2'-deoxyuridine (BioDeep_00000001208)

 

Secondary id: BioDeep_00000400047, BioDeep_00000406190, BioDeep_00000865344

natural product human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite


代谢物信息卡片


1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione

化学式: C9H12N2O5 (228.07461819999997)
中文名称: 2’-脱氧尿苷
谱图信息: 最多检出来源 Homo sapiens(blood) 0.04%

Reviewed

Last reviewed on 2024-09-13.

Cite this Page

2'-deoxyuridine. BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China. https://query.biodeep.cn/s/2_-deoxyuridine (retrieved 2024-09-17) (BioDeep RN: BioDeep_00000001208). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).

分子结构信息

SMILES: C1C(C(OC1N2C=CC(=O)NC2=O)CO)O
InChI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)

描述信息

Deoxyuridine, also known as dU, belongs to the class of organic compounds known as pyrimidine 2-deoxyribonucleosides. Pyrimidine 2-deoxyribonucleosides are compounds consisting of a pyrimidine linked to a ribose which lacks a hydroxyl group at position 2. It is similar in chemical structure to uridine, but without the 2-hydroxyl group. Deoxyuridine exists in all living organisms, ranging from bacteria to humans. Within humans, deoxyuridine participates in a number of enzymatic reactions. In particular, deoxyuridine can be biosynthesized from deoxycytidine through its interaction with the enzyme cytidine deaminase. In addition, deoxyuridine can be converted into uracil and deoxyribose 1-phosphate through its interaction with the enzyme thymidine phosphorylase. Deoxyuridine is considered to be an antimetabolite that is converted into deoxyuridine triphosphate during DNA synthesis. Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemia due to vitamin B12 and folate deficiencies. In humans, deoxyuridine is involved in the metabolic disorder called UMP synthase deficiency (orotic aciduria). Outside of the human body, deoxyuridine has been detected, but not quantified in, several different foods, such as lichee, highbush blueberries, agaves, macadamia nut (M. tetraphylla), and red bell peppers. This could make deoxyuridine a potential biomarker for the consumption of these foods.
2-Deoxyuridine is a naturally occurring nucleoside. It is similar in chemical structure to uridine, but without the 2-hydroxyl group. It is considered to be an antimetabolite that is converted to deoxyuridine triphosphate during DNA synthesis. Laboratory suppression of deoxyuridine is used to diagnose megaloblastic anemia due to vitamin B12 and folate deficiencies. [HMDB]. Deoxyuridine is found in many foods, some of which are garden tomato (variety), hickory nut, banana, and hazelnut.

Deoxyuridine. CAS Common Chemistry. CAS, a division of the American Chemical Society, n.d. https://commonchemistry.cas.org/detail?cas_rn=951-78-0 (retrieved 2024-07-01) (CAS RN: 951-78-0). Licensed under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine.
2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine.
2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine.

同义名列表

21 个代谢物同义名

1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2,3,4-tetrahydropyrimidine-2,4-dione; 1-(2-Deoxy-beta-delta-erythro-pentofuranosyl)-2,4(1H,3H)-pyrimidinedione; 1-(2-Deoxy-beta-D-erythro-pentofuranosyl)-2,4(1H,3H)-pyrimidinedione; 1-(2-Deoxy-beta-delta-ribofuranosyl)-2,4(1H,3H)-pyrimidinedione; 1-(2-Deoxy-beta-D-ribofuranosyl)-2,4(1H,3H)-pyrimidinedione; 1-(2-Deoxy-delta-erythro-pentofuranosyl)uracil; 1-(2-Deoxy-D-erythro-pentofuranosyl)uracil; (beta 1-(2-Deoxyribopyranosyl))thymidine; 2-Deoxyuridine-13C,15N2; Uracil desoxyuridine; Uracil deoxyriboside; (+)-2-Deoxyuridine; Deoxyribose uracil; 2-Desoxyuridine; 2-deoxyuridine; 2-Deoxyuridine; Desoxyuridine; Deoxyuridine; dU; Deoxyuridine; 2'-Deoxyuridine



数据库引用编号

25 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(5)

PlantCyc(0)

代谢反应

374 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(95)

WikiPathways(2)

Plant Reactome(0)

INOH(2)

PlantCyc(253)

COVID-19 Disease Map(1)

PathBank(21)

PharmGKB(0)

21 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Peihua Gan, Peiling Li, Xiaolin Zhang, Hailin Li, Shaojie Ma, Dan Zong, Chengzhong He. Comparative Transcriptomic and Metabolomic Analyses of Differences in Trunk Spiral Grain in Pinus yunnanensis. International journal of molecular sciences. 2023 Sep; 24(19):. doi: 10.3390/ijms241914658. [PMID: 37834105]
  • Junjie Yang, Jiayu Liu, Jing Li, Ming Jing, Leiming Zhang, Mengmeng Sun, Qiaoyun Wang, Hongliu Sun, Guige Hou, Chunhua Wang, Wenyu Xin. Celastrol inhibits rheumatoid arthritis by inducing autophagy via inhibition of the PI3K/AKT/mTOR signaling pathway. International immunopharmacology. 2022 Nov; 112(?):109241. doi: 10.1016/j.intimp.2022.109241. [PMID: 36116150]
  • Yang Jiang, Junshuang Zhao, Rongqing Li, Yingliang Liu, Lin Zhou, Chengbin Wang, Caihong Lv, Liang Gao, Daming Cui. CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis. Journal of experimental & clinical cancer research : CR. 2022 Oct; 41(1):307. doi: 10.1186/s13046-022-02518-8. [PMID: 36266731]
  • Markus Niehaus, Henryk Straube, André Specht, Chiara Baccolini, Claus-Peter Witte, Marco Herde. The nucleotide metabolome of germinating Arabidopsis thaliana seeds reveals a central role for thymidine phosphorylation in chloroplast development. The Plant cell. 2022 09; 34(10):3790-3813. doi: 10.1093/plcell/koac207. [PMID: 35861422]
  • Aleksandra Skalska-Bugala, Marta Starczak, Łukasz Szukalski, Maciej Gawronski, Agnieszka Siomek-Gorecka, Justyna Szpotan, Anna Labejszo, Ewelina Zarakowska, Anna Szpila, Anna Jachalska, Adriana Szukalska, Marcin Kruszewski, Anna Sadowska, Aleksandra Wasilow, Patrycja Baginska, Jaroslaw Czyz, Ryszard Olinski, Rafal Rozalski, Daniel Gackowski. Diagnostic and Prognostic Power of Active DNA Demethylation Pathway Intermediates in Acute Myelogenous Leukemia and Myelodysplastic Syndromes. Cells. 2022 03; 11(5):. doi: 10.3390/cells11050888. [PMID: 35269510]
  • Dmitry I Maltsev, Kennelia A Mellanson, Vsevolod V Belousov, Grigori N Enikolopov, Oleg V Podgorny. The bioavailability time of commonly used thymidine analogues after intraperitoneal delivery in mice: labeling kinetics in vivo and clearance from blood serum. Histochemistry and cell biology. 2022 Feb; 157(2):239-250. doi: 10.1007/s00418-021-02048-y. [PMID: 34757474]
  • Michael D Waters, Stafford Warren, Claude Hughes, Philip Lewis, Fengyu Zhang. Human genetic risk of treatment with antiviral nucleoside analog drugs that induce lethal mutagenesis: The special case of molnupiravir. Environmental and molecular mutagenesis. 2022 01; 63(1):37-63. doi: 10.1002/em.22471. [PMID: 35023215]
  • Prateek Srivastava, Ankush Paladhi, Ranjeet Singh, Divesh Narayan Srivastava, Ram Adhar Singh, Sumit Kumar Hira, Partha Pratim Manna. Targeting PD-1 in CD8+ T Cells with a Biomimetic Bilirubin-5-fluoro-2-deoxyuridine-Bovine Serum Albumin Nanoconstruct for Effective Chemotherapy against Experimental Lymphoma. Molecular pharmaceutics. 2021 05; 18(5):2053-2065. doi: 10.1021/acs.molpharmaceut.1c00050. [PMID: 33886324]
  • Nadhiratul-Farihin Semail, Siti Salmah Noordin, Aemi Syazwani Abdul Keyon, Maisarah Nasution Waras, Bahruddin Saad, Sazlinda Kamaruzaman, Nur Nadhirah Mohamad Zain, Juzaili Azizi, Mohd Yusmaidie Aziz, Noorfatimah Yahaya. A simple and efficient sequential electrokinetic and hydrodynamic injections in micellar electrokinetic chromatography method for quantification of anticancer drug 5-fluorouracil and its metabolite in human plasma. Biomedical chromatography : BMC. 2021 May; 35(5):e5050. doi: 10.1002/bmc.5050. [PMID: 33314228]
  • Hirotomo Takatsuka, Masaaki Umeda. Whole-Mount Immunostaining for the Identification of Histone Modifications in the S-Phase Nuclei of Arabidopsis Roots. Methods in molecular biology (Clifton, N.J.). 2021; 2329(?):71-80. doi: 10.1007/978-1-0716-1538-6_6. [PMID: 34085216]
  • Helena Taflin, Elisabeth Odin, Göran Carlsson, Roger Tell, Bengt Gustavsson, Yvonne Wettergren. Plasma deoxyuridine as a surrogate marker for toxicity and early clinical response in patients with metastatic colorectal cancer after 5-FU-based therapy in combination with arfolitixorin. Cancer chemotherapy and pharmacology. 2021 01; 87(1):31-41. doi: 10.1007/s00280-020-04173-2. [PMID: 33099678]
  • Emily E Wear, Jawon Song, Gregory J Zynda, Leigh Mickelson-Young, Chantal LeBlanc, Tae-Jin Lee, David O Deppong, George C Allen, Robert A Martienssen, Matthew W Vaughn, Linda Hanley-Bowdoin, William F Thompson. Comparing DNA replication programs reveals large timing shifts at centromeres of endocycling cells in maize roots. PLoS genetics. 2020 10; 16(10):e1008623. doi: 10.1371/journal.pgen.1008623. [PMID: 33052904]
  • Cancan Yang, Jing Li, Zhenling Huang, Xuefa Zhang, Xiaolei Gao, Chunyuang Zhu, Paul F Morris, XiuGuo Zhang. Structural and catalytic analysis of two diverse uridine phosphorylases in Phytophthora capsici. Scientific reports. 2020 06; 10(1):9051. doi: 10.1038/s41598-020-65935-9. [PMID: 32493959]
  • Jonatan Darr, Archana Tomar, Maximilian Lassi, Raffaele Gerlini, Lucia Berti, Annette Hering, Fabienne Scheid, Martin Hrabě de Angelis, Michael Witting, Raffaele Teperino. iTAG-RNA Isolates Cell-Specific Transcriptional Responses to Environmental Stimuli and Identifies an RNA-Based Endocrine Axis. Cell reports. 2020 03; 30(9):3183-3194.e4. doi: 10.1016/j.celrep.2020.02.020. [PMID: 32130917]
  • Rieko Fujinami. Analysis of Cell Division Frequency in the Root Apical Meristem of Lycophytes, Non-seed Vascular Plants, Using EdU Labeling. Methods in molecular biology (Clifton, N.J.). 2020; 2094(?):91-99. doi: 10.1007/978-1-0716-0183-9_10. [PMID: 31797294]
  • Ravi Patel, Lucia Lee Coulter, Joanna Rimmer, Miles Parkes, Patrick Francis Chinnery, Oscar Swift. Mitochondrial neurogastrointestinal encephalopathy: a clinicopathological mimic of Crohn's disease. BMC gastroenterology. 2019 Jan; 19(1):11. doi: 10.1186/s12876-018-0925-5. [PMID: 30646848]
  • Xiaoting Shu, Menghao Liu, Zhike Lu, Chenxu Zhu, Haowei Meng, Sihao Huang, Xiaoxue Zhang, Chengqi Yi. Genome-wide mapping reveals that deoxyuridine is enriched in the human centromeric DNA. Nature chemical biology. 2018 07; 14(7):680-687. doi: 10.1038/s41589-018-0065-9. [PMID: 29785056]
  • Chloé Michel, Rita Küchler, Iris Martin, Bruno Kyewski, Sheena Pinto. An efficient protocol for in vivo labeling of proliferating epithelial cells. Journal of immunological methods. 2018 06; 457(?):82-86. doi: 10.1016/j.jim.2018.03.015. [PMID: 29605230]
  • Jolanta Kwasniewska, Karolina Zubrzycka, Arita Kus. Impact of Mutagens on DNA Replication in Barley Chromosomes. International journal of molecular sciences. 2018 Apr; 19(4):. doi: 10.3390/ijms19041070. [PMID: 29614057]
  • Martina Dvořáčková, Berta Raposo, Petr Matula, Joerg Fuchs, Veit Schubert, Vratislav Peška, Bénédicte Desvoyes, Crisanto Gutierrez, Jiří Fajkus. Replication of ribosomal DNA in Arabidopsis occurs both inside and outside the nucleolus during S phase progression. Journal of cell science. 2018 01; 131(2):. doi: 10.1242/jcs.202416. [PMID: 28483825]
  • I F Usynin, A N Dudarev, A Yu Gorodetskaya, S M Miroshnichenko, T A Tkachenko, V I Tkachenko. Apolipoprotein A-I Stimulates Cell Proliferation in Bone Marrow Cell Culture. Bulletin of experimental biology and medicine. 2018 Jan; 164(3):308-311. doi: 10.1007/s10517-018-3978-0. [PMID: 29313227]
  • Michelle Levene, Francisco J Enguita, Bridget E Bax. Discovery profiling and bioinformatics analysis of serum microRNA in Mitochondrial NeuroGastroIntestinal Encephalomyopathy (MNGIE). Nucleosides, nucleotides & nucleic acids. 2018; 37(11):618-629. doi: 10.1080/15257770.2018.1492138. [PMID: 30587073]
  • Benjamin Röeben, Justus Marquetand, Benjamin Bender, Heiko Billing, Tobias B Haack, Iciar Sanchez-Albisua, Ludger Schöls, Henk J Blom, Matthis Synofzik. Hemodialysis in MNGIE transiently reduces serum and urine levels of thymidine and deoxyuridine, but not CSF levels and neurological function. Orphanet journal of rare diseases. 2017 08; 12(1):135. doi: 10.1186/s13023-017-0687-0. [PMID: 28764801]
  • Aleem Syed, Emily A Smith. Raman Imaging in Cell Membranes, Lipid-Rich Organelles, and Lipid Bilayers. Annual review of analytical chemistry (Palo Alto, Calif.). 2017 06; 10(1):271-291. doi: 10.1146/annurev-anchem-061516-045317. [PMID: 28301746]
  • Waleed A Hassanain, Emad L Izake, Arumugam Sivanesan, Godwin A Ayoko. Towards interference free HPLC-SERS for the trace analysis of drug metabolites in biological fluids. Journal of pharmaceutical and biomedical analysis. 2017 Mar; 136(?):38-43. doi: 10.1016/j.jpba.2016.12.019. [PMID: 28063334]
  • Leigh Mickelson-Young, Emily Wear, Patrick Mulvaney, Tae-Jin Lee, Eric S Szymanski, George Allen, Linda Hanley-Bowdoin, William Thompson. A flow cytometric method for estimating S-phase duration in plants. Journal of experimental botany. 2016 11; 67(21):6077-6087. doi: 10.1093/jxb/erw367. [PMID: 27697785]
  • Julianne L Holleran, Julie L Eiseman, Robert A Parise, Shivaani Kummar, Jan H Beumer. LC-MS/MS assay for the quantitation of FdCyd and its metabolites FdUrd and FU in human plasma. Journal of pharmaceutical and biomedical analysis. 2016 Sep; 129(?):359-366. doi: 10.1016/j.jpba.2016.07.027. [PMID: 27454087]
  • Xiaofeng Yin, Hirokazu Tsukaya. A pulse-chase strategy for EdU labelling assay is able to rapidly quantify cell division orientation. The New phytologist. 2016 09; 211(4):1462-9. doi: 10.1111/nph.13980. [PMID: 27121010]
  • Jienny Lee, Moon Sam Shin, Mi Ok Kim, Sunghee Jang, Sae Woong Oh, Mingyeong Kang, Kwangseon Jung, Yong Seek Park, Jongsung Lee. Apple ethanol extract promotes proliferation of human adult stem cells, which involves the regenerative potential of stem cells. Nutrition research (New York, N.Y.). 2016 09; 36(9):925-936. doi: 10.1016/j.nutres.2016.06.010. [PMID: 27632912]
  • Debanti Sengupta, Guillem Pratx. Single-Cell Characterization of 18F-FLT Uptake with Radioluminescence Microscopy. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2016 07; 57(7):1136-40. doi: 10.2967/jnumed.115.167734. [PMID: 27081170]
  • Ellen J B Derissen, Bart A W Jacobs, Alwin D R Huitema, Hilde Rosing, Jan H M Schellens, Jos H Beijnen. Exploring the intracellular pharmacokinetics of the 5-fluorouracil nucleotides during capecitabine treatment. British journal of clinical pharmacology. 2016 May; 81(5):949-57. doi: 10.1111/bcp.12877. [PMID: 26718616]
  • Anita Kazda, Svetlana Akimcheva, J Matthew Watson, Karel Riha. Cell Proliferation Analysis Using EdU Labeling in Whole Plant and Histological Samples of Arabidopsis. Methods in molecular biology (Clifton, N.J.). 2016; 1370(?):169-82. doi: 10.1007/978-1-4939-3142-2_13. [PMID: 26659962]
  • Emily E Wear, Lorenzo Concia, Ashley M Brooks, Emily A Markham, Tae-Jin Lee, George C Allen, William F Thompson, Linda Hanley-Bowdoin. Isolation of Plant Nuclei at Defined Cell Cycle Stages Using EdU Labeling and Flow Cytometry. Methods in molecular biology (Clifton, N.J.). 2016; 1370(?):69-86. doi: 10.1007/978-1-4939-3142-2_6. [PMID: 26659955]
  • Haiyang Jiang, Lei Zhao, Xiaoshen Dong, Anning He, Caiwei Zheng, Magnus Johansson, Anna Karlsson, Xinyu Zheng. Tanshinone IIA enhances bystander cell killing of cancer cells expressing Drosophila melanogaster deoxyribonucleoside kinase in nuclei and mitochondria. Oncology reports. 2015 Sep; 34(3):1487-93. doi: 10.3892/or.2015.4102. [PMID: 26134602]
  • Siyoong Seo, Kazumitsu Onizuka, Chieko Nishioka, Eiki Takahashi, Satoshi Tsuneda, Hiroshi Abe, Yoshihiro Ito. Phosphorylated 5-ethynyl-2'-deoxyuridine for advanced DNA labeling. Organic & biomolecular chemistry. 2015 Apr; 13(15):4589-95. doi: 10.1039/c5ob00199d. [PMID: 25777799]
  • Lucia Martiniova, Martha S Field, Julia L Finkelstein, Cheryll A Perry, Patrick J Stover. Maternal dietary uridine causes, and deoxyuridine prevents, neural tube closure defects in a mouse model of folate-responsive neural tube defects. The American journal of clinical nutrition. 2015 Apr; 101(4):860-9. doi: 10.3945/ajcn.114.097279. [PMID: 25833982]
  • Mickaël Bourge, Cécile Fort, Marie-Noëlle Soler, Béatrice Satiat-Jeunemaître, Spencer C Brown. A pulse-chase strategy combining click-EdU and photoconvertible fluorescent reporter: tracking Golgi protein dynamics during the cell cycle. The New phytologist. 2015 Jan; 205(2):938-50. doi: 10.1111/nph.13069. [PMID: 25266734]
  • Jianwen Wang, Guiting Lin, Amjad Alwaal, Xiaoyu Zhang, Guifang Wang, Xingyuan Jia, Lia Banie, Jacqueline Villalta, Ching-Shwun Lin, Tom F Lue. Kinetics of Label Retaining Cells in the Developing Rat Kidneys. PloS one. 2015; 10(12):e0144734. doi: 10.1371/journal.pone.0144734. [PMID: 26650841]
  • Sunil Rangarajan, Bhuvana Sunil, Chunlan Fan, Pei-Xuan Wang, Gary Cutter, Paul W Sanders, Lisa M Curtis. Distinct populations of label-retaining cells in the adult kidney are defined temporally and exhibit divergent regional distributions. American journal of physiology. Renal physiology. 2014 Dec; 307(11):F1274-82. doi: 10.1152/ajprenal.00213.2014. [PMID: 25234315]
  • Alexander N Combes, Kieran M Short, James Lefevre, Nicholas A Hamilton, Melissa H Little, Ian M Smyth. An integrated pipeline for the multidimensional analysis of branching morphogenesis. Nature protocols. 2014 Dec; 9(12):2859-79. doi: 10.1038/nprot.2014.193. [PMID: 25411953]
  • Mohd Ishtikhar, Shawez Khan, Gamal Badr, Amany Osama Mohamed, Rizwan Hasan Khan. Interaction of the 5-fluorouracil analog 5-fluoro-2'-deoxyuridine with 'N' and 'B' isoforms of human serum albumin: a spectroscopic and calorimetric study. Molecular bioSystems. 2014 Nov; 10(11):2954-64. doi: 10.1039/c4mb00306c. [PMID: 25141914]
  • Weilun Sun, Tilly Wilhelmina Aalders, Egbert Oosterwijk. Identification of potential bladder progenitor cells in the trigone. Developmental biology. 2014 Sep; 393(1):84-92. doi: 10.1016/j.ydbio.2014.06.018. [PMID: 24992712]
  • Christoph Spahn, Ulrike Endesfelder, Mike Heilemann. Super-resolution imaging of Escherichia coli nucleoids reveals highly structured and asymmetric segregation during fast growth. Journal of structural biology. 2014 Mar; 185(3):243-9. doi: 10.1016/j.jsb.2014.01.007. [PMID: 24473063]
  • Susan Mohamed, Leonardo Caporali, Roberto De Giorgio, Valerio Carelli, Manuela Contin. HPLC-UV analysis of thymidine and deoxyuridine in plasma of patients with thymidine phosphorylase deficiency. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Feb; 949-950(?):58-62. doi: 10.1016/j.jchromb.2014.01.003. [PMID: 24463401]
  • Jian-hua Huang, Wai-jiao Cai, Xin-min Zhang, Zi-yin Shen. Icariin promotes self-renewal of neural stem cells: an involvement of extracellular regulated kinase signaling pathway. Chinese journal of integrative medicine. 2014 Feb; 20(2):107-15. doi: 10.1007/s11655-013-1583-7. [PMID: 24619236]
  • Yuan Yuan, Jun-Mian Tian, Jian Xiao, Qi Shao, Jin-Ming Gao. Bioactive metabolites isolated from Penicillium sp. YY-20, the endophytic fungus from Ginkgo biloba. Natural product research. 2014; 28(4):278-81. doi: 10.1080/14786419.2013.850686. [PMID: 24144081]
  • Enaksha R Wickremsinhe, Lisa B Lee, Chris A Schmalz, John Torchia, Kenneth J Ruterbories. High sensitive assay employing column switching chromatography to enable simultaneous quantification of an amide prodrug of gemcitabine (LY2334737), gemcitabine, and its metabolite dFdU in human plasma by LC-MS/MS. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2013 Aug; 932(?):117-22. doi: 10.1016/j.jchromb.2013.06.008. [PMID: 23831704]
  • Susan E Pratt, Sara Durland-Busbice, Robert L Shepard, Gregory P Donoho, James J Starling, Enaksha R Wickremsinhe, Everett J Perkins, Anne H Dantzig. Efficacy of low-dose oral metronomic dosing of the prodrug of gemcitabine, LY2334737, in human tumor xenografts. Molecular cancer therapeutics. 2013 Apr; 12(4):481-90. doi: 10.1158/1535-7163.mct-12-0654. [PMID: 23371859]
  • Susan E Pratt, Sara Durland-Busbice, Robert L Shepard, Kathleen Heinz-Taheny, Philip W Iversen, Anne H Dantzig. Human carboxylesterase-2 hydrolyzes the prodrug of gemcitabine (LY2334737) and confers prodrug sensitivity to cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research. 2013 Mar; 19(5):1159-68. doi: 10.1158/1078-0432.ccr-12-1184. [PMID: 23325581]
  • Virginie Frings, Astrid A M van der Veldt, Ronald Boellaard, Gerarda J M Herder, Elisa Giovannetti, Richard Honeywell, Godefridus J Peters, Erik Thunnissen, Otto S Hoekstra, Egbert F Smit. Pemetrexed induced thymidylate synthase inhibition in non-small cell lung cancer patients: a pilot study with 3'-deoxy-3'-[¹⁸F]fluorothymidine positron emission tomography. PloS one. 2013; 8(5):e63705. doi: 10.1371/journal.pone.0063705. [PMID: 23717468]
  • Jienny Lee, Kyung-Baeg Roh, Sang-Cheol Kim, Jongsung Lee, Deokhoon Park. Soy peptide-induced stem cell proliferation: involvement of ERK and TGF-β1. The Journal of nutritional biochemistry. 2012 Oct; 23(10):1341-51. doi: 10.1016/j.jnutbio.2011.08.003. [PMID: 22217516]
  • Minoru Tomizawa, Fuminobu Shinozaki, Takao Sugiyama, Shigenori Yamamoto, Makoto Sueishi, Takanobu Yoshida. Insulin-like growth factor I receptor involvement in proliferation of NOR-P1 cells in serum-free media. Journal of cellular biochemistry. 2012 Aug; 113(8):2714-20. doi: 10.1002/jcb.24149. [PMID: 22441995]
  • Elisa Zavattaro, Francesca Boccafoschi, Cinzia Borgogna, Alessandro Conca, Roch Christian Johnson, Ghislain Emmanuel Sopoh, Ange Dodji Dossou, Enrico Colombo, Claudio Clemente, Giorgio Leigheb, Guido Valente. Apoptosis in Buruli ulcer: a clinicopathological study of 45 cases. Histopathology. 2012 Aug; 61(2):224-36. doi: 10.1111/j.1365-2559.2012.04206.x. [PMID: 22439755]
  • M E Ilatovskaia, V F Pozdnev, A A Andreev-Andrievskiĭ, N A Medvedeva. [Protective effect of endothelin-1 in goldblatt 'one-kidney, one-clip' hypertension]. Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova. 2012 Jul; 98(7):836-44. doi: NULL. [PMID: 23074831]
  • Hiromitsu Hayashi, Keiko Sakai, Hideo Baba, Takao Sakai. Thrombospondin-1 is a novel negative regulator of liver regeneration after partial hepatectomy through transforming growth factor-beta1 activation in mice. Hepatology (Baltimore, Md.). 2012 May; 55(5):1562-73. doi: 10.1002/hep.24800. [PMID: 22105716]
  • Robert C Jackson. Pharmacodynamic modelling of biomarker data in oncology. ISRN pharmacology. 2012; 2012(?):590626. doi: 10.5402/2012/590626. [PMID: 22523699]
  • Ramon Martí, Luis C López, Michio Hirano. Assessment of thymidine phosphorylase function: measurement of plasma thymidine (and deoxyuridine) and thymidine phosphorylase activity. Methods in molecular biology (Clifton, N.J.). 2012; 837(?):121-33. doi: 10.1007/978-1-61779-504-6_8. [PMID: 22215544]
  • Atchayaram Nalini, Narayanappa Gayathri. Mitochondrial neurogastrointestinal encephalopathy in an Indian family with possible manifesting carriers of heterozygous TYMP mutation. Journal of the neurological sciences. 2011 Oct; 309(1-2):131-5. doi: 10.1016/j.jns.2011.06.052. [PMID: 21794876]
  • Agnieszka Morgenroth, Cornelia Dinger, Boris D Zlatopolskiy, Ehab Al-Momani, Gerhard Glatting, Felix M Mottaghy, Sven N Reske. Auger electron emitter against multiple myeloma--targeted endo-radio-therapy with 125I-labeled thymidine analogue 5-iodo-4'-thio-2'-deoxyuridine. Nuclear medicine and biology. 2011 Oct; 38(7):1067-77. doi: 10.1016/j.nucmedbio.2011.02.018. [PMID: 21982576]
  • C E de Bock, M B Garg, N Scott, J A Sakoff, F E Scorgie, S P Ackland, L F Lincz. Association of thymidylate synthase enhancer region polymorphisms with thymidylate synthase activity in vivo. The pharmacogenomics journal. 2011 Aug; 11(4):307-14. doi: 10.1038/tpj.2010.43. [PMID: 20531375]
  • Sarah Schott, Markus Wallwiener, Beate Kootz, Harald Seeger, Tanja Fehm, Hans Neubauer. ATP chemosensitivity testing of new antitumor duplex drugs linking 3`-C-ethynylycytidine (ECyd) and 2´-deoxy-5-fluorouridine (5-FdU) in comparison to standard cytostatica and combinations thereof. Investigational new drugs. 2011 Jun; 29(3):506-13. doi: 10.1007/s10637-009-9355-0. [PMID: 19997962]
  • Sugihiro Ando, Yuko Sato, Hideyuki Shigemori, Takafumi Shimizu, Kazunori Okada, Hisakazu Yamane, Yusuke Jikumaru, Yuji Kamiya, Kosumi Yamada, Chiharu Akimoto-Tomiyama, Shigeru Tanabe, Yoko Nishizawa, Eiichi Minami. Identification and characterization of 2'-deoxyuridine from the supernatant of conidial suspensions of rice blast fungus as an infection-promoting factor in rice plants. Molecular plant-microbe interactions : MPMI. 2011 May; 24(5):519-32. doi: 10.1094/mpmi-07-10-0172. [PMID: 21171893]
  • Emeline Dubois, Dolores Córdoba-Cañero, Sophie Massot, Nicolas Siaud, Bertrand Gakière, Séverine Domenichini, Florence Guérard, Teresa Roldan-Arjona, Marie-Pascale Doutriaux. Homologous recombination is stimulated by a decrease in dUTPase in Arabidopsis. PloS one. 2011 Apr; 6(4):e18658. doi: 10.1371/journal.pone.0018658. [PMID: 21541310]
  • Isam Abdel-Karim, William K Plunkett, Susan O'Brien, Francis Giles, Deborah Thomas, Stefan Faderl, Farhad Ravandi, Mary Beth Rios, Min Du, Karen B Schneck, Victor J Chen, Boris K Lin, Steven J Nicol, Hagop M Kantarjian. A phase I study of pemetrexed in patients with relapsed or refractory acute leukemia. Investigational new drugs. 2011 Apr; 29(2):323-31. doi: 10.1007/s10637-009-9369-7. [PMID: 20091088]
  • Eileen M McGowan, Nikki Alling, Elise A Jackson, Daniel Yagoub, Nikolas K Haass, John D Allen, Rosetta Martinello-Wilks. Evaluation of cell cycle arrest in estrogen responsive MCF-7 breast cancer cells: pitfalls of the MTS assay. PloS one. 2011; 6(6):e20623. doi: 10.1371/journal.pone.0020623. [PMID: 21673993]
  • Kitty Chui, Alpa Trivedi, C Yan Cheng, Diana B Cherbavaz, Paul F Dazin, Ai Lam Thu Huynh, James B Mitchell, Gabriel A Rabinovich, Linda J Noble-Haeusslein, Constance M John. Characterization and functionality of proliferative human Sertoli cells. Cell transplantation. 2011; 20(5):619-35. doi: 10.3727/096368910x536563. [PMID: 21054948]
  • Stephen O Opiyo, Rosevelt L Pardy, Hideaki Moriyama, Etsuko N Moriyama. Evolution of the Kdo2-lipid A biosynthesis in bacteria. BMC evolutionary biology. 2010 Nov; 10(?):362. doi: 10.1186/1471-2148-10-362. [PMID: 21106097]
  • Leena Maddukuri, Robert L Eoff, Jeong-Yun Choi, Carmelo J Rizzo, F Peter Guengerich, Lawrence J Marnett. In vitro bypass of the major malondialdehyde- and base propenal-derived DNA adduct by human Y-family DNA polymerases κ, ι, and Rev1. Biochemistry. 2010 Sep; 49(38):8415-24. doi: 10.1021/bi1009024. [PMID: 20726503]
  • Jian-Fei Xia, Ping Hu, Qiong-Lin Liang, Ting-Ting Zou, Yi-Ming Wang, Guo-An Luo. Correlations of creatine and six related pyrimidine metabolites and diabetic nephropathy in Chinese type 2 diabetic patients. Clinical biochemistry. 2010 Aug; 43(12):957-62. doi: 10.1016/j.clinbiochem.2010.05.013. [PMID: 20510896]
  • Kim H Hebelstrup, Michael W Christiansen, Massimiliano Carciofi, Birgitte Tauris, Henrik Brinch-Pedersen, Preben B Holm. UCE: A uracil excision (USER)-based toolbox for transformation of cereals. Plant methods. 2010 Jun; 6(?):15. doi: 10.1186/1746-4811-6-15. [PMID: 20537147]
  • Jan Gerard Maring, Floris M Wachters, Monique Slijfer, J Marina Maurer, H Marike Boezen, Donald R A Uges, Elisabeth G E de Vries, Harry J M Groen. Pharmacokinetics of gemcitabine in non-small-cell lung cancer patients: impact of the 79A>C cytidine deaminase polymorphism. European journal of clinical pharmacology. 2010 Jun; 66(6):611-7. doi: 10.1007/s00228-010-0799-0. [PMID: 20213492]
  • Steven F Werder. Cobalamin deficiency, hyperhomocysteinemia, and dementia. Neuropsychiatric disease and treatment. 2010 May; 6(?):159-95. doi: 10.2147/ndt.s6564. [PMID: 20505848]
  • Sven Kroening, Emily Neubauer, Bernd Wullich, Jan Aten, Margarete Goppelt-Struebe. Characterization of connective tissue growth factor expression in primary cultures of human tubular epithelial cells: modulation by hypoxia. American journal of physiology. Renal physiology. 2010 Mar; 298(3):F796-806. doi: 10.1152/ajprenal.00528.2009. [PMID: 20032117]
  • Lei O Li, Yun-Fu Hu, Lily Wang, Matthew Mitchell, Alvin Berger, Rosalind A Coleman. Early hepatic insulin resistance in mice: a metabolomics analysis. Molecular endocrinology (Baltimore, Md.). 2010 Mar; 24(3):657-66. doi: 10.1210/me.2009-0152. [PMID: 20150186]
  • Juan Kang, Xiaoling Wu, Zhigang Wang, Haitao Ran, Chuanshan Xu, Jinfeng Wu, Zhaoxia Wang, Yong Zhang. Antitumor effect of docetaxel-loaded lipid microbubbles combined with ultrasound-targeted microbubble activation on VX2 rabbit liver tumors. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine. 2010 Jan; 29(1):61-70. doi: 10.7863/jum.2010.29.1.61. [PMID: 20040776]
  • Abigail A Lamikanra, Michel Theron, Taco W A Kooij, David J Roberts. Hemozoin (malarial pigment) directly promotes apoptosis of erythroid precursors. PloS one. 2009 Dec; 4(12):e8446. doi: 10.1371/journal.pone.0008446. [PMID: 20041181]
  • Zbigniew P Kortylewicz, Jessica Nearman, Janina Baranowska-Kortylewicz. Radiolabeled 5-iodo-3'-O-(17beta-succinyl-5alpha-androstan-3-one)-2'-deoxyuridine and its 5'-monophosphate for imaging and therapy of androgen receptor-positive cancers: synthesis and biological evaluation. Journal of medicinal chemistry. 2009 Aug; 52(16):5124-43. doi: 10.1021/jm9005803. [PMID: 19653647]
  • Mary R Sweeney, Anthony Staines, Leslie Daly, Aisling Traynor, Sean Daly, Steven W Bailey, Patricia B Alverson, June E Ayling, John M Scott. Persistent circulating unmetabolised folic acid in a setting of liberal voluntary folic acid fortification. Implications for further mandatory fortification?. BMC public health. 2009 Aug; 9(?):295. doi: 10.1186/1471-2458-9-295. [PMID: 19689788]
  • John B Tyburski, Andrew D Patterson, Kristopher W Krausz, Josef Slavík, Albert J Fornace, Frank J Gonzalez, Jeffrey R Idle. Radiation metabolomics. 2. Dose- and time-dependent urinary excretion of deaminated purines and pyrimidines after sublethal gamma-radiation exposure in mice. Radiation research. 2009 Jul; 172(1):42-57. doi: 10.1667/rr1703.1. [PMID: 19580506]
  • Fengling Cui, Yinghua Yan, Qiangzhai Zhang, Juan Du, Xiaojun Yao, Guirong Qu, Yan Lu. Characterization of the interaction between 2'-deoxyuridine and human serum albumin. Carbohydrate research. 2009 Mar; 344(5):642-7. doi: 10.1016/j.carres.2009.01.009. [PMID: 19215910]
  • Yi-Heng Li, Hsing-Chun Chung, Shu-Lin Liu, Ting-Hsing Chao, Jian-Chyi Chen. A novel inhibitory effect of Antrodia camphorata extract on vascular smooth muscle cell migration and neointima formation in mice. International heart journal. 2009 Mar; 50(2):207-20. doi: 10.1536/ihj.50.207. [PMID: 19367031]
  • Kenneth A Jacobson, Andrei A Ivanov, Sonia de Castro, T Kendall Harden, Hyojin Ko. Development of selective agonists and antagonists of P2Y receptors. Purinergic signalling. 2009 Mar; 5(1):75-89. doi: 10.1007/s11302-008-9106-2. [PMID: 18600475]
  • Yoshinaga Yoshimura, Hajime Okada, Tomoko Ohtake, Tadashi Tsukaguchi, Kenzo Fujimoto. A selective and sensitive detection of SNP between rice cultivars by using DNA photoligation. Nucleic acids symposium series (2004). 2009; ?(53):199-200. doi: 10.1093/nass/nrp100. [PMID: 19749329]
  • N F Moran, M D Bain, M M K Muqit, B E Bax. Carrier erythrocyte entrapped thymidine phosphorylase therapy for MNGIE. Neurology. 2008 Aug; 71(9):686-8. doi: 10.1212/01.wnl.0000324602.97205.ab. [PMID: 18725595]
  • Leonard I Wiebe, Xiao-Hong Yang, Shradha Singh, Jim Diakur. Preparation and preliminary evaluation of novel beta-cyclodextrin/IUDR prodrug formulations. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques. 2008 Jun; 11(2):32s-43s. doi: 10.18433/j3w88t. [PMID: 19203469]
  • Radhakrishna G Pillai, Martin Forster, Meg Perumal, Fraser Mitchell, Julius Leyton, Franklin I Aibgirhio, Oksana Golovko, Ann L Jackman, Eric O Aboagye. Imaging pharmacodynamics of the alpha-folate receptor-targeted thymidylate synthase inhibitor BGC 945. Cancer research. 2008 May; 68(10):3827-34. doi: 10.1158/0008-5472.can-08-0135. [PMID: 18483267]
  • Annette Adler, Nicole Forster, Matthias Homann, H Ulrich Göringer. Post-SELEX chemical optimization of a trypanosome-specific RNA aptamer. Combinatorial chemistry & high throughput screening. 2008 Jan; 11(1):16-23. doi: 10.2174/138620708783398331. [PMID: 18220540]
  • K M Li, L P Rivory, S J Clarke. Pemetrexed pharmacokinetics and pharmacodynamics in a phase I/II study of doublet chemotherapy with vinorelbine: implications for further optimisation of pemetrexed schedules. British journal of cancer. 2007 Oct; 97(8):1071-6. doi: 10.1038/sj.bjc.6603995. [PMID: 17912246]
  • Jutatip Kintarak, Teerin Liewluck, Tumtip Sangruchi, Michio Hirano, Kongkiat Kulkantrakorn, Sombat Muengtaweepongsa. A novel ECGF1 mutation in a Thai patient with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). Clinical neurology and neurosurgery. 2007 Sep; 109(7):613-6. doi: 10.1016/j.clineuro.2007.04.008. [PMID: 17544574]
  • Maria Lucia Valentino, Ramon Martí, Saba Tadesse, Luis Carlos López, Jose L Manes, Judy Lyzak, Angelika Hahn, Valerio Carelli, Michio Hirano. Thymidine and deoxyuridine accumulate in tissues of patients with mitochondrial neurogastrointestinal encephalomyopathy (MNGIE). FEBS letters. 2007 Jul; 581(18):3410-4. doi: 10.1016/j.febslet.2007.06.042. [PMID: 17612528]
  • Andreas T J Vogg, Andreas K Buck, Michaela Schmid, Bernd Neumaier, Katrin Wczasek, Boris D Zlatopolskiy, Sven N Reske. Synthesis and biodistribution of 3'-fluoro-5-[(131)I]iodo-2'-deoxyuridine: a comparative study of [(131)I]FLIdU and [(18)F]FLT. Nuclear medicine and biology. 2007 Apr; 34(3):273-81. doi: 10.1016/j.nucmedbio.2006.12.010. [PMID: 17383577]
  • Mary Rose Sweeney, Joseph McPartlin, John Scott. Folic acid fortification and public health: report on threshold doses above which unmetabolised folic acid appear in serum. BMC public health. 2007 Mar; 7(?):41. doi: 10.1186/1471-2458-7-41. [PMID: 17378936]
  • Halûk Yavuz, Ahmet Ozel, Mette Christensen, Ernst Christensen, Marianne Schwartz, Mithat Elmaci, John Vissing. Treatment of mitochondrial neurogastrointestinal encephalomyopathy with dialysis. Archives of neurology. 2007 Mar; 64(3):435-8. doi: 10.1001/archneur.64.3.435. [PMID: 17353390]
  • Alexander Vogetseder, Thomas Palan, Desa Bacic, Brigitte Kaissling, Michel Le Hir. Proximal tubular epithelial cells are generated by division of differentiated cells in the healthy kidney. American journal of physiology. Cell physiology. 2007 Feb; 292(2):C807-13. doi: 10.1152/ajpcell.00301.2006. [PMID: 16987990]
  • Kong M Li, Laurent P Rivory, Janelle Hoskins, Rohini Sharma, Stephen J Clarke. Altered deoxyuridine and thymidine in plasma following capecitabine treatment in colorectal cancer patients. British journal of clinical pharmacology. 2007 Jan; 63(1):67-74. doi: 10.1111/j.1365-2125.2006.02710.x. [PMID: 16827816]
  • Katsuya Kobayashi, Toshio Suda, Haruhiko Manabe, Ichiro Miki. Administration of PDE4 inhibitors suppressed the pannus-like inflammation by inhibition of cytokine production by macrophages and synovial fibroblast proliferation. Mediators of inflammation. 2007; 2007(?):58901. doi: 10.1155/2007/58901. [PMID: 18274640]
  • M C Lara, B Weiss, I Illa, P Madoz, L Massuet, A L Andreu, M L Valentino, Y Anikster, M Hirano, R Martí. Infusion of platelets transiently reduces nucleoside overload in MNGIE. Neurology. 2006 Oct; 67(8):1461-3. doi: 10.1212/01.wnl.0000239824.95411.52. [PMID: 16971699]
  • Meg Perumal, Radhakrishna G Pillai, Henryk Barthel, Julius Leyton, John R Latigo, Martin Forster, Fraser Mitchell, Ann L Jackman, Eric O Aboagye. Redistribution of nucleoside transporters to the cell membrane provides a novel approach for imaging thymidylate synthase inhibition by positron emission tomography. Cancer research. 2006 Sep; 66(17):8558-64. doi: 10.1158/0008-5472.can-06-0898. [PMID: 16951168]
  • Giovanna Pontarin, Paola Ferraro, Maria L Valentino, Michio Hirano, Peter Reichard, Vera Bianchi. Mitochondrial DNA depletion and thymidine phosphate pool dynamics in a cellular model of mitochondrial neurogastrointestinal encephalomyopathy. The Journal of biological chemistry. 2006 Aug; 281(32):22720-8. doi: 10.1074/jbc.m604498200. [PMID: 16774911]