Zytosin (BioDeep_00000868361)

Main id: BioDeep_00000400022

 

PANOMIX_OTCML-2023 BioNovoGene_Lab2019


代谢物信息卡片


InChI=1\C4H5N3O\c5-3-1-2-6-4(8)7-3\h1-2H,(H3,5,6,7,8

化学式: C4H5N3O (111.0433)
中文名称: 胞嘧啶
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C1=C(NC(=O)N=C1)N
InChI: InChI=1S/C4H5N3O/c5-3-1-2-6-4(8)7-3/h1-2H,(H3,5,6,7,8)

描述信息

COVID info from COVID-19 Disease Map
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
Cytosine is one of the four main bases found in DNA and RNA. Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging[1][2].
Cytosine is one of the four main bases found in DNA and RNA. Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging[1][2].
Cytosine is one of the four main bases found in DNA and RNA. Cytosine modifications exhibit circadian oscillations that are involved in epigenetic diversity and aging[1][2].

同义名列表

36 个代谢物同义名

InChI=1\C4H5N3O\c5-3-1-2-6-4(8)7-3\h1-2H,(H3,5,6,7,8; 4-amino-2-oxo-1,2-dihydropyrimidine; 2(1H)-Pyrimidinone, 4-amino- (9CI); 2(1H)-pyrimidinone, 6-amino-; 2(1H)-Pyrimidinone, 4-amino-; 4-Amino-2-hydroxypyrimidine; 4-aminopyrimidin-2(1H)-one; 4-Amino-2(1H)-pyrimidinone; 4-amino-3h-pyrimidin-2-one; 4-amino-2-pyrimidinol; EINECS 200-749-5; Cytosine (8CI); ZINC00895210; Cytosinimine; NCI60_012445; C3506_SIGMA; AIDS-023056; 118511-36-7; 30430_FLUKA; CHEBI:16040; AIDS023056; 14987-28-1; 26661-23-4; 66322-75-6; NSC 27787; AI3-52281; 504-05-2; NSC27787; Cytosine; Zytosin; Cytosin; 71-30-7; C00380; Cyt; Cytosine; Cytosine



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(3)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

12 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 APOBEC3A, APOBEC3G, AR, DNMT3A, FMR1, NSUN2, SP1, TET3, TRDMT1
Endoplasmic reticulum membrane 1 CD4
Nucleus 16 APOBEC3A, APOBEC3G, AR, DNMT1, DNMT3A, DNMT3B, FMR1, MBD4, NSUN2, SP1, TDG, TET1, TET2, TET3, TRDMT1, UNG
cytosol 3 APOBEC3G, AR, FMR1
dendrite 1 FMR1
nucleoplasm 13 APOBEC3A, AR, DNMT1, DNMT3A, DNMT3B, FMR1, MBD4, NSUN2, SP1, TDG, TET2, TRDMT1, UNG
Cell membrane 2 CD4, FMR1
Cell projection, axon 1 FMR1
Cell projection, growth cone 1 FMR1
Synapse 1 FMR1
Golgi membrane 1 INS
growth cone 1 FMR1
postsynapse 1 FMR1
presynaptic membrane 1 FMR1
Presynapse 1 FMR1
plasma membrane 3 AR, CD4, TDG
Membrane 2 AR, FMR1
axon 1 FMR1
extracellular exosome 1 NSUN2
extracellular space 2 INS, SP1
perinuclear region of cytoplasm 1 FMR1
mitochondrion 4 DNMT1, GATC, NSUN2, UNG
protein-containing complex 1 AR
postsynaptic density 1 FMR1
pericentric heterochromatin 1 DNMT1
Single-pass type I membrane protein 1 CD4
Secreted 2 INS, SP1
extracellular region 2 INS, SP1
external side of plasma membrane 1 CD4
dendritic spine 1 FMR1
perikaryon 1 FMR1
nucleolus 2 FMR1, NSUN2
Cytoplasm, P-body 1 APOBEC3G
P-body 2 APOBEC3A, APOBEC3G
Early endosome 1 CD4
growth cone filopodium 1 FMR1
postsynaptic membrane 1 FMR1
Cell projection, filopodium tip 1 FMR1
Cytoplasm, perinuclear region 1 FMR1
filopodium tip 1 FMR1
heterochromatin 1 DNMT3A
Membrane raft 1 CD4
Cytoplasm, cytoskeleton, spindle 1 NSUN2
spindle 1 NSUN2
Cell projection, dendritic spine 1 FMR1
PML body 1 TDG
nuclear speck 2 AR, MBD4
Postsynaptic cell membrane 1 FMR1
Cell projection, neuron projection 1 FMR1
neuron projection 1 FMR1
apolipoprotein B mRNA editing enzyme complex 1 APOBEC3G
chromatin 2 AR, SP1
cell projection 1 FMR1
Chromosome 5 DNMT3A, FMR1, TET1, TET2, TET3
cytoplasmic ribonucleoprotein granule 1 FMR1
Nucleus, nucleolus 2 FMR1, NSUN2
endosome lumen 1 INS
Chromosome, centromere 1 FMR1
female germ cell nucleus 1 DNMT1
Cell projection, dendrite 1 FMR1
Cytoplasm, Stress granule 1 FMR1
cytoplasmic stress granule 1 FMR1
euchromatin 2 DNMT3A, SP1
Presynaptic cell membrane 1 FMR1
replication fork 1 DNMT1
secretory granule lumen 1 INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 CD4, INS
nuclear matrix 1 DNMT3A
transcription repressor complex 1 SP1
axon terminus 1 FMR1
chromatoid body 1 NSUN2
XY body 1 DNMT3A
transport vesicle 1 INS
Secreted, extracellular exosome 1 NSUN2
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
chromosome, centromeric region 2 DNMT3A, FMR1
clathrin-coated endocytic vesicle membrane 1 CD4
Cajal body 1 FMR1
ribonucleoprotein complex 2 APOBEC3G, FMR1
[Isoform 2]: Nucleus 1 TET1
[Isoform 1]: Nucleus 1 TET1
Synapse, synaptosome 1 FMR1
Cytoplasm, Cytoplasmic ribonucleoprotein granule 1 FMR1
Sin3-type complex 1 TET1
protein-DNA complex 1 SP1
female pronucleus 1 TET3
male pronucleus 1 TET3
intracellular non-membrane-bounded organelle 1 FMR1
chromocenter 1 FMR1
glutamyl-tRNA(Gln) amidotransferase complex 1 GATC
neuronal ribonucleoprotein granule 1 FMR1
Nucleus, Cajal body 1 FMR1
glial cell projection 1 FMR1
T cell receptor complex 1 CD4
catalytic complex 2 DNMT3A, DNMT3B
[Isoform 6]: Cytoplasm 1 FMR1
dendritic filopodium 1 FMR1
[Isoform 9]: Cytoplasm 1 FMR1
[Isoform 10]: Nucleus 1 FMR1
[Isoform 11]: Nucleus 1 FMR1


文献列表

  • Anabella Varela, Carlos F Marfil, Sebastián Gomez Talquenca, Ariel Fontana, Sebastian Asurmendi, Fernando Buscema, Federico J Berli. Three-year study of DNA cytosine methylation dynamics in transplanted Malbec grapevines. Plant science : an international journal of experimental plant biology. 2024 May; 342(?):112037. doi: 10.1016/j.plantsci.2024.112037. [PMID: 38367820]
  • Dingbo Zhang, Vanessa Pries, Jens Boch. Targeted C•G-to-T•A base editing with TALE-cytosine deaminases in plants. BMC biology. 2024 Apr; 22(1):99. doi: 10.1186/s12915-024-01895-0. [PMID: 38679734]
  • Ying Yu, Zhijia Gu, Maokang Li, Yongfu Pu, Ariadni Geballa Koukoula, Jeroen Peters, Ying Yang, Xiaodi Hong. Cytosine-rich mismatched DNA aptamer combined with superparamagnetic photonic crystal sensing material for the specific visual detection of silver ions. Talanta. 2024 Apr; 270(?):125551. doi: 10.1016/j.talanta.2023.125551. [PMID: 38103284]
  • Rajesh Yarra, Patrick J Krysan. An SpG-Cas9-based cytosine base editor expands the scope of genome editing in carrot plants. Plant cell reports. 2024 Mar; 43(3):82. doi: 10.1007/s00299-024-03173-3. [PMID: 38441656]
  • Zongyi Yi, Xiaoxue Zhang, Wei Tang, Ying Yu, Xiaoxu Wei, Xue Zhang, Wensheng Wei. Strand-selective base editing of human mitochondrial DNA using mitoBEs. Nature biotechnology. 2024 Mar; 42(3):498-509. doi: 10.1038/s41587-023-01791-y. [PMID: 37217751]
  • Pin Cui, Xiaozhou Zhou, Shu Xu, Weihuang He, Guozeng Huang, Yong Xiong, Chuxin Zhang, Tingmin Chang, Mingji Feng, Hanming Lai, Yi Pan. Prediction of methylation status using WGS data of plasma cfDNA for multi-cancer early detection (MCED). Clinical epigenetics. 2024 02; 16(1):34. doi: 10.1186/s13148-024-01646-6. [PMID: 38414068]
  • Xiaoling Ma, Ningxin Jiang, Jingxian Fu, Yuping Li, Lijun Zhou, Ling Yuan, Ying Wang, Yongqing Li. A cytosine analogue 5-azacitidine improves the accumulation of licochalcone A in licorice Glycyrrhiza inflata. Journal of plant physiology. 2023 Nov; 292(?):154145. doi: 10.1016/j.jplph.2023.154145. [PMID: 38091890]
  • Patrick M Staunton, Andrew J Peters, Cathal Seoighe. Somatic mutations inferred from RNA-seq data highlight the contribution of replication timing to mutation rate variation in a model plant. Genetics. 2023 10; 225(2):. doi: 10.1093/genetics/iyad128. [PMID: 37450609]
  • Muhammad Arslan Mahmood. Efficient A·T-to-C·G Base Editing via Adenine Transversion Editors. Cellular reprogramming. 2023 10; 25(5):187-189. doi: 10.1089/cell.2023.0094. [PMID: 37725011]
  • Pei Liu, Xiao-Ying Tan, Huang-Qin Zhang, Ke-Lei Su, Er-Xin Shang, Qing-Ling Xiao, Sheng Guo, Jin-Ao Duan. Optimal compatibility proportional screening of Trichosanthis Pericarpium - Trichosanthis Radix and its anti - Inflammatory components effect on experimental zebrafish and coughing mice. Journal of ethnopharmacology. 2023 Aug; ?(?):117096. doi: 10.1016/j.jep.2023.117096. [PMID: 37634750]
  • Zahra Tardast, Alireza Iranbakhsh, Mostafa Ebadi, Zahra Oraghi Ardebili. Carboxylic acid-functionalized multiwalled carbon nanotubes (COOH-MWCNTs) improved production of atropine in callus of Datura inoxia by influencing metabolism, gene regulation, and DNA cytosine methylation; an in vitro biological assessment. Plant physiology and biochemistry : PPB. 2023 Aug; 202(?):107975. doi: 10.1016/j.plaphy.2023.107975. [PMID: 37634333]
  • Jiaying Huang, Qiupeng Lin, Hongyuan Fei, Zixin He, Hu Xu, Yunjia Li, Kunli Qu, Peng Han, Qiang Gao, Boshu Li, Guanwen Liu, Lixiao Zhang, Jiacheng Hu, Rui Zhang, Erwei Zuo, Yonglun Luo, Yidong Ran, Jin-Long Qiu, Kevin Tianmeng Zhao, Caixia Gao. Discovery of deaminase functions by structure-based protein clustering. Cell. 2023 07; 186(15):3182-3195.e14. doi: 10.1016/j.cell.2023.05.041. [PMID: 37379837]
  • Chen Zhang, Xue Zhong, Shaoya Li, Lei Yan, Jingying Li, Yubing He, Yong Lin, Yangjun Zhang, Lanqin Xia. Artificial evolution of OsEPSPS through an improved dual cytosine and adenine base editor generated a novel allele conferring rice glyphosate tolerance. Journal of integrative plant biology. 2023 Jul; ?(?):. doi: 10.1111/jipb.13543. [PMID: 37402157]
  • Lei Shi, Xiaona Li, Lulu Xue, Jin Zhang, Bingyan Huang, Ziqi Sun, Zhongxin Zhang, Xiaodong Dai, Suoyi Han, Wenzhao Dong, Xinyou Zhang. Creation of herbicide-resistance in allotetraploid peanut using CRISPR/Cas9-meditated cytosine base-editing. Plant biotechnology journal. 2023 Jul; ?(?):. doi: 10.1111/pbi.14114. [PMID: 37399127]
  • Zhixin Lei, Haowei Meng, Xichen Rao, Huanan Zhao, Chengqi Yi. Detect-seq, a chemical labeling and biotin pull-down approach for the unbiased and genome-wide off-target evaluation of programmable cytosine base editors. Nature protocols. 2023 07; 18(7):2221-2255. doi: 10.1038/s41596-023-00837-4. [PMID: 37277562]
  • Navneet Kaur, Swapna Nayakoti, Natasha Brock, Nigel G Halford. Uncovering plant epigenetics: new insights into cytosine methylation in rye genomes. Journal of experimental botany. 2023 06; 74(12):3395-3398. doi: 10.1093/jxb/erad144. [PMID: 37369102]
  • Baogang Wang, Binwang Cao, Zhu-Chun Bei, Likun Xu, Dongna Zhang, Liangliang Zhao, Yabin Song, Hongquan Wang. Disulfide-incorporated lipid prodrugs of cidofovir: Synthesis, antiviral activity, and release mechanism. European journal of medicinal chemistry. 2023 Jun; 258(?):115601. doi: 10.1016/j.ejmech.2023.115601. [PMID: 37390509]
  • Juan Luo, Muhammad Abid, Jing Tu, Xinxia Cai, Yi Zhang, Puxin Gao, Hongwen Huang. Cytosine base editors (CBEs) for inducing targeted DNA base editing in Nicotiana benthamiana. BMC plant biology. 2023 Jun; 23(1):305. doi: 10.1186/s12870-023-04322-8. [PMID: 37286962]
  • Mauricio Orantes-Bonilla, Hao Wang, Huey Tyng Lee, Agnieszka A Golicz, Dandan Hu, Wenwen Li, Jun Zou, Rod J Snowdon. Transgressive and parental dominant gene expression and cytosine methylation during seed development in Brassica napus hybrids. TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik. 2023 Apr; 136(5):113. doi: 10.1007/s00122-023-04345-7. [PMID: 37071201]
  • Rahul Mahadev Shelake, Dibyajyoti Pramanik, Jae-Yean Kim. Improved Dual Base Editor Systems (iACBEs) for Simultaneous Conversion of Adenine and Cytosine in the Bacterium Escherichia coli. mBio. 2023 02; 14(1):e0229622. doi: 10.1128/mbio.02296-22. [PMID: 36625577]
  • Li Mi, Ming Shi, Yu-Xuan Li, Gang Xie, Xichen Rao, Damu Wu, Aimin Cheng, Mengxiao Niu, Fengli Xu, Ying Yu, Ning Gao, Wensheng Wei, Xianhua Wang, Yangming Wang. DddA homolog search and engineering expand sequence compatibility of mitochondrial base editing. Nature communications. 2023 02; 14(1):874. doi: 10.1038/s41467-023-36600-2. [PMID: 36797253]
  • Mieun Lee, Yu Been Heo, Han Min Woo. Cytosine base editing in cyanobacteria by repressing archaic Type IV uracil-DNA glycosylase. The Plant journal : for cell and molecular biology. 2023 02; 113(3):610-625. doi: 10.1111/tpj.16074. [PMID: 36565011]
  • Shuqian Zhang, Liting Song, Bo Yuan, Cheng Zhang, Jixin Cao, Jinlong Chen, Jiayi Qiu, Yilin Tai, Jingqi Chen, Zilong Qiu, Xing-Ming Zhao, Tian-Lin Cheng. TadA reprogramming to generate potent miniature base editors with high precision. Nature communications. 2023 01; 14(1):413. doi: 10.1038/s41467-023-36004-2. [PMID: 36702845]
  • Chenhao Li, Longfei Wang, Leland J Cseke, Fernanda Vasconcelos, Jose Carlos Huguet-Tapia, Walter Gassmann, Laurens Pauwels, Frank F White, Hansong Dong, Bing Yang. Efficient CRISPR-Cas9 based cytosine base editors for phytopathogenic bacteria. Communications biology. 2023 01; 6(1):56. doi: 10.1038/s42003-023-04451-8. [PMID: 36646768]
  • Yi-Fang Chen, Yan Wang, Yue Wang, Ying-Li Luo, Zi-Dong Lu, Xiao-Jiao Du, Cong-Fei Xu, Jun Wang. Optimized Cationic Lipid-assisted Nanoparticle for Delivering CpG Oligodeoxynucleotides to Treat Hepatitis B Virus Infection. Pharmaceutical research. 2023 Jan; 40(1):145-156. doi: 10.1007/s11095-022-03307-w. [PMID: 36002611]
  • S Wang, K Ouyang. Rapid creation of CENH3-mediated haploid induction lines using a cytosine base editor (CBE). Plant biology (Stuttgart, Germany). 2023 Jan; 25(1):226-230. doi: 10.1111/plb.13482. [PMID: 36285668]
  • A Niloya Troyee, Cristian Peña-Ponton, Mónica Medrano, Koen J F Verhoeven, Conchita Alonso. Herbivory induced methylation changes in the Lombardy poplar: A comparison of results obtained by epiGBS and WGBS. PloS one. 2023; 18(9):e0291202. doi: 10.1371/journal.pone.0291202. [PMID: 37682835]
  • Ya-Ting Sabrina Chang, Ming-Ren Yen, Pao-Yang Chen. Methylome Imputation by Methylation Patterns. Methods in molecular biology (Clifton, N.J.). 2023; 2624(?):115-126. doi: 10.1007/978-1-0716-2962-8_8. [PMID: 36723812]
  • Renata Orłowska. Triticale doubled haploid plant regeneration factors linked by structural equation modeling. Journal of applied genetics. 2022 Dec; 63(4):677-690. doi: 10.1007/s13353-022-00719-7. [PMID: 36018540]
  • Waldir M Berbel-Filho, George Pacheco, Mateus G Lira, Carlos Garcia de Leaniz, Sergio M Q Lima, Carlos M Rodríguez-López, Jia Zhou, Sofia Consuegra. Additive and non-additive epigenetic signatures of natural hybridization between fish species with different mating systems. Epigenetics. 2022 12; 17(13):2356-2365. doi: 10.1080/15592294.2022.2123014. [PMID: 36082413]
  • Marandel L, Heraud C, Véron V, Laithier J, Marchand M, Quillet E, Callet T, Dupont-Nivet M, Médale F. A plant-based diet differentially affects the global hepatic methylome in rainbow trout depending on genetic background. Epigenetics. 2022 12; 17(12):1726-1737. doi: 10.1080/15592294.2022.2058226. [PMID: 35345978]
  • Lai Wong, Alina Sami, Linda Chelico. Competition for DNA binding between the genome protector replication protein A and the genome modifying APOBEC3 single-stranded DNA deaminases. Nucleic acids research. 2022 11; 50(21):12039-12057. doi: 10.1093/nar/gkac1121. [PMID: 36444883]
  • Xiao-Cong Zhao, Hai-Long Dong, Xiao-Lu Li, Hong-Yu Yang, Xue-Feng Chen, Liang Dai, Wen-Qiang Wu, Zhi-Jie Tan, Xing-Hua Zhang. 5-Methyl-cytosine stabilizes DNA but hinders DNA hybridization revealed by magnetic tweezers and simulations. Nucleic acids research. 2022 11; 50(21):12344-12354. doi: 10.1093/nar/gkac1122. [PMID: 36477372]
  • Hongzhi Wang, Yuxin He, Yingying Wang, Zuren Li, Jiannan Hao, Yijiao Song, Mugui Wang, Jian-Kang Zhu. Base editing-mediated targeted evolution of ACCase for herbicide-resistant rice mutants. Journal of integrative plant biology. 2022 Nov; 64(11):2029-2032. doi: 10.1111/jipb.13352. [PMID: 36036619]
  • Guilian Xiao, Junzhi Zhou, Zhiheng Huo, Tong Wu, Yingchun Li, Yajing Li, Yanxia Wang, Mengcheng Wang. The Shift in Synonymous Codon Usage Reveals Similar Genomic Variation during Domestication of Asian and African Rice. International journal of molecular sciences. 2022 Oct; 23(21):. doi: 10.3390/ijms232112860. [PMID: 36361651]
  • Mauricio Peñuela, Jenny Johana Gallo-Franco, Jorge Finke, Camilo Rocha, Anestis Gkanogiannis, Thaura Ghneim-Herrera, Mathias Lorieux. Methylation in the CHH Context Allows to Predict Recombination in Rice. International journal of molecular sciences. 2022 Oct; 23(20):. doi: 10.3390/ijms232012505. [PMID: 36293364]
  • Kumari Alka, Ghulam Mohammad, Renu A Kowluru. Regulation of serine palmitoyl-transferase and Rac1-Nox2 signaling in diabetic retinopathy. Scientific reports. 2022 10; 12(1):16740. doi: 10.1038/s41598-022-20243-2. [PMID: 36202842]
  • Jia-Yi Lin, Way-Rong Lin, I-Son Ng. CRISPRa/i with Adaptive Single Guide Assisted Regulation DNA (ASGARD) mediated control of Chlorella sorokiniana to enhance lipid and protein production. Biotechnology journal. 2022 Oct; 17(10):e2100514. doi: 10.1002/biot.202100514. [PMID: 34800080]
  • Daniela Strenkert, Asli Yildirim, Juying Yan, Yuko Yoshinaga, Matteo Pellegrini, Ronan C O'Malley, Sabeeha S Merchant, James G Umen. The landscape of Chlamydomonas histone H3 lysine 4 methylation reveals both constant features and dynamic changes during the diurnal cycle. The Plant journal : for cell and molecular biology. 2022 10; 112(2):352-368. doi: 10.1111/tpj.15948. [PMID: 35986497]
  • Tslil Gabrieli, Yael Michaeli, Sigal Avraham, Dmitry Torchinsky, Sapir Margalit, Leonie Schütz, Matyas Juhasz, Ceyda Coruh, Nissim Arbib, Zhaohui Sunny Zhou, Julie A Law, Elmar Weinhold, Yuval Ebenstein. Chemoenzymatic labeling of DNA methylation patterns for single-molecule epigenetic mapping. Nucleic acids research. 2022 09; 50(16):e92. doi: 10.1093/nar/gkac460. [PMID: 35657088]
  • Chenchen Ma, Peng Liu, Siyuan Cui, Chang Gao, Xing Tan, Zhaopeng Liu, Ruirong Xu. The Identification of APOBEC3G as a Potential Prognostic Biomarker in Acute Myeloid Leukemia and a Possible Drug Target for Crotonoside. Molecules (Basel, Switzerland). 2022 Sep; 27(18):. doi: 10.3390/molecules27185804. [PMID: 36144542]
  • Martin Bitomský, Lucie Kobrlová, Michal Hroneš, Jitka Klimešová, Martin Duchoslav. Stoichiometry versus ecology: the relationships between genome size and guanine-cytosine content, and tissue nitrogen and phosphorus in grassland herbs. Annals of botany. 2022 09; 130(2):189-197. doi: 10.1093/aob/mcac079. [PMID: 35700050]
  • Andrej Sečnik, Nataša Štajner, Sebastjan Radišek, Urban Kunej, Mitja Križman, Jernej Jakše. Cytosine Methylation in Genomic DNA and Characterization of DNA Methylases and Demethylases and Their Expression Profiles in Viroid-Infected Hop Plants (Humulus lupulus Var. 'Celeia'). Cells. 2022 08; 11(16):. doi: 10.3390/cells11162592. [PMID: 36010668]
  • Yulin Zheng, Yunlei Zhou, Xiaoting Cui, Hengming Yan, Lulu Cao, Lanlan Gao, Huanshun Yin. Investigation of the effect of antibiotics on 5-formylcytosine content in mazie seedling tissues based on photoelectrochemical biosensor. Journal of hazardous materials. 2022 08; 436(?):129146. doi: 10.1016/j.jhazmat.2022.129146. [PMID: 35594676]
  • Hardik Kundariya, Robersy Sanchez, Xiaodong Yang, Alenka Hafner, Sally A Mackenzie. Methylome decoding of RdDM-mediated reprogramming effects in the Arabidopsis MSH1 system. Genome biology. 2022 08; 23(1):167. doi: 10.1186/s13059-022-02731-w. [PMID: 35927734]
  • Sreejith Jayasree Varma, Enrica Calvani, Nana-Maria Grüning, Christoph B Messner, Nicholas Grayson, Floriana Capuano, Michael Mülleder, Markus Ralser. Global analysis of cytosine and adenine DNA modifications across the tree of life. eLife. 2022 07; 11(?):. doi: 10.7554/elife.81002. [PMID: 35900202]
  • Tomoyuki Otsuka, Sumiyuki Nishida, Takayuki Shibahara, Burcu Temizoz, Masanari Hamaguchi, Takayuki Shiroyama, Keiko Kimura, Kotaro Miyake, Haruhiko Hirata, Yumiko Mizuno, Mayu Yagita, Yusuke Manabe, Etsushi Kuroda, Yoshito Takeda, Hiroshi Kida, Ken J Ishii, Atsushi Kumanogoh. CpG ODN (K3)-toll-like receptor 9 agonist-induces Th1-type immune response and enhances cytotoxic activity in advanced lung cancer patients: a phase I study. BMC cancer. 2022 Jul; 22(1):744. doi: 10.1186/s12885-022-09818-4. [PMID: 35799134]
  • Zhixin Lei, Haowei Meng, Lulu Liu, Huanan Zhao, Xichen Rao, Yongchang Yan, Hao Wu, Min Liu, Aibin He, Chengqi Yi. Mitochondrial base editor induces substantial nuclear off-target mutations. Nature. 2022 06; 606(7915):804-811. doi: 10.1038/s41586-022-04836-5. [PMID: 35551512]
  • Fernanda Silva Coelho, Sara Sangi, Juliana Lopes Moraes, Walaci da Silva Santos, Eduardo Alves Gamosa, Kátia Valevski Sales Fernandes, Clícia Grativol. Methyl-CpG binding proteins (MBD) family evolution and conservation in plants. Gene. 2022 May; 824(?):146404. doi: 10.1016/j.gene.2022.146404. [PMID: 35278634]
  • Xiangyu Xiong, Zhenxiang Li, Jieping Liang, Kehui Liu, Chenlong Li, Jian-Feng Li. A cytosine base editor toolkit with varying activity windows and target scopes for versatile gene manipulation in plants. Nucleic acids research. 2022 04; 50(6):3565-3580. doi: 10.1093/nar/gkac166. [PMID: 35286371]
  • Xing Ma, Yilong Feng, Ying Yang, Xin Li, Yining Shi, Shentong Tao, Xuejiao Cheng, Jian Huang, Xiu-E Wang, Caiyan Chen, David Monchaud, Wenli Zhang. Genome-wide characterization of i-motifs and their potential roles in the stability and evolution of transposable elements in rice. Nucleic acids research. 2022 04; 50(6):3226-3238. doi: 10.1093/nar/gkac121. [PMID: 35188565]
  • Michael S Packer, Vivek Chowdhary, Genesis Lung, Lo-I Cheng, Yvonne Aratyn-Schaus, Dominique Leboeuf, Sarah Smith, Aalok Shah, Delai Chen, Marina Zieger, Brian J Cafferty, Bo Yan, Giuseppe Ciaramella, Francine M Gregoire, Christian Mueller. Evaluation of cytosine base editing and adenine base editing as a potential treatment for alpha-1 antitrypsin deficiency. Molecular therapy : the journal of the American Society of Gene Therapy. 2022 04; 30(4):1396-1406. doi: 10.1016/j.ymthe.2022.01.040. [PMID: 35121111]
  • Yuechao Wu, Yao He, Simon Sretenovic, Shishi Liu, Yanhao Cheng, Yangshuo Han, Guanqing Liu, Yu Bao, Qing Fang, Xuelian Zheng, Jianping Zhou, Yiping Qi, Yong Zhang, Tao Zhang. CRISPR-BETS: a base-editing design tool for generating stop codons. Plant biotechnology journal. 2022 Mar; 20(3):499-510. doi: 10.1111/pbi.13732. [PMID: 34669232]
  • Nozomu Hanaoka, Masatoshi Hazama, Koji Fukushima, Tsuguto Fujimoto. Sensitivity of Human Mastadenovirus, the Causal Agent of Pharyngoconjunctival Fever, Epidemic Keratoconjunctivitis, and Hemorrhagic Cystitis in Immunocompromised Individuals, to Brincidofovir. Microbiology spectrum. 2022 02; 10(1):e0156921. doi: 10.1128/spectrum.01569-21. [PMID: 35171015]
  • Zhiquan Liu, Siyu Chen, Liangxue Lai, Zhanjun Li. Inhibition of base editors with anti-deaminases derived from viruses. Nature communications. 2022 02; 13(1):597. doi: 10.1038/s41467-022-28300-0. [PMID: 35105899]
  • Felipe H Moura, Arturo Macias-Franco, Camilo A Pena-Bello, Evandro C Archilia, Isadora M Batalha, Aghata E M Silva, Gabriel M Moreira, Aaron B Norris, Luis F Schütz, Mozart A Fonseca. Sperm DNA 5-methyl cytosine and RNA N6-methyladenosine methylation are differently affected during periods of body weight losses and body weight gain of young and mature breeding bulls. Journal of animal science. 2022 Feb; 100(2):. doi: 10.1093/jas/skab362. [PMID: 34902028]
  • Sitian He, Songcheng Yu, Yinhua Feng, Leiliang He, Lie Liu, Clement Yaw Effah, Yongjun Wu. A digital immuno-PCR assay for simultaneous determination of 5-methylcytosine and 5-hydroxymethylcytosine in human serum. Analytica chimica acta. 2022 Feb; 1192(?):339321. doi: 10.1016/j.aca.2021.339321. [PMID: 35057947]
  • Shuai Wang, Hairong Xie, Fei Mao, Haiyan Wang, Shu Wang, Zhenglin Chen, Yuxia Zhang, Zhihui Xu, Jinming Xing, Zhaokang Cui, Xiquan Gao, Hongmei Jin, Jian Hua, Bo Xiong, Yufeng Wu. N4-acetyldeoxycytosine DNA modification marks euchromatin regions in Arabidopsis thaliana. Genome biology. 2022 01; 23(1):5. doi: 10.1186/s13059-021-02578-7. [PMID: 34980211]
  • HueyTyng Lee. Analysis of Bisulfite Sequencing Data Using Bismark and DMRcaller to Identify Differentially Methylated Regions. Methods in molecular biology (Clifton, N.J.). 2022; 2443(?):451-463. doi: 10.1007/978-1-0716-2067-0_23. [PMID: 35037220]
  • Zhi-Hong Liu, Shanjie Tang, Wentao Hu, Ruo Lv, Hailiang Mei, Rongxin Yang, Xianwei Song, Xiaofeng Cao, Dong Wang. Precise editing of methylated cytosine in Arabidopsis thaliana using a human APOBEC3Bctd-Cas9 fusion. Science China. Life sciences. 2022 01; 65(1):219-222. doi: 10.1007/s11427-021-1970-x. [PMID: 34406570]
  • Abere Habtamu Manayia, Fasih Bintang Ilhami, Ai-Wei Lee, Chih-Chia Cheng. Photoreactive Cytosine-Functionalized Self-Assembled Micelles with Enhanced Cellular Uptake Capability for Efficient Cancer Chemotherapy. Biomacromolecules. 2021 12; 22(12):5307-5318. doi: 10.1021/acs.biomac.1c01199. [PMID: 34802236]
  • Ping Xu, Zhiheng Liu, Ying Liu, Huazheng Ma, Yiyuan Xu, Ying Bao, Shiyou Zhu, Zhongzheng Cao, Zeguang Wu, Zhuo Zhou, Wensheng Wei. Genome-wide interrogation of gene functions through base editor screens empowered by barcoded sgRNAs. Nature biotechnology. 2021 11; 39(11):1403-1413. doi: 10.1038/s41587-021-00944-1. [PMID: 34155407]
  • Scott Parker, June D'Angelo, R Mark Buller, Donald F Smee, Johan Lantto, Henriette Nielsen, Allan Jensen, Mark Prichard, Sarah L George. A human recombinant analogue to plasma-derived vaccinia immunoglobulin prophylactically and therapeutically protects against lethal orthopoxvirus challenge. Antiviral research. 2021 11; 195(?):105179. doi: 10.1016/j.antiviral.2021.105179. [PMID: 34530009]
  • Peng Tian, Zeteng Lin, Dongbo Lin, Shuangyu Dong, Jianzi Huang, Tengbo Huang. The pattern of DNA methylation alteration, and its association with the changes of gene expression and alternative splicing during phosphate starvation in tomato. The Plant journal : for cell and molecular biology. 2021 11; 108(3):841-858. doi: 10.1111/tpj.15486. [PMID: 34492142]
  • Peng Ni, Neng Huang, Fan Nie, Jun Zhang, Zhi Zhang, Bo Wu, Lu Bai, Wende Liu, Chuan-Le Xiao, Feng Luo, Jianxin Wang. Genome-wide detection of cytosine methylations in plant from Nanopore data using deep learning. Nature communications. 2021 10; 12(1):5976. doi: 10.1038/s41467-021-26278-9. [PMID: 34645826]
  • Rui Zhang, Sha Chen, Xiangbing Meng, Zhuangzhuang Chai, Delin Wang, Yuge Yuan, Kunling Chen, Linjian Jiang, Jiayang Li, Caixia Gao. Generating broad-spectrum tolerance to ALS-inhibiting herbicides in rice by base editing. Science China. Life sciences. 2021 Oct; 64(10):1624-1633. doi: 10.1007/s11427-020-1800-5. [PMID: 33165814]
  • Qiurong Ren, Simon Sretenovic, Guanqing Liu, Zhaohui Zhong, Jiaheng Wang, Lan Huang, Xu Tang, Yachong Guo, Li Liu, Yuechao Wu, Jie Zhou, Yuxin Zhao, Han Yang, Yao He, Shishi Liu, Desuo Yin, Rocio Mayorga, Xuelian Zheng, Tao Zhang, Yiping Qi, Yong Zhang. Improved plant cytosine base editors with high editing activity, purity, and specificity. Plant biotechnology journal. 2021 10; 19(10):2052-2068. doi: 10.1111/pbi.13635. [PMID: 34042262]
  • Jianyong Wang, Yujing Lin, Mengli Xi. Analysis of Codon Usage Patterns of Six Sequenced Brachypodium distachyon Lines Reveals a Declining CG Skew of the CDSs from the 5'-ends to the 3'-ends. Genes. 2021 09; 12(10):. doi: 10.3390/genes12101467. [PMID: 34680862]
  • Xiaoqi Yang, Xiuliang Wang, Jianting Yao, Delin Duan. Genome-Wide Mapping of Cytosine Methylation Revealed Dynamic DNA Methylation Patterns Associated with Sporophyte Development of Saccharina japonica. International journal of molecular sciences. 2021 Sep; 22(18):. doi: 10.3390/ijms22189877. [PMID: 34576045]
  • Riqing Li, Si Nian Char, Bo Liu, Hua Liu, Xianran Li, Bing Yang. High-efficiency plastome base editing in rice with TAL cytosine deaminase. Molecular plant. 2021 09; 14(9):1412-1414. doi: 10.1016/j.molp.2021.07.007. [PMID: 34265443]
  • Linnell Bentley Randall, Simon Sretenovic, Yuechao Wu, Desuo Yin, Tao Zhang, Joyce Van Eck, Yiping Qi. Genome- and transcriptome-wide off-target analyses of an improved cytosine base editor. Plant physiology. 2021 09; 187(1):73-87. doi: 10.1093/plphys/kiab264. [PMID: 34618139]
  • Ioannis Konstantinidis, Dafni Anastasiadi, Pål Sætrom, Artem V Nedoluzhko, Robin Mjelle, Tomasz Podgorniak, Francesc Piferrer, Jorge M O Fernandes. Epigenetic mapping of the somatotropic axis in Nile tilapia reveals differential DNA hydroxymethylation marks associated with growth. Genomics. 2021 09; 113(5):2953-2964. doi: 10.1016/j.ygeno.2021.06.037. [PMID: 34214627]
  • Ahmed M Ramadan, Afnan A Alnufaei, Thana K Khan, Hani M Ali, Hala F Eissa, Sabah M Hassan. The first report of RNA U to C or G editing in the mitochondrial NADH dehydrogenase subunit 5 (Nad5) transcript of wild barley. Molecular biology reports. 2021 Aug; 48(8):6057-6064. doi: 10.1007/s11033-021-06609-1. [PMID: 34374896]
  • Xuehuan Dai, Jing Wang, Yuguang Song, Zhenhua Liu, Tao Xue, Meng Qiao, Yanchong Yu, Wei Xin, Fengning Xiang. Cytosine methylation of the FWA promoter promotes direct in vitro shoot regeneration in Arabidopsis thaliana. Journal of integrative plant biology. 2021 Aug; 63(8):1491-1504. doi: 10.1111/jipb.13156. [PMID: 34292662]
  • Mukhtar Sadykov, Tobias Mourier, Qingtian Guan, Arnab Pain. Short sequence motif dynamics in the SARS-CoV-2 genome suggest a role for cytosine deamination in CpG reduction. Journal of molecular cell biology. 2021 07; 13(3):225-227. doi: 10.1093/jmcb/mjab011. [PMID: 33630074]
  • Aline Muyle, Jeffrey Ross-Ibarra, Danelle K Seymour, Brandon S Gaut. Gene body methylation is under selection in Arabidopsis thaliana. Genetics. 2021 06; 218(2):. doi: 10.1093/genetics/iyab061. [PMID: 33871638]
  • Zhenning Yu, Si-Yang Liu, Yanfei Zhang, Yunda Li, Yuzhi Xu, Danping Chen, Zong Dai, Xiaoyong Zou. Pearl Necklacelike Strategy Enables Quantification of Global 5-Hydroxymethylcytosine and 5-Formylcytosine by Inductively Coupled Plasma-Atomic Emission Spectrometry. Analytical chemistry. 2021 06; 93(22):7787-7791. doi: 10.1021/acs.analchem.1c01548. [PMID: 34037387]
  • Zhixin Lei, Haowei Meng, Zhicong Lv, Menghao Liu, Huanan Zhao, Hao Wu, Xiaoxue Zhang, Lulu Liu, Yuan Zhuang, Kailin Yin, Yongchang Yan, Chengqi Yi. Detect-seq reveals out-of-protospacer editing and target-strand editing by cytosine base editors. Nature methods. 2021 06; 18(6):643-651. doi: 10.1038/s41592-021-01172-w. [PMID: 34099937]
  • Bryan B Guzman, Amanda P Schauer, John A Dunn, Mackenzie L Cottrell, Craig Sykes. A quantitative LC-MS/MS method for the determination of tissue brincidofovir and cidofovir diphosphate in a MuPyV-infected mouse model. Biomedical chromatography : BMC. 2021 May; 35(5):e5061. doi: 10.1002/bmc.5061. [PMID: 33398885]
  • Tom Baladi, Jesper R Nilsson, Audrey Gallud, Emanuele Celauro, Cécile Gasse, Fabienne Levi-Acobas, Ivo Sarac, Marcel R Hollenstein, Anders Dahlén, Elin K Esbjörner, L Marcus Wilhelmsson. Stealth Fluorescence Labeling for Live Microscopy Imaging of mRNA Delivery. Journal of the American Chemical Society. 2021 04; 143(14):5413-5424. doi: 10.1021/jacs.1c00014. [PMID: 33797236]
  • Linhong Teng, Wentao Han, Xiao Fan, Xiaowen Zhang, Dong Xu, Yitao Wang, Sadequr Rahman, Matteo Pellegrini, Thomas Mock, Naihao Ye. Integrative analysis of chloroplast DNA methylation in a marine alga-Saccharina japonica. Plant molecular biology. 2021 Apr; 105(6):611-623. doi: 10.1007/s11103-020-01113-9. [PMID: 33528753]
  • Sebastian M Siegner, Mehmet E Karasu, Markus S Schröder, Zacharias Kontarakis, Jacob E Corn. PnB Designer: a web application to design prime and base editor guide RNAs for animals and plants. BMC bioinformatics. 2021 Mar; 22(1):101. doi: 10.1186/s12859-021-04034-6. [PMID: 33653259]
  • Ian Vandenbussche, Andrea Sass, Filip Van Nieuwerburgh, Marta Pinto-Carbó, Olga Mannweiler, Leo Eberl, Tom Coenye. Detection of cytosine methylation in Burkholderia cenocepacia by single-molecule real-time sequencing and whole-genome bisulfite sequencing. Microbiology (Reading, England). 2021 03; 167(3):. doi: 10.1099/mic.0.001027. [PMID: 33565960]
  • Zafer Sahin, Sevde Nur Biltekin, Leyla Yurttas, Barkin Berk, Yağmur Özhan, Hande Sipahi, Zhan-Guo Gao, Kenneth A Jacobson, Şeref Demirayak. Novel cyanothiouracil and cyanothiocytosine derivatives as concentration-dependent selective inhibitors of U87MG glioblastomas: Adenosine receptor binding and potent PDE4 inhibition. European journal of medicinal chemistry. 2021 Feb; 212(?):113125. doi: 10.1016/j.ejmech.2020.113125. [PMID: 33422981]
  • Filipe Borges, Mark T A Donoghue, Chantal LeBlanc, Emily E Wear, Milos Tanurdžić, Benjamin Berube, Ashley Brooks, William F Thompson, Linda Hanley-Bowdoin, Robert A Martienssen. Loss of Small-RNA-Directed DNA Methylation in the Plant Cell Cycle Promotes Germline Reprogramming and Somaclonal Variation. Current biology : CB. 2021 02; 31(3):591-600.e4. doi: 10.1016/j.cub.2020.10.098. [PMID: 33275892]
  • Christina L Hutson, Ashley V Kondas, Mathew R Mauldin, Jeffrey B Doty, Irma M Grossi, Clint N Morgan, Sharon Dietz Ostergaard, Christine M Hughes, Yoshinori Nakazawa, Chantal Kling, Brock E Martin, James A Ellison, Darin S Carroll, Nadia F Gallardo-Romero, Victoria A Olson. Pharmacokinetics and Efficacy of a Potential Smallpox Therapeutic, Brincidofovir, in a Lethal Monkeypox Virus Animal Model. mSphere. 2021 02; 6(1):. doi: 10.1128/msphere.00927-20. [PMID: 33536322]
  • Yunlong Lu, Yunyun Song, Lingtong Liu, Tai Wang. DNA methylation dynamics of sperm cell lineage development in tomato. The Plant journal : for cell and molecular biology. 2021 02; 105(3):565-579. doi: 10.1111/tpj.15098. [PMID: 33249677]
  • Klára Konečná, Pavla Polanská Sováková, Karin Anteková, Jiří Fajkus, Miloslava Fojtová. Distinct Responses of Arabidopsis Telomeres and Transposable Elements to Zebularine Exposure. International journal of molecular sciences. 2021 Jan; 22(1):. doi: 10.3390/ijms22010468. [PMID: 33466545]
  • Silvia Eckert, Jasmin Herden, Marc Stift, Jasmin Joshi, Mark van Kleunen. Manipulation of cytosine methylation does not remove latitudinal clines in two invasive goldenrod species in Central Europe. Molecular ecology. 2021 01; 30(1):222-236. doi: 10.1111/mec.15722. [PMID: 33150604]
  • Marco Catoni, Nicolae Radu Zabet. Analysis of Plant DNA Methylation Profiles Using R. Methods in molecular biology (Clifton, N.J.). 2021; 2250(?):219-238. doi: 10.1007/978-1-0716-1134-0_21. [PMID: 33900608]
  • Marcos Viejo, Igor Yakovlev, Carl Gunnar Fossdal. Immunochemical Detection of Modified Species of Cytosine in Plant Tissues. Methods in molecular biology (Clifton, N.J.). 2021; 2198(?):209-216. doi: 10.1007/978-1-0716-0876-0_17. [PMID: 32822034]
  • Zhihua Ou, Christos Ouzounis, Daxi Wang, Wanying Sun, Junhua Li, Weijun Chen, Philippe Marlière, Antoine Danchin. A Path toward SARS-CoV-2 Attenuation: Metabolic Pressure on CTP Synthesis Rules the Virus Evolution. Genome biology and evolution. 2020 12; 12(12):2467-2485. doi: 10.1093/gbe/evaa229. [PMID: 33125064]
  • Kutubuddin A Molla, Yiping Qi, Subhasis Karmakar, Mirza J Baig. Base Editing Landscape Extends to Perform Transversion Mutation. Trends in genetics : TIG. 2020 12; 36(12):899-901. doi: 10.1016/j.tig.2020.09.001. [PMID: 32951947]
  • Fang Liu, Weishu Fan, Jun-Bo Yang, Chun-Lei Xiang, Jeffrey P Mower, De-Zhu Li, Andan Zhu. Episodic and guanine-cytosine-biased bursts of intragenomic and interspecific synonymous divergence in Ajugoideae (Lamiaceae) mitogenomes. The New phytologist. 2020 11; 228(3):1107-1114. doi: 10.1111/nph.16753. [PMID: 32558926]
  • Jackson Londeree, Pamela D Winterberg, Rouba Garro, Roshan P George, Stella Shin, Rochelle Liverman, Anastacia Serluco, Rene Romero, Inci Yildirim. Brincidofovir for the treatment of human adenovirus infection in pediatric solid organ transplant recipients: A case series. Pediatric transplantation. 2020 11; 24(7):e13769. doi: 10.1111/petr.13769. [PMID: 32558134]
  • Marta Malinowska, Istvan Nagy, Cornelis A M Wagemaker, Anja K Ruud, Simon F Svane, Kristian Thorup-Kristensen, Christian S Jensen, Birger Eriksen, Lene Krusell, Ahmed Jahoor, Jens Jensen, Lars Bonde Eriksen, Torben Asp. The cytosine methylation landscape of spring barley revealed by a new reduced representation bisulfite sequencing pipeline, WellMeth. The plant genome. 2020 11; 13(3):e20049. doi: 10.1002/tpg2.20049. [PMID: 33217208]
  • H Blasco, C Bessy, L Plantier, A Lefevre, E Piver, L Bernard, J Marlet, K Stefic, Isabelle Benz-de Bretagne, P Cannet, H Lumbu, T Morel, P Boulard, C R Andres, P Vourc'h, O Hérault, A Guillon, P Emond. The specific metabolome profiling of patients infected by SARS-COV-2 supports the key role of tryptophan-nicotinamide pathway and cytosine metabolism. Scientific reports. 2020 10; 10(1):16824. doi: 10.1038/s41598-020-73966-5. [PMID: 33033346]
  • Piero Lovreglio, Angela Stufano, Roberta Andreoli, Cesare Tomasi, Paola Cagnazzi, Anna Barbieri, Leonardo Soleo, Giuseppe De Palma. Urinary biomarkers of nucleic acid oxidation and methylation in workers exposed to low concentrations of benzene. Toxicology letters. 2020 Oct; 331(?):235-241. doi: 10.1016/j.toxlet.2020.06.010. [PMID: 32562636]
  • Lukas Bokelmann, Isabelle Glocke, Matthias Meyer. Reconstructing double-stranded DNA fragments on a single-molecule level reveals patterns of degradation in ancient samples. Genome research. 2020 10; 30(10):1449-1457. doi: 10.1101/gr.263863.120. [PMID: 32963029]