Barbituric acid (BioDeep_00000004486)
Secondary id: BioDeep_00001868375
human metabolite Endogenous
代谢物信息卡片
2,4,6(1H,3H,5H)-Pyrimidinetrione (acd/name 4.0)
化学式: C4H4N2O3 (128.0222)
中文名称: 巴比妥酸
谱图信息:
最多检出来源 Homo sapiens(plant) 9.57%
分子结构信息
SMILES: C1C(=O)NC(=O)NC1=O
InChI: InChI=1S/C4H4N2O3/c7-2-1-3(8)6-4(9)5-2/h1H2,(H2,5,6,7,8,9)
描述信息
Barbituric acid or malonylurea or 6-hydroxyuracil is an organic compound based on a pyrimidine heterocyclic skeleton. It is an odorless powder soluble in water. Barbituric acid is the parent compound of barbiturate drugs, although barbituric acid itself is not pharmacologically active. The compound was discovered by the German chemist Adolf von Baeyer on December 4, 1864, the feast of Saint Barbara (who gave the compound its namesake), by combining urea and malonic acid in a condensation reaction. Malonic acid has since been replaced by diethyl malonate, as using the ester avoids the problem of having to deal with the acidity of the carboxylic acid and its unreactive carboxylate.
同义名列表
25 个代谢物同义名
2,4,6(1H,3H,5H)-Pyrimidinetrione (acd/name 4.0); 4,6-dihydroxy-2,5-dihydropyrimidin-2-one; N,N-(1,3-dioxo-1,3-propanediyl)-urea; NN-(1,3-Dioxo-1,3-propanediyl)-urea; 2,4,6-(1H,3H,5H)-Pyrimidinetrione; Pyrimidine-2,4,6(1H,3H,5H)-trione; 2,4,6(1H,3H,5H)-Pyrimidinetrione; 2,4,6-Pyrimidinetrione(1H,3H,5H); Barbituric acid, monosodium salt; 2,4,6-Trioxohexahydropyrimidine; 2,4,6-Trihydroxypyrimidine; 2,4,6-Pyrimidinetriol; sodium barbiturate; Pyrimidinetrione; Malonylharnstoff; BARBITURIC ACID; 6-HYDROXYURACIL; Barbitursaeure; Barbitursaure; Barbitic acid; Barbiturate; Malonylurea; Barbitate; Barbiturate; Barbituric acid
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:16294
- KEGG: C00813
- PubChem: 6211
- HMDB: HMDB0041833
- Metlin: METLIN63410
- Wikipedia: Barbituric_acid
- chemspider: 5976
- CAS: 67-52-7
- PMhub: MS000016976
- PubChem: 4071
- PDB-CCD: BR8
- 3DMET: B01336
- NIKKAJI: J348D
- RefMet: Barbituric acid
- KNApSAcK: 16294
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Seon-Mi Seo, Hyo-Rim Lee, Ji-Eun Lee, Yong-Chul Jeong, Hyung-Wook Kwon, Joon-Kwan Moon, Mark G Moloney, Il-Kwon Park. Larvicidal and Nematicidal Activities of 3-Acylbarbituric Acid Analogues against Asian Tiger Mosquito, Aedes albopictus, and Pine Wood Nematode, Bursaphelenchus xylophilus.
Molecules (Basel, Switzerland).
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Bibliotheca haematologica.
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10.1159/000426527. [PMID: 14266980] - E S FURANO, N M GREENE. METABOLIC BREAKDOWN OF THIOPENTAL IN MAN DETERMINED BY GAS CHROMATOGRAPHIC ANALYSIS OF SERUM BARBITURATE LEVELS.
Anesthesiology.
1963 Nov; 24(?):796-800. doi:
10.1097/00000542-196311000-00008. [PMID: 14071411] - W E GOLDHAHN, P OTTO. [ON THE EXTRACORPOREAL HEMODIALYSIS OF BARBITURIC ACIDS].
Arzneimittel-Forschung.
1963 Nov; 13(?):977-80. doi:
NULL. [PMID: 14210437] - B KUHLBAECK, L G TALLGREN, A PASTERNACK. [INDICATIONS FOR TREATMENT WITH ARTIFICIAL KIDNEY].
Suomen laakarilehti. Finlands lakartidning.
1963 Oct; 18(?):1749-56. doi:
NULL. [PMID: 14057398] - T BERITIC. [ACUTE POISONING WITH HYPNOTICS AND SEDATIVES].
Lijecnicki vjesnik.
1963 Oct; 85(?):1131-9. doi:
NULL. [PMID: 14097617] - A MYSCHETZKY, N A LASSEN. UREA-INDUCED, OSMOTIC DIURESIS AND ALKALIZATION OF URINE IN ACUTE BARBITURATE INTOXICATION.
JAMA.
1963 Sep; 185(?):936-42. doi:
10.1001/jama.1963.03060120046020. [PMID: 14044226] - O L RAIAVEE, L B NURMAND. [ON FUNCTIONAL ELIMINATION AND TOXICITY OF BARBAMYL AND PENTOTHAL SODIUM IN HYPOTHERMIA].
Farmakologiia i toksikologiia.
1963 Sep; 26(?):556-9. doi:
NULL. [PMID: 14123752] - R GUZAK, W T CARAWAY. SIMULTANEOUS DETERMINATION OF SERUM BARBITURATE AND SALICYLATE BY ULTRAVIOLET ABSORPTION SPECTROPHOTOMETRY.
The American journal of medical technology.
1963 Jul; 29(?):231-9. doi:
NULL. [PMID: 14046025] - A MYSCHETZKY, N A LASSEN. Osmotic diuresis and alkalinization of the urine in the treatment of severe acute barbiturate intoxication.
Danish medical bulletin.
1963 Jun; 10(?):104-8. doi:
NULL. [PMID: 13936995] - G WALLENIUS, B ZAAR, E LAUSING. A rapid method for determination of barbiturate in serum or urine.
Scandinavian journal of clinical and laboratory investigation.
1963; 15 Suppl 69(?):252-6. doi:
NULL. [PMID: 13998586] - H RYMKIEWICZ. [EXTRARENAL INDICATIONS FOR EXTRACORPOREAL DIALYSIS].
Polskie Archiwum Medycyny Wewnetrznej.
1963; 33(?):825-7. doi:
NULL. [PMID: 14058643] - G SCHMIDT. [Problems of forensic importance in barbiturate excretion in the urine].
Arzneimittel-Forschung.
1962 Nov; 12(?):1081-5. doi:
NULL. [PMID: 13991988] - W F STRAUSS, R K MEYER. Neural timing of ovulation in immature rats treated with gonadotrophin.
Science (New York, N.Y.).
1962 Sep; 137(3533):860-1. doi:
10.1126/science.137.3533.860. [PMID: 13917713] - L ANDREOTTI, E GUARNIERI, M PALAZZUOLI. [Influence of the nervous system on the blood lipids: changes in various blood lipid fractions after electroshock and after barbiturate anesthesia].
Rassegna di neurologia vegetativa.
1962 Jun; 16(?):204-25. doi:
". [PMID: 14013040] - B BOBRANSKI, M KONIECZNY, L SYPER. INVESTIGATIONS ON THE MECHANISM OF THE DEGRADATION OF 5-ALLYL-5-(BETA-HYDROXYPROPYL)-BARBITURIC ACID IN THE ORGANISM. METABOLISM OF 1-METHYL-5-ALLYL-5-(BETA-HYDROXYPROPYL)-BARBITURIC ACIDS IN THE ORGANISM OF RABBITS.
Archivum immunologiae et therapiae experimentalis.
1962; 10(?):811-7. doi:
NULL. [PMID: 14054135] - K FOERSTER. [Effect of barbituric acid derivatives on the development of plant roots and root hairs].
Acta biologica et medica Germanica.
1962; 9(?):497-516. doi:
". [PMID: 13945700] - R C BALAGOT, H TSUJI, M S SADOVE. Use of an osmotic diuretic-THAM-in treatment of barbiturate poisoning. Alkalinizing action of drug and its ability to increase elimination of electrolytes in urine appears to facilitate clearance of barbiturates.
JAMA.
1961 Dec; 178(?):1000-4. doi:
10.1001/jama.1961.03040490026006. [PMID: 13864230] - G ADEBAHR. [The kidney in cerebral injuries caused by barbiturate poisoning and cranial injuries].
Archiv fur Toxikologie.
1961; 19(?):169-95. doi:
NULL. [PMID: 13859383] - F GIARDINI, V M VENUTI. [Influence of barbiturate anesthesia on the mineralotropic function of the adrenal cortex].
Archivio di medicina interna.
1959 Aug; 11(?):167-70. doi:
NULL. [PMID: 13827873] - P O KANE, S E SMITH. Thiopentone and buthalitone: the relationship between depth of anaesthesia, plasma concentration and plasma protein binding.
British journal of pharmacology and chemotherapy.
1959 Jun; 14(2):261-4. doi:
10.1111/j.1476-5381.1959.tb01396.x. [PMID: 13662586] - J LANDMANN, R M RIBEIRO, Y BEDRAN, T VIANNA, A GENTILE. [Treatment of acute barbiturate poisoning: dialysis by artificial kidney].
Medicina, cirurgia, farmacia.
1959 Apr; 21(276):121-32. doi:
NULL. [PMID: 13656094] - G REISSLAND. [Barbiturate poisoning appearing as hepatorenal syndrome].
Medizinische Klinik.
1959 Feb; 54(7):268-9. doi:
NULL. [PMID: 13643564] - H FAHLGREN, R HED, R ORDELL. Studies on serum transaminase activity in barbiturate intoxication.
Acta medica Scandinavica.
1958 Mar; 160(3):215-9. doi:
10.1111/j.0954-6820.1958.tb10344.x. [PMID: 13532500] - G TONI. [Effect of barbiturate anesthesia on urinary excretion of C21-alpha-ketols].
Rivista di patologia e clinica.
1958 Mar; 13(3):115-7. doi:
NULL. [PMID: 13555602] - T K WITH. Porphyrin metabolism and barbiturate poisoning: observations on cases of acute and chronic poisoning.
Journal of clinical pathology.
1957 May; 10(2):165-7. doi:
10.1136/jcp.10.2.165. [PMID: 13428875] - G PAERREGAARD. [Renal function in acute barbituric acid poisoning, as determined by creatinine clearance].
Ugeskrift for laeger.
1956 Jul; 118(27):778. doi:
NULL. [PMID: 13352542] - E BRODWALL, K F STOA. A study of barbiturate clearance.
Acta medica Scandinavica.
1956 Mar; 154(2):139-44. doi:
10.1111/j.0954-6820.1956.tb14307.x. [PMID: 13313076] - P LOUS. Plasma levels and urinary excretion of three barbituric acids after oral administration to man.
Acta pharmacologica et toxicologica.
1954; 10(2):147-65. doi:
10.1111/j.1600-0773.1954.tb01332.x. [PMID: 14349708] - P LOUS. Barbituric acid concentration in serum from patients with severe acute poisoning.
Acta pharmacologica et toxicologica.
1954; 10(3):261-80. doi:
10.1111/j.1600-0773.1954.tb01343.x. [PMID: 14349719] - P LOUS. A spectrophotometric method for determining barbituric acids in body fluids.
Acta pharmacologica et toxicologica.
1954; 10(2):134-46. doi:
10.1111/j.1600-0773.1954.tb01331.x. [PMID: 14349707] - A MANZINI, P ZOBOLI. Effect of hemihepatectomy on barbiturate sensitivity of phosphatase.
Archives internationales de pharmacodynamie et de therapie.
1953 Aug; 94(4):465-9. doi:
NULL. [PMID: 13114943] - A BER. [Studies on auxin effects. I. Effect of barbituric acid derivatives on the growth of plants].
Endokrinologie.
1953 Apr; 30(1-2):54-9. doi:
". [PMID: 13083605]
