Norgestrel (BioDeep_00000402584)

Main id: BioDeep_00000002282

 


代谢物信息卡片


(±)-13-ethyl-17α-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one

化学式: C21H28O2 (312.2089)
中文名称: D-(-)-炔诺孕酮, 炔诺孕酮
谱图信息: 最多检出来源 Homo sapiens(urine) 22.96%

分子结构信息

SMILES: CCC12CCC3C(C1CCC2(C#C)O)CCC4=CC(=O)CCC34
InChI: InChI=1S/C21H28O2/c1-3-20-11-9-17-16-8-6-15(22)13-14(16)5-7-18(17)19(20)10-12-21(20,23)4-2/h2,13,16-19,23H,3,5-12H2,1H3

描述信息

G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03A - Hormonal contraceptives for systemic use > G03AD - Emergency contraceptives
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03A - Hormonal contraceptives for systemic use > G03AC - Progestogens
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents
CONFIDENCE standard compound; INTERNAL_ID 282; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4987; ORIGINAL_PRECURSOR_SCAN_NO 4984
CONFIDENCE standard compound; INTERNAL_ID 282; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5650; ORIGINAL_PRECURSOR_SCAN_NO 5649
CONFIDENCE standard compound; INTERNAL_ID 282; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 4969; ORIGINAL_PRECURSOR_SCAN_NO 4965
CONFIDENCE standard compound; INTERNAL_ID 282; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5035; ORIGINAL_PRECURSOR_SCAN_NO 5034
CONFIDENCE standard compound; INTERNAL_ID 282; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5762; ORIGINAL_PRECURSOR_SCAN_NO 5761
CONFIDENCE standard compound; INTERNAL_ID 282; DATASET 20200303_ENTACT_RP_MIX499; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 5116; ORIGINAL_PRECURSOR_SCAN_NO 5115
CONFIDENCE standard compound; INTERNAL_ID 282; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9309; ORIGINAL_PRECURSOR_SCAN_NO 9307
CONFIDENCE standard compound; INTERNAL_ID 282; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9321; ORIGINAL_PRECURSOR_SCAN_NO 9318
CONFIDENCE standard compound; INTERNAL_ID 282; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9409; ORIGINAL_PRECURSOR_SCAN_NO 9405
CONFIDENCE standard compound; INTERNAL_ID 282; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9359; ORIGINAL_PRECURSOR_SCAN_NO 9356
CONFIDENCE standard compound; INTERNAL_ID 282; DATASET 20200303_ENTACT_RP_MIX503; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9374; ORIGINAL_PRECURSOR_SCAN_NO 9371
CONFIDENCE standard compound; INTERNAL_ID 282; DATASET 20200303_ENTACT_RP_MIX505; DATA_PROCESSING MERGING RMBmix ver. 0.2.7; DATA_PROCESSING PRESCREENING Shinyscreen ver. 0.8.0; ORIGINAL_ACQUISITION_NO 9442; ORIGINAL_PRECURSOR_SCAN_NO 9438
CONFIDENCE standard compound; INTERNAL_ID 2806
CONFIDENCE standard compound; INTERNAL_ID 8737

同义名列表

7 个代谢物同义名

Levonorgestrel; Norgestrel; (±)-13-ethyl-17α-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one; 13-ethyl-17alpha-hydroxy-18,19-dinorpregn-4-en-20-yn-3-one; ST 21:4;O2; Levonorgestrel; Norgestrel



数据库引用编号

43 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

0 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 10 ALB, ANG, BCL2, BGLAP, CYP3A4, PGR, PRL, PTGS2, TBX20, VEGFA
Peripheral membrane protein 1 PTGS2
Endoplasmic reticulum membrane 6 BCL2, CD4, CYP19A1, CYP3A4, PROS1, PTGS2
Nucleus 8 ALB, ANG, BCL2, MKI67, PGR, PRL, TBX20, VEGFA
cytosol 4 ALB, ANG, BCL2, PGR
dendrite 1 BGLAP
nuclear body 1 MKI67
centrosome 1 ALB
nucleoplasm 3 MKI67, PGR, PRL
RNA polymerase II transcription regulator complex 1 PRL
Cell membrane 1 CD4
Multi-pass membrane protein 1 CYP19A1
cell surface 2 PLG, VEGFA
glutamatergic synapse 1 PLG
Golgi apparatus 2 ALB, VEGFA
Golgi membrane 2 INS, PROS1
growth cone 1 ANG
neuronal cell body 1 ANG
plasma membrane 6 CD4, F2, F7, PGR, PLG, PROS1
Membrane 5 BCL2, CYP19A1, CYP3A4, MKI67, VEGFA
caveola 1 PTGS2
extracellular exosome 5 ALB, F2, PLG, PROS1, SERPINA6
endoplasmic reticulum 6 ALB, BCL2, CYP19A1, PROS1, PTGS2, VEGFA
extracellular space 12 ALB, ANG, BGLAP, CXCL8, F2, F7, INS, PLG, PRL, PROS1, SERPINA6, VEGFA
Schaffer collateral - CA1 synapse 1 PLG
adherens junction 1 VEGFA
mitochondrion 1 BCL2
protein-containing complex 3 ALB, BCL2, PTGS2
intracellular membrane-bounded organelle 1 CYP3A4
Microsome membrane 3 CYP19A1, CYP3A4, PTGS2
Single-pass type I membrane protein 1 CD4
Secreted 11 ALB, ANG, BGLAP, CXCL8, F2, F7, INS, PLG, PRL, PROS1, VEGFA
extracellular region 12 ALB, ANG, BGLAP, CXCL8, F2, F7, INS, PLG, PRL, PROS1, SERPINA6, VEGFA
Mitochondrion outer membrane 1 BCL2
Single-pass membrane protein 1 BCL2
mitochondrial outer membrane 2 BCL2, PGR
anchoring junction 1 ALB
Nucleus membrane 1 BCL2
Bcl-2 family protein complex 1 BCL2
nuclear membrane 1 BCL2
external side of plasma membrane 2 CD4, PLG
Secreted, extracellular space, extracellular matrix 1 VEGFA
actin cytoskeleton 1 ANG
perikaryon 1 BGLAP
nucleolus 2 ANG, MKI67
Early endosome 1 CD4
vesicle 2 BGLAP, F7
Membrane raft 1 CD4
pore complex 1 BCL2
extracellular matrix 1 VEGFA
basement membrane 1 ANG
collagen-containing extracellular matrix 3 F2, F7, PLG
secretory granule 1 VEGFA
Nucleus inner membrane 1 PTGS2
Nucleus outer membrane 1 PTGS2
nuclear inner membrane 1 PTGS2
nuclear outer membrane 1 PTGS2
neuron projection 1 PTGS2
ciliary basal body 1 ALB
chromatin 3 PGR, PRL, TBX20
Chromosome 2 ANG, MKI67
centriole 1 ALB
Nucleus, nucleolus 2 ANG, MKI67
spindle pole 1 ALB
blood microparticle 4 ALB, F2, PLG, PROS1
endosome lumen 2 INS, PRL
Cytoplasm, Stress granule 1 ANG
cytoplasmic stress granule 1 ANG
myelin sheath 1 BCL2
secretory granule lumen 1 INS
Golgi lumen 5 BGLAP, F2, F7, INS, PROS1
endoplasmic reticulum lumen 7 ALB, BGLAP, CD4, F2, F7, INS, PTGS2
platelet alpha granule lumen 4 ALB, PLG, PROS1, VEGFA
endocytic vesicle 1 ANG
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
clathrin-coated endocytic vesicle membrane 1 CD4
T cell receptor complex 1 CD4
angiogenin-PRI complex 1 ANG
[Isoform 4]: Mitochondrion outer membrane 1 PGR
serine-type peptidase complex 1 F7
BAD-BCL-2 complex 1 BCL2
[N-VEGF]: Cytoplasm 1 VEGFA
[VEGFA]: Secreted 1 VEGFA
[Isoform L-VEGF189]: Endoplasmic reticulum 1 VEGFA
[Isoform VEGF121]: Secreted 1 VEGFA
[Isoform VEGF165]: Secreted 1 VEGFA
VEGF-A complex 1 VEGFA
ciliary transition fiber 1 ALB


文献列表

  • Jing Liu, Feiyun Tu, Ming Liu, Jichao Wang, Zhibin Zhang. Antifertility effects of EP-1 (quinestrol and levonorgestrel) on Pacific rats (Rattus exulans). Integrative zoology. 2023 Oct; ?(?):. doi: 10.1111/1749-4877.12774. [PMID: 37884475]
  • Andrea Flores-Rodriguez, Fernando Diaz Gonzalez-Colmenero, Mariana Garcia-Leal, Melissa Saenz-Flores, Erick Burciaga-Jimenez, Jorge A Zuñiga-Hernandez, Neri A Alvarez-Villalobos, Rene Rodríguez-Guajardo, Felipe A Morales-Martinez, Luis H Sordia-Hernandez, Rene Rodriguez-Gutierrez. Harms of third- and fourth-generation combined oral contraceptives in premenopausal women: A systematic review and meta-analysis. Journal of investigative medicine : the official publication of the American Federation for Clinical Research. 2023 Jul; ?(?):10815589231184227. doi: 10.1177/10815589231184227. [PMID: 37415461]
  • Zhiming Hu, Yanlin Zhang, Hanqing Jiang, Jiu-An Lv. Bioinspired helical-artificial fibrous muscle structured tubular soft actuators. Science advances. 2023 06; 9(25):eadh3350. doi: 10.1126/sciadv.adh3350. [PMID: 37352358]
  • Rubina Bunjun, Tanko F Ramla, Shameem Z Jaumdally, Laura Noël-Romas, Hossaena Ayele, Bryan P Brown, Hoyam Gamieldien, Rushil Harryparsad, Smritee Dabee, Gonasagrie Nair, Maricianah Onono, Thesla Palanee-Phillips, Catilin W Scoville, Kate B Heller, Jared M Baeten, Steven E Bosinger, Adam Burgener, Jo-Ann S Passmore, Heather Jaspan, Renee Heffron. Initiating Intramuscular Depot Medroxyprogesterone Acetate Increases Frequencies of Th17-like Human Immunodeficiency Virus Target Cells in the Genital Tract of Women in South Africa: A Randomized Trial. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2022 11; 75(11):2000-2011. doi: 10.1093/cid/ciac284. [PMID: 35941737]
  • Chien-Ming Chen, Yun-Ning Tsai, Chien-Hsiun Chen, Yu-Hwei Tseng, Sunny Jui-Shan Lin, Yi-Chang Su. Levonorgestrel intrauterine devices improve body constitution deviations in the perspective of traditional Chinese medicine and quality of life in patients with chronic pelvic pain and heavy menstrual bleeding. Taiwanese journal of obstetrics & gynecology. 2022 Nov; 61(6):989-994. doi: 10.1016/j.tjog.2021.10.012. [PMID: 36428003]
  • Kristina Gemzell-Danielsson, Angelo Cagnacci, Nathalie Chabbert-Buffet, Jonathan Douxfils, Jean-Michel Foidart, Ali Kubba, Luis Ignacio Lete Lasa, Diana Mansour, Joseph Neulen, Jaoquim Neves, Fátima Palma, Thomas Römer, Robert Spaczyński, Vera Tóth. A novel estetrol-containing combined oral contraceptive: European expert panel review. The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception. 2022 Oct; 27(5):373-383. doi: 10.1080/13625187.2022.2093850. [PMID: 35862627]
  • Ramla F Tanko, Rubina Bunjun, Smritee Dabee, Shameem Z Jaumdally, Maricianah Onono, Gonasagrie Nair, Thesla Palanee-Phillips, Rushil Harryparsad, Anna Ursula Happel, Hoyam Gamieldien, Yamkela Qumbelo, Musalula Sinkala, Caitlin W Scoville, Kate Heller, Jared M Baeten, Steven E Bosinger, Adam Burgener, Renee Heffron, Heather B Jaspan, Jo Ann S Passmore. The Effect of Contraception on Genital Cytokines in Women Randomized to Copper Intrauterine Device, Depot Medroxyprogesterone Acetate, or Levonorgestrel Implant. The Journal of infectious diseases. 2022 09; 226(5):907-919. doi: 10.1093/infdis/jiac084. [PMID: 35263421]
  • Ting-Ting Zhao, Li-Li Pang, Lei-Lei Yang, Ruo-Nan Li, Ling-Xiu Fan, Yi Wen. Efficacy of high-intensity focused ultrasound combined with LNG-IUS for adenomyosis: a systematic review and meta-analysis. Archives of gynecology and obstetrics. 2022 Aug; ?(?):. doi: 10.1007/s00404-022-06720-z. [PMID: 35947146]
  • Jianghuan Hua, Biran Zhu, Wei Guo, Xianfeng Wang, Yongyong Guo, Lihua Yang, Jian Han, Bingsheng Zhou. Endocrine disrupting effects induced by levonorgestrel linked to altered DNA methylation in rare minnow (Gobiocypris rarus). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2022 Jul; 257(?):109332. doi: 10.1016/j.cbpc.2022.109332. [PMID: 35351618]
  • Ganesh Cherala, Cara Nelson, Ying Guo, Anubhav Mathur, Thomas Tarnowski, Ahmed A Othman. Evaluation of the potential for pharmacokinetic interaction between tirabrutinib and levonorgestrel/ethinyl estradiol in healthy female volunteers. Clinical and translational science. 2022 06; 15(6):1492-1499. doi: 10.1111/cts.13265. [PMID: 35266297]
  • Noémie Roland, Jérôme Drouin, David Desplas, Lise Duranteau, François Cuenot, Rosemary Dray-Spira, Alain Weill, Mahmoud Zureik. Impact of Coronavirus disease 2019 (COVID-19) on contraception use in 2020 and up until the end of April 2021 in France. Contraception. 2022 04; 108(?):50-55. doi: 10.1016/j.contraception.2021.12.002. [PMID: 34971603]
  • Baorui Wang, Suohui Zhang, Xiaoyu Zhao, Jie Lian, Yunhua Gao. Preparation, characterization, and in vivo evaluation of levonorgestrel-loaded thermostable microneedles. Drug delivery and translational research. 2022 04; 12(4):944-956. doi: 10.1007/s13346-021-01057-7. [PMID: 34515951]
  • Charles M'Poca Charles, Aline Munezero, Luis G Bahamondes, Rodolfo C Pacagnella. Comparison of contraceptive sales before and during the COVID-19 pandemic in Brazil. The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception. 2022 Apr; 27(2):115-120. doi: 10.1080/13625187.2022.2027364. [PMID: 35156489]
  • Matthias Teigeler, Dirk Schaudien, Walter Böhmer, Reinhard Länge, Christoph Schäfers. Effects of the Gestagen Levonorgestrel in a Life Cycle Test with Zebrafish (Danio rerio). Environmental toxicology and chemistry. 2022 03; 41(3):580-591. doi: 10.1002/etc.5008. [PMID: 33539028]
  • Karthik Lingineni, Ayyappa Chaturvedula, Brian Cicali, Rodrigo Cristofoletti, Thomas Wendl, Joachim Hoechel, Joshua D Brown, Valvanera Vozmediano, Stephan Schmidt. Determining the Exposure Threshold for Levonorgestrel Efficacy Using an Integrated Model Based Meta-Analysis Approach. Clinical pharmacology and therapeutics. 2022 02; 111(2):509-518. doi: 10.1002/cpt.2457. [PMID: 34674227]
  • Teodora Pene Dumitrescu, Thomas J Greene, Samit R Joshi, Jianfeng Xu, Mark Johnson, Fiona Halliday, Laurie Butcher, Eric Zimmerman, Lindsey Webster, Theresa T Pham, Max Lataillade, Sherene Min. Lack of pharmacokinetic interaction between the HIV-1 maturation inhibitor GSK3640254 and combination oral contraceptives in healthy women. British journal of clinical pharmacology. 2022 02; 88(4):1704-1712. doi: 10.1111/bcp.15051. [PMID: 34427938]
  • Madelon C Vonk, Alfredo Guillén-Del-Castillo, Michael Kreuter, Mandy Avis, Kristell Marzin, Salome R Mack, Sven Wind, Martina Gahlemann. A Drug-Drug Interaction Study to Investigate the Effect of Nintedanib on the Pharmacokinetics of Microgynon (Ethinylestradiol and Levonorgestrel) in Female Patients with Systemic Sclerosis-Associated Interstitial Lung Disease. European journal of drug metabolism and pharmacokinetics. 2022 Jan; 47(1):81-89. doi: 10.1007/s13318-021-00728-7. [PMID: 34664183]
  • Le-Kai Nie, Hong-Li Zou, Lei Cheng, Pei-Hai Zhang. Subcutaneous etonogestrel implant combined with endometrial ablation for the treatment of adenomyosis: two case reports. The journal of obstetrics and gynaecology research. 2022 Jan; 48(1):262-265. doi: 10.1111/jog.15084. [PMID: 34713941]
  • Wendy Ankrom, Deanne Jackson Rudd, Saijuan Zhang, Kerry L Fillgrove, Kezia N Gravesande, Randolph P Matthews, Darin Brimhall, S Aubrey Stoch, Marian N Iwamoto. A phase 1, open-label study to evaluate the drug interaction between islatravir (MK-8591) and the oral contraceptive levonorgestrel/ethinyl estradiol in healthy adult females. Journal of the International AIDS Society. 2021 12; 24(12):e25858. doi: 10.1002/jia2.25858. [PMID: 34935295]
  • Mingxiang Liao, Krzysztof G Jeziorski, Monika Tomaszewska-Kiecana, István Láng, Marek Jasiówka, Viera Skarbová, Piotr Centkowski, Rodryg Ramlau, Maria Górnaś, John Lee, Sarah Edwards, Jenn Habeck, Eileen Nash, Nikolay Grechko, Jim J Xiao. A phase 1, open-label, drug-drug interaction study of rucaparib with rosuvastatin and oral contraceptives in patients with advanced solid tumors. Cancer chemotherapy and pharmacology. 2021 11; 88(5):887-897. doi: 10.1007/s00280-021-04338-7. [PMID: 34370076]
  • Kathryn E Fay, Amelia C Clement, Alexandra Gero, Jennifer E Kaiser, Jessica N Sanders, Abena A BakenRa, David K Turok. Rates of pregnancy among levonorgestrel and copper intrauterine emergency contraception initiators: Implications for backup contraception recommendations. Contraception. 2021 11; 104(5):561-566. doi: 10.1016/j.contraception.2021.06.011. [PMID: 34166648]
  • Eka R Gunardi, Raymond Surya, Inayah Syafitri, Yogi Pasidri. Impact of one-rod levonorgestrel implant on the blood chemistry profile. Scientific reports. 2021 10; 11(1):20141. doi: 10.1038/s41598-021-99801-z. [PMID: 34635768]
  • Li Zhang, Cheng Li, Danni Yang, Yuhua Wang, Yongping Yang, Xudong Sun. Genome-Wide Analysis of the TCP Transcription Factor Genes in Dendrobium catenatum Lindl. International journal of molecular sciences. 2021 Sep; 22(19):. doi: 10.3390/ijms221910269. [PMID: 34638610]
  • Andreas B Jordy, Muna Albayaty, Astrid Breitschaft, Thomas W Anderson, Erik Christiansen, Azadeh Houshmand-Øregaard, Easwaran Manigandan, Tine A Bækdal. Effect of Oral Semaglutide on the Pharmacokinetics of Levonorgestrel and Ethinylestradiol in Healthy Postmenopausal Women and Furosemide and Rosuvastatin in Healthy Subjects. Clinical pharmacokinetics. 2021 09; 60(9):1171-1185. doi: 10.1007/s40262-020-00976-x. [PMID: 33782832]
  • Kristina Gemzell-Danielsson, Ali Kubba, Cecilia Caetano, Thomas Faustmann, Eeva Lukkari-Lax, Oskari Heikinheimo. More than just contraception: the impact of the levonorgestrel-releasing intrauterine system on public health over 30 years. BMJ sexual & reproductive health. 2021 07; 47(3):228-230. doi: 10.1136/bmjsrh-2020-200962. [PMID: 33514606]
  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Claudia Moreira de Brito, Maria Edna de Melo, Marcio C Mancini, Marco Aurelio Santo, Cintia Cercato. Pharmacokinetics of oral levonorgestrel and ethinylestradiol in women after Roux-en-Y gastric bypass surgery. Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery. 2021 Apr; 17(4):673-681. doi: 10.1016/j.soard.2020.12.007. [PMID: 33547015]
  • Christine Klipping, Ingrid Duijkers, Marie Mawet, Catherine Maillard, Adriana Bastidas, Maud Jost, Jean-Michel Foidart. Endocrine and metabolic effects of an oral contraceptive containing estetrol and drospirenone. Contraception. 2021 04; 103(4):213-221. doi: 10.1016/j.contraception.2021.01.001. [PMID: 33428907]
  • Giovanni Grandi, Maria Chiara Del Savio, Fabio Facchinetti. The paradigm of norgestimate: a third-generation testosterone-derivative progestin with a peripheral anti-androgenic activity and the lowest risk of venous thromboembolism. Expert review of clinical pharmacology. 2021 Feb; 14(2):211-224. doi: 10.1080/17512433.2021.1878876. [PMID: 33464138]
  • David K Turok, Alexandra Gero, Rebecca G Simmons, Jennifer E Kaiser, Gregory J Stoddard, Corinne D Sexsmith, Lori M Gawron, Jessica N Sanders. Levonorgestrel vs. Copper Intrauterine Devices for Emergency Contraception. The New England journal of medicine. 2021 01; 384(4):335-344. doi: 10.1056/nejmoa2022141. [PMID: 33503342]
  • Niaree G Hopelian, Rebecca G Simmons, Jessica N Sanders, Katherine Ward, Sabrina Malone Jenkins, Eve Espey, David K Turok. Comparison of levonorgestrel level and creamatocrit in milk following immediate versus delayed postpartum placement of the levonorgestrel IUD. BMC women's health. 2021 01; 21(1):33. doi: 10.1186/s12905-021-01179-7. [PMID: 33478494]
  • Andrea Henkel, Lisa M Goldthwaite. Management of bothersome bleeding associated with progestin-based long-acting reversible contraception: a review. Current opinion in obstetrics & gynecology. 2020 12; 32(6):408-415. doi: 10.1097/gco.0000000000000664. [PMID: 32889971]
  • Birte Maria Hofmann, Dan Apter, Johannes Bitzer, Isabel Reinecke, Marco Serrani, Joachim Höchel, Martin Merz. Comparative pharmacokinetic analysis of levonorgestrel-releasing intrauterine systems and levonorgestrel-containing contraceptives with oral or subdermal administration route. The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception. 2020 Dec; 25(6):417-426. doi: 10.1080/13625187.2020.1815008. [PMID: 33006493]
  • Alaa E A Moubasher, Hisham A Abdel Basset, Asmaa A M Khalil, Eman M K Youssef. Levonorgestrel vs combined oral contraceptive pills in treatment of female acne and hirsutism. Dermatologic therapy. 2020 11; 33(6):e13700. doi: 10.1111/dth.13700. [PMID: 32713062]
  • R Nave, J Höchel, U Mellinger, A Kohnke, J Elliesen, H Schmitz. Pearl Index study with levonorgestrel-releasing intravaginal rings: using pharmacokinetic results to investigate treatment compliance as a potential contributor for contraceptive failure. Human reproduction (Oxford, England). 2020 11; 35(11):2515-2523. doi: 10.1093/humrep/deaa195. [PMID: 32914172]
  • Jan de Jong, Anna Mitselos, Wojciech Jurczak, Raul Cordoba, Carlos Panizo, Tomasz Wrobel, Monika Dlugosz-Danecka, James Jiao, Juthamas Sukbuntherng, Daniele Ouellet, Peter Hellemans. Ibrutinib does not have clinically relevant interactions with oral contraceptives or substrates of CYP3A and CYP2B6. Pharmacology research & perspectives. 2020 10; 8(5):e00649. doi: 10.1002/prp2.649. [PMID: 32945596]
  • R R Campos, T Baêta, A Silva-Filho, S M Rezende, A L L Rocha. Use of a levonorgestrel 52-mg intrauterine system in the control of abnormal uterine bleeding in women with inherited bleeding disorders. Contraception. 2020 10; 102(4):254-258. doi: 10.1016/j.contraception.2020.05.009. [PMID: 32470465]
  • Wendy Ankrom, Jialin Xu, Marie-Helene Vallee, Marissa F Dockendorf, Danielle Armas, Ramesh Boinpally, K Chris Min. Atogepant Has No Clinically Relevant Effects on the Pharmacokinetics of an Ethinyl Estradiol/Levonorgestrel Oral Contraceptive in Healthy Female Participants. Journal of clinical pharmacology. 2020 09; 60(9):1157-1165. doi: 10.1002/jcph.1610. [PMID: 32297990]
  • O S Michael, C L Dibia, O A Adeyanju, K S Olaniyi, E D Areola, L A Olatunji. Estrogen-progestin oral contraceptive and nicotine exposure synergistically confers cardio-renoprotection in female Wistar rats. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. 2020 Sep; 129(?):110387. doi: 10.1016/j.biopha.2020.110387. [PMID: 32540646]
  • Eva Lundström, Ivana Virijevic, Gunnar Söderqvist. Progestogen addition with low-dose levonorgestrel intrauterine system in menopausal hormone treatment gives less normal breast tissue proliferation than oral norethisterone acetate or medroxyprogesterone acetate. Hormone molecular biology and clinical investigation. 2020 Jul; 41(3):. doi: 10.1515/hmbci-2019-0051. [PMID: 32735552]
  • Charlotte Ginstman, Helena Kopp Kallner, Johanna Fagerberg-Silwer, Björn Carlsson, Andreas Ärlemalm, Ylva Böttiger, Jan Brynhildsen. Pharmacokinetics of Oral Levonorgestrel in Women After Roux-en-Y Gastric Bypass Surgery and in BMI-Matched Controls. Obesity surgery. 2020 06; 30(6):2217-2224. doi: 10.1007/s11695-020-04447-x. [PMID: 32030619]
  • Peng Yu, Zhuo Chen, Haochi Zhao, Ruidong Cao, Lingyun Chen, Junhu Su, Yingzhi Ning. Exposure to quinestrol and levonorgestrel affects maternal behavior and offspring development in midday gerbil (Meriones meridianus). Physiology & behavior. 2020 05; 219(?):112848. doi: 10.1016/j.physbeh.2020.112848. [PMID: 32088172]
  • Catherine S Todd, Heidi E Jones, Nontokozo Langwenya, Donald R Hoover, Pai-Lien Chen, Gregory Petro, Landon Myer. Safety and continued use of the levonorgestrel intrauterine system as compared with the copper intrauterine device among women living with HIV in South Africa: A randomized controlled trial. PLoS medicine. 2020 05; 17(5):e1003110. doi: 10.1371/journal.pmed.1003110. [PMID: 32442189]
  • Paula M Castaño, Carolyn L Westhoff. Experience with same-day placement of the 52 mg levonorgestrel-releasing intrauterine system. American journal of obstetrics and gynecology. 2020 04; 222(4S):S883.e1-S883.e6. doi: 10.1016/j.ajog.2019.12.268. [PMID: 31945336]
  • Deborah Margatho, Nelsilene Mota Carvalho, Luis Bahamondes. Endometriosis-associated pain scores and biomarkers in users of the etonogestrel-releasing subdermal implant or the 52-mg levonorgestrel-releasing intrauterine system for up to 24 months. The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception. 2020 Apr; 25(2):133-140. doi: 10.1080/13625187.2020.1725461. [PMID: 32069126]
  • Giordana C Braga, Milena B Brito, Rui A Ferriani, Luciana C Oliveira, Andrea A Garcia, Maria C Pintão, Carolina S Vieira. Effect of the levonorgestrel-releasing intrauterine system on cardiovascular risk markers among women with thrombophilia or previous venous thromboembolism. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 2020 Mar; 148(3):381-385. doi: 10.1002/ijgo.13070. [PMID: 31778208]
  • Cristina García-Beltran, Ruben Cereijo, Tania Quesada-López, Rita Malpique, Abel López-Bermejo, Francis de Zegher, Lourdes Ibáñez, Francesc Villarroya. Reduced circulating levels of chemokine CXCL14 in adolescent girls with polycystic ovary syndrome: normalization after insulin sensitization. BMJ open diabetes research & care. 2020 02; 8(1):. doi: 10.1136/bmjdrc-2019-001035. [PMID: 32107266]
  • Na Liang, Wenfeng Zhang, Hongjiang Wang, Wei Shi, Li Wang, Lijuan Ma. Levonorgestrel Ameliorates Adenomyosis via lncRNA H19/miR-17/TLR4 Pathway. Drug design, development and therapy. 2020; 14(?):3449-3460. doi: 10.2147/dddt.s248095. [PMID: 32921982]
  • Mina Amiri, Fatemeh Nahidi, Razieh Bidhendi-Yarandi, Davood Khalili, Maryam Tohidi, Fahimeh Ramezani Tehrani. A comparison of the effects of oral contraceptives on the clinical and biochemical manifestations of polycystic ovary syndrome: a crossover randomized controlled trial. Human reproduction (Oxford, England). 2020 01; 35(1):175-186. doi: 10.1093/humrep/dez255. [PMID: 31916574]
  • Lukasz Panasowiec, Maja Kufelnicka-Babout, Piotr Sieroszewski. Right-sided ovarian ectopic pregnancy with Jaydess in situ. Ginekologia polska. 2020 ; 91(5):294. doi: 10.5603/gp.2020.0059. [PMID: 32495937]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Rena C Patel, Randy M Stalter, Katherine K Thomas, Bani Tamraz, Steven W Blue, David W Erikson, Christina J Kim, Edward J Kelly, Kavita Nanda, Athena P Kourtis, Jairam R Lingappa, Nelly Mugo, Jared M Baeten, Kimberly K Scarsi. A pharmacokinetic and pharmacogenetic evaluation of contraceptive implants and antiretroviral therapy among women in Kenya and Uganda. AIDS (London, England). 2019 11; 33(13):1995-2004. doi: 10.1097/qad.0000000000002308. [PMID: 31306173]
  • Kehinde Samuel Olaniyi, Lawrence Aderemi Olatunji. Oral ethinylestradiol-levonorgestrel normalizes fructose-induced hepatic lipid accumulation and glycogen depletion in female rats. Canadian journal of physiology and pharmacology. 2019 Nov; 97(11):1042-1052. doi: 10.1139/cjpp-2019-0037. [PMID: 31336054]
  • Sarah Philip, Anthony H Taylor, Justin C Konje, Marwan Habiba. The levonorgestrel-releasing intrauterine device induces endometrial decidualisation in women on tamoxifen. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology. 2019 Nov; 39(8):1117-1122. doi: 10.1080/01443615.2019.1587600. [PMID: 31195902]
  • Qianqian Su, Yi Chen, Jiao Qin, Hongjun Li, Ming Liu, Zhibin Zhang, Quansheng Liu. Ratio-dependent effects of quinestrol and levonorgestrel compounds (EP-1) on reproductive parameters of adult male Swiss mice. Pesticide biochemistry and physiology. 2019 Oct; 160(?):181-186. doi: 10.1016/j.pestbp.2019.08.009. [PMID: 31519253]
  • Teresa Barcellos, Melissa Natavio, Frank Z Stanczyk, Dandan Luo, William J Jusko, Nicole M Bender. Effects of ritonavir-boosted protease inhibitors on combined oral contraceptive pharmacokinetics and pharmacodynamics in HIV-positive women. Contraception. 2019 10; 100(4):283-287. doi: 10.1016/j.contraception.2019.06.002. [PMID: 31194965]
  • Adeyanju Oluwaseun Aremu, Dibia Chinaza Lilian, Soladoye Ayodele Olufemi, Olatunji Lawrence Aderemi. Combined but not single treatment with ethinylestradiol/levonorgestrel and spironolactone reduces plasminogen activator inhibitor-1 in insulin-resistant ovariectomised rats. Journal of the renin-angiotensin-aldosterone system : JRAAS. 2019 Oct; 20(4):1470320319895933. doi: 10.1177/1470320319895933. [PMID: 31856649]
  • Herman T Depypere, Frank Z Stanczyk, Siska Croubels, Phillip N Blondeel, Nathalie A Roche, Bernard P Depypere, Lynn Vanhaecke. Breast levonorgestrel concentrations in women using a levonorgestrel-releasing intrauterine system. Contraception. 2019 10; 100(4):299-301. doi: 10.1016/j.contraception.2019.07.002. [PMID: 31302122]
  • Lei Li, Jinhua Leng, Shuangzheng Jia, Jinghe Lang. Treatment of symptomatic adenomyosis with the levonorgestrel-releasing intrauterine system. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 2019 Sep; 146(3):357-363. doi: 10.1002/ijgo.12887. [PMID: 31194884]
  • . Screening and Management of Bleeding Disorders in Adolescents With Heavy Menstrual Bleeding: ACOG COMMITTEE OPINION SUMMARY, Number 785. Obstetrics and gynecology. 2019 09; 134(3):658-659. doi: 10.1097/aog.0000000000003412. [PMID: 31441820]
  • Sandy Abujrais, Matts Olovsson, Martin Ahnoff, Annica J Rasmusson, Anders Larsson, Torbjörn Åkerfeldt, Kim Kultima. A sensitive method detecting trace levels of levonorgestrel using LC-HRMS. Contraception. 2019 09; 100(3):247-249. doi: 10.1016/j.contraception.2019.06.001. [PMID: 31216423]
  • . Screening and Management of Bleeding Disorders in Adolescents With Heavy Menstrual Bleeding: ACOG COMMITTEE OPINION, Number 785. Obstetrics and gynecology. 2019 09; 134(3):e71-e83. doi: 10.1097/aog.0000000000003411. [PMID: 31441825]
  • Oluwaseun A Adeyanju, Lawrence A Olatunji. Drospirenone-containing oral contraceptives do not affect glucose regulation and circulating corticosterone. Journal of basic and clinical physiology and pharmacology. 2019 Aug; 30(5):. doi: 10.1515/jbcpp-2018-0184. [PMID: 31469652]
  • Olufunto O Badmus, Lawrence A Olatunji. Involvement of glucocorticoid and mineralocorticoid receptors in lipid accumulation and depressed G6PD activity in the livers of rats treated with postpartum oral estrogen-progestin. Naunyn-Schmiedeberg's archives of pharmacology. 2019 08; 392(8):913-924. doi: 10.1007/s00210-019-01634-1. [PMID: 30903201]
  • Saika Manzoor, Mohd Ashraf Ganie, Shajrul Amin, Zaffar A Shah, Imtiyaz A Bhat, S Douhath Yousuf, Humira Jeelani, Iram A Kawa, Qudsia Fatima, Fouzia Rashid. Oral contraceptive use increases risk of inflammatory and coagulatory disorders in women with Polycystic Ovarian Syndrome: An observational study. Scientific reports. 2019 07; 9(1):10182. doi: 10.1038/s41598-019-46644-4. [PMID: 31308416]
  • László Kardos, Gabriella Magyar, Eszter Schváb, Eva Luczai. Levonorgestrel emergency contraception and bodyweight. Current medical research and opinion. 2019 07; 35(7):1149-1155. doi: 10.1080/03007995.2018.1560250. [PMID: 30569769]
  • Rüdiger Nave, Uwe Mellinger, Stefan Klein, Joachim Höchel, Heinz Schmitz. Absence of Drug-Drug Interaction of Anastrozole on Levonorgestrel Delivered Simultaneously by an Intravaginal Ring: Results of a Phase 2 Trial. Journal of clinical pharmacology. 2019 07; 59(7):1022-1028. doi: 10.1002/jcph.1396. [PMID: 30791125]
  • Athena P Kourtis, Jeffrey Wiener, Stacey Hurst, Julie A E Nelson, Mackenzie L Cottrell, Amanda Corbett, Lameck Chinula, Albans Msika, Lisa B Haddad, Jennifer H Tang. Brief Report: HIV Shedding in the Female Genital Tract of Women on ART and Progestin Contraception: Extended Follow-up Results of a Randomized Clinical Trial. Journal of acquired immune deficiency syndromes (1999). 2019 06; 81(2):163-165. doi: 10.1097/qai.0000000000002011. [PMID: 31095006]
  • Mohammad Mofidfar, Laura O'Farrell, Mark R Prausnitz. Pharmaceutical jewelry: Earring patch for transdermal delivery of contraceptive hormone. Journal of controlled release : official journal of the Controlled Release Society. 2019 05; 301(?):140-145. doi: 10.1016/j.jconrel.2019.03.011. [PMID: 30876952]
  • Cheng Li, Yan-Ting Wu, Qian Zhu, Hui-Yu Zhang, Zhen Huang, Duo Zhang, Hang Qi, Gui-Ling Liang, Xiao-Qing He, Xiao-Feng Wang, Xue Tang, He-Feng Huang, Jian Zhang. TRPV4 is involved in levonorgestrel-induced reduction in oviduct ciliary beating. The Journal of pathology. 2019 05; 248(1):77-87. doi: 10.1002/path.5233. [PMID: 30632164]
  • Huadi Yang, Xuqun Xu, Xuelu Jiang, Zhitao Yao. Treatment of menorrhagia due to aplastic anemia by hysteroscopic resection of endometrial functional layer and levonorgestrel-releasing intra-uterine system: Three case reports. Medicine. 2019 Apr; 98(17):e15156. doi: 10.1097/md.0000000000015156. [PMID: 31027059]
  • Mohamed-Eslam F Mohamed, Sheryl Trueman, Tian Feng, Alan Friedman, Ahmed A Othman. The JAK1 Inhibitor Upadacitinib Has No Effect on the Pharmacokinetics of Levonorgestrel and Ethinylestradiol: A Study in Healthy Female Subjects. Journal of clinical pharmacology. 2019 04; 59(4):510-516. doi: 10.1002/jcph.1350. [PMID: 30500075]
  • Yanfei Gao, Shuzhi Shan, Xin Zhao, Jing Jiang, Dongxiao Li, Bin Shi. Clinical efficacy of adenomyomectomy using "H" type incision combined with Mirena in the treatment of adenomyosis. Medicine. 2019 Mar; 98(11):e14579. doi: 10.1097/md.0000000000014579. [PMID: 30882624]
  • Wei Li, Richard N Terry, Jie Tang, Meihua R Feng, Steven P Schwendeman, Mark R Prausnitz. Rapidly separable microneedle patch for the sustained release of a contraceptive. Nature biomedical engineering. 2019 03; 3(3):220-229. doi: 10.1038/s41551-018-0337-4. [PMID: 30948808]
  • Jenna N Parrish, Megan L Bertholomey, Hong W Pang, Robert C Speth, Mary M Torregrossa. Estradiol modulation of the renin-angiotensin system and the regulation of fear extinction. Translational psychiatry. 2019 01; 9(1):36. doi: 10.1038/s41398-019-0374-0. [PMID: 30696810]
  • Lyndsey R Buckner, Erma Z Drobnis, Molly S Augustine, Lynette K Rogers, Jill Akers, Patricia D Mott, Thomas J Hope, Alison J Quayle, Danny J Schust. Cervical and systemic concentrations of long acting hormonal contraceptive (LARC) progestins depend on delivery method: Implications for the study of HIV transmission. PloS one. 2019; 14(5):e0214152. doi: 10.1371/journal.pone.0214152. [PMID: 31095572]
  • Xinhua Yang, Xiaofei Zhang, Bin Lin, Xiao Feng, Aixingzi Aili. Combined therapeutic effects of HIFU, GnRH-a and LNG-IUS for the treatment of severe adenomyosis. International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group. 2019; 36(1):486-492. doi: 10.1080/02656736.2019.1595179. [PMID: 30994010]
  • Tolulope Eniola Omolekulo, Olugbenga Samuel Michael, Lawrence Aderemi Olatunji. Sodium acetate improves disrupted glucoregulation and hepatic triglyceride content in insulin-resistant female rats: involvement of adenosine deaminase and dipeptidyl peptidase-4 activities. Naunyn-Schmiedeberg's archives of pharmacology. 2019 01; 392(1):103-116. doi: 10.1007/s00210-018-1569-2. [PMID: 30280312]
  • Kehinde Samuel Olaniyi, Lawrence Aderemi Olatunji. Oral ethinylestradiol-levonorgestrel attenuates cardiac glycogen and triglyceride accumulation in high fructose female rats by suppressing pyruvate dehydrogenase kinase-4. Naunyn-Schmiedeberg's archives of pharmacology. 2019 01; 392(1):89-101. doi: 10.1007/s00210-018-1568-3. [PMID: 30276420]
  • Alison B Edelman, Jeffrey T Jensen, Sara McCrimmon, Marci Messerle-Forbes, Andrea O'Donnell, Jon D Hennebold. Combined oral contraceptive interference with the ability of ulipristal acetate to delay ovulation: A prospective cohort study. Contraception. 2018 12; 98(6):463-466. doi: 10.1016/j.contraception.2018.08.003. [PMID: 30118684]
  • Zhenqi Liu, Shunchen Qiu, Yiqun Gu, Meiying Ning. Quantitative determination of levonorgestrel in beagle dog plasma after vaginal administration of intravaginal ring by high-performance liquid chromatography-tandem mass spectrometry. Biomedical chromatography : BMC. 2018 Dec; 32(12):e4367. doi: 10.1002/bmc.4367. [PMID: 30120779]
  • Nese Yucel, Erdem Baskent, Burcin Karamustafaoglu Balci, Gokhan Goynumer. The levonorgestrel-releasing intrauterine system is associated with a reduction in dysmenorrhoea and dyspareunia, a decrease in CA 125 levels, and an increase in quality of life in women with suspected endometriosis. The Australian & New Zealand journal of obstetrics & gynaecology. 2018 10; 58(5):560-563. doi: 10.1111/ajo.12773. [PMID: 29359457]
  • Deborah Margatho, Nelsilene Mota Carvalho, Larissa Eloy, Luis Bahamondes. Assessment of biomarkers in women with endometriosis-associated pain using the ENG contraceptive implant or the 52 mg LNG-IUS: a non-inferiority randomised clinical trial. The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception. 2018 Oct; 23(5):344-350. doi: 10.1080/13625187.2018.1531117. [PMID: 30372645]
  • Jessica K Hartman, Tyler Beames, Bethany Parks, Daniel Doheny, Gina Song, Alina Efremenko, Miyoung Yoon, Briana Foley, Chad Deisenroth, Patrick D McMullen, Rebecca A Clewell. An in vitro approach for prioritization and evaluation of chemical effects on glucocorticoid receptor mediated adipogenesis. Toxicology and applied pharmacology. 2018 09; 355(?):112-126. doi: 10.1016/j.taap.2018.05.016. [PMID: 29782964]
  • Cassia R T Juliato, Paulo Stahlschmidt, Arlete Fernandes, Ilza Monteiro, Luis Bahamondes. A case series on the use of levonorgestrel 52 mg intrauterine system after organ transplant. Contraception. 2018 09; 98(3):252-254. doi: 10.1016/j.contraception.2018.04.017. [PMID: 29746814]
  • Jianbo Wu, Yuxiu Huang, Lihong Chen, Jifen Hu, Yilu Zou. Treatment of Adenomyosis with Subcutaneous Etonogestrel Implants: A Clinical Observational Study in 17 Patients. Medical science monitor : international medical journal of experimental and clinical research. 2018 Sep; 24(?):6085-6092. doi: 10.12659/msm.908979. [PMID: 30171680]
  • Joe-Elie Salem, Pauline Dureau, Anne Bachelot, Marine Germain, Pascal Voiriot, Bruno Lebourgeois, David-Alexandre Trégouët, Jean-Sébastien Hulot, Christian Funck-Brentano. Association of Oral Contraceptives With Drug-Induced QT Interval Prolongation in Healthy Nonmenopausal Women. JAMA cardiology. 2018 09; 3(9):877-882. doi: 10.1001/jamacardio.2018.2251. [PMID: 30073300]
  • Oluwaseun A Adeyanju, Olaniyi A Soetan, Ayodele O Soladoye, Lawrence A Olatunji. Oral hormonal therapy with ethinylestradiol-levonorgestrel improves insulin resistance, obesity, and glycogen synthase kinase-3 independent of circulating mineralocorticoid in estrogen-deficient rats. Canadian journal of physiology and pharmacology. 2018 Jun; 96(6):577-586. doi: 10.1139/cjpp-2017-0630. [PMID: 29400073]
  • Lauren R Cirrincione, Sujan Dilly Penchala, Kimberly K Scarsi, Anthony T Podany, Lee C Winchester, David J Back, Saye H Khoo, Courtney V Fletcher, Marco Siccardi, Laura J Else. Development, validation and utilization of a highly sensitive LC-MS/MS method for quantification of levonorgestrel released from a subdermal implant in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 2018 May; 1084(?):106-112. doi: 10.1016/j.jchromb.2018.03.023. [PMID: 29579732]
  • Jude Moutchia-Suh, Dave-King Moutourou Mouemba, Calypse Asangbe Ngwasiri. Occurrence of anembryonic pregnancy with use of levonorgestrel subdermal implant (JADELLE®): a case report. Journal of medical case reports. 2018 Apr; 12(1):111. doi: 10.1186/s13256-018-1675-2. [PMID: 29704897]
  • Rüdiger Nave, Tero Jalkanen, Christine Talling, Masato Kaneko, Shunji Matsuki, Joachim Höchel. The Effect of Drug Content Reduction on the In Vitro and In Vivo Properties of Levonorgestrel-Releasing Intravaginal Rings. Journal of pharmaceutical sciences. 2018 04; 107(4):1020-1027. doi: 10.1016/j.xphs.2017.11.009. [PMID: 29175414]
  • Owain Roberts, Rajith K R Rajoli, David J Back, Andrew Owen, Kristin M Darin, Courtney V Fletcher, Mohammed Lamorde, Kimberly K Scarsi, Marco Siccardi. Physiologically based pharmacokinetic modelling prediction of the effects of dose adjustment in drug-drug interactions between levonorgestrel contraceptive implants and efavirenz-based ART. The Journal of antimicrobial chemotherapy. 2018 04; 73(4):1004-1012. doi: 10.1093/jac/dkx515. [PMID: 29365101]
  • Tyler Frankel, Lance Yonkos, Franklin Ampy, Jack Frankel. Exposure to levonorgestrel increases nest acquisition success and decreases sperm motility in the male fathead minnow (Pimephales promelas). Environmental toxicology and chemistry. 2018 04; 37(4):1131-1137. doi: 10.1002/etc.4054. [PMID: 29215767]
  • Anuli N Nwaohiri, Jennifer H Tang, Frank Stanczyk, Lameck Chinula, Stacey Hurst, Nicole L Davis, Gerald Tegha, Lisa Haddad, Athena P Kourtis. Discordance between self-reported contraceptive use and detection of exogenous hormones among Malawian women enrolling in a randomized clinical trial. Contraception. 2018 04; 97(4):354-356. doi: 10.1016/j.contraception.2017.12.007. [PMID: 29246819]
  • Lisa H Nowell, Patrick W Moran, Travis S Schmidt, Julia E Norman, Naomi Nakagaki, Megan E Shoda, Barbara J Mahler, Peter C Van Metre, Wesley W Stone, Mark W Sandstrom, Michelle L Hladik. Complex mixtures of dissolved pesticides show potential aquatic toxicity in a synoptic study of Midwestern U.S. streams. The Science of the total environment. 2018 Feb; 613-614(?):1469-1488. doi: 10.1016/j.scitotenv.2017.06.156. [PMID: 28802893]
  • Alison J Eastman, Ingrid L Bergin, Daniel Chai, Christine M Bassis, William LeBar, George O Oluoch, Emma R Liechty, Atunga Nyachieo, Vincent B Young, David M Aronoff, Dorothy L Patton, Jason D Bell. Impact of the Levonorgestrel-Releasing Intrauterine System on the Progression of Chlamydia trachomatis Infection to Pelvic Inflammatory Disease in a Baboon Model. The Journal of infectious diseases. 2018 01; 217(4):656-666. doi: 10.1093/infdis/jix545. [PMID: 29253201]
  • Rüdiger Nave, Stefan Klein, André Müller, Xinying Chang, Joachim Höchel. Absence of Effect of Intravaginal Miconazole, Clindamycin, Nonoxynol-9, and Tampons on the Pharmacokinetics of an Anastrozole/Levonorgestrel Intravaginal Ring. Journal of clinical pharmacology. 2018 Jan; 58(1):97-106. doi: 10.1002/jcph.984. [PMID: 28783867]
  • Crista Johnson-Agbakwu, Louise Brown, James Yuan, Robert Kissling, David J Greenblatt. Effects of Flibanserin on the Pharmacokinetics of a Combined Ethinylestradiol/Levonorgestrel Oral Contraceptive in Healthy Premenopausal Women: A Randomized Crossover Study. Clinical therapeutics. 2018 01; 40(1):64-73. doi: 10.1016/j.clinthera.2017.08.021. [PMID: 29198449]
  • Sung Woo Kim, Hoon Kim, Seung-Yup Ku, Chang Suk Suh, Seok Hyun Kim, Young Min Choi. A successful live birth with in vitro fertilization and thawed embryo transfer after conservative treatment of recurrent endometrial cancer. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2018 Jan; 34(1):15-19. doi: 10.1080/09513590.2017.1342239. [PMID: 28650773]