Deoxyuridine; Desoxyuridine; Deoxyuridine; dU; Deoxyuridine; 2'-Deoxyuridine; Deoxyuridine



数据库引用编号

28 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(5)

PlantCyc(0)

代谢反应

374 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(95)

WikiPathways(2)

Plant Reactome(0)

INOH(2)

PlantCyc(253)

COVID-19 Disease Map(1)

PathBank(21)

PharmGKB(0)

11 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 APOBEC3G, BCL2, CASP3, DCK, DCTD, DHFR, ENDOV, PMP2, PNP, TK2, TYMS
Endoplasmic reticulum membrane 1 BCL2
Nucleus 10 APOBEC3G, BCL2, CASP3, DCK, DUT, LIG4, PMP2, TK1, TYMS, UNG
cytosol 13 APOBEC3G, BCL2, CASP3, CDA, DCK, DCTD, DHFR, PMP2, PNP, TK1, TYMP, TYMS, UPP1
nucleoplasm 6 CASP3, DCK, DUT, LIG4, UNG, UPP1
cell surface 1 EPO
glutamatergic synapse 1 CASP3
mitochondrial inner membrane 1 TYMS
neuronal cell body 1 CASP3
plasma membrane 1 TCN2
Membrane 1 BCL2
extracellular exosome 4 DUT, EPO, PMP2, PNP
endoplasmic reticulum 1 BCL2
extracellular space 3 EPO, PNP, TCN2
lysosomal lumen 1 TCN2
mitochondrion 7 BCL2, DCK, DHFR, DUT, TK2, TYMS, UNG
protein-containing complex 1 BCL2
intracellular membrane-bounded organelle 1 LIG4
postsynaptic density 1 CASP3
Secreted 3 EPO, PNP, TCN2
extracellular region 4 CDA, EPO, PNP, TCN2
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
Mitochondrion matrix 1 TYMS
mitochondrial matrix 2 TK2, TYMS
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 1 TCN2
nucleolus 1 ENDOV
Cytoplasm, P-body 1 APOBEC3G
P-body 1 APOBEC3G
Mitochondrion inner membrane 1 TYMS
pore complex 1 BCL2
apolipoprotein B mRNA editing enzyme complex 1 APOBEC3G
Nucleus, nucleolus 1 ENDOV
chromosome, telomeric region 1 LIG4
Cytoplasm, Stress granule 1 ENDOV
cytoplasmic stress granule 1 ENDOV
cell body 1 EPO
myelin sheath 2 BCL2, PMP2
[Isoform 1]: Cytoplasm 1 ENDOV
ficolin-1-rich granule lumen 2 CDA, PNP
secretory granule lumen 3 CDA, EPO, PNP
tertiary granule lumen 1 CDA
ribonucleoprotein complex 1 APOBEC3G
[Isoform 2]: Nucleus 1 DUT
death-inducing signaling complex 1 CASP3
condensed chromosome 1 LIG4
[Isoform 3]: Mitochondrion 1 DUT
[Isoform 7]: Cytoplasm 1 ENDOV
BAD-BCL-2 complex 1 BCL2
[Isoform 6]: Cytoplasm 1 ENDOV
DNA-dependent protein kinase-DNA ligase 4 complex 1 LIG4
nonhomologous end joining complex 1 LIG4
DNA ligase IV complex 1 LIG4


文献列表

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