Angiotensin (1-9) (BioDeep_00000010943)
代谢物信息卡片
化学式: C56H78N16O13 (1182.5934)
中文名称: 血管紧张素I
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC4=CN=CN4)C(=O)O)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N
InChI: InChI=1S/C56H78N16O13/c1-5-31(4)46(71-50(79)40(22-33-15-17-36(73)18-16-33)67-52(81)45(30(2)3)70-48(77)38(13-9-19-62-56(58)59)65-47(76)37(57)25-44(74)75)53(82)68-41(23-34-26-60-28-63-34)54(83)72-20-10-14-43(72)51(80)66-39(21-32-11-7-6-8-12-32)49(78)69-42(55(84)85)24-35-27-61-29-64-35/h6-8,11-12,15-18,26-31,37-43,45-46,73H,5,9-10,13-14,19-25,57H2,1-4H3,(H,60,63)(H,61,64)(H,65,76)(H,66,80)(H,67,81)(H,68,82)(H,69,78)(H,70,77)(H,71,79)(H,74,75)(H,84,85)(H4,58,59,62)/t31-,37-,38-,39-,40-,41-,42-,43-,45-,46-/m0/s1
描述信息
A nine amino acid peptide which is formed when angiotensin converting enzyme 2 (ACE2) hydrolyzes the carboxy terminal leucine from angiotensin I. It is a anti-cardiac hypertrophy agent.
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
COVID info from WikiPathways
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
数据库引用编号
9 个数据库交叉引用编号
- ChEBI: CHEBI:80128
- KEGG: C15851
- PubChem: 71745056
- PubChem: 74764048
- CAS: 34273-12-6
- PMhub: MS000024848
- MetaboLights: MTBLC80128
- PubChem: 47205171
- NIKKAJI: J401.528B
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
8 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(6)
- Renin-angiotensin system:
Angiotensin 1 ⟶ Angiotensin II - ACE inhibitor pathway:
Deoxycorticosterone ⟶ Aldosterone - ACE inhibitor pathway:
Deoxycorticosterone ⟶ Aldosterone - Deregulation of renin-angiotensin system by SARS-CoV infection:
Angiotensin II ⟶ Angiotensin-(1-7) - RAS and bradykinin pathways in COVID-19:
L-arginine ⟶ nitric oxide - Mitochondrial immune response to SARS-CoV-2:
angiotensin I ⟶ angiotensin II
Plant Reactome(0)
INOH(0)
PlantCyc(0)
PathBank(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mariele Montanari, Barbara Canonico, Evelyn Nordi, Daniela Vandini, Simone Barocci, Serena Benedetti, Eugenio Carlotti, Loris Zamai. Which ones, when and why should renin-angiotensin system inhibitors work against COVID-19?.
Advances in biological regulation.
2021 08; 81(?):100820. doi:
10.1016/j.jbior.2021.100820. [PMID: 34419773] - Oliver Domenig, Arndt Manzel, Nadja Grobe, Eva Königshausen, Christopher C Kaltenecker, Johannes J Kovarik, Johannes Stegbauer, Susan B Gurley, Dunja van Oyen, Marlies Antlanger, Michael Bader, Daisy Motta-Santos, Robson A Santos, Khalid M Elased, Marcus D Säemann, Ralf A Linker, Marko Poglitsch. Neprilysin is a Mediator of Alternative Renin-Angiotensin-System Activation in the Murine and Human Kidney.
Scientific reports.
2016 09; 6(?):33678. doi:
10.1038/srep33678. [PMID: 27649628] - Ana Cristina Simões E Silva, Mauro Martins Teixeira. ACE inhibition, ACE2 and angiotensin-(1-7) axis in kidney and cardiac inflammation and fibrosis.
Pharmacological research.
2016 05; 107(?):154-162. doi:
10.1016/j.phrs.2016.03.018. [PMID: 26995300] - Francisco Westermeier, Mario Bustamante, Mario Pavez, Lorena García, Mario Chiong, María Paz Ocaranza, Sergio Lavandero. Novel players in cardioprotection: Insulin like growth factor-1, angiotensin-(1-7) and angiotensin-(1-9).
Pharmacological research.
2015 Nov; 101(?):41-55. doi:
10.1016/j.phrs.2015.06.018. [PMID: 26238180] - Evelyn Mendoza-Torres, Alejandra Oyarzún, David Mondaca-Ruff, Andrés Azocar, Pablo F Castro, Jorge E Jalil, Mario Chiong, Sergio Lavandero, María Paz Ocaranza. ACE2 and vasoactive peptides: novel players in cardiovascular/renal remodeling and hypertension.
Therapeutic advances in cardiovascular disease.
2015 Aug; 9(4):217-37. doi:
10.1177/1753944715597623. [PMID: 26275770] - Maria Paz Ocaranza, Luis Michea, Mario Chiong, Carlos F Lagos, Sergio Lavandero, Jorge E Jalil. Recent insights and therapeutic perspectives of angiotensin-(1-9) in the cardiovascular system.
Clinical science (London, England : 1979).
2014 Nov; 127(9):549-57. doi:
10.1042/cs20130449. [PMID: 25029123] - Seung Ah Cha, Byung Mun Park, Shan Gao, Suhn Hee Kim. Stimulation of ANP by angiotensin-(1-9) via the angiotensin type 2 receptor.
Life sciences.
2013 Dec; 93(24):934-40. doi:
10.1016/j.lfs.2013.10.020. [PMID: 24177599] - Minghao Ye, Jan Wysocki, Francisco R Gonzalez-Pacheco, Mahmoud Salem, Karla Evora, Laura Garcia-Halpin, Marko Poglitsch, Manfred Schuster, Daniel Batlle. Murine recombinant angiotensin-converting enzyme 2: effect on angiotensin II-dependent hypertension and distinctive angiotensin-converting enzyme 2 inhibitor characteristics on rodent and human angiotensin-converting enzyme 2.
Hypertension (Dallas, Tex. : 1979).
2012 Sep; 60(3):730-40. doi:
10.1161/hypertensionaha.112.198622. [PMID: 22777933] - K Kramkowski, A Mogielnicki, A Leszczynska, W Buczko. Angiotensin-(1-9), the product of angiotensin I conversion in platelets, enhances arterial thrombosis in rats.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2010 Jun; 61(3):317-24. doi:
. [PMID: 20610862] - Maria Paz Ocaranza, Sergio Lavandero, Jorge E Jalil, Jaqueline Moya, Melissa Pinto, Ulises Novoa, Felipe Apablaza, Leticia Gonzalez, Carol Hernandez, Manuel Varas, Rene Lopez, Ivan Godoy, Hugo Verdejo, Mario Chiong. Angiotensin-(1-9) regulates cardiac hypertrophy in vivo and in vitro.
Journal of hypertension.
2010 May; 28(5):1054-64. doi:
10.1097/hjh.0b013e328335d291. [PMID: 20411619] - Hossam A Shaltout, Brian M Westwood, David B Averill, Carlos M Ferrario, Jorge P Figueroa, Debra I Diz, James C Rose, Mark C Chappell. Angiotensin metabolism in renal proximal tubules, urine, and serum of sheep: evidence for ACE2-dependent processing of angiotensin II.
American journal of physiology. Renal physiology.
2007 Jan; 292(1):F82-91. doi:
10.1152/ajprenal.00139.2006. [PMID: 16896185] - María Paz Ocaranza, Ivan Godoy, Jorge E Jalil, Manuel Varas, Patricia Collantes, Melissa Pinto, Maritza Roman, Cristián Ramirez, Miguel Copaja, Guillermo Diaz-Araya, Pablo Castro, Sergio Lavandero. Enalapril attenuates downregulation of Angiotensin-converting enzyme 2 in the late phase of ventricular dysfunction in myocardial infarcted rat.
Hypertension (Dallas, Tex. : 1979).
2006 Oct; 48(4):572-8. doi:
10.1161/01.hyp.0000237862.94083.45. [PMID: 16908757] - Khalid M Elased, Tatiana S Cunha, Susan B Gurley, Thomas M Coffman, Mariana Morris. New mass spectrometric assay for angiotensin-converting enzyme 2 activity.
Hypertension (Dallas, Tex. : 1979).
2006 May; 47(5):1010-7. doi:
10.1161/01.hyp.0000215588.38536.30. [PMID: 16585421] - Christos Tikellis, Colin I Johnston, Josephine M Forbes, Wendy C Burns, Louise M Burrell, John Risvanis, Mark E Cooper. Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathy.
Hypertension (Dallas, Tex. : 1979).
2003 Mar; 41(3):392-7. doi:
10.1161/01.hyp.0000060689.38912.cb. [PMID: 12623933] - . .
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