Methylurea (BioDeep_00000011139)

 

Secondary id: BioDeep_00001871787

human metabolite blood metabolite


代谢物信息卡片


N-methylcarbamimidic acid

化学式: C2H6N2O (74.0480106)
中文名称: 甲基脲
谱图信息: 最多检出来源 Homo sapiens(blood) 61.36%

分子结构信息

SMILES: CNC(=N)O
InChI: InChI=1S/C2H6N2O/c1-4-2(3)5/h1H3,(H3,3,4,5)

描述信息

同义名列表

7 个代谢物同义名

N-methylcarbamimidic acid; methylharnstoff; Monomethylurea; 1-Methylurea; N-Methylurea; Methyl urea; METHYLUREA



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(1)

PlantCyc(0)

代谢反应

1 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(1)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Nicolai D Jablonowski, Andreas Linden, Stephan Köppchen, Björn Thiele, Diana Hofmann, Werner Mittelstaedt, Thomas Pütz, Peter Burauel. Long-term persistence of various 14C-labeled pesticides in soils. Environmental pollution (Barking, Essex : 1987). 2012 Sep; 168(?):29-36. doi: 10.1016/j.envpol.2012.04.022. [PMID: 22591787]
  • Philipp Dalkmann, Ulrich Menke, Dieter Schäfer, Jürgen Keppler, Stefan Pätzold. Aging of methabenzthiazuron, imidacloprid, and N,N-dimethylsulfamide in silty soils and effects on sorption and dissipation. Environmental toxicology and chemistry. 2012 Mar; 31(3):556-65. doi: 10.1002/etc.1734. [PMID: 22213400]
  • Amornrat Phongdara, Alisa Nakkaew, Sureeporn Nualkaew. Isolation of the detoxification enzyme EgP450 from an oil palm EST library. Pharmaceutical biology. 2012 Jan; 50(1):120-7. doi: 10.3109/13880209.2011.631019. [PMID: 22196587]
  • Yishan Chen, Xulin Pan, He Yan, Ninghua Tan. Multiple hydrogen-bonding interactions between macrocyclic triurea and F-, Cl-, Br-, I- and NO3(-): a theoretical investigation. Physical chemistry chemical physics : PCCP. 2011 Apr; 13(16):7384-95. doi: 10.1039/c0cp02749a. [PMID: 21423984]
  • Michel R Corboz, Maria A Rivelli, Kevin D McCormick, Yuntao Wan, Himanshu Shah, Shelby Umland, Gisela Lieber, Yanlin Jia, Robbie L McLeod, Cynthia Morgan, Geoffrey B Varty, Jie Wu, Kung-I Feng, Christopher W Boyce, Robert G Aslanian, Jai Palamanda, Amin A Nomeir, Walter Korfmacher, John C Hunter, John C Anthes, John A Hey. Pharmacological characterization of a novel α2C-adrenoceptor agonist N-[3,4-dihydro-4-(1H-imidazol-4-ylmethyl)-2H-1, 4-benzoxazin-6-yl]-N-ethyl-N'-methylurea (compound A). The Journal of pharmacology and experimental therapeutics. 2011 Apr; 337(1):256-66. doi: 10.1124/jpet.110.175794. [PMID: 21233198]
  • James Keith Ellis, Toby James Athersuch, Rachel Cavill, Robert Radford, Craig Slattery, Paul Jennings, Tara McMorrow, Michael P Ryan, Timothy Mark David Ebbels, Hector Charles Keun. Metabolic response to low-level toxicant exposure in a novel renal tubule epithelial cell system. Molecular bioSystems. 2011 Jan; 7(1):247-57. doi: 10.1039/c0mb00146e. [PMID: 21103459]
  • Abdul Rashid Bhat, Muhammed Afzal Wani, A R Kirmani. Brain cancer and pesticide relationship in orchard farmers of Kashmir. Indian journal of occupational and environmental medicine. 2010 Sep; 14(3):78-86. doi: 10.4103/0019-5278.75694. [PMID: 21461159]
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  • Christina Ramel, Micha Tobler, Martin Meyer, Laurent Bigler, Marc-Olivier Ebert, Barbara Schellenberg, Robert Dudler. Biosynthesis of the proteasome inhibitor syringolin A: the ureido group joining two amino acids originates from bicarbonate. BMC biochemistry. 2009 Oct; 10(?):26. doi: 10.1186/1471-2091-10-26. [PMID: 19863801]
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  • Frank F Millenaar, Martijn Van Zanten, Marjolein C H Cox, Ronald Pierik, Laurentius A C J Voesenek, Anton J M Peeters. Differential petiole growth in Arabidopsis thaliana: photocontrol and hormonal regulation. The New phytologist. 2009; 184(1):141-152. doi: 10.1111/j.1469-8137.2009.02921.x. [PMID: 19558423]
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  • Nobukazu Kakui, Koichi Kitamura. Direct evidence that stimulation of neuropeptide Y Y5 receptor activates hypothalamo-pituitary-adrenal axis in conscious rats via both corticotropin-releasing factor- and arginine vasopressin-dependent pathway. Endocrinology. 2007 Jun; 148(6):2854-62. doi: 10.1210/en.2007-0189. [PMID: 17363455]
  • Gavin S Stewart, Sarah L King, Elizabeth A Potter, Craig P Smith. Acute regulation of mUT-A3 urea transporter expressed in a MDCK cell line. American journal of physiology. Renal physiology. 2007 Apr; 292(4):F1157-63. doi: 10.1152/ajprenal.00183.2006. [PMID: 17148784]
  • Nuzhat Gull, Priyankar Sen, Kabir-Ud-Din, Rizwan Hasan Khan. Effect of physiological concentration of urea on the conformation of human serum albumin. Journal of biochemistry. 2007 Feb; 141(2):261-8. doi: 10.1093/jb/mvm027. [PMID: 17172263]
  • Wells A Messersmith, Michelle A Rudek, Sharyn D Baker, Ming Zhao, Connie Collins, A Dimitrios Colevas, Ross C Donehower, Michael A Carducci, Antonio C Wolff. Phase I study of continuous weekly dosing of dimethylamino benzoylphenylurea (BPU) in patients with solid tumours. European journal of cancer (Oxford, England : 1990). 2007 Jan; 43(1):78-86. doi: 10.1016/j.ejca.2006.09.006. [PMID: 17084620]
  • I Cydzik, J R Albert-García, J Martínez Calatayud. Photo-induced fluorescence of fluometuron in a continuous-flow multicommutation assembly. Journal of fluorescence. 2007 Jan; 17(1):29-36. doi: 10.1007/s10895-006-0147-z. [PMID: 17165123]
  • Malathi Srinivasan, Vasanthi Nachiappan, Ram Rajasekharan. Potential application of urea-derived herbicides as cytokinins in plant tissue culture. Journal of biosciences. 2006 Dec; 31(5):599-605. doi: 10.1007/bf02708412. [PMID: 17301498]
  • Lina Panayiota Aristoteli, Mark D P Willcox. The adhesion of Pseudomonas aeruginosa to high molecular weight human tear film species corresponds to glycoproteins reactive with Sambucus nigra lectin. Experimental eye research. 2006 Nov; 83(5):1146-53. doi: 10.1016/j.exer.2006.06.002. [PMID: 16844114]
  • Nuzhat Gull, Sanjeev Kumar, Basir Ahmad, Rizwan Hassan Khan, Kabir-ud-Din. Influence of urea additives on micellar morphology/protein conformation. Colloids and surfaces. B, Biointerfaces. 2006 Aug; 51(1):10-5. doi: 10.1016/j.colsurfb.2006.04.020. [PMID: 16806852]
  • Nobukazu Kakui, Jiro Tanaka, Yuji Tabata, Kenji Asai, Naomi Masuda, Takako Miyara, Yuko Nakatani, Fukuichi Ohsawa, Naoyuki Nishikawa, Masaharu Sugai, Makoto Suzuki, Kozo Aoki, Hiroshi Kitaguchi. Pharmacological characterization and feeding-suppressive property of FMS586 [3-(5,6,7,8-tetrahydro-9-isopropyl-carbazol-3-yl)-1-methyl-1-(2-pyridin-4-yl-ethyl)-urea hydrochloride], a novel, selective, and orally active antagonist for neuropeptide Y Y5 receptor. The Journal of pharmacology and experimental therapeutics. 2006 May; 317(2):562-70. doi: 10.1124/jpet.105.099705. [PMID: 16436501]
  • David S Jones, Jasmina Djokic, Sean P Gorman. Characterization and optimization of experimental variables within a reproducible bladder encrustation model and in vitro evaluation of the efficacy of urease inhibitors for the prevention of medical device-related encrustation. Journal of biomedical materials research. Part B, Applied biomaterials. 2006 Jan; 76(1):1-7. doi: 10.1002/jbm.b.30230. [PMID: 16206254]
  • Michelle A Rudek, Ming Zhao, Ping He, Yelena Zabelina, Runyan Jin, Wells A Messersmith, Antonio C Wolff, Sharyn D Baker. Validation and implementation of a liquid chromatography/tandem mass spectrometry assay to quantitate dimethyl benzoylphenylurea (BPU) and its five metabolites in human plasma and urine for clinical pharmacology studies. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2005 Dec; 828(1-2):41-54. doi: 10.1016/j.jchromb.2005.09.027. [PMID: 16253576]
  • Michelle A Rudek, Ming Zhao, Nicola F Smith, Robert W Robey, Ping He, Gurulingappa Hallur, Saeed Khan, Manuel Hidalgo, Antonio Jimeno, A Dimitrios Colevas, Wells A Messersmith, Antonio C Wolff, Sharyn D Baker. In vitro and in vivo clinical pharmacology of dimethyl benzoylphenylurea, a novel oral tubulin-interactive agent. Clinical cancer research : an official journal of the American Association for Cancer Research. 2005 Dec; 11(23):8503-11. doi: 10.1158/1078-0432.ccr-05-1037. [PMID: 16322314]
  • Lemma W Mengistu, Michael J Christoffers, Rodney G Lym. A psbA mutation in Kochia scoparia (L) Schrad from railroad rights-of-way with resistance to diuron, tebuthiuron and metribuzin. Pest management science. 2005 Nov; 61(11):1035-42. doi: 10.1002/ps.1079. [PMID: 15952238]
  • Michelle A Rudek, Yelena Zabelina, Ming Zhao, Antonio C Wolff, Sharyn D Baker. A method for determination of dimethyl benzoylphenyl urea (BPU) in human plasma by using LC/UV. Biomedical chromatography : BMC. 2004 Jun; 18(5):282-7. doi: 10.1002/bmc.314. [PMID: 15236435]
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  • Stefan Pfuhler, Hans Uwe Wolf. Effects of the formaldehyde releasing preservatives dimethylol urea and diazolidinyl urea in several short-term genotoxicity tests. Mutation research. 2002 Feb; 514(1-2):133-46. doi: 10.1016/s1383-5718(01)00335-7. [PMID: 11815252]
  • Ying Feng, Zhi Wu Yu, Peter J Quinn. Effect of urea, dimethylurea, and tetramethylurea on the phase behavior of dioleoylphosphatidylethanolamine. Chemistry and physics of lipids. 2002 Feb; 114(2):149-57. doi: 10.1016/s0009-3084(01)00198-0. [PMID: 11934396]
  • Julian O D Coleman, Carla Frova, Peter Schroder, Michel Tissut. Exploiting plant metabolism for the phytoremediation of persistent herbicides. Environmental science and pollution research international. 2002; 9(1):18-28. doi: 10.1007/bf02987314. [PMID: 11885415]
  • F I Mostafa, C S Helling. Isoproturon degradation as affected by the growth of two algal species at different concentrations and pH values. Journal of environmental science and health. Part. B, Pesticides, food contaminants, and agricultural wastes. 2001 Nov; 36(6):709-27. doi: 10.1081/pfc-100107406. [PMID: 11757732]
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