Garcinone E (BioDeep_00000017436)

 

Secondary id: BioDeep_00000618364

human metabolite PANOMIX_OTCML-2023


代谢物信息卡片


9H-Xanthen-9-one, 2,3,6,8-tetrahydroxy-1,4,7-tris(3-methyl-2-buten-1-yl)-

化学式: C28H32O6 (464.2198772)
中文名称: 伽升沃E
谱图信息: 最多检出来源 Chinese Herbal Medicine(otcml) 2.22%

分子结构信息

SMILES: CC(=CCC1=C(C2=C(C=C1O)OC3=C(C(=C(C(=C3C2=O)CC=C(C)C)O)O)CC=C(C)C)O)C
InChI: InChI=1S/C28H32O6/c1-14(2)7-10-17-20(29)13-21-23(24(17)30)27(33)22-18(11-8-15(3)4)25(31)26(32)19(28(22)34-21)12-9-16(5)6/h7-9,13,29-32H,10-12H2,1-6H3

描述信息

Garcinone E is a member of xanthones.
Garcinone E is a natural product found in Garcinia xipshuanbannaensis, Pentadesma butyracea, and other organisms with data available.
See also: Garcinia mangostana fruit rind (has part).
Constituent of the fruit of Garcinia mangostana (mangosteen). Garcinone E is found in fruits and purple mangosteen.
Garcinone E is found in fruits. Garcinone E is a constituent of the fruit of Garcinia mangostana (mangosteen).

同义名列表

12 个代谢物同义名

9H-Xanthen-9-one, 2,3,6,8-tetrahydroxy-1,4,7-tris(3-methyl-2-buten-1-yl)-; 2,3,6,8-TETRAHYDROXY-1,4,7-TRIS(3-METHYLBUT-2-EN-1-YL)-9H-XANTHEN-9-ONE; 1,4,7-Tris(3-methylbut-2-enyl)-2,3,6,8-tetrakis(oxidanyl)xanthen-9-one; 2,3,6,8-tetrahydroxy-1,4,7-tris(3-methylbut-2-enyl)xanthen-9-one; 7-O-DEMETHYL-5-PRENYL-.ALPHA.-MANGOSTIN; 7-O-Demethyl-5-prenyl-alpha-mangostin; UNII-83JJA5L4ZG; MEGxp0_001391; ACon0_000339; ACon1_001486; Garcinone E; 83JJA5L4ZG



数据库引用编号

12 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Jingjing Li, Xin Nie, Panthakarn Rangsinth, Xiaoping Wu, Chengwen Zheng, Yanfen Cheng, Polly Ho-Ting Shiu, Renkai Li, Simon Ming-Yuen Lee, Chaomei Fu, Jinming Zhang, George Pak-Heng Leung. Structure and activity relationship analysis of xanthones from mangosteen: Identifying garcinone E as a potent dual EGFR and VEGFR2 inhibitor. Phytomedicine : international journal of phytotherapy and phytopharmacology. 2024 Jan; 122(?):155140. doi: 10.1016/j.phymed.2023.155140. [PMID: 37939410]
  • Xin Nie, Li Fu, Yanfen Cheng, Xiaoping Wu, Kongpeng Lv, Renkai Li, Yihan Wu, George Pak-Heng Leung, Chaomei Fu, Simon Ming-Yuen Lee, Sai-Wang Seto, Jinming Zhang, Jingjing Li. Garcinone E suppresses breast cancer growth and metastasis by modulating tumor-associated macrophages polarization via STAT6 signaling. Phytotherapy research : PTR. 2023 May; ?(?):. doi: 10.1002/ptr.7909. [PMID: 37259475]
  • Gamal A Mohamed, Sabrin R M Ibrahim, Rawan H Hareeri, Lenah S Binmahfouz, Amina M Bagher, Hossam M Abdallah, Wael M Elsaed, Dina S El-Agamy. Garcinone E Mitigates Oxidative Inflammatory Response and Protects against Experimental Autoimmune Hepatitis via Modulation of Nrf2/HO-1, NF-κB and TNF-α/JNK Axis. Nutrients. 2022 Dec; 15(1):. doi: 10.3390/nu15010016. [PMID: 36615674]
  • Xiaojia Liu, Jianzhong Shen, Kui Zhu. Antibacterial activities of plant-derived xanthones. RSC medicinal chemistry. 2022 Feb; 13(2):107-116. doi: 10.1039/d1md00351h. [PMID: 35308024]
  • He Zhong Jiang, Xiao Fang Quan, Wei Xi Tian, Jiang Miao Hu, Peng Cheng Wang, Sheng Zhuo Huang, Zhong Quan Cheng, Wen Juan Liang, Jun Zhou, Xiao Feng Ma, You Xing Zhao. Fatty acid synthase inhibitors of phenolic constituents isolated from Garcinia mangostana. Bioorganic & medicinal chemistry letters. 2010 Oct; 20(20):6045-7. doi: 10.1016/j.bmcl.2010.08.061. [PMID: 20817450]
  • Fabien Zelefack, David Guilet, Nicolas Fabre, Christine Bayet, Séverine Chevalley, Silvère Ngouela, Bruno Ndjakou Lenta, Alexis Valentin, Etienne Tsamo, Marie-Geneviève Dijoux-Franca. Cytotoxic and antiplasmodial xanthones from Pentadesma butyracea. Journal of natural products. 2009 May; 72(5):954-7. doi: 10.1021/np8005953. [PMID: 19296616]
  • Chi-Kuan Ho, Yu-Ling Huang, Chieh-Chih Chen. Garcinone E, a xanthone derivative, has potent cytotoxic effect against hepatocellular carcinoma cell lines. Planta medica. 2002 Nov; 68(11):975-9. doi: 10.1055/s-2002-35668. [PMID: 12451486]