trifluoperazine (BioDeep_00000406050)
Main id: BioDeep_00000001953
natural product
代谢物信息卡片
Trifluoperazine aka 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine
化学式: C21H24F3N3S (407.1643)
中文名称: 三氟拉嗪
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F
InChI: InChI=1S/C21H24F3N3S/c1-25-11-13-26(14-12-25)9-4-10-27-17-5-2-3-6-19(17)28-20-8-7-16(15-18(20)27)21(22,23)24/h2-3,5-8,15H,4,9-14H2,1H3
描述信息
N - Nervous system > N05 - Psycholeptics > N05A - Antipsychotics > N05AB - Phenothiazines with piperazine structure
D002492 - Central Nervous System Depressants > D014149 - Tranquilizing Agents > D014150 - Antipsychotic Agents
D002491 - Central Nervous System Agents > D011619 - Psychotropic Drugs > D014149 - Tranquilizing Agents
D018377 - Neurotransmitter Agents > D015259 - Dopamine Agents > D018492 - Dopamine Antagonists
C78272 - Agent Affecting Nervous System > C267 - Antiemetic Agent > C740 - Phenothiazine
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents
C78272 - Agent Affecting Nervous System > C29710 - Antipsychotic Agent
D005765 - Gastrointestinal Agents > D000932 - Antiemetics
同义名列表
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:45951
- KEGG: C07168
- KEGGdrug: D08636
- PubChem: 5566
- DrugBank: DB00831
- ChEMBL: CHEMBL422
- MeSH: Trifluoperazine
- CAS: 1432064-02-2
- CAS: 81498-90-0
- CAS: 117-89-5
- MoNA: CCMSLIB00000079172
- MoNA: FiehnHILIC002383
- MoNA: FiehnHILIC000814
- PubChem: 9377
- PDB-CCD: TFP
- NIKKAJI: J5.293K
- KNApSAcK: 45951
- LOTUS: LTS0156745
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
11 个相关的物种来源信息
- 3828 - Crotalaria: LTS0156745
- 671522 - Crotalaria assamica: 10.1016/J.BMCL.2003.11.074
- 671522 - Crotalaria assamica: LTS0156745
- 3830 - Crotalaria pallida: 10.1016/J.BMCL.2003.11.074
- 3830 - Crotalaria pallida: LTS0156745
- 2759 - Eukaryota: LTS0156745
- 3803 - Fabaceae: LTS0156745
- 3398 - Magnoliopsida: LTS0156745
- 35493 - Streptophyta: LTS0156745
- 58023 - Tracheophyta: LTS0156745
- 33090 - Viridiplantae: LTS0156745
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Gautam Kumar, Shobhna Kapoor. Targeting mycobacterial membranes and membrane proteins: Progress and limitations.
Bioorganic & medicinal chemistry.
2023 03; 81(?):117212. doi:
10.1016/j.bmc.2023.117212. [PMID: 36804747] - Qianqian Jiang, Renyan Mao, Yongcai Li, Yang Bi, Yongxiang Liu, Miao Zhang, Rong Li, Yangyang Yang, Dov B Prusky. AaCaM is required for infection structure differentiation and secondary metabolites in pear fungal pathogen Alternaria alternata.
Journal of applied microbiology.
2022 Oct; 133(4):2631-2641. doi:
10.1111/jam.15732. [PMID: 35870147] - Ahmed E Goda, Amr M Elenany, Alaa E Elsisi. Novel in vivo potential of trifluoperazine to ameliorate doxorubicin-induced cardiotoxicity involves suppression of NF-κB and apoptosis.
Life sciences.
2021 Oct; 283(?):119849. doi:
10.1016/j.lfs.2021.119849. [PMID: 34343539] - Rodrigo R R Duarte, Dennis C Copertino, Luis P Iñiguez, Jez L Marston, Yaron Bram, Yuling Han, Robert E Schwartz, Shuibing Chen, Douglas F Nixon, Timothy R Powell. Identifying FDA-approved drugs with multimodal properties against COVID-19 using a data-driven approach and a lung organoid model of SARS-CoV-2 entry.
Molecular medicine (Cambridge, Mass.).
2021 09; 27(1):105. doi:
10.1186/s10020-021-00356-6. [PMID: 34503440] - Nicole J Sylvain, Mootaz M Salman, M Jake Pushie, Huishu Hou, Vedashree Meher, Rasmus Herlo, Lissa Peeling, Michael E Kelly. The effects of trifluoperazine on brain edema, aquaporin-4 expression and metabolic markers during the acute phase of stroke using photothrombotic mouse model.
Biochimica et biophysica acta. Biomembranes.
2021 05; 1863(5):183573. doi:
10.1016/j.bbamem.2021.183573. [PMID: 33561476] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Ruimei Zhou, Jiashun Liao, Dunpeng Cai, Qin Tian, Enping Huang, Tianming Lü, Shi-You Chen, Wei-Bing Xie. Nupr1 mediates renal fibrosis via activating fibroblast and promoting epithelial-mesenchymal transition.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
2021 03; 35(3):e21381. doi:
10.1096/fj.202000926rr. [PMID: 33617091] - Anmao Li, Xuanxin Chen, Zizi Jing, Jianbin Chen. Trifluoperazine induces cellular apoptosis by inhibiting autophagy and targeting NUPR1 in multiple myeloma.
FEBS open bio.
2020 10; 10(10):2097-2106. doi:
10.1002/2211-5463.12960. [PMID: 32810364] - Arumugam Sangili, Rajalakshmi Sakthivel, Shen Ming Chen. Cost-effective single-step synthesis of flower-like cerium-ruthenium-sulfide for the determination of antipsychotic drug trifluoperazine in human urine samples.
Analytica chimica acta.
2020 Sep; 1131(?):35-44. doi:
10.1016/j.aca.2020.07.032. [PMID: 32928478] - Amir Kiani, Shadi Heydari Nik, Adineh Khodadoost, Ahmad Salimi, Jalal Pourahmad. Trifluoperazine an Antipsychotic Drug and Inhibitor of Mitochondrial Permeability Transition Protects Cytarabine and Ifosfamide-Induced Neurotoxicity.
Drug research.
2020 Jun; 70(6):265-272. doi:
10.1055/a-1154-8672. [PMID: 32365382] - Qi Ding, Ferzin Sethna, Xue-Ting Wu, Zhuang Miao, Ping Chen, Yueqi Zhang, Hua Xiao, Wei Feng, Yue Feng, Xuan Li, Hongbing Wang. Transcriptome signature analysis repurposes trifluoperazine for the treatment of fragile X syndrome in mouse model.
Communications biology.
2020 03; 3(1):127. doi:
10.1038/s42003-020-0833-4. [PMID: 32179850] - Darpan Raghav, Susobhan Mahanty, Krishnan Rathinasamy. Characterizing the interactions of the antipsychotic drug trifluoperazine with bovine serum albumin: Probing the drug-protein and drug-drug interactions using multi-spectroscopic approaches.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.
2020 Feb; 226(?):117584. doi:
10.1016/j.saa.2019.117584. [PMID: 31698317] - Yanzhe Li, Yueyuan Yin, Jinyi Ma, Yanan Sun, Ruimin Zhou, Bo Cui, Yuxuan Zhang, Jie Yang, Xiaojie Yan, Zhe Liu, Zhenyi Ma. Combination of AAV‑mediated NUPR1 knockdown and trifluoperazine induces premature senescence in human lung adenocarcinoma A549 cells in nude mice.
Oncology reports.
2020 02; 43(2):681-688. doi:
10.3892/or.2020.7455. [PMID: 31922247] - Shuaishuai Ni, Xin Chen, Qing Yu, Yixiang Xu, Zhiguo Hu, Junqian Zhang, Wenjuan Zhang, Baoli Li, Xi Yang, Fei Mao, Jing Huang, Yi Sun, Jian Li, Lijun Jia. Discovery of candesartan cilexetic as a novel neddylation inhibitor for suppressing tumor growth.
European journal of medicinal chemistry.
2020 Jan; 185(?):111848. doi:
10.1016/j.ejmech.2019.111848. [PMID: 31732254] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Zhong-Guang Li, Xin-Yu Ye, Xue-Mei Qiu. Glutamate signaling enhances the heat tolerance of maize seedlings by plant glutamate receptor-like channels-mediated calcium signaling.
Protoplasma.
2019 Jul; 256(4):1165-1169. doi:
10.1007/s00709-019-01351-9. [PMID: 30675652] - Baodong Wang, Yankun Luo, Xiaoshuang Zhou, Rongshan Li. Trifluoperazine induces apoptosis through the upregulation of Bax/Bcl‑2 and downregulated phosphorylation of AKT in mesangial cells and improves renal function in lupus nephritis mice.
International journal of molecular medicine.
2018 Jun; 41(6):3278-3286. doi:
10.3892/ijmm.2018.3562. [PMID: 29568865] - Jingwen Jiang, Zhongxi Huang, Xuewu Chen, Rongcheng Luo, Hongbin Cai, Hairu Wang, Hui Zhang, Tao Sun, Yunfang Zhang. Trifluoperazine Activates FOXO1-Related Signals to Inhibit Tumor Growth in Hepatocellular Carcinoma.
DNA and cell biology.
2017 10; 36(10):813-821. doi:
10.1089/dna.2017.3790. [PMID: 28876084] - Baodong Wang, Xiaoshuang Zhou, Yanqin Wang, Rongshan Li. Trifluoperazine Inhibits Mesangial Cell Proliferation by Arresting Cell Cycle-Dependent Mechanisms.
Medical science monitor : international medical journal of experimental and clinical research.
2017 Jul; 23(?):3461-3469. doi:
10.12659/msm.902522. [PMID: 28713151] - Ching-Hua Lin, Fu-Chiang Wang, Shih-Chi Lin, Yu-Hui Huang, Cheng-Chung Chen. A randomized, double-blind, comparison of the efficacy and safety of low-dose olanzapine plus low-dose trifluoperazine versus full-dose olanzapine in the acute treatment of schizophrenia.
Schizophrenia research.
2017 07; 185(?):80-87. doi:
10.1016/j.schres.2017.01.004. [PMID: 28109665] - Swaminath Srinivas, John E Cronan. An Eight-Residue Deletion in Escherichia coli FabG Causes Temperature-Sensitive Growth and Lipid Synthesis Plus Resistance to the Calmodulin Inhibitor Trifluoperazine.
Journal of bacteriology.
2017 05; 199(10):. doi:
10.1128/jb.00074-17. [PMID: 28264990] - Min Xu, Peipei Dong, Xiangge Tian, Chao Wang, Xiaokui Huo, Baojing Zhang, Lijun Wu, Sa Deng, Xiaochi Ma. Drug interaction study of natural steroids from herbs specifically toward human UDP-glucuronosyltransferase (UGT) 1A4 and their quantitative structure activity relationship (QSAR) analysis for prediction.
Pharmacological research.
2016 08; 110(?):139-150. doi:
10.1016/j.phrs.2016.05.013. [PMID: 27208893] - Wei Chen, Hongming Su, Lina Feng, Xiaodong Zheng. Andrographolide suppresses preadipocytes proliferation through glutathione antioxidant systems abrogation.
Life sciences.
2016 Jul; 156(?):21-29. doi:
10.1016/j.lfs.2016.05.030. [PMID: 27221023] - Xia Lv, Xin-Xin Wang, Jie Hou, Zhong-Ze Fang, Jing-Jing Wu, Yun-Feng Cao, Shu-Wen Liu, Guang-Bo Ge, Ling Yang. Comparison of the inhibitory effects of tolcapone and entacapone against human UDP-glucuronosyltransferases.
Toxicology and applied pharmacology.
2016 06; 301(?):42-9. doi:
10.1016/j.taap.2016.04.009. [PMID: 27089846] - Tetsuya Nakamura, Jun Kamishikiryo, Tetsuo Morita. Prazosin-stimulated release of hepatic triacylglyceride lipase from primary cultured rat hepatocytes is involved in the regulation of cAMP-dependent protein kinase through activation of the Ca(2+)/calmodulin-dependent protein kinase-II.
Pharmacological reports : PR.
2016 Jun; 68(3):649-53. doi:
10.1016/j.pharep.2016.02.001. [PMID: 27031052] - Dan Liu, Jie Wu, Hongbo Xie, Mingyi Liu, Isaiah Takau, Hong Zhang, Yuqing Xiong, Chunhua Xia. Inhibitory Effect of Hesperetin and Naringenin on Human UDP-Glucuronosyltransferase Enzymes: Implications for Herb-Drug Interactions.
Biological & pharmaceutical bulletin.
2016; 39(12):2052-2059. doi:
10.1248/bpb.b16-00581. [PMID: 27904048] - A I Yemets, V V Fedorchuk, Ya B Blume. [ENHANCEMENT OF AGROBACTERIAL TRANSFORMATION OF PLANTS USING PROTEIN KINASE INHIBITORS TRIFLUOPERAZINE AND GENISTEIN].
TSitologiia i genetika.
2016 Jan; 50(1):3-11. doi:
. [PMID: 27266180] - Stephanie N Brosius, Amy N Turk, Stephanie J Byer, Jody Fromm Longo, John C Kappes, Kevin A Roth, Steven L Carroll. Combinatorial therapy with tamoxifen and trifluoperazine effectively inhibits malignant peripheral nerve sheath tumor growth by targeting complementary signaling cascades.
Journal of neuropathology and experimental neurology.
2014 Nov; 73(11):1078-90. doi:
10.1097/nen.0000000000000126. [PMID: 25289889] - Bang An, Yong Chen, Boqiang Li, Guozheng Qin, Shiping Tian. Ca(2+)-CaM regulating viability of Candida guilliermondii under oxidative stress by acting on detergent resistant membrane proteins.
Journal of proteomics.
2014 Sep; 109(?):38-49. doi:
10.1016/j.jprot.2014.06.022. [PMID: 24998432] - Abdol Mohammad Attaran, Narges Mohammadi, Mehran Javanbakht, Behrouz Akbari-Adergani. Molecularly imprinted solid-phase extraction for selective trace analysis of trifluoperazine.
Journal of chromatographic science.
2014 Aug; 52(7):730-8. doi:
10.1093/chromsci/bmt074. [PMID: 23788020] - Zhong-Ze Fang, Rong-Rong He, Yun-Feng Cao, Naoki Tanaka, Changtao Jiang, Kristopher W Krausz, Yunpeng Qi, Pei-Pei Dong, Chun-Zhi Ai, Xiao-Yu Sun, Mo Hong, Guang-Bo Ge, Frank J Gonzalez, Xiao-Chi Ma, Hong-Zhi Sun. A model of in vitro UDP-glucuronosyltransferase inhibition by bile acids predicts possible metabolic disorders.
Journal of lipid research.
2013 Dec; 54(12):3334-44. doi:
10.1194/jlr.m040519. [PMID: 24115227] - Janet Genz, Benjamin Carriere, W Gary Anderson. Mechanisms of calcium absorption by anterior and posterior segments of the intestinal tract of juvenile lake sturgeon.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.
2013 Oct; 166(2):293-301. doi:
10.1016/j.cbpa.2013.06.033. [PMID: 23831300] - Ana M Chamoun-Emanuelli, Eve-Isabelle Pecheur, Rudo L Simeon, Da Huang, Paul S Cremer, Zhilei Chen. Phenothiazines inhibit hepatitis C virus entry, likely by increasing the fluidity of cholesterol-rich membranes.
Antimicrobial agents and chemotherapy.
2013 Jun; 57(6):2571-81. doi:
10.1128/aac.02593-12. [PMID: 23529728] - Liang Luo, Yin-Jian Sun, Lin Yang, Shile Huang, Yi-Jun Wu. Avermectin induces P-glycoprotein expression in S2 cells via the calcium/calmodulin/NF-κB pathway.
Chemico-biological interactions.
2013 Apr; 203(2):430-9. doi:
10.1016/j.cbi.2013.03.009. [PMID: 23523950] - Elisabetta Albi, Andrea Lazzarini, Remo Lazzarini, Alessandro Floridi, Eleni Damaskopoulou, Francesco Curcio, Samuela Cataldi. Nuclear lipid microdomain as place of interaction between sphingomyelin and DNA during liver regeneration.
International journal of molecular sciences.
2013 Mar; 14(4):6529-41. doi:
10.3390/ijms14046529. [PMID: 23528885] - Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Ching-Chung Tsai, Shih-Che Huang, Jong-Kang Liu, Hsiu-Chuan Wang, Tong-Rong Tsai, Ping-Ju Tsai, Ching-Wen Liu, Li-Ching Chang. Salvia miltiorrhiza causes tonic contraction in rat ileum through Ca²⁺-calmodulin pathway.
Journal of ethnopharmacology.
2012 Aug; 142(3):694-9. doi:
10.1016/j.jep.2012.05.041. [PMID: 22683910] - Shohana Parvin, Ok Ran Lee, Gayathri Sathiyaraj, Altanzul Khorolragchaa, Yu-Jin Kim, Balusamy Sri Renuka Devi, Deok-Chun Yang. Interrelationship between calmodulin (CaM) and H2O2 in abscisic acid-induced antioxidant defense in the seedlings of Panax ginseng.
Molecular biology reports.
2012 Jul; 39(7):7327-38. doi:
10.1007/s11033-012-1564-5. [PMID: 22307798] - Martin González-Andrade, Elena Benito-Peña, Rachel Mata, Maria C Moreno-Bondi. Biosensor for on-line fluorescent detection of trifluoroperazine based on genetically modified calmodulin.
Analytical and bioanalytical chemistry.
2012 Apr; 402(10):3211-8. doi:
10.1007/s00216-011-5701-0. [PMID: 22331049] - Zhong-Guang Li, Ming Gong, Hong Xie, Lan Yang, Jing Li. Hydrogen sulfide donor sodium hydrosulfide-induced heat tolerance in tobacco (Nicotiana tabacum L) suspension cultured cells and involvement of Ca(2+) and calmodulin.
Plant science : an international journal of experimental plant biology.
2012 Apr; 185-186(?):185-9. doi:
10.1016/j.plantsci.2011.10.006. [PMID: 22325880] - Meeta J Advani, Imran Siddiqui, Pawan Sharma, Hemalatha Reddy. Activity of trifluoperazine against replicating, non-replicating and drug resistant M. tuberculosis.
PloS one.
2012; 7(8):e44245. doi:
10.1371/journal.pone.0044245. [PMID: 22952939] - Gajanan B Zore, Archana D Thakre, Sitaram Jadhav, S Mohan Karuppayil. Terpenoids inhibit Candida albicans growth by affecting membrane integrity and arrest of cell cycle.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2011 Oct; 18(13):1181-90. doi:
10.1016/j.phymed.2011.03.008. [PMID: 21596542] - Mohamed-Eslam F Mohamed, Reginald F Frye. Inhibitory effects of commonly used herbal extracts on UDP-glucuronosyltransferase 1A4, 1A6, and 1A9 enzyme activities.
Drug metabolism and disposition: the biological fate of chemicals.
2011 Sep; 39(9):1522-8. doi:
10.1124/dmd.111.039602. [PMID: 21632963] - Ana I Loureiro, Carlos Fernandes-Lopes, Maria J Bonifácio, Lyndon C Wright, Patricio Soares-da-Silva. Hepatic UDP-glucuronosyltransferase is responsible for eslicarbazepine glucuronidation.
Drug metabolism and disposition: the biological fate of chemicals.
2011 Sep; 39(9):1486-94. doi:
10.1124/dmd.111.038620. [PMID: 21673130] - Raffaele Longhi, Silvia Corbioli, Stefano Fontana, Federicia Vinco, Simone Braggio, Lydia Helmdach, Jürgen Schiller, Hinnerk Boriss. Brain tissue binding of drugs: evaluation and validation of solid supported porcine brain membrane vesicles (TRANSIL) as a novel high-throughput method.
Drug metabolism and disposition: the biological fate of chemicals.
2011 Feb; 39(2):312-21. doi:
10.1124/dmd.110.036095. [PMID: 21071520] - Olga Wesołowska, Krystyna Michalak, Andrzej B Hendrich. Direct visualization of phase separation induced by phenothiazine-type antipsychotic drugs in model lipid membranes.
Molecular membrane biology.
2011 Feb; 28(2):103-14. doi:
10.3109/09687688.2010.533706. [PMID: 21190429] - Shaghayegh Bazhdanzadeh, Zahra Talebpour, Noushin Adib, Hassan Y Aboul-Enein. A simple and reliable stir bar sorptive extraction-liquid chromatography procedure for the determination of chlorpromazine and trifluoperazine in human serum using experimental design methodology.
Journal of separation science.
2011 Jan; 34(1):90-7. doi:
10.1002/jssc.201000649. [PMID: 21171181] - Zihui Liu, Zhenyu Ma, Xiulin Guo, Hongbo Shao, Qiuhua Cui, Weiyi Song. Changes of cytosolic Ca(2+) fluorescence intensity and plasma membrane calcium channels of maize root tip cells under osmotic stress.
Plant physiology and biochemistry : PPB.
2010 Oct; 48(10-11):860-5. doi:
10.1016/j.plaphy.2010.08.008. [PMID: 20843698] - Varsha Gupta, Ansuman Roy, Baishnab C Tripathy. Signaling events leading to red-light-induced suppression of photomorphogenesis in wheat (Triticum aestivum).
Plant & cell physiology.
2010 Oct; 51(10):1788-99. doi:
10.1093/pcp/pcq139. [PMID: 20823341] - Li Wang, Min Liu, Ying Guo Lv, Hui Zhang. Purification of calmodulin from rice bran and activation of glutamate decarboxylase by Ca2+/calmodulin.
Journal of the science of food and agriculture.
2010 Mar; 90(4):669-75. doi:
10.1002/jsfa.3866. [PMID: 20355097] - Sunaina Koul, Aruna Somayajulu, Meeta J Advani, Hemalatha Reddy. A novel calcium binding protein in Mycobacterium tuberculosis--potential target for trifluoperazine.
Indian journal of experimental biology.
2009 Jun; 47(6):480-8. doi:
. [PMID: 19639701] - Anna Anielska-Mazur, Tytus Bernaś, Halina Gabryś. In vivo reorganization of the actin cytoskeleton in leaves of Nicotiana tabacum L. transformed with plastin-GFP. Correlation with light-activated chloroplast responses.
BMC plant biology.
2009 May; 9(?):64. doi:
10.1186/1471-2229-9-64. [PMID: 19480655] - Marcin Kolaczkowski, Anna Kolaczkowska, Noboru Motohashi, Krystyna Michalak. New high-throughput screening assay to reveal similarities and differences in inhibitory sensitivities of multidrug ATP-binding cassette transporters.
Antimicrobial agents and chemotherapy.
2009 Apr; 53(4):1516-27. doi:
10.1128/aac.00956-08. [PMID: 19188399] - Tong Chen, Xiaoqin Wu, Yanmei Chen, Xiaojuan Li, Mei Huang, Maozhong Zheng, Frantisek Baluska, Jozef Samaj, Jinxing Lin. Combined proteomic and cytological analysis of Ca2+-calmodulin regulation in Picea meyeri pollen tube growth.
Plant physiology.
2009 Feb; 149(2):1111-26. doi:
10.1104/pp.108.127514. [PMID: 19011005] - Joseph Molnár, Meltem Demirel Kars, Ufuk Gündüz, Helga Engi, Udo Schumacher, Els J Van Damme, Willy J Peumans, Josef Makovitzky, Nóra Gyémánt, Péter Molnár. Interaction of tomato lectin with ABC transporter in cancer cells: glycosylation confers functional conformation of P-gp.
Acta histochemica.
2009; 111(4):329-33. doi:
10.1016/j.acthis.2008.11.010. [PMID: 19124148] - Marco Tafani, Luana Schito, Tahira Anwar, Manuela Indelicato, Patrizio Sale, Maura Di Vito, Emanuela Morgante, Rosanna Beraldi, Francesco Makovec, Ornella Letari, Gianfranco Caselli, Corrado Spadafora, Bruna Pucci, Matteo A Russo. Induction of autophagic cell death by a novel molecule is increased by hypoxia.
Autophagy.
2008 Nov; 4(8):1042-53. doi:
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Biochimica et biophysica acta.
2008 Oct; 1778(10):2165-76. doi:
10.1016/j.bbamem.2008.04.007. [PMID: 18503745] - Martin P Boland, David A Middleton. The dynamics and orientation of a lipophilic drug within model membranes determined by 13C solid-state NMR.
Physical chemistry chemical physics : PCCP.
2008 Jan; 10(1):178-85. doi:
10.1039/b712892d. [PMID: 18075697] - Abubakr M Idris. On-line coupling of solid-phase extraction, derivatization reaction and spectrophotometry by sequential injection analysis: application to trifluoperazine assay in human urine.
Journal of pharmacological and toxicological methods.
2007 Nov; 56(3):330-5. doi:
10.1016/j.vascn.2007.08.005. [PMID: 17897843] - Micah D Zuccarelli, Rolf L Ingermann. Calcium-induced quiescence of sperm motility in the bluegill (Lepomis macrochirus).
Journal of experimental zoology. Part A, Ecological genetics and physiology.
2007 Oct; 307(10):590-9. doi:
10.1002/jez.414. [PMID: 17724674] - Virgilio L Lew, Nuala Daw, Zipora Etzion, Teresa Tiffert, Adaeze Muoma, Laura Vanagas, Robert M Bookchin. Effects of age-dependent membrane transport changes on the homeostasis of senescent human red blood cells.
Blood.
2007 Aug; 110(4):1334-42. doi:
10.1182/blood-2006-11-057232. [PMID: 17456724] - Wei Tang, Jinxing Lin, Ronald J Newton. Okadaic acid and trifluoperazine enhance Agrobacterium-mediated transformation in eastern white pine.
Plant cell reports.
2007 May; 26(5):673-82. doi:
10.1007/s00299-006-0270-y. [PMID: 17242943] - Patricia Souza dos Santos, Dayvison Francis Saraiva, Danielly Cristiny Ferraz da Costa, Helena Maria Scofano, Paulo Cesar de Carvalho-Alves. Trifluoperazine protects brain plasma membrane Ca(2+)-ATPase from oxidative damaging.
Experimental brain research.
2007 Mar; 177(3):347-57. doi:
10.1007/s00221-006-0678-1. [PMID: 16955267] - Agnieszka Broniec, Anja Underhaug Gjerde, Anne Berit Ølmheim, Holm Holmsen. Trifluoperazine causes a disturbance in glycerophospholipid monolayers containing phosphatidylserine (PS): effects of pH, acyl unsaturation, and proportion of PS.
Langmuir : the ACS journal of surfaces and colloids.
2007 Jan; 23(2):694-9. doi:
10.1021/la061628b. [PMID: 17209622] - Wan-Qin Xie, Li-Qing Zhao, Wen-Yan Bai, Zhen-Peng Li, Yu-Long Zhao, Cui-Feng Li. [The effects of calmodulin on the lipid-binding activity of CaM-binding protein-10 and maize non-specific lipid transfer protein].
Zhi wu sheng li yu fen zi sheng wu xue xue bao = Journal of plant physiology and molecular biology.
2006 Dec; 32(6):679-84. doi:
". [PMID: 17167205] - Olga A Akimova, Alexandra Grygorczyk, Richard A Bundey, Nathalie Bourcier, Michael Gekle, Paul A Insel, Sergei N Orlov. Transient activation and delayed inhibition of Na+,K+,Cl- cotransport in ATP-treated C11-MDCK cells involve distinct P2Y receptor subtypes and signaling mechanisms.
The Journal of biological chemistry.
2006 Oct; 281(42):31317-25. doi:
10.1074/jbc.m602117200. [PMID: 16916802] - Verawan Uchaipichat, Leanne K Winner, Peter I Mackenzie, David J Elliot, J Andrew Williams, John O Miners. Quantitative prediction of in vivo inhibitory interactions involving glucuronidated drugs from in vitro data: the effect of fluconazole on zidovudine glucuronidation.
British journal of clinical pharmacology.
2006 Apr; 61(4):427-39. doi:
10.1111/j.1365-2125.2006.02588.x. [PMID: 16542204] - Prathama Guha, Krishna Roy, Debashis Sanyal, Tirthankar Dasgupta, Kaberi Bhattacharya. Olanzapine-induced obesity and diabetes in Indian patients: a prospective trial comparing olanzapine with typical antipsychotics.
Journal of the Indian Medical Association.
2005 Dec; 103(12):660-4. doi:
NULL. [PMID: 16821658] - Zhong-Guang Li, Chao-Kun Du, Ming Gong. [Involvement of Ca2+ and calmodulin in the regulation of H2O2-induced heat tolerance in maize seedlings].
Zhi wu sheng li yu fen zi sheng wu xue xue bao = Journal of plant physiology and molecular biology.
2005 Oct; 31(5):515-9. doi:
NULL. [PMID: 16222094] - Yuki Fujiki, Yuka Nakagawa, Tsuyoshi Furumoto, Satoko Yoshida, Basanti Biswal, Masaki Ito, Akira Watanabe, Ikuo Nishida. Response to darkness of late-responsive dark-inducible genes is positively regulated by leaf age and negatively regulated by calmodulin-antagonist-sensitive signalling in Arabidopsis thaliana.
Plant & cell physiology.
2005 Oct; 46(10):1741-6. doi:
10.1093/pcp/pci174. [PMID: 16100230] - Cengiz Tuglu, Esin Erdogan, Ercan Abay. Delirium and extrapyramidal symptoms due to a lithium-olanzapine combination therapy: a case report.
Journal of Korean medical science.
2005 Aug; 20(4):691-4. doi:
10.3346/jkms.2005.20.4.691. [PMID: 16100469] - Jason D Hoffert, Chung-Lin Chou, Robert A Fenton, Mark A Knepper. Calmodulin is required for vasopressin-stimulated increase in cyclic AMP production in inner medullary collecting duct.
The Journal of biological chemistry.
2005 Apr; 280(14):13624-30. doi:
10.1074/jbc.m500040200. [PMID: 15710610] - Krishnaswamy Balamurugan, Nosratola D Vaziri, Hamid M Said. Biotin uptake by human proximal tubular epithelial cells: cellular and molecular aspects.
American journal of physiology. Renal physiology.
2005 Apr; 288(4):F823-31. doi:
10.1152/ajprenal.00375.2004. [PMID: 15561972] - Hidefumi Kaji, Toshiyuki Kume. Characterization of afloqualone N-glucuronidation: species differences and identification of human UDP-glucuronosyltransferase isoform(s).
Drug metabolism and disposition: the biological fate of chemicals.
2005 Jan; 33(1):60-7. doi:
10.1124/dmd.104.001925. [PMID: 15475412] - M Yamaguchi, M Fukagawa. Role of zinc in regulation of protein tyrosine phosphatase activity in osteoblastic MC3T3-E1 cells: zinc modulation of insulin-like growth factor-I's effect.
Calcified tissue international.
2005 Jan; 76(1):32-8. doi:
10.1007/s00223-004-0052-x. [PMID: 15477998] - Thai-Yen Ling, Chun-Lin Chen, Yen-Hua Huang, I-Hua Liu, Shuan Shian Huang, Jung San Huang. Identification and characterization of the acidic pH binding sites for growth regulatory ligands of low density lipoprotein receptor-related protein-1.
The Journal of biological chemistry.
2004 Sep; 279(37):38736-48. doi:
10.1074/jbc.m310537200. [PMID: 15226301] - Soon Young Shin, Chang Gun Kim, Dong Dae Hong, Jung-Hye Kim, Young Han Lee. Implication of Egr-1 in trifluoperazine-induced growth inhibition in human U87MG glioma cells.
Experimental & molecular medicine.
2004 Aug; 36(4):380-6. doi:
10.1038/emm.2004.50. [PMID: 15365258] - Syujirou Matsuyama, Tsuneo Kitamura, Nobuyuki Enomoto, Toshiko Fujita, Akihito Ishigami, Setsuko Handa, Naoki Maruyama, Dongmei Zheng, Kenichi Ikejima, Yoshiyuki Takei, Nobuhiro Sato. Senescence marker protein-30 regulates Akt activity and contributes to cell survival in Hep G2 cells.
Biochemical and biophysical research communications.
2004 Aug; 321(2):386-90. doi:
10.1016/j.bbrc.2004.06.161. [PMID: 15358188] - David A Middleton, Eleri Hughes, Jillian Madine. Screening molecular associations with lipid membranes using natural abundance 13C cross-polarization magic-angle spinning NMR and principal component analysis.
Journal of the American Chemical Society.
2004 Aug; 126(31):9478-9. doi:
10.1021/ja048226f. [PMID: 15291517] - Claire M Peppiatt, Anthony M Holmes, Jeong T Seo, Martin D Bootman, Tony J Collins, Fraser McDonald, H Llewelyn Roderick. Calmidazolium and arachidonate activate a calcium entry pathway that is distinct from store-operated calcium influx in HeLa cells.
The Biochemical journal.
2004 Aug; 381(Pt 3):929-39. doi:
10.1042/bj20040097. [PMID: 15130089] - Kartiki Bhatnagar, Ved Pal Singh. Ca2+ dependence and inhibitory effects of trifluoperazine on plasma membrane ATPase of Thermoactinomyces vulgaris.
Current microbiology.
2004 Jul; 49(1):28-31. doi:
10.1007/s00284-003-4261-8. [PMID: 15297926] - Indrajit Sinha, Thomas Dick. Role for malonyl coenzyme A:acyl carrier protein transacylase (MCAT) in the growth-inhibitory effect of the calmodulin antagonist trifluoperazine in Mycobacterium bovis BCG.
The Journal of antimicrobial chemotherapy.
2004 Jun; 53(6):1072-5. doi:
10.1093/jac/dkh241. [PMID: 15150177] - A A Hidalgo, W Caetano, M Tabak, O N Oliveira. Interaction of two phenothiazine derivatives with phospholipid monolayers.
Biophysical chemistry.
2004 Apr; 109(1):85-104. doi:
10.1016/j.bpc.2003.10.020. [PMID: 15059662] - Nirianne Marie Q Palacpac, Yasushi Hiramine, Fumika Mi-ichi, Motomi Torii, Kiyoshi Kita, Ryuji Hiramatsu, Toshihiro Horii, Toshihide Mitamura. Developmental-stage-specific triacylglycerol biosynthesis, degradation and trafficking as lipid bodies in Plasmodium falciparum-infected erythrocytes.
Journal of cell science.
2004 Mar; 117(Pt 8):1469-80. doi:
10.1242/jcs.00988. [PMID: 15020675] - Horng-Huey Ko, Jing-Ru Weng, Lo-Ti Tsao, Ming-Hong Yen, Jih-Pyang Wang, Chun-Nan Lin. Anti-inflammatory flavonoids and pterocarpanoid from Crotalaria pallida and C. assamica.
Bioorganic & medicinal chemistry letters.
2004 Feb; 14(4):1011-4. doi:
10.1016/j.bmcl.2003.11.074. [PMID: 15013012] - Zhong Jie Ma, Masayoshi Yamaguchi. Regulatory effect of regucalcin on nitric oxide synthase activity in rat kidney cortex cytosol: Role of endogenous regucalcin in transgenic rats.
International journal of molecular medicine.
2003 Aug; 12(2):201-6. doi:
. [PMID: 12851718] - Takako Izumi, Yoshinori Tsurusaki, Masayoshi Yamaguchi. Suppressive effect of endogenous regucalcin on nitric oxide synthase activity in cloned rat hepatoma H4-II-E cells overexpressing regucalcin.
Journal of cellular biochemistry.
2003 Jul; 89(4):800-7. doi:
10.1002/jcb.10544. [PMID: 12858345] - Ying-Dai Gao, Dong-Sheng Xiong, Yuan-Fu Xu, Hui Peng, Xiao-Feng Shao, Chun-Zheng Yang, Zhen-Ping Zhu. [Construction and expression of anti-CD3/ anti-Pgp Diabody].
Sheng wu gong cheng xue bao = Chinese journal of biotechnology.
2003 Jul; 19(4):444-9. doi:
NULL. [PMID: 15969062] - Tatsuru Masuda, Ayumi Tanaka, Anastasios Melis. Chlorophyll antenna size adjustments by irradiance in Dunaliella salina involve coordinate regulation of chlorophyll a oxygenase (CAO) and Lhcb gene expression.
Plant molecular biology.
2003 Mar; 51(5):757-71. doi:
10.1023/a:1022545118212. [PMID: 12678561] - Jing-Ru Weng, Lo-Ti Tsao, Ming-Hong Yen, Jih-Pyang Wang, Chun-Nan Lin. Anti-inflammatory constituents and new pterocarpanoid of Crotalaria pallida.
Journal of natural products.
2003 Mar; 66(3):404-7. doi:
10.1021/np020135d. [PMID: 12662101] - Sertac N Kip, Emanuel E Strehler. Characterization of PMCA isoforms and their contribution to transcellular Ca2+ flux in MDCK cells.
American journal of physiology. Renal physiology.
2003 Jan; 284(1):F122-32. doi:
10.1152/ajprenal.00161.2002. [PMID: 12388403] - Howard S Judelson, Samuel Roberts. Novel protein kinase induced during sporangial cleavage in the oomycete Phytophthora infestans.
Eukaryotic cell.
2002 Oct; 1(5):687-95. doi:
10.1128/ec.1.5.687-695.2002. [PMID: 12455688] - Hosakere D Revanasiddappa, Telangusadhushetty N Kiran Kumar. A simple and rapid spectrophotometric determination of thallium(III) with trifluoperazine hydrochloride.
Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.
2002 Oct; 18(10):1131-5. doi:
10.2116/analsci.18.1131. [PMID: 12400660] - Manoj G Pillai, Ateeque Ahmad, Toshihiro Yokochi, Toro Nakahara, Yasushi Kamisaka. Biosynthesis of triacylglycerol molecular species in an oleaginous fungus, Mortierella ramanniana var. angulispora.
Journal of biochemistry.
2002 Jul; 132(1):121-6. doi:
10.1093/oxfordjournals.jbchem.a003188. [PMID: 12097168] - Ewa Landwojtowicz, Pierluigi Nervi, Anna Seelig. Real-time monitoring of P-glycoprotein activation in living cells.
Biochemistry.
2002 Jun; 41(25):8050-7. doi:
10.1021/bi025720s. [PMID: 12069596] - Tiago Rodrigues, Antonio C Santos, Acácio A Pigoso, Fábio E Mingatto, Sérgio A Uyemura, Carlos Curti. Thioridazine interacts with the membrane of mitochondria acquiring antioxidant activity toward apoptosis--potentially implicated mechanisms.
British journal of pharmacology.
2002 May; 136(1):136-42. doi:
10.1038/sj.bjp.0704672. [PMID: 11976278] - Philip Seeman. Atypical antipsychotics: mechanism of action.
Canadian journal of psychiatry. Revue canadienne de psychiatrie.
2002 Feb; 47(1):27-38. doi:
. [PMID: 11873706] - Ximena Ortega, Rubén Polanco, Patricia Castañeda, Luz M Perez. Signal transduction in lemon seedlings in the hypersensitive response against Alternaria alternata: participation of calmodulin, G-protein and protein kinases.
Biological research.
2002; 35(3-4):373-83. doi:
10.4067/s0716-97602002000300012. [PMID: 12462990] - K R Kang, S Y Lee. Effect of serum and hydrogen peroxide on the Ca2+/calmodulin-dependent phosphorylation of eukaryotic elongation factor 2(eEF-2) in Chinese hamster ovary cells.
Experimental & molecular medicine.
2001 Dec; 33(4):198-204. doi:
10.1038/emm.2001.33. [PMID: 11795480]
