Mometasone (BioDeep_00001868408)
Main id: BioDeep_00000006608
代谢物信息卡片
Mometasone
化学式: C22H28Cl2O4 (426.1364548)
中文名称:
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CCl)O)C)O)Cl)C
InChI: InChI=1S/C22H28Cl2O4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-17,26,28H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
描述信息
D - Dermatologicals > D07 - Corticosteroids, dermatological preparations > D07X - Corticosteroids, other combinations > D07XC - Corticosteroids, potent, other combinations
R - Respiratory system > R03 - Drugs for obstructive airway diseases > R03B - Other drugs for obstructive airway diseases, inhalants > R03BA - Glucocorticoids
D - Dermatologicals > D07 - Corticosteroids, dermatological preparations > D07A - Corticosteroids, plain > D07AC - Corticosteroids, potent (group iii)
R - Respiratory system > R01 - Nasal preparations > R01A - Decongestants and other nasal preparations for topical use > R01AD - Corticosteroids
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C308 - Immunotherapeutic Agent > C574 - Immunosuppressant > C211 - Therapeutic Corticosteroid
D000893 - Anti-Inflammatory Agents
D018926 - Anti-Allergic Agents
D003879 - Dermatologic Agents
同义名列表
2 个代谢物同义名
数据库引用编号
12 个数据库交叉引用编号
- ChEBI: CHEBI:6970
- KEGG: C07816
- KEGGdrug: D08227
- PubChem: 441335
- DrugBank: DB00764
- ChEMBL: CHEMBL1201404
- MeSH: Mometasone Furoate
- PubChem: 10018
- CAS: 105102-22-5
- NIKKAJI: J536.076E
- RefMet: Mometasone
- KNApSAcK: 6970
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Priscila L Zimath, Milena S Almeida, Maciel A Bruxel, Alex Rafacho. Oral mometasone furoate administration preserves anti-inflammatory action with fewer metabolic adverse effects in rats.
Biochemical pharmacology.
2023 04; 210(?):115486. doi:
10.1016/j.bcp.2023.115486. [PMID: 36893817] - Mehdi Pasalar, Bahareh Ahadi, Hamid Reza Mirzaei, Judith Buentzel, Mojgan Mehri Ardestani, Shaghayegh Kamian, Ghazaleh Heydarirad. Comparing Dermolina-Henna Cream with Mometasone Cream in Improving Radiodermatitis Among Patients with Breast Cancer: A Randomized Active-Control Double-Blind Clinical Trial.
Journal of integrative and complementary medicine.
2022 Nov; 28(11):895-903. doi:
10.1089/jicm.2022.0551. [PMID: 36103288] - Yavuz Atar, Semih Karaketir, Imran Aydogdu, Hüseyin Sari, Hasan Sami Bircan, Yavuz Uyar, Enis Ekincioglu, Seyma Görcin Karaketir, Enes Atac, Güler Berkiten. Comparison of Isotonic Seawater Nasal Spray Containing Chamomile Liquid Extract and Other Isotonic Seawater Nasal Washing Solutions for Allergic Rhinitis.
The Annals of otology, rhinology, and laryngology.
2022 Apr; 131(4):427-434. doi:
10.1177/00034894211025411. [PMID: 34142567] - Hannah J Brown, Pete S Batra, Michael Eggerstedt, Ashwin Ganti, Peter Papagiannopoulos, Bobby A Tajudeen. The possibility of short-term hypothalamic-pituitary-adrenal axis suppression with high-volume, high-dose nasal mometasone irrigation in postsurgical patients with chronic rhinosinusitis.
International forum of allergy & rhinology.
2022 03; 12(3):249-256. doi:
10.1002/alr.22894. [PMID: 34569177] - Changcheng You, Ling-Fang Tseng, Alexander Pappas, Danny Concagh, Yina Kuang. Drug Release and Pharmacokinetic Evaluation of Novel Implantable Mometasone Furoate Matrices in Rabbit Maxillary Sinuses.
American journal of rhinology & allergy.
2022 Mar; 36(2):198-206. doi:
10.1177/19458924211039197. [PMID: 34463546] - Hong Sun, Wei Zhang, Guibo Wang, Chuanwei Sun, Yan Liang, Aijun Li, Qingfeng Li, Jie Lei. Treatment Effect of Mometasone Furoate Cream on Lichen Sclerosus et Atrophicus of External Genitalia in Boys and Its Correlation with Toll-Like Receptor 4 and Myeloid Differentiation Factor 88.
Journal of healthcare engineering.
2022; 2022(?):3495099. doi:
10.1155/2022/3495099. [PMID: 35399843] - Dorothee Dähnhardt, Mike Bastian, Stephan Dähnhardt-Pfeiffer, Matthias Buchner, Regina Fölster-Holst. Comparing the effects of proactive treatment with tacrolimus ointment and mometasone furoate on the epidermal barrier structure and ceramide levels of patients with atopic dermatitis.
The Journal of dermatological treatment.
2021 Nov; 32(7):721-729. doi:
10.1080/09546634.2019.1708240. [PMID: 31865821] - Hossein Kasiri, Nima Rouhani, Ebrahim Salehifar, Monireh Ghazaeian, Sahar Fallah. Mometasone furoate nasal spray in the treatment of patients with COVID-19 olfactory dysfunction: A randomized, double blind clinical trial.
International immunopharmacology.
2021 Sep; 98(?):107871. doi:
10.1016/j.intimp.2021.107871. [PMID: 34147912] - Katie E Webster, Lisa O'Byrne, Samuel MacKeith, Carl Philpott, Claire Hopkins, Martin J Burton. Interventions for the prevention of persistent post-COVID-19 olfactory dysfunction.
The Cochrane database of systematic reviews.
2021 07; 7(?):CD013877. doi:
10.1002/14651858.cd013877.pub2. [PMID: 34291812] - Christian Bartels, Monish Jain, Jing Yu, Hanns-Christian Tillmann, Soniya Vaidya. Population Pharmacokinetic Analysis of Indacaterol/Glycopyrronium/Mometasone Furoate After Administration of Combination Therapies Using the Breezhaler® Device in Patients with Asthma.
European journal of drug metabolism and pharmacokinetics.
2021 Jul; 46(4):487-504. doi:
10.1007/s13318-021-00689-x. [PMID: 34024035] - Abdelrahman Ahmed Abdelalim, Ayman Abdelaal Mohamady, Rasha Abdelhamid Elsayed, Mona Ahmed Elawady, Abdelhakim Fouad Ghallab. Corticosteroid nasal spray for recovery of smell sensation in COVID-19 patients: A randomized controlled trial.
American journal of otolaryngology.
2021 Mar; 42(2):102884. doi:
10.1016/j.amjoto.2020.102884. [PMID: 33429174] - Daisuke Miyazawa, Gen Kaneko. Clinical trials of inhaled beclomethasone and mometasone for COVID-19 should be conducted.
Journal of medical virology.
2021 02; 93(2):637-638. doi:
10.1002/jmv.26413. [PMID: 32776550] - Soniya Vaidya, Juergen Jauernig, Brian Ethell, Nasri Abdallah, Surendra Machineni, Anton Drollmann, Olivier Heudi, Stefanie Last, Michael Hahn, Rajkumar Radhakrishnan, Stanislav Ignatenko, Hanns-Christian Tillmann. Pharmacokinetics of indacaterol, glycopyrronium and mometasone furoate following once-daily inhalation as a combination in healthy subjects.
Pulmonary pharmacology & therapeutics.
2020 10; 64(?):101964. doi:
10.1016/j.pupt.2020.101964. [PMID: 33035700] - Sushma Bhattachan, Yogesh Neupane, Bibhu Pradhan, Naramaya Thapa. Comparison of Outcomes Between Mometasone Furoate Intranasal Spray and Oral Montelukast in Patients with Allergic Rhinitis.
Journal of Nepal Health Research Council.
2020 Sep; 18(2):268-270. doi:
10.33314/jnhrc.v18i2.2509. [PMID: 32969391] - Auddie M Sweis, Tran B Locke, Jennifer E Douglas, Theodore C Lin, Brian M Sweis, Alyssa M Civantos, David W Kennedy. Management of chronic rhinosinusitis with steroid nasal irrigations: A viable nonsurgical alternative in the COVID-19 era.
International forum of allergy & rhinology.
2020 09; 10(9):1108-1109. doi:
10.1002/alr.22646. [PMID: 32573106] - Giuseppe Ruggiero, Fabio Arcangeli, Torello Lotti. Therapy for probable COVID-19 associated erythema pernio-like lesions in pediatric age. Case report.
Dermatologic therapy.
2020 Jul; 33(4):e13616. doi:
10.1111/dth.13616. [PMID: 32424851] - Mohamed Tarek, Hebatallah A Wagdy, Eman S Elzanfaly, Sawsan M Amer. A Validated Ultra-Performance Liquid Chromatographic Method for the Simultaneous Determination of Nadifloxacin, Mometasone Furoate and Miconazole Nitrate in Their Combined Dosage Form and Spiked Human Plasma Samples.
Journal of chromatographic science.
2020 Jan; 57(10):867-873. doi:
10.1093/chromsci/bmz082. [PMID: 31602483] - Richard G Douglas, Alkis J Psaltis, Joanne Rimmer, Tom Kuruvilla, Anders Cervin, Yina Kuang. Phase 1 clinical study to assess the safety of a novel drug delivery system providing long-term topical steroid therapy for chronic rhinosinusitis.
International forum of allergy & rhinology.
2019 04; 9(4):378-387. doi:
10.1002/alr.22288. [PMID: 30645028] - Arielle L Langer, Andrew Leader, Seunghee Kim-Schulze, Yelena Ginzburg, Miriam Merad, Jeffrey Glassberg. Inhaled steroids associated with decreased macrophage markers in nonasthmatic individuals with sickle cell disease in a randomized trial.
Annals of hematology.
2019 Apr; 98(4):841-849. doi:
10.1007/s00277-019-03635-9. [PMID: 30783732] - Piyush Patel, Anne Marie Salapatek, Ravi S Talluri, Sudeesh K Tantry. Pharmacokinetics of intranasal olopatadine in the fixed-dose combination GSP301 versus two monotherapy intranasal olopatadine formulations.
Allergy and asthma proceedings.
2018 May; 39(3):224-231. doi:
10.2500/aap.2018.39.4133. [PMID: 29669667] - Piyush Patel, Anne Marie Salapatek, Ravi S Talluri, Sudeesh K Tantry. Pharmacokinetics of intranasal mometasone in the fixed-dose combination GSP301 versus two monotherapy intranasal mometasone formulations.
Allergy and asthma proceedings.
2018 May; 39(3):232-239. doi:
10.2500/aap.2018.39.4134. [PMID: 29669668] - Ebru Altuntaş, Gülgün Yener, Remzi Doğan, Fadlullah Aksoy, Mehmet Şerif Aydın, Ersin Karataş. Effects of a Thermosensitive In Situ Gel Containing Mometasone Furoate on a Rat Allergic Rhinitis Model.
American journal of rhinology & allergy.
2018 May; 32(3):132-138. doi:
10.1177/1945892418764951. [PMID: 29644886] - Navjot Kaur, Kusha Sharma, Neena Bedi. Topical Nanostructured Lipid Carrier Based Hydrogel of Mometasone Furoate for the Treatment of Psoriasis.
Pharmaceutical nanotechnology.
2018; 6(2):133-143. doi:
10.2174/2211738506666180523112513. [PMID: 29788899] - Y Qiao, T Liu, K J Zhang, Y Feng, Y Liu, K T Li. [Allergic rhinitis management:environment control and patient education].
Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery.
2017 Sep; 31(17):1315-1321. doi:
10.13201/j.issn.1001-1781.2017.17.005. [PMID: 29798221] - Anne E Dixon, Mario Castro, Lynn B Gerald, Janet T Holbrook, Robert J Henderson, Thomas B Casale, Charles G Irvin, Kendall Black, Robert A Wise, Elizabeth A Sugar. Effect of intranasal corticosteroids on allergic airway disease in asthma.
The journal of allergy and clinical immunology. In practice.
2017 Jul; 5(4):1125-1128.e3. doi:
10.1016/j.jaip.2017.02.022. [PMID: 28396113] - Aditya K Gupta, Sarah G Versteeg. Topical Treatment of Facial Seborrheic Dermatitis: A Systematic Review.
American journal of clinical dermatology.
2017 Apr; 18(2):193-213. doi:
10.1007/s40257-016-0232-2. [PMID: 27804089] - Randall Ow, Eli Groppo, Donald Clutter, Anna K Gawlicka. Steroid-eluting sinus implant for in-office treatment of recurrent polyposis: a pharmacokinetic study.
International forum of allergy & rhinology.
2014 Oct; 4(10):816-22. doi:
10.1002/alr.21414. [PMID: 25256638] - Ana Melero, Aline Ferreira Ourique, Silvia Stanisçuaski Guterres, Adriana Raffin Pohlmann, Claus-Michael Lehr, Ruy Carlos Ruver Beck, Ulrich Schaefer. Nanoencapsulation in lipid-core nanocapsules controls mometasone furoate skin permeability rate and its penetration to the deeper skin layers.
Skin pharmacology and physiology.
2014; 27(4):217. doi:
10.1159/000354921. [PMID: 24751514] - Teddy Kosoglou, James Hubbell, David L Cutler, Amy O Johnson-Levonas, Danlin Xu, Bhavna S Kantesaria, Kenneth Kim, S David Miller. Hypothalamic-pituitary-adrenal axis effects of mometasone furoate/formoterol fumarate vs fluticasone propionate/salmeterol administered through metered-dose inhaler.
Chest.
2013 Dec; 144(6):1795-1802. doi:
10.1378/chest.13-0505. [PMID: 24077095] - Yuanyuan Li, Lin-Feng Li. Topical application of a Chinese medicine, Qingpeng ointment, ameliorates 2, 4-dinitrofluorobenzene-induced allergic contact dermatitis in BALB/c mice.
European journal of dermatology : EJD.
2013 Nov; 23(6):803-6. doi:
10.1684/ejd.2013.2185. [PMID: 24192330] - Stephan Dähnhardt-Pfeiffer, Dorothee Dähnhardt, Matthias Buchner, Kersten Walter, Ehrhardt Proksch, Regina Fölster-Holst. Comparison of effects of tacrolimus ointment and mometasone furoate cream on the epidermal barrier of patients with atopic dermatitis.
Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG.
2013 May; 11(5):437-43. doi:
10.1111/ddg.12074. [PMID: 23551950] - Christian Grabow Westergaard, Celeste Porsbjerg, Vibeke Backer. A review of mometasone furoate / formoterol in the treatment of asthma.
Expert opinion on pharmacotherapy.
2013 Feb; 14(3):339-46. doi:
10.1517/14656566.2013.761976. [PMID: 23363416] - Teddy Kosoglou, James Hubbell, Fengjuan Xuan, David L Cutler, Alan G Meehan, Bhavna Kantesaria, Bret A Wittmer. Comparison of the systemic bioavailability of mometasone furoate after oral inhalation from a mometasone furoate/formoterol fumarate metered-dose inhaler versus a mometasone furoate dry-powder inhaler in patients with chronic obstructive pulmonary disease.
International journal of chronic obstructive pulmonary disease.
2013; 8(?):107-16. doi:
10.2147/copd.s36592. [PMID: 23525511] - Seiichiro Makihara, Mitsuhiro Okano, Tazuko Fujiwara, Masayo Kimura, Takaya Higaki, Takenori Haruna, Yohei Noda, Kengo Kanai, Shin Kariya, Kazunori Nishizaki. Early interventional treatment with intranasal mometasone furoate in Japanese cedar/cypress pollinosis: a randomized placebo-controlled trial.
Allergology international : official journal of the Japanese Society of Allergology.
2012 Jun; 61(2):295-304. doi:
10.2332/allergolint.11-oa-0382. [PMID: 22441634] - Keivan Gohari Moghaddam, Negin Rashidi, Hamidreza Aghaei Meybodi, Nader Rezaie, Mahdi Montazeri, Ramin Heshmat, Zohreh Annabestani. The effect of inhaled corticosteroids on hypothalamic-pituitary-adrenal axis.
Indian journal of pharmacology.
2012 May; 44(3):314-8. doi:
10.4103/0253-7613.96300. [PMID: 22701238] - Danielle Morello Park, Teresa Lúcia Lamano Carvalho, Janete Aparecida Anselmo Franci, Wilma Terezinha Anselmo-Lima. Influence of treatment with intranasal corticosteroids on the nasal mucosa, weight, and corticosteroid concentration in rats.
American journal of rhinology & allergy.
2012 Jan; 26(1):e46-9. doi:
10.2500/ajra.2012.26.3702. [PMID: 22182666] - David P Skoner, Eli O Meltzer, Henry Milgrom, Paul Stryszak, Ariel Teper, Heribert Staudinger. Effects of inhaled mometasone furoate on growth velocity and adrenal function: a placebo-controlled trial in children 4-9 years old with mild persistent asthma.
The Journal of asthma : official journal of the Association for the Care of Asthma.
2011 Oct; 48(8):848-59. doi:
10.3109/02770903.2011.604883. [PMID: 21854342] - M Sagit, H Erdamar, C Saka, S Yalcin, I Akin. Effect of antioxidants on the clinical outcome of patients with nasal polyposis.
The Journal of laryngology and otology.
2011 Aug; 125(8):811-5. doi:
10.1017/s0022215111001149. [PMID: 21669016] - Joaquim Mullol, Francisco de Borja Callejas, Maria Asunción Martínez-Antón, Eva Méndez-Arancibia, Isam Alobid, Laura Pujols, Antonio Valero, Cesar Picado, Jordi Roca-Ferrer. Mometasone and desloratadine additive effect on eosinophil survival and cytokine secretion from epithelial cells.
Respiratory research.
2011 Feb; 12(?):23. doi:
10.1186/1465-9921-12-23. [PMID: 21352574] - Keiichiro Akamatsu, Kazuto Matsunaga, Hisatoshi Sugiura, Akira Koarai, Tsunahiko Hirano, Yoshiaki Minakata, Masakazu Ichinose. Improvement of Airflow Limitation by Fluticasone Propionate/Salmeterol in Chronic Obstructive Pulmonary Disease: What is the Specific Marker?.
Frontiers in pharmacology.
2011; 2(?):36. doi:
10.3389/fphar.2011.00036. [PMID: 21811461] - Jorge F Maspero, Hendrik Nolte, Iván Chérrez-Ojeda. Long-term safety of mometasone furoate/formoterol combination for treatment of patients with persistent asthma.
The Journal of asthma : official journal of the Association for the Care of Asthma.
2010 Dec; 47(10):1106-15. doi:
10.3109/02770903.2010.514634. [PMID: 20874458] - Teddy Kosoglou, David L Cutler, Heribert Staudinger, Jerry M Herron. Once-daily evening dosing of mometasone furoate administered via a dry powder inhaler does not adversely affect the hypothalamic-pituitary-adrenal axis.
Chest.
2010 Jan; 137(1):115-21. doi:
10.1378/chest.09-0235. [PMID: 19749003] - David P Skoner, Deborah A Gentile, Betty Angelini. Effect of therapeutic doses of mometasone furoate on cortisol levels in children with mild asthma.
Allergy and asthma proceedings.
2010 Jan; 31(1):10-9. doi:
10.2500/aap.2010.31.3305. [PMID: 20167141] - Yong-mei Li, Xiao-rui Li. [Effects of Qingshi Cream on chronic dermatitis-eczema in mice].
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine.
2009 Dec; 7(12):1164-6. doi:
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American journal of rhinology & allergy.
2009 Nov; 23(6):591-6. doi:
10.2500/ajra.2009.23.3391. [PMID: 19958608] - Beom Seok Seo, Hyun Jong Lee, Ji-Hun Mo, Chul Hee Lee, Chae-Seo Rhee, Jeong-Whun Kim. Treatment of postviral olfactory loss with glucocorticoids, Ginkgo biloba, and mometasone nasal spray.
Archives of otolaryngology--head & neck surgery.
2009 Oct; 135(10):1000-4. doi:
10.1001/archoto.2009.141. [PMID: 19841338] - Michael Noonan, Jeffrey Leflein, Jonathan Corren, Heribert Staudinger. Long-term safety of mometasone furoate administered via a dry powder inhaler in children: Results of an open-label study comparing mometasone furoate with beclomethasone dipropionate in children with persistent asthma.
BMC pediatrics.
2009 Jul; 9(?):43. doi:
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International archives of allergy and immunology.
2009; 148(2):154-60. doi:
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Immunopharmacology and immunotoxicology.
2009; 31(4):601-6. doi:
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Journal of asthma and allergy.
2008 Nov; 1(?):49-54. doi:
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Respiratory medicine.
2008 Oct; 102(10):1406-11. doi:
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Cutaneous and ocular toxicology.
2008; 27(1):1-3. doi:
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Veterinary therapeutics : research in applied veterinary medicine.
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Pharmacology.
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British journal of clinical pharmacology.
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Acta paediatrica (Oslo, Norway : 1992).
2007 Aug; 96(8):1233-7. doi:
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The Annals of pharmacotherapy.
2007 Jul; 41(7):1306-9. doi:
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British journal of clinical pharmacology.
2006 Oct; 62(4):412-9. doi:
10.1111/j.1365-2125.2006.02712.x. [PMID: 16995862] - S Sahasranaman, M Issar, G Hochhaus. Metabolism of mometasone furoate and biological activity of the metabolites.
Drug metabolism and disposition: the biological fate of chemicals.
2006 Feb; 34(2):225-33. doi:
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Advances in medical sciences.
2006; 51(?):242-4. doi:
NULL. [PMID: 17357317] - George P Chrousos, Lisa Ghaly, Arthur Shedden, Domenic G Iezzoni, Alan G Harris. Effects of mometasone furoate dry powder inhaler and beclomethasone dipropionate hydrofluoroalkane and chlorofluorocarbon on the hypothalamic-pituitary-adrenal axis in asthmatic subjects.
Chest.
2005 Jul; 128(1):70-7. doi:
10.1378/chest.128.1.70. [PMID: 16002918] - Srikumar Sahasranaman, Yufei Tang, Diana Biniasz, Guenther Hochhaus. A sensitive liquid chromatography-tandem mass spectrometry method for the quantification of mometasone furoate in human plasma.
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