alpha-GalCer (BioDeep_00000011468)
代谢物信息卡片
N-[(3S,4R)-3,4-dihydroxy-1-[(2S,3R,4S,5R,6R)-3,4, 5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoctadecan-2-yl]hexacosanamide
化学式: C50H99NO9 (857.7319444)
中文名称: α-半乳糖神经酰胺
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCCCCCCCCCCCCCCCCCCCCCCC(=O)NC(COC1C(C(C(C(O1)CO)O)O)O)C(C(CCCCCCCCCCCCCC)O)O
InChI: InChI=1S/C50H99NO9/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-23-24-25-26-27-29-31-33-35-37-39-45(54)51-42(41-59-50-49(58)48(57)47(56)44(40-52)60-50)46(55)43(53)38-36-34-32-30-28-16-14-12-10-8-6-4-2/h42-44,46-50,52-53,55-58H,3-41H2,1-2H3,(H,51,54)
描述信息
C308 - Immunotherapeutic Agent > C2139 - Immunostimulant
D000970 - Antineoplastic Agents
D007155 - Immunologic Factors
同义名列表
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:466659
- KEGG: C16892
- PubChem: 2826713
- PubChem: 22178808
- Metlin: METLIN64958
- DrugBank: DB12232
- ChEMBL: CHEMBL384200
- CAS: 158021-47-7
- PMhub: MS000025467
- PubChem: 135626073
- KNApSAcK: C00044850
- PDB-CCD: AGH
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 817 Bacteroides fragilis: 10.1371/JOURNAL.PBIO.1001610
- 817 Bacteroides fragilis: 10.1371/JOURNAL.PBIO.1001610
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Yanira Méndez, Aldrin V Vasco, Thomas Ebensen, Kai Schulze, Mohammad Yousefi, Mehdi Davari, Ludger A Wessjohann, Carlos A Guzmán, Daniel García Rivera, Bernhard Westermann. Diversification of a Novel α-Galactosyl Ceramide Hotspot Boosts the Adjuvant Properties in Parenteral and Mucosal Vaccines.
Angewandte Chemie (International ed. in English).
2023 Oct; ?(?):e202310983. doi:
10.1002/anie.202310983. [PMID: 37857582] - Dragica Pavlovic, Dragana Miloradovic, Milica Dimitrijevic Stojanovic, Carl Randall Harrell, Riccardo Polosa, Sonja Rust, Giovanni Li Volti, Massimo Caruso, Vladimir Jakovljevic, Valentin Djonov, Vladislav Volarevic. Cigarette smoke attenuates mesenchymal stem cell-based suppression of immune cell-driven acute liver failure.
Toxicology letters.
2023 Aug; ?(?):. doi:
10.1016/j.toxlet.2023.08.006. [PMID: 37572970] - Keita Ito, Hiroto Furukawa, Hiroshi Inaba, Shino Ohshima, Yoshie Kametani, Masatoshi Maeki, Manabu Tokeshi, Xuhao Huang, Kazuya Kabayama, Yoshiyuki Manabe, Koichi Fukase, Kazunori Matsuura. Antigen/Adjuvant-Displaying Enveloped Viral Replica as a Self-Adjuvanting Anti-Breast-Cancer Vaccine Candidate.
Journal of the American Chemical Society.
2023 07; 145(29):15838-15847. doi:
10.1021/jacs.3c02679. [PMID: 37344812] - Prashant Pandey, Seung Hyun Kim, Laxman Subedi, Khizra Mujahid, Yebon Kim, Young-Chang Cho, Jung-Hyun Shim, Ki-Taek Kim, Seung-Sik Cho, Jeong Uk Choi, Jin Woo Park. Oral lymphatic delivery of alpha-galactosylceramide and ovalbumin evokes anti-cancer immunization.
Journal of controlled release : official journal of the Controlled Release Society.
2023 Apr; 356(?):507-524. doi:
10.1016/j.jconrel.2023.03.010. [PMID: 36907564] - Roberta Manco, Luciana D'Apice, Maria Trovato, Lucia Lione, Erika Salvatori, Eleonora Pinto, Mirco Compagnone, Luigi Aurisicchio, Piergiuseppe De Berardinis, Rossella Sartorius. Co-Delivery of the Human NY-ESO-1 Tumor-Associated Antigen and Alpha-GalactosylCeramide by Filamentous Bacteriophages Strongly Enhances the Expansion of Tumor-Specific CD8+ T Cells.
Viruses.
2023 Mar; 15(3):. doi:
10.3390/v15030672. [PMID: 36992381] - Xue Cheng, Xiaosheng Tan, Wei Wang, Ziyao Zhang, Rongfei Zhu, Mi Wu, Mingyu Li, Yiqing Chen, Zhihui Liang, Peng Zhu, Xiongwen Wu, Xiufang Weng. Long-Chain Acylcarnitines Induce Senescence of Invariant Natural Killer T Cells in Hepatocellular Carcinoma.
Cancer research.
2023 02; 83(4):582-594. doi:
10.1158/0008-5472.can-22-2273. [PMID: 36512635] - Georgina V Hopkins, Stella Cochrane, David Onion, Lucy C Fairclough. Invariant NKT cells are more abundant in peanut-allergic adults and a subset of CD8+ iNKT cells are depleted after peanut oil exposure.
Frontiers in immunology.
2023; 14(?):1293158. doi:
10.3389/fimmu.2023.1293158. [PMID: 38022648] - Kazunari Ueki, Kodai Sueyoshi, Shinsuke Inuki, Yukari Fujimoto. Chemical Synthesis and Molecular Interaction Analysis of α-Galactosyl Ceramide Derivatives as CD1d Ligands.
Methods in molecular biology (Clifton, N.J.).
2023; 2613(?):13-22. doi:
10.1007/978-1-0716-2910-9_2. [PMID: 36587067] - Hashem Bayatipoor, Saber Mehdizadeh, Roghayeh Jafarpour, Zeinab Shojaei, Salar Pashangzadeh, Morteza Motallebnezhad. Role of NKT cells in cancer immunotherapy-from bench to bed.
Medical oncology (Northwood, London, England).
2022 Dec; 40(1):29. doi:
10.1007/s12032-022-01888-5. [PMID: 36460881] - Marc Caballé, Magda Faijes, Antoni Planas. Characterization of a Glycolipid Synthase Producing α-Galactosylceramide in Bacteroides fragilis.
International journal of molecular sciences.
2022 Nov; 23(22):. doi:
10.3390/ijms232213975. [PMID: 36430454] - Yeng-Nan Chen, Jung-Tung Hung, Fan-Dan Jan, Yung-Yu Su, Jih-Ru Hwu, Alice L Yu, Avijit K Adak, Chun-Cheng Lin. Diversity-Oriented Synthesis of a Molecular Library of Immunomodulatory α-Galactosylceramides with Fluorous-Tag-Assisted Purification and Evaluation of Their Bioactivities in Regard to IL-2 Secretion.
International journal of molecular sciences.
2022 Nov; 23(21):. doi:
10.3390/ijms232113403. [PMID: 36362187] - Arsenij Ustjanzew, Valentin Sencio, François Trottein, Jörg Faber, Roger Sandhoff, Claudia Paret. Interaction between Bacteria and the Immune System for Cancer Immunotherapy: The α-GalCer Alliance.
International journal of molecular sciences.
2022 May; 23(11):. doi:
10.3390/ijms23115896. [PMID: 35682578] - Jian Wang, Yu Wen, Shi-Hao Zhou, Hai-Wei Zhang, Xiao-Qian Peng, Ru-Yan Zhang, Xu-Guang Yin, Hong Qiu, Rui Gong, Guang-Fu Yang, Jun Guo. Self-Adjuvanting Lipoprotein Conjugate αGalCer-RBD Induces Potent Immunity against SARS-CoV-2 and its Variants of Concern.
Journal of medicinal chemistry.
2022 02; 65(3):2558-2570. doi:
10.1021/acs.jmedchem.1c02000. [PMID: 35073081] - Kaori Endo-Umeda, Hiroyuki Nakashima, Shigeyuki Uno, Shota Toyoshima, Naoki Umeda, Shihoko Komine-Aizawa, Shuhji Seki, Makoto Makishima. Liver X receptors regulate natural killer T cell population and antitumor activity in the liver of mice.
Scientific reports.
2021 11; 11(1):22595. doi:
10.1038/s41598-021-02062-z. [PMID: 34799646] - Yiping Chen, Yiping Zhu, Geng Su, Wei Yang, Yanying Zhao, Weiwei Lu, Jinghong Zhang. KRN7000 Reduces Airway Inflammation via Natural Killer T Cells in Obese Asthmatic Mice.
Inflammation.
2021 Oct; 44(5):1982-1992. doi:
10.1007/s10753-021-01475-2. [PMID: 34021838] - Xi-Feng Wang, Meng-Jia Zhang, Na He, Ya-Cong Wang, Cheng Yan, Xiang-Zhao Chen, Xiao-Fei Gao, Jun Guo, Rui Luo, Zheng Liu. Potent Neutralizing Antibodies Elicited by RBD-Fc-Based COVID-19 Vaccine Candidate Adjuvanted by the Th2-Skewing iNKT Cell Agonist.
Journal of medicinal chemistry.
2021 08; 64(15):11554-11569. doi:
10.1021/acs.jmedchem.1c00881. [PMID: 34279930] - Xu-Guang Yin, Jie Lu, Jian Wang, Ru-Yan Zhang, Xi-Feng Wang, Chun-Miao Liao, Xiao-Peng Liu, Zheng Liu, Jun Guo. Synthesis and Evaluation of Liposomal Anti-GM3 Cancer Vaccine Candidates Covalently and Noncovalently Adjuvanted by αGalCer.
Journal of medicinal chemistry.
2021 02; 64(4):1951-1965. doi:
10.1021/acs.jmedchem.0c01186. [PMID: 33539088] - Renée Poels, Esther Drent, Roeland Lameris, Afroditi Katsarou, Maria Themeli, Hans J van der Vliet, Tanja D de Gruijl, Niels W C J van de Donk, Tuna Mutis. Preclinical Evaluation of Invariant Natural Killer T Cells Modified with CD38 or BCMA Chimeric Antigen Receptors for Multiple Myeloma.
International journal of molecular sciences.
2021 Jan; 22(3):. doi:
10.3390/ijms22031096. [PMID: 33499253] - Joshua Choi, Tina S Mele, Steven A Porcelli, Paul B Savage, S M Mansour Haeryfar. Harnessing the Versatility of Invariant NKT Cells in a Stepwise Approach to Sepsis Immunotherapy.
Journal of immunology (Baltimore, Md. : 1950).
2021 01; 206(2):386-397. doi:
10.4049/jimmunol.2000220. [PMID: 33310870] - Patrick T Rudak, S M Mansour Haeryfar. In Vivo Cytotoxicity by α-GalCer-transactivated NK Cells.
Methods in molecular biology (Clifton, N.J.).
2021; 2388(?):157-174. doi:
10.1007/978-1-0716-1775-5_15. [PMID: 34524671] - Dongzhi Chen, Wenbin Xu, Jingfang Teng, Huifang Liu, Yuanyuan Wang, Yan Wang, Shujie Cheng, Ming Meng. Migration, Distribution, and Safety Evaluation of Specific Phenotypic and Functional Mouse Spleen-Derived Invariant Natural Killer T2 Cells after Adoptive Infusion.
Mediators of inflammation.
2021; 2021(?):5170123. doi:
10.1155/2021/5170123. [PMID: 34924812] - Letícia S Martins, Evandro L Duarte, M Teresa Lamy, Julio H K Rozenfeld. Supramolecular organization of α-galactosylceramide in pure dispersions and in cationic DODAB bilayers.
Chemistry and physics of lipids.
2020 10; 232(?):104963. doi:
10.1016/j.chemphyslip.2020.104963. [PMID: 32882224] - Taku Aiga, Yoshiyuki Manabe, Keita Ito, Tsung-Che Chang, Kazuya Kabayama, Shino Ohshima, Yoshie Kametani, Ayane Miura, Hiroto Furukawa, Hiroshi Inaba, Kazunori Matsuura, Koichi Fukase. Immunological Evaluation of Co-Assembling a Lipidated Peptide Antigen and Lipophilic Adjuvants: Self-Adjuvanting Anti-Breast-Cancer Vaccine Candidates.
Angewandte Chemie (International ed. in English).
2020 09; 59(40):17705-17711. doi:
10.1002/anie.202007999. [PMID: 32583549] - Shinsuke Inuki, Natsumi Hirata, Emi Kashiwabara, Junichiro Kishi, Toshihiko Aiba, Toshiaki Teratani, Wataru Nakamura, Yoshimi Kojima, Toru Maruyama, Takanori Kanai, Yukari Fujimoto. Polar functional group-containing glycolipid CD1d ligands modulate cytokine-biasing responses and prevent experimental colitis.
Scientific reports.
2020 09; 10(1):15766. doi:
10.1038/s41598-020-72280-4. [PMID: 32978421] - Lu Wang, Zhilan Liu, Lili Wang, Qielan Wu, Xiang Li, Di Xie, Huimin Zhang, Yongdeng Zhang, Lusheng Gu, Yanhong Xue, Ting Yue, Gang Liu, Wei Ji, Haiming Wei, Tao Xu, Li Bai. Spatial distribution of IL4 controls iNKT cell-DC crosstalk in tumors.
Cellular & molecular immunology.
2020 05; 17(5):496-506. doi:
10.1038/s41423-019-0243-z. [PMID: 31160756] - Saikiran K Sedimbi, Thomas Hägglöf, Manasa G Garimella, Shan Wang, Amanda Duhlin, Ana Coelho, Katrine Ingelshed, Emma Mondoc, Stephen G Malin, Rikard Holmdahl, David P Lane, Elizabeth A Leadbetter, Mikael C I Karlsson. Combined proinflammatory cytokine and cognate activation of invariant natural killer T cells enhances anti-DNA antibody responses.
Proceedings of the National Academy of Sciences of the United States of America.
2020 04; 117(16):9054-9063. doi:
10.1073/pnas.1920463117. [PMID: 32295878] - Sicheng Fu, Kaixin He, Chenxi Tian, Hua Sun, Chenwen Zhu, Shiyu Bai, Jiwei Liu, Qielan Wu, Di Xie, Ting Yue, Zhuxia Shen, Qingqing Dai, Xiaojun Yu, Shu Zhu, Gang Liu, Rongbin Zhou, Shengzhong Duan, Zhigang Tian, Tao Xu, Hua Wang, Li Bai. Impaired lipid biosynthesis hinders anti-tumor efficacy of intratumoral iNKT cells.
Nature communications.
2020 01; 11(1):438. doi:
10.1038/s41467-020-14332-x. [PMID: 31974378] - Gerald Brezesinski, Adam D J Calow, Claney L Pereira, Peter H Seeberger. Thermodynamic and Structural Behavior of α-Galactosylceramide and C6-Functionalized α-GalCer in 2D Layers at the Air-Liquid Interface.
Chembiochem : a European journal of chemical biology.
2020 01; 21(1-2):241-247. doi:
10.1002/cbic.201900491. [PMID: 31544285] - Kazuhito Ishii, Masumi Shimizu, Hideki Kogo, Yasuyuki Negishi, Hideto Tamura, Rimpei Morita, Hidemi Takahashi. A combination of check-point blockade and α-galactosylceramide elicits long-lasting suppressive effects on murine hepatoma cell growth in vivo.
Immunobiology.
2020 01; 225(1):151860. doi:
10.1016/j.imbio.2019.10.009. [PMID: 31812347] - Jun-Ichi Kashiwakura, Kodai Saitoh, Takeru Ihara, Yuto Sasaki, Kota Kagohashi, Shiyo Enohara, Yuka Morioka, Hiroshi Watarai, Ryuta Muromoto, Yuichi Kitai, Kazuya Iwabuchi, Kenji Oritani, Tadashi Matsuda. Expression of signal-transducing adaptor protein-1 attenuates experimental autoimmune hepatitis via down-regulating activation and homeostasis of invariant natural killer T cells.
PloS one.
2020; 15(11):e0241440. doi:
10.1371/journal.pone.0241440. [PMID: 33175848] - Ying Wang, Madhura S Bhave, Hideo Yagita, Susanna L Cardell. Natural Killer T-Cell Agonist α-Galactosylceramide and PD-1 Blockade Synergize to Reduce Tumor Development in a Preclinical Model of Colon Cancer.
Frontiers in immunology.
2020; 11(?):581301. doi:
10.3389/fimmu.2020.581301. [PMID: 33193386] - Nathan G F Leborgne, Adriano Taddeo, Stefan Freigang, Charaf Benarafa. Serpinb1a Is Dispensable for the Development and Cytokine Response of Invariant Natural Killer T Cell Subsets.
Frontiers in immunology.
2020; 11(?):562587. doi:
10.3389/fimmu.2020.562587. [PMID: 33262755] - Dorian A Stolk, Aram de Haas, Jana Vree, Sanne Duinkerken, Joyce Lübbers, Rieneke van de Ven, Martino Ambrosini, Hakan Kalay, Sven Bruijns, Hans J van der Vliet, Tanja D de Gruijl, Yvette van Kooyk. Lipo-Based Vaccines as an Approach to Target Dendritic Cells for Induction of T- and iNKT Cell Responses.
Frontiers in immunology.
2020; 11(?):990. doi:
10.3389/fimmu.2020.00990. [PMID: 32536918] - Janice M H Cheng, Stephanie H Chee, Yusuf Dölen, Martijn Verdoes, Mattie S M Timmer, Bridget L Stocker. An efficient synthesis of a 6″-BODIPY-α-Galactosylceramide probe for monitoring α-Galactosylceramide uptake by cells.
Carbohydrate research.
2019 Dec; 486(?):107840. doi:
10.1016/j.carres.2019.107840. [PMID: 31689579] - Catarina F Almeida, Srinivasan Sundararaj, Jérôme Le Nours, T Praveena, Benjamin Cao, Satvika Burugupalli, Dylan G M Smith, Onisha Patel, Manfred Brigl, Daniel G Pellicci, Spencer J Williams, Adam P Uldrich, Dale I Godfrey, Jamie Rossjohn. Distinct CD1d docking strategies exhibited by diverse Type II NKT cell receptors.
Nature communications.
2019 11; 10(1):5242. doi:
10.1038/s41467-019-12941-9. [PMID: 31748533] - Johanna von Gerichten, Dominic Lamprecht, Lukáš Opálka, Daphnée Soulard, Christian Marsching, Robert Pilz, Valentin Sencio, Silke Herzer, Bruno Galy, Viola Nordström, Carsten Hopf, Hermann-Josef Gröne, François Trottein, Roger Sandhoff. Bacterial immunogenic α-galactosylceramide identified in the murine large intestine: dependency on diet and inflammation.
Journal of lipid research.
2019 11; 60(11):1892-1904. doi:
10.1194/jlr.ra119000236. [PMID: 31484693] - Rotonya M Carr. α-Galactosylceramide: a potent immunomodulator produced by gut microbes.
Journal of lipid research.
2019 11; 60(11):1805-1806. doi:
10.1194/jlr.c119000437. [PMID: 31575643] - Yingyu Qin, Sejin Oh, Sojung Lim, Jung Hoon Shin, Min Sang Yoon, Se-Ho Park. Invariant NKT cells facilitate cytotoxic T-cell activation via direct recognition of CD1d on T cells.
Experimental & molecular medicine.
2019 10; 51(10):1-9. doi:
10.1038/s12276-019-0329-9. [PMID: 31653827] - Dongzhi Chen, Xiang Gao, Jianguo Wang, Huijuan Zhao, Huifang Liu, Shengde Chen, Jingnan Zhang, Ming Meng. Activation of hepatic iNKT2 cells by α-GalCer ameliorates hepatic steatosis induced by high-fat diet in C57BL/6J mice.
International immunopharmacology.
2019 Sep; 74(?):105727. doi:
10.1016/j.intimp.2019.105727. [PMID: 31284229] - Tae-Jin Kim, Gayoung Park, Jeongmin Kim, Seon Ah Lim, Jiyoung Kim, Kyungtaek Im, Min Hwa Shin, Yang-Xin Fu, Maria-Luisa Del Rio, Jose-Ignacio Rodriguez-Barbosa, Cassian Yee, Kyung-Suk Suh, Seong-Jin Kim, Sang-Jun Ha, Kyung-Mi Lee. CD160 serves as a negative regulator of NKT cells in acute hepatic injury.
Nature communications.
2019 07; 10(1):3258. doi:
10.1038/s41467-019-10320-y. [PMID: 31332204] - Satoshi Suzuki, Daiju Sakurai, Toshioki Sakurai, Syuji Yonekura, Tomohisa Iinuma, Yusuke Okuma, Fumie Ihara, Tomoyuki Arai, Toyoyuki Hanazawa, Emi Fukuda-Kawaguchi, Yasuyuki Ishii, Yoshitaka Okamoto. Sublingual administration of liposomes enclosing alpha-galactosylceramide as an effective adjuvant of allergen immunotherapy in a murine model of allergic rhinitis.
Allergology international : official journal of the Japanese Society of Allergology.
2019 Jul; 68(3):352-362. doi:
10.1016/j.alit.2019.02.003. [PMID: 30803854] - Binbin Song, Shigeki Aoki, Cong Liu, Kousei Ito. A toll-like receptor 9 agonist sensitizes mice to mitochondrial dysfunction-induced hepatic apoptosis via the Fas/FasL pathway.
Archives of toxicology.
2019 06; 93(6):1573-1584. doi:
10.1007/s00204-019-02454-1. [PMID: 30993380] - Junichiro Kishi, Shinsuke Inuki, Natsumi Hirata, Emi Kashiwabara, Daisuke Yoshidome, Osamu Ichihara, Yukari Fujimoto. Structure-activity relationship studies of Bz amide-containing α-GalCer derivatives as natural killer T cell modulators.
Bioorganic & medicinal chemistry letters.
2019 04; 29(8):970-973. doi:
10.1016/j.bmcl.2019.02.018. [PMID: 30824201] - Xiang-Zhao Chen, Ru-Yan Zhang, Xi-Feng Wang, Xu-Guang Yin, Jian Wang, Ya-Cong Wang, Xiu Liu, Jing-Jing Du, Zheng Liu, Jun Guo. Peptide-free Synthetic Nicotine Vaccine Candidates with α-Galactosylceramide as Adjuvant.
Molecular pharmaceutics.
2019 04; 16(4):1467-1476. doi:
10.1021/acs.molpharmaceut.8b01095. [PMID: 30821985] - Peng He, Chuanfang Zhao, Jiao Lu, Yang Zhang, Min Fang, Yuguo Du. Synthesis of 5-Thio-α-GalCer Analogues with Fluorinated Acyl Chain on Lipid Residue and Their Biological Evaluation.
ACS medicinal chemistry letters.
2019 Feb; 10(2):221-225. doi:
10.1021/acsmedchemlett.8b00640. [PMID: 30783507] - Katharine Clark, Jessica Yau, Anja Bloom, Jing Wang, David J Venzon, Motoshi Suzuki, Lise Pasquet, Benjamin J Compton, Susanna L Cardell, Steven A Porcelli, Gavin F Painter, Dirk M Zajonc, Jay A Berzofsky, Masaki Terabe. Structure-Function Implications of the Ability of Monoclonal Antibodies Against α-Galactosylceramide-CD1d Complex to Recognize β-Mannosylceramide Presentation by CD1d.
Frontiers in immunology.
2019; 10(?):2355. doi:
10.3389/fimmu.2019.02355. [PMID: 31649670] - Daniel G Pellicci, Adam P Uldrich. Unappreciated diversity within the pool of CD1d-restricted T cells.
Seminars in cell & developmental biology.
2018 12; 84(?):42-47. doi:
10.1016/j.semcdb.2017.11.031. [PMID: 29183709] - C S Pereira, H Ribeiro, B Pérez-Cabezas, M T Cardoso, N Alegrete, A Gaspar, E Leão-Teles, M F Macedo. The GM2 ganglioside inhibits iNKT cell responses in a CD1d-dependent manner.
Molecular genetics and metabolism.
2018 09; 125(1-2):161-167. doi:
10.1016/j.ymgme.2018.07.005. [PMID: 30030044] - Takahiro Uchida, Hiroyuki Nakashima, Seigo Ito, Takuya Ishikiriyama, Masahiro Nakashima, Shuhji Seki, Hiroo Kumagai, Naoki Oshima. Activated natural killer T cells in mice induce acute kidney injury with hematuria through possibly common mechanisms shared by human CD56+ T cells.
American journal of physiology. Renal physiology.
2018 09; 315(3):F618-F627. doi:
10.1152/ajprenal.00160.2018. [PMID: 29993279] - Vanessa Sainz, Liane I F Moura, Carina Peres, Ana I Matos, Ana S Viana, Angela M Wagner, Julia E Vela Ramirez, Teresa S Barata, Manuela Gaspar, Steve Brocchini, Mire Zloh, Nicholas A Peppas, Ronit Satchi-Fainaro, Helena F Florindo. α-Galactosylceramide and peptide-based nano-vaccine synergistically induced a strong tumor suppressive effect in melanoma.
Acta biomaterialia.
2018 08; 76(?):193-207. doi:
10.1016/j.actbio.2018.06.029. [PMID: 29940370] - Fan Zhang, Sirkka B Stephan, Chibawanye I Ene, Tyrel T Smith, Eric C Holland, Matthias T Stephan. Nanoparticles That Reshape the Tumor Milieu Create a Therapeutic Window for Effective T-cell Therapy in Solid Malignancies.
Cancer research.
2018 07; 78(13):3718-3730. doi:
10.1158/0008-5472.can-18-0306. [PMID: 29760047] - Takahiro Uchida, Hiroyuki Nakashima, Akira Yamagata, Seigo Ito, Takuya Ishikiriyama, Masahiro Nakashima, Shuhji Seki, Hiroo Kumagai, Naoki Oshima. Repeated administration of alpha-galactosylceramide ameliorates experimental lupus nephritis in mice.
Scientific reports.
2018 05; 8(1):8225. doi:
10.1038/s41598-018-26470-w. [PMID: 29844470] - Marina Gazdic, Bojana Simovic Markovic, Aleksandar Arsenijevic, Nemanja Jovicic, Aleksandar Acovic, C Randall Harrell, Crissy Fellabaum, Valentin Djonov, Nebojsa Arsenijevic, Miodrag L Lukic, Vladislav Volarevic. Crosstalk between mesenchymal stem cells and T regulatory cells is crucially important for the attenuation of acute liver injury.
Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.
2018 05; 24(5):687-702. doi:
10.1002/lt.25049. [PMID: 29500914] - K Oleinika, E C Rosser, D E Matei, K Nistala, A Bosma, I Drozdov, C Mauri. CD1d-dependent immune suppression mediated by regulatory B cells through modulations of iNKT cells.
Nature communications.
2018 02; 9(1):684. doi:
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