Dodecenedioate (C12:1-DC) (BioDeep_00000395530)
Main id: BioDeep_00000011113
human metabolite PANOMIX_OTCML-2023 Endogenous blood metabolite
代谢物信息卡片
化学式: C12H20O4 (228.1362)
中文名称: 愈伤酸, 2E-十二碳烯二酸
谱图信息:
最多检出来源 not specific(not specific) 0%
Last reviewed on 2024-09-13.
Cite this Page
Dodecenedioate (C12:1-DC). BioDeep Database v3. PANOMIX ltd, a top metabolomics service provider from China.
https://query.biodeep.cn/s/dodecenedioate_(c12:1-dc) (retrieved
2024-12-23) (BioDeep RN: BioDeep_00000395530). Licensed
under the Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0).
分子结构信息
SMILES: C(CC(=O)O)CCCCCC/C=C/C(=O)O
InChI: InChI=1S/C12H20O4/c13-11(14)9-7-5-3-1-2-4-6-8-10-12(15)16/h7,9H,1-6,8,10H2,(H,13,14)(H,15,16)/b9-7+
描述信息
Traumatic acid is a monounsaturated dicarboxylic acid naturally ocurring in plants. The compound was first isolated from wounded bean plants by American chemists James English Jr. and James Frederick Bonner and Dutch scientist Aire Jan Haagen-Smit in 1939. Traumatic acid is a potent wound healing agent in plants ("wound hormone") that stimulates cell division near a trauma site to form a protective callus and to heal the damaged tissue. It may also act as a growth hormone, especially in inferior plants (e.g. algae). Traumatic acid is biosynthesized in plants by non-enzimatic oxidation of traumatin (12-oxo-trans-10-dodecanoic acid), another wound hormone. At normal conditions, traumatic acid is a solid, crystalized, water insoluble substance.
Traumatic acid is a monounsaturated straight-chain dicarboxylic acid with the double bond at C-2; a plant wound-healing hormone. It has a role as a plant hormone.
Traumatic acid is a natural product found in Meehania urticifolia with data available.
Traumatic Acid is a wound healing agent and a cytokinin (phytohormone). Traumatic Acid enhances the biosynthesis of collagen in cultured human skin fibroblasts. Traumatic Acid inhibits MCF-7 breast cancer cells viability and enhances apoptosis and oxidative stress. Traumatic Acid can be used in studies of cancer, circulatory disorders (including arterial hypertension), and skin diseases associated with oxidative stress and impaired collagen biosynthesis[1][2].
Traumatic Acid is a wound healing agent and a cytokinin (phytohormone). Traumatic Acid enhances the biosynthesis of collagen in cultured human skin fibroblasts. Traumatic Acid inhibits MCF-7 breast cancer cells viability and enhances apoptosis and oxidative stress. Traumatic Acid can be used in studies of cancer, circulatory disorders (including arterial hypertension), and skin diseases associated with oxidative stress and impaired collagen biosynthesis[1][2].
同义名列表
44 个代谢物同义名
TRAUMATIC ACID FOR PROSTAGLANDIN 99\\%; 2-dodecene-1,12-dicarboxylic acid; trans-2-Dodecene-1,12-dioic Acid; 1-Decene-1,10-dicarboxylic acid; trans-2-Dodecene-dioic acid; (2E)-2-Dodecenedioic acid #; 2-Dodecenedioic acid, (2E)-; trans-2-dodecenedioic acid; (2E)-dodec-2-enedioic acid; 2-Dodecenedioic acid, (E)-; (E)-dodec-2-enedioic acid; (Z)-2-dodecenedioic acid; Dodecanedioic acid-2-ene; (2E)-Dodecenedioic acid; 2(E)-dodecenedioic acid; trans-2-dodecenedioate; dodec-2t-enedioic acid; dodec-2c-enedioic acid; 2E-dodecenedioic acid; Dodec-2-enedioic acid; 2-Dodecenedioic acid; trans-Traumatic acid; (Z)-2-dodecenedioate; 2-dodecendioic acid; (2E)-Dodecenedioate; TRAUMATIC ACID [MI]; dodec-2c-enedioate; dodec-2t-enedioate; DODECANEDIOIC ACID; 2E-dodecenedioate; dodec-2-enedioate; Trans-traumatate; 2-Dodecenedioate; UNII-L7ND24937H; 2-dodecendioate; trau-matic acid; Dodecanedioate; Traumatic Acid; TRAUMATICACID; FA 12:2;O2; L7ND24937H; Traumatate; Traumatic acid; Traumatic acid
数据库引用编号
20 个数据库交叉引用编号
- ChEBI: CHEBI:545687
- KEGG: C16308
- PubChem: 5283028
- HMDB: HMDB0000933
- ChEMBL: CHEMBL470062
- Wikipedia: Traumatic_acid
- Wikipedia: Traumatic acid
- LipidMAPS: LMFA01170002
- MeSH: traumatic acid
- ChemIDplus: 0006402364
- foodb: FDB006541
- chemspider: 4446155
- CAS: 6402-36-4
- medchemexpress: HY-119358
- PubChem: 47205616
- NIKKAJI: J5.789D
- RefMet: Traumatic acid
- KNApSAcK: 545687
- LOTUS: LTS0103791
- wikidata: Q105160594
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
- 9606 - Homo sapiens: -
- 672825 - Meehania urticifolia: 10.1007/S11418-010-0501-Y
- 33090 - Plants: -
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Jianfang Gao, Zhongxiao Zhang, Xiaohua Dong, Jing Zhao, Zhou Peng, Ling Zhang, Zhongqing Xu, Liling Xu, Xingyun Wang, Xirong Guo. Traumatic acid inhibits ACSL4 associated lipid accumulation in adipocytes to attenuate high-fat diet-induced obesity.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2023 12; 37(12):e23278. doi:
10.1096/fj.202301166r. [PMID: 37902573] - Jaw-Shiun Tsai, San-Yuan Wang, Chin-Hao Chang, Chin-Ying Chen, Chiung-Jung Wen, Guan-Yuan Chen, Ching-Hua Kuo, Y Jane Tseng, Ching-Yu Chen. Identification of traumatic acid as a potential plasma biomarker for sarcopenia using a metabolomics-based approach.
Journal of cachexia, sarcopenia and muscle.
2022 02; 13(1):276-286. doi:
10.1002/jcsm.12895. [PMID: 34939349] - Agata Jabłońska-Trypuć, Rafał Krętowski, Elżbieta Wołejko, Urszula Wydro, Andrzej Butarewicz. Traumatic acid toxicity mechanisms in human breast cancer MCF-7 cells.
Regulatory toxicology and pharmacology : RTP.
2019 Aug; 106(?):137-146. doi:
10.1016/j.yrtph.2019.04.023. [PMID: 31055047] - Agata Jabłońska-Trypuć, Urszula Wydro, Elżbieta Wołejko, Andrzej Butarewicz. Toxicological Effects of Traumatic Acid and Selected Herbicides on Human Breast Cancer Cells: In Vitro Cytotoxicity Assessment of Analyzed Compounds.
Molecules (Basel, Switzerland).
2019 May; 24(9):. doi:
10.3390/molecules24091710. [PMID: 31052542] - Agata Jabłońska-Trypuć, Walentyn Pankiewicz, Romuald Czerpak. Traumatic Acid Reduces Oxidative Stress and Enhances Collagen Biosynthesis in Cultured Human Skin Fibroblasts.
Lipids.
2016 09; 51(9):1021-35. doi:
10.1007/s11745-016-4174-5. [PMID: 27423205] - E V Asafova, G A Asaleeva, V G Yakovleva, I A Tarchevskii. The effect of traumatic acid on tyrosine phosphorylation of proteins in pea seedlings.
Doklady. Biochemistry and biophysics.
2005 Nov; 405(?):426-8. doi:
10.1007/s10628-005-0131-6. [PMID: 16480144]
