Guanosine-5-diphosphate (BioDeep_00001868316)
Main id: BioDeep_00000001615
PANOMIX_OTCML-2023 BioNovoGene_Lab2019
代谢物信息卡片
化学式: C10H15N5O11P2 (443.0243)
中文名称: 鸟苷-5-二磷酸
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: C([C@@H]1[C@H]([C@H]([C@H](n2cnc3c2nc(N)[nH]c3=O)O1)O)O)OP(=O)(O)OP(=O)(O)O
InChI: InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
描述信息
A purine ribonucleoside 5-diphosphate resulting from the formal condensation of the hydroxy group at the 5 position of guanosine with pyrophosphoric acid.
COVID info from COVID-19 Disease Map, PDB, Protein Data Bank
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
3 个代谢物同义名
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:17552
- KEGG: C00035
- PubChem: 135398619
- DrugBank: DB04315
- ChEMBL: CHEMBL384759
- MeSH: Guanosine Diphosphate
- CAS: 157420-46-7
- CAS: 105184-46-1
- CAS: 81149-12-4
- CAS: 146-91-8
- MetaboLights: MTBLC17552
- PubChem: 3337
- PDB-CCD: GDP
- 3DMET: B01135
- NIKKAJI: J40.056D
- RefMet: GDP
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-256
- KNApSAcK: 17552
分类词条
相关代谢途径
Reactome(29)
- Metabolism
- Disease
- Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism
- Developmental Biology
- Signaling Pathways
- Mycobacterium tuberculosis biological processes
- Sulfur compound metabolism
- Signaling by Receptor Tyrosine Kinases
- Signaling by VEGF
- VEGFA-VEGFR2 Pathway
- Infectious disease
- Integration of energy metabolism
- Neuronal System
- Transmission across Chemical Synapses
- HIV Infection
- Host Interactions of HIV factors
- Metabolism of RNA
- Viral Infection Pathways
- Signaling by GPCR
- GPCR downstream signalling
- G alpha (i) signalling events
- Hemostasis
- Opioid Signalling
- Platelet homeostasis
- Signaling by Nuclear Receptors
- ESR-mediated signaling
- Extra-nuclear estrogen signaling
- Death Receptor Signaling
- p75 NTR receptor-mediated signalling
BioCyc(10)
- purine and pyrimidine metabolism
- purine nucleotide metabolism (phosphotransfer and nucleotide modification)
- purine nucleotides de novo biosynthesis I
- superpathway of histidine, purine, and pyrimidine biosynthesis
- purine nucleotides de novo biosynthesis II
- salvage pathways of purine nucleosides I
- superpathway of central carbon metabolism
- lipophosphoglycan (LPG) biosynthesis
- glycoinositolphospholipid (GIPL) biosynthesis
- sphingolipid metabolism
PlantCyc(9)
- pyrimidine salvage pathway
- protein N-glycosylation initial phase (eukaryotic)
- superpathway of adenosine nucleotides de novo biosynthesis I
- superpathway of purine nucleotides de novo biosynthesis I
- guanosine ribonucleotides de novo biosynthesis
- adenosine ribonucleotides de novo biosynthesis
- UDP-α-D-glucuronate biosynthesis (from myo-inositol)
- L-ascorbate biosynthesis II (plants, L-gulose pathway)
- ppGpp biosynthesis
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
3 个相关的物种来源信息
- 654 - Aeromonas veronii: 10.3389/FCIMB.2020.00044
- 3702 - Arabidopsis thaliana:
- 9606 - Homo sapiens: 10.1007/S11306-016-1051-4
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:
- PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。
文献列表
- Xiangning Liu, Xiang Yu, Yue Shi, Liang Ma, Ying Fu, Yan Guo. Phosphorylation of RhoGDI1, a Rho GDP dissociation inhibitor, regulates root hair development in Arabidopsis under salt stress.
Proceedings of the National Academy of Sciences of the United States of America.
2023 08; 120(34):e2217957120. doi:
10.1073/pnas.2217957120
. [PMID: 37590409] - H Y Bao, W Wang, H B Sun, J Z Chen. Binding modes of GDP, GTP and GNP to NRAS deciphered by using Gaussian accelerated molecular dynamics simulations.
SAR and QSAR in environmental research.
2023 Jan; 34(1):65-89. doi:
10.1080/1062936x.2023.2165542
. [PMID: 36762439] - Bowen Zhan, Yanqing Gao, Wenqing Gao, Ye Li, Zhengyang Li, Qi Qi, Xin Lan, Hongbo Shen, Jianhua Gan, Guoping Zhao, Jixi Li. Structural insights of the elongation factor EF-Tu complexes in protein translation of Mycobacterium tuberculosis.
Communications biology.
2022 10; 5(1):1052. doi:
10.1038/s42003-022-04019-y
. [PMID: 36192483] - Giang Pham, Dong-Min Shin, Yoon Kim, Soo-Hwan Kim. Ran-GTP/-GDP-dependent nuclear accumulation of NONEXPRESSOR OF PATHOGENESIS-RELATED GENES1 and TGACG-BINDING FACTOR2 controls salicylic acid-induced leaf senescence.
Plant physiology.
2022 06; 189(3):1774-1793. doi:
10.1093/plphys/kiac164
. [PMID: 35417014] - Yuan Chen, Peng Shu, Ruochen Wang, Xiaofei Du, Yue Xie, Kui Du, Heng Deng, Mingzhang Li, Yang Zhang, Don Grierson, Mingchun Liu. Ethylene response factor AcERF91 affects ascorbate metabolism via regulation of GDP-galactose phosphorylase encoding gene (AcGGP3) in kiwifruit.
Plant science : an international journal of experimental plant biology.
2021 Dec; 313(?):111063. doi:
10.1016/j.plantsci.2021.111063
. [PMID: 34763857] - Hiroshi Senoo, Daisuke Murata, May Wai, Kenta Arai, Wakiko Iwata, Hiromi Sesaki, Miho Iijima. KARATE: PKA-induced KRAS4B-RHOA-mTORC2 supercomplex phosphorylates AKT in insulin signaling and glucose homeostasis.
Molecular cell.
2021 11; 81(22):4622-4634.e8. doi:
10.1016/j.molcel.2021.09.001
. [PMID: 34551282] - Natsumi Maruta, Yuri Trusov, Alan M Jones, Jose R Botella. Heterotrimeric G Proteins in Plants: Canonical and Atypical Gα Subunits.
International journal of molecular sciences.
2021 Oct; 22(21):. doi:
10.3390/ijms222111841
. [PMID: 34769272] - Ying Liu, Xiaoyun Wang, Danhui Dong, Luqin Guo, Xiaonan Dong, Jing Leng, Bing Zhao, Yang-Dong Guo, Na Zhang. Research Advances in Heterotrimeric G-Protein α Subunits and Uncanonical G-Protein Coupled Receptors in Plants.
International journal of molecular sciences.
2021 Aug; 22(16):. doi:
10.3390/ijms22168678
. [PMID: 34445383] - Jianzhong Chen, Lifei Wang, Wei Wang, Haibo Sun, Laixue Pang, Huayin Bao. Conformational transformation of switch domains in GDP/K-Ras induced by G13 mutants: An investigation through Gaussian accelerated molecular dynamics simulations and principal component analysis.
Computers in biology and medicine.
2021 08; 135(?):104639. doi:
10.1016/j.compbiomed.2021.104639
. [PMID: 34247129] - Mario Fenech, Vítor Amorim-Silva, Alicia Esteban Del Valle, Dominique Arnaud, Noemi Ruiz-Lopez, Araceli G Castillo, Nicholas Smirnoff, Miguel A Botella. The role of GDP-l-galactose phosphorylase in the control of ascorbate biosynthesis.
Plant physiology.
2021 04; 185(4):1574-1594. doi:
10.1093/plphys/kiab010
. [PMID: 33793952] - Meng Zhang, Miao Gui, Zi-Fu Wang, Christoph Gorgulla, James J Yu, Hao Wu, Zhen-Yu J Sun, Christoph Klenk, Lisa Merklinger, Lena Morstein, Franz Hagn, Andreas Plückthun, Alan Brown, Mahmoud L Nasr, Gerhard Wagner. Cryo-EM structure of an activated GPCR-G protein complex in lipid nanodiscs.
Nature structural & molecular biology.
2021 03; 28(3):258-267. doi:
10.1038/s41594-020-00554-6
. [PMID: 33633398] - Toshihiro Kishikawa, Yuichi Maeda, Takuro Nii, Noriko Arase, Jun Hirata, Ken Suzuki, Kenichi Yamamoto, Tatsuo Masuda, Kotaro Ogawa, Shigeyoshi Tsuji, Masato Matsushita, Hidetoshi Matsuoka, Maiko Yoshimura, Shinichiro Tsunoda, Shiro Ohshima, Masashi Narazaki, Atsushi Ogata, Yukihiko Saeki, Hidenori Inohara, Atsushi Kumanogoh, Kiyoshi Takeda, Yukinori Okada. Increased levels of plasma nucleotides in patients with rheumatoid arthritis.
International immunology.
2021 01; 33(2):119-124. doi:
10.1093/intimm/dxaa059
. [PMID: 32866240] - Andrés Tolosa-Díaz, Víctor G Almendro-Vedia, Paolo Natale, Iván López-Montero. The GDP-Bound State of Mitochondrial Mfn1 Induces Membrane Adhesion of Apposing Lipid Vesicles through a Cooperative Binding Mechanism.
Biomolecules.
2020 07; 10(7):. doi:
10.3390/biom10071085
. [PMID: 32708307] - Li Wan, Yingying Zhu, Wen Li, Wenli Zhang, Wanmeng Mu. Combinatorial Modular Pathway Engineering for Guanosine 5'-Diphosphate-l-fucose Production in Recombinant Escherichia coli.
Journal of agricultural and food chemistry.
2020 May; 68(20):5668-5675. doi:
10.1021/acs.jafc.0c01064
. [PMID: 32336091] - Liming Yan, Yuanbo Qi, Derek Ricketson, Lei Li, Kelly Subramanian, Jinghua Zhao, Caiting Yu, Lijie Wu, Reta Sarsam, Melissa Wong, Zhiyong Lou, Zihe Rao, Jodi Nunnari, Junjie Hu. Structural analysis of a trimeric assembly of the mitochondrial dynamin-like GTPase Mgm1.
Proceedings of the National Academy of Sciences of the United States of America.
2020 02; 117(8):4061-4070. doi:
10.1073/pnas.1919116117
. [PMID: 32041880] - Matías L Alegre, Charlotte Steelheart, Pierre Baldet, Christophe Rothan, Daniel Just, Yoshihiro Okabe, Hiroshi Ezura, Nicholas Smirnoff, Gustavo E Gergoff Grozeff, Carlos G Bartoli. Deficiency of GDP-L-galactose phosphorylase, an enzyme required for ascorbic acid synthesis, reduces tomato fruit yield.
Planta.
2020 Jan; 251(2):54. doi:
10.1007/s00425-020-03345-x
. [PMID: 31970534] - Sanchaita Das, Andrew W Malaby, Agata Nawrotek, Wenhua Zhang, Mahel Zeghouf, Sarah Maslen, Mark Skehel, Srinivas Chakravarthy, Thomas C Irving, Osman Bilsel, Jacqueline Cherfils, David G Lambright. Structural Organization and Dynamics of Homodimeric Cytohesin Family Arf GTPase Exchange Factors in Solution and on Membranes.
Structure (London, England : 1993).
2019 12; 27(12):1782-1797.e7. doi:
10.1016/j.str.2019.09.007
. [PMID: 31601460] - Ron Orbach, Jonathon Howard. The dynamic and structural properties of axonemal tubulins support the high length stability of cilia.
Nature communications.
2019 04; 10(1):1838. doi:
10.1038/s41467-019-09779-6
. [PMID: 31015426] - Pradeep Bandaru, Yasushi Kondo, John Kuriyan. The Interdependent Activation of Son-of-Sevenless and Ras.
Cold Spring Harbor perspectives in medicine.
2019 02; 9(2):. doi:
10.1101/cshperspect.a031534
. [PMID: 29610148] - Toshihide Kimura, Mami Yamaoka, Takeshi Terabayashi, Kozo Kaibuchi, Tomohisa Ishikawa, Toshimasa Ishizaki. GDP-Bound Rab27a Dissociates from the Endocytic Machinery in a Phosphorylation-Dependent Manner after Insulin Secretion.
Biological & pharmaceutical bulletin.
2019; 42(9):1532-1537. doi:
10.1248/bpb.b19-00242
. [PMID: 31474712] - Stanzin Angmo, Shilpa Rana, Kamalendra Yadav, Rajat Sandhir, Nitin Kumar Singhal. Novel Liposome Eencapsulated Guanosine Di Phosphate based Therapeutic Target against Anemia of Inflammation.
Scientific reports.
2018 12; 8(1):17684. doi:
10.1038/s41598-018-35992-2
. [PMID: 30523271] - Tomohiro Shima, Manatsu Morikawa, Junichi Kaneshiro, Taketoshi Kambara, Shinji Kamimura, Toshiki Yagi, Hiroyuki Iwamoto, Sotaro Uemura, Hideki Shigematsu, Mikako Shirouzu, Taro Ichimura, Tomonobu M Watanabe, Ryo Nitta, Yasushi Okada, Nobutaka Hirokawa. Kinesin-binding-triggered conformation switching of microtubules contributes to polarized transport.
The Journal of cell biology.
2018 12; 217(12):4164-4183. doi:
10.1083/jcb.201711178
. [PMID: 30297389] - Kelsey N Maxwell, Yong Zhou, John F Hancock. Rac1 Nanoscale Organization on the Plasma Membrane Is Driven by Lipid Binding Specificity Encoded in the Membrane Anchor.
Molecular and cellular biology.
2018 09; 38(18):. doi:
10.1128/mcb.00186-18
. [PMID: 29967243] - Dan Dan Xu, Chong Bing Xu, Hon Ming Lam, Fuk-Ling Wong, Albert Wing Nang Leung, Merrin Man Long Leong, William Chi Shing Cho, Robin Hoeven, Qingtao Lv, Rong Rong. Proteomic analysis reveals that pheophorbide a-mediated photodynamic treatment inhibits prostate cancer growth by hampering GDP-GTP exchange of ras-family proteins.
Photodiagnosis and photodynamic therapy.
2018 Sep; 23(?):35-39. doi:
10.1016/j.pdpdt.2018.05.014
. [PMID: 29800714] - Jiwei Liu, Jeffrey K Noel, Harry H Low. Structural basis for membrane tethering by a bacterial dynamin-like pair.
Nature communications.
2018 08; 9(1):3345. doi:
10.1038/s41467-018-05523-8
. [PMID: 30131557] - Magdalena Blom, Katarina Reis, Pontus Aspenström. RhoD localization and function is dependent on its GTP/GDP-bound state and unique N-terminal motif.
European journal of cell biology.
2018 Aug; 97(6):393-401. doi:
10.1016/j.ejcb.2018.05.003
. [PMID: 29776664] - Min Woo Sung, Rahamthulla Shaik, Allan D TerBush, Katherine W Osteryoung, Stanislav Vitha, Andreas Holzenburg. The chloroplast division protein ARC6 acts to inhibit disassembly of GDP-bound FtsZ2.
The Journal of biological chemistry.
2018 07; 293(27):10692-10706. doi:
10.1074/jbc.ra117.000999
. [PMID: 29769312] - Naomi Matsumoto, Mizuki Sekiya, Koujiro Tohyama, Eri Ishiyama-Matsuura, Ge-Hong Sun-Wada, Yoh Wada, Masamitsu Futai, Mayumi Nakanishi-Matsui. Essential Role of the a3 Isoform of V-ATPase in Secretory Lysosome Trafficking via Rab7 Recruitment.
Scientific reports.
2018 04; 8(1):6701. doi:
10.1038/s41598-018-24918-7
. [PMID: 29712939] - Xifeng Li, Chong Cai, Zhe Wang, Baofang Fan, Cheng Zhu, Zhixiang Chen. Plastid Translation Elongation Factor Tu Is Prone to Heat-Induced Aggregation Despite Its Critical Role in Plant Heat Tolerance.
Plant physiology.
2018 04; 176(4):3027-3045. doi:
10.1104/pp.17.01672
. [PMID: 29444814] - Anna K Shishina, Elizaveta A Kovrigina, Azamat R Galiakhmetov, Rajendra Rathore, Evgenii L Kovrigin. Study of Förster Resonance Energy Transfer to Lipid Domain Markers Ascertains Partitioning of Semisynthetic Lipidated N-Ras in Lipid Raft Nanodomains.
Biochemistry.
2018 02; 57(5):872-881. doi:
10.1021/acs.biochem.7b01181
. [PMID: 29280621] - Vanitha Sagar Sudam, Ajay Godwin Potnuri, N J Prameela Subhashini. Syk - GTP RAC-1 mediated immune-stimulatory effect of Cuscuta epithymum, Ipomoea batata and Euphorbia hirta plant extracts.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2017 Dec; 96(?):742-749. doi:
10.1016/j.biopha.2017.10.060
. [PMID: 29049977] - Marta Sobrinos-Sanguino, Silvia Zorrilla, Begoña Monterroso, Allen P Minton, Germán Rivas. Nucleotide and receptor density modulate binding of bacterial division FtsZ protein to ZipA containing lipid-coated microbeads.
Scientific reports.
2017 10; 7(1):13707. doi:
10.1038/s41598-017-14160-y
. [PMID: 29057931] - Lokwern Chan, Jin Hong, Junjie Pan, Jian Li, Zhichao Wen, Haiming Shi, Jianping Ding, Xinping Luo. Role of Rab5 in the formation of macrophage-derived foam cell.
Lipids in health and disease.
2017 Sep; 16(1):170. doi:
10.1186/s12944-017-0559-6
. [PMID: 28899395] - Dario De Vecchis, Laetitia Cavellini, Marc Baaden, Jérôme Hénin, Mickaël M Cohen, Antoine Taly. A membrane-inserted structural model of the yeast mitofusin Fzo1.
Scientific reports.
2017 08; 7(1):10217. doi:
10.1038/s41598-017-10687-2
. [PMID: 28860650] - Bing Li, Luping Liu, Ying Li, Xin Dong, Haifeng Zhang, Huaigu Chen, Xiaobo Zheng, Zhengguang Zhang. The FgVps39-FgVam7-FgSso1 Complex Mediates Vesicle Trafficking and Is Important for the Development and Virulence of Fusarium graminearum.
Molecular plant-microbe interactions : MPMI.
2017 05; 30(5):410-422. doi:
10.1094/mpmi-11-16-0242-r
. [PMID: 28437167] - Karima Farhat, Caroline E Douma, E Ferrantelli, Pieter M Ter Wee, Robert H J Beelen, Frans J van Ittersum. Effects of Conversion to a Bicarbonate/Lactate-Buffered, Neutral-pH, Low-GDP PD Regimen in Prevalent PD: A 2-Year Randomized Clinical Trial.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis.
2017 May; 37(3):273-282. doi:
10.3747/pdi.2015.00031
. [PMID: 28348100] - Kazue Sugiyama, Kenji Tago, Sayumi Matsushita, Masashi Nishikawa, Katsuya Sato, Yoshinori Muto, Takahiro Nagase, Hiroshi Ueda. Heterotrimeric G protein Gαs subunit attenuates PLEKHG2, a Rho family-specific guanine nucleotide exchange factor, by direct interaction.
Cellular signalling.
2017 04; 32(?):115-123. doi:
10.1016/j.cellsig.2017.01.022
. [PMID: 28108261] - Yongheng Rong, Kun Wang, Renxing Shi, Xiaomin Hou, Chun-Hai Dong. Expression, purification and characterization of ROP66-178 GTPase from Arabidopsis thaliana.
Protein expression and purification.
2017 03; 131(?):1-6. doi:
10.1016/j.pep.2016.10.009
. [PMID: 27789389] - Paraish S Misra, Sharon J Nessim, Jeffrey Perl. 'Biocompatible' Neutral pH Low-GDP Peritoneal Dialysis Solutions: Much Ado About Nothing?.
Seminars in dialysis.
2017 03; 30(2):164-173. doi:
10.1111/sdi.12579
. [PMID: 28251697] - Siri C van Keulen, Ursula Rothlisberger. Effect of N-Terminal Myristoylation on the Active Conformation of Gαi1-GTP.
Biochemistry.
2017 Jan; 56(1):271-280. doi:
10.1021/acs.biochem.6b00388
. [PMID: 27936598] - Berit Ebert, Carsten Rautengarten, Joshua L Heazlewood. GDP-L-fucose transport in plants: The missing piece.
Channels (Austin, Tex.).
2017 01; 11(1):8-10. doi:
10.1080/19336950.2016.1222760
. [PMID: 27588459] - Stephanie Voss, Dennis M Krüger, Oliver Koch, Yao-Wen Wu. Spatiotemporal imaging of small GTPases activity in live cells.
Proceedings of the National Academy of Sciences of the United States of America.
2016 12; 113(50):14348-14353. doi:
10.1073/pnas.1613999113
. [PMID: 27911813] - Takahisa Ogawa, Shigeru Shigeoka, Kazuya Yoshimura. [Recent advances in functional analysis of plant Nudix hydrolase family—novel roles of metabolic regulation of GDP-D-mannose and NADH—].
Seikagaku. The Journal of Japanese Biochemical Society.
2016 Dec; 88(6):752-5. doi:
. [PMID: 29624349]
- Mark P V Begieneman, Ellis N Ter Horst, Liza Rijvers, Elisa Meinster, René Leen, Jeannette E Pankras, Jan Fritz, Bela Kubat, René J P Musters, André B P van Kuilenburg, Jan Stap, Hans W M Niessen, Paul A J Krijnen. Dopamine induces lipid accumulation, NADPH oxidase-related oxidative stress, and a proinflammatory status of the plasma membrane in H9c2 cells.
American journal of physiology. Heart and circulatory physiology.
2016 11; 311(5):H1097-H1107. doi:
10.1152/ajpheart.00633.2015
. [PMID: 27521422] - Yan Hong, Ting Zhao, Xiao-Jiang Li, Shihua Li. Mutant Huntingtin Impairs BDNF Release from Astrocytes by Disrupting Conversion of Rab3a-GTP into Rab3a-GDP.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2016 08; 36(34):8790-801. doi:
10.1523/jneurosci.0168-16.2016
. [PMID: 27559163] - Yoshinobu Hara, Masahiro Fukaya, Kanehiro Hayashi, Takeshi Kawauchi, Kazunori Nakajima, Hiroyuki Sakagami. ADP Ribosylation Factor 6 Regulates Neuronal Migration in the Developing Cerebral Cortex through FIP3/Arfophilin-1-dependent Endosomal Trafficking of N-cadherin.
eNeuro.
2016 Jul; 3(4):. doi:
10.1523/eneuro.0148-16.2016
. [PMID: 27622210] - Jeroen P Kooman, Tom Cornelis, Frank M van der Sande, Karel M L Leunissen. Is the Effect of Low-GDP Solutions on Residual Renal Function Mediated by Fluid State? An Enigmatic Question which Still Needs to be Solved.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis.
2016 May; 36(3):239-42. doi:
10.3747/pdi.2015.00149
. [PMID: 27230598] - Yi Gao, Lingling Tan, Chun-Hai Dong, Xiaomin Hou. Expression, purification and guanine nucleotide binding characterization of Arabidopsis RabE1d13-185 GTPase.
Protein expression and purification.
2016 Mar; 119(?):57-62. doi:
10.1016/j.pep.2015.11.013
. [PMID: 26611608] - Shaoyong Lu, Avik Banerjee, Hyunbum Jang, Jian Zhang, Vadim Gaponenko, Ruth Nussinov. GTP Binding and Oncogenic Mutations May Attenuate Hypervariable Region (HVR)-Catalytic Domain Interactions in Small GTPase K-Ras4B, Exposing the Effector Binding Site.
The Journal of biological chemistry.
2015 Nov; 290(48):28887-900. doi:
10.1074/jbc.m115.664755
. [PMID: 26453300] - Shobhna Kapoor, Eyad K Fansa, Simone Möbitz, Shehab A Ismail, Roland Winter, Alfred Wittinghofer, Katrin Weise. Effect of the N-Terminal Helix and Nucleotide Loading on the Membrane and Effector Binding of Arl2/3.
Biophysical journal.
2015 Oct; 109(8):1619-29. doi:
10.1016/j.bpj.2015.08.033
. [PMID: 26488653] - Liming Yan, Sha Sun, Wei Wang, Juanming Shi, Xiaoyu Hu, Shiyan Wang, Dan Su, Zihe Rao, Junjie Hu, Zhiyong Lou. Structures of the yeast dynamin-like GTPase Sey1p provide insight into homotypic ER fusion.
The Journal of cell biology.
2015 Sep; 210(6):961-72. doi:
10.1083/jcb.201502078
. [PMID: 26370501] - Juha-Pekka Mattila, Anna V Shnyrova, Anna C Sundborger, Eva Rodriguez Hortelano, Marc Fuhrmans, Sylvia Neumann, Marcus Müller, Jenny E Hinshaw, Sandra L Schmid, Vadim A Frolov. A hemi-fission intermediate links two mechanistically distinct stages of membrane fission.
Nature.
2015 Aug; 524(7563):109-113. doi:
10.1038/nature14509
. [PMID: 26123023] - Chitra Bhatia, Stephanie Oerum, James Bray, Kathryn L Kavanagh, Naeem Shafqat, Wyatt Yue, Udo Oppermann. Towards a systematic analysis of human short-chain dehydrogenases/reductases (SDR): Ligand identification and structure-activity relationships.
Chemico-biological interactions.
2015 Jun; 234(?):114-25. doi:
10.1016/j.cbi.2014.12.013
. [PMID: 25526675] - Maria V Yamburenko, Yan O Zubo, Thomas Börner. Abscisic acid affects transcription of chloroplast genes via protein phosphatase 2C-dependent activation of nuclear genes: repression by guanosine-3'-5'-bisdiphosphate and activation by sigma factor 5.
The Plant journal : for cell and molecular biology.
2015 Jun; 82(6):1030-1041. doi:
10.1111/tpj.12876
. [PMID: 25976841] - Leonardo E Pelletán, Laila Suhaiman, Cintia C Vaquer, Matías A Bustos, Gerardo A De Blas, Nicolas Vitale, Luis S Mayorga, Silvia A Belmonte. ADP ribosylation factor 6 (ARF6) promotes acrosomal exocytosis by modulating lipid turnover and Rab3A activation.
The Journal of biological chemistry.
2015 Apr; 290(15):9823-41. doi:
10.1074/jbc.m114.629006
. [PMID: 25713146] - Pascal Arnoux, Christian Ruppelt, Flore Oudouhou, Jérôme Lavergne, Marina I Siponen, René Toci, Ralf R Mendel, Florian Bittner, David Pignol, Axel Magalon, Anne Walburger. Sulphur shuttling across a chaperone during molybdenum cofactor maturation.
Nature communications.
2015 Feb; 6(?):6148. doi:
10.1038/ncomms7148
. [PMID: 25649206] - Cyrielle Kint, Natalie Verstraeten, Johan Hofkens, Maarten Fauvart, Jan Michiels. Bacterial Obg proteins: GTPases at the nexus of protein and DNA synthesis.
Critical reviews in microbiology.
2014 Aug; 40(3):207-24. doi:
10.3109/1040841x.2013.776510
. [PMID: 23537324] - Weiwei Wang, Matthew R Whorton, Roderick MacKinnon. Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system.
eLife.
2014 Jul; 3(?):e03671. doi:
10.7554/elife.03671
. [PMID: 25049222] - Christina Lumme, Hasret Altan-Martin, Reza Dastvan, Maik S Sommer, Mislav Oreb, Denise Schuetz, Björn Hellenkamp, Oliver Mirus, Jens Kretschmer, Sevdalina Lyubenova, Wolfgang Kügel, Jan P Medelnik, Manuela Dehmer, Jens Michaelis, Thomas F Prisner, Thorsten Hugel, Enrico Schleiff. Nucleotides and substrates trigger the dynamics of the Toc34 GTPase homodimer involved in chloroplast preprotein translocation.
Structure (London, England : 1993).
2014 Apr; 22(4):526-38. doi:
10.1016/j.str.2014.02.004
. [PMID: 24631462] - Andrzej M Woyda-Ploszczyca, Wieslawa Jarmuszkiewicz. Different effects of guanine nucleotides (GDP and GTP) on protein-mediated mitochondrial proton leak.
PloS one.
2014; 9(6):e98969. doi:
10.1371/journal.pone.0098969
. [PMID: 24904988] - Irina G Shabalina, Natasa Petrovic, Jasper M A de Jong, Anastasia V Kalinovich, Barbara Cannon, Jan Nedergaard. UCP1 in brite/beige adipose tissue mitochondria is functionally thermogenic.
Cell reports.
2013 Dec; 5(5):1196-203. doi:
10.1016/j.celrep.2013.10.044
. [PMID: 24290753] - Kyouhei Asano, Jung-Bum Lee, Yoshimi Yamamura, Fumiya Kurosaki. Enhanced accumulation of atropine in Atropa belladonna transformed by Rac GTPase gene isolated from Scoparia dulcis.
Transgenic research.
2013 Dec; 22(6):1249-55. doi:
10.1007/s11248-013-9733-4
. [PMID: 23852262] - Marc Anderson, Eun Young Kim, Henning Hagmann, Thomas Benzing, Stuart E Dryer. Opposing effects of podocin on the gating of podocyte TRPC6 channels evoked by membrane stretch or diacylglycerol.
American journal of physiology. Cell physiology.
2013 Aug; 305(3):C276-89. doi:
10.1152/ajpcell.00095.2013
. [PMID: 23657570] - Shobhna Kapoor, Alexander Werkmüller, Roger S Goody, Herbert Waldmann, Roland Winter. Pressure modulation of Ras-membrane interactions and intervesicle transfer.
Journal of the American Chemical Society.
2013 Apr; 135(16):6149-56. doi:
10.1021/ja312671j
. [PMID: 23560466] - A Grunwald, I Gottfried, A D Cox, R Haklai, Y Kloog, U Ashery. Rasosomes originate from the Golgi to dispense Ras signals.
Cell death & disease.
2013 Feb; 4(?):e496. doi:
10.1038/cddis.2013.16
. [PMID: 23412389] - Myung Ki Min, Mihue Jang, Myounghui Lee, Junho Lee, Kyungyoung Song, Yongjik Lee, Kwan Yong Choi, David G Robinson, Inhwan Hwang. Recruitment of Arf1-GDP to Golgi by Glo3p-type ArfGAPs is crucial for golgi maintenance and plant growth.
Plant physiology.
2013 Feb; 161(2):676-91. doi:
10.1104/pp.112.209148
. [PMID: 23266962] - Yunfan Yang, Lei Sun, Tala, Jinmin Gao, Dengwen Li, Jun Zhou, Min Liu. CYLD regulates RhoA activity by modulating LARG ubiquitination.
PloS one.
2013; 8(2):e55833. doi:
10.1371/journal.pone.0055833
. [PMID: 23405219] - T Nakagawa, K Nagayasu, N Nishitani, H Shirakawa, K Sekiguchi, Y Ikarashi, Y Kase, S Kaneko. Yokukansan inhibits morphine tolerance and physical dependence in mice: the role of α₂A-adrenoceptor.
Neuroscience.
2012 Dec; 227(?):336-49. doi:
10.1016/j.neuroscience.2012.09.079
. [PMID: 23069764] - Casey O'Connor, Evgenii L Kovrigin. Characterization of the second ion-binding site in the G domain of H-Ras.
Biochemistry.
2012 Dec; 51(48):9638-46. doi:
10.1021/bi301304g
. [PMID: 23148511] - Tsan-Yu Chiu, Katy Christiansen, Ignacio Moreno, Jeemeng Lao, Dominique Loqué, Ariel Orellana, Joshua L Heazlewood, Greg Clark, Stanley J Roux. AtAPY1 and AtAPY2 function as Golgi-localized nucleoside diphosphatases in Arabidopsis thaliana.
Plant & cell physiology.
2012 Nov; 53(11):1913-25. doi:
10.1093/pcp/pcs131
. [PMID: 23034877] - Ifigeneia Mellidou, David Chagné, William A Laing, Johan Keulemans, Mark W Davey. Allelic variation in paralogs of GDP-L-galactose phosphorylase is a major determinant of vitamin C concentrations in apple fruit.
Plant physiology.
2012 Nov; 160(3):1613-29. doi:
10.1104/pp.112.203786
. [PMID: 23001142] - Shobhna Kapoor, Katrin Weise, Mirko Erlkamp, Gemma Triola, Herbert Waldmann, Roland Winter. The role of G-domain orientation and nucleotide state on the Ras isoform-specific membrane interaction.
European biophysics journal : EBJ.
2012 Oct; 41(10):801-13. doi:
10.1007/s00249-012-0841-5
. [PMID: 22851002] - Martin Jastroch, Verena Hirschberg, Martin Klingenspor. Functional characterization of UCP1 in mammalian HEK293 cells excludes mitochondrial uncoupling artefacts and reveals no contribution to basal proton leak.
Biochimica et biophysica acta.
2012 Sep; 1817(9):1660-70. doi:
10.1016/j.bbabio.2012.05.014
. [PMID: 22676960] - Vincent Neyraud, Vasily N Aushev, Anastassia Hatzoglou, Brigitte Meunier, Ilaria Cascone, Jacques Camonis. RalA and RalB proteins are ubiquitinated GTPases, and ubiquitinated RalA increases lipid raft exposure at the plasma membrane.
The Journal of biological chemistry.
2012 Aug; 287(35):29397-405. doi:
10.1074/jbc.m112.357764
. [PMID: 22700969] - Ravi K Nookala, Lars Langemeyer, Angela Pacitto, Bernardo Ochoa-Montaño, Jane C Donaldson, Beata K Blaszczyk, Dimitri Y Chirgadze, Francis A Barr, J Fernando Bazan, Tom L Blundell. Crystal structure of folliculin reveals a hidDENN function in genetically inherited renal cancer.
Open biology.
2012 Aug; 2(8):120071. doi:
10.1098/rsob.120071
. [PMID: 22977732] - Haixia Liang, Jing Xu, Dan Zhao, Huaru Tian, Xuxia Yang, Aihua Liang, Wei Wang. Subcellular localization and role of Ran1 in Tetrahymena thermophila amitotic macronucleus.
The FEBS journal.
2012 Jul; 279(14):2520-33. doi:
10.1111/j.1742-4658.2012.08634.x
. [PMID: 22594798] - Fiorella Belotti, Renata Tisi, Chiara Paiardi, Marco Rigamonti, Silvia Groppi, Enzo Martegani. Localization of Ras signaling complex in budding yeast.
Biochimica et biophysica acta.
2012 Jul; 1823(7):1208-16. doi:
10.1016/j.bbamcr.2012.04.016
. [PMID: 22575457] - Daisuke Urano, Janice C Jones, Hao Wang, Melissa Matthews, William Bradford, Jeffrey L Bennetzen, Alan M Jones. G protein activation without a GEF in the plant kingdom.
PLoS genetics.
2012 Jun; 8(6):e1002756. doi:
10.1371/journal.pgen.1002756
. [PMID: 22761582] - Sean Bulley, Michele Wright, Caius Rommens, Hua Yan, Maysoon Rassam, Kui Lin-Wang, Christelle Andre, Di Brewster, Sakuntala Karunairetnam, Andrew C Allan, William A Laing. Enhancing ascorbate in fruits and tubers through over-expression of the L-galactose pathway gene GDP-L-galactose phosphorylase.
Plant biotechnology journal.
2012 May; 10(4):390-7. doi:
10.1111/j.1467-7652.2011.00668.x
. [PMID: 22129455] - M Friederich Persson, S Franzén, S-B Catrina, G Dallner, P Hansell, K Brismar, F Palm. Coenzyme Q10 prevents GDP-sensitive mitochondrial uncoupling, glomerular hyperfiltration and proteinuria in kidneys from db/db mice as a model of type 2 diabetes.
Diabetologia.
2012 May; 55(5):1535-43. doi:
10.1007/s00125-012-2469-5
. [PMID: 22311417] - Ludwig K Groebler, Xiao Suo Wang, Hyun Bo Kim, Anu Shanu, Farjaneh Hossain, Aisling C McMahon, Paul K Witting. Cosupplementation with a synthetic, lipid-soluble polyphenol and vitamin C inhibits oxidative damage and improves vascular function yet does not inhibit acute renal injury in an animal model of rhabdomyolysis.
Free radical biology & medicine.
2012 May; 52(9):1918-28. doi:
10.1016/j.freeradbiomed.2012.02.011
. [PMID: 22343418] - Jae-Gyu Kim, Mi-Young Moon, Hee-Jun Kim, Yi Li, Dong-Keun Song, Jun-Sub Kim, Jae-Yong Lee, Jaebong Kim, Sung-Chan Kim, Jae-Bong Park. Ras-related GTPases Rap1 and RhoA collectively induce the phagocytosis of serum-opsonized zymosan particles in macrophages.
The Journal of biological chemistry.
2012 Feb; 287(7):5145-55. doi:
10.1074/jbc.m111.257634
. [PMID: 22194606] - Tal Keren-Kaplan, Ilan Attali, Khatereh Motamedchaboki, Brian A Davis, Neta Tanner, Yael Reshef, Einat Laudon, Mikhail Kolot, Olga Levin-Kravets, Oded Kleifeld, Michael Glickman, Bruce F Horazdovsky, Dieter A Wolf, Gali Prag. Synthetic biology approach to reconstituting the ubiquitylation cascade in bacteria.
The EMBO journal.
2012 Jan; 31(2):378-90. doi:
10.1038/emboj.2011.397
. [PMID: 22081111] - Adel Abramovitz, Menachem Gutman, Esther Nachliel. Structural coupling between the Rho-insert domain of Cdc42 and the geranylgeranyl binding site of RhoGDI.
Biochemistry.
2012 Jan; 51(2):715-23. doi:
10.1021/bi201211v
. [PMID: 22206343] - Malou Friederich-Persson, Shakil Aslam, Lina Nordquist, William J Welch, Christopher S Wilcox, Fredrik Palm. Acute knockdown of uncoupling protein-2 increases uncoupling via the adenine nucleotide transporter and decreases oxidative stress in diabetic kidneys.
PloS one.
2012; 7(7):e39635. doi:
10.1371/journal.pone.0039635
. [PMID: 22768304] - Dave Bridges, Louise Chang, Irfan J Lodhi, Natalie A Clark, Alan R Saltiel. TC10 is regulated by caveolin in 3T3-L1 adipocytes.
PloS one.
2012; 7(8):e42451. doi:
10.1371/journal.pone.0042451
. [PMID: 22900022] - Yuhta Nomura, Taito Takabayashi, Hiroshi Kuroda, Yasushi Yukawa, Kwanchanok Sattasuk, Mitsuru Akita, Akira Nozawa, Yuzuru Tozawa. ppGpp inhibits peptide elongation cycle of chloroplast translation system in vitro.
Plant molecular biology.
2012 Jan; 78(1-2):185-96. doi:
10.1007/s11103-011-9858-x
. [PMID: 22108865] - Peter R Huypens, Mei Huang, Jamie W Joseph. Overcoming the spatial barriers of the stimulus secretion cascade in pancreatic β-cells.
Islets.
2012 Jan; 4(1):1-116. doi:
10.4161/isl.18338
. [PMID: 22143007] - Sheng-Ying Lo, Christopher L Brett, Rachael L Plemel, Marissa Vignali, Stanley Fields, Tamir Gonen, Alexey J Merz. Intrinsic tethering activity of endosomal Rab proteins.
Nature structural & molecular biology.
2011 Dec; 19(1):40-7. doi:
10.1038/nsmb.2162
. [PMID: 22157956] - Madhu Mahankali, Hong-Juan Peng, Karen M Henkels, Mary C Dinauer, Julian Gomez-Cambronero. Phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for the GTPase Rac2.
Proceedings of the National Academy of Sciences of the United States of America.
2011 Dec; 108(49):19617-22. doi:
10.1073/pnas.1114692108
. [PMID: 22106281] - Hyun Bo Kim, Anu Shanu, Sarah Wood, Sarah N Parry, Michael Collet, Aisling McMahon, Paul K Witting. Phenolic antioxidants tert-butyl-bisphenol and vitamin E decrease oxidative stress and enhance vascular function in an animal model of rhabdomyolysis yet do not improve acute renal dysfunction.
Free radical research.
2011 Sep; 45(9):1000-12. doi:
10.3109/10715762.2011.590137
. [PMID: 21726176] - Soon-Sen Leow, Shamala Devi Sekaran, Kalyana Sundram, YewAi Tan, Ravigadevi Sambanthamurthi. Differential transcriptomic profiles effected by oil palm phenolics indicate novel health outcomes.
BMC genomics.
2011 Aug; 12(?):432. doi:
10.1186/1471-2164-12-432
. [PMID: 21864415] - Syeda H Afroze, M Nasir Uddin, Xiaobo Cao, Alexzander Asea, Dawit Gizachew. Internalization of exogenous ADP-ribosylation factor 6 (Arf6) proteins into cells.
Molecular and cellular biochemistry.
2011 Aug; 354(1-2):291-9. doi:
10.1007/s11010-011-0829-y
. [PMID: 21523371] - Marcelo J Berardi, William M Shih, Stephen C Harrison, James J Chou. Mitochondrial uncoupling protein 2 structure determined by NMR molecular fragment searching.
Nature.
2011 Jul; 476(7358):109-13. doi:
10.1038/nature10257
. [PMID: 21785437] - Hideyasu Okamura, Masaki Nishikiori, Hongyu Xiang, Masayuki Ishikawa, Etsuko Katoh. Interconversion of two GDP-bound conformations and their selection in an Arf-family small G protein.
Structure (London, England : 1993).
2011 Jul; 19(7):988-98. doi:
10.1016/j.str.2011.04.007
. [PMID: 21742265] - Raimund Tenhaken, Elena Voglas, J Mark Cock, Volker Neu, Christian G Huber. Characterization of GDP-mannose dehydrogenase from the brown alga Ectocarpus siliculosus providing the precursor for the alginate polymer.
The Journal of biological chemistry.
2011 May; 286(19):16707-15. doi:
10.1074/jbc.m111.230979
. [PMID: 21454608] - Laura García-Expósito, Jonathan Barroso-González, Isabel Puigdomènech, José-David Machado, Julià Blanco, Agustín Valenzuela-Fernández. HIV-1 requires Arf6-mediated membrane dynamics to efficiently enter and infect T lymphocytes.
Molecular biology of the cell.
2011 Apr; 22(8):1148-66. doi:
10.1091/mbc.e10-08-0722
. [PMID: 21346189] - Christopher P Vellano, Feng-Jue Shu, Suneela Ramineni, Cindee K Yates, Gregory G Tall, John R Hepler. Activation of the regulator of G protein signaling 14-Gαi1-GDP signaling complex is regulated by resistance to inhibitors of cholinesterase-8A.
Biochemistry.
2011 Feb; 50(5):752-62. doi:
10.1021/bi101910n
. [PMID: 21158412] - Katrin Weise, Shobhna Kapoor, Christian Denter, Jörg Nikolaus, Norbert Opitz, Sebastian Koch, Gemma Triola, Andreas Herrmann, Herbert Waldmann, Roland Winter. Membrane-mediated induction and sorting of K-Ras microdomain signaling platforms.
Journal of the American Chemical Society.
2011 Feb; 133(4):880-7. doi:
10.1021/ja107532q
. [PMID: 21141956]