2-hydroxyestrone (BioDeep_00000405247)

Main id: BioDeep_00000637483

 

natural product


代谢物信息卡片


2-hydroxyestrone

化学式: C18H22O3 (286.1569)
中文名称: 2-羟基雌酮
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: CC12CCC3C(C1CCC2=O)CCC4=CC(=C(C=C34)O)O
InChI: InChI=1S/C18H22O3/c1-18-7-6-11-12(14(18)4-5-17(18)21)3-2-10-8-15(19)16(20)9-13(10)11/h8-9,11-12,14,19-20H,2-7H2,1H3/t11-,12+,14-,18-/m0/s1

描述信息

C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C483 - Therapeutic Estrogen
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones
A 2-hydroxy steroid that is estrone substituted by a hydroxy group at position 2.
D020011 - Protective Agents > D016588 - Anticarcinogenic Agents
D000970 - Antineoplastic Agents

同义名列表

2 个代谢物同义名

2-hydroxyestrone; 2-Hydroxyestrone



数据库引用编号

16 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

9 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 7 BGLAP, CASP3, CYP1A1, CYP3A4, ESR1, PGR, PRL
Peripheral membrane protein 3 CYP1A1, CYP1B1, ESR1
Endoplasmic reticulum membrane 6 CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, CYP3A5
Nucleus 7 CASP3, ESR1, ESR2, IGFBP3, KLK3, PGR, PRL
cytosol 4 CASP3, COMT, ESR1, PGR
dendrite 2 BGLAP, COMT
nucleoplasm 5 CASP3, ESR1, ESR2, PGR, PRL
RNA polymerase II transcription regulator complex 1 PRL
Cell membrane 2 COMT, ESR1
Cytoplasmic side 1 ESR1
Multi-pass membrane protein 1 CYP19A1
Synapse 1 COMT
glutamatergic synapse 1 CASP3
Golgi apparatus 1 ESR1
Golgi membrane 1 INS
mitochondrial inner membrane 1 CYP1A1
neuronal cell body 1 CASP3
plasma membrane 4 COMT, ESR1, KLK3, PGR
Membrane 6 COMT, CYP19A1, CYP1B1, CYP3A4, CYP3A5, ESR1
axon 1 COMT
extracellular exosome 3 COMT, KLK3, SHBG
endoplasmic reticulum 1 CYP19A1
extracellular space 7 BGLAP, CRP, GNRH1, IGFBP3, INS, KLK3, PRL
mitochondrion 4 BCO2, CYP1A1, CYP1B1, ESR2
protein-containing complex 2 ESR1, KLK3
intracellular membrane-bounded organelle 7 COMT, CYP1A1, CYP1A2, CYP1B1, CYP3A4, CYP3A5, ESR2
Microsome membrane 6 CYP19A1, CYP1A1, CYP1A2, CYP1B1, CYP3A4, CYP3A5
postsynaptic density 1 CASP3
Secreted 6 BGLAP, CRP, IGFBP3, INS, PRL, SHBG
extracellular region 8 BGLAP, CRP, GNRH1, IGFBP3, INS, KLK3, PRL, SHBG
mitochondrial outer membrane 1 PGR
mitochondrial matrix 1 BCO2
Extracellular side 1 COMT
transcription regulator complex 1 ESR1
perikaryon 1 BGLAP
Single-pass type II membrane protein 1 COMT
vesicle 1 BGLAP
Mitochondrion inner membrane 1 CYP1A1
secretory granule 1 KLK3
chromatin 4 ESR1, ESR2, PGR, PRL
endosome lumen 2 INS, PRL
euchromatin 1 ESR1
secretory granule lumen 1 INS
Golgi lumen 2 BGLAP, INS
endoplasmic reticulum lumen 3 BGLAP, IGFBP3, INS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
[Isoform 1]: Nucleus 1 ESR1
death-inducing signaling complex 1 CASP3
insulin-like growth factor binding protein complex 1 IGFBP3
insulin-like growth factor ternary complex 1 IGFBP3
[Isoform 4]: Mitochondrion outer membrane 1 PGR
[Isoform Soluble]: Cytoplasm 1 COMT
[Isoform Membrane-bound]: Cell membrane 1 COMT


文献列表

  • Xiaoli Zhang, Na Yang, Min Wang, JiaJia Ge, Huaijun Zhu, Jun He, Weihong Ge. Establishment and validation of a sensitive LC-MS/MS method for quantification of urinary estrogens in women with gestational diabetes mellitus. Journal of pharmaceutical and biomedical analysis. 2022 Nov; 221(?):115044. doi: 10.1016/j.jpba.2022.115044. [PMID: 36126614]
  • Nhung Le, Melissa Cregger, Veronica Brown, Julio Loret de Mola, Pamela Bremer, Lyn Nguyen, Kathleen Groesch, Teresa Wilson, Paula Diaz-Sylvester, Andrea Braundmeier-Fleming. Association of microbial dynamics with urinary estrogens and estrogen metabolites in patients with endometriosis. PloS one. 2021; 16(12):e0261362. doi: 10.1371/journal.pone.0261362. [PMID: 34914785]
  • Frank Z Stanczyk. The 2-/16α-Hydroxylated Estrogen Ratio-Breast Cancer Risk Hypothesis: Insufficient Evidence for its Support. The Journal of steroid biochemistry and molecular biology. 2020 07; 201(?):105685. doi: 10.1016/j.jsbmb.2020.105685. [PMID: 32320758]
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  • Cynthia A Thomson, H H Sherry Chow, Betsy C Wertheim, Denise J Roe, Alison Stopeck, Gertraud Maskarinec, Maria Altbach, Pavani Chalasani, Chuan Huang, Meghan B Strom, Jean-Philippe Galons, Patricia A Thompson. A randomized, placebo-controlled trial of diindolylmethane for breast cancer biomarker modulation in patients taking tamoxifen. Breast cancer research and treatment. 2017 Aug; 165(1):97-107. doi: 10.1007/s10549-017-4292-7. [PMID: 28560655]
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  • Regina G Ziegler, Barbara J Fuhrman, Steven C Moore, Charles E Matthews. Epidemiologic studies of estrogen metabolism and breast cancer. Steroids. 2015 Jul; 99(Pt A):67-75. doi: 10.1016/j.steroids.2015.02.015. [PMID: 25725255]
  • Dina Nikitina, Marcia Llacuachaqui, Daniel Sepkovic, H Leon Bradlow, Steven A Narod, Joanne Kotsopoulos. The effect of oral 3,3'-diindolylmethane supplementation on the 2:16α-OHE ratio in BRCA1 mutation carriers. Familial cancer. 2015 Jun; 14(2):281-6. doi: 10.1007/s10689-015-9783-2. [PMID: 25613194]
  • Anushka Dikshit, Manoel Adrião Gomes Filho, Erfan Eilati, Stacey McGee, Carrie Small, Chunqi Gao, Thomas Klug, Dale Buchanan Hales. Flaxseed reduces the pro-carcinogenic micro-environment in the ovaries of normal hens by altering the PG and oestrogen pathways in a dose-dependent manner. The British journal of nutrition. 2015 May; 113(9):1384-95. doi: 10.1017/s000711451500029x. [PMID: 25850566]
  • Xiangyan Ruan, Harald Seeger, Diethelm Wallwiener, Jens Huober, Alfred O Mueck. The ratio of the estradiol metabolites 2-hydroxyestrone (2-OHE1) and 16α-hydroxyestrone (16-OHE1) may predict breast cancer risk in postmenopausal but not in premenopausal women: two case-control studies. Archives of gynecology and obstetrics. 2015 May; 291(5):1141-6. doi: 10.1007/s00404-014-3512-1. [PMID: 25318606]
  • Paulina M Merino, Daniela Martínez, German Iñiguez, Patricia Lopez, Fernando Cassorla, Francisco Perez-Bravo, Ethel Codner. Elevation of C-reactive protein during the luteal phase in healthy adolescents. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2015 Apr; 31(4):260-3. doi: 10.3109/09513590.2014.982086. [PMID: 25392126]
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  • Gertraud Maskarinec, Sreang Heak, Yukiko Morimoto, Laurie Custer, Adrian A Franke. The relation of urinary estrogen metabolites with mammographic densities in premenopausal women. Cancer epidemiology. 2012 Oct; 36(5):e310-6. doi: 10.1016/j.canep.2012.03.014. [PMID: 22537763]
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  • Nadia Obi, Alina Vrieling, Judith Heinz, Jenny Chang-Claude. Estrogen metabolite ratio: Is the 2-hydroxyestrone to 16α-hydroxyestrone ratio predictive for breast cancer?. International journal of women's health. 2011 Feb; 3(?):37-51. doi: 10.2147/ijwh.s7595. [PMID: 21339936]
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  • Jessica M Faupel-Badger, Barbara J Fuhrman, Xia Xu, Roni T Falk, Larry K Keefer, Timothy D Veenstra, Robert N Hoover, Regina G Ziegler. Comparison of liquid chromatography-tandem mass spectrometry, RIA, and ELISA methods for measurement of urinary estrogens. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2010 Jan; 19(1):292-300. doi: 10.1158/1055-9965.epi-09-0643. [PMID: 20056650]
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  • Annie Im, Victor G Vogel, Gretchen Ahrendt, Stacy Lloyd, Camille Ragin, Seymour Garte, Emanuela Taioli. Urinary estrogen metabolites in women at high risk for breast cancer. Carcinogenesis. 2009 Sep; 30(9):1532-5. doi: 10.1093/carcin/bgp139. [PMID: 19502596]
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  • MaryFran Sowers, Daniel McConnell, Mary L Jannausch, John F Randolph, Robert Brook, Ellen B Gold, Sybil Crawford, Bill Lasley. Oestrogen metabolites in relation to isoprostanes as a measure of oxidative stress. Clinical endocrinology. 2008 May; 68(5):806-13. doi: 10.1111/j.1365-2265.2007.03108.x. [PMID: 17980014]
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