Nornitrogen mustard (BioDeep_00000011260)
Secondary id: BioDeep_00001874613
human metabolite Endogenous blood metabolite
代谢物信息卡片
化学式: C4H9Cl2N (141.0112)
中文名称: 双（2-氯乙基）胺
谱图信息:
最多检出来源 Homo sapiens(blood) 29.41%
分子结构信息
SMILES: C(CCl)NCCCl
InChI: InChI=1S/C4H9Cl2N/c5-1-3-7-4-2-6/h7H,1-4H2
描述信息
Nornitrogen mustard is a metabolite of cyclophosphamide. Cyclophosphamide (trade names Endoxan, Cytoxan, Neosar, Procytox, Revimmune), also known as cytophosphane, is a nitrogen mustard alkylating agent, from the oxazophorines group. An alkylating agent adds an alkyl group (CnH2n+1) to DNA. It attaches the alkyl group to the guanine base of DNA, at the number 7 nitrogen atom of the imidazole ring. It is used to treat various types of cancer and some autoimmune disorders. (Wikipedia)
D000970 - Antineoplastic Agents > D018906 - Antineoplastic Agents, Alkylating > D009588 - Nitrogen Mustard Compounds
同义名列表
12 个代谢物同义名
Nornitrogen mustard, hydrochloride; Nornitrogen mustard, hydrobromide; Nornitrogen mustard, hydroiodide; 2,2-Dichlorodiethylamine; Bis(2-chloroethyl)amine; Bis(chloroethyl)amine; Nor-nitrogen mustard; Nornitrogen mustard; Nor-N-mustard; NH-Lost; Nornitrogen mustard; Bis(2-chloroethyl)amine
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:37599
- KEGG: C16552
- PubChem: 9533
- HMDB: HMDB0060688
- Metlin: METLIN635
- ChEMBL: CHEMBL913
- CAS: 334-22-5
- PMhub: MS000025232
- PubChem: 51090881
- NIKKAJI: J126.297A
- KNApSAcK: 37599
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
2 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(2)
- Cyclophosphamide Action Pathway:
Aldophosphamide + Glutathione ⟶ 4-Glutathionyl cyclophosphamide + Water - Cyclophosphamide Metabolism Pathway:
Aldophosphamide + Glutathione ⟶ 4-Glutathionyl cyclophosphamide + Water
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- E E Mayatskaya, A V Semeikin, V M Rzheznikov, N L Shimanovskii. Binding of bis-beta-chloroethylamine derivatives of synthetic estrogens to proteins: dependence on the chemical structure.
Bulletin of experimental biology and medicine.
2002 Dec; 134(6):544-7. doi:
10.1023/a:1022900826174. [PMID: 12660833] - Daan Noort, Albert G Hulst, Rob Jansen. Covalent binding of nitrogen mustards to the cysteine-34 residue in human serum albumin.
Archives of toxicology.
2002 Mar; 76(2):83-8. doi:
10.1007/s00204-001-0318-2. [PMID: 11914777] - H Lu, K K Chan. Gas chromatographic-mass spectrometric assay for N-2-chloroethylaziridine, a volatile cytotoxic metabolite of cyclophosphamide, in rat plasma.
Journal of chromatography. B, Biomedical applications.
1996 Apr; 678(2):219-25. doi:
10.1016/0378-4347(95)00528-5. [PMID: 8738025] - G Momerency, K Van Cauwenberghe, P H Slee, A T Van Oosterom, E A De Bruijn. The determination of cyclophosphamide and its metabolites in blood plasma as stable trifluoroacetyl derivatives by electron capture chemical ionization gas chromatography/mass spectrometry.
Biological mass spectrometry.
1994 Mar; 23(3):149-58. doi:
10.1002/bms.1200230306. [PMID: 8148406] - I Jardine, C Fenselau, M Appler, M N Kan, R B Brundrett, M Colvin. Quantitation by gas chromatography-chemical ionization mass spectrometry of cyclophosphamide, phosphoramide mustard, and nornitrogen mustard in the plasma and urine of patients receiving cyclophosphamide therapy.
Cancer research.
1978 Feb; 38(2):408-15. doi:
. [PMID: 620410]
