Handelin (BioDeep_00000011788)

   

PANOMIX_OTCML-2023


代谢物信息卡片


[(1R,2R,3R,3aR,4S,5S,6R,6aR,9S,9aR,9bR,10S,11R)-2,6-dihydroxy-2,6,9,11-tetramethyl-6-methylidene-2,7-dioxospiro[4,5,6a,7,9a,9b-hexahydro-3aH-azuleno[4,5-b]uran-3,15-8-oxatetracyclo[9.2.2.01,10.05,9]pentadec-12-ene]-4-yl] acetate

化学式: C32H40O8 (552.2723)
中文名称: 野菊花内酯
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 82.69%

分子结构信息

SMILES: C=C1C(=O)OC2C1CCC(C)(O)C13C=CC(C)(C21)C1(C3)C(=O)OC2C3C(C)=CCC3C(C)(O)CC(OC(C)=O)C21
InChI: InChI=1S/C32H40O8/c1-15-7-8-19-21(15)24-22(20(38-17(3)33)13-29(19,5)36)32(27(35)40-24)14-31-12-11-28(32,4)25(31)23-18(9-10-30(31,6)37)16(2)26(34)39-23/h7,11-12,18-25,36-37H,2,8-10,13-14H2,1,3-6H3/t18-,19+,20-,21-,22+,23+,24+,25+,28+,29+,30+,31-,32+/m0/s1

描述信息

Handelin is a sesterterpenoid.
[(1R,2R,3R,3aR,4S,5S,6R,6aR,9S,9aR,9bR,10S,11R)-2,6-dihydroxy-2,6,9,11-tetramethyl-6-methylidene-2,7-dioxospiro[4,5,6a,7,9a,9b-hexahydro-3aH-azuleno[4,5-b]furan-3,15-8-oxatetracyclo[9.2.2.01,10.05,9]pentadec-12-ene]-4-yl] acetate is a natural product found in Tanacetum vulgare, Chrysanthemum lavandulifolium, and other organisms with data available.
Handelin is a guaianolide dimer from Chrysanthemum boreale that has potent anti-inflammatory activity by down-regulating NF-κB signaling and pro-inflammatory cytokine production[1].
Handelin is a guaianolide dimer from Chrysanthemum boreale that has potent anti-inflammatory activity by down-regulating NF-κB signaling and pro-inflammatory cytokine production[1].

同义名列表

7 个代谢物同义名

[(1R,2R,3R,3aR,4S,5S,6R,6aR,9S,9aR,9bR,10S,11R)-2,6-dihydroxy-2,6,9,11-tetramethyl-6-methylidene-2,7-dioxospiro[4,5,6a,7,9a,9b-hexahydro-3aH-azuleno[4,5-b]uran-3,15-8-oxatetracyclo[9.2.2.01,10.05,9]pentadec-12-ene]-4-yl] acetate; yejuhua lactone; Yejuhualactone; ye ju-hua; Handelin; Yejunualactone; Handelin



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 AKT1, ATG5, ELANE, FBXO32, MAPK8, MTOR, PTGS2
Peripheral membrane protein 3 ATG5, MTOR, PTGS2
Endoplasmic reticulum membrane 2 MTOR, PTGS2
Nucleus 6 AKT1, FBXO32, JUND, MAPK8, MTOR, MYOG
autophagosome 1 ATG5
cytosol 7 AKT1, ATG5, ELANE, FBXO32, IL1B, MAPK8, MTOR
dendrite 1 MTOR
phagocytic vesicle 2 ELANE, MTOR
nucleoplasm 6 AKT1, FBXO32, JUND, MAPK8, MTOR, MYOG
RNA polymerase II transcription regulator complex 1 JUND
Cell membrane 3 AKT1, CD8A, TNF
Cytoplasmic side 1 MTOR
lamellipodium 1 AKT1
Golgi apparatus membrane 1 MTOR
Synapse 1 MAPK8
cell cortex 1 AKT1
cell surface 2 ELANE, TNF
glutamatergic synapse 2 AKT1, ATG5
Golgi membrane 1 MTOR
lysosomal membrane 1 MTOR
neuronal cell body 1 TNF
postsynapse 2 AKT1, ATG5
Cytoplasm, cytosol 1 IL1B
Lysosome 2 IL1B, MTOR
plasma membrane 3 AKT1, CD8A, TNF
Membrane 3 AKT1, ATG5, MTOR
axon 2 ATG5, MAPK8
caveola 1 PTGS2
extracellular exosome 2 ELANE, MMP9
Lysosome membrane 1 MTOR
endoplasmic reticulum 1 PTGS2
extracellular space 9 CXCL1, ELANE, IGF1, IL10, IL1B, IL6, MMP9, MSTN, TNF
Schaffer collateral - CA1 synapse 1 ATG5
protein-containing complex 3 AKT1, ATG5, PTGS2
Microsome membrane 2 MTOR, PTGS2
TORC1 complex 1 MTOR
TORC2 complex 1 MTOR
Single-pass type I membrane protein 1 CD8A
Secreted 5 IGF1, IL10, IL1B, IL6, MSTN
extracellular region 9 CD8A, CXCL1, ELANE, IGF1, IL10, IL1B, IL6, MMP9, TNF
Mitochondrion outer membrane 1 MTOR
mitochondrial outer membrane 1 MTOR
[Isoform 2]: Secreted 1 CD8A
transcription regulator complex 2 JUND, MYOG
external side of plasma membrane 2 CD8A, TNF
Secreted, extracellular space, extracellular matrix 1 MMP9
Z disc 1 FBXO32
microtubule cytoskeleton 1 AKT1
cell-cell junction 1 AKT1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
vesicle 1 AKT1
Membrane raft 1 TNF
spindle 1 AKT1
Nucleus, PML body 1 MTOR
PML body 1 MTOR
Mitochondrion intermembrane space 1 AKT1
mitochondrial intermembrane space 1 AKT1
collagen-containing extracellular matrix 2 ELANE, MMP9
secretory granule 2 ELANE, IL1B
axoneme 1 ATG5
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
receptor complex 1 CD8A
neuron projection 1 PTGS2
ciliary basal body 1 AKT1
chromatin 2 JUND, MYOG
phagocytic cup 1 TNF
phagocytic vesicle membrane 1 ATG5
nuclear envelope 1 MTOR
Endomembrane system 1 MTOR
Preautophagosomal structure membrane 1 ATG5
Atg12-Atg5-Atg16 complex 1 ATG5
mitochondria-associated endoplasmic reticulum membrane contact site 1 ATG5
phagophore assembly site membrane 1 ATG5
exocytic vesicle 1 IGF1
plasma membrane raft 1 CD8A
ficolin-1-rich granule lumen 1 MMP9
endoplasmic reticulum lumen 2 IL6, PTGS2
transcription repressor complex 2 ELANE, JUND
platelet alpha granule lumen 1 IGF1
specific granule lumen 2 CXCL1, ELANE
tertiary granule lumen 2 CXCL1, MMP9
Secreted, extracellular exosome 1 IL1B
azurophil granule lumen 1 ELANE
protein-DNA complex 1 MYOG
basal dendrite 1 MAPK8
[Isoform 1]: Cell membrane 1 CD8A
Cytoplasmic vesicle, phagosome 2 ELANE, MTOR
transferase complex 1 ATG5
transcription factor AP-1 complex 1 JUND
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
T cell receptor complex 1 CD8A
alphav-beta3 integrin-IGF-1-IGF1R complex 1 IGF1
insulin-like growth factor binding protein complex 1 IGF1
insulin-like growth factor ternary complex 1 IGF1
interleukin-6 receptor complex 1 IL6
SCF ubiquitin ligase complex 1 FBXO32
phagophore 1 ATG5
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Hui-Jie Zhang, Ben-Hui Wang, Xiang Wang, Chun-Ping Huang, Si-Man Xu, Jia-Li Wang, Tian-E Huang, Wan-Li Xiao, Xiao-Li Tian, Xin-Qiang Lan, Qi-Quan Wang, Yang Xiang. Handelin alleviates cachexia- and aging-induced skeletal muscle atrophy by improving protein homeostasis and inhibiting inflammation. Journal of cachexia, sarcopenia and muscle. 2024 Feb; 15(1):173-188. doi: 10.1002/jcsm.13381. [PMID: 38009816]
  • Yuanyuan Yan, Mengfang Yang, Yuzhou Jiao, Lisha Li, Zirui Liu, Jiale Shi, Zhou Shen, Guiqing Peng. Drug screening identified that handelin inhibits feline calicivirus infection by inhibiting HSP70 expression in vitro. The Journal of general virology. 2024 Jan; 105(1):. doi: 10.1099/jgv.0.001936. [PMID: 38175184]
  • Huijie Zhang, Jiawei Qin, Xinqiang Lan, Weirong Zeng, Jing Zhou, Tian-E Huang, Wan-Li Xiao, Qi-Quan Wang, Sujiao Sun, Weiting Su, Wenhui Nie, Shan Yang, Ji Yang, Qian Gao, Yang Xiang. Handelin extends lifespan and healthspan of Caenorhabditis elegans by reducing ROS generation and improving motor function. Biogerontology. 2022 02; 23(1):115-128. doi: 10.1007/s10522-022-09950-5. [PMID: 35038074]
  • Ji Yang, Huijie Zhang, Sujiao Sun, Xue Wang, Ying Guan, Qili Mi, Wanli Zeng, Haiying Xiang, Huadong Zhu, Xin Zou, Yunfei You, Yang Xiang, Qian Gao. Autophagy and Hsp70 activation alleviate oral epithelial cell death induced by food-derived hypertonicity. Cell stress & chaperones. 2020 03; 25(2):253-264. doi: 10.1007/s12192-020-01068-2. [PMID: 31975220]
  • Pan Luo, Yanfang Cheng, Zhiyong Yin, Chanjuan Li, Jun Xu, Qiong Gu. Monomeric and Dimeric Cytotoxic Guaianolide-Type Sesquiterpenoids from the Aerial Parts of Chrysanthemum indicum. Journal of natural products. 2019 02; 82(2):349-357. doi: 10.1021/acs.jnatprod.8b00863. [PMID: 30726671]