1,2,3-Trichloropropane (BioDeep_00000009884)

 

Secondary id: BioDeep_00000858403

human metabolite blood metabolite


代谢物信息卡片


1,2,3-TRICHLOROPROPANE

化学式: C3H5Cl3 (145.9457)
中文名称: 1,2,3-三氯丙烷标准溶液, 1,2,3-三氯丙烷
谱图信息: 最多检出来源 () 0%

分子结构信息

SMILES: C(C(CCl)Cl)Cl
InChI: InChI=1S/C3H5Cl3/c4-1-3(6)2-5/h3H,1-2H2



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 4 APP, CYP1A1, CYP2E1, UBD
Peripheral membrane protein 4 CYP1A1, CYP1B1, CYP2E1, SORD
Endoplasmic reticulum membrane 4 CYP1A1, CYP1A2, CYP1B1, CYP2E1
Mitochondrion membrane 1 SORD
Nucleus 4 APP, MAX, PDE7A, UBD
cytosol 5 APP, GPT, PDE7A, SORD, UBD
dendrite 2 APP, MAX
mitochondrial membrane 1 SORD
nucleoplasm 3 MAX, RFX1, UBD
RNA polymerase II transcription regulator complex 1 MAX
Cell membrane 2 APP, SLC38A5
Cell projection, growth cone 1 APP
Multi-pass membrane protein 1 SLC38A5
Synapse 1 APP
cell surface 1 APP
ciliary rootlet 1 APP
dendritic shaft 1 APP
Golgi apparatus 1 APP
growth cone 1 APP
mitochondrial inner membrane 3 APP, CYP1A1, CYP2E1
neuromuscular junction 1 APP
smooth endoplasmic reticulum 1 APP
synaptic vesicle 1 APP
endosome 1 APP
plasma membrane 2 APP, SLC38A5
presynaptic active zone 1 APP
Membrane 4 APP, CYP1B1, SLC38A5, SORD
axon 1 APP
extracellular exosome 3 APP, GPT, SORD
endoplasmic reticulum 1 APP
extracellular space 2 APP, SORD
perinuclear region of cytoplasm 2 APP, PDE7A
mitochondrion 2 CYP1A1, CYP1B1
intracellular membrane-bounded organelle 5 CYP1A1, CYP1A2, CYP1B1, CYP2E1, RFX1
Microsome membrane 4 CYP1A1, CYP1A2, CYP1B1, CYP2E1
Single-pass type I membrane protein 1 APP
Secreted 1 APP
extracellular region 1 APP
motile cilium 1 SORD
dendritic spine 1 APP
perikaryon 1 APP
cytoplasmic vesicle 1 APP
Early endosome 1 APP
Membrane, clathrin-coated pit 1 APP
apical part of cell 1 APP
cell-cell junction 1 APP
clathrin-coated pit 1 APP
COPII-coated ER to Golgi transport vesicle 1 APP
Golgi-associated vesicle 1 APP
recycling endosome 1 APP
spindle midzone 1 APP
vesicle 1 APP
Mitochondrion inner membrane 2 CYP1A1, CYP2E1
Membrane raft 1 APP
receptor complex 1 APP
chromatin 2 MAX, RFX1
Cell projection, cilium, flagellum 1 SORD
fibrillar center 1 UBD
endosome lumen 1 APP
Cell projection, dendrite 1 MAX
trans-Golgi network membrane 1 APP
Golgi lumen 1 APP
endoplasmic reticulum lumen 1 APP
MLL1 complex 1 MAX
platelet alpha granule lumen 1 APP
aggresome 1 UBD
nuclear envelope lumen 1 APP
protein-DNA complex 1 MAX
Myc-Max complex 1 MAX
[C83]: Endoplasmic reticulum 1 APP
[C99]: Early endosome 1 APP
[Soluble APP-beta]: Secreted 1 APP
[Amyloid-beta protein 40]: Cell surface 1 APP
[Amyloid-beta protein 42]: Cell surface 1 APP
[Gamma-secretase C-terminal fragment 59]: Nucleus 1 APP
Mad-Max complex 1 MAX
[Isoform PDE7A1]: Cytoplasm, cytosol 1 PDE7A
[Isoform PDE7A2]: Cytoplasm 1 PDE7A


文献列表

  • Hiroshi Matsumoto, Fumiyo Saito, Masahiro Takeyoshi. Investigation of the early-response genes in chemical-induced renal carcinogenicity for the prediction of chemical carcinogenicity in rats. The Journal of toxicological sciences. 2017; 42(2):175-181. doi: 10.2131/jts.42.175. [PMID: 28321044]
  • Masayuki Kimura, Sayaka Mizukami, Yousuke Watanabe, Yasuko Hasegawa-Baba, Nobuhiko Onda, Toshinori Yoshida, Makoto Shibutani. Disruption of spindle checkpoint function in rats following 28 days of repeated administration of renal carcinogens. The Journal of toxicological sciences. 2016 Feb; 41(1):91-104. doi: 10.2131/jts.41.91. [PMID: 26763396]
  • P Liu, Y-G Liang, Q-Y Meng, C-G Zhang, H-C Wang, X-G Zhang, G Li, Z-Y Liu, Y-Z He. Successful therapy with hemoperfusion and plasma exchange in acute 1,2,3-trichloropropane poisoning. Human & experimental toxicology. 2012 May; 31(5):523-7. doi: 10.1177/0960327111426586. [PMID: 22045893]
  • Hui Han. Acute 1,2,3-trichloropane poisoning: a case report and literature review. Basic & clinical pharmacology & toxicology. 2010 Dec; 107(6):988-90. doi: 10.1111/j.1742-7843.2010.00624.x. [PMID: 20825388]
  • NULL. Reproductive toxicology. 1,2,3-Trichloropropane. Environmental health perspectives. 1997 Feb; 105 Suppl 1(?):361-2. doi: NULL. [PMID: 9114362]
  • D K La, R Schoonhoven, N Ito, J A Swenberg. The effects of exposure route on DNA adduct formation and cellular proliferation by 1,2,3-trichloropropane. Toxicology and applied pharmacology. 1996 Sep; 140(1):108-14. doi: 10.1006/taap.1996.0203. [PMID: 8806876]
  • R D Irwin, J K Haseman, S L Eustis. 1,2,3-Trichloropropane: a multisite carcinogen in rats and mice. Fundamental and applied toxicology : official journal of the Society of Toxicology. 1995 May; 25(2):241-52. doi: 10.1006/faat.1995.1060. [PMID: 7665008]
  • . NTP Toxicology and Carcinogenesis of 1,2,3-Trichloropropane (CAS No. 96-18-4) in F344/N Rats and B6C3F1 Mice (Gavage Studies). National Toxicology Program technical report series. 1993 Aug; 384(?):1-348. doi: . [PMID: 12692652]
  • B A Merrick, M Robinson, L W Condie. Cardiopathic effect of 1,2,3-trichloropropane after subacute and subchronic exposure in rats. Journal of applied toxicology : JAT. 1991 Jun; 11(3):179-87. doi: 10.1002/jat.2550110305. [PMID: 1918791]
  • N A Mahmood, D Overstreet, L T Burka. Comparative disposition and metabolism of 1,2,3-trichloropropane in rats and mice. Drug metabolism and disposition: the biological fate of chemicals. 1991 Mar; 19(2):411-8. doi: NULL. [PMID: 1676646]
  • F R Johannsen, G J Levinskas, G M Rusch, J B Terrill, R E Schroeder. Evaluation of the subchronic and reproductive effects of a series of chlorinated propanes in the rat. I. Toxicity of 1,2,3-trichloropropane. Journal of toxicology and environmental health. 1988; 25(3):299-315. doi: 10.1080/15287398809531211. [PMID: 3184199]
  • D C Villeneuve, I Chu, V E Secours, M G Coté, G L Plaa, V E Valli. Results of a 90-day toxicity study on 1,2,3- and 1,1,2-trichloropropane administered via the drinking water. The Science of the total environment. 1985 Dec; 47(?):421-6. doi: 10.1016/0048-9697(85)90346-8. [PMID: 4089609]
  • R F Volp, I G Sipes, C Falcoz, D E Carter, J F Gross. Disposition of 1,2,3-trichloropropane in the Fischer 344 rat: conventional and physiological pharmacokinetics. Toxicology and applied pharmacology. 1984 Aug; 75(1):8-17. doi: 10.1016/0041-008x(84)90070-x. [PMID: 6431641]