Ketanserin (BioDeep_00000006504)
Secondary id: BioDeep_00001868528
human metabolite blood metabolite
代谢物信息卡片
3-{2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl}-1,2,3,4-tetrahydroquinazoline-2,4-dione
化学式: C22H22FN3O3 (395.1645)
中文名称: 凯他色林
谱图信息:
最多检出来源 Mus musculus(blood) 75%
分子结构信息
SMILES: c1ccc2c(c1)c(=O)n(CCN1CCC(CC1)C(=O)c1ccc(cc1)F)c(=O)[nH]2
InChI: InChI=1S/C22H22FN3O3/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29)
描述信息
C - Cardiovascular system > C02 - Antihypertensives > C02K - Other antihypertensives > C02KD - Serotonin antagonists
D018377 - Neurotransmitter Agents > D018490 - Serotonin Agents > D012702 - Serotonin Antagonists
D006401 - Hematologic Agents > D010975 - Platelet Aggregation Inhibitors
C78272 - Agent Affecting Nervous System > C66885 - Serotonin Antagonist
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
Ketanserin is a selective 5-HT2 receptor antagonist. Ketanserin also blocks hERG current (IhERG) in a concentration-dependent manner (IC50=0.11 μM).
同义名列表
10 个代谢物同义名
3-{2-[4-(4-fluorobenzoyl)piperidin-1-yl]ethyl}-1,2,3,4-tetrahydroquinazoline-2,4-dione; 3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H,3H)-quinazolinedione; 3-[2-[4-(4-Fluorobenzoyl)-1-piperidyl]ethyl]-1H-quinazoline-2,4-dione; Ketanserinum; Ketanserine; Ketanserina; Ketanserin; R41468; Ketanserin; Ketanserin
数据库引用编号
18 个数据库交叉引用编号
- ChEBI: CHEBI:6123
- KEGG: C07464
- KEGGdrug: D02363
- PubChem: 3822
- HMDB: HMDB0253783
- Metlin: METLIN889
- DrugBank: DB12465
- ChEMBL: CHEMBL51
- Wikipedia: Ketanserin
- MeSH: Ketanserin
- CAS: 74050-98-9
- PMhub: MS000019553
- PubChem: 9667
- PDB-CCD: UYX
- NIKKAJI: J12.099E
- RefMet: Ketanserin
- medchemexpress: HY-10562
- KNApSAcK: 6123
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
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10.4070/kcj.2011.41.10.590. [PMID: 22125558] - Kamal S Bhatia, Steven T Szabo, J Corey Fowler, William C Wetsel, Tong H Lee. Reversal of long-term methamphetamine sensitization by combination of pergolide with ondansetron or ketanserin, but not mirtazapine.
Behavioural brain research.
2011 Sep; 223(1):227-32. doi:
10.1016/j.bbr.2011.04.045. [PMID: 21571009] - M A Santini, A B Klein, M El-Sayed, C Ratner, G M Knudsen, J D Mikkelsen, S Aznar. Novelty-induced activity-regulated cytoskeletal-associated protein (Arc) expression in frontal cortex requires serotonin 2A receptor activation.
Neuroscience.
2011 Sep; 190(?):251-7. doi:
10.1016/j.neuroscience.2011.05.048. [PMID: 21664256] - Yoshihiro Nagao, Tomohiko Akahoshi, Masahiro Kamori, Hideo Uehara, Naotaka Hashimoto, Nao Kinjo, Ken Shirabe, Akinobu Taketomi, Morimasa Tomikawa, Makoto Hashizume, Yoshihiko Maehara. Liver regeneration is promoted by increasing serotonin content in rat liver with secondary biliary cirrhosis.
Hepatology research : the official journal of the Japan Society of Hepatology.
2011 Aug; 41(8):784-94. doi:
10.1111/j.1872-034x.2011.00828.x. [PMID: 21699634] - T R Anju, P K Korah, S Jayanarayanan, C S Paulose. Enhanced brain stem 5HT₂A receptor function under neonatal hypoxic insult: role of glucose, oxygen, and epinephrine resuscitation.
Molecular and cellular biochemistry.
2011 Aug; 354(1-2):151-60. doi:
10.1007/s11010-011-0814-5. [PMID: 21484469] - David Erritzoe, Vibe G Frokjaer, Klaus K Holst, Maria Christoffersen, Sys S Johansen, Claus Svarer, Jacob Madsen, Peter M Rasmussen, Thomas Ramsøy, Terry L Jernigan, Gitte M Knudsen. In vivo imaging of cerebral serotonin transporter and serotonin(2A) receptor binding in 3,4-methylenedioxymethamphetamine (MDMA or "ecstasy") and hallucinogen users.
Archives of general psychiatry.
2011 Jun; 68(6):562-76. doi:
10.1001/archgenpsychiatry.2011.56. [PMID: 21646575] - Zeyad D Nassar, Abdalrahim Fa Aisha, Mohamed Bk Ahamed, Zhari Ismail, Khalid M Abu-Salah, Salman A Alrokayan, Amin Malik Shah Abdul Majid. Antiangiogenic properties of Koetjapic acid, a natural triterpene isolated from Sandoricum koetjaoe Merr.
Cancer cell international.
2011 Apr; 11(1):12. doi:
10.1186/1475-2867-11-12. [PMID: 21524294] - Hans Rasmussen, Bjorn H Ebdrup, David Erritzoe, Bodil Aggernaes, Bob Oranje, Jan Kalbitzer, Lars H Pinborg, William F C Baaré, Claus Svarer, Henrik Lublin, Gitte M Knudsen, Birte Glenthoj. Serotonin2A receptor blockade and clinical effect in first-episode schizophrenia patients treated with quetiapine.
Psychopharmacology.
2011 Feb; 213(2-3):583-92. doi:
10.1007/s00213-010-1941-5. [PMID: 20614105] - Fatemeh Talaei, Hjalmar R Bouma, Adrianus C Van der Graaf, Arjen M Strijkstra, Martina Schmidt, Robert H Henning. Serotonin and dopamine protect from hypothermia/rewarming damage through the CBS/H2S pathway.
PloS one.
2011; 6(7):e22568. doi:
10.1371/journal.pone.0022568. [PMID: 21829469] - Déanne Malenfant, Kelly Summers, Shannon Seney, Donna McBain, Lisa Petrlich, Sharon Watson, Louise Vanderhoek, Nooshin Samadi, Ashley Bonner, Janet Pope. Results of a Pilot Randomized Placebo-Controlled Trial in Primary and Secondary Raynaud's Phenomenon with St. John's Wort: Detecting Changes in Angiogenic Cytokines When RP Improves.
ISRN rheumatology.
2011; 2011(?):580704. doi:
10.5402/2011/580704. [PMID: 22389797] - Iida Peltonen, Pekka T Männistö. Effects of diverse psychopharmacological substances on the activity of brain prolyl oligopeptidase.
Basic & clinical pharmacology & toxicology.
2011 Jan; 108(1):46-54. doi:
10.1111/j.1742-7843.2010.00626.x. [PMID: 20825390] - Sylwia Lukasiewicz, Agnieszka Polit, Sylwia Kędracka-Krok, Krzysztof Wędzony, Marzena Maćkowiak, Marta Dziedzicka-Wasylewska. Hetero-dimerization of serotonin 5-HT(2A) and dopamine D(2) receptors.
Biochimica et biophysica acta.
2010 Dec; 1803(12):1347-58. doi:
10.1016/j.bbamcr.2010.08.010. [PMID: 20831885] - L S Lopes, R B Marques, S S Pereira, M C C Ayres, M H Chaves, A J Cavalheiro, G M Vieira Júnior, F R C Almeida. Antinociceptive effect on mice of the hydroalcoholic fraction and (-) epicatechin obtained from Combretum leprosum Mart & Eich.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.
2010 Dec; 43(12):1184-92. doi:
10.1590/s0100-879x2010007500121. [PMID: 21180806] - Anders Bue Klein, Viktorija Trajkovska, David Erritzoe, Steven Haugbol, Jacob Madsen, William Baaré, Susana Aznar, Gitte M Knudsen. Cerebral 5-HT2A receptor and serotonin transporter binding in humans are not affected by the val66met BDNF polymorphism status or blood BDNF levels.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
2010 Nov; 30(11):e1-7. doi:
10.1038/jcbfm.2010.114. [PMID: 20736957] - Vibe G Frokjaer, David Erritzoe, Anders Juul, Finn Arup Nielsen, Klaus Holst, Claus Svarer, Jacob Madsen, Olaf B Paulson, Gitte M Knudsen. Endogenous plasma estradiol in healthy men is positively correlated with cerebral cortical serotonin 2A receptor binding.
Psychoneuroendocrinology.
2010 Oct; 35(9):1311-20. doi:
10.1016/j.psyneuen.2010.03.002. [PMID: 20356681] - Juliano C Capra, Mauricio P Cunha, Daniele G Machado, Andrea D E Zomkowski, Beatriz G Mendes, Adair Roberto S Santos, Moacir G Pizzolatti, Ana Lúcia S Rodrigues. Antidepressant-like effect of scopoletin, a coumarin isolated from Polygala sabulosa (Polygalaceae) in mice: evidence for the involvement of monoaminergic systems.
European journal of pharmacology.
2010 Sep; 643(2-3):232-8. doi:
10.1016/j.ejphar.2010.06.043. [PMID: 20599906] - Pretty Mary Abraham, Korah P Kuruvilla, Jobin Mathew, Anitha Malat, Shilpa Joy, C S Paulose. Alterations in hippocampal serotonergic and INSR function in streptozotocin induced diabetic rats exposed to stress: neuroprotective role of pyridoxine and Aegle marmelose.
Journal of biomedical science.
2010 Sep; 17(?):78. doi:
10.1186/1423-0127-17-78. [PMID: 20868513] - Emma Felixsson, Ingrid A-L Persson, Andreas C Eriksson, Karin Persson. Horse chestnut extract contracts bovine vessels and affects human platelet aggregation through 5-HT(2A) receptors: an in vitro study.
Phytotherapy research : PTR.
2010 Sep; 24(9):1297-301. doi:
10.1002/ptr.3103. [PMID: 20148408] - Eduardo R Butelman, Szymon Rus, Thomas E Prisinzano, Mary Jeanne Kreek. The discriminative effects of the kappa-opioid hallucinogen salvinorin A in nonhuman primates: dissociation from classic hallucinogen effects.
Psychopharmacology.
2010 Jun; 210(2):253-62. doi:
10.1007/s00213-009-1771-5. [PMID: 20084367] - Marios P Hadjicharalambous, Liam P Kilduff, Yannis P Pitsiladis. Brain serotonergic and dopaminergic modulators, perceptual responses and endurance exercise performance following caffeine co-ingested with a high fat meal in trained humans.
Journal of the International Society of Sports Nutrition.
2010 May; 7(?):22. doi:
10.1186/1550-2783-7-22. [PMID: 20507554] - Andiara E Freitas, Josiane Budni, Kelly R Lobato, Ricardo W Binfaré, Daniele G Machado, Jardel Jacinto, Patrícia O Veronezi, Moacir G Pizzolatti, Ana Lúcia S Rodrigues. Antidepressant-like action of the ethanolic extract from Tabebuia avellanedae in mice: evidence for the involvement of the monoaminergic system.
Progress in neuro-psychopharmacology & biological psychiatry.
2010 Mar; 34(2):335-43. doi:
10.1016/j.pnpbp.2009.12.010. [PMID: 20026371] - David Erritzoe, Klaus Holst, Vibe G Frokjaer, Cecilie L Licht, Jan Kalbitzer, Finn A Nielsen, Claus Svarer, Jacob Madsen, Gitte Knudsen. A nonlinear relationship between cerebral serotonin transporter and 5-HT(2A) receptor binding: an in vivo molecular imaging study in humans.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
2010 Mar; 30(9):3391-7. doi:
10.1523/jneurosci.2852-09.2010. [PMID: 20203198] - Shu-Wei Song, Ai-Jun Liu, Chong Bai, Bei-Lin Su, Xiu-Juan Ma, Fu-Ming Shen, Jun-Li Duan, Ding-Feng Su. Blood pressure reduction combining baroreflex restoration for stroke prevention in hypertension in rats.
Frontiers in pharmacology.
2010; 1(?):6. doi:
10.3389/fphar.2010.00006. [PMID: 21713105] - Arnt F A Schellekens, K P Grootens, C Neef, Kris L L Movig, J K Buitelaar, B Ellenbroek, R J Verkes. Effect of apomorphine on cognitive performance and sensorimotor gating in humans.
Psychopharmacology.
2010 Jan; 207(4):559-69. doi:
10.1007/s00213-009-1686-1. [PMID: 19834690] - Katharina Heimes, Björn Feistel, Eugen J Verspohl. Impact of the 5-HT3 receptor channel system for insulin secretion and interaction of ginger extracts.
European journal of pharmacology.
2009 Dec; 624(1-3):58-65. doi:
10.1016/j.ejphar.2009.09.049. [PMID: 19818348] - Zhiqian Yu, Mami Ohba, Masanori Nakamura, Takashi Sasano, Masao Ono, Shunji Sugawara, Yasuo Endo. Dynamics of platelet mobilisation into lungs in response to 5-hydroxytryptamine (serotonin) in mice.
Thrombosis and haemostasis.
2009 Dec; 102(6):1251-8. doi:
10.1160/th08-06-0406. [PMID: 19967158] - Kumi Moriyama, Jia Liu, Yeon Jang, Yun Jeong Chae, Yan Wang, James Mitchell, Stefan Grond, Xiaokang Han, Yilei Xing, Guo-xi Xie, Pamela Pierce Palmer. Receptor mediation and nociceptin inhibition of bradykinin-induced plasma extravasation in the knee joint of the rat.
Inflammation research : official journal of the European Histamine Research Society ... [et al.].
2009 Dec; 58(12):873-80. doi:
10.1007/s00011-009-0058-y. [PMID: 19544046] - Katsumi Kadekawa, Saori Nishijima, Kimio Sugaya, Minoru Miyazato, Seiichi Saito. Mechanisms by which the serotonergic system inhibits micturition in rats.
Life sciences.
2009 Oct; 85(15-16):592-6. doi:
10.1016/j.lfs.2009.08.013. [PMID: 19732780] - Lekshmi Santhosh, Kristina M Estok, Rebecca S Vogel, Gilles D Tamagnan, Ronald M Baldwin, Effie M Mitsis, Martha G Macavoy, Julie K Staley, Christopher H van Dyck. Regional distribution and behavioral correlates of 5-HT(2A) receptors in Alzheimer's disease with [(18)F]deuteroaltanserin and PET.
Psychiatry research.
2009 Sep; 173(3):212-7. doi:
10.1016/j.pscychresns.2009.03.007. [PMID: 19682865] - Hitomi Kanno, Kyoji Sekiguchi, Takuji Yamaguchi, Kiyoshi Terawaki, Mitsutoshi Yuzurihara, Yoshio Kase, Yasushi Ikarashi. Effect of yokukansan, a traditional Japanese medicine, on social and aggressive behaviour of para-chloroamphetamine-injected rats.
The Journal of pharmacy and pharmacology.
2009 Sep; 61(9):1249-56. doi:
10.1211/jpp/61.09.0016. [PMID: 19703376] - Juliana A T Werner, Sara M Oliveira, Daniel F Martins, Leidiane Mazzardo, Josiane de F G Dias, Ana L L Lordello, Obdúlio G Miguel, Luiz Fernando Royes, Juliano Ferreira, Adair R S Santos. Evidence for a role of 5-HT(1A) receptor on antinociceptive action from Geissospermum vellosii.
Journal of ethnopharmacology.
2009 Aug; 125(1):163-9. doi:
10.1016/j.jep.2009.05.026. [PMID: 19497357] - Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka, Howard R Miller, Ayman El-Kattan. Physicochemical determinants of human renal clearance.
Journal of medicinal chemistry.
2009 Aug; 52(15):4844-52. doi:
10.1021/jm900403j. [PMID: 19445515] - Daniele G Machado, Luis E B Bettio, Mauricio P Cunha, Juliano C Capra, Juliana B Dalmarco, Moacir G Pizzolatti, Ana Lúcia S Rodrigues. Antidepressant-like effect of the extract of Rosmarinus officinalis in mice: involvement of the monoaminergic system.
Progress in neuro-psychopharmacology & biological psychiatry.
2009 Jun; 33(4):642-50. doi:
10.1016/j.pnpbp.2009.03.004. [PMID: 19286446] - Stephanie W Watts, Jessica R C Priestley, Janice M Thompson. Serotonylation of vascular proteins important to contraction.
PloS one.
2009 May; 4(5):e5682. doi:
10.1371/journal.pone.0005682. [PMID: 19479059] - L M Kozhevnikova, A G Davydova, P V Avdonin. [Plasma membrane depolarization and activation of receptors for endogenous vasoconstrictors as possible mechanisms of potentiation of vasoconstrictive response to serotonin in traumatic shock in rats].
Izvestiia Akademii nauk. Seriia biologicheskaia.
2009 May; ?(3):343-57. doi:
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Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.
2009 Apr; 67(4):598-601. doi:
10.1016/j.apradiso.2008.12.007. [PMID: 19162492] - Kuo-Ping Shen, Hui-Li Lin, Su-Ling Hsieh, Aij-Lie Kwan, Ing-Jun Chen, Bin-Nan Wu. Eugenosedin-A prevents hyperglycaemia, hyperlipidaemia and lipid peroxidation in C57BL/6J mice fed a high-fat diet.
The Journal of pharmacy and pharmacology.
2009 Apr; 61(4):517-25. doi:
10.1211/jpp/61.04.0015. [PMID: 19298700] - Haruhiko Sugino, Takashi Futamura, Yasuhide Mitsumoto, Kenji Maeda, Yoshinori Marunaka. Atypical antipsychotics suppress production of proinflammatory cytokines and up-regulate interleukin-10 in lipopolysaccharide-treated mice.
Progress in neuro-psychopharmacology & biological psychiatry.
2009 Mar; 33(2):303-7. doi:
10.1016/j.pnpbp.2008.12.006. [PMID: 19138716] - Lip Yong Chung, Mee Wah Lo, Muhammad Rais Mustafa, Swee Hock Goh, Zamrie Imiyabir. 5-Hydroxytryptamine2A receptor binding activity of compounds from Litsea sessilis.
Phytotherapy research : PTR.
2009 Mar; 23(3):330-4. doi:
10.1002/ptr.2627. [PMID: 18844258] - René Hurlemann, Thomas E Schlaepfer, Andreas Matusch, Harald Reich, Nadim J Shah, Karl Zilles, Wolfgang Maier, Andreas Bauer. Reduced 5-HT(2A) receptor signaling following selective bilateral amygdala damage.
Social cognitive and affective neuroscience.
2009 Mar; 4(1):79-84. doi:
10.1093/scan/nsn039. [PMID: 19015089] - Tomoko Hibino, Mitsutoshi Yuzurihara, Hitomi Kanno, Yoshio Kase, Atsushi Takeda. Goshuyuto, a traditional Japanese medicine, and aqueous extracts of Evodiae Fructus constrict isolated rat aorta via adrenergic and/or serotonergic receptors.
Biological & pharmaceutical bulletin.
2009 Feb; 32(2):237-41. doi:
10.1248/bpb.32.237. [PMID: 19182382] - Nader Nouri-Majalan, Ehsan Fotouhi Ardakani, Khalil Forouzannia, Hosein Moshtaghian. Effects of allopurinol and vitamin E on renal function in patients with cardiac coronary artery bypass grafts.
Vascular health and risk management.
2009; 5(2):489-94. doi:
10.2147/vhrm.s5761. [PMID: 19554089] - Meritxell Canals, Juan F Lopez-Gimenez, Graeme Milligan. Cell surface delivery and structural re-organization by pharmacological chaperones of an oligomerization-defective alpha(1b)-adrenoceptor mutant demonstrates membrane targeting of GPCR oligomers.
The Biochemical journal.
2009 Jan; 417(1):161-72. doi:
10.1042/bj20081227. [PMID: 18764782] - Dean Papaliodis, William Boucher, Duraisamy Kempuraj, Margaret Michaelian, Adams Wolfberg, Michael House, Theoharis C Theoharides. Niacin-induced 'flush' involves release of prostaglandin D2 from mast cells and serotonin from platelets: evidence from human cells in vitro and an animal model.
The Journal of pharmacology and experimental therapeutics.
2008 Dec; 327(3):665-72. doi:
10.1124/jpet.108.141333. [PMID: 18784348] - E J Verspohl, M Ploch, T Windeck, M Klaes, T Schmidt, K Bauer. Effect of two artichoke extracts (36_U and 36_EB) on rat ileum (with respect to bowel syndrome) and the peristaltic threshold.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2008 Nov; 15(11):1002-9. doi:
10.1016/j.phymed.2008.02.011. [PMID: 18424104] - Christopher S Knauer, Jeffrey E Campbell, Betsy Galvan, Christopher Bowman, Sarah Osgood, Susan Buist, Lisa Buchholz, Brian Henry, Erik H F Wong, Mohammed Shahid, Sarah Grimwood. Validation of a rat in vivo [(3)H]M100907 binding assay to determine a translatable measure of 5-HT(2A) receptor occupancy.
European journal of pharmacology.
2008 Sep; 591(1-3):136-41. doi:
10.1016/j.ejphar.2008.06.063. [PMID: 18593577]
