N-Hydroxy-L-asparagine (BioDeep_00001869679)

Main id: BioDeep_00000005100

 


代谢物信息卡片


L-Asparagine,N-hydroxy-

化学式: C4H8N2O4 (148.0484)
中文名称: L-天冬氨酰-β-异羟肟酸
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(C(C(=O)O)N)C(=O)NO
InChI: InChI=1S/C4H8N2O4/c5-2(4(8)9)1-3(7)6-10/h2,10H,1,5H2,(H,6,7)(H,8,9)/t2-/m0/s1

描述信息

D000890 - Anti-Infective Agents > D000998 - Antiviral Agents
D000970 - Antineoplastic Agents

同义名列表

2 个代谢物同义名

L-Asparagine,N-hydroxy-; N-Hydroxy-L-asparagine



数据库引用编号

8 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 11 ACE, BCL2, CASP3, CASP9, DAO, GLUL, GUCY1A1, MST1, SGCB, SRR, VEGFA
Peripheral membrane protein 1 DAO
Endoplasmic reticulum membrane 1 BCL2
Nucleus 6 BCL2, CASP3, CASP9, GLUL, MST1, VEGFA
cytosol 10 ASPG, BCL2, CASP3, CASP9, DAO, GLUL, GUCY1A1, MST1, RPE, SRR
dendrite 1 SLC1A1
nuclear body 1 MST1
nucleoplasm 2 CASP3, MST1
Cell membrane 6 ACE, DAO, GLUL, GRID1, SLC1A1, SLC1A2
Lipid-anchor 1 GLUL
Early endosome membrane 1 SLC1A1
Multi-pass membrane protein 3 GRID1, SLC1A1, SLC1A2
Synapse 1 SLC1A1
cell surface 3 EPO, SLC1A2, VEGFA
dendritic shaft 1 SLC1A1
glutamatergic synapse 4 CASP3, GRID1, GUCY1A1, SLC1A2
Golgi apparatus 1 VEGFA
neuronal cell body 3 CASP3, SLC1A1, SRR
presynaptic membrane 1 SLC1A2
sarcolemma 1 SGCB
Cytoplasm, cytosol 2 DAO, GLUL
Lysosome 1 ACE
Presynapse 1 SLC1A1
endosome 1 ACE
plasma membrane 7 ACE, DAO, GLUL, GRID1, SGCB, SLC1A1, SLC1A2
presynaptic active zone 1 DAO
Membrane 5 ACE, BCL2, SLC1A1, SLC1A2, VEGFA
apical plasma membrane 1 SLC1A1
axon 1 SLC1A1
extracellular exosome 7 ACE, DAO, EPO, GLUL, GRID1, RPE, SLC1A1
endoplasmic reticulum 4 BCL2, GLUL, SLC1A1, VEGFA
extracellular space 5 ACE, DAO, EPO, MST1, VEGFA
Schaffer collateral - CA1 synapse 1 SLC1A1
adherens junction 1 VEGFA
bicellular tight junction 1 DAO
mitochondrion 3 BCL2, CASP9, GLUL
protein-containing complex 3 BCL2, CASP9, MST1
postsynaptic density 1 CASP3
Single-pass type I membrane protein 1 ACE
Secreted 4 ACE, DAO, EPO, VEGFA
extracellular region 5 ACE, DAO, EPO, MST1, VEGFA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 1 BCL2
Extracellular side 1 DAO
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 ACE, SLC1A1
Secreted, extracellular space, extracellular matrix 1 VEGFA
dendritic spine 1 SLC1A1
perikaryon 1 SLC1A1
apical part of cell 1 SRR
Single-pass type II membrane protein 1 SGCB
vesicle 1 SLC1A2
postsynaptic membrane 1 GRID1
Apical cell membrane 1 SLC1A1
Cell membrane, sarcolemma 1 SGCB
Membrane raft 2 SLC1A1, SLC1A2
pore complex 1 BCL2
Cytoplasm, cytoskeleton 1 SGCB
axolemma 1 SLC1A2
GABA-ergic synapse 2 GRID1, GUCY1A1
extracellular matrix 1 VEGFA
Peroxisome 1 DAO
Peroxisome matrix 1 DAO
peroxisomal matrix 1 DAO
collagen-containing extracellular matrix 1 MST1
secretory granule 1 VEGFA
Postsynaptic cell membrane 1 GRID1
neuron projection 1 SLC1A1
Late endosome membrane 1 SLC1A1
cell projection 1 DAO
cell periphery 1 SLC1A1
cytoskeleton 1 SGCB
Secreted, extracellular space 1 DAO
brush border membrane 1 ACE
sperm midpiece 1 ACE
Recycling endosome membrane 1 SLC1A1
cell body 3 EPO, GLUL, SLC1A2
myelin sheath 1 BCL2
basal plasma membrane 1 ACE
Microsome 1 GLUL
secretory granule lumen 1 EPO
platelet alpha granule lumen 1 VEGFA
axon terminus 1 SLC1A1
specific granule lumen 1 DAO
postsynaptic density membrane 1 GRID1
apoptosome 1 CASP9
Vacuole 1 MST1
Synapse, synaptosome 1 SLC1A1
synaptic cleft 1 SLC1A1
apical dendrite 1 SLC1A1
death-inducing signaling complex 1 CASP3
dystrophin-associated glycoprotein complex 1 SGCB
sarcoglycan complex 1 SGCB
guanylate cyclase complex, soluble 1 GUCY1A1
astrocyte projection 1 SLC1A2
glial cell projection 2 GLUL, SLC1A1
asymmetric synapse 1 SLC1A1
neuron projection terminus 1 SLC1A2
BAD-BCL-2 complex 1 BCL2
distal dendrite 1 SLC1A1
proximal dendrite 1 SLC1A1
[Angiotensin-converting enzyme, soluble form]: Secreted 1 ACE
[Isoform Testis-specific]: Cell membrane 1 ACE
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
perisynaptic space 1 SLC1A1
membrane protein complex 1 SLC1A2
caspase complex 1 CASP9


文献列表

  • Franck Danel, Patrick Caspers, Claude Nuoffer, Michael Härtlein, Michael A Kron, Malcolm G P Page. Asparaginyl-tRNA synthetase pre-transfer editing assay. Current drug discovery technologies. 2011 Mar; 8(1):66-75. doi: 10.2174/157016311794519947. [PMID: 21091430]
  • Claudia Lanvers, Joao Paulo Vieira Pinheiro, Georg Hempel, Gudrun Wuerthwein, Joachim Boos. Analytical validation of a microplate reader-based method for the therapeutic drug monitoring of L-asparaginase in human serum. Analytical biochemistry. 2002 Oct; 309(1):117-26. doi: 10.1016/s0003-2697(02)00232-4. [PMID: 12381370]
  • C Thomsen, L Hansen, P D Suzdak. L-glutamate uptake inhibitors may stimulate phosphoinositide hydrolysis in baby hamster kidney cells expressing mGluR1a via heteroexchange with L-glutamate without direct activation of mGluR1a. Journal of neurochemistry. 1994 Dec; 63(6):2038-47. doi: 10.1046/j.1471-4159.1994.63062038.x. [PMID: 7964721]
  • S D Malley, J M Grange, F Hamedi-Sangsari, J R Vila. Synergistic anti-human immunodeficiency virus type 1 effect of hydroxamate compounds with 2',3'-dideoxyinosine in infected resting human lymphocytes. Proceedings of the National Academy of Sciences of the United States of America. 1994 Nov; 91(23):11017-21. doi: 10.1073/pnas.91.23.11017. [PMID: 7972000]
  • R Tournaire, S Malley, F Hamedi-Sangsari, N Thomasset, J Grange, J F Dore, J Vila. Therapeutic effects of D-aspartic acid beta-hydroxamate (DAH) on Friend erythroleukemia. International journal of cancer. 1994 Aug; 58(3):420-5. doi: 10.1002/ijc.2910580319. [PMID: 8050823]