5-Guanylylmethylenediphosphonate (BioDeep_00000006180)

   


代谢物信息卡片


Guanosine 5-monophosphate, monoanhydride with (phosphonomethyl)phosphonic acid

  化学式: C11H18N5O13P3 (521.0114)
中文名称:
  谱图信息: 最多检出来源 Pteris henryi Christ(plant) 9.84%

分子结构信息

SMILES: C1=NC2=C(N1C3C(C(C(O3)COP(=O)(O)OP(=O)(CP(=O)(O)O)O)O)O)N=C(NC2=O)N
InChI: InChI=1S/C11H18N5O13P3/c12-11-14-8-5(9(19)15-11)13-2-16(8)10-7(18)6(17)4(28-10)1-27-32(25,26)29-31(23,24)3-30(20,21)22/h2,4,6-7,10,17-18H,1,3H2,(H,23,24)(H,25,26)(H2,20,21,22)(H3,12,14,15,19)/t4-,6-,7-,10-/m1/s1



数据库引用编号

13 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome()

BioCyc()

PlantCyc()

代谢反应

个相关的代谢反应过程信息。

Reactome()

BioCyc()

WikiPathways()

Plant Reactome()

INOH()

PlantCyc()

COVID-19 Disease Map()

PathBank()

PharmGKB()

个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有:

  • PubMed: 来源于PubMed文献库中的文献信息,我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表,这个列表按照代谢物同时出现的文献数量降序排序,取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘,得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序,取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中,存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称,可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 8 CAT, CDC42, GNAQ, GTPBP4, PRKX, RAP1A, STON1-GTF2A1L, TUBB4B
Endosome membrane 1 RAP1A
Endoplasmic reticulum membrane 2 CDC42, HSP90B1
Nucleus 8 ELOF1, GNAQ, GTPBP4, HSP90B1, PLCZ1, PRKX, STON1-GTF2A1L, TUBB4B
cytosol 9 CAT, CDC42, GTPBP4, HSP90B1, NGF, PLCZ1, PRKCQ, RAP1A, TUBB4B
dendrite 1 NGF
phagocytic vesicle 1 CDC42
centrosome 1 CDC42
nucleoplasm 3 GTPBP4, PLCZ1, PRKX
Cell membrane 3 CDC42, GNAQ, RAP1A
Lipid-anchor 3 CDC42, GNAQ, RAP1A
Cytoplasmic side 1 CDC42
Multi-pass membrane protein 1 RHO
Synapse 1 GNAQ
cell junction 1 RAP1A
glutamatergic synapse 2 CDC42, RAP1A
Golgi apparatus 2 GNAQ, RHO
Golgi membrane 3 CDC42, INS, RHO
lysosomal membrane 1 GNAQ
neuronal cell body 1 CDC42
smooth endoplasmic reticulum 1 HSP90B1
synaptic vesicle 1 NGF
Presynapse 1 RAP1A
plasma membrane 6 CDC42, GCG, GNAQ, PRKCQ, RAP1A, RHO
Membrane 6 CAT, CDC42, GNAQ, GTPBP4, HSP90B1, RHO
axon 2 CCK, NGF
extracellular exosome 6 CAT, CDC42, GNAQ, HSP90B1, RAP1A, TUBB4B
endoplasmic reticulum 1 HSP90B1
extracellular space 5 CCBE1, CCK, GCG, INS, NGF
guanyl-nucleotide exchange factor complex 1 RAP1A
perinuclear region of cytoplasm 4 GTPBP4, HSP90B1, PLCZ1, RAP1A
Schaffer collateral - CA1 synapse 1 CDC42
mitochondrion 1 CAT
protein-containing complex 3 CAT, CDC42, HSP90B1
intracellular membrane-bounded organelle 1 CAT
filopodium 1 CDC42
pronucleus 1 PLCZ1
Secreted 5 CCBE1, CCK, GCG, INS, NGF
extracellular region 7 CAT, CCK, GCG, HSP90B1, INS, NGF, TUBB4B
mitochondrial matrix 1 CAT
anchoring junction 1 RAP1A
centriolar satellite 1 PRKCQ
ciliary membrane 1 RHO
photoreceptor inner segment 1 RHO
photoreceptor outer segment 2 GNAQ, RHO
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome 1 CDC42
Nucleus membrane 1 GNAQ
nuclear membrane 2 GNAQ, GTPBP4
Extracellular vesicle 1 TUBB4B
dendritic spine 1 CDC42
microtubule cytoskeleton 1 TUBB4B
nucleolus 2 GTPBP4, PLCZ1
midbody 2 CDC42, HSP90B1
Early endosome 1 RAP1A
apical part of cell 1 CDC42
cell-cell junction 2 CDC42, RHO
spindle midzone 1 CDC42
Cytoplasm, perinuclear region 2 PLCZ1, RAP1A
Cytoplasm, cytoskeleton 1 TUBB4B
Cytoplasm, cytoskeleton, spindle 1 CDC42
focal adhesion 3 CAT, CDC42, HSP90B1
microtubule 1 TUBB4B
extracellular matrix 1 CCBE1
Peroxisome 1 CAT
collagen trimer 1 CCBE1
Peroxisome matrix 1 CAT
peroxisomal matrix 1 CAT
peroxisomal membrane 1 CAT
collagen-containing extracellular matrix 1 HSP90B1
secretory granule 1 CDC42
Late endosome 1 RAP1A
neuron projection 2 CDC42, RAP1A
mitotic spindle 2 CDC42, TUBB4B
cytoskeleton 1 TUBB4B
cytoplasmic ribonucleoprotein granule 1 CDC42
Cell projection, cilium, photoreceptor outer segment 1 RHO
Nucleus, nucleolus 1 GTPBP4
sperm midpiece 2 RAP1A, RHO
intercellular bridge 1 TUBB4B
Cytoplasm, cytoskeleton, flagellum axoneme 1 TUBB4B
sperm flagellum 1 TUBB4B
Endomembrane system 1 RAP1A
endosome lumen 2 INS, NGF
axonemal microtubule 1 TUBB4B
heterotrimeric G-protein complex 1 GNAQ
leading edge membrane 1 CDC42
Cell projection, dendrite 1 CDC42
specific granule membrane 1 RAP1A
Melanosome 1 HSP90B1
Golgi-associated vesicle membrane 1 RHO
sperm plasma membrane 1 HSP90B1
ficolin-1-rich granule lumen 1 CAT
secretory granule lumen 3 CAT, GCG, INS
Golgi lumen 2 INS, NGF
endoplasmic reticulum lumen 3 GCG, HSP90B1, INS
Photoreceptor inner segment membrane 1 RHO
transport vesicle 1 INS
transcription elongation factor complex 1 ELOF1
azurophil granule lumen 1 TUBB4B
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
immunological synapse 1 PRKCQ
aggresome 1 PRKCQ
Sarcoplasmic reticulum lumen 1 HSP90B1
photoreceptor outer segment membrane 1 RHO
sperm head plasma membrane 1 RHO
photoreceptor disc membrane 1 RHO
endocytic vesicle lumen 1 HSP90B1
[Glucagon-like peptide 1]: Secreted 1 GCG
catalase complex 1 CAT
sperm head 1 PLCZ1
endoplasmic reticulum chaperone complex 1 HSP90B1
rod photoreceptor outer segment 1 RHO
transcription factor TFIIA complex 1 STON1-GTF2A1L
Golgi transport complex 1 CDC42
storage vacuole 1 CDC42


文献列表

  • Leopold Kong, Kem A Sochacki, Huaibin Wang, Shunming Fang, Bertram Canagarajah, Andrew D Kehr, William J Rice, Marie-Paule Strub, Justin W Taraska, Jenny E Hinshaw. Cryo-EM of the dynamin polymer assembled on lipid membrane. Nature. 2018 08; 560(7717):258-262. doi: 10.1038/s41586-018-0378-6. [PMID: 30069048]
  • Rahamthulla S Shaik, Min Woo Sung, Stanislav Vitha, Andreas Holzenburg. Chloroplast division protein ARC3 acts on FtsZ2 by preventing filament bundling and enhancing GTPase activity. The Biochemical journal. 2018 01; 475(1):99-115. doi: 10.1042/bcj20170697. [PMID: 29138260]
  • C Lu, H P Erickson. The straight and curved conformation of FtsZ protofilaments-evidence for rapid exchange of GTP into the curved protofilament. Cell structure and function. 1999 Oct; 24(5):285-90. doi: 10.1247/csf.24.285. [PMID: 15216884]
  • C Alegre, R Iglesias, J M Ferreras, L Citores, T Girbés. Sensitivity of ribosomes from Agrobacterium tumefaciens to the ribosome-inactivating protein crotin 2 depending on the translocational state. Cellular and molecular biology (Noisy-le-Grand, France). 1996 Mar; 42(2):151-8. doi: ". [PMID: 8696251]
  • O Fukushima, T Yamamoto, C V Gay. Ultrastructural localization of adenylate cyclase activity in chicken osteoclasts. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 1991 Sep; 39(9):1207-13. doi: 10.1177/39.9.1918938. [PMID: 1918938]
  • E Allan, A Dawson, B Drøbak, K Roberts. GTP causes calcium release from a plant microsomal fraction. Cellular signalling. 1989; 1(1):23-9. doi: 10.1016/0898-6568(89)90017-x. [PMID: 2701802]
  • J W Sherman, E J Goetzl, C H Koo. Selective modulation by guanine nucleotides of the high affinity subset of plasma membrane receptors for leukotriene B4 on human polymorphonuclear leukocytes. Journal of immunology (Baltimore, Md. : 1950). 1988 Jun; 140(11):3900-4. doi: NULL. [PMID: 2836504]
  • E A Perfilyeva, A V Skurat, M S Yurkova, Khropov YuV, T V Bulargina, E S Severin. N-Chloroacetylhydrazone of oxo-GTP irreversibly inhibits the activating function of GTP-binding protein coupled with adenylate cyclase. Biochemistry international. 1985 Jul; 11(1):1-9. doi: NULL. [PMID: 2994670]
  • M A Gray, C A Pasternak. 'Impermeant' inhibitors of protein synthesis do not affect virally-infected cells as a result of a permeability change. The Journal of antimicrobial chemotherapy. 1984 Aug; 14 Suppl A(?):107-10. doi: 10.1093/jac/14.suppl_a.107. [PMID: 6092318]
  • M A Gray, S A Austin, M J Clemens, L Rodrigues, C A Pasternak. Protein synthesis in Semliki Forest virus-infected cells is not controlled by permeability changes. The Journal of general virology. 1983 Dec; 64 ( Pt 12)(?):2631-40. doi: 10.1099/0022-1317-64-12-2631. [PMID: 6319551]


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