Histidylleucine (BioDeep_00000005704)

 

Secondary id: BioDeep_00000179781, BioDeep_00001869539

human metabolite Endogenous Volatile Flavor Compounds


代谢物信息卡片


(2S)-2-[(2S)-2-amino-3-(1H-imidazol-4-yl)propanamido]-4-methylpentanoic acid

化学式: C12H20N4O3 (268.15353300000004)
中文名称: L-组氨酰-L-亮氨酸
谱图信息: 最多检出来源 Homo sapiens(feces) 92.48%

分子结构信息

SMILES: CC(C)CC(C(=O)O)NC(=O)C(CC1=CN=CN1)N
InChI: InChI=1S/C12H20N4O3/c1-7(2)3-10(12(18)19)16-11(17)9(13)4-8-5-14-6-15-8/h5-7,9-10H,3-4,13H2,1-2H3,(H,14,15)(H,16,17)(H,18,19)

描述信息

Histidylleucine is a dipeptide composed of histidine and leucine. It is an incomplete breakdown product of protein digestion or protein catabolism. Dipeptides are organic compounds containing a sequence of exactly two alpha-amino acids joined by a peptide bond. Some dipeptides are known to have physiological or cell-signalling effects although most are simply short-lived intermediates on their way to specific amino acid degradation pathways following further proteolysis.

同义名列表

22 个代谢物同义名

(2S)-2-[(2S)-2-amino-3-(1H-imidazol-4-yl)propanamido]-4-methylpentanoic acid; Histidine leucine dipeptide; Histidine-leucine dipeptide; N-L-Histidinyl-L-leucine; N-L-Histidyl-L-leucine; L-Histidinyl-L-leucine; N-L-Histidyl-L-leucin; L-Histidyl-L-leucine; N-Histidinylleucine; Histidinyl-Leucine; N-Histidylleucine; Histidinylleucine; Histidyl-leucine; Histidylleucine; H-L Dipeptide; H-His-Leu-OH; HL Dipeptide; L-His-L-leu; His-leu; H-L; HL; Histidylleucine



数据库引用编号

15 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。



文献列表

  • Adrian Drapała, Klaudia Bielińska, Piotr Konopelski, Leszek Pączek, Marcin Ufnal. His-Leu, an angiotensin I-derived peptide, does not affect haemodynamics in rats. Journal of the renin-angiotensin-aldosterone system : JRAAS. 2018 Oct; 19(4):1470320318808879. doi: 10.1177/1470320318808879. [PMID: 30370829]
  • Noorlidah Abdullah, Siti Marjiana Ismail, Norhaniza Aminudin, Adawiyah Suriza Shuib, Beng Fye Lau. Evaluation of Selected Culinary-Medicinal Mushrooms for Antioxidant and ACE Inhibitory Activities. Evidence-based complementary and alternative medicine : eCAM. 2012; 2012(?):464238. doi: 10.1155/2012/464238. [PMID: 21716693]
  • See-Ziau Hoe, Mohd Yusof Kamaruddin, Sau-Kuen Lam. Inhibition of angiotensin-converting enzyme activity by a partially purified fraction of Gynura procumbens in spontaneously hypertensive rats. Medical principles and practice : international journal of the Kuwait University, Health Science Centre. 2007; 16(3):203-8. doi: 10.1159/000100391. [PMID: 17409755]
  • K Sakata, T Yamashita, M Maeda, Y Moriyama, S Shimada, M Tohyama. Cloning of a lymphatic peptide/histidine transporter. The Biochemical journal. 2001 May; 356(Pt 1):53-60. doi: 10.1042/0264-6021:3560053. [PMID: 11336635]
  • R Reneland, H Lithell. Angiotensin-converting enzyme in human skeletal muscle. A simple in vitro assay of activity in needle biopsy specimens. Scandinavian journal of clinical and laboratory investigation. 1994 Apr; 54(2):105-11. doi: 10.3109/00365519409086516. [PMID: 8197396]
  • H Iwata, K Saito, S Furusaki, T Sugo, J Okamoto. Adsorption characteristics of an immobilized metal affinity membrane. Biotechnology progress. 1991 Sep; 7(5):412-8. doi: 10.1021/bp00011a005. [PMID: 1367992]
  • A C Shisheva, T Dimitrov, O C Ikonomov. Plasma angiotensin-converting enzyme activity and blood pressure during the first year of life in normotensive and spontaneously hypertensive rat. Acta physiologica Hungarica. 1991; 77(2):129-38. doi: . [PMID: 1656699]
  • R A Santos, E M Krieger, L J Greene. An improved fluorometric assay of rat serum and plasma converting enzyme. Hypertension (Dallas, Tex. : 1979). 1985 Mar; 7(2):244-52. doi: 10.1161/01.hyp.7.2.244. [PMID: 2984118]
  • N Loreau, C Lepreux, R Ardaillou. Calcitonin-sensitive adenylate cyclase in rat renal tubular membranes. The Biochemical journal. 1975 Sep; 150(3):305-14. doi: 10.1042/bj1500305. [PMID: 2153]