Thiamylal (BioDeep_00000006616)

 

Secondary id: BioDeep_00001868259

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


Dihydro-5-(1-methylbutyl)-5-(2-propenyl)-2-thioxo-4,6(1H,5H)-pyrimidinedione

化学式: C12H18N2O2S (254.1089)
中文名称: 巴比妥, 硫胺素
谱图信息: 最多检出来源 Homo sapiens(blood) 40%

分子结构信息

SMILES: C=CCC1(C(C)CCC)C(=O)NC(=S)NC1=O
InChI: InChI=1S/C12H18N2O2S/c1-4-6-8(3)12(7-5-2)9(15)13-11(17)14-10(12)16/h5,8H,2,4,6-7H2,1,3H3,(H2,13,14,15,16,17)

描述信息

Thiamylal is only found in individuals that have used or taken this drug. It is a barbiturate that is administered intravenously for the production of complete anesthesia of short duration, for the induction of general anesthesia, or for inducing a hypnotic state. (From Martindale, The Extra Pharmacopoeia, 30th ed, p919)Thiamylal binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D006993 - Hypnotics and Sedatives
D002491 - Central Nervous System Agents > D002492 - Central Nervous System Depressants > D000777 - Anesthetics
C78272 - Agent Affecting Nervous System > C29756 - Sedative and Hypnotic > C67084 - Barbiturate
D018377 - Neurotransmitter Agents > D018682 - GABA Agents > D018757 - GABA Modulators
C78272 - Agent Affecting Nervous System > C245 - Anesthetic Agent

同义名列表

16 个代谢物同义名

Dihydro-5-(1-methylbutyl)-5-(2-propenyl)-2-thioxo-4,6(1H,5H)-pyrimidinedione; 5-(pentan-2-yl)-5-(prop-2-en-1-yl)-2-sulfanylidene-1,3-diazinane-4,6-dione; 5-Allyl-5-(1-methylbutyl)-2-thioxodihydro-4,6(1H,5H)-pyrimidinedione; 5-Allyl-5-(1-methylbutyl)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione; 5-Allyl-5-(1-methylbutyl)-2-thiobarbituric acid; 5-Allyl-5-(1-methylbutyl)-2-thiobarbitic acid; 5-Allyl-5-(1-methylbutyl)-2-thiobarbitate; Parke davis brand OF thiamylal sodium; Thioquinalbarbitone; Sodium, thiamylal; Thiamylal sodium; Thioseconal; thiamylal; Surital; Thiamylal; Thiamylal



数据库引用编号

17 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 12 ADRA1A, ALB, ARNT, AXIN2, CA1, CYP2C9, CYP2E1, CYP3A4, DLK1, DMD, IKBKG, SDF4
Peripheral membrane protein 2 CYP2E1, DMD
Endoplasmic reticulum membrane 3 CYP2C9, CYP2E1, CYP3A4
Nucleus 6 ADRA1A, ALB, ARNT, AXIN2, DMD, IKBKG
cytosol 9 ADRA1A, ALB, AXIN2, CA1, DMD, IKBKG, MB, PRKCQ, SST
nuclear body 1 ARNT
centrosome 2 ALB, AXIN2
nucleoplasm 3 ADRA1A, ARNT, IKBKG
RNA polymerase II transcription regulator complex 1 ARNT
Cell membrane 2 ADRA1A, SDF4
Cytoplasmic side 1 DMD
Multi-pass membrane protein 5 ADRA1A, CACNA1I, KCNA3, KCNJ11, KCNJ8
Synapse 1 DMD
cell surface 1 DMD
glutamatergic synapse 3 KCNA3, KCNJ11, KCNJ8
Golgi apparatus 2 ALB, SDF4
mitochondrial inner membrane 1 CYP2E1
neuronal cell body 2 KCNJ11, SST
presynaptic membrane 2 KCNA3, KCNJ11
sarcolemma 2 DMD, KCNJ8
acrosomal vesicle 1 KCNJ11
endosome 1 KCNJ11
plasma membrane 11 ADRA1A, AXIN2, CACNA1I, CYP2C9, DMD, KCNA3, KCNJ11, KCNJ8, KNG1, PRKCQ, SDF4
Membrane 8 CACNA1I, CYP3A4, DLK1, DMD, KCNA3, KCNJ11, KCNJ8, SDF4
axon 1 KCNA3
caveola 1 ADRA1A
extracellular exosome 5 ALB, CA1, KNG1, MB, SDF4
endoplasmic reticulum 2 ALB, SDF4
extracellular space 4 ALB, DLK1, KNG1, SST
perinuclear region of cytoplasm 1 KCNA3
intercalated disc 1 KCNJ11
protein-containing complex 3 ALB, DMD, IKBKG
intracellular membrane-bounded organelle 4 ADRA1A, CYP2C9, CYP2E1, CYP3A4
Microsome membrane 3 CYP2C9, CYP2E1, CYP3A4
filopodium 1 DMD
Secreted 2 ALB, SST
extracellular region 3 ALB, KNG1, SST
Single-pass membrane protein 1 DLK1
anchoring junction 1 ALB
transcription regulator complex 1 ARNT
centriolar satellite 1 PRKCQ
Nucleus membrane 1 ADRA1A
nuclear membrane 1 ADRA1A
T-tubule 1 KCNJ11
Z disc 1 DMD
beta-catenin destruction complex 1 AXIN2
sarcoplasm 1 MB
postsynaptic membrane 2 DMD, KCNA3
presynaptic active zone membrane 1 KCNJ8
Cell membrane, sarcolemma 1 DMD
Mitochondrion inner membrane 1 CYP2E1
Membrane raft 2 DMD, KCNA3
Cytoplasm, cytoskeleton 1 DMD
axolemma 1 KCNJ11
GABA-ergic synapse 1 SST
myofibril 1 KCNJ8
collagen-containing extracellular matrix 1 KNG1
Nucleus outer membrane 1 DMD
nuclear outer membrane 1 DMD
Postsynaptic cell membrane 1 DMD
Late endosome 1 SDF4
ciliary basal body 1 ALB
chromatin 1 ARNT
mitotic spindle 1 IKBKG
cytoskeleton 1 DMD
centriole 1 ALB
[Isoform 5]: Cytoplasm 1 SDF4
Secreted, extracellular space 1 KNG1
spindle pole 2 ALB, IKBKG
blood microparticle 2 ALB, KNG1
[Isoform 2]: Cell membrane 1 KCNA3
nuclear envelope 1 KCNJ11
Membrane, caveola 1 ADRA1A
monoatomic ion channel complex 2 KCNJ11, KCNJ8
aryl hydrocarbon receptor complex 1 ARNT
cell body fiber 1 KCNJ11
inward rectifying potassium channel 2 KCNJ11, KCNJ8
ubiquitin ligase complex 1 IKBKG
filopodium membrane 1 DMD
voltage-gated potassium channel complex 2 KCNA3, KCNJ8
Golgi apparatus lumen 1 SDF4
Golgi lumen 1 SDF4
endoplasmic reticulum lumen 2 ALB, KNG1
platelet alpha granule lumen 2 ALB, KNG1
voltage-gated calcium channel complex 1 CACNA1I
immunological synapse 1 PRKCQ
neuronal dense core vesicle 1 SST
aggresome 1 PRKCQ
Single-pass type IV membrane protein 1 DMD
calyx of Held 1 KCNA3
IkappaB kinase complex 1 IKBKG
costamere 1 DMD
[Isoform 1]: Cell membrane 1 KCNA3
dystrophin-associated glycoprotein complex 1 DMD
cell-substrate junction 1 DMD
potassium ion-transporting ATPase complex 1 KCNJ8
bleb 1 SDF4
Cytoplasm, sarcoplasm 1 MB
neuron projection terminus 1 DMD
syntrophin complex 1 DMD
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3
nuclear aryl hydrocarbon receptor complex 1 ARNT
ciliary transition fiber 1 ALB
[Isoform 1]: Golgi apparatus lumen 1 SDF4
organelle 1 DMD
plasma membrane bounded cell projection 1 DMD


文献列表

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