Trovafloxacin (BioDeep_00001868376)
Main id: BioDeep_00000006573
代谢物信息卡片
Trovafloxacin
化学式: C20H15F3N4O3 (416.1096)
中文名称: 聚苯乙烯磺酸钙
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C1C2C(C2N)CN1C3=C(C=C4C(=O)C(=CN(C4=N3)C5=C(C=C(C=C5)F)F)C(=O)O)F
InChI: InChI=1S/C20H15F3N4O3/c21-8-1-2-15(13(22)3-8)27-7-12(20(29)30)17(28)9-4-14(23)19(25-18(9)27)26-5-10-11(6-26)16(10)24/h1-4,7,10-11,16H,5-6,24H2,(H,29,30)/t10-,11+,16+
描述信息
A 1,8-naphthyridine derivative that is 4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid bearing additional 2,4-difluorophenyl, fluoro and 6-amino-3-azabicyclo[3.1.0]hex-3-yl substituents at positions 1, 6 and 7 respectively. A broad-spectrum antibiotic that was withdrawn from the market due to risk of liver failure.
J - Antiinfectives for systemic use > J01 - Antibacterials for systemic use > J01M - Quinolone antibacterials > J01MA - Fluoroquinolones
D000970 - Antineoplastic Agents > D059003 - Topoisomerase Inhibitors > D059005 - Topoisomerase II Inhibitors
D000890 - Anti-Infective Agents > D000900 - Anti-Bacterial Agents > D024841 - Fluoroquinolones
C254 - Anti-Infective Agent > C258 - Antibiotic > C795 - Quinolone Antibiotic
D004791 - Enzyme Inhibitors
同义名列表
2 个代谢物同义名
数据库引用编号
13 个数据库交叉引用编号
- ChEBI: CHEBI:9763
- KEGG: C07664
- KEGGdrug: D08654
- PubChem: 62959
- DrugBank: DB00685
- ChEMBL: CHEMBL428
- CAS: 147059-72-1
- MetaboLights: MTBLC9763
- PubChem: 9866
- PDB-CCD: TR6
- NIKKAJI: J785.495A
- RefMet: Trovafloxacin
- KNApSAcK: 9763
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
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文献列表
- Giulio Giustarini, Nienke Vrisekoop, Laura Kruijssen, Laura Wagenaar, Selma van Staveren, Manon van Roest, Rob Bleumink, Marianne Bol-Schoenmakers, Richard J Weaver, Leo Koenderman, Joost Smit, Raymond Pieters. Trovafloxacin-Induced Liver Injury: Lack in Regulation of Inflammation by Inhibition of Nucleotide Release and Neutrophil Movement.
Toxicological sciences : an official journal of the Society of Toxicology.
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Nature communications.
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Xenobiotica; the fate of foreign compounds in biological systems.
2016 Sep; 46(9):784-92. doi:
10.3109/00498254.2015.1121554. [PMID: 26711252] - Jingtao Lu, Shannon Einhorn, Lata Venkatarangan, Manda Miller, David A Mann, Paul B Watkins, Edward LeCluyse. Morphological and Functional Characterization and Assessment of iPSC-Derived Hepatocytes for In Vitro Toxicity Testing.
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International journal of pharmaceutics.
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PloS one.
2015; 10(2):e0112655. doi:
10.1371/journal.pone.0112655. [PMID: 25689681] - Kyle L Poulsen, Jesus Olivero-Verbel, Kevin M Beggs, Patricia E Ganey, Robert A Roth. Trovafloxacin enhances lipopolysaccharide-stimulated production of tumor necrosis factor-α by macrophages: role of the DNA damage response.
The Journal of pharmacology and experimental therapeutics.
2014 Jul; 350(1):164-70. doi:
10.1124/jpet.114.214189. [PMID: 24817034] - Kyle L Poulsen, Ryan P Albee, Patricia E Ganey, Robert A Roth. Trovafloxacin potentiation of lipopolysaccharide-induced tumor necrosis factor release from RAW 264.7 cells requires extracellular signal-regulated kinase and c-Jun N-Terminal Kinase.
The Journal of pharmacology and experimental therapeutics.
2014 May; 349(2):185-91. doi:
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2014 Jan; 137(1):234-48. doi:
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Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
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The Journal of pharmacology and experimental therapeutics.
2009 Jul; 330(1):72-8. doi:
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Toxicology and applied pharmacology.
2009 May; 236(3):293-300. doi:
10.1016/j.taap.2009.01.018. [PMID: 19367693] - Patrick J Shaw, Amy C Ditewig, Jeffrey F Waring, Michael J Liguori, Eric A Blomme, Patricia E Ganey, Robert A Roth. Coexposure of mice to trovafloxacin and lipopolysaccharide, a model of idiosyncratic hepatotoxicity, results in a unique gene expression profile and interferon gamma-dependent liver injury.
Toxicological sciences : an official journal of the Society of Toxicology.
2009 Jan; 107(1):270-80. doi:
10.1093/toxsci/kfn205. [PMID: 18930950] - Patrick J Shaw, Patricia E Ganey, Robert A Roth. Tumor necrosis factor alpha is a proximal mediator of synergistic hepatotoxicity from trovafloxacin/lipopolysaccharide coexposure.
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2008 Jul; 36(7):1385-405. doi:
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The Journal of antimicrobial chemotherapy.
2008 Mar; 61(3):561-7. doi:
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Toxicological sciences : an official journal of the Society of Toxicology.
2007 Nov; 100(1):259-66. doi:
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The Journal of pharmacology and experimental therapeutics.
2006 Mar; 316(3):1080-7. doi:
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Clinical therapeutics.
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Diagnostic microbiology and infectious disease.
2005 Feb; 51(2):103-11. doi:
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Antimicrobial agents and chemotherapy.
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The Journal of antimicrobial chemotherapy.
2004 Feb; 53(2):252-7. doi:
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Drug safety.
2004; 27(9):671-86. doi:
10.2165/00002018-200427090-00005. [PMID: 15230648] - Irina S Barequet, Paul Denton, Gerard J Osterhout, Suhas Tuli, Terrence P O'Brien. Treatment of experimental bacterial keratitis with topical trovafloxacin.
Archives of ophthalmology (Chicago, Ill. : 1960).
2004 Jan; 122(1):65-9. doi:
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Clinical orthopaedics and related research.
2003 Sep; ?(414):95-100. doi:
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Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases.
2003 Jul; 9(7):670-7. doi:
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European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology.
2003 Apr; 22(4):203-21. doi:
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Journal of pharmaceutical and biomedical analysis.
2003 Mar; 31(3):465-71. doi:
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Clinical cornerstone.
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International journal of antimicrobial agents.
2002 Dec; 20(6):477-80. doi:
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International journal of antimicrobial agents.
2002 Aug; 20(2):144-6. doi:
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
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Pharmacotherapy.
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The Annals of pharmacotherapy.
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Drugs.
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JAMA.
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Chemotherapy.
2001 Dec; 47(6):409-14. doi:
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2001 Oct; 35(10):1194-8. doi:
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The Journal of infectious diseases.
2001 Sep; 184(6):794-8. doi:
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International journal of antimicrobial agents.
2001 Sep; 18(3):231-8. doi:
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European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2001 Jun; 13(3):297-301. doi:
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Regulatory toxicology and pharmacology : RTP.
2001 Jun; 33(3):276-84. doi:
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Scandinavian journal of infectious diseases.
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2001 Jan; 17(1):33-7. doi:
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2000 Dec; 46(6):921-9. doi:
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