methoxamine (BioDeep_00000405899)

Main id: BioDeep_00000003140

 

natural product


代谢物信息卡片


methoxamine

化学式: C11H17NO3 (211.1208)
中文名称: 甲氧明
谱图信息: 最多检出来源 Homo sapiens(blood) 14.22%

分子结构信息

SMILES: CC(C(C1=C(C=CC(=C1)OC)OC)O)N
InChI: InChI=1S/C11H17NO3/c1-7(12)11(13)9-6-8(14-2)4-5-10(9)15-3/h4-7,11,13H,12H2,1-3H3

描述信息

C - Cardiovascular system > C01 - Cardiac therapy > C01C - Cardiac stimulants excl. cardiac glycosides > C01CA - Adrenergic and dopaminergic agents
D018373 - Peripheral Nervous System Agents > D001337 - Autonomic Agents > D013566 - Sympathomimetics
D018377 - Neurotransmitter Agents > D018663 - Adrenergic Agents > D000322 - Adrenergic Agonists
D002317 - Cardiovascular Agents > D014662 - Vasoconstrictor Agents

同义名列表

2 个代谢物同义名

methoxamine; Methoxamine



数据库引用编号

31 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 9 ADA, ADRA1A, AXIN2, CACNA1A, EDN1, ITPR3, NOS3, PRKX, RHOA
Peripheral membrane protein 1 ADA
Endoplasmic reticulum membrane 2 ITPR3, RHOA
Nucleus 7 ADRA1A, AXIN2, CACNA1A, NOS3, PLCZ1, PRKX, RHOA
cytosol 9 ADA, ADRA1A, AVP, AXIN2, NOS3, PLCZ1, PRKCQ, RHOA, SST
dendrite 1 AVP
centrosome 1 AXIN2
nucleoplasm 5 ADRA1A, ITPR3, NOS3, PLCZ1, PRKX
Cell membrane 5 ADA, ADRA1A, ADRB3, CACNA1A, RHOA
Lipid-anchor 1 RHOA
Cytoplasmic side 1 RHOA
Cleavage furrow 1 RHOA
lamellipodium 1 RHOA
ruffle membrane 1 RHOA
Multi-pass membrane protein 6 ADRA1A, ADRB3, CACNA1A, CACNA1I, ITPR3, KCNA3
Synapse 2 CACNA1A, TAC1
cell cortex 1 RHOA
cell junction 2 ADA, RHOA
cell surface 1 ADA
glutamatergic synapse 2 KCNA3, RHOA
Golgi apparatus 1 NOS3
Golgi membrane 2 INS, NOS3
neuronal cell body 4 CACNA1A, ITPR3, SST, TAC1
postsynapse 1 RHOA
presynaptic membrane 1 KCNA3
Lysosome 1 ADA
endosome 1 RHOA
plasma membrane 13 ADA, ADRA1A, ADRB3, AXIN2, CACNA1A, CACNA1I, ITPR3, KCNA3, KNG1, NOS3, PRKCQ, REN, RHOA
Membrane 6 ADA, CACNA1A, CACNA1I, ITPR3, KCNA3, REN
axon 2 KCNA3, TAC1
brush border 1 ITPR3
caveola 2 ADRA1A, NOS3
extracellular exosome 2 KNG1, RHOA
endoplasmic reticulum 1 ITPR3
extracellular space 7 AVP, EDN1, INS, KNG1, REN, SST, TAC1
perinuclear region of cytoplasm 3 KCNA3, NOS3, PLCZ1
intracellular membrane-bounded organelle 1 ADRA1A
pronucleus 1 PLCZ1
Secreted 5 AVP, EDN1, INS, REN, SST
extracellular region 7 AVP, EDN1, INS, KNG1, REN, SST, TAC1
cytoplasmic side of plasma membrane 1 RHOA
basal part of cell 1 EDN1
Extracellular side 1 ADA
Cytoplasmic vesicle lumen 1 ADA
anchoring junction 1 ADA
centriolar satellite 1 PRKCQ
Nucleus membrane 1 ADRA1A
nuclear membrane 1 ADRA1A
external side of plasma membrane 1 ADA
dendritic spine 1 RHOA
beta-catenin destruction complex 1 AXIN2
nucleolus 2 ITPR3, PLCZ1
midbody 1 RHOA
Cytoplasm, P-body 1 NOS3
P-body 1 NOS3
apical part of cell 2 ITPR3, REN
vesicle 1 RHOA
postsynaptic membrane 1 KCNA3
Cell projection, lamellipodium 1 RHOA
Cytoplasm, perinuclear region 1 PLCZ1
Membrane raft 1 KCNA3
focal adhesion 1 RHOA
GABA-ergic synapse 1 SST
sarcoplasmic reticulum 1 ITPR3
collagen-containing extracellular matrix 1 KNG1
secretory granule 1 AVP
nuclear outer membrane 1 ITPR3
receptor complex 2 ADRB3, ITPR3
cell projection 1 CACNA1A
cell periphery 1 RHOA
cytoskeleton 2 NOS3, RHOA
Secreted, extracellular space 1 KNG1
Cytoplasm, cell cortex 1 RHOA
blood microparticle 1 KNG1
[Isoform 2]: Cell membrane 1 KCNA3
endosome lumen 1 INS
Membrane, caveola 1 ADRA1A
monoatomic ion channel complex 1 CACNA1A
Cell projection, dendrite 1 RHOA
Cytoplasm, Stress granule 1 NOS3
cytoplasmic stress granule 1 NOS3
voltage-gated potassium channel complex 1 KCNA3
secretory granule lumen 1 INS
secretory granule membrane 2 ITPR3, RHOA
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 INS, KNG1
platelet alpha granule lumen 1 KNG1
voltage-gated calcium channel complex 2 CACNA1A, CACNA1I
endocytic vesicle membrane 1 NOS3
transport vesicle 2 EDN1, INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
neuronal dense core vesicle 2 AVP, SST
aggresome 1 PRKCQ
calyx of Held 1 KCNA3
clathrin-coated endocytic vesicle membrane 1 AVP
platelet dense tubular network membrane 1 ITPR3
ficolin-1-rich granule membrane 1 RHOA
apical junction complex 1 RHOA
[Isoform 1]: Cell membrane 1 KCNA3
Cytoplasmic vesicle, secretory vesicle membrane 1 ITPR3
transport vesicle membrane 1 ITPR3
rough endoplasmic reticulum lumen 1 EDN1
sperm head 1 PLCZ1
Weibel-Palade body 1 EDN1
cytoplasmic side of endoplasmic reticulum membrane 1 ITPR3
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Gustavo de-Los-Santos-Cocotle, Juan Carlos Martínez-Morales, M Teresa Romero-Ávila, Guadalupe Reyes-Cruz, J Adolfo García-Sáinz. Effects of agonists and phorbol esters on α1A-adrenergic receptor-Rab protein interactions. European journal of pharmacology. 2020 Oct; 885(?):173423. doi: 10.1016/j.ejphar.2020.173423. [PMID: 32750368]
  • Xiaowei Guo, Jie Hu, Hanbing Xiao, Tianyu Liu, Zheng Niu, Min Wang, Dunyi Qi. Effect of continuous intraoperative infusion of methoxamine on renal function in elderly patients undergoing gastrointestinal tumor surgery: a randomized controlled trial. BMC anesthesiology. 2020 06; 20(1):148. doi: 10.1186/s12871-020-01064-0. [PMID: 32534584]
  • Qian Qin, Disheng Feng, Chunxiu Hu, Bohong Wang, Mengmeng Chang, Xinyu Liu, Peiyuan Yin, Xianzhe Shi, Guowang Xu. Parallel derivatization strategy coupled with liquid chromatography-mass spectrometry for broad coverage of steroid hormones. Journal of chromatography. A. 2020 Mar; 1614(?):460709. doi: 10.1016/j.chroma.2019.460709. [PMID: 31784081]
  • Maki Kotaka, Taro Toyoda, Katsutaro Yasuda, Yuko Kitano, Chihiro Okada, Akira Ohta, Akira Watanabe, Motonari Uesugi, Kenji Osafune. Adrenergic receptor agonists induce the differentiation of pluripotent stem cell-derived hepatoblasts into hepatocyte-like cells. Scientific reports. 2017 12; 7(1):16734. doi: 10.1038/s41598-017-16858-5. [PMID: 29196668]
  • S Afzal, M A Sattar, Edward J Johns, Mohammed H Abdulla, Safia Akhtar, Fayyaz Hashmi, Nor Azizan Abdullah. Interaction between irbesartan, peroxisome proliferator-activated receptor (PPAR-γ), and adiponectin in the regulation of blood pressure and renal function in spontaneously hypertensive rats. Journal of physiology and biochemistry. 2016 Dec; 72(4):593-604. doi: 10.1007/s13105-016-0497-1. [PMID: 27405250]
  • Kai Y Mak, Ruth Chin, Sharon C Cunningham, Miriam R Habib, Joseph Torresi, Alexandra F Sharland, Ian E Alexander, Peter W Angus, Chandana B Herath. ACE2 Therapy Using Adeno-associated Viral Vector Inhibits Liver Fibrosis in Mice. Molecular therapy : the journal of the American Society of Gene Therapy. 2015 Sep; 23(9):1434-43. doi: 10.1038/mt.2015.92. [PMID: 25997428]
  • Ashfaq Ahmad, Munavvar A Sattar, Hassaan A Rathore, Mohammad H Abdulla, Safia A Khan, Nor A Abdullah, Gurjeet Kaur, Edward J Johns. Functional contribution of α1D-adrenoceptors in the renal vasculature of left ventricular hypertrophy induced with isoprenaline and caffeine in Wistar-Kyoto rats. Canadian journal of physiology and pharmacology. 2014 Dec; 92(12):1029-35. doi: 10.1139/cjpp-2014-0236. [PMID: 25403946]
  • Defeng Sun, Yue Wu, Lin Yang, Jun Han, Ruochuan Liu, Lijie Wang. Effects of continuous intravenous infusion of methoxamine on the intraoperative hemodynamics of elderly patients undergoing total hip arthroplasty. Medical science monitor : international medical journal of experimental and clinical research. 2014 Oct; 20(?):1969-76. doi: 10.12659/msm.890760. [PMID: 25326008]
  • L Siproudhis, D Jones, R Ng Kwet Shing, D Walker, J H Scholefield. Libertas: rationale and study design of a multicentre, Phase II, double-blind, randomised, placebo-controlled investigation to evaluate the efficacy, safety and tolerability of locally applied NRL001 in patients with faecal incontinence. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland. 2014 Mar; 16 Suppl 1(?):59-66. doi: 10.1111/codi.12546. [PMID: 24499497]
  • D Bell, A Duffin, H J Gruss, C Pediconi, A Jacobs. A randomised, controlled, crossover study to investigate the pharmacodynamics, pharmacokinetics and safety of 1R,2S-methoxamine hydrochloride (NRL001) in healthy elderly subjects. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland. 2014 Mar; 16 Suppl 1(?):27-35. doi: 10.1111/codi.12543. [PMID: 24499494]
  • J A D Simpson, D Bush, H J Gruss, A Jacobs, C Pediconi, J H Scholefield. A randomised, controlled, crossover study to investigate the safety and response of 1R,2S-methoxamine hydrochloride (NRL001) on anal function in healthy volunteers. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland. 2014 Mar; 16 Suppl 1(?):5-15. doi: 10.1111/codi.12541. [PMID: 24499492]
  • D Bell, A Duffin, A Jacobs, C Pediconi, H J Gruss. A double-blind, placebo-controlled, randomised, parallel-group, dose-escalating, repeat dose study in healthy volunteers to evaluate the safety, tolerability, pharmacodynamic effects and pharmacokinetics of the once daily rectal application of NRL001 suppositories for 14 days. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland. 2014 Mar; 16 Suppl 1(?):36-50. doi: 10.1111/codi.12544. [PMID: 24499495]
  • Sevgi Tatar Ulu. Determination of methoxamine in human plasma and urine by a validated HPLC-fluorescence detection method. Journal of AOAC International. 2013 Sep; 96(5):987-90. doi: 10.5740/jaoacint.10-479. [PMID: 24282936]
  • Daniel J Warner, Hongming Chen, Louis-David Cantin, J Gerry Kenna, Simone Stahl, Clare L Walker, Tobias Noeske. Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification. Drug metabolism and disposition: the biological fate of chemicals. 2012 Dec; 40(12):2332-41. doi: 10.1124/dmd.112.047068. [PMID: 22961681]
  • Punnee Nusuetrong, Uthai Sotanaphun, Patcharin Tep-Areenan. Effects of Phikud Navakot extract on vascular reactivity in the isolated rat aorta. Journal of the Medical Association of Thailand = Chotmaihet thangphaet. 2012 Dec; 95 Suppl 12(?):S1-7. doi: . [PMID: 23513458]
  • Sven Francque, Wim Laleman, Len Verbeke, Christophe Van Steenkiste, Christophe Casteleyn, Wilhelmus Kwanten, Christophe Van Dyck, Michiel D'Hondt, Albert Ramon, Wim Vermeulen, Benedicte De Winter, Eric Van Marck, Veerle Van Marck, Paul Pelckmans, Peter Michielsen. Increased intrahepatic resistance in severe steatosis: endothelial dysfunction, vasoconstrictor overproduction and altered microvascular architecture. Laboratory investigation; a journal of technical methods and pathology. 2012 Oct; 92(10):1428-39. doi: 10.1038/labinvest.2012.103. [PMID: 22890552]
  • Mohammed H Abdulla, Munavvar A Sattar, Nor A Abdullah, Edward J Johns. The effect of losartan and carvedilol on renal haemodynamics and altered metabolism in fructose-fed Sprague-Dawley rats. Journal of physiology and biochemistry. 2012 Sep; 68(3):353-63. doi: 10.1007/s13105-012-0147-1. [PMID: 22281695]
  • Mohammed H Abdulla, Munavvar A Sattar, Edward J Johns, Nor A Abdullah, Md Abdul Hye Khan, Hassaan A Rathore. High-fructose feeding impacts on the adrenergic control of renal haemodynamics in the rat. The British journal of nutrition. 2012 Jan; 107(2):218-28. doi: 10.1017/s0007114511002716. [PMID: 21733307]
  • Ying-Ying Yang, Tzung-Yan Lee, Yi-Tsau Huang, Che-Chang Chan, Yi-Chen Yeh, Fa-Yauh Lee, Shou-Dong Lee, Han-Chieh Lin. Asymmetric dimethylarginine (ADMA) determines the improvement of hepatic endothelial dysfunction by vitamin E in cirrhotic rats. Liver international : official journal of the International Association for the Study of the Liver. 2012 Jan; 32(1):48-57. doi: 10.1111/j.1478-3231.2011.02651.x. [PMID: 22098317]
  • Mohammed H Abdulla, Munavvar A Sattar, Edward J Johns, Nor A Abdullah, Md Abdul Hye Khan. Evidence for the role of α1A-adrenoceptor subtype in the control of renal haemodynamics in fructose-fed Sprague-Dawley rat. European journal of nutrition. 2011 Dec; 50(8):689-97. doi: 10.1007/s00394-011-0180-9. [PMID: 21373947]
  • Clara Sciorati, Daniela Miglietta, Roberta Buono, Viviana Pisa, Dario Cattaneo, Emanuele Azzoni, Silvia Brunelli, Emilio Clementi. A dual acting compound releasing nitric oxide (NO) and ibuprofen, NCX 320, shows significant therapeutic effects in a mouse model of muscular dystrophy. Pharmacological research. 2011 Sep; 64(3):210-7. doi: 10.1016/j.phrs.2011.05.003. [PMID: 21609764]
  • Mohammed H Abdulla, Munavvar A Sattar, Nor A Abdullah, Md Abdul Hye Khan, Kolla R L Anand Swarup, Edward J Johns. The contribution of α1B-adrenoceptor subtype in the renal vasculature of fructose-fed Sprague-Dawley rats. European journal of nutrition. 2011 Jun; 50(4):251-60. doi: 10.1007/s00394-010-0133-8. [PMID: 20882287]
  • Mohammed H Abdulla, Munavvar A Sattar, Nor A Abdullah, Abdul Hye Khan, Kolla R L Anand Swarup, Hassaan A Rathore, Raisa N Kazi, Fathihah Basri, Edward J Johns. Effect of renal sympathetic nerve on adrenergically and angiotensin II-induced renal vasoconstriction in normal Wistar-Kyoto rats. Upsala journal of medical sciences. 2011 Mar; 116(1):18-25. doi: 10.3109/03009734.2010.526723. [PMID: 21047287]
  • Ingemar Jacobson, Leif Carlsson, Göran Duker. Beat-by-beat QT interval variability, but not QT prolongation per se, predicts drug-induced torsades de pointes in the anaesthetised methoxamine-sensitized rabbit. Journal of pharmacological and toxicological methods. 2011 Jan; 63(1):40-6. doi: 10.1016/j.vascn.2010.04.010. [PMID: 20451633]
  • Yara Haddad, Diane Vallerand, Antoine Brault, Jean Spénard, Pierre S Haddad. NCX 1000 Alone or in Combination with Vitamin E Reverses Experimental Nonalcoholic Steatohepatitis in the Rat Similarly to UDCA. International journal of hepatology. 2011; 2011(?):136816. doi: 10.4061/2011/136816. [PMID: 22013536]
  • Davi A Pontes, Glaura S A Fernandes, Renata C Piffer, Daniela C C Gerardin, Oduvaldo C M Pereira, Wilma G Kempinas. Ejaculatory dysfunction in streptozotocin-induced diabetic rats: the role of testosterone. Pharmacological reports : PR. 2011; 63(1):130-8. doi: 10.1016/s1734-1140(11)70407-8. [PMID: 21441620]
  • I M Liu, J T Cheng. Mediation of Endogenous β-Endorphin in the Plasma Glucose-Lowering Action of Herbal Products Observed in Type 1-Like Diabetic Rats. Evidence-based complementary and alternative medicine : eCAM. 2011; 2011(?):987876. doi: 10.1093/ecam/nen078. [PMID: 19095661]
  • Jacek Sapa, Alicja Nowaczyk, Katarzyna Kulig. Antiarrhythmic and antioxidant activity of novel pyrrolidin-2-one derivatives with adrenolytic properties. Naunyn-Schmiedeberg's archives of pharmacology. 2011 Jan; 383(1):13-25. doi: 10.1007/s00210-010-0566-x. [PMID: 20949258]
  • Patcharin Tep-Areenan, Pattara Sawasdee, Michael Randall. Possible mechanisms of vasorelaxation for 5,7-dimethoxyflavone from Kaempferia parviflora in the rat aorta. Phytotherapy research : PTR. 2010 Oct; 24(10):1520-5. doi: 10.1002/ptr.3164. [PMID: 20878704]
  • Sherry LeCLere, Eric A Schmelz, Prem S Chourey. Sugar levels regulate tryptophan-dependent auxin biosynthesis in developing maize kernels. Plant physiology. 2010 May; 153(1):306-18. doi: 10.1104/pp.110.155226. [PMID: 20237017]
  • Lan Wang, Jing Ren, Meng Sun, Sicen Wang. A combined cell membrane chromatography and online HPLC/MS method for screening compounds from Radix Caulophylli acting on the human alpha(1A)-adrenoceptor. Journal of pharmaceutical and biomedical analysis. 2010 Apr; 51(5):1032-6. doi: 10.1016/j.jpba.2009.11.007. [PMID: 20004544]
  • Diana Tripovic, Svetlana Pianova, Elspeth M McLachlan, James A Brock. Transient supersensitivity to alpha-adrenoceptor agonists, and distinct hyper-reactivity to vasopressin and angiotensin II after denervation of rat tail artery. British journal of pharmacology. 2010 Jan; 159(1):142-53. doi: 10.1111/j.1476-5381.2009.00520.x. [PMID: 20002103]
  • G Fanciulli, P A Tomasi, A P Delitala, G Delitala. Activation of alpha1-adrenoceptors inhibits growth hormone secretion in humans. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 2009 Oct; 117(9):460-2. doi: 10.1055/s-0029-1202796. [PMID: 19373756]
  • M H Abdulla, M A Sattar, Md A H Khan, N A Abdullah, E J Johns. Influence of sympathetic and AT-receptor blockade on angiotensin II and adrenergic agonist-induced renal vasoconstrictions in spontaneously hypertensive rats. Acta physiologica (Oxford, England). 2009 Mar; 195(3):397-404. doi: 10.1111/j.1748-1716.2008.01895.x. [PMID: 19183357]
  • R N Kazi, A S Munavvar, N A Abdullah, A H Khan, E J Johns. Influence of high dietary sodium intake on the functional subtypes of alpha-adrenoceptors in the renal cortical vasculature of Wistar-Kyoto rats. Autonomic & autacoid pharmacology. 2009 Jan; 29(1-2):25-31. doi: 10.1111/j.1474-8673.2009.00428.x. [PMID: 19302553]
  • Md Abdul Hye Khan, Munavvar Abdul Sattar, Nor Azizan Abdullah, Mohammed H Abdulla, Ibrahim M Salman, Raisa N Kazi, K R L Anand Swarup, Hassaan A Rathore, Fathihah Basri, Nurjannah M Hussain, Aidiahmad Dewa, Edward James Johns. Functional subtypes of renal alpha1-adrenoceptor in spontaneously hypertensive rats with streptozotocin-induced experimental diabetic nephropathy. Kidney & blood pressure research. 2009; 32(5):349-59. doi: 10.1159/000249149. [PMID: 19844130]
  • Veronica Santos, Karin Jannet Vera López, Luciana Moraes Santos, Mauricio Yonamine, Maria José Carvalho Carmona, Silvia Regina Cavani Jorge Santos. Determining plasma morphine levels using GC-MS after solid phase extraction to monitor drug levels in the postoperative period. Clinics (Sao Paulo, Brazil). 2008 Jun; 63(3):307-14. doi: 10.1590/s1807-59322008000300004. [PMID: 18568238]
  • A Armenia, Munavvar Abdul Sattar, Nor Azizan Abdullah, Md Abdul Hye Khan, Edward James Johns. Functional subtypes of renal alpha1-adrenoceptor in diabetic and non-diabetic 2K1C Goldblatt renovascular hypertension. Acta pharmacologica Sinica. 2008 May; 29(5):564-72. doi: 10.1111/j.1745-7254.2008.00788.x. [PMID: 18430364]
  • M H Abdulla, M A Sattar, I M Salman, N A Abdullah, O Z Ameer, Md A H Khan, E J Johns. Effect of acute unilateral renal denervation on renal hemodynamics in spontaneously hypertensive rats. Autonomic & autacoid pharmacology. 2008 Apr; 28(2-3):87-94. doi: 10.1111/j.1474-8673.2008.00421.x. [PMID: 18598290]
  • M A Hye Khan, M A Sattar, N A Abdullah, E J Johns. Influence of combined hypertension and renal failure on functional alpha(1)-adrenoceptor subtypes in the rat kidney. British journal of pharmacology. 2008 Mar; 153(6):1232-41. doi: 10.1038/bjp.2008.13. [PMID: 18246093]
  • M A Sattar, N A Abdullah, Md A H Khan, E J Johns. Alpha1A- and alpha1D-adrenoceptors are the major functional subtypes of renal alpha1-adrenoceptors in streptozotocin-induced diabetic and normal Sprague-Dawley rats. Autonomic & autacoid pharmacology. 2008 Jan; 28(1):1-10. doi: 10.1111/j.1474-8673.2007.00412.x. [PMID: 18257746]
  • Frédéric Michel, Serge Simonet, Christine Vayssettes-Courchay, Florence Bertin, Patricia Sansilvestri-Morel, Fabienne Bernhardt, Jérôme Paysant, Jean-Sébastien Silvestre, Bernard I Levy, Michel Félétou, Tony J Verbeuren. Altered TP receptor function in isolated, perfused kidneys of nondiabetic and diabetic ApoE-deficient mice. American journal of physiology. Renal physiology. 2008 Jan; 294(1):F120-9. doi: 10.1152/ajprenal.00111.2007. [PMID: 17942572]
  • Md Abdul Hye Khan, Munavvar Abdul Sattar, Nor Azizan Abdullah, Edward James Johns. Cisplatin-induced nephrotoxicity causes altered renal hemodynamics in Wistar Kyoto and spontaneously hypertensive rats: role of augmented renal alpha-adrenergic responsiveness. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie. 2007 Nov; 59(3-4):253-60. doi: 10.1016/j.etp.2007.05.005. [PMID: 17764917]
  • Han Liu, Fang Feng, Ming Ma, Shuangjin Cui, Darong Xie, Sizhi Xu. Pharmacokinetic study of three cardiovascular drugs by high-performance liquid chromatography using pre-column derivatization with 9,10-anthraquinone-2-sulfonyl chloride. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2007 Oct; 858(1-2):42-8. doi: 10.1016/j.jchromb.2007.08.004. [PMID: 17766197]
  • P J Nisar, H-J Gruss, D Bush, A G Acheson, J H Scholefield. Intra-anal application of L-erythro methoxamine gel increases anal resting pressure in patients with incontinence. The British journal of surgery. 2007 Sep; 94(9):1155-61. doi: 10.1002/bjs.5821. [PMID: 17542041]
  • Abdul H Khan, Munavvar A Sattar, Nor A Abdullah, Edward J Johns. Influence of cisplatin-induced renal failure on the alpha(1)-adrenoceptor subtype causing vasoconstriction in the kidney of the rat. European journal of pharmacology. 2007 Aug; 569(1-2):110-8. doi: 10.1016/j.ejphar.2007.04.063. [PMID: 17559832]
  • Wim Laleman, Lien Van Landeghem, Ingrid Van der Elst, Marcel Zeegers, Johan Fevery, Frederik Nevens. Nitroflurbiprofen, a nitric oxide-releasing cyclooxygenase inhibitor, improves cirrhotic portal hypertension in rats. Gastroenterology. 2007 Feb; 132(2):709-19. doi: 10.1053/j.gastro.2006.12.041. [PMID: 17258737]
  • U Deniz Dincer, Alberto G Araiza, Jarrod D Knudson, Patricia E Molina, Johnathan D Tune. Sensitization of coronary alpha-adrenoceptor vasoconstriction in the prediabetic metabolic syndrome. Microcirculation (New York, N.Y. : 1994). 2006 Oct; 13(7):587-95. doi: 10.1080/10739680600885228. [PMID: 16990217]
  • Katsuo Kamata, Masao Hosokawa, Takayuki Matsumoto, Tsuneo Kobayashi. Altered arachidonic acid-mediated responses in the perfused kidney of the streptozotocin-induced diabetic rat. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi. 2006 Oct; 42(5):171-87. doi: 10.1540/jsmr.42.171. [PMID: 17159333]
  • Shingo Takatori, Yoshito Zamami, Mitsunobu Mio, Yuji Kurosaki, Hiromu Kawasaki. Chronic hyperinsulinemia enhances adrenergic vasoconstriction and decreases calcitonin gene-related peptide-containing nerve-mediated vasodilation in pithed rats. Hypertension research : official journal of the Japanese Society of Hypertension. 2006 May; 29(5):361-8. doi: 10.1291/hypres.29.361. [PMID: 16832157]
  • Martin Hennenberg, Erwin Biecker, Jonel Trebicka, Kerstin Jochem, Qi Zhou, Martina Schmidt, Karl H Jakobs, Tilman Sauerbruch, Jörg Heller. Defective RhoA/Rho-kinase signaling contributes to vascular hypocontractility and vasodilation in cirrhotic rats. Gastroenterology. 2006 Mar; 130(3):838-54. doi: 10.1053/j.gastro.2005.11.029. [PMID: 16530523]
  • P J Nisar, H-J Gruss, D Bush, N Barras, A G Acheson, J H Scholefield. Intra-anal and rectal application of L-erythro methoxamine gel increases anal resting pressure in healthy volunteers. The British journal of surgery. 2005 Dec; 92(12):1539-45. doi: 10.1002/bjs.5171. [PMID: 16231282]
  • Fabiana L Paganini Stein, Bruno Schmidt, Eliana Badiale Furlong, Leonor A Souza-Soares, Maria Cristina Flores Soares, Marta R Cezar Vaz, Ana L Muccillo Baisch. Vascular responses to extractable fractions of Ilex paraguariensis in rats fed standard and high-cholesterol diets. Biological research for nursing. 2005 Oct; 7(2):146-56. doi: 10.1177/1099800405280521. [PMID: 16267376]
  • Jörg Heller, Jonel Trebicka, Thomas Shiozawa, Michael Schepke, Markus Neef, Martin Hennenberg, Tilman Sauerbruch. Vascular, hemodynamic and renal effects of low-dose losartan in rats with secondary biliary cirrhosis. Liver international : official journal of the International Association for the Study of the Liver. 2005 Jun; 25(3):657-66. doi: 10.1111/j.1478-3231.2005.01053.x. [PMID: 15910503]
  • María García-Fernández, Inma Castilla-Cortázar, Matías Díaz-Sanchez, Iñigo Navarro, Juan Enrique Puche, Alberto Castilla, Amelia Díaz Casares, Encarna Clavijo, Salvador González-Barón. Antioxidant effects of insulin-like growth factor-I (IGF-I) in rats with advanced liver cirrhosis. BMC gastroenterology. 2005 Mar; 5(?):7. doi: 10.1186/1471-230x-5-7. [PMID: 15745444]
  • Dongzhe Song, Simon Hutchings, Catherine C Y Pang. Chronic N-acetylcysteine prevents fructose-induced insulin resistance and hypertension in rats. European journal of pharmacology. 2005 Jan; 508(1-3):205-10. doi: 10.1016/j.ejphar.2004.12.018. [PMID: 15680273]
  • Ana Luiza Muccillo Baisch, Humberto Urban, Alícia Navarro Ruiz. Endothelium-dependent vasorelaxing activity of aqueous extracts of lyophilized seeds of Casimiroa edulis (AECe) on rat mesenteric arterial bed. Journal of ethnopharmacology. 2004 Dec; 95(2-3):163-7. doi: 10.1016/j.jep.2004.06.018. [PMID: 15507330]
  • Dian Zhang, Bingxiang Yuan, Xiuling Deng, Guangde Yang, Langchong He, Youyi Zhang, Qide Han. Chromatography studies on bio-affinity of nine ligands of alpha1-adrenoceptor to alpha1D subtypes overexpressed in cell membrane. Science in China. Series C, Life sciences. 2004 Aug; 47(4):376-81. doi: 10.1360/03yc0109. [PMID: 15493479]
  • Sally G Hood, Robyn L Woods. Vagal reflex actions of atrial natriuretic peptide survive physiological but not pathological cardiac hypertrophy in rat. Experimental physiology. 2004 Jul; 89(4):445-54. doi: 10.1113/expphysiol.2004.027557. [PMID: 15131074]
  • A Armenia, A S Munavvar, N A Abdullah, A Helmi, E J Johns. The contribution of adrenoceptor subtype(s) in the renal vasculature of diabetic spontaneously hypertensive rats. British journal of pharmacology. 2004 Jun; 142(4):719-26. doi: 10.1038/sj.bjp.0705842. [PMID: 15172958]
  • Beatriz Civantos, Amaya Aleixandre. Blood pressure and alpha-vascular reactivity in hypertensive rats treated with amlodipine and dietary Ca. European journal of pharmacology. 2004 Apr; 489(1-2):101-10. doi: 10.1016/j.ejphar.2004.02.032. [PMID: 15063161]
  • Malika Israilova, Takashi Tanaka, Fumiko Suzuki, Shigeru Morishima, Ikunobu Muramatsu. Pharmacological characterization and cross talk of alpha1a- and alpha1b-adrenoceptors coexpressed in human embryonic kidney 293 cells. The Journal of pharmacology and experimental therapeutics. 2004 Apr; 309(1):259-66. doi: 10.1124/jpet.103.061796. [PMID: 14722320]
  • K Hori, S Saito. Microvascular mechanisms by which the combretastatin A-4 derivative AC7700 (AVE8062) induces tumour blood flow stasis. British journal of cancer. 2003 Oct; 89(7):1334-44. doi: 10.1038/sj.bjc.6601261. [PMID: 14520469]
  • Matthew R Farmer, Richard E Roberts, Sheila M Gardiner, Vera Ralevic. Effects of in vivo lipopolysaccharide infusion on vasoconstrictor function of rat isolated mesentery, kidney, and aorta. The Journal of pharmacology and experimental therapeutics. 2003 Aug; 306(2):538-45. doi: 10.1124/jpet.103.051805. [PMID: 12730359]
  • Rabelais Tatchum-Talom, Céline Martel, Fernand Labrie, André Marette. Acute vascular effects of the selective estrogen receptor modulator EM-652 (SCH 57068) in the rat mesenteric vascular bed. Cardiovascular research. 2003 Feb; 57(2):535-43. doi: 10.1016/s0008-6363(02)00666-1. [PMID: 12566126]
  • Roger G Pertwee, Ruth A Ross, Susan J Craib, Adèle Thomas. (-)-Cannabidiol antagonizes cannabinoid receptor agonists and noradrenaline in the mouse vas deferens. European journal of pharmacology. 2002 Dec; 456(1-3):99-106. doi: 10.1016/s0014-2999(02)02624-9. [PMID: 12450575]
  • Ayako Makino, Katsuo Kamata. Effects of chronic administration of L-arginine on vasoactive responses induced by endothelin-1 and its plasma level in streptozotocin-induced diabetic rats. Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi. 2002 Oct; 38(4-5):101-15. doi: 10.1540/jsmr.38.101. [PMID: 12596889]
  • Christine E Wright, James A Angus, Paul I Korner. Structural factors increase blood pressure through the interaction of resistance vessel geometry with neurohumoral and local factors: estimates in rabbits with renal cellophane-wrap hypertension with intact effectors and during neurohumoral blockade. Journal of hypertension. 2002 Mar; 20(3):471-83. doi: 10.1097/00004872-200203000-00023. [PMID: 11875315]
  • Hui Shen, Andrew S Greene, Elliot A Stein, Anthony G Hudetz. Functional cerebral hyperemia is unaffected by isovolemic hemodilution. Anesthesiology. 2002 Jan; 96(1):142-7. doi: 10.1097/00000542-200201000-00027. [PMID: 11753014]
  • D A Misurski, R L Hopfner, V Gopalakrishnan. Attenuated agonist evoked vasoconstrictor responses in the perfused mesenteric vascular bed of streptozotocin diabetic rats. Experimental biology and medicine (Maywood, N.J.). 2001 Nov; 226(10):940-6. doi: 10.1177/153537020122601010. [PMID: 11682701]
  • P Dutta, D E Ryan, R Tabrizchi. The influence of phosphodiesterase inhibitor, rolipram, on hemodynamics in lipopolysaccharide-treated rats. Japanese journal of pharmacology. 2001 Mar; 85(3):241-9. doi: 10.1254/jjp.85.241. [PMID: 11325016]
  • A Kiss, G Aguilera. Role of alpha-1-adrenergic receptors in the regulation of corticotropin-releasing hormone mRNA in the paraventricular nucleus of the hypothalamus during stress. Cellular and molecular neurobiology. 2000 Dec; 20(6):683-94. doi: 10.1023/a:1007098724683. [PMID: 11100976]
  • J Nakasone, M Higuchi, K Miyagi, T Matsuzaki, K Noguchi, M Sakanashi, S Yamashiro, T Itomine, M Sakanashi. Comparison of contractile responses relative to protein between isolated diabetic and non-diabetic rat aortae to KCl and alpha-adrenoceptor agonists in different extracellular calcium concentrations. Arzneimittel-Forschung. 2000 Dec; 50(12):1078-83. doi: 10.1055/s-0031-1300344. [PMID: 11190772]
  • K A Harrison, S S Davies, G K Marathe, T McIntyre, S Prescott, K M Reddy, J R Falck, R C Murphy. Analysis of oxidized glycerophosphocholine lipids using electrospray ionization mass spectrometry and microderivatization techniques. Journal of mass spectrometry : JMS. 2000 Feb; 35(2):224-36. doi: 10.1002/(sici)1096-9888(200002)35:2<224::aid-jms933>3.0.co;2-g. [PMID: 10679985]
  • R L Hopfner, D A Misurski, J R McNeill, V Gopalakrishnan. Effect of sodium orthovanadate treatment on cardiovascular function in the hyperinsulinemic, insulin-resistant obese Zucker rat. Journal of cardiovascular pharmacology. 1999 Dec; 34(6):811-7. doi: 10.1097/00005344-199912000-00007. [PMID: 10598124]
  • R Wiest, S Das, G Cadelina, G Garcia-Tsao, S Milstien, R J Groszmann. Bacterial translocation in cirrhotic rats stimulates eNOS-derived NO production and impairs mesenteric vascular contractility. The Journal of clinical investigation. 1999 Nov; 104(9):1223-33. doi: 10.1172/jci7458. [PMID: 10545521]
  • B Civantos, V López-Miranda, A Ortega, M A Aleixandre de Artiñano. Alpha-adrenoceptor-mediated pressor responses in pithed rats fed diets with different calcium contents. European journal of pharmacology. 1999 Oct; 382(2):91-101. doi: 10.1016/s0014-2999(99)00556-7. [PMID: 10528143]
  • F Gustafsson, N H Holstein-Rathlou. Angiotensin II modulates conducted vasoconstriction to norepinephrine and local electrical stimulation in rat mesenteric arterioles. Cardiovascular research. 1999 Oct; 44(1):176-84. doi: 10.1016/s0008-6363(99)00174-1. [PMID: 10615401]
  • D Zelena, D T Kiem, I Barna, G B Makara. Alpha 2-adrenoreceptor subtypes regulate ACTH and beta-endorphin secretions during stress in the rat. Psychoneuroendocrinology. 1999 Apr; 24(3):333-43. doi: 10.1016/s0306-4530(98)00081-x. [PMID: 10101737]
  • K Kamata, T Hayashi. Effects of chronic treatment with the spontaneous nitric oxide releaser FK409 on vascular responses in established streptozotocin-induced diabetic rat. Research communications in molecular pathology and pharmacology. 1999 Mar; 103(3):275-94. doi: NULL. [PMID: 10509739]
  • Z H Cui, H Arakawa, I Kawikova, B E Skoogh, J Lötvall. Relationship between systemic blood pressure, airway blood flow and plasma exudation in guinea-pig. Acta physiologica Scandinavica. 1999 Feb; 165(2):121-7. doi: 10.1046/j.1365-201x.1999.00491.x. [PMID: 10090322]
  • T Yoshinaga, S Zhang, T Niidome, M Hiraoka, Y Hirano. Potentiation of recombinant L-type Ca channel currents by alpha1-adrenoceptors coexpressed in baby hamster kidney (BHK) cells. Life sciences. 1999; 64(18):1643-51. doi: 10.1016/s0024-3205(99)00102-2. [PMID: 10328524]
  • I M Liu, C S Niu, T C Chi, D H Kuo, J T Cheng. Investigations of the mechanism of the reduction of plasma glucose by cold-stress in streptozotocin-induced diabetic rats. Neuroscience. 1999; 92(3):1137-42. doi: 10.1016/s0306-4522(99)00068-8. [PMID: 10426552]
  • R L Hopfner, D Misurski, T W Wilson, J R McNeill, V Gopalakrishnan. Insulin and vanadate restore decreased plasma endothelin concentrations and exaggerated vascular responses to normal in the streptozotocin diabetic rat. Diabetologia. 1998 Oct; 41(10):1233-40. doi: 10.1007/s001250051057. [PMID: 9794113]
  • R L Hopfner, J R McNeill, V Gopalakrishnan. Vanadate treatment normalizes exaggerated vascular smooth muscle responses in the obese Zucker rat. European journal of pharmacology. 1998 Sep; 357(1):61-5. doi: 10.1016/s0014-2999(98)00535-4. [PMID: 9788774]
  • D C Brodbelt, J Harris, P M Taylor. Pituitary-adrenocortical effects of methoxamine infusion on halothane anaesthetised ponies. Research in veterinary science. 1998 Sep; 65(2):119-23. doi: 10.1016/s0034-5288(98)90162-x. [PMID: 9839889]
  • A L Muccillo Baisch, K B Johnston, F L Paganini Stein. Endothelium-dependent vasorelaxing activity of aqueous extracts of Ilex paraguariensis on mesenteric arterial bed of rats. Journal of ethnopharmacology. 1998 Mar; 60(2):133-9. doi: 10.1016/s0378-8741(97)00140-2. [PMID: 9582003]
  • K E Scrogin, D C Hatton, Y Chi, F C Luft. Chronic nitric oxide inhibition with L-NAME: effects on autonomic control of the cardiovascular system. The American journal of physiology. 1998 02; 274(2):R367-74. doi: 10.1152/ajpregu.1998.274.2.r367. [PMID: 9486293]
  • D J Buggy, C K Power, R Meeke, S O'Callaghan, C Moran, G T O'Brien. Prevention of spinal anaesthesia-induced hypotension in the elderly: i.m. methoxamine or combined hetastarch and crystalloid. British journal of anaesthesia. 1998 Feb; 80(2):199-203. doi: 10.1093/bja/80.2.199. [PMID: 9602585]
  • T A Bruning, M J Kemme, P C Chang, Y Muizert, P A van Zwieten. Calculation of plasma concentrations of intra-arterially infused compounds in forearm plethysmography. Cardiovascular research. 1998 Jan; 37(1):210-5. doi: 10.1016/s0008-6363(97)00218-6. [PMID: 9539875]
  • K Matsumoto, S Kohno, K Ojima, Y Tezuka, S Kadota, H Watanabe. Effects of methylenechloride-soluble fraction of Japanese angelica root extract, ligustilide and butylidenephthalide, on pentobarbital sleep in group-housed and socially isolated mice. Life sciences. 1998; 62(23):2073-82. doi: 10.1016/s0024-3205(98)00182-9. [PMID: 9627086]
  • C Krüger, A Kalenka, A Haunstetter, M Schweizer, C Maier, U Rühle, H Ehmke, W Kübler, M Haass. Baroreflex sensitivity and heart rate variability in conscious rats with myocardial infarction. The American journal of physiology. 1997 11; 273(5):H2240-7. doi: 10.1152/ajpheart.1997.273.5.h2240. [PMID: 9374759]
  • R J Windle, M M Brady, T Kunanandam, A P Da Costa, B C Wilson, M Harbuz, S L Lightman, C D Ingram. Reduced response of the hypothalamo-pituitary-adrenal axis to alpha1-agonist stimulation during lactation. Endocrinology. 1997 Sep; 138(9):3741-8. doi: 10.1210/endo.138.9.5405. [PMID: 9275060]
  • K Kamata, M Hosokawa. Endothelial dysfunction in the perfused kidney from the streptozotocin-induced diabetic rat. Research communications in molecular pathology and pharmacology. 1997 Apr; 96(1):57-70. doi: NULL. [PMID: 9178368]
  • K Matsumoto, S Kohno, Y Tezuka, S Kadota, H Watanabe. Effect of Japanese angelica root extract on pentobarbital-induced sleep in group-housed and socially isolated mice: evidence for the central action. Japanese journal of pharmacology. 1997 Apr; 73(4):353-6. doi: 10.1254/jjp.73.353. [PMID: 9165373]
  • L Xu, V L Brooks. ANG II chronically supports renal and lumbar sympathetic activity in sodium-deprived, conscious rats. The American journal of physiology. 1996 Dec; 271(6 Pt 2):H2591-8. doi: 10.1152/ajpheart.1996.271.6.h2591. [PMID: 8997320]
  • J García-Estañ, N M Atucha, R J Groszmann. Renal response to methoxamine in portal hypertensive rats: role of prostaglandins and nitric oxide. Journal of hepatology. 1996 Aug; 25(2):206-11. doi: 10.1016/s0168-8278(96)80075-4. [PMID: 8878783]
  • G F DiBona, S Y Jones, L L Sawin. Effect of endogenous angiotensin II on renal nerve activity and its arterial baroreflex regulation. The American journal of physiology. 1996 Aug; 271(2 Pt 2):R361-7. doi: 10.1152/ajpregu.1996.271.2.r361. [PMID: 8770135]