Phenindione (BioDeep_00000006543)

 

Secondary id: BioDeep_00000408797

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


2-phenyl-2,3-dihydro-1H-indene-1,3-dione

化学式: C15H10O2 (222.06807600000002)
中文名称: 苯茚二酮
谱图信息: 最多检出来源 Viridiplantae(plant) 72.73%

分子结构信息

SMILES: C1=CC=C(C=C1)C2C(=O)C3=CC=CC=C3C2=O
InChI: InChI=1S/C15H10O2/c16-14-11-8-4-5-9-12(11)15(17)13(14)10-6-2-1-3-7-10/h1-9,13H

描述信息

Phenindione is only found in individuals that have used or taken this drug. It is an indandione that has been used as an anticoagulant. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234)Phenindione inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins, this limits the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulant proteins. The synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Depression of three of the four vitamin K-dependent coagulation factors (factors II, VII, and X) results in decreased prothrombin levels and a decrease in the amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots.
B - Blood and blood forming organs > B01 - Antithrombotic agents > B01A - Antithrombotic agents > B01AA - Vitamin k antagonists
C78275 - Agent Affecting Blood or Body Fluid > C263 - Anticoagulant Agent
D006401 - Hematologic Agents > D000925 - Anticoagulants

同义名列表

19 个代谢物同义名

2-phenyl-2,3-dihydro-1H-indene-1,3-dione; Merck lipha santé brand OF phenindione; Goldshield brand OF phenindione; 2-Phenyl-1,3-diketohydrindene; 2-Phenyl-1,3(2H)-indenedione; Boots brand OF phenindione; 2-Phenyl-1,3-indandione; 2 Phenyl 1,3 indandione; Phenylindanedione; Phenindionum; phenindione; Fenindiona; Phenyline; Pindione; Dindevan; Fenilin; Hedulin; indon; PID



数据库引用编号

18 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

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  • Hongfang Li, Shuang Liu, Baolei Dong, Chenglong Li, Huijuan Yang, Xiya Zhang, Kai Wen, Xuezhi Yu, Wenbo Yu, Jianzhong Shen, Jiancheng Li, Zhanhui Wang. Production of a specific monoclonal antibody and a sensitive immunoassay for the detection of diphacinone in biological samples. Analytical and bioanalytical chemistry. 2019 Oct; 411(25):6755-6765. doi: 10.1007/s00216-019-02051-2. [PMID: 31388716]
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