AIDS-113822 (BioDeep_00000865344)

Main id: BioDeep_00000001208

 

PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1-H-pyrimidine-2,4-dione

化学式: C9H12N2O5 (228.07461819999997)
中文名称: 2’-脱氧尿苷, 脱氧尿苷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1C(C(OC1N2C=CC(=O)NC2=O)CO)O
InChI: InChI=1S/C9H12N2O5/c12-4-6-5(13)3-8(16-6)11-2-1-7(14)10-9(11)15/h1-2,5-6,8,12-13H,3-4H2,(H,10,14,15)/t5-,6+,8+/m0/s1

描述信息

D009676 - Noxae > D000963 - Antimetabolites
COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine.
2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine.
2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine.

同义名列表

28 个代谢物同义名

1-((2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1-H-pyrimidine-2,4-dione; 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidine-2,4-dione; 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)-2-tetrahydrofuranyl]pyrimidine-2,4-dione; 1-[(2R,4S,5R)-4-hydroxy-5-methylol-tetrahydrofuran-2-yl]pyrimidine-2,4-quinone; 1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione; 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-beta-D-erythro-ribofuranosyl)-; 2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-beta-D-ribofuranosyl)-; 1-(2-Deoxy-beta-D-erythro-pentofuranoxyl)uracil; 4-24-00-01200 (Beilstein Handbook Reference); EINECS 213-455-7; 2′-Deoxyuridine; NCGC00142492-01; 2-deoxyuridine; ZINC00155696; SMR000112296; MLS001066344; AIDS-113822; D5412_SIGMA; BRN 0024433; CCRIS 2832; AIDS113822; 20649-53-0; NSC 23615; ST057093; C00526; dURD; DUR; 2'-Deoxyuridine



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(5)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

11 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Peihua Gan, Peiling Li, Xiaolin Zhang, Hailin Li, Shaojie Ma, Dan Zong, Chengzhong He. Comparative Transcriptomic and Metabolomic Analyses of Differences in Trunk Spiral Grain in Pinus yunnanensis. International journal of molecular sciences. 2023 Sep; 24(19):. doi: 10.3390/ijms241914658. [PMID: 37834105]
  • Junjie Yang, Jiayu Liu, Jing Li, Ming Jing, Leiming Zhang, Mengmeng Sun, Qiaoyun Wang, Hongliu Sun, Guige Hou, Chunhua Wang, Wenyu Xin. Celastrol inhibits rheumatoid arthritis by inducing autophagy via inhibition of the PI3K/AKT/mTOR signaling pathway. International immunopharmacology. 2022 Nov; 112(?):109241. doi: 10.1016/j.intimp.2022.109241. [PMID: 36116150]
  • Yang Jiang, Junshuang Zhao, Rongqing Li, Yingliang Liu, Lin Zhou, Chengbin Wang, Caihong Lv, Liang Gao, Daming Cui. CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis. Journal of experimental & clinical cancer research : CR. 2022 Oct; 41(1):307. doi: 10.1186/s13046-022-02518-8. [PMID: 36266731]
  • Markus Niehaus, Henryk Straube, André Specht, Chiara Baccolini, Claus-Peter Witte, Marco Herde. The nucleotide metabolome of germinating Arabidopsis thaliana seeds reveals a central role for thymidine phosphorylation in chloroplast development. The Plant cell. 2022 09; 34(10):3790-3813. doi: 10.1093/plcell/koac207. [PMID: 35861422]
  • Aleksandra Skalska-Bugala, Marta Starczak, Łukasz Szukalski, Maciej Gawronski, Agnieszka Siomek-Gorecka, Justyna Szpotan, Anna Labejszo, Ewelina Zarakowska, Anna Szpila, Anna Jachalska, Adriana Szukalska, Marcin Kruszewski, Anna Sadowska, Aleksandra Wasilow, Patrycja Baginska, Jaroslaw Czyz, Ryszard Olinski, Rafal Rozalski, Daniel Gackowski. Diagnostic and Prognostic Power of Active DNA Demethylation Pathway Intermediates in Acute Myelogenous Leukemia and Myelodysplastic Syndromes. Cells. 2022 03; 11(5):. doi: 10.3390/cells11050888. [PMID: 35269510]
  • Dmitry I Maltsev, Kennelia A Mellanson, Vsevolod V Belousov, Grigori N Enikolopov, Oleg V Podgorny. The bioavailability time of commonly used thymidine analogues after intraperitoneal delivery in mice: labeling kinetics in vivo and clearance from blood serum. Histochemistry and cell biology. 2022 Feb; 157(2):239-250. doi: 10.1007/s00418-021-02048-y. [PMID: 34757474]
  • Michael D Waters, Stafford Warren, Claude Hughes, Philip Lewis, Fengyu Zhang. Human genetic risk of treatment with antiviral nucleoside analog drugs that induce lethal mutagenesis: The special case of molnupiravir. Environmental and molecular mutagenesis. 2022 01; 63(1):37-63. doi: 10.1002/em.22471. [PMID: 35023215]
  • Prateek Srivastava, Ankush Paladhi, Ranjeet Singh, Divesh Narayan Srivastava, Ram Adhar Singh, Sumit Kumar Hira, Partha Pratim Manna. Targeting PD-1 in CD8+ T Cells with a Biomimetic Bilirubin-5-fluoro-2-deoxyuridine-Bovine Serum Albumin Nanoconstruct for Effective Chemotherapy against Experimental Lymphoma. Molecular pharmaceutics. 2021 05; 18(5):2053-2065. doi: 10.1021/acs.molpharmaceut.1c00050. [PMID: 33886324]
  • Nadhiratul-Farihin Semail, Siti Salmah Noordin, Aemi Syazwani Abdul Keyon, Maisarah Nasution Waras, Bahruddin Saad, Sazlinda Kamaruzaman, Nur Nadhirah Mohamad Zain, Juzaili Azizi, Mohd Yusmaidie Aziz, Noorfatimah Yahaya. A simple and efficient sequential electrokinetic and hydrodynamic injections in micellar electrokinetic chromatography method for quantification of anticancer drug 5-fluorouracil and its metabolite in human plasma. Biomedical chromatography : BMC. 2021 May; 35(5):e5050. doi: 10.1002/bmc.5050. [PMID: 33314228]
  • Hirotomo Takatsuka, Masaaki Umeda. Whole-Mount Immunostaining for the Identification of Histone Modifications in the S-Phase Nuclei of Arabidopsis Roots. Methods in molecular biology (Clifton, N.J.). 2021; 2329(?):71-80. doi: 10.1007/978-1-0716-1538-6_6. [PMID: 34085216]
  • Helena Taflin, Elisabeth Odin, Göran Carlsson, Roger Tell, Bengt Gustavsson, Yvonne Wettergren. Plasma deoxyuridine as a surrogate marker for toxicity and early clinical response in patients with metastatic colorectal cancer after 5-FU-based therapy in combination with arfolitixorin. Cancer chemotherapy and pharmacology. 2021 01; 87(1):31-41. doi: 10.1007/s00280-020-04173-2. [PMID: 33099678]
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  • Cancan Yang, Jing Li, Zhenling Huang, Xuefa Zhang, Xiaolei Gao, Chunyuang Zhu, Paul F Morris, XiuGuo Zhang. Structural and catalytic analysis of two diverse uridine phosphorylases in Phytophthora capsici. Scientific reports. 2020 06; 10(1):9051. doi: 10.1038/s41598-020-65935-9. [PMID: 32493959]
  • Jonatan Darr, Archana Tomar, Maximilian Lassi, Raffaele Gerlini, Lucia Berti, Annette Hering, Fabienne Scheid, Martin Hrabě de Angelis, Michael Witting, Raffaele Teperino. iTAG-RNA Isolates Cell-Specific Transcriptional Responses to Environmental Stimuli and Identifies an RNA-Based Endocrine Axis. Cell reports. 2020 03; 30(9):3183-3194.e4. doi: 10.1016/j.celrep.2020.02.020. [PMID: 32130917]
  • Rieko Fujinami. Analysis of Cell Division Frequency in the Root Apical Meristem of Lycophytes, Non-seed Vascular Plants, Using EdU Labeling. Methods in molecular biology (Clifton, N.J.). 2020; 2094(?):91-99. doi: 10.1007/978-1-0716-0183-9_10. [PMID: 31797294]
  • Ravi Patel, Lucia Lee Coulter, Joanna Rimmer, Miles Parkes, Patrick Francis Chinnery, Oscar Swift. Mitochondrial neurogastrointestinal encephalopathy: a clinicopathological mimic of Crohn's disease. BMC gastroenterology. 2019 Jan; 19(1):11. doi: 10.1186/s12876-018-0925-5. [PMID: 30646848]
  • Xiaoting Shu, Menghao Liu, Zhike Lu, Chenxu Zhu, Haowei Meng, Sihao Huang, Xiaoxue Zhang, Chengqi Yi. Genome-wide mapping reveals that deoxyuridine is enriched in the human centromeric DNA. Nature chemical biology. 2018 07; 14(7):680-687. doi: 10.1038/s41589-018-0065-9. [PMID: 29785056]
  • Chloé Michel, Rita Küchler, Iris Martin, Bruno Kyewski, Sheena Pinto. An efficient protocol for in vivo labeling of proliferating epithelial cells. Journal of immunological methods. 2018 06; 457(?):82-86. doi: 10.1016/j.jim.2018.03.015. [PMID: 29605230]
  • Jolanta Kwasniewska, Karolina Zubrzycka, Arita Kus. Impact of Mutagens on DNA Replication in Barley Chromosomes. International journal of molecular sciences. 2018 Apr; 19(4):. doi: 10.3390/ijms19041070. [PMID: 29614057]
  • Martina Dvořáčková, Berta Raposo, Petr Matula, Joerg Fuchs, Veit Schubert, Vratislav Peška, Bénédicte Desvoyes, Crisanto Gutierrez, Jiří Fajkus. Replication of ribosomal DNA in Arabidopsis occurs both inside and outside the nucleolus during S phase progression. Journal of cell science. 2018 01; 131(2):. doi: 10.1242/jcs.202416. [PMID: 28483825]
  • I F Usynin, A N Dudarev, A Yu Gorodetskaya, S M Miroshnichenko, T A Tkachenko, V I Tkachenko. Apolipoprotein A-I Stimulates Cell Proliferation in Bone Marrow Cell Culture. Bulletin of experimental biology and medicine. 2018 Jan; 164(3):308-311. doi: 10.1007/s10517-018-3978-0. [PMID: 29313227]
  • Michelle Levene, Francisco J Enguita, Bridget E Bax. Discovery profiling and bioinformatics analysis of serum microRNA in Mitochondrial NeuroGastroIntestinal Encephalomyopathy (MNGIE). Nucleosides, nucleotides & nucleic acids. 2018; 37(11):618-629. doi: 10.1080/15257770.2018.1492138. [PMID: 30587073]
  • Benjamin Röeben, Justus Marquetand, Benjamin Bender, Heiko Billing, Tobias B Haack, Iciar Sanchez-Albisua, Ludger Schöls, Henk J Blom, Matthis Synofzik. Hemodialysis in MNGIE transiently reduces serum and urine levels of thymidine and deoxyuridine, but not CSF levels and neurological function. Orphanet journal of rare diseases. 2017 08; 12(1):135. doi: 10.1186/s13023-017-0687-0. [PMID: 28764801]
  • Aleem Syed, Emily A Smith. Raman Imaging in Cell Membranes, Lipid-Rich Organelles, and Lipid Bilayers. Annual review of analytical chemistry (Palo Alto, Calif.). 2017 06; 10(1):271-291. doi: 10.1146/annurev-anchem-061516-045317. [PMID: 28301746]
  • Waleed A Hassanain, Emad L Izake, Arumugam Sivanesan, Godwin A Ayoko. Towards interference free HPLC-SERS for the trace analysis of drug metabolites in biological fluids. Journal of pharmaceutical and biomedical analysis. 2017 Mar; 136(?):38-43. doi: 10.1016/j.jpba.2016.12.019. [PMID: 28063334]
  • Leigh Mickelson-Young, Emily Wear, Patrick Mulvaney, Tae-Jin Lee, Eric S Szymanski, George Allen, Linda Hanley-Bowdoin, William Thompson. A flow cytometric method for estimating S-phase duration in plants. Journal of experimental botany. 2016 11; 67(21):6077-6087. doi: 10.1093/jxb/erw367. [PMID: 27697785]
  • Julianne L Holleran, Julie L Eiseman, Robert A Parise, Shivaani Kummar, Jan H Beumer. LC-MS/MS assay for the quantitation of FdCyd and its metabolites FdUrd and FU in human plasma. Journal of pharmaceutical and biomedical analysis. 2016 Sep; 129(?):359-366. doi: 10.1016/j.jpba.2016.07.027. [PMID: 27454087]
  • Xiaofeng Yin, Hirokazu Tsukaya. A pulse-chase strategy for EdU labelling assay is able to rapidly quantify cell division orientation. The New phytologist. 2016 09; 211(4):1462-9. doi: 10.1111/nph.13980. [PMID: 27121010]
  • Jienny Lee, Moon Sam Shin, Mi Ok Kim, Sunghee Jang, Sae Woong Oh, Mingyeong Kang, Kwangseon Jung, Yong Seek Park, Jongsung Lee. Apple ethanol extract promotes proliferation of human adult stem cells, which involves the regenerative potential of stem cells. Nutrition research (New York, N.Y.). 2016 09; 36(9):925-936. doi: 10.1016/j.nutres.2016.06.010. [PMID: 27632912]
  • Debanti Sengupta, Guillem Pratx. Single-Cell Characterization of 18F-FLT Uptake with Radioluminescence Microscopy. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2016 07; 57(7):1136-40. doi: 10.2967/jnumed.115.167734. [PMID: 27081170]
  • Ellen J B Derissen, Bart A W Jacobs, Alwin D R Huitema, Hilde Rosing, Jan H M Schellens, Jos H Beijnen. Exploring the intracellular pharmacokinetics of the 5-fluorouracil nucleotides during capecitabine treatment. British journal of clinical pharmacology. 2016 May; 81(5):949-57. doi: 10.1111/bcp.12877. [PMID: 26718616]
  • Anita Kazda, Svetlana Akimcheva, J Matthew Watson, Karel Riha. Cell Proliferation Analysis Using EdU Labeling in Whole Plant and Histological Samples of Arabidopsis. Methods in molecular biology (Clifton, N.J.). 2016; 1370(?):169-82. doi: 10.1007/978-1-4939-3142-2_13. [PMID: 26659962]
  • Emily E Wear, Lorenzo Concia, Ashley M Brooks, Emily A Markham, Tae-Jin Lee, George C Allen, William F Thompson, Linda Hanley-Bowdoin. Isolation of Plant Nuclei at Defined Cell Cycle Stages Using EdU Labeling and Flow Cytometry. Methods in molecular biology (Clifton, N.J.). 2016; 1370(?):69-86. doi: 10.1007/978-1-4939-3142-2_6. [PMID: 26659955]
  • Haiyang Jiang, Lei Zhao, Xiaoshen Dong, Anning He, Caiwei Zheng, Magnus Johansson, Anna Karlsson, Xinyu Zheng. Tanshinone IIA enhances bystander cell killing of cancer cells expressing Drosophila melanogaster deoxyribonucleoside kinase in nuclei and mitochondria. Oncology reports. 2015 Sep; 34(3):1487-93. doi: 10.3892/or.2015.4102. [PMID: 26134602]
  • Siyoong Seo, Kazumitsu Onizuka, Chieko Nishioka, Eiki Takahashi, Satoshi Tsuneda, Hiroshi Abe, Yoshihiro Ito. Phosphorylated 5-ethynyl-2'-deoxyuridine for advanced DNA labeling. Organic & biomolecular chemistry. 2015 Apr; 13(15):4589-95. doi: 10.1039/c5ob00199d. [PMID: 25777799]
  • Lucia Martiniova, Martha S Field, Julia L Finkelstein, Cheryll A Perry, Patrick J Stover. Maternal dietary uridine causes, and deoxyuridine prevents, neural tube closure defects in a mouse model of folate-responsive neural tube defects. The American journal of clinical nutrition. 2015 Apr; 101(4):860-9. doi: 10.3945/ajcn.114.097279. [PMID: 25833982]
  • Mickaël Bourge, Cécile Fort, Marie-Noëlle Soler, Béatrice Satiat-Jeunemaître, Spencer C Brown. A pulse-chase strategy combining click-EdU and photoconvertible fluorescent reporter: tracking Golgi protein dynamics during the cell cycle. The New phytologist. 2015 Jan; 205(2):938-50. doi: 10.1111/nph.13069. [PMID: 25266734]
  • Jianwen Wang, Guiting Lin, Amjad Alwaal, Xiaoyu Zhang, Guifang Wang, Xingyuan Jia, Lia Banie, Jacqueline Villalta, Ching-Shwun Lin, Tom F Lue. Kinetics of Label Retaining Cells in the Developing Rat Kidneys. PloS one. 2015; 10(12):e0144734. doi: 10.1371/journal.pone.0144734. [PMID: 26650841]
  • Sunil Rangarajan, Bhuvana Sunil, Chunlan Fan, Pei-Xuan Wang, Gary Cutter, Paul W Sanders, Lisa M Curtis. Distinct populations of label-retaining cells in the adult kidney are defined temporally and exhibit divergent regional distributions. American journal of physiology. Renal physiology. 2014 Dec; 307(11):F1274-82. doi: 10.1152/ajprenal.00213.2014. [PMID: 25234315]
  • Alexander N Combes, Kieran M Short, James Lefevre, Nicholas A Hamilton, Melissa H Little, Ian M Smyth. An integrated pipeline for the multidimensional analysis of branching morphogenesis. Nature protocols. 2014 Dec; 9(12):2859-79. doi: 10.1038/nprot.2014.193. [PMID: 25411953]
  • Mohd Ishtikhar, Shawez Khan, Gamal Badr, Amany Osama Mohamed, Rizwan Hasan Khan. Interaction of the 5-fluorouracil analog 5-fluoro-2'-deoxyuridine with 'N' and 'B' isoforms of human serum albumin: a spectroscopic and calorimetric study. Molecular bioSystems. 2014 Nov; 10(11):2954-64. doi: 10.1039/c4mb00306c. [PMID: 25141914]
  • Weilun Sun, Tilly Wilhelmina Aalders, Egbert Oosterwijk. Identification of potential bladder progenitor cells in the trigone. Developmental biology. 2014 Sep; 393(1):84-92. doi: 10.1016/j.ydbio.2014.06.018. [PMID: 24992712]
  • Christoph Spahn, Ulrike Endesfelder, Mike Heilemann. Super-resolution imaging of Escherichia coli nucleoids reveals highly structured and asymmetric segregation during fast growth. Journal of structural biology. 2014 Mar; 185(3):243-9. doi: 10.1016/j.jsb.2014.01.007. [PMID: 24473063]
  • Susan Mohamed, Leonardo Caporali, Roberto De Giorgio, Valerio Carelli, Manuela Contin. HPLC-UV analysis of thymidine and deoxyuridine in plasma of patients with thymidine phosphorylase deficiency. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2014 Feb; 949-950(?):58-62. doi: 10.1016/j.jchromb.2014.01.003. [PMID: 24463401]
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