Malonyl-CoA (BioDeep_00001868615)
Main id: BioDeep_00000001517
PANOMIX_OTCML-2023
代谢物信息卡片
Malonyl-CoA
化学式: C24H38N7O19P3S (853.1156)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC(C)(COP(=O)(O)OP(=O)(O)OCC1C(C(C(O1)N2C=NC3=C(N=CN=C32)N)O)OP(=O)(O)O)C(C(=O)NCCC(=O)NCCSC(=O)CC(=O)O)O
InChI: InChI=1S/C24H38N7O19P3S/c1-24(2,19(37)22(38)27-4-3-13(32)26-5-6-54-15(35)7-14(33)34)9-47-53(44,45)50-52(42,43)46-8-12-18(49-51(39,40)41)17(36)23(48-12)31-11-30-16-20(25)28-10-29-21(16)31/h10-12,17-19,23,36-37H,3-9H2,1-2H3,(H,26,32)(H,27,38)(H,33,34)(H,42,43)(H,44,45)(H2,25,28,29)(H2,39,40,41)/t12-,17-,18-,19+,23-/m1/s1
数据库引用编号
16 个数据库交叉引用编号
- ChEBI: CHEBI:15531
- KEGG: C00083
- PubChem: 644066
- DrugBank: DB04524
- ChEMBL: CHEMBL1234355
- MeSH: Malonyl Coenzyme A
- CAS: 524-14-1
- MetaboLights: MTBLC15531
- PubChem: 3383
- LipidMAPS: LMFA07050345
- KNApSAcK: C00007260
- PDB-CCD: MLC
- 3DMET: B04627
- NIKKAJI: J203.864A
- RefMet: Malonyl-CoA
- KNApSAcK: 15531
分类词条
相关代谢途径
Reactome(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
- 1906 - Streptomyces fradiae: 10.1007/S00253-004-1658-7
- 54571 - Streptomyces venezuelae: 10.1099/00221287-146-4-903
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Julia S Scott, Lake-Ee Quek, Andrew J Hoy, Johannes V Swinnen, Zeyad D Nassar, Lisa M Butler. Fatty acid elongation regulates mitochondrial β-oxidation and cell viability in prostate cancer by controlling malonyl-CoA levels.
Biochemical and biophysical research communications.
2024 Jan; 691(?):149273. doi:
10.1016/j.bbrc.2023.149273. [PMID: 38029544] - Lin Tan, Sara A Martinez, Philip L Lorenzi, Anja Karlstaedt. Quantitative Analysis of Acetyl-CoA, Malonyl-CoA, and Succinyl-CoA in Myocytes.
Journal of the American Society for Mass Spectrometry.
2023 Oct; ?(?):. doi:
10.1021/jasms.3c00278. [PMID: 37812744] - ". Malonyl-CoA links lipid metabolism to nutrient signalling by directly inhibiting mTORC1.
Nature cell biology.
2023 09; 25(9):1250-1251. doi:
10.1038/s41556-023-01206-9. [PMID: 37563254] - Jiwei Mao, Marta Tous Mohedano, Jing Fu, Xiaowei Li, Quanli Liu, Jens Nielsen, Verena Siewers, Yun Chen. Fine-tuning of p-coumaric acid synthesis to increase (2S)-naringenin production in yeast.
Metabolic engineering.
2023 Aug; 79(?):192-202. doi:
10.1016/j.ymben.2023.08.003. [PMID: 37611820] - Raffaele Nicastro, Laura Brohée, Josephine Alba, Julian Nüchel, Gianluca Figlia, Stefanie Kipschull, Peter Gollwitzer, Jesus Romero-Pozuelo, Stephanie A Fernandes, Andreas Lamprakis, Stefano Vanni, Aurelio A Teleman, Claudio De Virgilio, Constantinos Demetriades. Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor.
Nature cell biology.
2023 Aug; ?(?):. doi:
10.1038/s41556-023-01198-6. [PMID: 37563253] - Tamara Ivkovic, Snezana Tepavcevic, Snjezana Romic, Mojca Stojiljkovic, Milan Kostic, Jelena Stanisic, Goran Koricanac, Tijana Culafic. Cholecalciferol affects cardiac proteins regulating malonyl-CoA availability and intracellular calcium level.
General physiology and biophysics.
2023 May; 42(3):241-250. doi:
10.4149/gpb_2023005. [PMID: 37098736] - Tobias Schwanemann, Maike Otto, Benedikt Wynands, Jan Marienhagen, Nick Wierckx. A Pseudomonas taiwanensis malonyl-CoA platform strain for polyketide synthesis.
Metabolic engineering.
2023 Apr; 77(?):219-230. doi:
10.1016/j.ymben.2023.04.001. [PMID: 37031949] - Haoya Yao, Yaoqing Wang, Xiao Zhang, Ping Li, Lin Shang, Xiaocui Chen, Jia Zeng. Targeting peroxisomal fatty acid oxidation improves hepatic steatosis and insulin resistance in obese mice.
The Journal of biological chemistry.
2023 02; 299(2):102845. doi:
10.1016/j.jbc.2022.102845. [PMID: 36586435] - Juefeng Lu, Yuying Wang, Mingcheng Xu, Qiang Fei, Yang Gu, Yuanchan Luo, Hui Wu. Efficient biosynthesis of 3-hydroxypropionic acid from ethanol in metabolically engineered Escherichia coli.
Bioresource technology.
2022 Nov; 363(?):127907. doi:
10.1016/j.biortech.2022.127907. [PMID: 36087655] - Markus M Rinschen, Oleg Palygin, Ashraf El-Meanawy, Xavier Domingo-Almenara, Amelia Palermo, Lashodya V Dissanayake, Daria Golosova, Michael A Schafroth, Carlos Guijas, Fatih Demir, Johannes Jaegers, Megan L Gliozzi, Jingchuan Xue, Martin Hoehne, Thomas Benzing, Bernard P Kok, Enrique Saez, Markus Bleich, Nina Himmerkus, Ora A Weisz, Benjamin F Cravatt, Marcus Krüger, H Paul Benton, Gary Siuzdak, Alexander Staruschenko. Accelerated lysine metabolism conveys kidney protection in salt-sensitive hypertension.
Nature communications.
2022 07; 13(1):4099. doi:
10.1038/s41467-022-31670-0. [PMID: 35835746] - Nadine Godsman, Michael Kohlhaas, Alexander Nickel, Lesley Cheyne, Marco Mingarelli, Lutz Schweiger, Claire Hepburn, Chantal Munts, Andy Welch, Mirela Delibegovic, Marc Van Bilsen, Christoph Maack, Dana K Dawson. Metabolic alterations in a rat model of takotsubo syndrome.
Cardiovascular research.
2022 06; 118(8):1932-1946. doi:
10.1093/cvr/cvab081. [PMID: 33711093] - Sarah Snanoudj, Stéphanie Torre, Bénédicte Sudrié-Arnaud, Lenaig Abily-Donval, Alice Goldenberg, Gajja S Salomons, Stéphane Marret, Soumeya Bekri, Abdellah Tebani. Heterogenous Clinical Landscape in a Consanguineous Malonic Aciduria Family.
International journal of molecular sciences.
2021 Nov; 22(23):. doi:
10.3390/ijms222312633. [PMID: 34884438] - Satoshi Miyagaki, Ken Kikuchi, Jun Mori, Gary D Lopaschuk, Tomoko Iehara, Hajime Hosoi. Inhibition of lipid metabolism exerts antitumor effects on rhabdomyosarcoma.
Cancer medicine.
2021 09; 10(18):6442-6455. doi:
10.1002/cam4.4185. [PMID: 34472721] - Dongni Ji, Jianhua Li, Fanglin Xu, Yuhong Ren, Yong Wang. Improve the Biosynthesis of Baicalein and Scutellarein via Manufacturing Self-Assembly Enzyme Reactor In Vivo.
ACS synthetic biology.
2021 05; 10(5):1087-1094. doi:
10.1021/acssynbio.0c00606. [PMID: 33880917] - Jixing Xia, Zhaojiang Guo, Zezhong Yang, Haolin Han, Shaoli Wang, Haifeng Xu, Xin Yang, Fengshan Yang, Qingjun Wu, Wen Xie, Xuguo Zhou, Wannes Dermauw, Ted C J Turlings, Youjun Zhang. Whitefly hijacks a plant detoxification gene that neutralizes plant toxins.
Cell.
2021 04; 184(7):1693-1705.e17. doi:
10.1016/j.cell.2021.02.014. [PMID: 33770502] - Muhammad Zulfiqar Ahmad, Yanrui Zhang, Xiangsheng Zeng, Penghui Li, Xiaobo Wang, Vagner A Benedito, Jian Zhao. Isoflavone malonyl-CoA acyltransferase GmMaT2 is involved in nodulation of soybean by modifying synthesis and secretion of isoflavones.
Journal of experimental botany.
2021 02; 72(4):1349-1369. doi:
10.1093/jxb/eraa511. [PMID: 33130852] - Rut Fadó, Rosalía Rodríguez-Rodríguez, Núria Casals. The return of malonyl-CoA to the brain: Cognition and other stories.
Progress in lipid research.
2021 01; 81(?):101071. doi:
10.1016/j.plipres.2020.101071. [PMID: 33186641] - Meaghan A Valliere, Tyler P Korman, Mark A Arbing, James U Bowie. A bio-inspired cell-free system for cannabinoid production from inexpensive inputs.
Nature chemical biology.
2020 12; 16(12):1427-1433. doi:
10.1038/s41589-020-0631-9. [PMID: 32839605] - Maria Casas, Rut Fadó, José Luis Domínguez, Aina Roig, Moena Kaku, Shigeru Chohnan, Montse Solé, Mercedes Unzeta, Alfredo Jesús Miñano-Molina, José Rodríguez-Álvarez, Eamonn James Dickson, Núria Casals. Sensing of nutrients by CPT1C controls SAC1 activity to regulate AMPA receptor trafficking.
The Journal of cell biology.
2020 10; 219(10):. doi:
10.1083/jcb.201912045. [PMID: 32931550] - Xin'e Shi, Xiaomin Zhou, Jie Wang, Deming Zhang, Kuilong Huang, Xiao Li, Gongshe Yang. Tartronic acid promotes de novo lipogenesis and inhibits CPT-1β by upregulating acetyl-CoA and malonyl-CoA.
Life sciences.
2020 Oct; 258(?):118240. doi:
10.1016/j.lfs.2020.118240. [PMID: 32781072] - Jingbo Ma, Yang Gu, Monireh Marsafari, Peng Xu. Synthetic biology, systems biology, and metabolic engineering of Yarrowia lipolytica toward a sustainable biorefinery platform.
Journal of industrial microbiology & biotechnology.
2020 Oct; 47(9-10):845-862. doi:
10.1007/s10295-020-02290-8. [PMID: 32623653] - Sonja Giger, Larisa V Kovtonyuk, Sebastian G Utz, Mergim Ramosaj, Werner J Kovacs, Emanuel Schmid, Vassilios Ioannidis, Melanie Greter, Markus G Manz, Matthias P Lutolf, Sebastian Jessberger, Marlen Knobloch. A Single Metabolite which Modulates Lipid Metabolism Alters Hematopoietic Stem/Progenitor Cell Behavior and Promotes Lymphoid Reconstitution.
Stem cell reports.
2020 09; 15(3):566-576. doi:
10.1016/j.stemcr.2020.07.021. [PMID: 32857979] - Seung Hoon Lee, Jung Min Ko, Mi-Kyoung Song, Junghan Song, Kyung Sun Park. A Korean child diagnosed with malonic aciduria harboring a novel start codon mutation following presentation with dilated cardiomyopathy.
Molecular genetics & genomic medicine.
2020 09; 8(9):e1379. doi:
10.1002/mgg3.1379. [PMID: 32602666] - Eiichiro Kan, Yohei Katsuyama, Jun-Ichi Maruyama, Koichi Tamano, Yasuji Koyama, Yasuo Ohnishi. Efficient heterologous production of atrochrysone carboxylic acid-related polyketides in an Aspergillus oryzae host with enhanced malonyl-coenzyme A supply.
The Journal of general and applied microbiology.
2020 Aug; 66(3):195-199. doi:
10.2323/jgam.2019.07.001. [PMID: 31776294] - Todd A Starich, Xiaofei Bai, David Greenstein. Gap junctions deliver malonyl-CoA from soma to germline to support embryogenesis in Caenorhabditis elegans.
eLife.
2020 07; 9(?):. doi:
10.7554/elife.58619. [PMID: 32735213] - Xiaocui Chen, Lin Shang, Senwen Deng, Ping Li, Kai Chen, Ting Gao, Xiao Zhang, Zhilan Chen, Jia Zeng. Peroxisomal oxidation of erucic acid suppresses mitochondrial fatty acid oxidation by stimulating malonyl-CoA formation in the rat liver.
The Journal of biological chemistry.
2020 07; 295(30):10168-10179. doi:
10.1074/jbc.ra120.013583. [PMID: 32493774] - Johann E Kufs, Sandra Hoefgen, Julia Rautschek, Alexander U Bissell, Carola Graf, Jonas Fiedler, Daniel Braga, Lars Regestein, Miriam A Rosenbaum, Julian Thiele, Vito Valiante. Rational Design of Flavonoid Production Routes Using Combinatorial and Precursor-Directed Biosynthesis.
ACS synthetic biology.
2020 07; 9(7):1823-1832. doi:
10.1021/acssynbio.0c00172. [PMID: 32525654] - Shuo-Fu Yuan, Xiunan Yi, Trevor G Johnston, Hal S Alper. De novo resveratrol production through modular engineering of an Escherichia coli-Saccharomyces cerevisiae co-culture.
Microbial cell factories.
2020 Jul; 19(1):143. doi:
10.1186/s12934-020-01401-5. [PMID: 32664999] - Shengfang Zhou, Suman Lama, Jihong Jiang, Mugesh Sankaranarayanan, Sunghoon Park. Use of acetate for the production of 3-hydroxypropionic acid by metabolically-engineered Pseudomonas denitrificans.
Bioresource technology.
2020 Jul; 307(?):123194. doi:
10.1016/j.biortech.2020.123194. [PMID: 32234590] - Robert W McGarrah, Guo-Fang Zhang, Bridgette A Christopher, Yann Deleye, Jacquelyn M Walejko, Stephani Page, Olga Ilkayeva, Phillip J White, Christopher B Newgard. Dietary branched-chain amino acid restriction alters fuel selection and reduces triglyceride stores in hearts of Zucker fatty rats.
American journal of physiology. Endocrinology and metabolism.
2020 02; 318(2):E216-E223. doi:
10.1152/ajpendo.00334.2019. [PMID: 31794262] - Leonardo Perez de Souza, Karolina Garbowicz, Yariv Brotman, Takayuki Tohge, Alisdair R Fernie. The Acetate Pathway Supports Flavonoid and Lipid Biosynthesis in Arabidopsis.
Plant physiology.
2020 02; 182(2):857-869. doi:
10.1104/pp.19.00683. [PMID: 31719153] - Marc Prentki, Barbara E Corkey, S R Murthy Madiraju. Lipid-associated metabolic signalling networks in pancreatic beta cell function.
Diabetologia.
2020 01; 63(1):10-20. doi:
10.1007/s00125-019-04976-w. [PMID: 31423551] - Getachew Debas Belew, Joao Silva, Joao Rito, Ludgero Tavares, Ivan Viegas, Jose Teixeira, Paulo J Oliveira, Maria Paula Macedo, John G Jones. Transfer of glucose hydrogens via acetyl-CoA, malonyl-CoA, and NADPH to fatty acids during de novo lipogenesis.
Journal of lipid research.
2019 12; 60(12):2050-2056. doi:
10.1194/jlr.ra119000354. [PMID: 31575642] - Yongkun Lv, Monireh Marsafari, Mattheos Koffas, Jingwen Zhou, Peng Xu. Optimizing Oleaginous Yeast Cell Factories for Flavonoids and Hydroxylated Flavonoids Biosynthesis.
ACS synthetic biology.
2019 11; 8(11):2514-2523. doi:
10.1021/acssynbio.9b00193. [PMID: 31622552] - Jian-Ping Huang, Chengli Fang, Xiaoyan Ma, Li Wang, Jing Yang, Jianying Luo, Yijun Yan, Yu Zhang, Sheng-Xiong Huang. Tropane alkaloids biosynthesis involves an unusual type III polyketide synthase and non-enzymatic condensation.
Nature communications.
2019 09; 10(1):4036. doi:
10.1038/s41467-019-11987-z. [PMID: 31492848] - Nitish Boodhoo, Nitin Kamble, Benedikt B Kaufer, Shahriar Behboudi. Replication of Marek's Disease Virus Is Dependent on Synthesis of De Novo Fatty Acid and Prostaglandin E2.
Journal of virology.
2019 07; 93(13):. doi:
10.1128/jvi.00352-19. [PMID: 30971474] - Eiichiro Kan, Yohei Katsuyama, Jun-Ichi Maruyama, Koichi Tamano, Yasuji Koyama, Yasuo Ohnishi. Production of the plant polyketide curcumin in Aspergillus oryzae: strengthening malonyl-CoA supply for yield improvement.
Bioscience, biotechnology, and biochemistry.
2019 Jul; 83(7):1372-1381. doi:
10.1080/09168451.2019.1606699. [PMID: 31023165] - Lars Milke, Patrícia Ferreira, Nicolai Kallscheuer, Adelaide Braga, Michael Vogt, Jannick Kappelmann, Joana Oliveira, Ana Rita Silva, Isabel Rocha, Michael Bott, Stephan Noack, Nuno Faria, Jan Marienhagen. Modulation of the central carbon metabolism of Corynebacterium glutamicum improves malonyl-CoA availability and increases plant polyphenol synthesis.
Biotechnology and bioengineering.
2019 06; 116(6):1380-1391. doi:
10.1002/bit.26939. [PMID: 30684355] - William P Esler, Gregory J Tesz, Marc K Hellerstein, Carine Beysen, Raja Sivamani, Scott M Turner, Steven M Watkins, Paul A Amor, Santos Carvajal-Gonzalez, Frank J Geoly, Kathleen E Biddle, Julie J Purkal, Mark Fitch, Clare Buckeridge, Annette M Silvia, David A Griffith, Matthew Gorgoglione, Lauren Hassoun, Suzana S Bosanac, Nicholas B Vera, Timothy P Rolph, Jeffrey A Pfefferkorn, Gabriele E Sonnenberg. Human sebum requires de novo lipogenesis, which is increased in acne vulgaris and suppressed by acetyl-CoA carboxylase inhibition.
Science translational medicine.
2019 05; 11(492):. doi:
10.1126/scitranslmed.aau8465. [PMID: 31092695] - Lars Milke, Nicolai Kallscheuer, Jannick Kappelmann, Jan Marienhagen. Tailoring Corynebacterium glutamicum towards increased malonyl-CoA availability for efficient synthesis of the plant pentaketide noreugenin.
Microbial cell factories.
2019 Apr; 18(1):71. doi:
10.1186/s12934-019-1117-x. [PMID: 30975146] - Leila Motlagh Scholle, Diana Lehmann, Pushpa Raj Joshi, Stephan Zierz. Normal FGF-21-Serum Levels in Patients with Carnitine Palmitoyltransferase II (CPT II) Deficiency.
International journal of molecular sciences.
2019 Mar; 20(6):. doi:
10.3390/ijms20061400. [PMID: 30897730] - Jianhua Li, Chenfei Tian, Yuhui Xia, Ishmael Mutanda, Kaibo Wang, Yong Wang. Production of plant-specific flavones baicalein and scutellarein in an engineered E. coli from available phenylalanine and tyrosine.
Metabolic engineering.
2019 03; 52(?):124-133. doi:
10.1016/j.ymben.2018.11.008. [PMID: 30496827] - Ah-Reum Lee, Moonhyuk Kwon, Min-Kyoung Kang, Jeonghan Kim, Soo-Un Kim, Dae-Kyun Ro. Increased sesqui- and triterpene production by co-expression of HMG-CoA reductase and biotin carboxyl carrier protein in tobacco (Nicotiana benthamiana).
Metabolic engineering.
2019 03; 52(?):20-28. doi:
10.1016/j.ymben.2018.10.008. [PMID: 30389612] - Jinjin Diao, Xinyu Song, Jinyu Cui, Liangsen Liu, Mengliang Shi, Fangzhong Wang, Weiwen Zhang. Rewiring metabolic network by chemical modulator based laboratory evolution doubles lipid production in Crypthecodinium cohnii.
Metabolic engineering.
2019 01; 51(?):88-98. doi:
10.1016/j.ymben.2018.10.004. [PMID: 30393203] - Ying Zhao, Bi-Han Wu, Zhen-Ning Liu, Jianjun Qiao, Guang-Rong Zhao. Combinatorial Optimization of Resveratrol Production in Engineered E. coli.
Journal of agricultural and food chemistry.
2018 Dec; 66(51):13444-13453. doi:
10.1021/acs.jafc.8b05014. [PMID: 30488696] - Ulrike Bruning, Francisco Morales-Rodriguez, Joanna Kalucka, Jermaine Goveia, Federico Taverna, Karla C S Queiroz, Charlotte Dubois, Anna Rita Cantelmo, Rongyuan Chen, Stefan Loroch, Evy Timmerman, Vanessa Caixeta, Katarzyna Bloch, Lena-Christin Conradi, Lucas Treps, An Staes, Kris Gevaert, Andrew Tee, Mieke Dewerchin, Clay F Semenkovich, Francis Impens, Birgit Schilling, Eric Verdin, Johannes V Swinnen, Jordan L Meier, Rhushikesh A Kulkarni, Albert Sickmann, Bart Ghesquière, Luc Schoonjans, Xuri Li, Massimiliano Mazzone, Peter Carmeliet. Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves mTOR Malonylation.
Cell metabolism.
2018 12; 28(6):866-880.e15. doi:
10.1016/j.cmet.2018.07.019. [PMID: 30146486] - A Braga, P Ferreira, J Oliveira, I Rocha, N Faria. Heterologous production of resveratrol in bacterial hosts: current status and perspectives.
World journal of microbiology & biotechnology.
2018 Jul; 34(8):122. doi:
10.1007/s11274-018-2506-8. [PMID: 30054757] - Mei-Yu Sun, Jing-Yi Li, Dong Li, Feng-Jie Huang, Di Wang, Hui Li, Quan Xing, Hui-Bin Zhu, Lei Shi. Full-Length Transcriptome Sequencing and Modular Organization Analysis of the Naringin/Neoeriocitrin-Related Gene Expression Pattern in Drynaria roosii.
Plant & cell physiology.
2018 Jul; 59(7):1398-1414. doi:
10.1093/pcp/pcy072. [PMID: 29660070] - Shamir Cassim, Valérie-Ann Raymond, Layla Dehbidi-Assadzadeh, Pascal Lapierre, Marc Bilodeau. Metabolic reprogramming enables hepatocarcinoma cells to efficiently adapt and survive to a nutrient-restricted microenvironment.
Cell cycle (Georgetown, Tex.).
2018; 17(7):903-916. doi:
10.1080/15384101.2018.1460023. [PMID: 29633904] - Heng Li, Wei Chen, Ruinan Jin, Jian-Ming Jin, Shuang-Yan Tang. Biosensor-aided high-throughput screening of hyper-producing cells for malonyl-CoA-derived products.
Microbial cell factories.
2017 Nov; 16(1):187. doi:
10.1186/s12934-017-0794-6. [PMID: 29096626] - J Andrew Jones, Victoria R Vernacchio, Shannon M Collins, Abhijit N Shirke, Yu Xiu, Jacob A Englaender, Brady F Cress, Catherine C McCutcheon, Robert J Linhardt, Richard A Gross, Mattheos A G Koffas. Complete Biosynthesis of Anthocyanins Using E. coli Polycultures.
mBio.
2017 06; 8(3):. doi:
10.1128/mbio.00621-17. [PMID: 28588129] - Yves Mugabo, Shangang Zhao, Julien Lamontagne, Anfal Al-Mass, Marie-Line Peyot, Barbara E Corkey, Erik Joly, S R Murthy Madiraju, Marc Prentki. Metabolic fate of glucose and candidate signaling and excess-fuel detoxification pathways in pancreatic β-cells.
The Journal of biological chemistry.
2017 05; 292(18):7407-7422. doi:
10.1074/jbc.m116.763060. [PMID: 28280244] - Junjun Wu, Xia Zhang, Yingjie Zhu, Qinyu Tan, Jiacheng He, Mingsheng Dong. Rational modular design of metabolic network for efficient production of plant polyphenol pinosylvin.
Scientific reports.
2017 05; 7(1):1459. doi:
10.1038/s41598-017-01700-9. [PMID: 28469159] - Chandra Shekar R Ambati, Furong Yuan, Lutfi A Abu-Elheiga, Yiqing Zhang, Vivekananda Shetty. Identification and Quantitation of Malonic Acid Biomarkers of In-Born Error Metabolism by Targeted Metabolomics.
Journal of the American Society for Mass Spectrometry.
2017 05; 28(5):929-938. doi:
10.1007/s13361-017-1631-1. [PMID: 28315235] - Jenny Lindberg Yilmaz, Ze Long Lim, Mirela Beganovic, Steven Breazeale, Carl Andre, Sten Stymne, Patricia Vrinten, Toralf Senger. Determination of Substrate Preferences for Desaturases and Elongases for Production of Docosahexaenoic Acid from Oleic Acid in Engineered Canola.
Lipids.
2017 03; 52(3):207-222. doi:
10.1007/s11745-017-4235-4. [PMID: 28197856] - Paula M Miotto, Gregory R Steinberg, Graham P Holloway. Controlling skeletal muscle CPT-I malonyl-CoA sensitivity: the importance of AMPK-independent regulation of intermediate filaments during exercise.
The Biochemical journal.
2017 02; 474(4):557-569. doi:
10.1042/bcj20160913. [PMID: 27941154] - Diana Lehmann, Leila Motlagh, Dina Robaa, Stephan Zierz. Muscle Carnitine Palmitoyltransferase II Deficiency: A Review of Enzymatic Controversy and Clinical Features.
International journal of molecular sciences.
2017 Jan; 18(1):. doi:
10.3390/ijms18010082. [PMID: 28054946] - Mingji Li, Konstantin Schneider, Mette Kristensen, Irina Borodina, Jens Nielsen. Engineering yeast for high-level production of stilbenoid antioxidants.
Scientific reports.
2016 11; 6(?):36827. doi:
10.1038/srep36827. [PMID: 27833117] - L Meng, Z Xiong, J Chu, Y Wang. Enhanced production of avermectin by deletion of type III polyketide synthases biosynthetic cluster rpp in Streptomyces avermitilis.
Letters in applied microbiology.
2016 Nov; 63(5):384-390. doi:
10.1111/lam.12635. [PMID: 27538855] - Junjun Wu, Xia Zhang, Jingwen Zhou, Mingsheng Dong. Efficient biosynthesis of (2S)-pinocembrin from d-glucose by integrating engineering central metabolic pathways with a pH-shift control strategy.
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