Aplysiatoxin (BioDeep_00000011388)

   


代谢物信息卡片


(1S,3R,4S,9R,13S,14R)-3-[(2S,5S)-5-(2-bromo-5-hydroxyphenyl)-5-methoxypentan-2-yl]-13-hydroxy-9-[(1R)-1-hydroxyethyl]-4,14,16,16-tetramethyl-2,6,10,17-tetraoxatricyclo[11.3.1.11,5]octadecane-7,11-dione

化学式: C32H47BrO10 (670.2352422)
中文名称:
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC1CC(C23CC(C(C(O2)C(C)CCC(C4=C(C=CC(=C4)O)Br)OC)C)OC(=O)CC(OC(=O)CC1(O3)O)C(C)O)(C)C
InChI: InChI=1S/C32H47BrO10/c1-17(8-11-24(39-7)22-12-21(35)9-10-23(22)33)29-19(3)26-15-32(42-29)30(5,6)14-18(2)31(38,43-32)16-28(37)40-25(20(4)34)13-27(36)41-26/h9-10,12,17-20,24-26,29,34-35,38H,8,11,13-16H2,1-7H3/t17-,18+,19-,20+,24-,25+,26?,29+,31-,32-/m0/s1

描述信息

The parent member of the class of aplysiatoxins. It is a cyanotoxin produced by several species of freshwater and marine cyanobacteria, as well as algae and molluscs.
D009676 - Noxae > D011042 - Poisons > D008235 - Lyngbya Toxins
D009676 - Noxae > D011042 - Poisons > D008387 - Marine Toxins

同义名列表

2 个代谢物同义名

(1S,3R,4S,9R,13S,14R)-3-[(2S,5S)-5-(2-bromo-5-hydroxyphenyl)-5-methoxypentan-2-yl]-13-hydroxy-9-[(1R)-1-hydroxyethyl]-4,14,16,16-tetramethyl-2,6,10,17-tetraoxatricyclo[11.3.1.11,5]octadecane-7,11-dione; Aplysiatoxin



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

6 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yusuke Hanaki, Masayuki Kikumori, Harukuni Tokuda, Mutsumi Okamura, Shingo Dan, Naoko Adachi, Naoaki Saito, Ryo C Yanagita, Kazuhiro Irie. Loss of the Phenolic Hydroxyl Group and Aromaticity from the Side Chain of Anti-Proliferative 10-Methyl-aplog-1, a Simplified Analog of Aplysiatoxin, Enhances Its Tumor-Promoting and Proinflammatory Activities. Molecules (Basel, Switzerland). 2017 Apr; 22(4):. doi: 10.3390/molecules22040631. [PMID: 28406454]
  • K L Marshall, R L Vogt. Illness associated with eating seaweed, Hawaii, 1994. The Western journal of medicine. 1998 Nov; 169(5):293-5. doi: ". [PMID: 9830364]
  • K Ohuchi, T Sugawara, M Watanabe, N Hirasawa, S Tsurufuji, H Fujiki, S B Christensen, T Sugimura. Analysis of the stimulative effect of thapsigargin, a non-TPA-type tumour promoter, on arachidonic acid metabolism in rat peritoneal macrophages. British journal of pharmacology. 1988 Jul; 94(3):917-23. doi: 10.1111/j.1476-5381.1988.tb11604.x. [PMID: 3140994]
  • H Brockerhoff. Membrane protein-lipid hydrogen bonding: evidence from protein kinase C, diglyceride, and tumor promotors. FEBS letters. 1986 May; 201(1):1-4. doi: 10.1016/0014-5793(86)80559-2. [PMID: 3086122]
  • H Fujiki. [The actions of TPA-type as well as non-TPA type tumor promoters and their mechanism(s) in tumor promotion]. Gan to kagaku ryoho. Cancer & chemotherapy. 1986 Mar; 13(3 Pt 2):758-65. doi: . [PMID: 2870684]
  • Y Keisari, I Geva, E Flescher, H Goldin, G Lavie. Stimulation of human monocyte oxidative burst and related cytotoxicity by tumor-promoting and non-tumor-promoting diterpene esters, indole alkaloids and polyacetate-type agents. International journal of cancer. 1985 Oct; 36(4):467-72. doi: 10.1002/ijc.2910360409. [PMID: 3930412]
  • E G Fey, S Penman. Tumor promoters induce a specific morphological signature in the nuclear matrix-intermediate filament scaffold of Madin-Darby canine kidney (MDCK) cell colonies. Proceedings of the National Academy of Sciences of the United States of America. 1984 Jul; 81(14):4409-13. doi: 10.1073/pnas.81.14.4409. [PMID: 6431407]
  • A D Horowitz, H Fujiki, I B Weinstein, A Jeffrey, E Okin, R E Moore, T Sugimura. Comparative effects of aplysiatoxin, debromoaplysiatoxin, and teleocidin on receptor binding and phospholipid metabolism. Cancer research. 1983 Apr; 43(4):1529-35. doi: . [PMID: 6299522]