(6S)-1-[4-(dimethylamino)-3-methylbenzyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid (BioDeep_00001028543)
代谢物信息卡片
(6S)-1-[4-(dimethylamino)-3-methylbenzyl]-5-(diphenylacetyl)-4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid
化学式: C31H32N4O3 (508.24742819999994)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1=C(C=CC(=C1)CN2C=NC3=C2CC(N(C3)C(=O)C(C4=CC=CC=C4)C5=CC=CC=C5)C(=O)O)N(C)C
InChI: InChI=1S/C31H32N4O3/c1-21-16-22(14-15-26(21)33(2)3)18-34-20-32-25-19-35(28(31(37)38)17-27(25)34)30(36)29(23-10-6-4-7-11-23)24-12-8-5-9-13-24/h4-16,20,28-29H,17-19H2,1-3H3,(H,37,38)/t28-/m0/s1
描述信息
D057911 - Angiotensin Receptor Antagonists > D057912 - Angiotensin II Type 2 Receptor Blockers
D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents
同义名列表
数据库引用编号
5 个数据库交叉引用编号
- ChEBI: CHEBI:61014
- PubChem: 5311345
- ChEMBL: CHEMBL321820
- ChEMBL: CHEMBL157946
- CAS: 130663-39-7
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Lei Zhang, Baoli Zhang, Ying Yu, Jingfeng Wang, Jian Wu, Yangang Su, Hong Jiang, Yunzeng Zou, Junbo Ge. Angiotensin II Increases HMGB1 Expression in the Myocardium Through AT1 and AT2 Receptors When Under Pressure Overload.
International heart journal.
2021 Jan; 62(1):162-170. doi:
10.1536/ihj.20-384. [PMID: 33455985] - Xiao Chun Li, Xinchun Zhou, Jia Long Zhuo. Evidence for a Physiological Mitochondrial Angiotensin II System in the Kidney Proximal Tubules: Novel Roles of Mitochondrial Ang II/AT1a/O2- and Ang II/AT2/NO Signaling.
Hypertension (Dallas, Tex. : 1979).
2020 07; 76(1):121-132. doi:
10.1161/hypertensionaha.119.13942. [PMID: 32475319] - Aleksandra Piotrowska, Magdalena Chmielewska, Waldemar Andrzejewski, Piotr Dziegiel, Marzenna Podhorska-Okolow. Influence of Angiotensin II on cell viability and apoptosis in rat renal proximal tubular epithelial cells in in vitro studies.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2020 Jul; 21(3):1470320320949850. doi:
10.1177/1470320320949850. [PMID: 32962526] - Yongjun Zhu, Hongwang Cui, Jie Lv, Haiqin Liang, Yanping Zheng, Shanzhi Wang, Min Wang, Huanan Wang, Feng Ye. AT1 and AT2 receptors modulate renal tubular cell necroptosis in angiotensin II-infused renal injury mice.
Scientific reports.
2019 12; 9(1):19450. doi:
10.1038/s41598-019-55550-8. [PMID: 31857626] - Hae Jin Kim, Ji Hyun Jang, Yin Hua Zhang, Hae Young Yoo, Sung Joon Kim. Fast relaxation and desensitization of angiotensin II contraction in the pulmonary artery via AT1R and Akt-mediated phosphorylation of muscular eNOS.
Pflugers Archiv : European journal of physiology.
2019 10; 471(10):1317-1330. doi:
10.1007/s00424-019-02305-z. [PMID: 31468138] - Alexander Renziehausen, Hexiao Wang, Bhavya Rao, Lynda Weir, Cristiana Lo Nigro, Laura Lattanzio, Marco Merlano, Antonio Vega-Rioja, Maria Del Carmen Fernandez-Carranco, Nabil Hajji, Rubeta Matin, Catherine Harwood, Su Li, Van Ren Sim, Kevin O'Neill, Alan Evans, Alastair Thompson, Peter Szlosarek, Colin Fleming, Justin Stebbing, Charlotte Proby, Andreas G Tzakos, Nelofer Syed, Tim Crook. The renin angiotensin system (RAS) mediates bifunctional growth regulation in melanoma and is a novel target for therapeutic intervention.
Oncogene.
2019 03; 38(13):2320-2336. doi:
10.1038/s41388-018-0563-y. [PMID: 30478450] - Jay S Mishra, Kathirvel Gopalakrishnan, Sathish Kumar. Pregnancy upregulates angiotensin type 2 receptor expression and increases blood flow in uterine arteries of rats.
Biology of reproduction.
2018 11; 99(5):1091-1099. doi:
10.1093/biolre/ioy130. [PMID: 29860295] - Wenxia Si, Wen Xie, Wenbing Deng, Yi Xiao, Sadashiva S Karnik, Chengqi Xu, Qiuyun Chen, Qing Kenneth Wang. Angiotensin II increases angiogenesis by NF-κB-mediated transcriptional activation of angiogenic factor AGGF1.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2018 09; 32(9):5051-5062. doi:
10.1096/fj.201701543rr. [PMID: 29641288] - Peng Wu, Zhong-Xiuzi Gao, Xin-Peng Duan, Xiao-Tong Su, Ming-Xiao Wang, Dao-Hong Lin, Ruimin Gu, Wen-Hui Wang. AT2R (Angiotensin II Type 2 Receptor)-Mediated Regulation of NCC (Na-Cl Cotransporter) and Renal K Excretion Depends on the K Channel, Kir4.1.
Hypertension (Dallas, Tex. : 1979).
2018 04; 71(4):622-630. doi:
10.1161/hypertensionaha.117.10471. [PMID: 29483225] - Jin Sug Kim, Gi-Ja Lee, Tae Won Lee, Chun Gyoo Ihm, Yu Ho Lee, Yang Gyun Kim, Ju-Young Moon, Sang Ho Lee, Ji-Hye Kim, Sung-Wook Kang, Su-Jin Chae, Hun-Kuk Park, Kyung Hwan Jeong. Observations of the Effects of Angiotensin II Receptor Blocker on Angiotensin II-Induced Morphological and Mechanical Changes in Renal Tubular Epithelial Cells Using Atomic Force Microscopy.
BioMed research international.
2018; 2018(?):9208795. doi:
10.1155/2018/9208795. [PMID: 29888284] - Sanket N Patel, Quaisar Ali, Preethi Samuel, Ulrike Muscha Steckelings, Tahir Hussain. Angiotensin II Type 2 Receptor and Receptor Mas Are Colocalized and Functionally Interdependent in Obese Zucker Rat Kidney.
Hypertension (Dallas, Tex. : 1979).
2017 10; 70(4):831-838. doi:
10.1161/hypertensionaha.117.09679. [PMID: 28827476] - Santosh Kumar Goru, Almesh Kadakol, Vajir Malek, Anuradha Pandey, Nisha Sharma, Anil Bhanudas Gaikwad. Diminazene aceturate prevents nephropathy by increasing glomerular ACE2 and AT2 receptor expression in a rat model of type1 diabetes.
British journal of pharmacology.
2017 Sep; 174(18):3118-3130. doi:
10.1111/bph.13946. [PMID: 28688122] - Julia Leonhardt, Daniel C Villela, Anke Teichmann, Lisa-Marie Münter, Magnus C Mayer, Maibritt Mardahl, Sebastian Kirsch, Pawel Namsolleck, Kristin Lucht, Verena Benz, Natalia Alenina, Nicholas Daniell, Masatsugu Horiuchi, Masaru Iwai, Gerhard Multhaup, Ralf Schülein, Michael Bader, Robson A Santos, Thomas Unger, Ulrike Muscha Steckelings. Evidence for Heterodimerization and Functional Interaction of the Angiotensin Type 2 Receptor and the Receptor MAS.
Hypertension (Dallas, Tex. : 1979).
2017 06; 69(6):1128-1135. doi:
10.1161/hypertensionaha.116.08814. [PMID: 28461604] - Mohammed H Abdulla, Edward J Johns. The role of brain angiotensin II (type 2) receptors and nitric oxide in the renal sympathoinhibitory response to acute volume expansion in conscious rats.
Journal of hypertension.
2017 02; 35(2):338-347. doi:
10.1097/hjh.0000000000001154. [PMID: 27820727] - Anuradha Pandey, Santosh Kumar Goru, Almesh Kadakol, Vajir Malek, Nisha Sharma, Anil Bhanudas Gaikwad. H2AK119 monoubiquitination regulates Angiotensin II receptor mediated macrophage infiltration and renal fibrosis in type 2 diabetic rats.
Biochimie.
2016 Dec; 131(?):68-76. doi:
10.1016/j.biochi.2016.09.016. [PMID: 27693081] - Angela E Vinturache, Francine G Smith. Renal effects of angiotensin II in the newborn period: role of type 1 and type 2 receptors.
BMC physiology.
2016 Apr; 16(?):3. doi:
10.1186/s12899-016-0022-3. [PMID: 27090941] - A Mansoori, S Oryan, M Nematbakhsh. Role of Mas receptor antagonist (A779) in renal hemodynamics in condition of blocked angiotensin II receptors in rats.
Physiology international.
2016 Mar; 103(1):13-20. doi:
10.1556/036.103.2016.1.2. [PMID: 27030624] - Hui-Lin Guo, Xiao-Hui Liao, Qi Liu, Ling Zhang. Angiotensin II Type 2 Receptor Decreases Transforming Growth Factor-β Type II Receptor Expression and Function in Human Renal Proximal Tubule Cells.
PloS one.
2016; 11(2):e0148696. doi:
10.1371/journal.pone.0148696. [PMID: 26867007] - Mark Del Borgo, Yan Wang, Sanja Bosnyak, Morimer Khan, Pia Walters, Iresha Spizzo, Patrick Perlmutter, Lucinda Hilliard, Kate Denton, Marie-Isabel Aguilar, Robert E Widdop, Emma S Jones. β-Pro7Ang III is a novel highly selective angiotensin II type 2 receptor (AT2R) agonist, which acts as a vasodepressor agent via the AT2R in conscious spontaneously hypertensive rats.
Clinical science (London, England : 1979).
2015 Sep; 129(6):505-13. doi:
10.1042/cs20150077. [PMID: 26186568] - Sofie Brouwers, Ilse Smolders, Richard D Wainford, Alain G Dupont. Hypotensive and sympathoinhibitory responses to selective central AT2 receptor stimulation in spontaneously hypertensive rats.
Clinical science (London, England : 1979).
2015 Jul; 129(1):81-92. doi:
10.1042/cs20140776. [PMID: 25655919] - Shu-Yan Dai, Wei Peng, Yu-Ping Zhang, Jian-Dong Li, Ying Shen, Xiao-Fei Sun. Brain endogenous angiotensin II receptor type 2 (AT2-R) protects against DOCA/salt-induced hypertension in female rats.
Journal of neuroinflammation.
2015 Mar; 12(?):47. doi:
10.1186/s12974-015-0261-4. [PMID: 25885968] - Penghui Yang, Hongjing Gu, Zhongpeng Zhao, Wei Wang, Bin Cao, Chengcai Lai, Xiaolan Yang, LiangYan Zhang, Yueqiang Duan, Shaogeng Zhang, Weiwen Chen, Wenbo Zhen, Maosheng Cai, Josef M Penninger, Chengyu Jiang, Xiliang Wang. Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury.
Scientific reports.
2014 Nov; 4(?):7027. doi:
10.1038/srep07027. [PMID: 25391767] - Russell D Brown, Lucinda M Hilliard, Katrina M Mirabito, Laura C Wirth, Laura C Firth, Karen M Moritz, Roger G Evans, Kate M Denton. Reduced sensitivity of the renal vasculature to angiotensin II in young rats: the role of the angiotensin type 2 receptor.
Pediatric research.
2014 Nov; 76(5):448-52. doi:
10.1038/pr.2014.121. [PMID: 25119338] - A Mansoori, S Oryan, M Nematbakhsh. Role of Mas receptor antagonist (A779) on pressure diuresis and natriuresis and renal blood flow in the absence of angiotensin II receptors type 1 and 2 in female and male rats.
Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
2014 Oct; 65(5):633-9. doi:
. [PMID: 25371522] - Tadashi Yoshida, Tashfin S Huq, Patrice Delafontaine. Angiotensin type 2 receptor signaling in satellite cells potentiates skeletal muscle regeneration.
The Journal of biological chemistry.
2014 Sep; 289(38):26239-26248. doi:
10.1074/jbc.m114.585521. [PMID: 25112871] - Larry D Alexander, Yaxian Ding, Suganthi Alagarsamy, Xiaolan Cui. Angiotensin II stimulates fibronectin protein synthesis via a Gβγ/arachidonic acid-dependent pathway.
American journal of physiology. Renal physiology.
2014 Aug; 307(3):F287-302. doi:
10.1152/ajprenal.00094.2014. [PMID: 24920755] - Bryna S Man Chow, Martina Kocan, Sanja Bosnyak, Mohsin Sarwar, Belinda Wigg, Emma S Jones, Robert E Widdop, Roger J Summers, Ross A D Bathgate, Tim D Hewitson, Chrishan S Samuel. Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis.
Kidney international.
2014 Jul; 86(1):75-85. doi:
10.1038/ki.2013.518. [PMID: 24429402] - Glenn T Nagami, Alexandria K Plumer, Raymond M Beyda, Oran Schachter. Effects of acid challenges on type 2 angiotensin II receptor-sensitive ammonia production by the proximal tubule.
American journal of physiology. Renal physiology.
2014 Jul; 307(1):F53-7. doi:
10.1152/ajprenal.00466.2013. [PMID: 24829505] - Juliana Dias, Fernanda M Ferrão, Flavia Axelband, Adriana K Carmona, Lucienne S Lara, Adalberto Vieyra. ANG-(3-4) inhibits renal Na+-ATPase in hypertensive rats through a mechanism that involves dissociation of ANG II receptors, heterodimers, and PKA.
American journal of physiology. Renal physiology.
2014 Apr; 306(8):F855-63. doi:
10.1152/ajprenal.00488.2013. [PMID: 24523384] - Suang Suang Koid, James Ziogas, Duncan John Campbell. Aliskiren reduces myocardial ischemia-reperfusion injury by a bradykinin B2 receptor- and angiotensin AT2 receptor-mediated mechanism.
Hypertension (Dallas, Tex. : 1979).
2014 Apr; 63(4):768-73. doi:
10.1161/hypertensionaha.113.02902. [PMID: 24420538] - Ying Li, Xiao-Hui Li, Zhi-Jun Huang, Xiao-Hong Tang, Jing-Jing Liu, Hong Yuan. Metoprolol restores expression and vasodilatation function of AT2R in spontaneously hypertensive rats.
Journal of cardiovascular pharmacology.
2014 Mar; 63(3):252-8. doi:
10.1097/fjc.0000000000000042. [PMID: 24193197] - Yushen Jiang, Tang Jiang, Juan Ouyang, Qingsong Zhou, Yanlan Liang, Yingpeng Cui, Peisong Chen, Bin Huang. Cell atavistic transition: Paired box 2 re-expression occurs in mature tubular epithelial cells during acute kidney injury and is regulated by Angiotensin II.
PloS one.
2014; 9(4):e93563. doi:
10.1371/journal.pone.0093563. [PMID: 24710423] - Seung Ah Cha, Byung Mun Park, Shan Gao, Suhn Hee Kim. Stimulation of ANP by angiotensin-(1-9) via the angiotensin type 2 receptor.
Life sciences.
2013 Dec; 93(24):934-40. doi:
10.1016/j.lfs.2013.10.020. [PMID: 24177599] - Sofie Brouwers, Ilse Smolders, Ann Massie, Alain G Dupont. Angiotensin II type 2 receptor-mediated and nitric oxide-dependent renal vasodilator response to compound 21 unmasked by angiotensin-converting enzyme inhibition in spontaneously hypertensive rats in vivo.
Hypertension (Dallas, Tex. : 1979).
2013 Nov; 62(5):920-6. doi:
10.1161/hypertensionaha.112.00762. [PMID: 24041944] - Mohammed H Abdulla, Edward J Johns. Role of angiotensin AT2 receptors and nitric oxide in the cardiopulmonary baroreflex control of renal sympathetic nerve activity in rats.
Journal of hypertension.
2013 Sep; 31(9):1837-46. doi:
10.1097/hjh.0b013e3283622198. [PMID: 23751965] - Shan Gao, Byung Mun Park, Seung Ah Cha, Woo Hyun Park, Byung Hyun Park, Suhn Hee Kim. Angiotensin AT2 receptor agonist stimulates high stretch induced- ANP secretion via PI3K/NO/sGC/PKG/pathway.
Peptides.
2013 Sep; 47(?):36-44. doi:
10.1016/j.peptides.2013.06.008. [PMID: 23791669] - Philip L Johnson, Tammy J Sajdyk, Stephanie D Fitz, Mathew W Hale, Christopher A Lowry, Anders Hay-Schmidt, Anantha Shekhar. Angiotensin II's role in sodium lactate-induced panic-like responses in rats with repeated urocortin 1 injections into the basolateral amygdala: amygdalar angiotensin receptors and panic.
Progress in neuro-psychopharmacology & biological psychiatry.
2013 Jul; 44(?):248-56. doi:
10.1016/j.pnpbp.2013.02.014. [PMID: 23523745] - Byung Mun Park, Young-Bin Oh, Shan Gao, Seung Ah Cha, Kyung Pyo Kang, Suhn Hee Kim. Angiotensin III stimulates high stretch-induced ANP secretion via angiotensin type 2 receptor.
Peptides.
2013 Apr; 42(?):131-7. doi:
10.1016/j.peptides.2013.01.018. [PMID: 23419986] - Mireille Lortie, Jean N DaSilva, Sheryn A Kirkpatrick, Tayebeh Hadizad, Basma A Ismail, Rob S B Beanlands, Robert A deKemp. Analysis of [11C]methyl-candesartan kinetics in the rat kidney for the assessment of angiotensin II type 1 receptor density in vivo with PET.
Nuclear medicine and biology.
2013 Feb; 40(2):252-61. doi:
10.1016/j.nucmedbio.2012.10.013. [PMID: 23352346] - Jiang Xu, Oscar A Carretero, Liping Zhu, Edward G Shesely, Nour-Eddine Rhaleb, Xiangguo Dai, Luchen Wang, James J Yang, Xiao-Ping Yang. Protective role of AT(2) and B(1) receptors in kinin B(2)-receptor-knockout mice with myocardial infarction.
Clinical science (London, England : 1979).
2013 Jan; 124(2):87-96. doi:
10.1042/cs20120341. [PMID: 22849668] - T Safari, M Nematbakhsh, L M Hilliard, R G Evans, K M Denton. Sex differences in the renal vascular response to angiotensin II involves the Mas receptor.
Acta physiologica (Oxford, England).
2012 Oct; 206(2):150-6. doi:
10.1111/j.1748-1716.2012.02468.x. [PMID: 22775972] - Vineet C Chitravanshi, Archana Proddutur, Hreday N Sapru. Cardiovascular actions of angiotensin-(1-12) in the hypothalamic paraventricular nucleus of the rat are mediated via angiotensin II.
Experimental physiology.
2012 Sep; 97(9):1001-17. doi:
10.1113/expphysiol.2011.062471. [PMID: 22125313] - Flavia Axelband, Juliana Dias, Filipe Miranda, Fernanda M Ferrão, Rosana I Reis, Claudio M Costa-Neto, Lucienne S Lara, Adalberto Vieyra. Angiotensin-(3-4) counteracts the Angiotensin II inhibitory action on renal Ca2+-ATPase through a cAMP/PKA pathway.
Regulatory peptides.
2012 Aug; 177(1-3):27-34. doi:
10.1016/j.regpep.2012.04.004. [PMID: 22561691] - Brandon A Kemp, John F Bell, Daniele M Rottkamp, Nancy L Howell, Weijian Shao, L Gabriel Navar, Shetal H Padia, Robert M Carey. Intrarenal angiotensin III is the predominant agonist for proximal tubule angiotensin type 2 receptors.
Hypertension (Dallas, Tex. : 1979).
2012 Aug; 60(2):387-95. doi:
10.1161/hypertensionaha.112.191403. [PMID: 22689743] - Quaisar Ali, Tahir Hussain. AT2 receptor non-peptide agonist C21 promotes natriuresis in obese Zucker rats.
Hypertension research : official journal of the Japanese Society of Hypertension.
2012 Jun; 35(6):654-60. doi:
10.1038/hr.2012.13. [PMID: 22297475] - Divya Salhan, Ankita Sagar, Dileep Kumar, Rungwasee Rattanavich, Partab Rai, Subani Maheshwari, Madhuri Adabala, Mohammad Husain, Guohua Ding, Ashwani Malhotra, Praveen N Chander, Pravin C Singhal. HIV-associated nephropathy: role of AT2R.
Cellular signalling.
2012 Mar; 24(3):734-41. doi:
10.1016/j.cellsig.2011.11.007. [PMID: 22108089] - Shetal H Padia, Brandon A Kemp, Nancy L Howell, Susanna R Keller, John J Gildea, Robert M Carey. Mechanisms of dopamine D(1) and angiotensin type 2 receptor interaction in natriuresis.
Hypertension (Dallas, Tex. : 1979).
2012 Feb; 59(2):437-45. doi:
10.1161/hypertensionaha.111.184788. [PMID: 22203736] - Lucinda M Hilliard, Emma S Jones, U Muscha Steckelings, Thomas Unger, Robert E Widdop, Kate M Denton. Sex-specific influence of angiotensin type 2 receptor stimulation on renal function: a novel therapeutic target for hypertension.
Hypertension (Dallas, Tex. : 1979).
2012 Feb; 59(2):409-14. doi:
10.1161/hypertensionaha.111.184986. [PMID: 22158645] - Sanja Bosnyak, Emma S Jones, Arthur Christopoulos, Marie-Isabel Aguilar, Walter G Thomas, Robert E Widdop. Relative affinity of angiotensin peptides and novel ligands at AT1 and AT2 receptors.
Clinical science (London, England : 1979).
2011 Oct; 121(7):297-303. doi:
10.1042/cs20110036. [PMID: 21542804] - Juan Gao, Hao Zhang, Khang D Le, Jie Chao, Lie Gao. Activation of central angiotensin type 2 receptors suppresses norepinephrine excretion and blood pressure in conscious rats.
American journal of hypertension.
2011 Jun; 24(6):724-30. doi:
10.1038/ajh.2011.33. [PMID: 21394088] - I J Tsai, K D Croft, I B Puddey, L J Beilin, A Barden. 20-Hydroxyeicosatetraenoic acid synthesis is increased in human neutrophils and platelets by angiotensin II and endothelin-1.
American journal of physiology. Heart and circulatory physiology.
2011 Apr; 300(4):H1194-200. doi:
10.1152/ajpheart.00733.2010. [PMID: 21239640] - Emma S Jones, Mark P Del Borgo, Julian F Kirsch, Daniel Clayton, Sanja Bosnyak, Iresha Welungoda, Nicholas Hausler, Sharon Unabia, Patrick Perlmutter, Walter G Thomas, Marie-Isabel Aguilar, Robert E Widdop. A single beta-amino acid substitution to angiotensin II confers AT2 receptor selectivity and vascular function.
Hypertension (Dallas, Tex. : 1979).
2011 Mar; 57(3):570-6. doi:
10.1161/hypertensionaha.110.164301. [PMID: 21300665] - Luis C Matavelli, Jiqian Huang, Helmy M Siragy. Angiotensin AT₂ receptor stimulation inhibits early renal inflammation in renovascular hypertension.
Hypertension (Dallas, Tex. : 1979).
2011 Feb; 57(2):308-13. doi:
10.1161/hypertensionaha.110.164202. [PMID: 21189405] - Lucinda M Hilliard, Mehdi Nematbakhsh, Michelle M Kett, Elleesha Teichman, Amanda K Sampson, Robert E Widdop, Roger G Evans, Kate M Denton. Gender differences in pressure-natriuresis and renal autoregulation: role of the Angiotensin type 2 receptor.
Hypertension (Dallas, Tex. : 1979).
2011 Feb; 57(2):275-82. doi:
10.1161/hypertensionaha.110.166827. [PMID: 21189402] - Young-Bin Oh, Shan Gao, Amin Shah, Jong Hun Kim, Woo Hyun Park, Suhn Hee Kim. Endogenous angiotensin II suppresses stretch-induced ANP secretion via AT1 receptor pathway.
Peptides.
2011 Feb; 32(2):374-81. doi:
10.1016/j.peptides.2010.10.031. [PMID: 21056071] - Wei-Wen Hung, Tusty-Jiuan Hsieh, Tzu Lin, Pong-Chun Chou, Pi-Jung Hsiao, Kun-Der Lin, Shyi-Jang Shin. Blockade of the renin-angiotensin system ameliorates apelin production in 3T3-L1 adipocytes.
Cardiovascular drugs and therapy.
2011 Feb; 25(1):3-12. doi:
10.1007/s10557-010-6274-4. [PMID: 21161354] - José Silva, Mariella Pastorello, Jorge Arzola, Lida E Zavala, Sara De Jesús, Maider Varela, María Gabriela Matos, María del Rosario Garrido, Anita Israel. AT₁ receptor and NAD(P)H oxidase mediate angiotensin II-stimulated antioxidant enzymes and mitogen-activated protein kinase activity in the rat hypothalamus.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
2010 Dec; 11(4):234-42. doi:
10.1177/1470320310376987. [PMID: 20807796] - Robert T Day, Rita de Cássia Cavaglieri, Hooman Tabatabaimir, Vasudha Mantravadi, Myung-Ja Lee, Jeffrey L Barnes, Balakuntalam S Kasinath, Denis Feliers. Acute hyperglycemia rapidly stimulates VEGF mRNA translation in the kidney. Role of angiotensin type 2 receptor (AT2).
Cellular signalling.
2010 Dec; 22(12):1849-57. doi:
10.1016/j.cellsig.2010.07.012. [PMID: 20667471] - Yilin Ren, Martin A D'Ambrosio, Jeffrey L Garvin, Oscar A Carretero. Angiotensin II enhances connecting tubule glomerular feedback.
Hypertension (Dallas, Tex. : 1979).
2010 Oct; 56(4):636-42. doi:
10.1161/hypertensionaha.110.153692. [PMID: 20696981] - Annette Hus-Citharel, Nadine Bouby, Xavier Iturrioz, Catherine Llorens-Cortes. Multiple cross talk between angiotensin II, bradykinin, and insulin signaling in the cortical thick ascending limb of rat kidney.
Endocrinology.
2010 Jul; 151(7):3181-94. doi:
10.1210/en.2009-1237. [PMID: 20463058] - Stephen A Contag, Jianli Bi, Mark C Chappell, James C Rose. Developmental effect of antenatal exposure to betamethasone on renal angiotensin II activity in the young adult sheep.
American journal of physiology. Renal physiology.
2010 Apr; 298(4):F847-56. doi:
10.1152/ajprenal.00497.2009. [PMID: 20071463] - Takashi Naito, Li-Jun Ma, Haichun Yang, Yiqin Zuo, Yiwei Tang, Jee Young Han, Valentina Kon, Agnes B Fogo. Angiotensin type 2 receptor actions contribute to angiotensin type 1 receptor blocker effects on kidney fibrosis.
American journal of physiology. Renal physiology.
2010 Mar; 298(3):F683-91. doi:
10.1152/ajprenal.00503.2009. [PMID: 20042458] - Shetal H Padia, Nancy L Howell, Brandon A Kemp, Marie-Claude Fournie-Zaluski, Bernard P Roques, Robert M Carey. Intrarenal aminopeptidase N inhibition restores defective angiontesin II type 2-mediated natriuresis in spontaneously hypertensive rats.
Hypertension (Dallas, Tex. : 1979).
2010 Feb; 55(2):474-80. doi:
10.1161/hypertensionaha.109.144956. [PMID: 19996063] - TanYa M Gwathmey, Karl D Pendergrass, Sean D Reid, James C Rose, Debra I Diz, Mark C Chappell. Angiotensin-(1-7)-angiotensin-converting enzyme 2 attenuates reactive oxygen species formation to angiotensin II within the cell nucleus.
Hypertension (Dallas, Tex. : 1979).
2010 Jan; 55(1):166-71. doi:
10.1161/hypertensionaha.109.141622. [PMID: 19948986] - Paolo Gelosa, Alice Pignieri, Lars Fändriks, Marc de Gasparo, Anders Hallberg, Cristina Banfi, Laura Castiglioni, Lucia Turolo, Uliano Guerrini, Elena Tremoli, Luigi Sironi. Stimulation of AT2 receptor exerts beneficial effects in stroke-prone rats: focus on renal damage.
Journal of hypertension.
2009 Dec; 27(12):2444-51. doi:
10.1097/hjh.0b013e3283311ba1. [PMID: 19680135] - Ivan Dimitrijevic, Marie-Louise Edvinsson, Qingwen Chen, Malin Malmsjö, Per-Ola Kimblad, Lars Edvinsson. Increased expression of vascular endothelin type B and angiotensin type 1 receptors in patients with ischemic heart disease.
BMC cardiovascular disorders.
2009 Aug; 9(?):40. doi:
10.1186/1471-2261-9-40. [PMID: 19706169] - Tang Jiang, Qing-song Zhou, Lei Pi, Bin Huang. [Role of angiotensin II and JAK2 signal pathway in transdifferentation of renal tubular cells in mice after acute ischemic followed by reperfusion].
Zhonghua bing li xue za zhi = Chinese journal of pathology.
2009 Jul; 38(7):466-71. doi:
. [PMID: 19781194] - Flavia Axelband, Iranaia Assunção-Miranda, Isabela R de Paula, Fernanda M Ferrão, Juliana Dias, Antonio Miranda, Filipe Miranda, Lucienne S Lara, Adalberto Vieyra. Ang-(3-4) suppresses inhibition of renal plasma membrane calcium pump by Ang II.
Regulatory peptides.
2009 Jun; 155(1-3):81-90. doi:
10.1016/j.regpep.2009.03.014. [PMID: 19345245] - Anke Doller, Stefan Gauer, Ewelina Sobkowiak, Helmut Geiger, Josef Pfeilschifter, Wolfgang Eberhardt. Angiotensin II induces renal plasminogen activator inhibitor-1 and cyclooxygenase-2 expression post-transcriptionally via activation of the mRNA-stabilizing factor human-antigen R.
The American journal of pathology.
2009 Apr; 174(4):1252-63. doi:
10.2353/ajpath.2009.080652. [PMID: 19246637] - Shetal H Padia, Brandon A Kemp, Nancy L Howell, John J Gildea, Susanna R Keller, Robert M Carey. Intrarenal angiotensin III infusion induces natriuresis and angiotensin type 2 receptor translocation in Wistar-Kyoto but not in spontaneously hypertensive rats.
Hypertension (Dallas, Tex. : 1979).
2009 Feb; 53(2):338-43. doi:
10.1161/hypertensionaha.108.124198. [PMID: 19075092] - Athar H Siddiqui, Quaisar Ali, Tahir Hussain. Protective role of angiotensin II subtype 2 receptor in blood pressure increase in obese Zucker rats.
Hypertension (Dallas, Tex. : 1979).
2009 Feb; 53(2):256-61. doi:
10.1161/hypertensionaha.108.126086. [PMID: 19114640] - Emaad M Abdel-Rahman, Peter M Abadir, Helmy M Siragy. Regulation of renal 12(S)-hydroxyeicosatetraenoic acid in diabetes by angiotensin AT1 and AT2 receptors.
American journal of physiology. Regulatory, integrative and comparative physiology.
2008 Nov; 295(5):R1473-8. doi:
10.1152/ajpregu.90699.2008. [PMID: 18799632] - Susana I Sánchez, Alicia M Seltzer, Lucia B Fuentes, Myriam L Forneris, Gladys M Ciuffo. Inhibition of Angiotensin II receptors during pregnancy induces malformations in developing rat kidney.
European journal of pharmacology.
2008 Jun; 588(1):114-23. doi:
10.1016/j.ejphar.2008.04.014. [PMID: 18495111] - Toru Kagawa, Toshihiro Takao, Taro Horino, Reiko Matsumoto, Kousuke Inoue, Tatsuhito Morita, Kozo Hashimoto. Angiotensin II receptor blocker inhibits tumour necrosis factor-alpha-induced cell damage in human renal proximal tubular epithelial cells.
Nephrology (Carlton, Vic.).
2008 Jun; 13(4):309-15. doi:
10.1111/j.1440-1797.2008.00918.x. [PMID: 18331441] - Judith Sendra, Vicenta Llorente-Cortés, Paula Costales, Claudia Huesca-Gómez, Lina Badimon. Angiotensin II upregulates LDL receptor-related protein (LRP1) expression in the vascular wall: a new pro-atherogenic mechanism of hypertension.
Cardiovascular research.
2008 Jun; 78(3):581-9. doi:
10.1093/cvr/cvn043. [PMID: 18281370] - Peter Kilian, Shirley Campbell, Lyne Bilodeau, Marie-Odile Guimond, Claude Roberge, Nicole Gallo-Payet, Marcel Daniel Payet. Angiotensin II type 2 receptor stimulation increases the rate of NG108-15 cell migration via actin depolymerization.
Endocrinology.
2008 Jun; 149(6):2923-33. doi:
10.1210/en.2007-0313. [PMID: 18326001] - Helmy M Siragy, Jiqian Huang. Renal (pro)renin receptor upregulation in diabetic rats through enhanced angiotensin AT1 receptor and NADPH oxidase activity.
Experimental physiology.
2008 May; 93(5):709-14. doi:
10.1113/expphysiol.2007.040550. [PMID: 18192338] - Kaoru Iwata, Tetsuro Sohda, Makoto Irie, Yasuaki Takeyama, Akira Anan, Satoshi Shakado, Shotaro Sakisaka. Angiotensin II type 1 receptor antagonist improves the prognosis in rats displaying liver cirrhosis induced by a choline-deficient diet.
Journal of gastrointestinal and liver diseases : JGLD.
2008 Mar; 17(1):21-5. doi:
". [PMID: 18392239] - Fredrik Palm, Stephanie G Connors, Margarida Mendonca, William J Welch, Christopher S Wilcox. Angiotensin II type 2 receptors and nitric oxide sustain oxygenation in the clipped kidney of early Goldblatt hypertensive rats.
Hypertension (Dallas, Tex. : 1979).
2008 Feb; 51(2):345-51. doi:
10.1161/hypertensionaha.107.097832. [PMID: 18158356] - Eirini Nestoridi, Rafail I Kushak, Olga Tsukurov, Eric F Grabowski, Julie R Ingelfinger. Role of the renin angiotensin system in TNF-alpha and Shiga-toxin-induced tissue factor expression.
Pediatric nephrology (Berlin, Germany).
2008 Feb; 23(2):221-31. doi:
10.1007/s00467-007-0636-6. [PMID: 18060435] - Shetal H Padia, Brandon A Kemp, Nancy L Howell, Marie-Claude Fournie-Zaluski, Bernard P Roques, Robert M Carey. Conversion of renal angiotensin II to angiotensin III is critical for AT2 receptor-mediated natriuresis in rats.
Hypertension (Dallas, Tex. : 1979).
2008 Feb; 51(2):460-5. doi:
10.1161/hypertensionaha.107.103242. [PMID: 18158338] - Seiichiro Kano, Kumi Satoh, Shigeru Kaneta, Kazuo Ichihara. Improvement of stunned myocardium in dogs with olmesartan, an angiotensin II type 1 receptor antagonist, is independent of type 2 receptors.
Pharmacology.
2008; 82(1):22-9. doi:
10.1159/000127364. [PMID: 18434761] - Eric P Cohen, Brian L Fish, Mukut Sharma, X Allen Li, John E Moulder. Role of the angiotensin II type-2 receptor in radiation nephropathy.
Translational research : the journal of laboratory and clinical medicine.
2007 Aug; 150(2):106-15. doi:
10.1016/j.trsl.2007.03.004. [PMID: 17656330] - Yong-jian Yang, Han-min Liu, Xin Zhang, Ji-hong Zhang. [Signal transductional mechanism of calpain involved in the regulation of rat hypertrophy myocardium mediated by overloaded pressure].
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition.
2007 Jul; 38(4):599-602, 648. doi:
. [PMID: 17718420] - Nicole Schupp, Ursula Schmid, Przemyslaw Rutkowski, Ursula Lakner, Nilesh Kanase, August Heidland, Helga Stopper. Angiotensin II-induced genomic damage in renal cells can be prevented by angiotensin II type 1 receptor blockage or radical scavenging.
American journal of physiology. Renal physiology.
2007 May; 292(5):F1427-34. doi:
10.1152/ajprenal.00458.2006. [PMID: 17229674] - Hongwei Li, Yongxin Gao, Justin L Grobe, Mohan K Raizada, Michael J Katovich, Colin Sumners. Potentiation of the antihypertensive action of losartan by peripheral overexpression of the ANG II type 2 receptor.
American journal of physiology. Heart and circulatory physiology.
2007 Feb; 292(2):H727-35. doi:
10.1152/ajpheart.00938.2006. [PMID: 17085538] - Mona L Chappellaz, Francine G Smith. Systemic and renal hemodynamic effects of the AT1 receptor antagonist, ZD 7155, and the AT2 receptor antagonist, PD 123319, in conscious lambs.
Pflugers Archiv : European journal of physiology.
2007 Jan; 453(4):477-86. doi:
10.1007/s00424-006-0148-4. [PMID: 17051392] - Leslie J Salomone, Nancy L Howell, Helen E McGrath, Brandon A Kemp, Susanna R Keller, John J Gildea, Robin A Felder, Robert M Carey. Intrarenal dopamine D1-like receptor stimulation induces natriuresis via an angiotensin type-2 receptor mechanism.
Hypertension (Dallas, Tex. : 1979).
2007 Jan; 49(1):155-61. doi:
10.1161/01.hyp.0000251881.89610.ee. [PMID: 17116755] - Márcio A F de Godoy, Satish Rattan. Translocation of AT1- and AT2-receptors by higher concentrations of angiotensin II in the smooth muscle cells of rat internal anal sphincter.
The Journal of pharmacology and experimental therapeutics.
2006 Dec; 319(3):1088-95. doi:
10.1124/jpet.106.108084. [PMID: 16985169] - E Joly, R Seqqat, B Flamion, N Caron, A Michel, J D Imig, R Kramp. Increased renal vascular reactivity to ANG II after unilateral nephrectomy in the rat involves 20-HETE.
American journal of physiology. Regulatory, integrative and comparative physiology.
2006 Oct; 291(4):R977-86. doi:
10.1152/ajpregu.00401.2005. [PMID: 16675634] - Rajash K Handa. Biphasic actions of angiotensin IV on renal blood flow in the rat.
Regulatory peptides.
2006 Sep; 136(1-3):23-9. doi:
10.1016/j.regpep.2006.04.008. [PMID: 16780972] - J Lutz, K Risch, S Liu, B Antus, C Schmaderer, M Roos, N Ouyang, M Lehmann, U Heemann. Angiotensin type 1 and type 2 receptor blockade in chronic allograft nephropathy.
Kidney international.
2006 Sep; 70(6):1080-8. doi:
10.1038/sj.ki.5001709. [PMID: 16850018] - Lijun Shi, Caiping Mao, Jiawei Wu, Paul Morrissey, Juanxiu Lee, Zhice Xu. Effects of i.c.v. losartan on the angiotensin II-mediated vasopressin release and hypothalamic fos expression in near-term ovine fetuses.
Peptides.
2006 Sep; 27(9):2230-8. doi:
10.1016/j.peptides.2006.03.013. [PMID: 16677737] - Xiao C Li, Oscar A Carretero, L Gabriel Navar, Jia L Zhuo. AT1 receptor-mediated accumulation of extracellular angiotensin II in proximal tubule cells: role of cytoskeleton microtubules and tyrosine phosphatases.
American journal of physiology. Renal physiology.
2006 Aug; 291(2):F375-83. doi:
10.1152/ajprenal.00405.2005. [PMID: 16478976] - Zia Shariat-Madar, Fakhri Mahdi, Mark Warnock, Jonathon W Homeister, Sujata Srikanth, Yelena Krijanovski, Laine J Murphey, Ayad A Jaffa, Alvin H Schmaier. Bradykinin B2 receptor knockout mice are protected from thrombosis by increased nitric oxide and prostacyclin.
Blood.
2006 Jul; 108(1):192-9. doi:
10.1182/blood-2006-01-0094. [PMID: 16514058] - Ekaterini Angelis, M Yat Tse, Michael A Adams, Stephen C Pang. Effect of AT2 blockade on cardiac hypertrophy as induced by high dietary salt in the proatrial natriuretic peptide (ANP) gene-disrupted mouse.
Canadian journal of physiology and pharmacology.
2006 Jun; 84(6):625-34. doi:
10.1139/y06-016. [PMID: 16900247] - Amer C Hakam, Tahir Hussain. Angiotensin II type 2 receptor agonist directly inhibits proximal tubule sodium pump activity in obese but not in lean Zucker rats.
Hypertension (Dallas, Tex. : 1979).
2006 Jun; 47(6):1117-24. doi:
10.1161/01.hyp.0000220112.91724.fc. [PMID: 16618840] - Jianmin Ran, Tsutomu Hirano, Tomoyasu Fukui, Kiyomi Saito, Haruaki Kageyama, Kenta Okada, Mitsuru Adachi. Angiotensin II infusion decreases plasma adiponectin level via its type 1 receptor in rats: an implication for hypertension-related insulin resistance.
Metabolism: clinical and experimental.
2006 Apr; 55(4):478-88. doi:
10.1016/j.metabol.2005.10.009. [PMID: 16546478] - Shetal H Padia, Nancy L Howell, Helmy M Siragy, Robert M Carey. Renal angiotensin type 2 receptors mediate natriuresis via angiotensin III in the angiotensin II type 1 receptor-blocked rat.
Hypertension (Dallas, Tex. : 1979).
2006 Mar; 47(3):537-44. doi:
10.1161/01.hyp.0000196950.48596.21. [PMID: 16380540]