Prasterone (BioDeep_00000422634)
Main id: BioDeep_00000001231
natural product PANOMIX_OTCML-2023 BioNovoGene_Lab2019
代谢物信息卡片
Dehydroepiandrosterone
化学式: C19H28O2 (288.2089)
中文名称: 去氢表雄酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC12CCC3C(C1CCC2=O)CC=C4C3(CCC(C4)O)C
InChI: InChI=1S/C19H28O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h3,13-16,20H,4-11H2,1-2H3/t13-,14-,15-,16-,18-,19-/m0/s1
描述信息
A - Alimentary tract and metabolism > A14 - Anabolic agents for systemic use > A14A - Anabolic steroids > A14AA - Androstan derivatives
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
D007155 - Immunologic Factors
同义名列表
3 个代谢物同义名
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:28689
- KEGG: C01227
- KEGGdrug: D08409
- PubChem: 5881
- DrugBank: DB01708
- ChEMBL: CHEMBL90593
- MeSH: Dehydroepiandrosterone
- CAS: 105597-37-3
- CAS: 53-43-0
- MoNA: Bruker_HCD_library001771
- PubChem: 4449
- LipidMAPS: LMST02020021
- PDB-CCD: AND
- 3DMET: B01415
- NIKKAJI: J4.147E
- BioNovoGene_Lab2019: BioNovoGene_Lab2019-934
- KNApSAcK: 28689
分类词条
相关代谢途径
Reactome(7)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
2 个相关的物种来源信息
- 9606 - Homo sapiens:
- 1827580 - Streptomyces nigra: 10.3389/FMICB.2018.01587
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Ying Liu, Feng Ni, Jing Huang, Yuqin Hu, Jing Wang, Xuemei Wang, Xin Du, Hong Jiang. PPAR-α inhibits DHEA-induced ferroptosis in granulosa cells through upregulation of FADS2.
Biochemical and biophysical research communications.
2024 Jun; 715(?):150005. doi:
10.1016/j.bbrc.2024.150005. [PMID: 38678785] - Shaojing He, Hui Li, Qianjie Zhang, Weimin Zhao, Wei Li, Chaohui Dai, Bixia Li, Jinhua Cheng, Shuang Wu, Zhongming Zhou, Jing Yang, Saijiao Li. Berberine alleviates inflammation in polycystic ovary syndrome by inhibiting hyaluronan synthase 2 expression.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2024 Jun; 128(?):155456. doi:
10.1016/j.phymed.2024.155456. [PMID: 38537446] - Yuanyuan Chen, Zhaohua Liu, Hongmei Chen, Yi Wen, Lang Fan, Man Luo. Rhythm gene PER1 mediates ferroptosis and lipid metabolism through SREBF2/ALOX15 axis in polycystic ovary syndrome.
Biochimica et biophysica acta. Molecular basis of disease.
2024 Jun; 1870(5):167182. doi:
10.1016/j.bbadis.2024.167182. [PMID: 38653359] - Peiwei Cong, Bing Shang, Lina Zhang, Zhaoli Wu, Yanan Wang, Jia Li, Lin Zhang. New insights into the treatment of polycystic ovary syndrome: HKDC1 promotes the growth of ovarian granulocyte cells by regulating mitochondrial function and glycolysis.
Journal of molecular histology.
2024 Apr; 55(2):187-199. doi:
10.1007/s10735-024-10183-8. [PMID: 38478190] - Ruiyun Li, Rui Hu, Yi Huang, Dan Li, Xiaoling Ma, Yuan Yang. Astragalus polysaccharide alleviates polycystic ovary syndrome by reducing insulin resistance and oxidative stress and increasing the diversity of gut microbiota.
Endocrine.
2024 Mar; 83(3):783-797. doi:
10.1007/s12020-023-03553-x. [PMID: 37824046] - Yong Lin, Huiling Zeng, Jieying Lin, Yiwei Peng, Xueyun Que, Lijun Wang, Ling Chen, Ni Bai. Evaluating the therapeutic potential of moxibustion on polycystic ovary syndrome: a rat model study on gut microbiota and metabolite interaction.
Frontiers in cellular and infection microbiology.
2024; 14(?):1328741. doi:
10.3389/fcimb.2024.1328741. [PMID: 38665877] - Yongju Ye, Weimei Zhou, Yuefang Ren, Jiali Lu, Aixue Chen, Ruiying Jin, Feilan Xuan. The ameliorating effects of Guizhi Fuling Wan combined with rosiglitazone in a rat ovarian model of polycystic ovary syndrome by the PI3K/AKT/NF-κB and Nrf2/HO-1 pathways.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2023 Dec; 39(1):2254848. doi:
10.1080/09513590.2023.2254848. [PMID: 37706434] - Tingting Zhang, Huimin Gao, Yali Fan, Shuya Chen, Yingying Li, Ruixia Liu, Tianhe Li, Chenghong Yin. Gut microbiota disorder induces liver dysfunction in polycystic ovary syndrome rats' model by regulating metabolite rosmarinic acid.
Life sciences.
2023 Oct; 330(?):121912. doi:
10.1016/j.lfs.2023.121912. [PMID: 37423380] - Yi-Fen Chiang, I-Cheng Lin, Ko-Chieh Huang, Hsin-Yuan Chen, Mohamed Ali, Yun-Ju Huang, Shih-Min Hsia. Caffeic acid's role in mitigating polycystic ovary syndrome by countering apoptosis and ER stress triggered by oxidative stress.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Oct; 166(?):115327. doi:
10.1016/j.biopha.2023.115327. [PMID: 37619480] - Mengqing Gu, Han Cai, Weinan Deng, Yedong Tang, Shuailin Du, Peiran Wang, Wenbo Deng, Haibin Wang, Aijun Sun, Shuangbo Kong. Dingkun pill alleviates metabolic abnormalities in polycystic ovary syndrome through brown adipose tissue activation.
Journal of ovarian research.
2023 Aug; 16(1):176. doi:
10.1186/s13048-023-01215-0. [PMID: 37633943] - Fengya Zhu, Shao Yin, Bin Yang, Siyun Li, Xia Feng, Tianyu Wang, Deya Che. TEAS, DHEA, CoQ10, and GH for poor ovarian response undergoing IVF-ET: a systematic review and network meta-analysis.
Reproductive biology and endocrinology : RB&E.
2023 Jul; 21(1):64. doi:
10.1186/s12958-023-01119-0. [PMID: 37464357] - Rama Satya Sri Kotipalli, Samata Sai Patnaik, Jerald Mahesh Kumar, Sistla Ramakrishna, Kathirvel Muralidharan. Biochanin-A attenuates DHEA-induced polycystic ovary syndrome via upregulation of GDF9 and BMP15 signaling in vivo.
Life sciences.
2023 May; 326(?):121795. doi:
10.1016/j.lfs.2023.121795. [PMID: 37230376] - Jing Wang, Xinyao Pan, Jing Zhou, Xin Li, Yan Sun, Ling Wang. Advances in understanding the effect and mechanism of dehydroepiandrosterone on diminished ovarian reserve.
Drug discoveries & therapeutics.
2023 May; 17(2):87-94. doi:
10.5582/ddt.2022.01109. [PMID: 37019659] - Adam Yasgar, Danielle Bougie, Richard T Eastman, Ruili Huang, Misha Itkin, Jennifer Kouznetsova, Caitlin Lynch, Crystal McKnight, Mitch Miller, Deborah K Ngan, Tyler Peryea, Pranav Shah, Paul Shinn, Menghang Xia, Xin Xu, Alexey V Zakharov, Anton Simeonov. Quantitative Bioactivity Signatures of Dietary Supplements and Natural Products.
ACS pharmacology & translational science.
2023 May; 6(5):683-701. doi:
10.1021/acsptsci.2c00194. [PMID: 37200814] - Ritu Rani, Havagiray R Chitme, Neha Kukreti, Pankaj Pant, Basel A Abdel-Wahab, Masood Medleri Khateeb, Mohammed Shafiuddin Habeeb, Marwa B Bakir. Regulation of Insulin Resistance, Lipid Profile and Glucose Metabolism Associated with Polycystic Ovary Syndrome by Tinospora cordifolia.
Nutrients.
2023 May; 15(10):. doi:
10.3390/nu15102238. [PMID: 37242122] - Samuel D Offei, Hadi D Arman, Francis K Yoshimoto. Synthesis of menarandroside A from dehydroepiandrosterone.
Organic & biomolecular chemistry.
2023 Mar; ?(?):. doi:
10.1039/d3ob00054k. [PMID: 36950968] - Yijie Jiang, Jianshu Yang, Ke Du, Kaiming Luo, Xin Yuan, Fei Hua. 1,25-Dihydroxyvitamin D3 alleviates hyperandrogen-induced ferroptosis in KGN cells.
Hormones (Athens, Greece).
2023 Mar; ?(?):. doi:
10.1007/s42000-023-00439-5. [PMID: 36884209] - Fei Yu, Yanfeng Xue, Yunyan Zhao, Long Zhang, Xiao He, Zheng Liu. Isorhamnetin inhibits inflammatory response to alleviate DHEA-induced polycystic ovary syndrome in rats.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2023 Feb; ?(?):2183045. doi:
10.1080/09513590.2023.2183045. [PMID: 36842967] - Neşe Başak Türkmen, Hande Yüce, Muhterem Aydın, Aslı Taşlıdere, Ayşegül Doğan, Dilan Aşkın Özek, Taha Bartu Hayal, Şeyma Yaşar, Osman Çiftçi, Songül Ünüvar. Nerolidol attenuates dehydroepiandrosterone-induced polycystic ovary syndrome in rats by regulating oxidative stress and decreasing apoptosis.
Life sciences.
2023 Feb; 315(?):121380. doi:
10.1016/j.lfs.2023.121380. [PMID: 36640898] - Yao Yao, Ying Yang, Huihui Wang, Zhihao Jiang, Haitian Ma. Dehydroepiandrosterone alleviates oleic acid-induced lipid metabolism disorders through activation of AMPK-mTOR signal pathway in primary chicken hepatocytes.
Poultry science.
2023 Feb; 102(2):102385. doi:
10.1016/j.psj.2022.102385. [PMID: 36565630] - Xiaowei Ji, Yao Ye, Lin Wang, Suying Liu, Xi Dong. PDE4 inhibitor Roflumilast modulates inflammation and lipid accumulation in PCOS mice to improve ovarian function and reduce DHEA-induced granulosa cell apoptosis in vitro.
Drug development research.
2023 Jan; ?(?):. doi:
10.1002/ddr.22027. [PMID: 36621953] - Elliot D Mock, Berend Gagestein, Mario van der Stelt. Anandamide and other N-acylethanolamines: A class of signaling lipids with therapeutic opportunities.
Progress in lipid research.
2023 01; 89(?):101194. doi:
10.1016/j.plipres.2022.101194. [PMID: 36150527] - Shanshan Chen, Shuo Li, Xinxin Zhang, Yuxin Fan, Ming Liu. Low serum dehydroepiandrosterone is associated with diabetic dyslipidemia risk in males with type 2 diabetes.
Frontiers in endocrinology.
2023; 14(?):1272797. doi:
10.3389/fendo.2023.1272797. [PMID: 38075062] - S N Sankhwar, Pawan Kumar, Manashi Bagchi, Mehul Rungta, Debasis Bagchi. Safety and Efficacy of Furosap®, a Patented Trigonella foenum-graecum Seed Extract, in Boosting Testosterone Level, Reproductive Health and Mood Alleviation in Male Volunteers.
Journal of the American Nutrition Association.
2023 Jan; 42(1):27-35. doi:
10.1080/07315724.2021.1978348. [PMID: 34694954] - Jing Cong, Yuehui Zhang, Xinming Yang, Yu Wang, Hui He, Mengying Wang. Anti-polycystic ovary syndrome effect of electroacupuncture: IMD inhibits ER stress-mediated apoptosis and autophagy in granulosa cells.
Biochemical and biophysical research communications.
2022 12; 634(?):159-167. doi:
10.1016/j.bbrc.2022.10.030. [PMID: 36244114] - Fangxin Peng, Yichuan Hu, Shu Peng, Ni Zeng, Lei Shi. Apigenin exerts protective effect and restores ovarian function in dehydroepiandrosterone induced polycystic ovary syndrome rats: a biochemical and histological analysis.
Annals of medicine.
2022 Dec; 54(1):578-587. doi:
10.1080/07853890.2022.2034933. [PMID: 35152800] - He Ding, Youyuan Wang, Zhiqiang Li, Qianqing Li, Hongyu Liu, Jing Zhao, Wenfa Lu, Jun Wang. Baogong decoction treats endometritis in mice by regulating uterine microbiota structure and metabolites.
Microbial biotechnology.
2022 11; 15(11):2786-2799. doi:
10.1111/1751-7915.14127. [PMID: 35932174] - Ying-Li Cai, Feng Zhang, Xiu-Xiu Dou, Hua-Wu Zeng, Gao-Song Wu, Yan-Lin Liang, Xi-Ke Xu, Jing Zhao, Ji Ye, Wei-Dong Zhang. Integrated metabolomics and network pharmacology to reveal the therapeutic mechanism of Dingkun Pill on polycystic ovary syndrome.
Journal of ethnopharmacology.
2022 Sep; 295(?):115442. doi:
10.1016/j.jep.2022.115442. [PMID: 35688255] - Ying Li, Yanqiu Zhou, Zongwei Cai, Ruizhen Li, Pei Leng, Hongxiu Liu, Juan Liu, Gaga Mahai, Yuanyuan Li, Shunqing Xu, Wei Xia. Associations of benzotriazoles and benzothiazoles with estrogens and androgens among pregnant women: A cohort study with repeated measurements.
The Science of the total environment.
2022 Sep; 838(Pt 2):155998. doi:
10.1016/j.scitotenv.2022.155998. [PMID: 35588816] - Nazek Noureddine, Ivan Hartling, Paulina Wawrzyniak, Pakeerathan Srikanthan, Phing-How Lou, Eliana Lucchinetti, Stefanie D Krämer, Gerhard Rogler, Michael Zaugg, Martin Hersberger. Lipid emulsion rich in n-3 polyunsaturated fatty acids elicits a pro-resolution lipid mediator profile in mouse tissues and in human immune cells.
The American journal of clinical nutrition.
2022 09; 116(3):786-797. doi:
10.1093/ajcn/nqac131. [PMID: 35849016] - Yanli Hong, Jiayun Wu, Simin Yu, Miao Hui, Sipei Lin. Serum-Derived Exosomal microRNAs in Lipid Metabolism in Polycystic Ovary Syndrome.
Reproductive sciences (Thousand Oaks, Calif.).
2022 09; 29(9):2625-2635. doi:
10.1007/s43032-022-00930-1. [PMID: 35922742] - Ian-Arris de Bus, Antoine H P America, Norbert C A de Ruijter, Milena Lam, Jasper W van de Sande, Mieke Poland, Renger F Witkamp, Han Zuilhof, Michiel G J Balvers, Bauke Albada. PUFA-Derived N-Acylethanolamide Probes Identify Peroxiredoxins and Small GTPases as Molecular Targets in LPS-Stimulated RAW264.7 Macrophages.
ACS chemical biology.
2022 08; 17(8):2054-2064. doi:
10.1021/acschembio.1c00355. [PMID: 35867905] - Georgina Gallucci, Ariana Díaz, Rocío Del Valle Fernandez, Bettina Bongiovanni, Matilde Imhoff, Estefanía Massa, Natalia Santucci, Diego Bértola, Susana Lioi, María Luisa Bay, Oscar Bottasso, Luciano D'Attilio. Differential expression of genes regulated by the glucocorticoid receptor pathway in patients with pulmonary tuberculosis.
Life sciences.
2022 Jul; 301(?):120614. doi:
10.1016/j.lfs.2022.120614. [PMID: 35526591] - Soumita Mandal, Pradip Mukhopadhyay, Sujoy Ghosh. DHEA on Sexual Function in Sheehan Syndrome: A Randomized Double-Blind Placebo-Controlled Crossover Trial.
The Journal of clinical endocrinology and metabolism.
2022 07; 107(8):e3395-e3402. doi:
10.1210/clinem/dgac260. [PMID: 35481572] - Neeharika Sriram, Priyanka Madaan, Prahbhjot Malhi, Naresh Sachdeva, Sandeep Negi, Jhumki Das, Rakesh Kumar, Jitendra Kumar Sahu, Pratibha Singhi. Evaluation of Hyperandrogenism in Children with Autism Spectrum Disorder.
Indian journal of pediatrics.
2022 07; 89(7):717-719. doi:
10.1007/s12098-022-04080-9. [PMID: 35089488] - Kirsten S Wilson, Desheng Li, Iain Valentine, Alan McNeilly, Simon Girling, Rengui Li, Yingmin Zhou, Lynn Vanhaecke, W Colin Duncan, Jella Wauters. The novel use of urinary androgens to optimise detection of the fertile window in giant pandas.
Reproduction & fertility.
2022 07; 3(3):122-132. doi:
10.1530/raf-22-0031. [PMID: 35949393] - Wei-Wei Yin, Chang-Chang Huang, Yi-Ru Chen, Dan-Qing Yu, Min Jin, Chun Feng. The effect of medication on serum anti-müllerian hormone (AMH) levels in women of reproductive age: a meta-analysis.
BMC endocrine disorders.
2022 Jun; 22(1):158. doi:
10.1186/s12902-022-01065-9. [PMID: 35698127] - Zheng Wang, Ying Sun, Jing Jian Dong, Li Li Shi, Shoji F Nakayama, Teruhiko Kido, Chau-Ren Jung, Chaochen Ma, Hao Feng, Jin Guo Hang, Xian Liang Sun. Relationship between dioxins and steroid hormone in 6-year-olds: A follow-up study in an e-waste region of China.
Chemosphere.
2022 Jun; 296(?):134018. doi:
10.1016/j.chemosphere.2022.134018. [PMID: 35181420] - Jiana Huang, Peigen Chen, Yuting Xiang, Qiqi Liang, Taibao Wu, Jiawen Liu, Yanyan Zeng, Haitao Zeng, Xiaoyan Liang, Chuanchuan Zhou. Gut microbiota dysbiosis-derived macrophage pyroptosis causes polycystic ovary syndrome via steroidogenesis disturbance and apoptosis of granulosa cells.
International immunopharmacology.
2022 Jun; 107(?):108717. doi:
10.1016/j.intimp.2022.108717. [PMID: 35334358] - Liuxi Chu, Xin Shu, Yao Huang, Tong Chu, Meina Ge, Qin Lu. Sex steroid hormones in urinary exosomes as biomarkers for the prediction of prostate cancer.
Clinica chimica acta; international journal of clinical chemistry.
2022 Jun; 531(?):389-398. doi:
10.1016/j.cca.2022.04.995. [PMID: 35487250] - Shaoyan Zheng, Yanxia Chen, Mingying Ma, Miaoxia Li. Mechanism of quercetin on the improvement of ovulation disorder and regulation of ovarian CNP/NPR2 in PCOS model rats.
Journal of the Formosan Medical Association = Taiwan yi zhi.
2022 Jun; 121(6):1081-1092. doi:
10.1016/j.jfma.2021.08.015. [PMID: 34538551] - Brittany K Wise-Oringer, Anne Claire Burghard, Heekuk Park, Richard J Auchus, Sharon E Oberfield, Anne-Catrin Uhlemann. Salivary microbiome differences in prepubertal children with and without adrenal androgen excess.
Pediatric research.
2022 06; 91(7):1797-1803. doi:
10.1038/s41390-021-01661-w. [PMID: 34341500] - Rita Santos-Silva, Manuel Fontoura, João T Guimarães, Henrique Barros, Ana Cristina Santos. Association of dehydroepiandrosterone sulfate, birth size, adiposity and cardiometabolic risk factors in 7-year-old children.
Pediatric research.
2022 06; 91(7):1897-1905. doi:
10.1038/s41390-021-01706-0. [PMID: 34417562] - James Lin, Ting-Wan Kao, Ying-Chih Cheng, Kang-Chih Fan, Yu-Chen Huang, Che-Wei Liu. Dehydroepiandrosterone status and efficacy of dehydroepiandrosterone supplementation for bone health in anorexia nervosa: A systematic review and meta-analysis.
The International journal of eating disorders.
2022 06; 55(6):733-746. doi:
10.1002/eat.23714. [PMID: 35460091] - Yuxuan Zhang, Lingling Xu. Comparative study of DHEA and letrozole induced polycystic ovary syndrome in post-pubertal rats.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2022 May; 38(5):425-431. doi:
10.1080/09513590.2022.2052843. [PMID: 35311605] - Konstantinos I Papadopoulos, Alexandra Papadopoulou, Warachaya Sutheesophon, Tar-Choon Aw. Anti-SARS-CoV-2 Action of 5α-Reductase Inhibitors May Be Mediated by Dehydroepiandrosterone. Letter.
The Journal of urology.
2022 05; 207(5):1163-1164. doi:
10.1097/ju.0000000000002469. [PMID: 35119308] - Wenqi Jin, Chaonan Wang, Minghua Cui, Manying Wang, Baoyu Fu, Liwei Sun, Xin Chen. Inhibitory effect of bushen huoxue formula against dehydroepiandrosterone-induced inflammation in granulosa cells through TLR4/NF-κB signaling pathway.
Pakistan journal of pharmaceutical sciences.
2022 May; 35(3):701-710. doi:
. [PMID: 35791467] - Karina Gasbarrino, Edward Daly, Stella S Daskalopoulou. An LC-MS/MS Methodological Framework for Steroid Hormone Measurement from Human Serum.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2022 May; 54(5):300-307. doi:
10.1055/a-1768-0709. [PMID: 35352333] - Amin Ullah, Mei-Jiao Wang, Jun-Pu Yang, Enoch Appiah Adu-Gyamfi, Armin Czika, Sanjay Kumar Sah, Qian Feng, Ying-Xiong Wang. Ovarian inflammatory mRNA profiles of a dehydroepiandrosterone plus high-fat diet-induced polycystic ovary syndrome mouse model.
Reproductive biomedicine online.
2022 05; 44(5):791-802. doi:
10.1016/j.rbmo.2021.10.024. [PMID: 35370096] - Claes Ohlsson, Marcus Langenskiöld, Kristian Smidfelt, Matti Poutanen, Henrik Ryberg, Anna-Karin Norlén, Joakim Nordanstig, Göran Bergström, Åsa Tivesten. Low Progesterone and Low Estradiol Levels Associate With Abdominal Aortic Aneurysms in Men.
The Journal of clinical endocrinology and metabolism.
2022 03; 107(4):e1413-e1425. doi:
10.1210/clinem/dgab867. [PMID: 34865072] - Christian Weinland, Christiane Mühle, Claudia von Zimmermann, Johannes Kornhuber, Bernd Lenz. Sulphated dehydroepiandrosterone serum levels are reduced in women with alcohol use disorder and correlate negatively with craving: A sex-separated cross-sectional and longitudinal study.
Addiction biology.
2022 03; 27(2):e13135. doi:
10.1111/adb.13135. [PMID: 35229954] - Robert T Chatterton. Functions of dehydroepiandrosterone in relation to breast cancer.
Steroids.
2022 03; 179(?):108970. doi:
10.1016/j.steroids.2022.108970. [PMID: 35122788] - Hanaa Tarek El-Zawawy, Aliaa Aly El-Aghoury, Khaled Mohamed Katri, Eman Mohamed El-Sharkawy, Samar Mohamed Samy Gad. Cortisol/DHEA ratio in morbidly obese patients before and after bariatric surgery: Relation to metabolic parameters and cardiovascular performance.
International journal of obesity (2005).
2022 02; 46(2):381-392. doi:
10.1038/s41366-021-00997-x. [PMID: 34725442] - Muhammad Imran, Luping Zhang, Bohan Zheng, Zikai Zhao, Dengyuan Zhou, Shengfeng Wan, Zheng Chen, Hongyu Duan, Qiuyan Li, Xueqin Liu, Shengbo Cao, Shaoyong Ke, Jing Ye. Screening of novel synthetic derivatives of dehydroepiandrosterone for antivirals against flaviviruses infections.
Virologica Sinica.
2022 Feb; 37(1):94-106. doi:
10.1016/j.virs.2022.01.007. [PMID: 35234626] - Siwei Zhang, Jing Zhou, Lijuan Li, Xinyao Pan, Jing Lin, Chuyu Li, Wing Ting Leung, Ling Wang. Effect of dehydroepiandrosterone on atherosclerosis in postmenopausal women.
Bioscience trends.
2022 Jan; 15(6):353-364. doi:
10.5582/bst.2021.01320. [PMID: 34759119] - Tiange Li, Yue Zhang, Jiajia Song, Lijun Chen, Min Du, Xueying Mao. Yogurt Enriched with Inulin Ameliorated Reproductive Functions and Regulated Gut Microbiota in Dehydroepiandrosterone-Induced Polycystic Ovary Syndrome Mice.
Nutrients.
2022 Jan; 14(2):. doi:
10.3390/nu14020279. [PMID: 35057459] - Youran Li, Yanhong Zhai, Lin Li, Yifan Lu, Shaofei Su, Ying Liu, Zhengwen Xu, Mingwei Xin, Qiaoli Zhang, Zheng Cao. Divergent Associations Between Serum Androgens and Ovarian Reserve Markers Revealed in Patients With Polycystic Ovary Syndrome.
Frontiers in endocrinology.
2022; 13(?):881740. doi:
10.3389/fendo.2022.881740. [PMID: 35757414] - Yosef Tsegaye, Wasihun Admassu, Abebe Edao, Samuel Kinde, Meaza Gentu, Markos Negash, Tadelo Wondmagegn, Addisu Gize, Martha Zewdie, Kidist Bobosha, Liya Wassie. Alteration of Endocrine Hormones and Antibody Responses in Different Spectrum of Tuberculosis Disease.
Frontiers in immunology.
2022; 13(?):849321. doi:
10.3389/fimmu.2022.849321. [PMID: 35281036] - Xuejiao Wang, Liping Gu, Yahui Zhang, Chuanhao Xiong, Yongde Peng, Xiaoying Ding. Effects of dehydroepiandrosterone alone or in combination with a high-fat diet and antibiotic cocktail on the heterogeneous phenotypes of PCOS mouse models by regulating gut microbiota.
Frontiers in endocrinology.
2022; 13(?):1030151. doi:
10.3389/fendo.2022.1030151. [PMID: 36619569] - Xinxin Zhang, Jinfeng Xiao, Tong Liu, Qing He, Jingqiu Cui, Shaofang Tang, Xin Li, Ming Liu. Low Serum Dehydroepiandrosterone and Dehydroepiandrosterone Sulfate Are Associated With Coronary Heart Disease in Men With Type 2 Diabetes Mellitus.
Frontiers in endocrinology.
2022; 13(?):890029. doi:
10.3389/fendo.2022.890029. [PMID: 35832423] - Baoying Liao, Xinyu Qi, Chuyu Yun, Jie Qiao, Yanli Pang. Effects of Androgen Excess-Related Metabolic Disturbances on Granulosa Cell Function and Follicular Development.
Frontiers in endocrinology.
2022; 13(?):815968. doi:
10.3389/fendo.2022.815968. [PMID: 35237237] - Xinxin Zhang, Jinfeng Xiao, Xin Li, Jingqiu Cui, Kunling Wang, Qing He, Ming Liu. Low Serum Dehydroepiandrosterone Is Associated With Diabetic Kidney Disease in Men With Type 2 Diabetes Mellitus.
Frontiers in endocrinology.
2022; 13(?):915494. doi:
10.3389/fendo.2022.915494. [PMID: 35784547] - Aarthi Sundararajan, Kranti Vora, Shahin Saiyed, Senthilkumar Natesan. Comparative profiling of prenatal cortisol and DHEA-S among pregnant women with poor birth outcome and pregnant women with normal birth outcome.
Clinical endocrinology.
2021 12; 95(6):863-872. doi:
10.1111/cen.14569. [PMID: 34370329] - Dongke Liu, Rusong Zhao, Shigang Zhao, Zhaobao Wang, Ruichen Liu, Fengshan Wang, Yanhui Gao. A developed HPLC-MS/MS method to quantitate 5 steriod hormones in clinical human serum by using PBS as the surrogate matrix.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
2021 Dec; 1186(?):123002. doi:
10.1016/j.jchromb.2021.123002. [PMID: 34749247] - Benedikt A Gasser, Samuel F Buerki, Johann Kurz, Markus G Mohaupt. Hyperandrogenism? Increased 17, 20-Lyase Activity? A Metanalysis and Systematic Review of Altered Androgens in Boys and Girls with Autism.
International journal of molecular sciences.
2021 Nov; 22(22):. doi:
10.3390/ijms222212324. [PMID: 34830216] - Maja Arena Jørgensen, Karen Johanne Pallesen, Lone Overby Fjorback, Lise Juul. Effect of Mindfulness-Based Stress Reduction on dehydroepiandrosterone-sulfate in adults with self-reported stress. A randomized trial.
Clinical and translational science.
2021 11; 14(6):2360-2369. doi:
10.1111/cts.13100. [PMID: 34121351] - Lu-Ming Wu, Yin-Xue Wang, Yue Zhan, A-Hui Liu, Yi-Xiang Wang, Hao-Fei Shen, Yi-Fan Wang, Li-Yan Wang, Zhong-Bin Tao, Yi-Qing Wang. Dulaglutide, a long-acting GLP-1 receptor agonist, can improve hyperandrogenemia and ovarian function in DHEA-induced PCOS rats.
Peptides.
2021 11; 145(?):170624. doi:
10.1016/j.peptides.2021.170624. [PMID: 34375684] - M Probo, T Peric, J Fusi, A Prandi, M Faustini, M C Veronesi. Hair cortisol and dehydroepiandrosterone sulfate concentrations in healthy beef calves from birth to 6 months of age.
Theriogenology.
2021 Nov; 175(?):89-94. doi:
10.1016/j.theriogenology.2021.08.037. [PMID: 34517287] - Majiyd Abdul Noushin, Apeksha Sahu, Swati Singh, Sankalp Singh, Kannamannadiar Jayaprakasan, Reema Basheer, Aravind Ramachandran, Mohamed Ashraf. Dehydroepiandrosterone (DHEA) role in enhancement and maintenance of implantation (DREAM): randomised double-blind placebo-controlled trial-study protocol.
BMJ open.
2021 10; 11(10):e054251. doi:
10.1136/bmjopen-2021-054251. [PMID: 34706964] - Arianna Ventura-Bahena, Jesús Gibran Hernández-Pérez, Luisa Torres-Sánchez, Adolfo Sierra-Santoyo, Derly Constanza Escobar-Wilches, Consuelo Escamilla-Núñez, Rocio Gómez, Francisco Rodríguez-Covarrubias, Ma de Lourdes López-González, Mario Figueroa. Urinary androgens excretion patterns and prostate cancer in Mexican men.
Endocrine-related cancer.
2021 10; 28(12):745-756. doi:
10.1530/erc-21-0160. [PMID: 34520388] - Ai Lin Daphne Teh, Jaime Jacqueline Jayapalan, Mun Fai Loke, Azida Juana Wan Abdul Kadir, Visvaraja Subrayan. Identification of potential serum metabolic biomarkers for patient with keratoconus using untargeted metabolomics approach.
Experimental eye research.
2021 10; 211(?):108734. doi:
10.1016/j.exer.2021.108734. [PMID: 34428458] - K M Bermingham, L Brennan, R Segurado, I J Gray, R E Barron, E R Gibney, M F Ryan, M J Gibney, J W Newman, Dr A M O'Sullivan. Genetic and environmental influences on serum oxylipins, endocannabinoids, bile acids and steroids.
Prostaglandins, leukotrienes, and essential fatty acids.
2021 10; 173(?):102338. doi:
10.1016/j.plefa.2021.102338. [PMID: 34500309] - Pardes Habib, Joseph Neulen, Shahin Habib, Benjamin Rösing. Dehydroepiandrosterone (DHEA) Serum Levels Indicate Cerebrospinal Fluid Levels of DHEA and Estradiol (E2) in Women at Term Pregnancy.
Reproductive sciences (Thousand Oaks, Calif.).
2021 10; 28(10):2823-2829. doi:
10.1007/s43032-021-00541-2. [PMID: 33772479] - Guglielmina Chimienti, Antonella Orlando, Francesco Russo, Benedetta D'Attoma, Manuela Aragno, Eleonora Aimaretti, Angela Maria Serena Lezza, Vito Pesce. The Mitochondrial Trigger in an Animal Model of Nonalcoholic Fatty Liver Disease.
Genes.
2021 09; 12(9):. doi:
10.3390/genes12091439. [PMID: 34573421] - Sojit Tomo, Mithu Banerjee, Praveen Sharma, Mahendra Garg. Does dehydroepiandrosterone sulfate have a role in COVID-19 prognosis and treatment?.
Endocrine regulations.
2021 Sep; 55(3):174-181. doi:
10.2478/enr-2021-0019. [PMID: 34523302] - Yan Zhu, Lei Qiu, Fangfang Jiang, Mihnea-Alexandru Găman, Ohoud Saleh Abudoraehem, Kehinde S Okunade, Ming Zhang. The effect of dehydroepiandrosterone (DHEA) supplementation on estradiol levels in women: A dose-response and meta-analysis of randomized clinical trials.
Steroids.
2021 09; 173(?):108889. doi:
10.1016/j.steroids.2021.108889. [PMID: 34246664] - Robert Krysiak, Witold Szkróbka, Bogusław Okopień. Impact of dehydroepiandrosterone on thyroid autoimmunity and function in men with autoimmune hypothyroidism.
International journal of clinical pharmacy.
2021 Aug; 43(4):998-1005. doi:
10.1007/s11096-020-01207-w. [PMID: 33245519] - Manuel Dote-Montero, Alejandro De-la-O, Lucas Jurado-Fasoli, Jonatan R Ruiz, Manuel J Castillo, Francisco J Amaro-Gahete. The effects of three types of exercise training on steroid hormones in physically inactive middle-aged adults: a randomized controlled trial.
European journal of applied physiology.
2021 Aug; 121(8):2193-2206. doi:
10.1007/s00421-021-04692-7. [PMID: 33890158] - Wang Chen, Daihua Hu, Zili Feng, Zhaopeng Liu. An effective synthesis of ursodeoxycholic acid from dehydroepiandrosterone.
Steroids.
2021 08; 172(?):108870. doi:
10.1016/j.steroids.2021.108870. [PMID: 34038744] - Maria Grazia Matarazzo, Giuseppe Sarpietro, Debora Fiorito, Salvatore Di Pasqua, Simona Ingrassano, Marco Marzio Panella, Antonio Cianci, Salvatore Caruso. Intravaginal 6.5 mg prasterone administration in postmenopausal women with overactive bladder syndrome: A pilot study.
European journal of obstetrics, gynecology, and reproductive biology.
2021 Aug; 263(?):67-71. doi:
10.1016/j.ejogrb.2021.06.009. [PMID: 34167036] - Conor Bentley, Claire Potter, Kamal Makram Yakoub, Kristian Brock, Victoria Homer, Emma Toman, Angela E Taylor, Fozia Shaheen, Lorna C Gilligan, Amrita Athwal, Darren Barton, Ronald Carrera, Katie Young, Amisha Desai, Kirsty McGee, Christos Ermogenous, Gurneet Sur, Carolyn A Greig, Jon Hazeldine, Wiebke Arlt, Janet M Lord, Mark A Foster. A prospective, phase II, single-centre, cross-sectional, randomised study investigating Dehydroepiandrosterone supplementation and its Profile in Trauma: ADaPT.
BMJ open.
2021 07; 11(7):e040823. doi:
10.1136/bmjopen-2020-040823. [PMID: 34312190] - Dayamín Martínez Brito, Patrizia Leogrande, Cristiana Colamonici, Davide Curcio, Francesco Botre, Xavier de la Torre. Arimistane: Degradation product or metabolite of 7-oxo-DHEA?.
Drug testing and analysis.
2021 Jul; 13(7):1430-1439. doi:
10.1002/dta.3036. [PMID: 33783974] - Yogamaya D Prabhu, Monica Bhati, Balachandar Vellingiri, Abilash Valsala Gopalakrishnan. The effect of γ-linolenic acid on Polycystic Ovary Syndrome associated Focal Segmental Glomerulosclerosis via TGF-β pathway.
Life sciences.
2021 Jul; 276(?):119456. doi:
10.1016/j.lfs.2021.119456. [PMID: 33811895] - Christopher J Papayannakos, James A DeVoti, Mohd Israr, Habeeb Alsudani, Vincent Bonagura, Bettie M Steinberg. Extracellular vesicles produced by primary human keratinocytes in response to TLR agonists induce stimulus-specific responses in antigen-presenting cells.
Cellular signalling.
2021 07; 83(?):109994. doi:
10.1016/j.cellsig.2021.109994. [PMID: 33781846] - Huiyi Yang, Qiyi He, Sergei A Eremin, Junkang Pan, Yikui Zou, Xiping Cui, Suqing Zhao. Fluorescence polarization immunoassay for rapid determination of dehydroepiandrosterone in human urine.
Analytical and bioanalytical chemistry.
2021 Jul; 413(17):4459-4469. doi:
10.1007/s00216-021-03403-7. [PMID: 34137913] - Donna Elizabeth Sunny, Elke Hammer, Till Ittermann, Elisabeth Luise Krüger, Stephanie Hübner, Michaela Friederike Hartmann, Stefan Alexander Wudy, Uwe Völker, Matthias Heckmann. Fetal Zone Steroids and Estrogen Show Sex Specific Effects on Oligodendrocyte Precursor Cells in Response to Oxidative Damage.
International journal of molecular sciences.
2021 Jun; 22(12):. doi:
10.3390/ijms22126586. [PMID: 34205405] - Anna Kiersztan, Kongorzul Gaanga, Apolonia Witecka, Adam K Jagielski. DHEA-pretreatment attenuates oxidative stress in kidney-cortex and liver of diabetic rabbits and delays development of the disease.
Biochimie.
2021 Jun; 185(?):135-145. doi:
10.1016/j.biochi.2021.03.010. [PMID: 33771656] - Paulina Lipinska, Ewa Sell-Kubiak, Piotr Pawlak, Zofia Eliza Madeja, Ewelina Warzych. Response of Bovine Cumulus-Oocytes Complexes to Energy Pathway Inhibition during In Vitro Maturation.
Genes.
2021 05; 12(6):. doi:
10.3390/genes12060838. [PMID: 34072406] - Shibani S Mukerji, Vikas Misra, David R Lorenz, Sukrutha Chettimada, Kiana Keller, Scott Letendre, Ronald J Ellis, Susan Morgello, Robert A Parker, Dana Gabuzda. Low Neuroactive Steroids Identifies a Biological Subtype of Depression in Adults with Human Immunodeficiency Virus on Suppressive Antiretroviral Therapy.
The Journal of infectious diseases.
2021 05; 223(9):1601-1611. doi:
10.1093/infdis/jiaa104. [PMID: 32157292] - Zaixin Guo, Xiaohan Chen, Penghui Feng, Qi Yu. Short-term rapamycin administration elevated testosterone levels and exacerbated reproductive disorder in dehydroepiandrosterone-induced polycystic ovary syndrome mice.
Journal of ovarian research.
2021 May; 14(1):64. doi:
10.1186/s13048-021-00813-0. [PMID: 33947426] - Sebastião Freitas de Medeiros, Bruna Barcelo Barbosa, Ana Karine Lin Winck Yamamoto de Medeiros, Matheus Antônio Souto de Medeiros, Márcia Marly Winck Yamamoto. Differential Effects of Various Androgens on Polycystic Ovary Syndrome.
Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme.
2021 May; 53(5):341-349. doi:
10.1055/a-1422-3243. [PMID: 33878788] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Huiyi Yang, Qiyi He, Junkang Pan, Ding Shen, Huanxin Xiao, Xiping Cui, Suqing Zhao. A Pt-Ir nanocube amplified lateral flow immunoassay for dehydroepiandrosterone.
The Analyst.
2021 Apr; 146(8):2726-2733. doi:
10.1039/d0an02293d. [PMID: 33709090] - J Ghassemi Nejad, B-H Lee, J-Y Kim, B Chemere, K-I Sung, H-G Lee. Effect of alpine grazing on plasma and hair cortisol, serotonin, and DHEA in dairy cows and its welfare impact.
Domestic animal endocrinology.
2021 04; 75(?):106581. doi:
10.1016/j.domaniend.2020.106581. [PMID: 33189967] - Chrysanthi Tsika, Manolis N Tzatzarakis, Sophia G Antimisiaris, Pavlina Tsoka, Paschalis Efstathopoulos, Ioannis Charalampopoulos, Achille Gravanis, Miltiadis K Tsilimbaris. Quantification of BNN27, a novel neuroprotective 17-spiroepoxy dehydroepiandrosterone derivative in the blood and retina of rodents, after single intraperitoneal administration.
Pharmacology research & perspectives.
2021 04; 9(2):e00724. doi:
10.1002/prp2.724. [PMID: 33638308] - Violeta Lokaj-Berisha, Besa Gacaferri Lumezi, Naser Berisha. Low serum levels of dehydroepiandrosterone sulfate and testosterone in Albanian female patients with allergic disease.
Scientific reports.
2021 03; 11(1):5611. doi:
10.1038/s41598-021-85214-5. [PMID: 33692458] - María Belén Vecchione, Matías Tomás Angerami, Guadalupe Verónica Suarez, Gabriela Turk, Natalia Laufer, Graciela Ben, Diego Ameri, Diego Gonzalez, Laura M Parodi, Luis D Giavedoni, Patricia Maidana, Bibiana Fabre, Viviana Mesch, Omar Sued, Maria Florencia Quiroga. Immune variations throughout the course of tuberculosis treatment and its relationship with adrenal hormone changes in HIV-1 patients co-infected with Mycobacterium tuberculosis.
Tuberculosis (Edinburgh, Scotland).
2021 03; 127(?):102045. doi:
10.1016/j.tube.2020.102045. [PMID: 33434785] - Rosemary Basson. Sexual Dysfunctions in Women: Are Androgens at Fault?.
Endocrinology and metabolism clinics of North America.
2021 03; 50(1):125-138. doi:
10.1016/j.ecl.2020.12.001. [PMID: 33518181] - Karine Lalonde, Andrew Barber, Christiane Ayotte. Two-dimensional high performance liquid chromatography purification of underivatized urinary testosterone and metabolites for compound-specific stable carbon isotope analysis.
Drug testing and analysis.
2021 Mar; 13(3):558-570. doi:
10.1002/dta.2964. [PMID: 33151038]
