ALFENTANIL (BioDeep_00000398415)
Main id: BioDeep_00000001883
代谢物信息卡片
ALFENTANIL
化学式: C21H32N6O3 (416.2536)
中文名称: 阿芬太尼
谱图信息:
最多检出来源 () 0%
分子结构信息
SMILES: CCC(=O)N(C1=CC=CC=C1)C2(CCN(CC2)CCN3C(=O)N(N=N3)CC)COC
InChI: InChI=1S/C21H32N6O3/c1-4-19(28)27(18-9-7-6-8-10-18)21(17-30-3)11-13-24(14-12-21)15-16-26-20(29)25(5-2)22-23-26/h6-10H,4-5,11-17H2,1-3H3
描述信息
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
N - Nervous system > N01 - Anesthetics > N01A - Anesthetics, general > N01AH - Opioid anesthetics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D002491 - Central Nervous System Agents > D000700 - Analgesics
同义名列表
2 个代谢物同义名
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:2569
- KEGG: C08005
- KEGGdrug: D07122
- PubChem: 51263
- DrugBank: DB00802
- ChEMBL: CHEMBL634
- MeSH: Alfentanil
- CAS: 71195-58-9
- MoNA: CO000040
- MoNA: CO000039
- MoNA: CO000038
- MoNA: CO000037
- MoNA: CO000036
- PubChem: 10205
- NIKKAJI: J330.279B
- RefMet: Alfentanil
- KNApSAcK: 2569
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark S Wallace. Effect of Pregabalin on the Median Effective Plasma Concentration of Intravenous Alfentanil in Capsaicin-Induced Pain.
Pain medicine (Malden, Mass.).
2021 Dec; 22(12):3072-3079. doi:
10.1093/pm/pnab222. [PMID: 34329455] - Jean Jung, Allan Kolodziej, Elise Pape, Michael Bisch, Lucie Javot, Valérie Gibaja, Jean-Yves Jouzeau, Julien Scala-Bertola, Nicolas Gambier. Multiplex detection of 14 fentanyl analogues and U-47700 in biological samples: Application to a panel of French hospitalized patients.
Forensic science international.
2020 Dec; 317(?):110437. doi:
10.1016/j.forsciint.2020.110437. [PMID: 33007729] - Robert J Brosnan, Bruno H Pypendop, Scott D Stanley. Phenylpiperidine opioid effects on isoflurane minimum alveolar concentration in cats.
Journal of veterinary pharmacology and therapeutics.
2020 Nov; 43(6):533-537. doi:
10.1111/jvp.12886. [PMID: 32557697] - Haruka Tsutsui, Motohiro Kato, Shino Kuramoto, Nobuo Sekiguchi, Hidetoshi Shindoh, Kazuhisa Ozeki. Quantitative evaluation of hepatic and intestinal induction of CYP3A in clinical practice.
Xenobiotica; the fate of foreign compounds in biological systems.
2020 Aug; 50(8):875-884. doi:
10.1080/00498254.2019.1710620. [PMID: 31885304] - Khaled Abduljalil, Xian Pan, Amita Pansari, Masoud Jamei, Trevor N Johnson. Preterm Physiologically Based Pharmacokinetic Model. Part II: Applications of the Model to Predict Drug Pharmacokinetics in the Preterm Population.
Clinical pharmacokinetics.
2020 04; 59(4):501-518. doi:
10.1007/s40262-019-00827-4. [PMID: 31587145] - Jing-Yang Liou, Mei-Yung Tsou, Shinju Obara, Lu Yu, Chien-Kun Ting. Plasma concentration based response surface model predict better than effect-site concentration based model for wake-up time during gastrointestinal endoscopy sedation.
Journal of the Formosan Medical Association = Taiwan yi zhi.
2019 Jan; 118(1 Pt 2):291-298. doi:
10.1016/j.jfma.2018.05.007. [PMID: 29803320] - Nina Hanke, Sebastian Frechen, Daniel Moj, Hannah Britz, Thomas Eissing, Thomas Wendl, Thorsten Lehr. PBPK Models for CYP3A4 and P-gp DDI Prediction: A Modeling Network of Rifampicin, Itraconazole, Clarithromycin, Midazolam, Alfentanil, and Digoxin.
CPT: pharmacometrics & systems pharmacology.
2018 10; 7(10):647-659. doi:
10.1002/psp4.12343. [PMID: 30091221] - Carolyn Schifftner, Gery Schulteis, Mark S Wallace. Effect of Intravenous Alfentanil on Nonpainful Thermally Induced Hyperalgesia in Healthy Volunteers.
Journal of clinical pharmacology.
2017 09; 57(9):1207-1214. doi:
10.1002/jcph.911. [PMID: 28464270] - M Roozekrans, E Olofsen, R van der Schrier, M Boom, R Mooren, A Dahan. Doxapram-mediated Increase in Cardiac Output Reduces Opioid Plasma Concentrations: A Pharmacokinetic/Pharmacodynamic-Pharmacokinetic/Pharmacodynamic Modeling Study in Healthy Volunteers.
Clinical pharmacology and therapeutics.
2017 07; 102(1):115-122. doi:
10.1002/cpt.601. [PMID: 28001306] - Mohammad H Abou-Arab, Morten Rostrup, Tom Heier. Dose requirements of alfentanil to eliminate autonomic responses during rapid-sequence induction with thiopental 4 mg/kg and rocuronium 0.6 mg/kg.
Journal of clinical anesthesia.
2016 Dec; 35(?):465-474. doi:
10.1016/j.jclinane.2016.09.026. [PMID: 27871575] - Pegah Zahedi, Saied Saeed Hosseiny Davarani, Hamid Reza Moazami, Saeed Nojavan. Surfactant assisted pulsed two-phase electromembrane extraction followed by GC analysis for quantification of basic drugs in biological samples.
Journal of pharmaceutical and biomedical analysis.
2016 Jan; 117(?):485-91. doi:
10.1016/j.jpba.2015.10.002. [PMID: 26469297] - M H Abou-Arab, J R Feiner, O Spigset, T Heier. Alfentanil during rapid sequence induction with thiopental 4 mg/kg and rocuronium 0.6 mg/kg: tracheal intubation conditions.
Acta anaesthesiologica Scandinavica.
2015 Nov; 59(10):1278-86. doi:
10.1111/aas.12584. [PMID: 26176994] - M Barann, U M Stamer, M Lyutenska, F Stüber, H Bönisch, B Urban. Effects of opioids on human serotonin transporters.
Naunyn-Schmiedeberg's archives of pharmacology.
2015 Jan; 388(1):43-9. doi:
10.1007/s00210-014-1056-3. [PMID: 25332055] - T Schaaf, M Lyutenska, B W Urban, M Wittmann. Direct effects of morphine but not of fentanyl-type opioids on human 5-HT3A receptors in outside-out patch-clamp studies.
European journal of pain (London, England).
2014 Sep; 18(8):1165-72. doi:
10.1002/j.1532-2149.2014.00463.x. [PMID: 24590579] - Guillaume Baneyx, Neil Parrott, Christophe Meille, Athanassios Iliadis, Thierry Lavé. Physiologically based pharmacokinetic modeling of CYP3A4 induction by rifampicin in human: influence of time between substrate and inducer administration.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.
2014 Jun; 56(?):1-15. doi:
10.1016/j.ejps.2014.02.002. [PMID: 24530864] - B H Pypendop, R J Brosnan, C R Majewski-Tiedeken, S D Stanley, J E Ilkiw. Pharmacokinetics of fentanyl, alfentanil, and sufentanil in isoflurane-anesthetized cats.
Journal of veterinary pharmacology and therapeutics.
2014 Feb; 37(1):13-7. doi:
10.1111/jvp.12047. [PMID: 23895731] - Min-Hsien Chiang, Shao-Chun Wu, Chia-Hsun You, Keng-Liang Wu, Yi-Chun Chiu, Chao-Wei Ma, Chin-Wei Kao, Kun-Chen Lin, Kuan-Hung Chen, Peng-Chih Wang, An-Kuo Chou. Target-controlled infusion vs. manually controlled infusion of propofol with alfentanil for bidirectional endoscopy: a randomized controlled trial.
Endoscopy.
2013 Nov; 45(11):907-14. doi:
10.1055/s-0033-1344645. [PMID: 24165817] - N Sigmond, M Baechtold, P M Schumacher, V Hartwich, T W Schnider, M Luginbühl. Pharmacokinetic parameter sets of alfentanil revisited: optimal parameters for use in target controlled infusion and anaesthesia display systems.
British journal of anaesthesia.
2013 Aug; 111(2):197-208. doi:
10.1093/bja/aet049. [PMID: 23512864] - Ali Reza Fakhari, Hadi Tabani, Saeed Nojavan. Miniaturized hollow fibre assisted liquid-phase microextraction and gas chromatography for determination of trace concentration of sufentanil and alfentanil in biological samples.
Drug testing and analysis.
2013 Jul; 5(7):589-95. doi:
10.1002/dta.1387. [PMID: 22786780] - James R Miner, Johanna C Moore, David Plummer, Richard O Gray, Sagar Patel, Jeffrey D Ho. Randomized clinical trial of the effect of supplemental opioids in procedural sedation with propofol on serum catecholamines.
Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.
2013 Apr; 20(4):330-7. doi:
10.1111/acem.12110. [PMID: 23701339] - O Pérus, A Marsot, E Ramain, M Dahman, A Paci, M Raucoules-Aimé, N Simon. Performance of alfentanil target-controlled infusion in normal and morbidly obese female patients.
British journal of anaesthesia.
2012 Oct; 109(4):551-60. doi:
10.1093/bja/aes211. [PMID: 22732112] - Marija Bosilkovska, Bernhard Walder, Marie Besson, Youssef Daali, Jules Desmeules. Analgesics in patients with hepatic impairment: pharmacology and clinical implications.
Drugs.
2012 Aug; 72(12):1645-69. doi:
10.2165/11635500-000000000-00000. [PMID: 22867045] - G Zadoyan, D Rokitta, S Klement, A Dienel, R Hoerr, T Gramatté, U Fuhr. Effect of Ginkgo biloba special extract EGb 761® on human cytochrome P450 activity: a cocktail interaction study in healthy volunteers.
European journal of clinical pharmacology.
2012 May; 68(5):553-60. doi:
10.1007/s00228-011-1174-5. [PMID: 22189672] - Joanne N Michou, Elizabeth A Leece, Jacqueline C Brearley. Comparison of pain on injection during induction of anaesthesia with alfaxalone and two formulations of propofol in dogs.
Veterinary anaesthesia and analgesia.
2012 May; 39(3):275-81. doi:
10.1111/j.1467-2995.2012.00709.x. [PMID: 22414225] - E D Kharasch, D Whittington, D Ensign, C Hoffer, P S Bedynek, S Campbell, K Stubbert, A Crafford, A London, T Kim. Mechanism of efavirenz influence on methadone pharmacokinetics and pharmacodynamics.
Clinical pharmacology and therapeutics.
2012 Apr; 91(4):673-84. doi:
10.1038/clpt.2011.276. [PMID: 22398970] - Maiko Yamauchi-Satomoto, Yushi U Adachi, Tadayoshi Kurita, Koji Morita, Shigehito Sato. Cross-clamping of the descending thoracic aorta leads to the asymmetrical distribution of propofol during cardiopulmonary bypass surgery.
Korean journal of anesthesiology.
2012 Apr; 62(4):327-31. doi:
10.4097/kjae.2012.62.4.327. [PMID: 22558498] - Kuntheavy Ing Lorenzini, Youssef Daali, Pierre Dayer, Jules Desmeules. Pharmacokinetic-pharmacodynamic modelling of opioids in healthy human volunteers. a minireview.
Basic & clinical pharmacology & toxicology.
2012 Mar; 110(3):219-26. doi:
10.1111/j.1742-7843.2011.00814.x. [PMID: 21995512] - Evan D Kharasch, Pamela Sheffels Bedynek, Christine Hoffer, Alysa Walker, Dale Whittington. Lack of indinavir effects on methadone disposition despite inhibition of hepatic and intestinal cytochrome P4503A (CYP3A).
Anesthesiology.
2012 Feb; 116(2):432-47. doi:
10.1097/aln.0b013e3182423478. [PMID: 22273859] - Wan-hua Yang, Hong-bin Gu, Bing Chen, Juan Li, Qiu-wei Fan, Yong-fang Yuan, Xiangdong Wang. Evaluation of SLOG/TCI-III pediatric system on target control infusion of propofol.
Journal of translational medicine.
2011 Nov; 9(?):187. doi:
10.1186/1479-5876-9-187. [PMID: 22044738] - Beena Parikh, Jyotsna Maliwad, Veena R Shah. Preventive analgesia: Effect of small dose of ketamine on morphine requirement after renal surgery.
Journal of anaesthesiology, clinical pharmacology.
2011 Oct; 27(4):485-8. doi:
10.4103/0970-9185.86592. [PMID: 22096281] - Sabina Strano-Rossi, Iván Alvarez, María Jesús Tabernero, Pamela Cabarcos, Purificación Fernández, Ana María Bermejo. Determination of fentanyl, metabolite and analogs in urine by GC/MS.
Journal of applied toxicology : JAT.
2011 Oct; 31(7):649-54. doi:
10.1002/jat.1613. [PMID: 21132842] - C Isles, S Robertson, A Almond, K Donaldson, D Clark. The challenges of renal replacement therapy and renal palliative care in the elderly.
The journal of the Royal College of Physicians of Edinburgh.
2011 Sep; 41(3):238-43. doi:
10.4997/jrcpe.2011.313. [PMID: 21949923] - E D Kharasch, A Francis, A London, K Frey, T Kim, J Blood. Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimal and noninvasive probes for hepatic and first-pass CYP3A induction.
Clinical pharmacology and therapeutics.
2011 Jul; 90(1):100-8. doi:
10.1038/clpt.2011.59. [PMID: 21562488] - Thomas Kim, Amy London, Evan D Kharasch. Simultaneous determination of alfentanil and midazolam in human plasma using liquid chromatography and tandem mass spectrometry.
Journal of pharmaceutical and biomedical analysis.
2011 Jun; 55(3):487-93. doi:
10.1016/j.jpba.2011.01.040. [PMID: 21382685] - Mohammad Saraji, Malihe Khalili Boroujeni, Ali Akbar Hajialiakbari Bidgoli. Comparison of dispersive liquid-liquid microextraction and hollow fiber liquid-liquid-liquid microextraction for the determination of fentanyl, alfentanil, and sufentanil in water and biological fluids by high-performance liquid chromatography.
Analytical and bioanalytical chemistry.
2011 Jun; 400(7):2149-58. doi:
10.1007/s00216-011-4874-x. [PMID: 21442368] - E D Kharasch, S Vangveravong, N Buck, A London, T Kim, J Blood, R H Mach. Concurrent assessment of hepatic and intestinal cytochrome P450 3A activities using deuterated alfentanil.
Clinical pharmacology and therapeutics.
2011 Apr; 89(4):562-70. doi:
10.1038/clpt.2010.313. [PMID: 21346758] - Maria Pieri, Nadia Miraglia, Giuliano Polichetti, Giovanni Tarantino, Antonio Acampora, Domenico Capone. Analytical and pharmacological aspects of therapeutic drug monitoring of mTOR inhibitors.
Current drug metabolism.
2011 Mar; 12(3):253-67. doi:
10.2174/138920011795101868. [PMID: 21342112] - Kyung Yeon Yoo, Cheol Won Jeong, Woong Mo Kim, Hyung Kon Lee, Seongtae Jeong, Seok Jae Kim, Hong Beum Bae, Dong Yun Lim, Sung Su Chung. Cardiovascular and arousal responses to single-lumen endotracheal and double-lumen endobronchial intubation in the normotensive and hypertensive elderly.
Korean journal of anesthesiology.
2011 Feb; 60(2):90-7. doi:
10.4097/kjae.2011.60.2.90. [PMID: 21390163] - Offie P Soldin, Sarah H Chung, Donald R Mattison. Sex differences in drug disposition.
Journal of biomedicine & biotechnology.
2011; 2011(?):187103. doi:
10.1155/2011/187103. [PMID: 21403873] - Hye Rim Jeon, Won Seok Chae, Se Jin Lee, Joon Ho Lee, Sung Hwan Cho, Sang Hyun Kim, Hee Cheol Jin, Jeong Seok Lee, Yong Ik Kim. A comparison of sufentanil and fentanyl for patient-controlled epidural analgesia in arthroplasty.
Korean journal of anesthesiology.
2011 Jan; 60(1):41-6. doi:
10.4097/kjae.2011.60.1.41. [PMID: 21359080] - Agnieszka Bienert, Paweł Wiczling, Czesław Zaba, Zbigniew Zaba, Anna Wolc, Ryszard Marciniak, Edmund Grześkowiak, Krzysztof Kusza. Influence of demographic factors, basic blood test parameters and opioid type on propofol pharmacokinetics and pharmacodynamics in ASA I-III patients.
Arzneimittel-Forschung.
2011; 61(10):545-52. doi:
10.1055/s-0031-1300552. [PMID: 22164962] - S Mousavi, B Levcovich, M Mojtahedzadeh. A systematic review on pharmacokinetic changes in critically ill patients: role of extracorporeal membrane oxygenation.
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences.
2011; 19(5):312-21. doi:
NULL. [PMID: 22615675] - Sarah Cooreman, Christa Deprez, Frank Martens, Jan Van Bocxlaer, Kathleen Croes. A comprehensive LC-MS-based quantitative analysis of fentanyl-like drugs in plasma and urine.
Journal of separation science.
2010 Sep; 33(17-18):2654-62. doi:
10.1002/jssc.201000330. [PMID: 20658494] - Mi Ja Yun, Yoon Hee Kim, Young Kwon Go, Ji Eun Shin, Choon Gun Ryu, Won Kim, Nam Jong Paik, Moon Ku Han, Sang Hwan Do, Woo Suk Jung. Remifentanil attenuates muscle fasciculations by succinylcholine.
Yonsei medical journal.
2010 Jul; 51(4):585-9. doi:
10.3349/ymj.2010.51.4.585. [PMID: 20499427] - Bård E Heradstveit, Anne Berit Guttormsen, Jørund Langørgen, Stig-Morten Hammersborg, Tore Wentzel-Larsen, Rune Fanebust, Elna-Marie Larsson, Jon-Kenneth Heltne. Capillary leakage in post-cardiac arrest survivors during therapeutic hypothermia - a prospective, randomised study.
Scandinavian journal of trauma, resuscitation and emergency medicine.
2010 May; 18(?):29. doi:
10.1186/1757-7241-18-29. [PMID: 20500876] - Yong Ku Han, Cheol Won Jeong, Hyung Gon Lee. Pain reduction on injection of microemulsion propofol via combination of remifentanil and lidocaine.
Korean journal of anesthesiology.
2010 May; 58(5):435-9. doi:
10.4097/kjae.2010.58.5.435. [PMID: 20532050] - David J Duncan, Zhaokang Yang, Philip M Hopkins, Derek S Steele, Simon M Harrison. TNF-alpha and IL-1beta increase Ca2+ leak from the sarcoplasmic reticulum and susceptibility to arrhythmia in rat ventricular myocytes.
Cell calcium.
2010 Apr; 47(4):378-86. doi:
10.1016/j.ceca.2010.02.002. [PMID: 20227109] - So Jin Park, Hye Jin Park, Ju Youn Choi, Hyo Seok Kang, Hong Seok Choi. The influence of age and gender on remifentanil EC(50) for preventing rocuronium induced withdrawal movements.
Korean journal of anesthesiology.
2010 Mar; 58(3):244-8. doi:
10.4097/kjae.2010.58.3.244. [PMID: 20498772] - Kevin D Johnston. The potential for mu-opioid receptor agonists to be anti-emetic in humans: a review of clinical data.
Acta anaesthesiologica Scandinavica.
2010 Feb; 54(2):132-40. doi:
10.1111/j.1399-6576.2009.02115.x. [PMID: 19817719] - S O Mashayekhi, M Ghandforoush-Sattari, D C Buss, P A Routledge, R Dw Hain. Impact of anti-cancer drugs and other determinants on serum protein binding of morphine 6-glucuronide.
Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences.
2010; 18(2):107-13. doi:
. [PMID: 22615603] - S M Lee, G H Kim, J J Lee, J A Kim, S J Choi, G S Kim, H H Jung. Does propofol and alfentanil-induced sedation cause periodic apnoea in chronic renal failure patients?.
International journal of clinical practice.
2010 Jan; 64(1):1-5. doi:
10.1111/j.1742-1241.2007.01443.x. [PMID: 18005040] - Y Ginosar, E M Davidson, Y Meroz, S Blotnick, M Shacham, Y Caraco. Mu-opioid receptor (A118G) single-nucleotide polymorphism affects alfentanil requirements for extracorporeal shock wave lithotripsy: a pharmacokinetic-pharmacodynamic study.
British journal of anaesthesia.
2009 Sep; 103(3):420-7. doi:
10.1093/bja/aep192. [PMID: 19605407] - Gianpaolo Carrafiello, Domenico Laganà, Andrea Ianniello, Federico Fontana, Monica Mangini, Lucia Mocciardini, Emanuela Spanò, Filippo Piacentino, Salvatore Cuffari, Carlo Fugazzola. Plasma-mediated radiofrequency ablation followed by percutaneous cementoplasty under fluoro-CT guidance: a case report.
Cases journal.
2009 Aug; 2(?):8548. doi:
10.4076/1757-1626-2-8548. [PMID: 19918385] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j. [PMID: 19445515] - Evan D Kharasch, Alysa Walker, Dale Whittington, Christine Hoffer, Pamela Sheffels Bedynek. Methadone metabolism and clearance are induced by nelfinavir despite inhibition of cytochrome P4503A (CYP3A) activity.
Drug and alcohol dependence.
2009 May; 101(3):158-68. doi:
10.1016/j.drugalcdep.2008.12.009. [PMID: 19232844] - Evan D Kharasch, Christine Hoffer, Dale Whittington, Alysa Walker, Pamela Sheffels Bedynek. Methadone pharmacokinetics are independent of cytochrome P4503A (CYP3A) activity and gastrointestinal drug transport: insights from methadone interactions with ritonavir/indinavir.
Anesthesiology.
2009 Mar; 110(3):660-72. doi:
10.1097/aln.0b013e3181986a9a. [PMID: 19225389] - Ricardo Antonio G Barbosa, Silvia Regina C Jorge Santos, Paul F White, Valéria A Pereira, Carlos R Silva Filho, Luiz M S Malbouisson, Maria José C Carmona. Effects of cardiopulmonary bypass on propofol pharmacokinetics and bispectral index during coronary surgery.
Clinics (Sao Paulo, Brazil).
2009; 64(3):215-21. doi:
10.1590/s1807-59322009000300012. [PMID: 19330248] - Matthias Haenggi, Heidi Ypparila-Wolters, Kathrin Hauser, Claudio Caviezel, Jukka Takala, Ilkka Korhonen, Stephan M Jakob. Intra- and inter-individual variation of BIS-index and Entropy during controlled sedation with midazolam/remifentanil and dexmedetomidine/remifentanil in healthy volunteers: an interventional study.
Critical care (London, England).
2009; 13(1):R20. doi:
10.1186/cc7723. [PMID: 19228415] - E D Kharasch, P S Bedynek, A Walker, D Whittington, C Hoffer. Mechanism of ritonavir changes in methadone pharmacokinetics and pharmacodynamics: II. Ritonavir effects on CYP3A and P-glycoprotein activities.
Clinical pharmacology and therapeutics.
2008 Oct; 84(4):506-12. doi:
10.1038/clpt.2008.102. [PMID: 19238656] - Maria Wittmann, Thomas Schaaf, Ineke Peters, Stefan Wirz, Bernd W Urban, Martin Barann. The effects of fentanyl-like opioids and hydromorphone on human 5-HT3A receptors.
Anesthesia and analgesia.
2008 Jul; 107(1):107-12. doi:
10.1213/ane.0b013e31817342c2. [PMID: 18635474] - R Scott Obach, Franco Lombardo, Nigel J Waters. Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Drug metabolism and disposition: the biological fate of chemicals.
2008 Jul; 36(7):1385-405. doi:
10.1124/dmd.108.020479. [PMID: 18426954] - Evan D Kharasch, Darain Mitchell, Rebecka Coles, Roberto Blanco. Rapid clinical induction of hepatic cytochrome P4502B6 activity by ritonavir.
Antimicrobial agents and chemotherapy.
2008 May; 52(5):1663-9. doi:
10.1128/aac.01600-07. [PMID: 18285471] - A Vega Vega, V de Blas Gómez, R Guerreiro González, F J Gallo Rolanía. [Single center experience with Siemens Lithostar Modularis for treatment of 1500 solitiary urinary stones].
Actas urologicas espanolas.
2008 May; 32(5):546-51. doi:
10.1016/s0210-4806(08)73881-6. [PMID: 18605007] - B G Oertel, C Preibisch, T Wallenhorst, T Hummel, G Geisslinger, H Lanfermann, J Lötsch. Differential opioid action on sensory and affective cerebral pain processing.
Clinical pharmacology and therapeutics.
2008 Apr; 83(4):577-88. doi:
10.1038/sj.clpt.6100441. [PMID: 18030306] - Martin White, Gavin N C Kenny, Stefan Schraag. Use of target controlled infusion to derive age and gender covariates for propofol clearance.
Clinical pharmacokinetics.
2008; 47(2):119-27. doi:
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Clinical pharmacokinetics.
2008; 47(11):743-52. doi:
10.2165/00003088-200847110-00005. [PMID: 18840029] - Richard S Bourne, Gary H Mills, Cosetta Minelli. Melatonin therapy to improve nocturnal sleep in critically ill patients: encouraging results from a small randomised controlled trial.
Critical care (London, England).
2008; 12(2):R52. doi:
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Clinical pharmacology and therapeutics.
2007 Oct; 82(4):410-26. doi:
10.1038/sj.clpt.6100237. [PMID: 17554244] - J Cory Kalvass, Emily R Olson, Michael P Cassidy, Dana E Selley, Gary M Pollack. Pharmacokinetics and pharmacodynamics of seven opioids in P-glycoprotein-competent mice: assessment of unbound brain EC50,u and correlation of in vitro, preclinical, and clinical data.
The Journal of pharmacology and experimental therapeutics.
2007 Oct; 323(1):346-55. doi:
10.1124/jpet.107.119560. [PMID: 17646430] - John Heijmans, Erik Fransen, Wim Buurman, Jos Maessen, Paul Roekaerts. Comparison of the modulatory effects of four different fast-track anesthetic techniques on the inflammatory response to cardiac surgery with cardiopulmonary bypass.
Journal of cardiothoracic and vascular anesthesia.
2007 Aug; 21(4):512-8. doi:
10.1053/j.jvca.2007.02.008. [PMID: 17678776] - Michaela Vossen, Michael Sevestre, Christoph Niederalt, In-Jin Jang, Stefan Willmann, Andrea N Edginton. Dynamically simulating the interaction of midazolam and the CYP3A4 inhibitor itraconazole using individual coupled whole-body physiologically-based pharmacokinetic (WB-PBPK) models.
Theoretical biology & medical modelling.
2007 Mar; 4(?):13. doi:
10.1186/1742-4682-4-13. [PMID: 17386084] - Shu-Ming Wang, Mamatha Punjala, Dana Weiss, Kevin Anderson, Zeev N Kain. Acupuncture as an adjunct for sedation during lithotripsy.
Journal of alternative and complementary medicine (New York, N.Y.).
2007 Mar; 13(2):241-6. doi:
10.1089/acm.2006.6262. [PMID: 17388767] - D J Duncan, P M Hopkins, S M Harrison. Negative inotropic effects of tumour necrosis factor-alpha and interleukin-1beta are ameliorated by alfentanil in rat ventricular myocytes.
British journal of pharmacology.
2007 Mar; 150(6):720-6. doi:
10.1038/sj.bjp.0707147. [PMID: 17279089] - J Cory Kalvass, Emily R Olson, Gary M Pollack. Pharmacokinetics and pharmacodynamics of alfentanil in P-glycoprotein-competent and P-glycoprotein-deficient mice: P-glycoprotein efflux alters alfentanil brain disposition and antinociception.
Drug metabolism and disposition: the biological fate of chemicals.
2007 Mar; 35(3):455-9. doi:
10.1124/dmd.106.011445. [PMID: 17178769] - Zbigniew Zaba, Agnieszka Bienert, Leon Drobnik, Stanislaw Dyderski, Krzysztof Kusza. Spectral frequency index monitoring during propofol-remifentanil and propofol-alfentanil total intravenous anaesthesia.
CNS drugs.
2007; 21(2):165-71. doi:
10.2165/00023210-200721020-00006. [PMID: 17284097] - Oliver Kimberger, Syed Z Ali, Monica Markstaller, Sandra Zmoos, Rolf Lauber, Corinne Hunkeler, Andrea Kurz. Meperidine and skin surface warming additively reduce the shivering threshold: a volunteer study.
Critical care (London, England).
2007; 11(1):R29. doi:
10.1186/cc5709. [PMID: 17316456] - Nariné Baririan, Luc Van Obbergh, Jean-Pierre Desager, Roger K Verbeeck, Pierre Wallemacq, Peter Starkel, Yves Horsmans. Alfentanil-induced miosis as a surrogate measure of alfentanil pharmacokinetics in patients with mild and moderate liver cirrhosis.
Clinical pharmacokinetics.
2007; 46(3):261-70. doi:
10.2165/00003088-200746030-00006. [PMID: 17328584] - Károly Gombocz, Agnes Beledi, Nasri Alotti, Gábor Kecskés, Valéria Gábor, Lajos Bogár, Tamás Koszegi, János Garai. Influence of dextran-70 on systemic inflammatory response and myocardial ischaemia-reperfusion following cardiac operations.
Critical care (London, England).
2007; 11(4):R87. doi:
10.1186/cc6095. [PMID: 17697359] - Fliss E M Murtagh, Mee-Onn Chai, Paul Donohoe, Polly M Edmonds, Irene J Higginson. The use of opioid analgesia in end-stage renal disease patients managed without dialysis: recommendations for practice.
Journal of pain & palliative care pharmacotherapy.
2007; 21(2):5-16. doi:
NULL. [PMID: 17844723] - Agnieszka Skulska, Maria Kała, Piotr Adamowicz, Ewa Chudzikiewicz, Wojciech Lechowicz. [Determination of fentanyl, atropine and scopolamine in biological material using LC-MS/APCI methods].
Przeglad lekarski.
2007; 64(4-5):263-7. doi:
NULL. [PMID: 17724883] - Teijo I Saari, Kari Laine, Kari Leino, Mika Valtonen, Pertti J Neuvonen, Klaus T Olkkola. Voriconazole, but not terbinafine, markedly reduces alfentanil clearance and prolongs its half-life.
Clinical pharmacology and therapeutics.
2006 Nov; 80(5):502-8. doi:
10.1016/j.clpt.2006.07.008. [PMID: 17112806] - Kim Davenport, Andrea Minervini, Stephen Keoghane, John Parkin, Francis X Keeley, Anthony G Timoney. Does rate matter? The results of a randomized controlled trial of 60 versus 120 shocks per minute for shock wave lithotripsy of renal calculi.
The Journal of urology.
2006 Nov; 176(5):2055-8; discussion 2058. doi:
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Anesthesiology.
2006 Sep; 105(3):462-70. doi:
10.1097/00000542-200609000-00008. [PMID: 16931977] - Koshi Makita, Seiji Ishikawa. [Remifentanil].
Masui. The Japanese journal of anesthesiology.
2006 Jul; 55(7):817-25. doi:
NULL. [PMID: 16856541] - Chi-Liang Mao, Keith D Zientek, Patrick T Colahan, Mei-Yueh Kuo, Chi-Ho Liu, Kuo-Ming Lee, Chi-Chung Chou. Development of an enzyme-linked immunosorbent assay for fentanyl and applications of fentanyl antibody-coated nanoparticles for sample preparation.
Journal of pharmaceutical and biomedical analysis.
2006 Jun; 41(4):1332-41. doi:
10.1016/j.jpba.2006.03.009. [PMID: 16621415] - K Schmieder, F Möller, M Engelhardt, M Scholz, W Schregel, A Christmann, A Harders. Dynamic cerebral autoregulation in patients with ruptured and unruptured aneurysms after induction of general anesthesia.
Zentralblatt fur Neurochirurgie.
2006 May; 67(2):81-7. doi:
10.1055/s-2006-933374. [PMID: 16673240] - Sven Björkman. Prediction of cytochrome p450-mediated hepatic drug clearance in neonates, infants and children : how accurate are available scaling methods?.
Clinical pharmacokinetics.
2006; 45(1):1-11. doi:
10.2165/00003088-200645010-00001. [PMID: 16430308] - Andrea N Edginton, Walter Schmitt, Stefan Willmann. Development and evaluation of a generic physiologically based pharmacokinetic model for children.
Clinical pharmacokinetics.
2006; 45(10):1013-34. doi:
10.2165/00003088-200645100-00005. [PMID: 16984214] - Narine Baririan, Yves Horsmans, Jean-Pierre Desager, Roger Verbeeck, Roger Vanbinst, Pierre Wallemacq, Luc Van Obbergh. Alfentanil-induced miosis clearance as a liver CYP3A4 and 3A5 activity measure in healthy volunteers: improvement of experimental conditions.
Journal of clinical pharmacology.
2005 Dec; 45(12):1434-41. doi:
10.1177/0091270005282629. [PMID: 16291719] - Harshvardhan N Chaobal, Evan D Kharasch. Single-point sampling for assessment of constitutive, induced, and inhibited cytochrome P450 3A activity with alfentanil or midazolam.
Clinical pharmacology and therapeutics.
2005 Nov; 78(5):529-39. doi:
10.1016/j.clpt.2005.08.004. [PMID: 16321619] - P Kintz, M Villain, V Dumestre, V Cirimele. Evidence of addiction by anesthesiologists as documented by hair analysis.
Forensic science international.
2005 Oct; 153(1):81-4. doi:
10.1016/j.forsciint.2005.04.033. [PMID: 15967611] - Evan D Kharasch, Alysa Walker, Christine Hoffer, Pamela Sheffels. Sensitivity of intravenous and oral alfentanil and pupillary miosis as minimally invasive and noninvasive probes for hepatic and first-pass CYP3A activity.
Journal of clinical pharmacology.
2005 Oct; 45(10):1187-97. doi:
10.1177/0091270005280077. [PMID: 16172184] - M Cicek, A Koroglu, S Demirbilek, H Teksan, M O Ersoy. Comparison of propofol-alfentanil and propofol-remifentanil anaesthesia in percutaneous nephrolithotripsy.
European journal of anaesthesiology.
2005 Sep; 22(9):683-8. doi:
10.1017/s0265021505001134. [PMID: 16163915] - Helène Schulte, Alf Sollevi, Märta Segerdahl. Dose-dependent effects of morphine on experimentally induced cutaneous pain in healthy volunteers.
Pain.
2005 Aug; 116(3):366-374. doi:
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Revista brasileira de anestesiologia.
2005 Jun; 55(3):336-42. doi:
10.1590/s0034-70942005000300010. [PMID: 19471838] - E J Murphy. Acute pain management pharmacology for the patient with concurrent renal or hepatic disease.
Anaesthesia and intensive care.
2005 Jun; 33(3):311-22. doi:
10.1177/0310057x0503300306. [PMID: 15973913] - Sylvie Passot, Frédérique Servin, Jean Pascal, Françoise Charret, Christian Auboyer, Serge Molliex. A comparison of target- and manually controlled infusion propofol and etomidate/desflurane anesthesia in elderly patients undergoing hip fracture surgery.
Anesthesia and analgesia.
2005 May; 100(5):1338-1342. doi:
10.1213/01.ane.0000149542.04833.55. [PMID: 15845680] - Jörn Lötsch. Pharmacokinetic-pharmacodynamic modeling of opioids.
Journal of pain and symptom management.
2005 May; 29(5 Suppl):S90-103. doi:
10.1016/j.jpainsymman.2005.01.012. [PMID: 15907650] - Theresa Mariero Klees, Pamela Sheffels, Ola Dale, Evan D Kharasch. Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes.
Drug metabolism and disposition: the biological fate of chemicals.
2005 Mar; 33(3):303-11. doi:
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