Succinylsulfathiazole (BioDeep_00000008843)
Secondary id: BioDeep_00000015137
human metabolite blood metabolite
代谢物信息卡片
化学式: C13H13N3O5S2 (355.0297)
中文名称: 琥珀磺胺噻唑
谱图信息:
最多检出来源 Homo sapiens(plant) 0.8%
分子结构信息
SMILES: c1cc(ccc1NC(=O)CCC(=O)O)S(=O)(=O)Nc1nccs1
InChI: InChI=1S/C13H13N3O5S2/c17-11(5-6-12(18)19)15-9-1-3-10(4-2-9)23(20,21)16-13-14-7-8-22-13/h1-4,7-8H,5-6H2,(H,14,16)(H,15,17)(H,18,19)
描述信息
Same as: D07060
同义名列表
12 个代谢物同义名
3-({4-[(1,3-thiazol-2-yl)sulphamoyl]phenyl}carbamoyl)propanoic acid; 3-({4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}carbamoyl)propanoic acid; 3-({4-[(1,3-thiazol-2-yl)sulphamoyl]phenyl}carbamoyl)propanoate; 3-({4-[(1,3-thiazol-2-yl)sulfamoyl]phenyl}carbamoyl)propanoate; 4-(2-Thiazolylsulfamoyl)succinanilic acid; Succinylsulfathiazole monohydrate; Succinyl sulfathiazole; Succinylsulphathiazole; succinylsulfathiazole; Sulfasuccithiazole; Succinyl sulfathiazole; 4'-(2-Thiazolylsulfamoyl)succinanilic acid
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:9309
- KEGG: C11745
- PubChem: 5315
- HMDB: HMDB0258548
- Metlin: METLIN44631
- Wikipedia: Succinylsulfathiazole
- chemspider: 5124
- CAS: 116-43-8
- PMhub: MS000022545
- PubChem: 13910
- NIKKAJI: J5.280I
- RefMet: Succinylsulfathiazole
- KNApSAcK: 9309
- DrugBank: DB13580
分类词条
相关代谢途径
Reactome()
BioCyc()
PlantCyc()
代谢反应
个相关的代谢反应过程信息。
Reactome()
BioCyc()
WikiPathways()
Plant Reactome()
INOH()
PlantCyc()
COVID-19 Disease Map()
PathBank()
PharmGKB()
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Safa Beydoun, Ali M Fardous, Michael M Saruna, Ali G Beydoun, Johnathan A Sorge, Hongzhi Ma, Ghada Aoun, Archana Unnikrishnan, Diane C Cabelof, Ahmad R Heydari. Succinylsulfathiazole modulates the mTOR signaling pathway in the liver of c57BL/6 mice via a folate independent mechanism.
Experimental gerontology.
2021 07; 150(?):111387. doi:
10.1016/j.exger.2021.111387. [PMID: 33957263] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Wansu Qiu, Aarthi R Gobinath, Yanhua Wen, Jehannine Austin, Liisa A M Galea. Folic acid, but not folate, regulates different stages of neurogenesis in the ventral hippocampus of adult female rats.
Journal of neuroendocrinology.
2019 10; 31(10):e12787. doi:
10.1111/jne.12787. [PMID: 31478270] - Bogdan Wlodarczyk, Ofer Spiegelstein, Denise Hill, X Chris Le, Richard H Finnell. Arsenic urinary speciation in Mthfr deficient mice injected with sodium arsenate.
Toxicology letters.
2012 Dec; 215(3):214-8. doi:
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Drug metabolism and disposition: the biological fate of chemicals.
2012 Dec; 40(12):2332-41. doi:
10.1124/dmd.112.047068. [PMID: 22961681] - Christian Thoma, Timothy J Green, Lynnette R Ferguson. Citrus pectin and oligofructose improve folate status and lower serum total homocysteine in rats.
International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition.
2003 Nov; 73(6):403-9. doi:
10.1024/0300-9831.73.6.403. [PMID: 14743543] - G M Semchuk, O B Allen, D L O'Connor. Folate bioavailability from milk-containing diets is affected by altered intestinal biosynthesis of folate in rats.
The Journal of nutrition.
1994 Jul; 124(7):1118-25. doi:
10.1093/jn/124.7.1118. [PMID: 8027864] - M S Dar, P L Morselli, E R Bowman. The enzymatic systems involved in the mammalian metabolism of methylamine.
General pharmacology.
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10.1016/0306-3623(85)90142-9. [PMID: 2867948] - W W Wells, R Quan-MA, C R Cook, S C Anderson. Lactose diets and cholesterol metabolism. II. Effect of dietary cholesterol, succinylsulfathiazole and mode of feeding on atherogenesis in the rabbit.
The Journal of nutrition.
1962 01; 76(?):41-7. doi:
10.1093/jn/76.1.41. [PMID: 14006052] - W E CORNATZER, D G GALLO. Effects of dietary aureomycin and sulfasuxidine on phosphorylation in the liver of rats.
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