medroxyprogesterone (BioDeep_00000402585)
Main id: BioDeep_00000409800
Volatile Flavor Compounds
代谢物信息卡片
medroxyprogesterone
化学式: C22H32O3 (344.23513219999995)
中文名称: 甲羟孕酮, 甲孕酮
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CC1CC2C(CCC3(C2CCC3(C(=O)C)O)C)C4(C1=CC(=O)CC4)C
InChI: InChI=1S/C22H32O3/c1-13-11-16-17(20(3)8-5-15(24)12-19(13)20)6-9-21(4)18(16)7-10-22(21,25)14(2)23/h12-13,16-18,25H,5-11H2,1-4H3
描述信息
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03A - Hormonal contraceptives for systemic use > G03AC - Progestogens
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03D - Progestogens > G03DA - Pregnen (4) derivatives
L - Antineoplastic and immunomodulating agents > L02 - Endocrine therapy > L02A - Hormones and related agents > L02AB - Progestogens
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents
CONFIDENCE standard compound; INTERNAL_ID 8739
同义名列表
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:6715
- KEGG: C07119
- KEGG: C75441
- KEGGdrug: D08166
- PubChem: 10631
- ChEMBL: CHEMBL1390
- MeSH: Medroxyprogesterone
- CAS: 520-85-4
- MoNA: FiehnHILIC002077
- MoNA: FiehnHILIC000505
- MoNA: HMDB0001939_ms_ms_1893
- MoNA: HMDB0001939_ms_ms_1894
- MoNA: HMDB0001939_ms_ms_1895
- MoNA: SM873901
- PubChem: 9330
- LipidMAPS: LMST02030176
- NIKKAJI: J6.606K
- RefMet: Medroxyprogesterone
- KNApSAcK: 6715
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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Scientific reports.
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Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Marta Jerez-Peña, Borja Salvador-Culla, María F de la Paz, Rafael I Barraquer. Bilateral Boston keratoprosthesis type 1 in a case of severe Mooren's ulcer.
European journal of ophthalmology.
2021 Mar; 31(2):NP33-NP38. doi:
10.1177/1120672120909768. [PMID: 32141311] - Margaret A Zimmerman, Benard O Ogola, Mary M Wilkinson, Bruna Visniauskas, Carmen De Miguel, Jill M Daniel, Sarah H Lindsey. Medroxyprogesterone opposes estradiol-induced renal damage in midlife ovariectomized Long Evans rats.
Menopause (New York, N.Y.).
2020 12; 27(12):1411-1419. doi:
10.1097/gme.0000000000001675. [PMID: 33109993] - Kenneth Omollo, Julie Lajoie, Julius Oyugi, Jocelyn M Wessels, Dufton Mwaengo, Joshua Kimani, Charu Kaushic, Keith R Fowke. Differential Elevation of Inflammation and CD4+ T Cell Activation in Kenyan Female Sex Workers and Non-Sex Workers Using Depot-Medroxyprogesterone Acetate.
Frontiers in immunology.
2020; 11(?):598307. doi:
10.3389/fimmu.2020.598307. [PMID: 33717049] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
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The Cochrane database of systematic reviews.
2019 04; 4(?):CD013315. doi:
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Journal of postgraduate medicine.
2019 Jan; 65(1):58-59. doi:
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Water research.
2018 06; 137(?):64-71. doi:
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Boletin medico del Hospital Infantil de Mexico.
2018; 75(5):295-302. doi:
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The Journal of clinical endocrinology and metabolism.
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2017 06; 7(1):2649. doi:
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Talanta.
2016 Nov; 160(?):592-599. doi:
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2016 Aug; 17(9):. doi:
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Theriogenology.
2016 Jul; 86(2):612-8. doi:
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Pakistan journal of pharmaceutical sciences.
2016 Jul; 29(4 Suppl):1379-82. doi:
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Fertility and sterility.
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The journal of obstetrics and gynaecology research.
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2012 Mar; 158(2):240-9. doi:
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Asian journal of sports medicine.
2012 Mar; 3(1):53-8. doi:
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Evidence-based complementary and alternative medicine : eCAM.
2012; 2012(?):579321. doi:
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Lipids in health and disease.
2011 Nov; 10(?):197. doi:
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Menopause (New York, N.Y.).
2011 Oct; 18(10):1101-12. doi:
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2011 Jul; 54(13):4548-58. doi:
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Journal of natural science, biology, and medicine.
2011 Jul; 2(2):154-63. doi:
10.4103/0976-9668.92322. [PMID: 22346228] - Maple M Fung, Sameer Poddar, Ricki Bettencourt, Simerjot Kaur Jassal, Elizabeth Barrett-Connor. A cross-sectional and 10-year prospective study of postmenopausal estrogen therapy and blood pressure, renal function, and albuminuria: the Rancho Bernardo Study.
Menopause (New York, N.Y.).
2011 Jun; 18(6):629-37. doi:
10.1097/gme.0b013e3181fca9c4. [PMID: 21326121] - Toshio Hayashi, Koichiro Ina, Morihiko Maeda, Hideki Nomura. The effects of selective estrogen receptor modulator treatment following hormone replacement therapy on elderly postmenopausal women with osteoporosis.
Nitric oxide : biology and chemistry.
2011 May; 24(4):199-203. doi:
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Ginekologia polska.
2011 Apr; 82(4):254-8. doi:
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The Korean journal of laboratory medicine.
2011 Apr; 31(2):95-7. doi:
10.3343/kjlm.2011.31.2.95. [PMID: 21474983] - Nicholas A Tritos, Thomas N Byrne, Chin-Lee Wu, Anne Klibanski. A patient with diabetes insipidus, anterior hypopituitarism and pituitary stalk thickening.
Nature reviews. Endocrinology.
2011 Jan; 7(1):54-9. doi:
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The open cardiovascular medicine journal.
2011; 5(?):35-40. doi:
10.2174/1874192401105010035. [PMID: 21660223] - Whitney Wharton, Laura D Baker, Carey E Gleason, Maritza Dowling, Jodi H Barnet, Sterling Johnson, Cynthia Carlsson, Suzanne Craft, Sanjay Asthana. Short-term hormone therapy with transdermal estradiol improves cognition for postmenopausal women with Alzheimer's disease: results of a randomized controlled trial.
Journal of Alzheimer's disease : JAD.
2011; 26(3):495-505. doi:
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Neuro endocrinology letters.
2011; 32(3):340-4. doi:
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PloS one.
2011; 6(11):e27141. doi:
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Molecular vision.
2011; 17(?):1918-28. doi:
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Evidence-based complementary and alternative medicine : eCAM.
2011; 2011(?):713274. doi:
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2010 Jul; 6(1):15. doi:
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British journal of cancer.
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Lancet (London, England).
2010 Feb; 375(9715):641-8. doi:
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Acta veterinaria Scandinavica.
2010 Feb; 52(?):13. doi:
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2010; 11(3):e141-9. doi:
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2010 Jan; 1(1):14-8. doi:
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2010; 13(2):162-74. doi:
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2009 Oct; 94(10):3798-805. doi:
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Evidence-based complementary and alternative medicine : eCAM.
2009 Mar; 6(1):99-105. doi:
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Archives of internal medicine.
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Zhonghua fu chan ke za zhi.
2008 Nov; 43(11):843-8. doi:
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Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology.
2008 Jul; 17(7):1674-81. doi:
10.1158/1055-9965.epi-07-2779. [PMID: 18628419] - Carlos Hermenegildo, Pilar J Oviedo, Andrés Laguna, Miguel Angel García-Pérez, Juan J Tarín, Antonio Cano. Transdermal estradiol reduces F2alpha-isoprostane levels in postmenopausal women.
Menopause (New York, N.Y.).
2008 Jul; 15(4 Pt 1):714-7. doi:
10.1097/gme.0b013e31815f8943. [PMID: 18340278] - David Hubacher, Elizabeth R Raymond, Mags Beksinska, Sinead Delany-Moretlwe, Jenni Smit, Tina Hylton-Kong, Thomas R Moench. Hormonal contraception and the risks of STI acquisition: results of a feasibility study to plan a future randomized trial.
Contraception.
2008 May; 77(5):366-70. doi:
10.1016/j.contraception.2008.01.006. [PMID: 18402854] - Janet Wittes. Times to event: why are they hard to visualize?.
Journal of the National Cancer Institute.
2008 Jan; 100(2):80-1. doi:
10.1093/jnci/djm304. [PMID: 18182615] - Patrick Royston, Mahesh K B Parmar, Douglas G Altman. Visualizing length of survival in time-to-event studies: a complement to Kaplan-Meier plots.
Journal of the National Cancer Institute.
2008 Jan; 100(2):92-7. doi:
10.1093/jnci/djm265. [PMID: 18182621] - Bernhard J Steinhoff. Pregnancy, epilepsy, and anticonvulsants.
Dialogues in clinical neuroscience.
2008; 10(1):63-75. doi:
NULL. [PMID: 18472485] - Sylvie Negrier, David Perol, Alain Ravaud, Christine Chevreau, Jacques-Olivier Bay, Remy Delva, Emmanuel Sevin, Armelle Caty, Bernard Escudier. Medroxyprogesterone, interferon alfa-2a, interleukin 2, or combination of both cytokines in patients with metastatic renal carcinoma of intermediate prognosis: results of a randomized controlled trial.
Cancer.
2007 Dec; 110(11):2468-77. doi:
10.1002/cncr.23056. [PMID: 17932908] - Peer Briken, Martin P Kafka. Pharmacological treatments for paraphilic patients and sexual offenders.
Current opinion in psychiatry.
2007 Nov; 20(6):609-13. doi:
10.1097/yco.0b013e3282f0eb0b. [PMID: 17921764] - Anny H Xiang, Miwa Kawakubo, Thomas A Buchanan, Siri L Kjos. A longitudinal study of lipids and blood pressure in relation to method of contraception in Latino women with prior gestational diabetes mellitus.
Diabetes care.
2007 Aug; 30(8):1952-8. doi:
10.2337/dc07-0180. [PMID: 17519432] - M K Ausmanas, C F Holinka, Y S Ling, C Christiansen. Effect of three doses of conjugated estrogens/medroxyprogesterone acetate on biomarkers of bone turnover and cartilage degradation in postmenopausal women: The Pan-Asia Menopause (PAM) study.
Climacteric : the journal of the International Menopause Society.
2007 Aug; 10(4):306-13. doi:
10.1080/13697130701463594. [PMID: 17653957] - Adriane Fugh-Berman, Jenna Bythrow. Bioidentical hormones for menopausal hormone therapy: variation on a theme.
Journal of general internal medicine.
2007 Jul; 22(7):1030-4. doi:
10.1007/s11606-007-0141-4. [PMID: 17549577] - Susan M Graham, Jared M Baeten, Barbra A Richardson, Daniel D Bankson, Ludo Lavreys, Jeckoniah O Ndinya-Achola, Kishorchandra Mandaliya, Julie Overbaugh, R Scott McClelland. Higher pre-infection vitamin E levels are associated with higher mortality in HIV-1-infected Kenyan women: a prospective study.
BMC infectious diseases.
2007 Jun; 7(?):63. doi:
10.1186/1471-2334-7-63. [PMID: 17594484] - Gale Harding, David Cella, Don Robinson, Parthiv J Mahadevia, Jason Clark, Dennis A Revicki. Symptom burden among patients with renal cell carcinoma (RCC): content for a symptom index.
Health and quality of life outcomes.
2007 Jun; 5(?):34. doi:
10.1186/1477-7525-5-34. [PMID: 17570854] - Shabana Saeed, Samina Bano. Inhibition of tryptophan pyrrolase activity in restraint female rats following medroxyprogesterone administration.
Journal of the College of Physicians and Surgeons--Pakistan : JCPSP.
2007 Feb; 17(2):63-8. doi:
02.2007/jcpsp.6368. [PMID: 17288848] - Tomasz Milewicz, Anna Kostecka, Iwona Rogatko, Krystyna Sztefko, Ewa Kwiatkowska-Panek, Stanisław Radowick, Józef Krzysiek. [Plasma levels of total cholesterol, LDL-cholesterol, and HDL-cholesterol in postmenopausal women during 12 months' oral administration of dydrogesterone or medroxyprogesterone combined with continuous transdermal supplementation of 17beta-estradiol].
Przeglad lekarski.
2007; 64(2):65-9. doi:
. [PMID: 17892034] - Jun Zhou, Zheng-yu Qin, Wei-li Li, Cui-ping Zhang, Li-ying Tian, Yi-juan Zhang, Ling Hu. [Clinical observation on therapeutic effect of electroacupuncture at Sanyinjiao (SP 6) on peri-menopausal syndrome].
Zhongguo zhen jiu = Chinese acupuncture & moxibustion.
2006 Sep; 26(9):617-20. doi:
". [PMID: 17036476] - L S Lim, P Shen, Y H Gong, L S Lee, E L Yong. Dynamics of progestogenic activity in serum following administration of Ligusticum chuanxiong.
Life sciences.
2006 Aug; 79(13):1274-80. doi:
10.1016/j.lfs.2006.03.039. [PMID: 16650443] - N L Smith, S R Heckbert, C J Doggen, R N Lemaitre, A P Reiner, T Lumley, J C M Meijers, B M Psaty, F R Rosendaal. The differential association of conjugated equine estrogen and esterified estrogen with activated protein C resistance in postmenopausal women.
Journal of thrombosis and haemostasis : JTH.
2006 Aug; 4(8):1701-6. doi:
10.1111/j.1538-7836.2006.02045.x. [PMID: 16879211] - Li-Nien Tseng, Wayne Huey-Herng Sheu, Esther Shih-Chu Ho, Howard Haw-Chang Lan, Chung-Chieh Hu, Chia-Hung Kao. Effects of alendronate combined with hormone replacement therapy on osteoporotic postmenopausal Chinese women.
Metabolism: clinical and experimental.
2006 Jun; 55(6):741-7. doi:
10.1016/j.metabol.2006.01.008. [PMID: 16713432] - Grazyna Bednarek-Tupikowska, Urszula Tworowska, Iwona Jedrychowska, Barbara Radomska, Krzysztof Tupikowski, Bozena Bidzinska-Speichert, Andrzej Milewicz. Effects of oestradiol and oestroprogestin on erythrocyte antioxidative enzyme system activity in postmenopausal women.
Clinical endocrinology.
2006 Apr; 64(4):463-8. doi:
10.1111/j.1365-2265.2006.02494.x. [PMID: 16584521] - See Kwok, Valentine Charlton-Menys, Philip Pemberton, Patrick McElduff, Paul N Durrington. Effects of dydrogesterone and norethisterone, in combination with oestradiol, on lipoproteins and inflammatory markers in postmenopausal women.
Maturitas.
2006 Mar; 53(4):439-46. doi:
10.1016/j.maturitas.2005.07.006. [PMID: 16139447] - Liqin Zhao, Roberta Diaz Brinton. Select estrogens within the complex formulation of conjugated equine estrogens (Premarin) are protective against neurodegenerative insults: implications for a composition of estrogen therapy to promote neuronal function and prevent Alzheimer's disease.
BMC neuroscience.
2006 Mar; 7(?):24. doi:
10.1186/1471-2202-7-24. [PMID: 16533397] - Chooi P Lee, Poulam M Patel, Peter J Selby, Barry W Hancock, Ian Mak, Lynda Pyle, Maggie G James, Debbie A Beirne, Sarah Steeds, Roger A'Hern, Martin E Gore, Tim Eisen. Randomized phase II study comparing thalidomide with medroxyprogesterone acetate in patients with metastatic renal cell carcinoma.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
2006 Feb; 24(6):898-903. doi:
10.1200/jco.2005.03.7309. [PMID: 16484699] - Urszula Stopińska-Głuszak, Jacek Waligóra, Tomasz Grzela, Michał Głuszak, Jarosław Jóźwiak, Dariusz Radomski, Piotr I Roszkowski, Jacek Malejczyk. Effect of estrogen/progesterone hormone replacement therapy on natural killer cell cytotoxicity and immunoregulatory cytokine release by peripheral blood mononuclear cells of postmenopausal women.
Journal of reproductive immunology.
2006 Feb; 69(1):65-75. doi:
10.1016/j.jri.2005.07.006. [PMID: 16236362] - Sang Wan Kim, Do Joon Park, Kyong Soo Park, Seong Yeon Kim, Bo Youn Cho, Hong Kyu Lee, Chan Soo Shin. Early changes in biochemical markers of bone turnover predict bone mineral density response to antiresorptive therapy in Korean postmenopausal women with osteoporosis.
Endocrine journal.
2005 Dec; 52(6):667-74. doi:
10.1507/endocrj.52.667. [PMID: 16410657] - Susan G Lakoski, Bridget Brosnihan, David M Herrington. Hormone therapy, C-reactive protein, and progression of atherosclerosis: data from the Estrogen Replacement on Progression of Coronary Artery Atherosclerosis (ERA) trial.
American heart journal.
2005 Nov; 150(5):907-11. doi:
10.1016/j.ahj.2004.11.025. [PMID: 16290959] - Sebastián Carranza Lira, Ana Luz MacGregor Gooch, Aleida Olivares, Sandra Luz González Legorreta, Nadia Saldívar, Juan Carlos Martínez Chéquer. [Modification of C3 and C4 levels after the administration of conjugated estrogens plus medroxiprogesterone or raloxifene in postmenopausal women].
Ginecologia y obstetricia de Mexico.
2005 Oct; 73(10):521-4. doi:
NULL. [PMID: 16583831] - Mehmet A Osmanağaoğlu, Selen Osmanağaoğlu, Tayfun Osmanağaoğlu, Bakiye Okumuş, Hasan Bozkaya. Effect of different preparations of hormone therapy on lipid and glucose metabolism, coagulation factors, and bone mineral density in overweight and obese postmenopausal women.
Fertility and sterility.
2005 Aug; 84(2):384-93. doi:
10.1016/j.fertnstert.2005.01.131. [PMID: 16084879] - Bradley D Anawalt, John K Amory, Karen L Herbst, Andrea D Coviello, Stephanie T Page, William J Bremner, Alvin M Matsumoto. Intramuscular testosterone enanthate plus very low dosage oral levonorgestrel suppresses spermatogenesis without causing weight gain in normal young men: a randomized clinical trial.
Journal of andrology.
2005 May; 26(3):405-13. doi:
10.2164/jandrol.04135. [PMID: 15867009] - S Palmer, D O McGregor, G F M Strippoli. Interventions for preventing bone disease in kidney transplant recipients.
The Cochrane database of systematic reviews.
2005 Apr; ?(2):CD005015. doi:
10.1002/14651858.cd005015.pub2. [PMID: 15846740] - Antonello Silvestri, Marco Gambacciani, Cristiana Vitale, Patrizia Monteleone, Massimo Ciaponi, Massimo Fini, Andrea R Genazzani, Giuseppe Mercuro, Giuseppe M C Rosano. Different effect of hormone replacement therapy, DHEAS and tibolone on endothelial function in postmenopausal women with increased cardiovascular risk.
Maturitas.
2005 Apr; 50(4):305-11. doi:
10.1016/j.maturitas.2004.07.012. [PMID: 15780531] - Fulvia Mancini, Nicola Persico, Alessandro D Genazzani, Annibale Volpe, Cesare Battaglia, Domenico De Aloysio. Effects of hormone replacement therapy on plasma viscosity and Doppler variations in postmenopausal non-smokers and heavy smokers.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.
2005 Apr; 20(4):221-6. doi:
10.1080/09513590400027281. [PMID: 16019365] - Eftihia Sbarouni, Zenon S Kyriakides, Dimitrios Th Kremastinos. The effect of hormone replacement therapy and simvastatin on plasma homocysteine.
Journal of women's health (2002).
2005 Mar; 14(2):154-8. doi:
10.1089/jwh.2005.14.154. [PMID: 15775733] - Sobiecka Małgorzata, Korzeniewska-Koseła Maria, Kuś Jan. [Pulmonary disease in patients with tuberous sclerosis].
Pneumonologia i alergologia polska.
2005; 73(1):48-56. doi:
. [PMID: 16539184] - Maha F M Soliman, Mohamed M Ibrahim. Antischistosomal action of atorvastatin alone and concurrently with medroxyprogesterone acetate on Schistosoma haematobium harboured in hamster: surface ultrastructure and parasitological study.
Acta tropica.
2005 Jan; 93(1):1-9. doi:
10.1016/j.actatropica.2004.08.006. [PMID: 15589792] - Hiroyuki Sumino, Shuichi Ichikawa, Yoshie Sawada, Hironosuke Sakamoto, Hisao Kumakura, Yoshiaki Takayama, Tetsuo Sakamaki, Masahiko Kurabayashi. Effects of hormone replacement therapy on blood coagulation and fibrinolysis in hypertensive and normotensive postmenopausal women.
Thrombosis research.
2005; 115(5):359-66. doi:
10.1016/j.thromres.2004.08.017. [PMID: 15733968] - Michio Otsuki, Kayoko Goya, Soji Kasayama. Vascular endothelium as a target of beraprost sodium and fenofibrate for antiatherosclerotic therapy in type 2 diabetes mellitus.
Vascular health and risk management.
2005; 1(3):209-15. doi:
. [PMID: 17319106] - Margit Fröhlich, Nadine Albermann, Alexandra Sauer, Ingeborg Walter-Sack, Walter E Haefeli, Johanna Weiss. In vitro and ex vivo evidence for modulation of P-glycoprotein activity by progestins.
Biochemical pharmacology.
2004 Dec; 68(12):2409-16. doi:
10.1016/j.bcp.2004.08.026. [PMID: 15548387] - See Kwok, Peter L Selby, Patrick McElduff, Ian Laing, Bharti Mackness, Michael I Mackness, Hilary Prais, Janet Morgan, Allen P Yates, Paul N Durrington, F Med Sci. Progestogens of varying androgenicity and cardiovascular risk factors in postmenopausal women receiving oestrogen replacement therapy.
Clinical endocrinology.
2004 Dec; 61(6):760-7. doi:
10.1111/j.1365-2265.2004.02166.x. [PMID: 15579192]