ICI 164384 (BioDeep_00000010132)
代谢物信息卡片
ICI 164384; N-n-Butyl-N-methyl-11-[3,17beta-dihydroxyestra-1,3,5(10)-trien-7alpha-yl]undecanamide
化学式: C34H55NO3 (525.418172)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCCCN(C)C(=O)CCCCCCCCCCC1CC2=C(C=CC(=C2)O)C3C1C4CCC(C4(CC3)C)O
InChI: InChI=1S/C34H55NO3/c1-4-5-22-35(3)32(38)15-13-11-9-7-6-8-10-12-14-25-23-26-24-27(36)16-17-28(26)29-20-21-34(2)30(33(25)29)18-19-31(34)37/h16-17,24-25,29-31,33,36-37H,4-15,18-23H2,1-3H3/t25-,29-,30+,31+,33-,34+/m1/s1
描述信息
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006727 - Hormone Antagonists > D004965 - Estrogen Antagonists
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
同义名列表
数据库引用编号
11 个数据库交叉引用编号
- ChEBI: CHEBI:40710
- KEGG: C14758
- PubChem: 104772
- Metlin: METLIN70312
- DrugBank: DB03860
- ChEMBL: CHEMBL1222035
- CAS: 98007-99-9
- PMhub: MS000023968
- PubChem: 17395756
- PDB-CCD: AOE
- NIKKAJI: J367.470C
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Patrick S Y Wong, Fumio Matsumura. Serum free BG-1 cell proliferation assay: a sensitive method for determining organochlorine pesticide estrogen receptor activation at the nanomolar range.
Toxicology in vitro : an international journal published in association with BIBRA.
2006 Apr; 20(3):382-94. doi:
10.1016/j.tiv.2005.08.016. [PMID: 16242299] - Ian M Dick, Jie Liu, Paul Glendenning, Richard L Prince. Estrogen and androgen regulation of plasma membrane calcium pump activity in immortalized distal tubule kidney cells.
Molecular and cellular endocrinology.
2003 Dec; 212(1-2):11-8. doi:
10.1016/j.mce.2003.09.028. [PMID: 14654246] - Florence Trémollières, Patrice Lopes. [Specific estrogen receptor modulators (SERMs)].
Presse medicale (Paris, France : 1983).
2002 Sep; 31(28):1323-8. doi:
". [PMID: 12355995] - Sumi Dinda, Amelita Sanchez, Virinder Moudgil. Estrogen-like effects of thyroid hormone on the regulation of tumor suppressor proteins, p53 and retinoblastoma, in breast cancer cells.
Oncogene.
2002 Jan; 21(5):761-8. doi:
10.1038/sj.onc.1205136. [PMID: 11850804] - M Luconi, L Bonaccorsi, G Forti, E Baldi. Effects of estrogenic compounds on human spermatozoa: evidence for interaction with a nongenomic receptor for estrogen on human sperm membrane.
Molecular and cellular endocrinology.
2001 Jun; 178(1-2):39-45. doi:
10.1016/s0303-7207(01)00416-6. [PMID: 11403892] - A E Elkak, K Mokbel. Pure antiestrogens and breast cancer.
Current medical research and opinion.
2001; 17(4):282-9. doi:
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The Journal of steroid biochemistry and molecular biology.
2000 Nov; 74(4):223-34. doi:
10.1016/s0960-0760(00)00126-6. [PMID: 11162928] - S Nishimura, M Taki, S Takaishi, Y Iijima, T Akiyama. Structures of 4-aryl-coumarin (neoflavone) dimers isolated from Pistacia chinensis BUNGE and their estrogen-like activity.
Chemical & pharmaceutical bulletin.
2000 Apr; 48(4):505-8. doi:
10.1248/cpb.48.505. [PMID: 10783069] - Y L Dong, C Yallampalli. Pregnancy and exogenous steroid treatments modulate the expression of relaxant EP(2) and contractile FP receptors in the rat uterus.
Biology of reproduction.
2000 Mar; 62(3):533-9. doi:
10.1095/biolreprod62.3.533. [PMID: 10684792] - R L van Bezooijen, I Que, A G Ederveen, H J Kloosterboer, S E Papapoulos, C W Löwik. Plasma nitrate+nitrite levels are regulated by ovarian steroids but do not correlate with trabecular bone mineral density in rats.
The Journal of endocrinology.
1998 Oct; 159(1):27-34. doi:
10.1677/joe.0.1590027. [PMID: 9795338] - Y L Dong, L Fang, P R Gangula, C Yallampalli. Regulation of inducible nitric oxide synthase messenger ribonucleic acid expression in pregnant rat uterus.
Biology of reproduction.
1998 Oct; 59(4):933-40. doi:
10.1095/biolreprod59.4.933. [PMID: 9746746] - P T Ram, T Kiefer, M Silverman, Y Song, G M Brown, S M Hill. Estrogen receptor transactivation in MCF-7 breast cancer cells by melatonin and growth factors.
Molecular and cellular endocrinology.
1998 Jun; 141(1-2):53-64. doi:
10.1016/s0303-7207(98)00095-1. [PMID: 9723886] - B Varriale, J Alvarez, F Prieto, P Domínguez. Hormonal regulation of FHG22 mRNA in Syrian hamster harderian glands: role of estradiol.
Molecular and cellular endocrinology.
1996 Nov; 124(1-2):87-96. doi:
10.1016/s0303-7207(96)03932-9. [PMID: 9027328] - C M Tellería, C O Stocco, A O Stati, A M Rastrilla, D G Carrizo, L I Aguado, R P Deis. Dual regulation of luteal progesterone production by androstenedione during spontaneous and RU486-induced luteolysis in pregnant rats.
The Journal of steroid biochemistry and molecular biology.
1995 Dec; 55(3-4):385-93. doi:
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Molecular endocrinology (Baltimore, Md.).
1995 Jun; 9(6):659-69. doi:
10.1210/mend.9.6.8592512. [PMID: 8592512] - G Vollmer, N Ellerbrake, A C Hopert, R Knauthe, W Wünsche, R Knuppen. Extracellular matrix induces hormone responsiveness and differentiation in RUCA-I rat endometrial adenocarcinoma cells.
The Journal of steroid biochemistry and molecular biology.
1995 Mar; 52(3):259-69. doi:
10.1016/0960-0760(94)00173-j. [PMID: 7696147] - H Wiseman, B Halliwell. Tamoxifen and related compounds protect against lipid peroxidation in isolated nuclei: relevance to the potential anticarcinogenic benefits of breast cancer prevention and therapy with tamoxifen?.
Free radical biology & medicine.
1994 Nov; 17(5):485-8. doi:
10.1016/0891-5849(94)90176-7. [PMID: 7835756] - V Cavaillès, S Dauvois, P S Danielian, M G Parker. Interaction of proteins with transcriptionally active estrogen receptors.
Proceedings of the National Academy of Sciences of the United States of America.
1994 Oct; 91(21):10009-13. doi:
10.1073/pnas.91.21.10009. [PMID: 7937828] - V L Davis, J F Couse, T K Gray, K S Korach. Correlation between low levels of estrogen receptors and estrogen responsiveness in two rat osteoblast-like cell lines.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
1994 Jul; 9(7):983-91. doi:
10.1002/jbmr.5650090705. [PMID: 7942167] - C J Newton, T Trapp, U Pagotto, U Renner, R Buric, G K Stalla. The oestrogen receptor modulates growth of pituitary tumour cells in the absence of exogenous oestrogen.
Journal of molecular endocrinology.
1994 Jun; 12(3):303-12. doi:
10.1677/jme.0.0120303. [PMID: 7916969] - R J Miksicek. Interaction of naturally occurring nonsteroidal estrogens with expressed recombinant human estrogen receptor.
The Journal of steroid biochemistry and molecular biology.
1994 Jun; 49(2-3):153-60. doi:
10.1016/0960-0760(94)90005-1. [PMID: 8031711] - S D McLeod, M Ranson, R S Mason. Effects of estrogens on human melanocytes in vitro.
The Journal of steroid biochemistry and molecular biology.
1994 May; 49(1):9-14. doi:
10.1016/0960-0760(94)90295-x. [PMID: 8003445] - D P McDonnell, M E Goldman. RU486 exerts antiestrogenic activities through a novel progesterone receptor A form-mediated mechanism.
The Journal of biological chemistry.
1994 Apr; 269(16):11945-9. doi:
. [PMID: 8163495] - C J Newton, R Buric, T Trapp, S Brockmeier, U Pagotto, G K Stalla. The unliganded estrogen receptor (ER) transduces growth factor signals.
The Journal of steroid biochemistry and molecular biology.
1994 Apr; 48(5-6):481-6. doi:
10.1016/0960-0760(94)90197-x. [PMID: 8180109] - H Wiseman. The antioxidant action of a pure antioestrogen: ability to inhibit lipid peroxidation compared to tamoxifen and 17 beta-oestradiol and relevance to its anticancer potential.
Biochemical pharmacology.
1994 Feb; 47(3):493-8. doi:
10.1016/0006-2952(94)90180-5. [PMID: 8117317] - C K Watts, K J Sweeney, A Warlters, E A Musgrove, R L Sutherland. Antiestrogen regulation of cell cycle progression and cyclin D1 gene expression in MCF-7 human breast cancer cells.
Breast cancer research and treatment.
1994; 31(1):95-105. doi:
10.1007/bf00689680. [PMID: 7981461] - Y Nishino, M R Schneider, H Michna. Enhancement of the antitumor efficacy of the antiprogestin, onapristone, by combination with the antiestrogen, ICI 164384.
Journal of cancer research and clinical oncology.
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Molecular and cellular biology.
1993 Jun; 13(6):3577-87. doi:
10.1128/mcb.13.6.3577-3587.1993. [PMID: 8497271] - L Markiewicz, J Garey, H Adlercreutz, E Gurpide. In vitro bioassays of non-steroidal phytoestrogens.
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1993 May; 45(5):399-405. doi:
10.1016/0960-0760(93)90009-l. [PMID: 8499347] - S J Santner, B Ohlsson-Wilhelm, R J Santen. Estrone sulfate promotes human breast cancer cell replication and nuclear uptake of estradiol in MCF-7 cell cultures.
International journal of cancer.
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1992 Sep; 28A(9-10):595-602. doi:
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1992 May; 89(10):4658-62. doi:
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British journal of cancer.
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