Phenindione (BioDeep_00000006543)
Secondary id: BioDeep_00000408797
human metabolite blood metabolite Chemicals and Drugs
代谢物信息卡片
2-phenyl-2,3-dihydro-1H-indene-1,3-dione
化学式: C15H10O2 (222.0681)
中文名称: 苯茚二酮
谱图信息:
最多检出来源 Homo sapiens(plant) 5.02%
分子结构信息
SMILES: C1=CC=C(C=C1)C2C(=O)C3=CC=CC=C3C2=O
InChI: InChI=1S/C15H10O2/c16-14-11-8-4-5-9-12(11)15(17)13(14)10-6-2-1-3-7-10/h1-9,13H
描述信息
Phenindione is only found in individuals that have used or taken this drug. It is an indandione that has been used as an anticoagulant. Phenindione has actions similar to warfarin, but it is now rarely employed because of its higher incidence of severe adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p234)Phenindione inhibits vitamin K reductase, resulting in depletion of the reduced form of vitamin K (vitamin KH2). As vitamin K is a cofactor for the carboxylation of glutamate residues on the N-terminal regions of vitamin K-dependent proteins, this limits the gamma-carboxylation and subsequent activation of the vitamin K-dependent coagulant proteins. The synthesis of vitamin K-dependent coagulation factors II, VII, IX, and X and anticoagulant proteins C and S is inhibited. Depression of three of the four vitamin K-dependent coagulation factors (factors II, VII, and X) results in decreased prothrombin levels and a decrease in the amount of thrombin generated and bound to fibrin. This reduces the thrombogenicity of clots.
B - Blood and blood forming organs > B01 - Antithrombotic agents > B01A - Antithrombotic agents > B01AA - Vitamin k antagonists
C78275 - Agent Affecting Blood or Body Fluid > C263 - Anticoagulant Agent
D006401 - Hematologic Agents > D000925 - Anticoagulants
同义名列表
20 个代谢物同义名
2-phenyl-2,3-dihydro-1H-indene-1,3-dione; Merck lipha santé brand OF phenindione; Goldshield brand OF phenindione; 2-Phenyl-1,3-diketohydrindene; 2-Phenyl-1,3(2H)-indenedione; Boots brand OF phenindione; 2-Phenyl-1,3-indandione; 2 Phenyl 1,3 indandione; Phenylindanedione; Phenindionum; phenindione; Fenindiona; Phenyline; Pindione; Dindevan; Fenilin; Hedulin; indon; PID; Phenindione
数据库引用编号
19 个数据库交叉引用编号
- ChEBI: CHEBI:8066
- KEGG: C07584
- KEGGdrug: D92057
- KEGGdrug: D08354
- PubChem: 4760
- HMDB: HMDB0014641
- Metlin: METLIN1813
- DrugBank: DB00498
- ChEMBL: CHEMBL711
- Wikipedia: Phenindione
- MeSH: Phenindione
- chemspider: 4596
- CAS: 83-12-5
- PMhub: MS000019595
- PubChem: 9786
- PDB-CCD: UAS
- NIKKAJI: J166.097G
- RefMet: Phenindione
- KNApSAcK: 8066
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Megan C Romano, Kyle A Francis, Jennifer G Janes, Robert H Poppenga, Michael S Filigenzi, Darko Stefanovski, Cynthia L Gaskill. Determining an approximate minimum toxic dosage of diphacinone in horses and corresponding serum, blood, and liver diphacinone concentrations: a pilot study.
Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc.
2022 May; 34(3):489-495. doi:
10.1177/10406387221086923. [PMID: 35369800] - Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
Cell reports.
2021 04; 35(4):109040. doi:
10.1016/j.celrep.2021.109040. [PMID: 33910017] - Tobie D Lee, Olivia W Lee, Kyle R Brimacombe, Lu Chen, Rajarshi Guha, Sabrina Lusvarghi, Bethilehem G Tebase, Carleen Klumpp-Thomas, Robert W Robey, Suresh V Ambudkar, Min Shen, Michael M Gottesman, Matthew D Hall. A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology.
2019 11; 96(5):629-640. doi:
10.1124/mol.119.115964. [PMID: 31515284] - Hongfang Li, Shuang Liu, Baolei Dong, Chenglong Li, Huijuan Yang, Xiya Zhang, Kai Wen, Xuezhi Yu, Wenbo Yu, Jianzhong Shen, Jiancheng Li, Zhanhui Wang. Production of a specific monoclonal antibody and a sensitive immunoassay for the detection of diphacinone in biological samples.
Analytical and bioanalytical chemistry.
2019 Oct; 411(25):6755-6765. doi:
10.1007/s00216-019-02051-2. [PMID: 31388716] - Timothy H Self, Ryan E Owens, Sami A Sakaan, Jessica L Wallace, Christopher W Sands, Amanda Howard-Thompson. Effect of diseases on response to vitamin K antagonists.
Current medical research and opinion.
2016; 32(4):613-20. doi:
10.1185/03007995.2015.1134464. [PMID: 26695107] - Balan Natarajan, Tanya Hart, Sophy Smith, Robin Geoffrey Parry. Phenindione interference in enzymatic creatinine assay - A case report.
Clinical nephrology.
2015 Feb; 83(2):121-3. doi:
10.5414/cn108108. [PMID: 24361058] - Xijuan Tan, Zhenghua Song, Donghua Chen, Airu Lv. Ultrasensitive determination of diphacinone by flow injection chemiluminescence: application to quantification in biofluids and photodegradation monitoring in water samples.
Journal of AOAC International.
2014 Nov; 97(6):1725-9. doi:
10.5740/jaoacint.12-123. [PMID: 25632450] - Barnett A Rattner, Katherine E Horak, Rebecca S Lazarus, David A Goldade, John J Johnston. Toxicokinetics and coagulopathy threshold of the rodenticide diphacinone in eastern screech-owls (Megascops asio).
Environmental toxicology and chemistry.
2014 Jan; 33(1):74-81. doi:
10.1002/etc.2390. [PMID: 24014246] - Laurent Chouchana, Eva Languille, Nicolas Weiss, Eliane M Billaud, Agnès Lillo-Le Louet. [Bleedings during vitamin K antagonist therapy associated with ciclosporin and rifampicin].
Presse medicale (Paris, France : 1983).
2013 May; 42(5):908-11. doi:
10.1016/j.lpm.2012.07.026. [PMID: 23069229] - Gérard Cam, Angèle Tchiango Kwetcheu, Cécile Vigneau, Pascale Siohan, Guillaume Queffeulou, Philippe Gatault, Eric Laruelle, Alain Crémault, Philippe Le Cacheux, Nathalie Rioux-Leclercq, Eric Renaudineau. Acute and chronic nephropathy induced by fluindione must be addressed.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2012 Apr; 27(4):1554-8. doi:
10.1093/ndt/gfr500. [PMID: 21931126] - Min Chen, Likun Gong, Xinming Qi, Guozhen Xing, Yang Luan, Yuanfeng Wu, Ying Xiao, Jun Yao, Yan Li, Xiang Xue, Guoyu Pan, Jin Ren. Inhibition of renal NQO1 activity by dicoumarol suppresses nitroreduction of aristolochic acid I and attenuates its nephrotoxicity.
Toxicological sciences : an official journal of the Society of Toxicology.
2011 Aug; 122(2):288-96. doi:
10.1093/toxsci/kfr138. [PMID: 21613233] - Meiqiang Cai, Xiaohong Chen, Micong Jin. An enhancement of europium-/gadolinium- diphacinone -DL-histidine- cetylpyridine bromide system for the determination of diphacinone in serum.
Journal of fluorescence.
2011 Jul; 21(4):1349-56. doi:
10.1007/s10895-011-0863-x. [PMID: 21340617] - Xiaohong Chen, Meiqiang Cai, Micong Jin. [Study on the enhancement diphacinone-europium fluorescence system and application for determination of the residue in urine].
Wei sheng yan jiu = Journal of hygiene research.
2011 Jul; 40(4):523-6. doi:
. [PMID: 21861363] - Barnett A Rattner, Katherine E Horak, Sarah E Warner, Daniel D Day, Carol U Meteyer, Steven F Volker, John D Eisemann, John J Johnston. Acute toxicity, histopathology, and coagulopathy in American kestrels (Falco sparverius) following administration of the rodenticide diphacinone.
Environmental toxicology and chemistry.
2011 May; 30(5):1213-22. doi:
10.1002/etc.490. [PMID: 21337606] - Nikolas Harbord. Novel nephrotoxins.
Advances in chronic kidney disease.
2011 May; 18(3):214-8. doi:
10.1053/j.ackd.2010.12.001. [PMID: 21531328] - NULL. Immunoallergic adverse effects of fluindione.
Prescrire international.
2010 Nov; 19(110):255-6. doi:
NULL. [PMID: 21284358] - Isabelle Fourel, Christophe Hugnet, Isabelle Goy-Thollot, Philippe Berny. Validation of a new liquid chromatography- tandem mass spectrometry ion-trap technique for the simultaneous determination of thirteen anticoagulant rodenticides, drugs, or natural products.
Journal of analytical toxicology.
2010 Mar; 34(2):95-102. doi:
10.1093/jat/34.2.95. [PMID: 20223102] - Micong Jin, Xiaohong Chen. [Simultaneous determination of trace diphacinone and chlorophacinone in biological samples by high performance liquid chromatography coupled with ion trap mass spectrometry].
Se pu = Chinese journal of chromatography.
2010 Feb; 28(2):197-203. doi:
10.3724/sp.j.1123.2012.00197. [PMID: 20556961] - ". Use the INN to avoid confusion between drugs.
Prescrire international.
2009 Oct; 18(103):214. doi:
". [PMID: 19882793] - Franck Reynaud, Patrick Giraud, Jean-Marc Cisterne, Daniel Verdier, Zeinab Kouchakipour, Alain Hermelin, Anne Modesto-Segonds, Haleh Bagheri, Jacques Pourrat. [Acute immuno-allergic interstitial nephritis after treatment with fluindione. Seven cases].
Nephrologie & therapeutique.
2009 Jul; 5(4):292-8. doi:
10.1016/j.nephro.2009.01.008. [PMID: 19357010] - Christine Beauchamp, Ioana Enache, Abraham Haskour, Laurent Martin. [Acute interstitial nephritis of fluindione: about three cases].
Nephrologie & therapeutique.
2008 Oct; 4(5):339-46. doi:
10.1016/j.nephro.2008.02.003. [PMID: 18417438] - J-F Cadranel, R Demontis, M Seddik, S Ramdani, D Belloula, M Biour. [Hepatic and renal toxicity to fluindione (Previscan)].
Gastroenterologie clinique et biologique.
2008 Oct; 32(10):816-8. doi:
10.1016/j.gcb.2008.07.003. [PMID: 18818035] - ". Colchicine: serious interactions.
Prescrire international.
2008 Aug; 17(96):151-3. doi:
". [PMID: 19492485] - L Chiche, G Thomas, S Canavese, S Branger, R Jean, J M Durand. Severe hemorrhagic syndrome due to similarity of drug names.
European journal of internal medicine.
2008 Mar; 19(2):135-6. doi:
10.1016/j.ejim.2007.03.018. [PMID: 18249310] - Jérémie Sellam, Nathalie Costedoat-Chalumeau, Zahir Amoura, Guy Aymard, Sylvain Choquet, Salim Trad, Bénédicte Lebrun Vignes, Jean-Sébastien Hulot, Francis Berenbaum, Philippe Lechat, Patrice Cacoub, Annick Ankri, Xavier Mariette, Véronique Leblond, Jean-Charles Piette. Potentiation of fluindione or warfarin by dexamethasone in multiple myeloma and AL amyloidosis.
Joint bone spine.
2007 Oct; 74(5):446-52. doi:
10.1016/j.jbspin.2006.12.006. [PMID: 17692552] - S Belmouaz, E Desport, R Abou Ayache, A Thierry, A Mignot, M Bauwens, J M Goujon, F Bridoux, G Touchard. Acute immuno-allergic interstitial nephritis caused by fluindione.
Clinical nephrology.
2006 Dec; 66(6):455-8. doi:
10.5414/cnp66455. [PMID: 17176918] - David Grimaldi, Eric Daugas, Béatrice Mougenot, Jérôme Rossert, Pierre Ronco. Immuno-allergic interstitial nephritis related to fluindione: first biopsy proven cases.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
2006 Jan; 21(1):237. doi:
10.1093/ndt/gfi173. [PMID: 16221711] - John J Johnston, William C Pitt, Robert T Sugihara, John D Eisemann, Thomas M Primus, Melvin J Holmes, Joe Crocker, Andy Hart. Probabilistic risk assessment for snails, slugs, and endangered honeycreepers in diphacinone rodenticide baited areas on Hawaii, USA.
Environmental toxicology and chemistry.
2005 Jun; 24(6):1557-67. doi:
10.1897/04-255r.1. [PMID: 16117137] - Henry A Spiller, G Leroy Gallenstein, Michael J Murphy. Dermal absorption of a liquid diphacinone rodenticide causing coagulaopathy.
Veterinary and human toxicology.
2003 Dec; 45(6):313-4. doi:
. [PMID: 14640483] - S Y Yang, G M Pan, G F Meng, D M Zhang. [Study of diphacinone in biological samples by high performance liquid chromatography/diode array detector].
Se pu = Chinese journal of chromatography.
2001 May; 19(3):245-7. doi:
. [PMID: 12541808] - M Alzieu, F Trivin, J Guglielminotti, B Guidet, G Offenstadt. [Serious complication of an illegible prescription].
Presse medicale (Paris, France : 1983).
2000 Jun; 29(22):1263. doi:
". [PMID: 10916541] - N Costedoat-Chalumeau, Z Amoura, G Aymard, O Sevin, B Wechsler, P Cacoub, L T Du, B Diquet, A Ankri, J C Piette. Potentiation of vitamin K antagonists by high-dose intravenous methylprednisolone.
Annals of internal medicine.
2000 Apr; 132(8):631-5. doi:
10.7326/0003-4819-132-8-200004180-00005. [PMID: 10766681] - G Aymard, M Legrand, E Comets, F Mentré, B Diquet. Rapid and simple micromethod for the quantification of fluindione in human plasma using high-performance liquid chromatography.
Journal of chromatography. B, Biomedical sciences and applications.
1998 Apr; 707(1-2):169-73. doi:
10.1016/s0378-4347(97)00587-2. [PMID: 9613946] - S S Tous, A M el-Sayed, S A el-Harras, H W Jun. Availability of phenindione-beta-cyclodextrin inclusion complex.
Die Pharmazie.
1992 May; 47(5):365-8. doi:
. [PMID: 1409827] - M E Mount, P H Kass. Diagnostic importance of vitamin K1 and its epoxide measured in serum of dogs exposed to an anticoagulant rodenticide.
American journal of veterinary research.
1989 Oct; 50(10):1704-9. doi:
. [PMID: 2802299] - A R Murthy, S D Wyrick, I H Hall. Hypolipidemic activity of indan-1,3-dione derivatives in rodents.
Journal of medicinal chemistry.
1985 Nov; 28(11):1591-6. doi:
10.1021/jm00149a008. [PMID: 4067989] - M Ia Ratner, N A Tomilina, L S Biriukova, S F Monchakovskiĭ. [Further study of the indications for combination cytostatic-anticoagulant-antiaggregation-corticosteroid therapy of chronic glomerulonephritis].
Terapevticheskii arkhiv.
1985; 57(6):69-74. doi:
NULL. [PMID: 4071418] - C C Yu, Y H Atallah, D M Whitacre. Metabolism and disposition of diphacinone in rats and mice.
Drug metabolism and disposition: the biological fate of chemicals.
1982 Nov; 10(6):645-8. doi:
. [PMID: 6130915] - J Paubel, P Niviere, M Payard, J C Rabadeux, C P Pinazzi. Interactions of some phenylindanedione anticoagulants with human serum albumin.
European journal of drug metabolism and pharmacokinetics.
1981; 6(4):241-8. doi:
10.1007/bf03189520. [PMID: 7333323] - R Garnier, A Castot, O Muzard, E Fournier. [Visceral injuries due to phenylindanedione. Three cases (author's transl)].
Therapie.
1980 May; 35(3):413-8. doi:
NULL. [PMID: 7423434] - D Storck, D Christmann, J M Vetter, D Kieffer, E Grosshans, J Warter. [Acute nephritis and allergic vasculitis due to phenindione (author's transl)].
La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris.
1979 Sep; 55(27-30):1330-4. doi:
. [PMID: 228409] - M J Serlin, R G Sibeon, S Mossman, A M Breckenridge, J R Williams, J L Atwood, J M Willoughby. Cimetidine: interaction with oral anticoagulants in man.
Lancet (London, England).
1979 Aug; 2(8138):317-9. doi:
10.1016/s0140-6736(79)90340-4. [PMID: 89387] - M F Horellou, P Feiss, J C Voultoury, R Gay. [Acute renal insufficiency caused by phenyl-indane-dione. Apropos of 1 case].
Annales de l'anesthesiologie francaise.
1978; 19(11-12):941-6. doi:
. [PMID: 35076] - D Kleinknecht, A Kanfer, L Morel-Maroger, J P Méry. Immunologically mediated drug-induced acute renal failure.
Contributions to nephrology.
1978; 10(?):42-52. doi:
10.1159/000401522. [PMID: 27331] - C Ponticelli, O Maestri, E Imbasciati, D Brancaccio, E Rossi. Late recovery of renal function in a woman with the hemolytic uremic syndrome.
Clinical nephrology.
1977 Aug; 8(2):367-70. doi:
NULL. [PMID: 891050] - A Kinawi. [Determination of 3-(1'-phenylpropyl)-4-hydroxycoumarin by means of high-performance liquid chromatography (HPLC) (author's transl)].
Arzneimittel-Forschung.
1977 Feb; 27(2):360-3. doi:
. [PMID: 577154] - H Krug, J Głuszek, C Smarsz, K Jasiński. A study of the catabolism of fibrinogen after myocardial infarction.
Cor et vasa.
1977; 19(4-5):281-90. doi:
NULL. [PMID: 598201] - P A Gover, G I Ingram, M S Cork, L Holland, R P Hopkins, P Callaghan, P Barkhan, M J Shearer. Bleeding from self-administration of phenindione: a detailed case study.
British journal of haematology.
1976 Aug; 33(4):551-64. doi:
10.1111/j.1365-2141.1976.tb03574.x. [PMID: 1009028] - R Zini, P d'Athis, A Hoareau, J P Tillement. Binding of four sulphonamides to human albumin.
European journal of clinical pharmacology.
1976 Jun; 10(2):139-45. doi:
10.1007/bf00609473. [PMID: 964290] - R W Bullard, R D Thompson, G Holguin. Diphenadione residues in tissues of cattle.
Journal of agricultural and food chemistry.
1976 Mar; 24(2):261-3. doi:
10.1021/jf60204a010. [PMID: 946430] - D Chevet, M Garré, R Thomas, M P Ramée, J Goasguen, P Alquier. [Letter: Phenylindanedione-induced nephropathies. Value of the leukocyte migration inhibition test].
La Nouvelle presse medicale.
1976 Feb; 5(9):588. doi:
NULL. [PMID: 1264730] - L Skovsted, M Kristensen, M Hansen, K Siersbaek-Nielsen. The effect of different oral anticoagulants on diphenylhydantoin (DPH) and tolbutamide metabolism.
Acta medica Scandinavica.
1976; 199(6):513-5. doi:
10.1111/j.0954-6820.1976.tb06772.x. [PMID: 59517] - F Joram, G Le Bihan, J Bourreille. [Acute nephropathy caused by phenindione intolerance. Apropos of a recent case].
Semaine des hopitaux. Therapeutique.
1976 Jan; 52(1):19-22. doi:
. [PMID: 1257797] - P Bret, J Lecuire, C Lapras, R Deruty, M Desgeorges, J L Prudhon. [Subdural hematoma and anticoagulant therapy].
Neuro-Chirurgie.
1976; 22(6):603-20. doi:
. [PMID: 67569] - R Laliberté, S Chakrabarti, J Brodeur. The influence of fasting and stress on the response of rats to warfarin.
The Journal of pharmacology and experimental therapeutics.
1976 Jan; 196(1):194-203. doi:
. [PMID: 54416] - D R Varma, R K Gupta, S Gupta. Prothrombin response to phenindione during hypoalbuminaemia.
British journal of clinical pharmacology.
1975 Oct; 2(5):467-8. doi:
10.1111/j.1365-2125.1975.tb00558.x. [PMID: 1233073] - J P Tillement, J J Thébault, C Mattei, P d'Athis, C Blatrix. Anticoagulant effect and plasma kinetics of fluorophenindione after a single dose in man.
European journal of clinical pharmacology.
1975 Apr; 8(3-4):271-5. doi:
10.1007/bf00567127. [PMID: 1233224] - R D Eastham. The efficacy of long-term oral anticoagulant therapy and its laboratory assessment.
Journal of clinical pathology.
1975 Mar; 28(3):198-201. doi:
10.1136/jcp.28.3.198. [PMID: 1123447] - R W Bullard, G Holguin, J E Peterson. Determination of chlorophacinone and diphenadione residues in biological materials.
Journal of agricultural and food chemistry.
1975 Jan; 23(1):72-4. doi:
10.1021/jf60197a011. [PMID: 1173369] - C Ponticelli, E Imbasciati, D Brancaccio, A Tarantino, E Rivolta. Acute renal failure in systemic lupus erythematosus.
British medical journal.
1974 Sep; 3(5933):716-9. doi:
10.1136/bmj.3.5933.716. [PMID: 4411854] - J P Tillement, C Mattei, R Zini. Effect of sodium chlorophenoxyisobutyrate on the binding of vitamin K antagonists to human albumin in vitro.
Experientia.
1974 May; 30(5):460-1. doi:
10.1007/bf01926292. [PMID: 4833656] - J Judis. Displacement of sulfonylureas from human serum proteins by coumarin derivatives and cortical steroids.
Journal of pharmaceutical sciences.
1973 Feb; 62(2):232-7. doi:
10.1002/jps.2600620210. [PMID: 4119680] - A Leblanc, A Vernet. [Nephrotoxicity of drugs. 3].
Schweizerische Rundschau fur Medizin Praxis = Revue suisse de medecine Praxis.
1973 Jan; 62(4):93-100. doi:
NULL. [PMID: 4630987] - E Jacobsen, K H Klevan. Electroreduction and polarographic determination of 2-phenylindan-1,3-dione in serum.
Analytica chimica acta.
1972 Dec; 62(2):405-13. doi:
10.1016/0003-2670(72)80049-7. [PMID: 4635229] - J D Sraer, P Beaufils, L M Maroger, G Richet. [Chronic interstitial nephritis due to phenylindanedione following an acute renal insufficiency].
La Nouvelle presse medicale.
1972 Jan; 1(3):193-6. doi:
. [PMID: 5061531] - A I Arieff, W F Pinggera. Rapidly progressive glomerulonephritis treated with anticoagulants.
Archives of internal medicine.
1972 Jan; 129(1):77-84. doi:
NULL. [PMID: 4550298] - K W Denson. The levels of factors II, VII, IX and X by antibody neutralization techniques in the plasma of patients receiving phenindione therapy.
British journal of haematology.
1971 Jun; 20(6):643-8. doi:
10.1111/j.1365-2141.1971.tb00803.x. [PMID: 5089955] - C Klepping, C Bourgeaux, J Villand, H Carli. [New case of acute kidney failure due to phenindione].
Annales de medecine interne.
1971 Mar; 122(3):439-44. doi:
. [PMID: 5555847] - P Kincaid-Smith. The pathogenesis of the vascular and glomerular lesions of rejection in renal allografts and their modification by antithromtotic and anticoagulant drugs.
Australasian annals of medicine.
1970 Aug; 19(3):201-14. doi:
10.1111/imj.1970.19.3.201. [PMID: 4394286] - J S Wright. Phenindione sensitivity with leukaemoid reaction and hepato-renal damage.
Postgraduate medical journal.
1970 Jul; 46(537):452-5. doi:
10.1136/pgmj.46.537.452. [PMID: 4248923] - M G Nicholls, W F Heale. Phenindione sensitivity and acute renal failure.
The New Zealand medical journal.
1970 Apr; 71(455):214-6. doi:
. [PMID: 5270600] - N Zöllner, W Gröbner. [The effect of coumarin, indandione and benzofuran derivatives on renal excretion of uric acid].
Deutsche medizinische Wochenschrift (1946).
1969 Dec; 94(51):2652-4. doi:
NULL. [PMID: 4190226] - P Kincaid-Smith. Modification of the vascular lesions of rejection in cadaveric renal allografts by dipyridamole and anticoagulants.
Lancet (London, England).
1969 Nov; 2(7627):920-2. doi:
10.1016/s0140-6736(69)90587-x. [PMID: 4186594] - R S Nanra, D Clyne, P Kincaid-Smith. The use of the modified PSP excretion test in the clinical management of patients with renal allografts.
The Medical journal of Australia.
1969 May; 1(21):1083-7. doi:
NULL. [PMID: 4893352] - B Dixneuf, J Guimbretière, M Dehorne. [About a case of intolerance in a premedication. Demonstration of antipethidine antibodies].
Anesthesie, analgesie, reanimation.
1969 May; 26(3):437-44. doi:
NULL. [PMID: 5804831] - P Kincaid-Smith, B M Saker, K F Fairley. Anticoagulants in 'irreversible' acute renal failure.
Lancet (London, England).
1968 Dec; 2(7583):1360-3. doi:
10.1016/s0140-6736(68)92671-8. [PMID: 4177930] - G Manigand, P Auzépy, C Lardy. [A case of serious intolerance during treatment by phenindione: preventive measures to be taken].
La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris.
1968 Dec; 44(52):3217-22. doi:
NULL. [PMID: 4307331] - C Blatrix, J P Tillement, J Israel, S Charonnat. [The metabolism of antivitamin K].
Revue francaise d'etudes cliniques et biologiques.
1968 Jun; 13(6):568-74. doi:
NULL. [PMID: 4177710] - J Traeger, P Zech, P Touboul. [Toxiallergic renal complications in anticoagulant treatment with phenyl-indane-dione. Occurrence. Treatment. Prevention. 1 case of acute renal insufficiency].
Therapie.
1968 May; 23(3):511-23. doi:
NULL. [PMID: 5741503] - A Doni, L Bartoletti, A Biddau. [Experimental hematuria in the rat, caused by cold stress associated with phenylindanedione].
Rivista critica di clinica medica.
1967 Oct; 67(5):325-35. doi:
. [PMID: 5604184] - A I Spriggs, D W Jerrome. Electron-microscopy of Türk cells.
British journal of haematology.
1967 Sep; 13(5):764-7. doi:
10.1111/j.1365-2141.1967.tb08842.x. [PMID: 6057665] - O M Orning, P R Syse, P F Hjort. [Side effects of phenindione (Trombantin)].
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke.
1967 Jul; 87(14):1273-6. doi:
NULL. [PMID: 6046772] - S Padmavati, I Sandhu. Effect of various commonly used medications on serum cholesterol levels in human beings.
The Indian journal of medical research.
1967 Jul; 55(7):692-8. doi:
NULL. [PMID: 6056279] - C Huriet. [Drug-induced nephropathies].
La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris.
1967 May; 43(22):1506-7. doi:
NULL. [PMID: 4292995] - R J Lewis, M Spivack, T H Spaet. Warfarin resistance.
The American journal of medicine.
1967 Apr; 42(4):620-4. doi:
10.1016/0002-9343(67)90061-7. [PMID: 6023007] - R L Walker, F W Rost. Phenindione therapy and haematuria.
The Medical journal of Australia.
1965 Oct; 2(18):755-6. doi:
10.5694/j.1326-5377.1965.tb19226.x. [PMID: 5846224] - K SMITH. ACUTE RENAL FAILURE IN PHENINDIONE SENSITIVITY.
British medical journal.
1965 Jul; 2(5452):24-6. doi:
10.1136/bmj.2.5452.20. [PMID: 14305347] - S A FOLLETT. OLIGURIA DUE TO A HYPERSENSITIVITY REACTION TO PHENINDIONE.
Nursing times.
1964 Oct; 60(?):1420-2. doi:
. [PMID: 14208549] - R M NAKAMURA, G M KUNITAKE, K FUJITA, E B REILLY. PLASMA-FIBRINOGEN LEVELS AFTER LONG-TERM WARFARIN THERAPY.
Lancet (London, England).
1964 Oct; 2(7363):821-2. doi:
10.1016/s0140-6736(64)90604-x. [PMID: 14187489] - R D EASTHAM, E H MORGAN. PLASMA HYPERCOAGULABILITY IN PATIENTS WITH CARCINOMA AND AFTER HAEMORRHAGE.
Lancet (London, England).
1964 Sep; 2(7359):543-4. doi:
10.1016/s0140-6736(64)90615-4. [PMID: 14172344] - O BUSCHMANN, E WILLICH. [PHENINDIONE NEPHROPATHY].
Deutsche medizinische Wochenschrift (1946).
1964 Aug; 89(?):1658-9. doi:
NULL. [PMID: 14172161] - H A LEE, C E HOLDEN. PHENINDIONE NEPHROPATHY WITH RECOVERY: STUDIES OF MORPHOLOGY AND RENAL FUNCTION.
Postgraduate medical journal.
1964 Jun; 40(?):327-31. doi:
10.1136/pgmj.40.464.326. [PMID: 14154953] - M H ROSCOE. URINE IN ACUTE AND CHRONIC RENAL FAILURE.
British medical journal.
1964 Apr; 1(5390):1084-7. doi:
10.1136/bmj.1.5390.1084. [PMID: 14113823] - R C COTTON, E G WADE. EFFECT OF SUDDEN WITHDRAWAL OF LONG-TERM ANTICOAGULANT THERAPY ON THE HEPARIN RESISTANCE AND PLASMA FIBRINOGEN LEVEL.
Clinical science.
1964 Apr; 26(?):337-43. doi:
NULL. [PMID: 14162427] - B C BOSE, A Q SAIFI. STUDIES ON THE METABOLISM OF PHENINDIONE.
Indian journal of medical sciences.
1964 Feb; 18(?):86-7. doi:
NULL. [PMID: 14126209] - F VALDORF-HANSEN, I HOYER, H W LARSEN. LONG-TERM ANTICOAGULANT THERAPY IN DIABETIC RETINOPATHY.
Acta ophthalmologica.
1964; 42(?):579-87. doi:
10.1111/j.1755-3768.1964.tb00906.x. [PMID: 14186612] - M N KOPTELOVA. OMEPHINE, A NEW ANTICOAGULANT.
Federation proceedings. Translation supplement; selected translations from medical-related science.
1963 Nov; 22(?):1256-8. doi:
NULL. [PMID: 14079350] - H C GODAL, U ABILDGAARD. THE SYMPTOMATIC EFFECT OF ANTICOAGULANT THERAPY IN DEFIBRINATION SYNDROME ASSOCIATED WITH DEMONSTRABLE FIBRIN IN PLASMA: A CASE REPORT.
Acta medica Scandinavica.
1963 Sep; 174(?):311-4. doi:
10.1111/j.0954-6820.1963.tb07928.x. [PMID: 14058757] - R C COTTON, E G WADE, G W SPILLER. THE EFFECT OF ATROMID ON PLASMA FIBRINOGEN AND HEPARIN RESISTANCE.
Journal of atherosclerosis research.
1963 Sep; 3(?):648-52. doi:
10.1016/s0368-1319(63)80048-4. [PMID: 14100908]
