E-3174 (BioDeep_00000010771)
Secondary id: BioDeep_00000404843
human metabolite Endogenous blood metabolite
代谢物信息卡片
2-butyl-4-chloro-1-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-imidazole-5-carboxylic acid
化学式: C22H21ClN6O2 (436.1414)
中文名称: 氯沙坦
谱图信息:
最多检出来源 Homo sapiens(blood) 51.03%
分子结构信息
SMILES: CCCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)C(=O)O)Cl
InChI: InChI=1S/C22H21ClN6O2/c1-2-3-8-18-24-20(23)19(22(30)31)29(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21-25-27-28-26-21/h4-7,9-12H,2-3,8,13H2,1H3,(H,30,31)(H,25,26,27,28)
描述信息
EXP3174 is a metabolite of losartan (previous name DuP753), which is a non-peptide angiotensin II receptor antagonist. EXP3174, a metabolite of losartan (MK 954, DuP 753) is more potent than losartan in blocking the angiotensin II-induced responses in vascular smooth muscle cells. (PMID: 8385175)
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure[1][2][3][4].
同义名列表
10 个代谢物同义名
2-butyl-4-chloro-1-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)-1H-imidazole-5-carboxylic acid; 2-butyl-5-chloro-3-({4-[2-(2H-1,2,3,4-tetrazol-5-yl)phenyl]phenyl}methyl)imidazole-4-carboxylic acid; 2-N-Butyl-4-chloro-1-((2-(1H-tetrazol-5-yl)biphenyl-4-yl)methylll)imidazole-5-carboxylic acid; Losartan Metabolite (E 3174); Losartan carboxylic acid; Losartan carboxylate; EXP 3174; E-3174; EXP-3174; EXP 3174
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:74125
- KEGG: C15554
- PubChem: 108185
- HMDB: HMDB0060553
- Metlin: METLIN1032
- ChEMBL: CHEMBL907
- Wikipedia: 4th millennium
- CAS: 124750-92-1
- PMhub: MS000024661
- PubChem: 17396546
- NIKKAJI: J356.046E
- medchemexpress: HY-12765
- KNApSAcK: 74125
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Rui Li, Chuanzhou Liang, Sif B Svendsen, Vaidotas Kisielius, Kai Bester. Sartan blood pressure regulators in classical and biofilm wastewater treatment - Concentrations and metabolism.
Water research.
2023 Feb; 229(?):119352. doi:
10.1016/j.watres.2022.119352. [PMID: 36450176] - Eleni Karatza, Vangelis Karalis. Modelling gastric emptying: A pharmacokinetic model simultaneously describing distribution of losartan and its active metabolite EXP-3174.
Basic & clinical pharmacology & toxicology.
2020 Mar; 126(3):193-202. doi:
10.1111/bcpt.13321. [PMID: 31514255] - Xiuli Li, Jingchao Sun, Zitao Guo, Dafang Zhong, Xiaoyan Chen. Carboxylesterase 2 and Intestine Transporters Contribute to the Low Bioavailability of Allisartan, a Prodrug of Exp3174 for Hypertension Treatment in Humans.
Drug metabolism and disposition: the biological fate of chemicals.
2019 08; 47(8):843-853. doi:
10.1124/dmd.118.085092. [PMID: 31076412] - A Gromotowicz-Poplawska, J Nazarko-Sadowska, E Chabielska. Losartan metabolite EXP3174 reduces the weight of formed thrombus in 2K1C hypertensive rats.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2019 Jun; 70(3):. doi:
10.26402/jpp.2019.3.11. [PMID: 31566190] - Qingling Zhao, Jinlan Wei, Hongying Zhang. Effects of quercetin on the pharmacokinetics of losartan and its metabolite EXP3174 in rats.
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2019 May; 49(5):563-568. doi:
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Pharmaceutical biology.
2018 Dec; 56(1):333-336. doi:
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Biological & pharmaceutical bulletin.
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