Pregnenolone carbonitrile (BioDeep_00000010807)

   


代谢物信息卡片


Pregnenolone carbonitrile; 3beta-Hydroxy-20-oxo-5-pregnene-16alpha-carbonitrile; Pregnenolone-16alpha-carbonitrile; PCN

化学式: C22H31NO2 (341.2354666)
中文名称: 孕烯醇酮-16α-腈
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC(=O)C1C(C#N)CC2C3CC=C4CC(O)CCC4(C)C3CCC21C
InChI: InChI=1S/C22H31NO2/c1-13(24)20-14(12-23)10-19-17-5-4-15-11-16(25)6-8-21(15,2)18(17)7-9-22(19,20)3/h4,14,16-20,25H,5-11H2,1-3H3/t14-,16-,17+,18-,19-,20-,21-,22-/m0/s1

描述信息

同义名列表

7 个代谢物同义名

3beta-Hydroxy-20-oxo-5-pregnene-16alpha-carbonitrile; Pregnenolone-16alpha-carbonitrile; Pregnenolone 16α-carbonitrile; Pregnenolone carbonitrile; PCN; Pregnenolone carbonitrile; 3beta-Hydroxy-20-oxo-5-pregnene-16alpha-carbonitrile; Pregnenolone-16alpha-carbonitrile; PCN; Pregnenolone carbonitrile



数据库引用编号

11 个数据库交叉引用编号

分类词条

相关代谢途径

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代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

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0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Yue Li, Qian Wang, Jingyi Jin, Bo Tan, Jie Ren, Guochao Song, Bin Zou, Fengyi Weng, Dongming Yan, Furong Qiu. 15,16-dihydrotanshinone I in Danshen ethanol extract aggravated cholestasis by inhibiting Cyp3a11 mediated bile acids hydroxylation. Toxicology letters. 2023 Feb; 377(?):62-70. doi: 10.1016/j.toxlet.2023.02.005. [PMID: 36804361]
  • Siqi Chen, Tingting Li, Donglian Deng, Yibing Ji, Ruijun Li. Bifunctional Fe@PCN-222 nanozyme-based cascade reaction system: Application in ratiometric fluorescence and colorimetric dual-mode sensing of glucose. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy. 2022 Oct; 279(?):121427. doi: 10.1016/j.saa.2022.121427. [PMID: 35640471]
  • Chi Xu, Man He, Beibei Chen, Bin Hu. Magnetic porous coordination networks for preconcentration of various metal ions from environmental water followed by inductively coupled plasma mass spectrometry detection. Talanta. 2022 Aug; 245(?):123470. doi: 10.1016/j.talanta.2022.123470. [PMID: 35427948]
  • Daqian Wang, Zhihao Zhang, Shuchuan Xu, Ying Guo, Shifei Kang, Xijiang Chang. H2+CO2 Synergistic Plasma Positioning Carboxyl Defects in g-C3N4 with Engineered Electronic Structure and Active Sites for Efficient Photocatalytic H2 Evolution. International journal of molecular sciences. 2022 Jul; 23(13):. doi: 10.3390/ijms23137381. [PMID: 35806384]
  • Wei Zhang, Jin Li, Na Zhao, Ping Li, Wen Zhang, Hui Wang, Bo Tang. Ratiometric fluorescence biosensor for imaging of protein phosphorylation levels in atherosclerosis mice. Analytica chimica acta. 2022 May; 1208(?):339825. doi: 10.1016/j.aca.2022.339825. [PMID: 35525587]
  • NULL. Percutaneous nephrostomy for nondilated renal collecting system with ultrasound and fluoroscopic guidance: The results of a 10-year experience. Diagnostic and interventional radiology (Ankara, Turkey). 2022 May; 28(3):244-248. doi: 10.5152/dir.2022.20728. [PMID: 35748207]
  • Heba Nabil, Outi Kummu, Petri Lehenkari, Jaana Rysä, Juha Risteli, Jukka Hakkola, Janne Hukkanen. Rifampicin induces the bone form of alkaline phosphatase in humans. Basic & clinical pharmacology & toxicology. 2022 Jan; 130 Suppl 1(?):81-94. doi: 10.1111/bcpt.13586. [PMID: 33851518]
  • Mengfan Xia, Tongtong Liu, Yaodong Zhang. Peroxidase-mimicking Activity of PCN-222(Fe) for Colorimetric Sensing of Acetylcholinesterase Activity and Inhibition. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2021 Jul; 37(7):1023-1027. doi: 10.2116/analsci.20n023. [PMID: 33071263]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Maya Okamura, Ryota Shizu, Taiki Abe, Susumu Kodama, Takuomi Hosaka, Takamitsu Sasaki, Kouichi Yoshinari. PXR Functionally Interacts with NF-κB and AP-1 to Downregulate the Inflammation-Induced Expression of Chemokine CXCL2 in Mice. Cells. 2020 10; 9(10):. doi: 10.3390/cells9102296. [PMID: 33076328]
  • Nguyen Duy Dat, Yong Ji Huang, Moo Been Chang. Characterization of PCN emission and removal from secondary copper metallurgical processes. Environmental pollution (Barking, Essex : 1987). 2020 Mar; 258(?):113759. doi: 10.1016/j.envpol.2019.113759. [PMID: 31874436]
  • Genki Minegishi, Yasuhiro Kazuki, Yuki Yamasaki, Fuka Okuya, Hidetaka Akita, Mitsuo Oshimura, Kaoru Kobayashi. Comparison of the hepatic metabolism of triazolam in wild-type andCyp3a-knockout mice for understanding CYP3A-mediated metabolism inCYP3A-humanised mice in vivo. Xenobiotica; the fate of foreign compounds in biological systems. 2019 Nov; 49(11):1303-1310. doi: 10.1080/00498254.2018.1560516. [PMID: 30561249]
  • Fatemeh Hassani-Nezhad-Gashti, Jaana Rysä, Outi Kummu, Juha Näpänkangas, Marcin Buler, Mikko Karpale, Janne Hukkanen, Jukka Hakkola. Activation of nuclear receptor PXR impairs glucose tolerance and dysregulates GLUT2 expression and subcellular localization in liver. Biochemical pharmacology. 2018 02; 148(?):253-264. doi: 10.1016/j.bcp.2018.01.001. [PMID: 29309761]
  • Mengyao Gui, Qian Chen, Jinren Ni. Effect of sulfamethoxazole on aerobic denitrification by strain Pseudomonas stutzeri PCN-1. Bioresource technology. 2017 Jul; 235(?):325-331. doi: 10.1016/j.biortech.2017.03.131. [PMID: 28376383]
  • Susumu Kodama, Takuto Shimura, Hideaki Kuribayashi, Taiki Abe, Kouichi Yoshinari. Pregnenolone 16α-carbonitrile ameliorates concanavalin A-induced liver injury in mice independent of the nuclear receptor PXR activation. Toxicology letters. 2017 Apr; 271(?):58-65. doi: 10.1016/j.toxlet.2017.02.018. [PMID: 28237809]
  • Cindy Yanfei Li, Sunny Lihua Cheng, Theo K Bammler, Julia Yue Cui. Editor's Highlight: Neonatal Activation of the Xenobiotic-Sensors PXR and CAR Results in Acute and Persistent Down-regulation of PPARα-Signaling in Mouse Liver. Toxicological sciences : an official journal of the Society of Toxicology. 2016 10; 153(2):282-302. doi: 10.1093/toxsci/kfw127. [PMID: 27413110]
  • Rika Hirashima, Hirofumi Michimae, Hiroaki Takemoto, Aya Sasaki, Yoshinori Kobayashi, Tomoo Itoh, Robert H Tukey, Ryoichi Fujiwara. Induction of the UDP-Glucuronosyltransferase 1A1 during the Perinatal Period Can Cause Neurodevelopmental Toxicity. Molecular pharmacology. 2016 09; 90(3):265-74. doi: 10.1124/mol.116.104174. [PMID: 27413119]
  • Ryota Shizu, Taiki Abe, Satoshi Benoki, Miki Takahashi, Susumu Kodama, Masaaki Miayata, Atsushi Matsuzawa, Kouichi Yoshinari. PXR stimulates growth factor-mediated hepatocyte proliferation by cross-talk with the FOXO transcription factor. The Biochemical journal. 2016 Feb; 473(3):257-66. doi: 10.1042/bj20150734. [PMID: 26574435]
  • Chieri Fujino, Yuki Tamura, Satoko Tange, Hiroyuki Nakajima, Seigo Sanoh, Yoko Watanabe, Naoto Uramaru, Hiroyuki Kojima, Kouichi Yoshinari, Shigeru Ohta, Shigeyuki Kitamura. Metabolism of methiocarb and carbaryl by rat and human livers and plasma, and effect on their PXR, CAR and PPARα activities. The Journal of toxicological sciences. 2016; 41(5):677-91. doi: 10.2131/jts.41.677. [PMID: 27665777]
  • Keiyu Oshida, Naresh Vasani, Russell S Thomas, Dawn Applegate, Mitch Rosen, Barbara Abbott, Christopher Lau, Grace Guo, Lauren M Aleksunes, Curtis Klaassen, J Christopher Corton. Identification of modulators of the nuclear receptor peroxisome proliferator-activated receptor α (PPARα) in a mouse liver gene expression compendium. PloS one. 2015; 10(2):e0112655. doi: 10.1371/journal.pone.0112655. [PMID: 25689681]
  • Akira Kubota, Afonso C D Bainy, Bruce R Woodin, Jared V Goldstone, John J Stegeman. The cytochrome P450 2AA gene cluster in zebrafish (Danio rerio): expression of CYP2AA1 and CYP2AA2 and response to phenobarbital-type inducers. Toxicology and applied pharmacology. 2013 Oct; 272(1):172-9. doi: 10.1016/j.taap.2013.05.017. [PMID: 23726801]
  • J Rysä, M Buler, M J Savolainen, H Ruskoaho, J Hakkola, J Hukkanen. Pregnane X receptor agonists impair postprandial glucose tolerance. Clinical pharmacology and therapeutics. 2013 Jun; 93(6):556-63. doi: 10.1038/clpt.2013.48. [PMID: 23588309]
  • Caroline H Johnson, Jessica A Bonzo, Jie Cheng, Kristopher W Krausz, Dong Wook Kang, Hans Luecke, Jeffrey R Idle, Frank J Gonzalez. Cytochrome P450 regulation by α-tocopherol in Pxr-null and PXR-humanized mice. Drug metabolism and disposition: the biological fate of chemicals. 2013 Feb; 41(2):406-13. doi: 10.1124/dmd.112.048009. [PMID: 23160821]
  • Yu-Guang Wang, Jian-Ming Zhou, Zeng-Chun Ma, Hua Li, Qian-De Liang, Hong-Ling Tan, Cheng-Rong Xiao, Bo-Li Zhang, Yue Gao. Pregnane X receptor mediated-transcription regulation of CYP3A by glycyrrhizin: a possible mechanism for its hepatoprotective property against lithocholic acid-induced injury. Chemico-biological interactions. 2012 Oct; 200(1):11-20. doi: 10.1016/j.cbi.2012.08.023. [PMID: 22982774]
  • Katie B Paul, Joan M Hedge, Ruby Bansal, R Thomas Zoeller, Robert Peter, Michael J DeVito, Kevin M Crofton. Developmental triclosan exposure decreases maternal, fetal, and early neonatal thyroxine: a dynamic and kinetic evaluation of a putative mode-of-action. Toxicology. 2012 Oct; 300(1-2):31-45. doi: 10.1016/j.tox.2012.05.023. [PMID: 22659317]
  • Hiroki Tojima, Satoru Kakizaki, Yuichi Yamazaki, Daichi Takizawa, Norio Horiguchi, Ken Sato, Masatomo Mori. Ligand dependent hepatic gene expression profiles of nuclear receptors CAR and PXR. Toxicology letters. 2012 Aug; 212(3):288-97. doi: 10.1016/j.toxlet.2012.06.001. [PMID: 22698814]
  • Yi Yang, Rita Ciurlionis, Kenneth Kowalkowski, Kennan C Marsh, William M Bracken, Eric A G Blomme. N-vinylpyrrolidone dimer, a novel formulation excipient, causes hepatic and thyroid hypertrophy through the induction of hepatic microsomal enzymes in rats. Toxicology letters. 2012 Jan; 208(1):82-91. doi: 10.1016/j.toxlet.2011.10.012. [PMID: 22037397]
  • Yongjie Ma, Dexi Liu. Activation of pregnane X receptor by pregnenolone 16 α-carbonitrile prevents high-fat diet-induced obesity in AKR/J mice. PloS one. 2012; 7(6):e38734. doi: 10.1371/journal.pone.0038734. [PMID: 22723881]
  • Katsuhide Igarashi, Satoshi Kitajima, Ken-ichi Aisaki, Kentaro Tanemura, Yuhji Taquahashi, Noriko Moriyama, Eriko Ikeno, Nae Matsuda, Yumiko Saga, Bruce Blumberg, Jun Kanno. Development of humanized steroid and xenobiotic receptor mouse by homologous knock-in of the human steroid and xenobiotic receptor ligand binding domain sequence. The Journal of toxicological sciences. 2012; 37(2):373-80. doi: 10.2131/jts.37.373. [PMID: 22467028]
  • Lucie Krausova, Lucie Stejskalova, Hongwei Wang, Radim Vrzal, Zdenek Dvorak, Sridhar Mani, Petr Pavek. Metformin suppresses pregnane X receptor (PXR)-regulated transactivation of CYP3A4 gene. Biochemical pharmacology. 2011 Dec; 82(11):1771-80. doi: 10.1016/j.bcp.2011.08.023. [PMID: 21920351]
  • Akira Honda, Teruo Miyazaki, Tadashi Ikegami, Junichi Iwamoto, Tomomi Maeda, Takeshi Hirayama, Yoshifumi Saito, Tamio Teramoto, Yasushi Matsuzaki. Cholesterol 25-hydroxylation activity of CYP3A. Journal of lipid research. 2011 Aug; 52(8):1509-16. doi: 10.1194/jlr.m014084. [PMID: 21576599]
  • Jinhan He, Shigeru Nishida, Meishu Xu, Makoto Makishima, Wen Xie. PXR prevents cholesterol gallstone disease by regulating biosynthesis and transport of bile salts. Gastroenterology. 2011 Jun; 140(7):2095-106. doi: 10.1053/j.gastro.2011.02.055. [PMID: 21354151]
  • Jian-Ming Liu, Yu-Qing Xiong. [Effect of pravastatin on transportation of scutellarin in mouse liver and its mechanism]. Yao xue xue bao = Acta pharmaceutica Sinica. 2011 Mar; 46(3):269-73. doi: . [PMID: 21626779]
  • Hiroyuki Kojima, Fumihiro Sata, Shinji Takeuchi, Tatsuya Sueyoshi, Tadanori Nagai. Comparative study of human and mouse pregnane X receptor agonistic activity in 200 pesticides using in vitro reporter gene assays. Toxicology. 2011 Feb; 280(3):77-87. doi: 10.1016/j.tox.2010.11.008. [PMID: 21115097]
  • Ian Bailey, G Gordon Gibson, Kathryn Plant, Mark Graham, Nick Plant. A PXR-mediated negative feedback loop attenuates the expression of CYP3A in response to the PXR agonist pregnenalone-16α-carbonitrile. PloS one. 2011 Feb; 6(2):e16703. doi: 10.1371/journal.pone.0016703. [PMID: 21311750]
  • Aik Jiang Lau, Guixiang Yang, Ganesh Rajaraman, Christie C Baucom, Thomas K H Chang. Human pregnane X receptor agonism by Ginkgo biloba extract: assessment of the role of individual ginkgolides. The Journal of pharmacology and experimental therapeutics. 2010 Dec; 335(3):771-80. doi: 10.1124/jpet.110.172338. [PMID: 20739453]
  • Terrilyn A Richardson, Curtis D Klaassen. Disruption of thyroid hormone homeostasis in Ugt1a-deficient Gunn rats by microsomal enzyme inducers is not due to enhanced thyroxine glucuronidation. Toxicology and applied pharmacology. 2010 Oct; 248(1):38-44. doi: 10.1016/j.taap.2010.07.010. [PMID: 20655938]
  • Terrilyn A Richardson, Curtis D Klaassen. Role of UDP-glucuronosyltransferase (UGT) 2B2 in metabolism of triiodothyronine: effect of microsomal enzyme inducers in Sprague Dawley and UGT2B2-deficient Fischer 344 rats. Toxicological sciences : an official journal of the Society of Toxicology. 2010 Aug; 116(2):413-21. doi: 10.1093/toxsci/kfq125. [PMID: 20421340]
  • Yoshihiro Konno, Hiroki Kamino, Rick Moore, Fred Lih, Kenneth B Tomer, Darryl C Zeldin, Joyce A Goldstein, Masahiko Negishi. The nuclear receptors constitutive active/androstane receptor and pregnane x receptor activate the Cyp2c55 gene in mouse liver. Drug metabolism and disposition: the biological fate of chemicals. 2010 Jul; 38(7):1177-82. doi: 10.1124/dmd.110.032334. [PMID: 20371638]
  • Masaaki Miyata, Masahiro Nomoto, Fumiaki Sotodate, Tomohiro Mizuki, Wataru Hori, Miho Nagayasu, Shinya Yokokawa, Shin-ichi Ninomiya, Yasushi Yamazoe. Possible protective role of pregnenolone-16 alpha-carbonitrile in lithocholic acid-induced hepatotoxicity through enhanced hepatic lipogenesis. European journal of pharmacology. 2010 Jun; 636(1-3):145-54. doi: 10.1016/j.ejphar.2010.03.022. [PMID: 20359477]
  • Karine H Hellemans, Jean-Claude Hannaert, Bart Denys, Knut R Steffensen, Cindy Raemdonck, Geert A Martens, Paul P Van Veldhoven, Jan-Ake Gustafsson, Daniel Pipeleers. Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase. PloS one. 2009 Sep; 4(9):e7266. doi: 10.1371/journal.pone.0007266. [PMID: 19787047]
  • Joo-Youn Cho, Dong Wook Kang, Xiaochao Ma, Sung-Hoon Ahn, Kristopher W Krausz, Hans Luecke, Jeffrey R Idle, Frank J Gonzalez. Metabolomics reveals a novel vitamin E metabolite and attenuated vitamin E metabolism upon PXR activation. Journal of lipid research. 2009 May; 50(5):924-37. doi: 10.1194/jlr.m800647-jlr200. [PMID: 19141872]
  • Willeke de Haan, Jitske de Vries-van der Weij, Isabel M Mol, Menno Hoekstra, Johannes A Romijn, J Wouter Jukema, Louis M Havekes, Hans M G Princen, Patrick C N Rensen. PXR agonism decreases plasma HDL levels in ApoE3-Leiden.CETP mice. Biochimica et biophysica acta. 2009 Mar; 1791(3):191-7. doi: 10.1016/j.bbalip.2008.12.008. [PMID: 19150509]
  • Huey-Mei Shaw, Wan-Hsuan Chen. Effects of pregnenolone-16alpha-carbonitrile on vitamin E status and protein levels of antioxidant enzymes in male rats fed a vitamin E-supplemented diet. Redox report : communications in free radical research. 2009; 14(2):61-8. doi: 10.1179/135100009x392494. [PMID: 19389273]
  • Jun Inoue, Shin-Ichi Satoh, Mariko Kita, Mayuko Nakahara, Satoshi Hachimura, Masaaki Miyata, Tomoko Nishimaki-Mogami, Ryuichiro Sato. PPARalpha gene expression is up-regulated by LXR and PXR activators in the small intestine. Biochemical and biophysical research communications. 2008 Jul; 371(4):675-8. doi: 10.1016/j.bbrc.2008.04.100. [PMID: 18448072]
  • Björn Bauer, Anika M S Hartz, Jonathan R Lucking, Xiaodong Yang, Gary M Pollack, David S Miller. Coordinated nuclear receptor regulation of the efflux transporter, Mrp2, and the phase-II metabolizing enzyme, GSTpi, at the blood-brain barrier. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2008 Jun; 28(6):1222-34. doi: 10.1038/jcbfm.2008.16. [PMID: 18349876]
  • Yazen Alnouti, Curtis D Klaassen. Tissue distribution, ontogeny, and regulation of aldehyde dehydrogenase (Aldh) enzymes mRNA by prototypical microsomal enzyme inducers in mice. Toxicological sciences : an official journal of the Society of Toxicology. 2008 Jan; 101(1):51-64. doi: 10.1093/toxsci/kfm280. [PMID: 17998271]
  • Tomoji Maeda, Masanobu Oyabu, Takafumi Yotsumoto, Ryunosuke Higashi, Kiyoshi Nagata, Yasushi Yamazoe, Ikumi Tamai. Effect of pregnane X receptor ligand on pharmacokinetics of substrates of organic cation transporter Oct1 in rats. Drug metabolism and disposition: the biological fate of chemicals. 2007 Sep; 35(9):1580-6. doi: 10.1124/dmd.107.015842. [PMID: 17553914]
  • S Teng, M Piquette-Miller. Hepatoprotective role of PXR activation and MRP3 in cholic acid-induced cholestasis. British journal of pharmacology. 2007 Jun; 151(3):367-76. doi: 10.1038/sj.bjp.0707235. [PMID: 17435798]
  • Kouichi Nakamura, Rick Moore, Masahiko Negishi, Tatsuya Sueyoshi. Nuclear pregnane X receptor cross-talk with FoxA2 to mediate drug-induced regulation of lipid metabolism in fasting mouse liver. The Journal of biological chemistry. 2007 Mar; 282(13):9768-9776. doi: 10.1074/jbc.m610072200. [PMID: 17267396]
  • Yi-Jen Li, Huey-Mei Shaw. Pregnenolone and dexamethasone, modulators of cytochrome P450-3A, not increase but reduce urinary alpha-CEHC excretion in rats. BioFactors (Oxford, England). 2007; 31(1):67-76. doi: 10.1002/biof.5520310107. [PMID: 18806310]
  • Xingguo Cheng, Curtis D Klaassen. Regulation of mRNA expression of xenobiotic transporters by the pregnane x receptor in mouse liver, kidney, and intestine. Drug metabolism and disposition: the biological fate of chemicals. 2006 Nov; 34(11):1863-7. doi: 10.1124/dmd.106.010520. [PMID: 16928788]
  • M Miyata, H Watase, W Hori, M Shimada, K Nagata, F J Gonzalez, Y Yamazoe. Role for enhanced faecal excretion of bile acid in hydroxysteroid sulfotransferase-mediated protection against lithocholic acid-induced liver toxicity. Xenobiotica; the fate of foreign compounds in biological systems. 2006 Jul; 36(7):631-44. doi: 10.1080/00498250600776827. [PMID: 16864508]
  • Ying Mu, Jinnan Zhang, Shimin Zhang, Hong-Hao Zhou, David Toma, Songrong Ren, Leaf Huang, Maria Yaramus, Andrew Baum, Raman Venkataramanan, Wen Xie. Traditional Chinese medicines Wu Wei Zi (Schisandra chinensis Baill) and Gan Cao (Glycyrrhiza uralensis Fisch) activate pregnane X receptor and increase warfarin clearance in rats. The Journal of pharmacology and experimental therapeutics. 2006 Mar; 316(3):1369-77. doi: 10.1124/jpet.105.094342. [PMID: 16267138]
  • Martin Wagner, Emina Halilbasic, Hanns-Ulrich Marschall, Gernot Zollner, Peter Fickert, Cord Langner, Kurt Zatloukal, Helmut Denk, Michael Trauner. CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice. Hepatology (Baltimore, Md.). 2005 Aug; 42(2):420-30. doi: 10.1002/hep.20784. [PMID: 15986414]
  • Ai-Ming Yu, Katsumi Fukamachi, Kristopher W Krausz, Connie Cheung, Frank J Gonzalez. Potential role for human cytochrome P450 3A4 in estradiol homeostasis. Endocrinology. 2005 Jul; 146(7):2911-9. doi: 10.1210/en.2004-1248. [PMID: 15817670]
  • Marita Sporstøl, German Tapia, Lene Malerød, Seyed Ali Mousavi, Trond Berg. Pregnane X receptor-agonists down-regulate hepatic ATP-binding cassette transporter A1 and scavenger receptor class B type I. Biochemical and biophysical research communications. 2005 Jun; 331(4):1533-41. doi: 10.1016/j.bbrc.2005.04.071. [PMID: 15883047]
  • Jean Marc Pascussi, Agnes Robert, Minh Nguyen, Odile Walrant-Debray, Michèle Garabedian, Pascal Martin, Thierry Pineau, Jean Saric, Fréderic Navarro, Patrick Maurel, Marie Josè Vilarem. Possible involvement of pregnane X receptor-enhanced CYP24 expression in drug-induced osteomalacia. The Journal of clinical investigation. 2005 Jan; 115(1):177-86. doi: 10.1172/jci21867. [PMID: 15630458]
  • Grace L Guo, Jeff S Moffit, Christopher J Nicol, Jerrold M Ward, Lauren A Aleksunes, Angela L Slitt, Steven A Kliewer, Jose E Manautou, Frank J Gonzalez. Enhanced acetaminophen toxicity by activation of the pregnane X receptor. Toxicological sciences : an official journal of the Society of Toxicology. 2004 Dec; 82(2):374-80. doi: 10.1093/toxsci/kfh286. [PMID: 15456926]
  • Matthew Z Dieter, Jonathan M Maher, Xingguo Cheng, Curtis D Klaassen. Expression and regulation of the sterol half-transporter genes ABCG5 and ABCG8 in rats. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2004 Dec; 139(4):209-18. doi: 10.1016/j.cca.2004.11.002. [PMID: 15683829]
  • Min Sun Kim, Judy Shigenaga, Art Moser, Carl Grunfeld, Kenneth R Feingold. Suppression of DHEA sulfotransferase (Sult2A1) during the acute-phase response. American journal of physiology. Endocrinology and metabolism. 2004 Oct; 287(4):E731-8. doi: 10.1152/ajpendo.00130.2004. [PMID: 15198932]
  • Nichole R Vansell, Jagan R Muppidi, Sultan M Habeebu, Curtis D Klaassen. Promotion of thyroid tumors in rats by pregnenolone-16alpha-carbonitrile (PCN) and polychlorinated biphenyl (PCB). Toxicological sciences : an official journal of the Society of Toxicology. 2004 Sep; 81(1):50-9. doi: 10.1093/toxsci/kfh197. [PMID: 15201439]
  • Christopher J Matheny, Rabia Y Ali, Xiaodong Yang, Gary M Pollack. Effect of prototypical inducing agents on P-glycoprotein and CYP3A expression in mouse tissues. Drug metabolism and disposition: the biological fate of chemicals. 2004 Sep; 32(9):1008-14. doi: ". [PMID: 15319343]
  • Dan E Brobst, Xunshan Ding, Katrina L Creech, Bryan Goodwin, Brian Kelley, Jeff L Staudinger. Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane X receptor. The Journal of pharmacology and experimental therapeutics. 2004 Aug; 310(2):528-35. doi: 10.1124/jpet.103.064329. [PMID: 15075359]
  • Weisheng Zhang, Anthony F Purchio, Kevin Chen, Jianming Wu, Li Lu, Richard Coffee, Pamela R Contag, David B West. A transgenic mouse model with a luciferase reporter for studying in vivo transcriptional regulation of the human CYP3A4 gene. Drug metabolism and disposition: the biological fate of chemicals. 2003 Aug; 31(8):1054-64. doi: 10.1124/dmd.31.8.1054. [PMID: 12867495]
  • Alan Hood, Marcia L Allen, YaPing Liu, Jie Liu, Curtis D Klaassen. Induction of T(4) UDP-GT activity, serum thyroid stimulating hormone, and thyroid follicular cell proliferation in mice treated with microsomal enzyme inducers. Toxicology and applied pharmacology. 2003 Apr; 188(1):6-13. doi: 10.1016/s0041-008x(02)00071-6. [PMID: 12668117]
  • G Gordon Gibson, Wafaa el-Sankary, Nick J Plant. Receptor-dependent regulation of the CYP3A4 gene. Toxicology. 2002 Dec; 181-182(?):199-202. doi: 10.1016/s0300-483x(02)00281-0. [PMID: 12505310]
  • David R Johnson, Curtis D Klaassen. Role of rat multidrug resistance protein 2 in plasma and biliary disposition of dibromosulfophthalein after microsomal enzyme induction. Toxicology and applied pharmacology. 2002 Apr; 180(1):56-63. doi: 10.1006/taap.2002.9375. [PMID: 11922777]
  • Nichole R Vansell, Curtis D Klaassen. Effect of microsomal enzyme inducers on the biliary excretion of triiodothyronine (T(3)) and its metabolites. Toxicological sciences : an official journal of the Society of Toxicology. 2002 Feb; 65(2):184-91. doi: 10.1093/toxsci/65.2.184. [PMID: 11812922]
  • Nathan J Cherrington, Dylan P Hartley, Ning Li, David R Johnson, Curtis D Klaassen. Organ distribution of multidrug resistance proteins 1, 2, and 3 (Mrp1, 2, and 3) mRNA and hepatic induction of Mrp3 by constitutive androstane receptor activators in rats. The Journal of pharmacology and experimental therapeutics. 2002 Jan; 300(1):97-104. doi: 10.1124/jpet.300.1.97. [PMID: 11752103]
  • N R Vansell, C D Klaassen. Increased biliary excretion of thyroxine by microsomal enzyme inducers. Toxicology and applied pharmacology. 2001 Nov; 176(3):187-94. doi: 10.1006/taap.2001.9278. [PMID: 11714251]
  • L C Rausch-Derra, D P Hartley, P J Meier, C D Klaassen. Differential effects of microsomal enzyme-inducing chemicals on the hepatic expression of rat organic anion transporters, OATP1 and OATP2. Hepatology (Baltimore, Md.). 2001 Jun; 33(6):1469-78. doi: 10.1053/jhep.2001.25088. [PMID: 11391536]
  • B D Jiménez, L C Quattrochi, C B Yockey, P S Guzelian. Identification by differential display of the IF1 inhibitor peptide of ATP synthase/ATPase as a gene inducible in rat liver by pregnenolone 16alpha-carbonitrile. Life sciences. 2000 Sep; 67(15):1825-32. doi: 10.1016/s0024-3205(00)00769-4. [PMID: 11043605]
  • A Hood, C D Klaassen. Differential effects of microsomal enzyme inducers on in vitro thyroxine (T(4)) and triiodothyronine (T(3)) glucuronidation. Toxicological sciences : an official journal of the Society of Toxicology. 2000 May; 55(1):78-84. doi: 10.1093/toxsci/55.1.78. [PMID: 10788562]
  • M Y Law, M H Slawson, D E Moody. Selective involvement of cytochrome P450 2D subfamily in in vivo 4-hydroxylation of amphetamine in rat. Drug metabolism and disposition: the biological fate of chemicals. 2000 Mar; 28(3):348-53. doi: NULL. [PMID: 10681381]
  • A Hood, R Hashmi, C D Klaassen. Effects of microsomal enzyme inducers on thyroid-follicular cell proliferation, hyperplasia, and hypertrophy. Toxicology and applied pharmacology. 1999 Oct; 160(2):163-70. doi: 10.1006/taap.1999.8752. [PMID: 10527915]
  • M Lu, S M Poloyac, P J McNamara, R A Blouin. The effect of pregnenolone 16alpha-carbonitrile on the pharmacokinetics and metabolism of dapsone in rats. The Journal of pharmacy and pharmacology. 1999 Jul; 51(7):803-10. doi: 10.1211/0022357991773177. [PMID: 10467955]
  • K L Kolaja, A M Hood, C D Klaassen. The UDP-glucuronyltransferase inducers, phenobarbital and pregnenolone-16alpha-carbonitrile, enhance thyroid-follicular cell apoptosis: association with TGF-beta1 expression. Toxicology letters. 1999 Jun; 106(2-3):143-50. doi: 10.1016/s0378-4274(99)00023-5. [PMID: 10403658]
  • C Viollon-Abadie, D Lassere, E Debruyne, L Nicod, N Carmichael, L Richert. Phenobarbital, beta-naphthoflavone, clofibrate, and pregnenolone-16alpha-carbonitrile do not affect hepatic thyroid hormone UDP-glucuronosyl transferase activity, and thyroid gland function in mice. Toxicology and applied pharmacology. 1999 Feb; 155(1):1-12. doi: 10.1006/taap.1998.8558. [PMID: 10036213]
  • K L Kolaja, C D Klaassen. Dose-response examination of UDP-glucuronosyltransferase inducers and their ability to increase both TGF-beta expression and thyroid follicular cell apoptosis. Toxicological sciences : an official journal of the Society of Toxicology. 1998 Nov; 46(1):31-7. doi: 10.1006/toxs.1998.2510. [PMID: 9928666]
  • K Debri, A R Boobis, D S Davies, R J Edwards. Distribution and induction of CYP3A1 and CYP3A2 in rat liver and extrahepatic tissues. Biochemical pharmacology. 1995 Dec; 50(12):2047-56. doi: 10.1016/0006-2952(95)02107-8. [PMID: 8849332]
  • T N Thompson, C D Klaassen. The effects of hepatic microsomal enzyme inducers on the pharmacokinetics of ouabain after portal and systemic administration to rats. The Journal of pharmacy and pharmacology. 1995 Dec; 47(12A):1041-7. doi: 10.1111/j.2042-7158.1995.tb03294.x. [PMID: 8932692]
  • J Liu, Y Liu, R A Barter, C D Klaassen. Alteration of thyroid homeostasis by UDP-glucuronosyltransferase inducers in rats: a dose-response study. The Journal of pharmacology and experimental therapeutics. 1995 May; 273(2):977-85. doi: NULL. [PMID: 7752103]
  • P N Kourounakis, E Rekka. Effect of spironolactone on dimethyl mercury toxicity. A possible molecular mechanism. Arzneimittel-Forschung. 1994 Oct; 44(10):1150-3. doi: . [PMID: 7818591]
  • T Cresteil, S Marie, M Sonnier, J Kersual, F J Gonzalez. Evidence for the transient expression of P-450 during the neonatal period in rat. Biochimica et biophysica acta. 1994 Sep; 1208(1):111-7. doi: 10.1016/0167-4838(94)90167-8. [PMID: 8086424]
  • R A Barter, C D Klaassen. Reduction of thyroid hormone levels and alteration of thyroid function by four representative UDP-glucuronosyltransferase inducers in rats. Toxicology and applied pharmacology. 1994 Sep; 128(1):9-17. doi: 10.1006/taap.1994.1174. [PMID: 8079359]
  • R F Omar, A D Rahimtula. Possible role of an iron-oxygen complex in 4(S)-4-hydroxyochratoxin a formation by rat liver microsomes. Biochemical pharmacology. 1993 Dec; 46(11):2073-81. doi: 10.1016/0006-2952(93)90650-l. [PMID: 8267656]
  • M Jurima-Romet, H S Huang. Enalapril hepatotoxicity in the rat. Effects of modulators of cytochrome P450 and glutathione. Biochemical pharmacology. 1992 Nov; 44(9):1803-10. doi: 10.1016/0006-2952(92)90075-t. [PMID: 1449535]
  • C Madhu, T Maziasz, C D Klaassen. Effect of pregnenolone-16 alpha-carbonitrile and dexamethasone on acetaminophen-induced hepatotoxicity in mice. Toxicology and applied pharmacology. 1992 Aug; 115(2):191-8. doi: 10.1016/0041-008x(92)90323-k. [PMID: 1641853]
  • D Li, B Moorthy, S Chen, K Randerath. Effects of cytochrome P450 inducers on I-compounds in rat liver and kidney DNA. Carcinogenesis. 1992 Jul; 13(7):1191-8. doi: 10.1093/carcin/13.7.1191. [PMID: 1638686]
  • B Moorthy, K L van Golen, K Randerath. Sex-specific modulation of hepatic covalent DNA modifications (I-compounds) by the cytochrome P450 inducer, pregnenolone-16 alpha-carbonitrile. Toxicology and applied pharmacology. 1992 Apr; 113(2):218-26. doi: 10.1016/0041-008x(92)90117-b. [PMID: 1561630]
  • P N Kourounakis, E Rekka, L Hadjipetrou-Kourounakis. Restoration of impaired drug metabolism of rats with adjuvant induced disease by two steroids with different influence on drug biotransformation. Die Pharmazie. 1991 Oct; 46(10):727-9. doi: ". [PMID: 1803389]
  • C Madhu, C D Klaassen. Protective effect of pregnenolone-16 alpha-carbonitrile on acetaminophen-induced hepatotoxicity in hamsters. Toxicology and applied pharmacology. 1991 Jun; 109(2):305-13. doi: 10.1016/0041-008x(91)90177-g. [PMID: 2068728]
  • P N Kourounakis, E Rekka. Effect of adaptive steroids on the impairment of hepatic drug metabolic activity caused by hepatotoxic agents. European journal of drug metabolism and pharmacokinetics. 1991; Spec No 3(?):17-23. doi: . [PMID: 1820873]
  • P I Craig, I Mehta, M Murray, D McDonald, A Aström, P H van der Meide, G C Farrell. Interferon down regulates the male-specific cytochrome P450IIIA2 in rat liver. Molecular pharmacology. 1990 Sep; 38(3):313-8. doi: . [PMID: 1698250]
  • Y A Yusof, A M Edwards. Stimulation of DNA synthesis in primary rat hepatocyte cultures by liver tumor promoters: interactions with other growth factors. Carcinogenesis. 1990 May; 11(5):761-70. doi: 10.1093/carcin/11.5.761. [PMID: 1692266]
  • E Sartori, M Delaforge. Specific drug binding to rat liver cytochrome P-450 isozymes induced by pregnenolone-16 alpha-carbonitrile and macrolide antibiotics. Implications for drug interactions. Chemico-biological interactions. 1990; 73(2-3):297-307. doi: 10.1016/0009-2797(90)90010-k. [PMID: 2107034]
  • Z Gregus, C Madhu, C D Klaassen. Effect of microsomal enzyme inducers on biliary and urinary excretion of acetaminophen metabolites in rats. Decreased hepatobiliary and increased hepatovascular transport of acetaminophen-glucuronide after microsomal enzyme induction. Drug metabolism and disposition: the biological fate of chemicals. 1990 Jan; 18(1):10-9. doi: NULL. [PMID: 1970767]
  • E Tani, E Rekka, G Iconomidis, P N Kourounakis. Modification of drug metabolic processes by compounds which intervene with the function of cytochrome P-450 as a mono-oxygenase and as an oxidase. Arzneimittel-Forschung. 1989 Nov; 39(11):1399-402. doi: . [PMID: 2619770]