RUBRATOXIN B (BioDeep_00000011386)

   


代谢物信息卡片


1H-Cyclonona[1,2-c:5,6-c]difuran-1,3,6,8(4H)-tetrone,10-[(R)-[(2R)-3,6-dihydro-6-oxo-2H-pyran-2-yl]hydroxymethyl]-5,9,10,11-tetrahydro-4-hydroxy-5-[(1S)-1-hydroxyheptyl]-,(4S,5R,10R)-rel-(+)-

  化学式: C26H30O11 (518.1788)
中文名称: 红青霉毒素 B
  谱图信息: 最多检出来源 Viridiplantae(plant) 9.52%

分子结构信息

SMILES: CCCCCCC(=O)C1C2=C(CC(C(O)CCC=CC(=O)O)CC3=C(C(=O)OC3=O)C1O)C(=O)OC2=O
InChI: InChI=1S/C26H30O11/c1-2-3-4-5-7-15(27)20-18-13(23(31)36-25(18)33)10-12(21(29)16-8-6-9-17(28)35-16)11-14-19(22(20)30)26(34)37-24(14)32/h6,9,12,15-16,20-22,27,29-30H,2-5,7-8,10-11H2,1H3/t12-,15+,16-,20+,21-,22-/m0/s1



数据库引用编号

10 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 AIMP2, ALB, CASP3, CASP7, CCL3, CCL5, CYP1A1, MAPK8, MAPK9
Peripheral membrane protein 1 CYP1A1
Endoplasmic reticulum membrane 2 CYP1A1, HSP90B1
Nucleus 9 AIMP2, ALB, CASP3, CASP7, CYC1, HSP90B1, JUN, MAPK8, MAPK9
cytosol 9 AIMP2, ALB, CASP3, CASP7, CCL3, GPT, HSP90B1, MAPK8, MAPK9
centrosome 1 ALB
nucleoplasm 5 CASP3, CASP7, JUN, MAPK8, MAPK9
RNA polymerase II transcription regulator complex 1 JUN
Cell membrane 1 TNF
Multi-pass membrane protein 1 CACNA1I
Synapse 1 MAPK8
cell surface 1 TNF
glutamatergic synapse 1 CASP3
Golgi apparatus 2 ALB, IGFBP1
mitochondrial inner membrane 2 CYC1, CYP1A1
neuronal cell body 2 CASP3, TNF
smooth endoplasmic reticulum 1 HSP90B1
Cytoplasm, cytosol 2 AIMP2, CASP7
plasma membrane 4 CACNA1I, CSF2, MAPK9, TNF
Membrane 4 AIMP2, CACNA1I, CYC1, HSP90B1
axon 1 MAPK8
extracellular exosome 3 ALB, GPT, HSP90B1
endoplasmic reticulum 2 ALB, HSP90B1
extracellular space 10 ALB, CASP7, CCL2, CCL3, CCL4, CCL5, CSF2, CXCL8, IGFBP1, TNF
perinuclear region of cytoplasm 1 HSP90B1
Schaffer collateral - CA1 synapse 1 MAPK9
mitochondrion 3 CYC1, CYP1A1, MAPK9
protein-containing complex 2 ALB, HSP90B1
intracellular membrane-bounded organelle 2 CSF2, CYP1A1
Microsome membrane 1 CYP1A1
postsynaptic density 1 CASP3
Secreted 7 ALB, CCL2, CCL3, CCL5, CSF2, CXCL8, IGFBP1
extracellular region 10 ALB, CCL2, CCL3, CCL4, CCL5, CSF2, CXCL8, HSP90B1, IGFBP1, TNF
Single-pass membrane protein 1 CYC1
anchoring junction 1 ALB
transcription regulator complex 1 JUN
external side of plasma membrane 1 TNF
midbody 1 HSP90B1
recycling endosome 1 TNF
Single-pass type II membrane protein 1 TNF
Mitochondrion inner membrane 2 CYC1, CYP1A1
Membrane raft 1 TNF
focal adhesion 1 HSP90B1
collagen-containing extracellular matrix 1 HSP90B1
nuclear speck 1 MAPK9
ciliary basal body 1 ALB
chromatin 1 JUN
phagocytic cup 1 TNF
centriole 1 ALB
Secreted, extracellular space 1 CASP7
spindle pole 1 ALB
nuclear chromosome 1 JUN
blood microparticle 1 ALB
Melanosome 1 HSP90B1
euchromatin 1 JUN
sperm plasma membrane 1 HSP90B1
endoplasmic reticulum lumen 3 ALB, HSP90B1, IGFBP1
platelet alpha granule lumen 1 ALB
voltage-gated calcium channel complex 1 CACNA1I
respiratory chain complex III 1 CYC1
Sarcoplasmic reticulum lumen 1 HSP90B1
basal dendrite 1 MAPK8
death-inducing signaling complex 1 CASP3
aminoacyl-tRNA synthetase multienzyme complex 1 AIMP2
granulocyte macrophage colony-stimulating factor receptor complex 1 CSF2
endocytic vesicle lumen 1 HSP90B1
transcription factor AP-1 complex 1 JUN
[Tumor necrosis factor, soluble form]: Secreted 1 TNF
endoplasmic reticulum chaperone complex 1 HSP90B1
ciliary transition fiber 1 ALB
[C-domain 2]: Secreted 1 TNF
[Tumor necrosis factor, membrane form]: Membrane 1 TNF
[C-domain 1]: Secreted 1 TNF


文献列表

  • Keiko Iwashita, Hitoshi Nagashima. Rubratoxin B induces signs of fatty acid oxidation disorders (FAODs) in mice. Toxicology letters. 2011 Oct; 206(2):238-43. doi: 10.1016/j.toxlet.2011.07.027. [PMID: 21835235]
  • V Sava, D Mosquera, S Song, T Stedeford, K Calero, F Cardozo-Pelaez, R Harbison, J Sanchez-Ramos. Rubratoxin B elicits antioxidative and DNA repair responses in mouse brain. Gene expression. 2004; 11(5-6):211-9. doi: 10.3727/000000003783992261. [PMID: 15200233]
  • N H Aziz, S S Abdel-Aal. Regulation of rubratoxin-B biosynthesis: assessment of role of gamma-irradiation, pH and carbohydrates. Microbios. 1997; 89(358):47-54. doi: . [PMID: 9254332]
  • J A Engelhardt, W W Carlton, E J Hinsman, A W Hayes. Rubratoxin B mycotoxicosis in the Syrian hamster: ultrastructural alterations. Experimental and molecular pathology. 1989 Apr; 50(2):193-204. doi: 10.1016/0014-4800(89)90030-0. [PMID: 2707382]
  • J R Thurston, J M Sacks, J L Richard, W M Peden, K Driftmier. Complement, bacteriostatic, and enzymatic activities in sera from guinea pigs given aflatoxin and/or rubratoxin. American journal of veterinary research. 1989 Mar; 50(3):356-8. doi: . [PMID: 2648903]
  • J A Engelhardt, W W Carlton, G P Carlson, A W Hayes. Reduction of hepatic and renal nonprotein sulfhydryl content and increased toxicity of rubratoxin B in the Syrian hamster and Mongolian gerbil. Toxicology and applied pharmacology. 1988 Oct; 96(1):85-92. doi: 10.1016/0041-008x(88)90250-5. [PMID: 3188028]
  • A M Abdelhamid. Physionutritional effects of rubratoxin-B on rabbits. Archiv fur Tierernahrung. 1988 Sep; 38(9):825-32. doi: 10.1080/17450398809430910. [PMID: 3214267]
  • J A Engelhardt, W W Carlton, A H Rebar, A W Hayes. Rubratoxin B mycotoxicosis in the Swiss ICR mouse. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1988 May; 26(5):459-66. doi: 10.1016/0278-6915(88)90058-0. [PMID: 3391470]
  • J A Engelhardt, W W Carlton, A H Rebar, A W Hayes. Rubratoxin B mycotoxicosis in the Mongolian gerbil. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1987 Nov; 25(11):843-53. doi: 10.1016/0278-6915(87)90263-8. [PMID: 2961671]
  • J A Engelhardt, W W Carlton, A H Rebar, A W Hayes. Rubratoxin B mycotoxicosis in the Syrian hamster. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 1987 Sep; 25(9):685-95. doi: 10.1016/0278-6915(87)90102-5. [PMID: 3653822]