Desogestrel (BioDeep_00000006555)

 

Secondary id: BioDeep_00000637527

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


(1S,2R,10S,11S,14R,15S)-15-ethyl-14-ethynyl-17-methylidenetetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-14-ol

化学式: C22H30O (310.2297)
中文名称: 去氧孕烯
谱图信息: 最多检出来源 Homo sapiens(blood) 12.15%

分子结构信息

SMILES: C#CC1(O)CCC2C3CCC4=CCCCC4C3C(=C)CC21CC
InChI: InChI=1S/C22H30O/c1-4-21-14-15(3)20-17-9-7-6-8-16(17)10-11-18(20)19(21)12-13-22(21,23)5-2/h2,8,17-20,23H,3-4,6-7,9-14H2,1H3/t17-,18-,19-,20+,21-,22-/m0/s1

描述信息

Desogestrel is only found in individuals that have used or taken this drug. It is a synthetic progestational hormone used often as the progestogenic component of combined oral contraceptive agents. [PubChem]Binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like desogestrel will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge.
G - Genito urinary system and sex hormones > G03 - Sex hormones and modulators of the genital system > G03A - Hormonal contraceptives for systemic use > G03AC - Progestogens
D006730 - Hormones, Hormone Substitutes, and Hormone Antagonists > D006728 - Hormones > D011372 - Progestins
C147908 - Hormone Therapy Agent > C548 - Therapeutic Hormone > C1636 - Therapeutic Steroid Hormone
D012102 - Reproductive Control Agents > D003270 - Contraceptive Agents

同义名列表

15 个代谢物同义名

(1S,2R,10S,11S,14R,15S)-15-ethyl-14-ethynyl-17-methylidenetetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-6-en-14-ol; alpha-Pregn-4-en-20-yn-17-ol, 13-ethyl-11-methylene-18,19-dinor-17; 13 Ethyl 11 methylene 18,19 dinor 17 alpha pregn 4 en 20 yn 17 ol; 13-Ethyl-11-methylene-18,19-dinor-17 alpha-pregn-4-en-20-yn-17-ol; 13-Ethyl-11-methylene-18,19-dinor-17alpha-pregn-4-en-20-yn-17-ol; 13-Ethyl-11-methylene-18,19-dinor-17a-pregn-4-en-20-yn-17-ol; 13-ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17alpha-ol; 13-Ethyl-11-methylene-18,19-dinor-17α-pregn-4-en-20-yn-17-ol; Organon brand OF desogestrel; Desogestrelum; Desogestrel; Cerazette; mircette; Marvelon; Desogestrel



数据库引用编号

20 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ALB, APOB, AR, DSG1, PGR, PRL
Endosome membrane 1 APOB
Endoplasmic reticulum membrane 2 APOB, PROS1
Nucleus 5 ALB, AR, DSG1, PGR, PRL
cytosol 7 ALB, APOA1, APOA2, APOB, AR, DSG1, PGR
centrosome 1 ALB
nucleoplasm 3 AR, PGR, PRL
RNA polymerase II transcription regulator complex 1 PRL
Cell membrane 1 DSG1
cell surface 1 PLG
glutamatergic synapse 1 PLG
Golgi apparatus 1 ALB
Golgi membrane 2 INS, PROS1
lysosomal membrane 1 CP
neuronal cell body 1 APOB
smooth endoplasmic reticulum 1 APOB
plasma membrane 11 APOA1, APOB, AR, CP, DSG1, F2, F7, PGR, PLG, PROS1, SERPINC1
Membrane 1 AR
apical plasma membrane 1 DSG1
extracellular exosome 12 ALB, APOA1, APOA2, APOB, CP, F2, PLG, PROS1, SERPINA6, SERPINA7, SERPINC1, SHBG
endoplasmic reticulum 2 ALB, PROS1
extracellular space 16 ALB, APOA1, APOA2, APOB, CP, F2, F7, GNRH1, INS, LPA, PLG, PRL, PROS1, SERPINA6, SERPINA7, SERPINC1
lysosomal lumen 1 APOB
Schaffer collateral - CA1 synapse 1 PLG
protein-containing complex 2 ALB, AR
intracellular membrane-bounded organelle 1 APOB
Single-pass type I membrane protein 1 DSG1
Secreted 12 ALB, APOA1, APOA2, APOB, CP, F2, F7, INS, PLG, PRL, PROS1, SHBG
extracellular region 17 ALB, APOA1, APOA2, APOB, CP, F2, F7, GNRH1, INS, LPA, PLG, PRL, PROS1, SERPINA6, SERPINA7, SERPINC1, SHBG
cytoplasmic side of plasma membrane 1 DSG1
mitochondrial outer membrane 1 PGR
anchoring junction 1 ALB
external side of plasma membrane 1 PLG
Extracellular vesicle 1 APOA1
chylomicron 3 APOA1, APOA2, APOB
high-density lipoprotein particle 2 APOA1, APOA2
low-density lipoprotein particle 2 APOA1, APOB
very-low-density lipoprotein particle 3 APOA1, APOA2, APOB
cytoplasmic vesicle 1 APOA1
Early endosome 3 APOA1, APOA2, APOB
vesicle 1 F7
collagen-containing extracellular matrix 5 APOA1, F2, F7, PLG, SERPINC1
lateral plasma membrane 1 DSG1
nuclear speck 1 AR
ciliary basal body 1 ALB
chromatin 3 AR, PGR, PRL
centriole 1 ALB
Secreted, extracellular space 1 SERPINC1
spindle pole 1 ALB
blood microparticle 8 ALB, APOA1, APOA2, CP, F2, PLG, PROS1, SERPINC1
endosome lumen 3 APOB, INS, PRL
Lipid droplet 1 APOB
Cornified envelope 1 DSG1
secretory granule lumen 2 APOA1, INS
Golgi lumen 4 F2, F7, INS, PROS1
endoplasmic reticulum lumen 9 ALB, APOA1, APOA2, APOB, CP, F2, F7, INS, SERPINC1
platelet alpha granule lumen 3 ALB, PLG, PROS1
endocytic vesicle 1 APOA1
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
endoplasmic reticulum exit site 1 APOB
clathrin-coated endocytic vesicle membrane 1 APOB
ficolin-1-rich granule membrane 1 DSG1
Cell junction, desmosome 1 DSG1
desmosome 1 DSG1
spherical high-density lipoprotein particle 2 APOA1, APOA2
endocytic vesicle lumen 2 APOA1, APOB
chylomicron remnant 1 APOB
intermediate-density lipoprotein particle 1 APOB
mature chylomicron 1 APOB
[Isoform 4]: Mitochondrion outer membrane 1 PGR
plasma lipoprotein particle 1 LPA
serine-type peptidase complex 1 F7
ciliary transition fiber 1 ALB


文献列表

  • Jingwen Gan, Shi-Yang Zhu, Xiao Ma, Xue-Song Ding, Yan Deng, Yanfang Wang, Ai-Jun Sun. The effect of Ding-kun-dan comparing with Marvelon on primary dysmenorrhea: A prospective, double-blind, multicenter, randomized controlled trial. Journal of ethnopharmacology. 2023 Jul; ?(?):116975. doi: 10.1016/j.jep.2023.116975. [PMID: 37517569]
  • Shiyang Zhu, Xiao Ma, Xuesong Ding, Jingwen Gan, Yan Deng, Yanfang Wang, Aijun Sun. Comparative evaluation of low-level light therapy and ethinyl estradiol and desogestrel combined oral contraceptive for clinical efficacy and regulation of serum biochemical parameters in primary dysmenorrhoea: a prospective randomised multicentre trial. Lasers in medical science. 2022 Jun; 37(4):2239-2248. doi: 10.1007/s10103-021-03490-z. [PMID: 35028764]
  • Farhad Kafi Mallak, Helena Kopp Kallner. Migration of a subdermal contraceptive implant into a subsegmental pulmonary artery and etonogestrel serum concentration over time - a case report. The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception. 2022 Jun; 27(3):261-264. doi: 10.1080/13625187.2022.2036977. [PMID: 35174737]
  • Aaron Lazorwitz, Jeanelle Sheeder, Stephanie Teal. Variability in repeat serum etonogestrel concentrations among contraceptive implant users during the steady-release pharmacokinetic period. Contraception. 2022 04; 108(?):65-68. doi: 10.1016/j.contraception.2021.12.008. [PMID: 34973207]
  • Aaron Lazorwitz, Morgan Pena, Jeanelle Sheeder, Stephanie Teal. Effect of Topiramate on Serum Etonogestrel Concentrations Among Contraceptive Implant Users. Obstetrics and gynecology. 2022 04; 139(4):579-587. doi: 10.1097/aog.0000000000004697. [PMID: 35594123]
  • Le-Kai Nie, Hong-Li Zou, Lei Cheng, Pei-Hai Zhang. Subcutaneous etonogestrel implant combined with endometrial ablation for the treatment of adenomyosis: two case reports. The journal of obstetrics and gynaecology research. 2022 Jan; 48(1):262-265. doi: 10.1111/jog.15084. [PMID: 34713941]
  • Regis Kreitchmann, Alice Stek, Brookie M Best, Edmund Capparelli, JiaJia Wang, David Shapiro, Nahida Chakhtoura, Mark Mirochnick, Ahizechukwu C Eke. Interactions between etonogestrel-releasing contraceptive implant and 3 antiretroviral regimens. Contraception. 2022 01; 105(?):67-74. doi: 10.1016/j.contraception.2021.08.006. [PMID: 34407424]
  • Santiago Palacios, Enrico Colli, Pedro A Regidor. Metabolic and laboratory effects of a progestin-only pill containing drospirenone 4 mg in comparison to desogestrel 75 µg: a double-blind, double-dummy, prospective, randomised study. The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception. 2021 Dec; 26(6):454-461. doi: 10.1080/13625187.2021.1957094. [PMID: 34348526]
  • Aaron Lazorwitz, Christina L Aquilante, Jonathan A Shortt, Jeanelle Sheeder, Stephanie Teal, Christopher R Gignoux. Applicability of ancestral genotyping in pharmacogenomic research with hormonal contraception. Clinical and translational science. 2021 09; 14(5):1713-1718. doi: 10.1111/cts.13014. [PMID: 33650294]
  • Lekai Nie, Hongli Zou, Xiaotian Ma, Lei Cheng, Jun Jiao, Fenghua Wang, Weifeng Liang, Peihai Zhang. A clinical observational study on the efficacy of subcutaneous etonogestrel implants for adenomyosis in 20 patients. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2021 Aug; 37(8):735-739. doi: 10.1080/09513590.2021.1922886. [PMID: 34160336]
  • Aaron Lazorwitz, Jeanelle Sheeder, Stephanie Teal. An exploratory study on the association of lifestyle factors with serum etonogestrel concentrations among contraceptive implant users. The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception. 2021 Aug; 26(4):323-325. doi: 10.1080/13625187.2021.1887475. [PMID: 33596152]
  • Mariane Massaini Barbieri, Thuany Bento Herculano, Amanda Dantas Silva, Luis Bahamondes, Cassia Raquel Teatin Juliato, Fernanda Garanhani Surita. Acceptability of ENG-releasing subdermal implants among postpartum Brazilian young women during the COVID-19 pandemic. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. 2021 Jul; 154(1):106-112. doi: 10.1002/ijgo.13663. [PMID: 33656758]
  • Alida M Gertz, Ian J Bishop, Boikhutso Simon, Kwana Lechiile, Opelo Badubi, Aamirah Mussa, Carolyn L Westhoff, Chelsea Morroni. Comparison of plasma etonogestrel concentrations sampled from the contralateral-to-implant and ipsilateral-to-implant arms of contraceptive implant users. Contraception. 2020 12; 102(6):403-405. doi: 10.1016/j.contraception.2020.08.011. [PMID: 32858051]
  • Cesare Battaglia, Bruno Battaglia, Paolo Casadio, Roberta Rizzo, Paolo G Artini. Metformin metabolic and vascular effects in normal weight hyperinsulinemic polycystic ovary syndrome patients treated with contraceptive vaginal ring. A pilot study. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2020 Dec; 36(12):1062-1069. doi: 10.1080/09513590.2020.1770213. [PMID: 32544018]
  • Ian J Bishop, Alida M Gertz, Boikhutso Simon, Leabaneng Tawe, Kwana Lechiile, Serena Liu, Nicholas Teodoro, Aamirah Mussa, Ava Avalos, Sifelani Malima, Tshego Maotwe, Lesego Mokganya, Carolyn L Westhoff, Chelsea Morroni. Etonogestrel concentrations among contraceptive implant users in Botswana using and not using dolutegravir-based antiretroviral therapy. Contraception. 2020 09; 102(3):174-179. doi: 10.1016/j.contraception.2020.04.019. [PMID: 32387328]
  • Aaron Lazorwitz, Rebecca Seale, Anne Davis, Maryam Guiahi. A pilot study on the effect of isotretinoin on serum etonogestrel concentrations in contraceptive implant users. Contraception. 2020 07; 102(1):58-60. doi: 10.1016/j.contraception.2020.04.011. [PMID: 32325076]
  • Meilin He, Guozhong Yang, Xiaoyu Zhao, Suohui Zhang, Yunhua Gao. Intradermal Implantable PLGA Microneedles for Etonogestrel Sustained Release. Journal of pharmaceutical sciences. 2020 06; 109(6):1958-1966. doi: 10.1016/j.xphs.2020.02.009. [PMID: 32084376]
  • Deborah Margatho, Nelsilene Mota Carvalho, Luis Bahamondes. Endometriosis-associated pain scores and biomarkers in users of the etonogestrel-releasing subdermal implant or the 52-mg levonorgestrel-releasing intrauterine system for up to 24 months. The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception. 2020 Apr; 25(2):133-140. doi: 10.1080/13625187.2020.1725461. [PMID: 32069126]
  • David W Haas, Yoninah S Cramer, Catherine Godfrey, Susan L Rosenkranz, Francesca Aweeka, Baiba Berzins, Robert Coombs, Kristine Coughlin, Laura E Moran, David Gingrich, Carmen D Zorrilla, Paxton Baker, Susan E Cohn, Kimberly K Scarsi. Pharmacogenetic interactions between antiretroviral drugs and vaginally administered hormonal contraceptives. Pharmacogenetics and genomics. 2020 04; 30(3):45-53. doi: 10.1097/fpc.0000000000000396. [PMID: 32106141]
  • Lisa B Haddad, Alison Swaims-Kohlmeier, C Christina Mehta, Richard E Haaland, Nakita L Brown, Anandi N Sheth, Hsin Chien, Kehmia Titanji, Sharon L Achilles, Davis Lupo, Clyde E Hart, Igho Ofotokun. Impact of etonogestrel implant use on T-cell and cytokine profiles in the female genital tract and blood. PloS one. 2020; 15(3):e0230473. doi: 10.1371/journal.pone.0230473. [PMID: 32214321]
  • Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein. Molecular pharmacology. 2019 11; 96(5):629-640. doi: 10.1124/mol.119.115964. [PMID: 31515284]
  • Rena C Patel, Randy M Stalter, Katherine K Thomas, Bani Tamraz, Steven W Blue, David W Erikson, Christina J Kim, Edward J Kelly, Kavita Nanda, Athena P Kourtis, Jairam R Lingappa, Nelly Mugo, Jared M Baeten, Kimberly K Scarsi. A pharmacokinetic and pharmacogenetic evaluation of contraceptive implants and antiretroviral therapy among women in Kenya and Uganda. AIDS (London, England). 2019 11; 33(13):1995-2004. doi: 10.1097/qad.0000000000002308. [PMID: 31306173]
  • Francisca Martínez, Jorge Rodriguez-Purata, Elisabet Clua, Sandra Garcia, Buenaventura Coroleu, Nikolaos Polyzos. Ovarian response in oocyte donation cycles under LH suppression with GnRH antagonist or desogestrel progestin: retrospective and comparative study. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology. 2019 Oct; 35(10):884-889. doi: 10.1080/09513590.2019.1604662. [PMID: 31081407]
  • Aaron Lazorwitz, Christina L Aquilante, Eva Dindinger, Margaret Harrison, Jeanelle Sheeder, Stephanie Teal. Relationship Between Etonogestrel Concentrations and Bleeding Patterns in Contraceptive Implant Users. Obstetrics and gynecology. 2019 10; 134(4):807-813. doi: 10.1097/aog.0000000000003452. [PMID: 31503152]
  • Kimberly K Scarsi, Yoninah S Cramer, Susan L Rosenkranz, Francesca Aweeka, Baiba Berzins, Robert W Coombs, Kristine Coughlin, Laura E Moran, Carmen D Zorrilla, Victor Akelo, Mariam Aziz, Ruth K Friedman, David Gingrich, Shobha Swaminathan, Catherine Godfrey, Susan E Cohn. Antiretroviral therapy and vaginally administered contraceptive hormones: a three-arm, pharmacokinetic study. The lancet. HIV. 2019 09; 6(9):e601-e612. doi: 10.1016/s2352-3018(19)30155-9. [PMID: 31498109]
  • Aaron Lazorwitz, Christina L Aquilante, Jeanelle Sheeder, Maryam Guiahi, Stephanie Teal. Relationship between patient characteristics and serum etonogestrel concentrations in contraceptive implant users. Contraception. 2019 07; 100(1):37-41. doi: 10.1016/j.contraception.2019.03.045. [PMID: 30980827]
  • Amihai Rottenstreich, Ram Elazary, Uriel Elchalal, Gabriel Levin. Re: Plasma concentrations of etonogestrel in obese women using oral desogestrel before and after Roux-en-Y gastric bypass surgery: a pharmacokinetic study. BJOG : an international journal of obstetrics and gynaecology. 2019 04; 126(5):676-677. doi: 10.1111/1471-0528.15556. [PMID: 30461162]
  • Charlotte Ginstman, Jan Brynhildsen. Authors' reply re: Plasma concentrations of etonogestrel in obese women using oral desogestrel before and after Roux-en-Y gastric bypass surgery: a pharmacokinetic study. BJOG : an international journal of obstetrics and gynaecology. 2019 04; 126(5):677. doi: 10.1111/1471-0528.15557. [PMID: 30461174]
  • Aaron Lazorwitz, Christina L Aquilante, Kris Oreschak, Jeanelle Sheeder, Maryam Guiahi, Stephanie Teal. Influence of Genetic Variants on Steady-State Etonogestrel Concentrations Among Contraceptive Implant Users. Obstetrics and gynecology. 2019 04; 133(4):783-794. doi: 10.1097/aog.0000000000003189. [PMID: 30870275]
  • C Ginstman, J Frisk, B Carlsson, A Ärlemalm, S Hägg, J Brynhildsen. Plasma concentrations of etonogestrel in women using oral desogestrel before and after Roux-en-Y gastric bypass surgery: a pharmacokinetic study. BJOG : an international journal of obstetrics and gynaecology. 2019 Mar; 126(4):486-492. doi: 10.1111/1471-0528.15511. [PMID: 30347490]
  • Lyndsey R Buckner, Erma Z Drobnis, Molly S Augustine, Lynette K Rogers, Jill Akers, Patricia D Mott, Thomas J Hope, Alison J Quayle, Danny J Schust. Cervical and systemic concentrations of long acting hormonal contraceptive (LARC) progestins depend on delivery method: Implications for the study of HIV transmission. PloS one. 2019; 14(5):e0214152. doi: 10.1371/journal.pone.0214152. [PMID: 31095572]
  • Deborah Margatho, Nelsilene Mota Carvalho, Larissa Eloy, Luis Bahamondes. Assessment of biomarkers in women with endometriosis-associated pain using the ENG contraceptive implant or the 52 mg LNG-IUS: a non-inferiority randomised clinical trial. The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception. 2018 Oct; 23(5):344-350. doi: 10.1080/13625187.2018.1531117. [PMID: 30372645]
  • Rachel E Zigler, Tessa Madden, Caitlin Ashby, Leping Wan, Colleen McNicholas. Ulipristal Acetate for Unscheduled Bleeding in Etonogestrel Implant Users: A Randomized Controlled Trial. Obstetrics and gynecology. 2018 10; 132(4):888-894. doi: 10.1097/aog.0000000000002810. [PMID: 30130351]
  • Joe-Elie Salem, Pauline Dureau, Anne Bachelot, Marine Germain, Pascal Voiriot, Bruno Lebourgeois, David-Alexandre Trégouët, Jean-Sébastien Hulot, Christian Funck-Brentano. Association of Oral Contraceptives With Drug-Induced QT Interval Prolongation in Healthy Nonmenopausal Women. JAMA cardiology. 2018 09; 3(9):877-882. doi: 10.1001/jamacardio.2018.2251. [PMID: 30073300]
  • Jianbo Wu, Yuxiu Huang, Lihong Chen, Jifen Hu, Yilu Zou. Treatment of Adenomyosis with Subcutaneous Etonogestrel Implants: A Clinical Observational Study in 17 Patients. Medical science monitor : international medical journal of experimental and clinical research. 2018 Sep; 24(?):6085-6092. doi: 10.12659/msm.908979. [PMID: 30171680]
  • Wataru Isono, Osamu Wada-Hiraike, Yumiko Kawamura, Tomoyuki Fujii, Yutaka Osuga, Hiroki Kurihara. Administration of Oral Contraceptives Could Alleviate Age-Related Fertility Decline Possibly by Preventing Ovarian Damage in a Mouse Model. Reproductive sciences (Thousand Oaks, Calif.). 2018 09; 25(9):1413-1423. doi: 10.1177/1933719117746758. [PMID: 29237349]
  • Jun Zhang, Mi Su, Liangzhi Xu, Zhilan Yang, Weiyao Yin, Ying Nie, Xiaoyong Qiao, Ran Cheng, Yaxian Ma. [Efficacy and metabolic safety of long-term treatment with ethinyl oestradiol/cyproterone and desogestrel/ethinyl oestradiol tablets in women with polycystic ovary syndrome]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University. 2018 Jul; 38(8):917-922. doi: 10.3969/j.issn.1673-4254.2018.08.03. [PMID: 30187872]
  • Sneha G Nair, Daxesh P Patel, Frank J Gonzalez, Bhargav M Patel, Puran Singhal, Darshan V Chaudhary. Simultaneous determination of etonogestrel and ethinyl estradiol in human plasma by UPLC-MS/MS and its pharmacokinetic study. Biomedical chromatography : BMC. 2018 May; 32(5):e4165. doi: 10.1002/bmc.4165. [PMID: 29228469]
  • Meilin He, Guozhong Yang, Suohui Zhang, Xiaoyu Zhao, Yunhua Gao. Dissolving Microneedles Loaded With Etonogestrel Microcrystal Particles for Intradermal Sustained Delivery. Journal of pharmaceutical sciences. 2018 04; 107(4):1037-1045. doi: 10.1016/j.xphs.2017.11.013. [PMID: 29175412]
  • Andreas J T Pedersen, Tore Bjerregaard Stage, Dorte Glintborg, Marianne Andersen, Mette Marie Hougaard Christensen. The Pharmacogenetics of Metformin in Women with Polycystic Ovary Syndrome: A Randomized Trial. Basic & clinical pharmacology & toxicology. 2018 Feb; 122(2):239-244. doi: 10.1111/bcpt.12874. [PMID: 28834135]
  • Feng Xu, Cuifang Liu, Xiaobo Huang. Oral contraceptives caused venous sinus thrombosis complicated with cerebral artery infarction and secondary epileptic seizures: A case report and literature review. Medicine. 2017 Dec; 96(51):e9383. doi: 10.1097/md.0000000000009383. [PMID: 29390539]
  • Jaime Algorta, Maria Diaz, Raquel de Benito, Marc Lefebvre, Eric Sicard, Milton Furtado, Pedro Antonio Regidor, Celestino Ronchi. Pharmacokinetic bioequivalence, safety and acceptability of Ornibel®, a new polymer composition contraceptive vaginal ring (etonogestrel/ethinylestradiol 11.00/3.474 mg) compared with Nuvaring® (etonogestrel/ethinylestradiol 11.7/2.7 mg). The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception. 2017 Dec; 22(6):429-438. doi: 10.1080/13625187.2017.1413179. [PMID: 29336615]
  • Aaron Lazorwitz, Anne Davis, Maryke Swartz, Maryam Guiahi. The effect of carbamazepine on etonogestrel concentrations in contraceptive implant users. Contraception. 2017 Jun; 95(6):571-577. doi: 10.1016/j.contraception.2017.03.004. [PMID: 28288788]
  • Colleen McNicholas, Erin Swor, Leping Wan, Jeffrey F Peipert. Prolonged use of the etonogestrel implant and levonorgestrel intrauterine device: 2 years beyond Food and Drug Administration-approved duration. American journal of obstetrics and gynecology. 2017 06; 216(6):586.e1-586.e6. doi: 10.1016/j.ajog.2017.01.036. [PMID: 28147241]
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