Alfentanil (BioDeep_00000001883)
Secondary id: BioDeep_00000398415
human metabolite blood metabolite
代谢物信息卡片
N-{1-[2-(4-ethyl-5-oxo-4,5-dihydro-1H-1,2,3,4-tetrazol-1-yl)ethyl]-4-(methoxymethyl)piperidin-4-yl}-N-phenylpropanamide
化学式: C21H32N6O3 (416.2536)
中文名称: 阿芬太尼
谱图信息:
最多检出来源 Homo sapiens(blood) 16.91%
分子结构信息
SMILES: CCC(=O)N(C1=CC=CC=C1)C2(CCN(CC2)CCN3C(=O)N(N=N3)CC)COC
InChI: InChI=1S/C21H32N6O3/c1-4-19(28)27(18-9-7-6-8-10-18)21(17-30-3)11-13-24(14-12-21)15-16-26-20(29)25(5-2)22-23-26/h6-10H,4-5,11-17H2,1-3H3
描述信息
A short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients. [PubChem]
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D009294 - Narcotics
N - Nervous system > N01 - Anesthetics > N01A - Anesthetics, general > N01AH - Opioid anesthetics
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
C78272 - Agent Affecting Nervous System > C67413 - Opioid Receptor Agonist
D002491 - Central Nervous System Agents > D000700 - Analgesics
同义名列表
14 个代谢物同义名
N-{1-[2-(4-ethyl-5-oxo-4,5-dihydro-1H-1,2,3,4-tetrazol-1-yl)ethyl]-4-(methoxymethyl)piperidin-4-yl}-N-phenylpropanamide; N-(1-(2-(4-Ethyl-5-oxo-2-tetrazolin-1-yl)ethyl)-4-(methoxymethyl)-4-piperidyl)propionanilide; Janssen brand OF alfentanil hydrochloride; Esteve brand OF alfentanil hydrochloride; ICI brand OF alfentanil hydrochloride; alfentanil hydrochloride; Alfentanilum; Alfentanyl; ALFENTANIL; Fanaxal; Limifen; Alfenta; Rapifen; Alfentanil
数据库引用编号
17 个数据库交叉引用编号
- ChEBI: CHEBI:2569
- KEGG: C08005
- KEGGdrug: D07122
- PubChem: 51263
- HMDB: HMDB0014940
- Metlin: METLIN844
- DrugBank: DB00802
- ChEMBL: CHEMBL634
- Wikipedia: Alfentanil
- MeSH: Alfentanil
- chemspider: 46451
- CAS: 71195-58-9
- PMhub: MS000001381
- PubChem: 10205
- NIKKAJI: J330.279B
- RefMet: Alfentanil
- KNApSAcK: 2569
分类词条
相关代谢途径
Reactome(0)
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PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Mark S Wallace. Effect of Pregabalin on the Median Effective Plasma Concentration of Intravenous Alfentanil in Capsaicin-Induced Pain.
Pain medicine (Malden, Mass.).
2021 Dec; 22(12):3072-3079. doi:
10.1093/pm/pnab222. [PMID: 34329455] - Jean Jung, Allan Kolodziej, Elise Pape, Michael Bisch, Lucie Javot, Valérie Gibaja, Jean-Yves Jouzeau, Julien Scala-Bertola, Nicolas Gambier. Multiplex detection of 14 fentanyl analogues and U-47700 in biological samples: Application to a panel of French hospitalized patients.
Forensic science international.
2020 Dec; 317(?):110437. doi:
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Journal of veterinary pharmacology and therapeutics.
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Xenobiotica; the fate of foreign compounds in biological systems.
2020 Aug; 50(8):875-884. doi:
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Clinical pharmacokinetics.
2020 04; 59(4):501-518. doi:
10.1007/s40262-019-00827-4. [PMID: 31587145] - Jing-Yang Liou, Mei-Yung Tsou, Shinju Obara, Lu Yu, Chien-Kun Ting. Plasma concentration based response surface model predict better than effect-site concentration based model for wake-up time during gastrointestinal endoscopy sedation.
Journal of the Formosan Medical Association = Taiwan yi zhi.
2019 Jan; 118(1 Pt 2):291-298. doi:
10.1016/j.jfma.2018.05.007. [PMID: 29803320] - Nina Hanke, Sebastian Frechen, Daniel Moj, Hannah Britz, Thomas Eissing, Thomas Wendl, Thorsten Lehr. PBPK Models for CYP3A4 and P-gp DDI Prediction: A Modeling Network of Rifampicin, Itraconazole, Clarithromycin, Midazolam, Alfentanil, and Digoxin.
CPT: pharmacometrics & systems pharmacology.
2018 10; 7(10):647-659. doi:
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2017 09; 57(9):1207-1214. doi:
10.1002/jcph.911. [PMID: 28464270] - M Roozekrans, E Olofsen, R van der Schrier, M Boom, R Mooren, A Dahan. Doxapram-mediated Increase in Cardiac Output Reduces Opioid Plasma Concentrations: A Pharmacokinetic/Pharmacodynamic-Pharmacokinetic/Pharmacodynamic Modeling Study in Healthy Volunteers.
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2017 07; 102(1):115-122. doi:
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2008 May; 52(5):1663-9. doi:
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Actas urologicas espanolas.
2008 May; 32(5):546-51. doi:
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Clinical pharmacology and therapeutics.
2008 Apr; 83(4):577-88. doi:
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Clinical pharmacokinetics.
2008; 47(2):119-27. doi:
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Clinical pharmacokinetics.
2008; 47(11):743-52. doi:
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Critical care (London, England).
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Clinical pharmacology and therapeutics.
2007 Oct; 82(4):410-26. doi:
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The Journal of pharmacology and experimental therapeutics.
2007 Oct; 323(1):346-55. doi:
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Journal of cardiothoracic and vascular anesthesia.
2007 Aug; 21(4):512-8. doi:
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Theoretical biology & medical modelling.
2007 Mar; 4(?):13. doi:
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Journal of alternative and complementary medicine (New York, N.Y.).
2007 Mar; 13(2):241-6. doi:
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British journal of pharmacology.
2007 Mar; 150(6):720-6. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2007 Mar; 35(3):455-9. doi:
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CNS drugs.
2007; 21(2):165-71. doi:
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Critical care (London, England).
2007; 11(1):R29. doi:
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Clinical pharmacokinetics.
2007; 46(3):261-70. doi:
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Critical care (London, England).
2007; 11(4):R87. doi:
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Journal of pain & palliative care pharmacotherapy.
2007; 21(2):5-16. doi:
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Przeglad lekarski.
2007; 64(4-5):263-7. doi:
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Clinical pharmacology and therapeutics.
2006 Nov; 80(5):502-8. doi:
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The Journal of urology.
2006 Nov; 176(5):2055-8; discussion 2058. doi:
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Anesthesiology.
2006 Sep; 105(3):462-70. doi:
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Masui. The Japanese journal of anesthesiology.
2006 Jul; 55(7):817-25. doi:
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Journal of pharmaceutical and biomedical analysis.
2006 Jun; 41(4):1332-41. doi:
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Zentralblatt fur Neurochirurgie.
2006 May; 67(2):81-7. doi:
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Clinical pharmacokinetics.
2006; 45(1):1-11. doi:
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Clinical pharmacokinetics.
2006; 45(10):1013-34. doi:
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Journal of clinical pharmacology.
2005 Dec; 45(12):1434-41. doi:
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Clinical pharmacology and therapeutics.
2005 Nov; 78(5):529-39. doi:
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Forensic science international.
2005 Oct; 153(1):81-4. doi:
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Journal of clinical pharmacology.
2005 Oct; 45(10):1187-97. doi:
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European journal of anaesthesiology.
2005 Sep; 22(9):683-8. doi:
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Pain.
2005 Aug; 116(3):366-374. doi:
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Revista brasileira de anestesiologia.
2005 Jun; 55(3):336-42. doi:
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Anaesthesia and intensive care.
2005 Jun; 33(3):311-22. doi:
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Anesthesia and analgesia.
2005 May; 100(5):1338-1342. doi:
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Journal of pain and symptom management.
2005 May; 29(5 Suppl):S90-103. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2005 Mar; 33(3):303-11. doi:
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