6-Chloro-1,3,5-triazine-2,4-diamine (BioDeep_00000003291)
Secondary id: BioDeep_00001868727
human metabolite blood metabolite
代谢物信息卡片
化学式: C3H4ClN5 (145.0155)
中文名称: 2-氯-4,6-二氨-1,3,5-三嗪, 6-氯-1,3,5-三嗪-2,4-二胺
谱图信息:
最多检出来源 Homo sapiens(blood) 30.63%
分子结构信息
SMILES: C1(=NC(=NC(=N1)Cl)N)N
InChI: InChI=1S/C3H4ClN5/c4-1-7-2(5)9-3(6)8-1/h(H4,5,6,7,8,9)
描述信息
CONFIDENCE standard compound; INTERNAL_ID 2022
同义名列表
12 个代谢物同义名
6-chloro-1,2,3,4-tetrahydro-1,3,5-triazine-2,4-diimine; 6-Chloro-1,3,5-triazine-2,4-diamine; 2,4-Diamino-6-chloro-1,3,5-triazine; 2-Chloro-4,6-diamino-S-triazine; 2,4-Diamino-6-chloro-S-triazine; desethyl-desisopropyl-atrazine; 2-Chloro-4,6-diaminotriazine; Deisopropyldeethylatrazine; Deethyldeisopropylatrazine; 2-CAAT; Deisopropyldeethylatrazine; 6-Chloro-1,3,5-triazine-2,4-diamine
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:27726
- KEGG: C06560
- PubChem: 18831
- HMDB: HMDB0246174
- Metlin: METLIN66435
- ChEMBL: CHEMBL1872965
- chemspider: 17781
- CAS: 3397-62-4
- MoNA: AU202201
- PMhub: MS000008726
- PubChem: 8789
- 3DMET: B00972
- NIKKAJI: J80.717F
- KNApSAcK: 27726
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Michelle Gatien Hotchkiss, Deborah S Best, Ralph L Cooper, Susan C Laws. Atrazine does not induce pica behavior at doses that increase hypothalamic-pituitary-adrenal axis activation and cause conditioned taste avoidance.
Neurotoxicology and teratology.
2012 May; 34(3):295-302. doi:
10.1016/j.ntt.2012.03.001. [PMID: 22430068] - Sara C Novais, Wim De Coen, Mónica J B Amorim. Gene expression responses linked to reproduction effect concentrations (EC 10,20,50,90) of dimethoate, atrazine and carbendazim, in Enchytraeus albidus.
PloS one.
2012; 7(4):e36068. doi:
10.1371/journal.pone.0036068. [PMID: 22558331] - Hongtao Lei, Yudong Shen, Lijun Song, Jinyi Yang, Olivier P Chevallier, Simon A Haughey, Hong Wang, Yuanming Sun, Christopher T Elliott. Hapten synthesis and antibody production for the development of a melamine immunoassay.
Analytica chimica acta.
2010 Apr; 665(1):84-90. doi:
10.1016/j.aca.2010.03.007. [PMID: 20381695] - Susan C Laws, Michelle Hotchkiss, Janet Ferrell, Saro Jayaraman, Lesley Mills, Walker Modic, Nicole Tinfo, Melanie Fraites, Tammy Stoker, Ralph Cooper. Chlorotriazine herbicides and metabolites activate an ACTH-dependent release of corticosterone in male Wistar rats.
Toxicological sciences : an official journal of the Society of Toxicology.
2009 Nov; 112(1):78-87. doi:
10.1093/toxsci/kfp190. [PMID: 19690231] - Melanie J P Fraites, Ralph L Cooper, Angela Buckalew, Saro Jayaraman, Lesley Mills, Susan C Laws. Characterization of the hypothalamic-pituitary-adrenal axis response to atrazine and metabolites in the female rat.
Toxicological sciences : an official journal of the Society of Toxicology.
2009 Nov; 112(1):88-99. doi:
10.1093/toxsci/kfp194. [PMID: 19710361] - Tami S McMullin, William H Hanneman, Brian K Cranmer, John D Tessari, Melvin E Andersen. Oral absorption and oxidative metabolism of atrazine in rats evaluated by physiological modeling approaches.
Toxicology.
2007 Oct; 240(1-2):1-14. doi:
10.1016/j.tox.2007.05.031. [PMID: 17767989] - Dana B Barr, Parinya Panuwet, Johnny V Nguyen, Simeon Udunka, Larry L Needham. Assessing exposure to atrazine and its metabolites using biomonitoring.
Environmental health perspectives.
2007 Oct; 115(10):1474-8. doi:
10.1289/ehp.10141. [PMID: 17938738] - Greg P Dooley, William H Hanneman, David L Carbone, Marie E Legare, Melvin E Andersen, John D Tessari. Development of an immunochemical detection method for atrazine-induced albumin adducts.
Chemical research in toxicology.
2007 Jul; 20(7):1061-6. doi:
10.1021/tx700083v. [PMID: 17567052] - Markus Hecker, John P Giesy, Paul D Jones, Alarik M Jooste, James A Carr, Keith R Solomon, Ernest E Smith, Glen Van der Kraak, Ronald J Kendall, Louis Du Preez. Plasma sex steroid concentrations and gonadal aromatase activities in African clawed frogs (Xenopus laevis) from South Africa.
Environmental toxicology and chemistry.
2004 Aug; 23(8):1996-2007. doi:
10.1897/03-450. [PMID: 15352490] - Tami S McMullin, Melvin E Andersen, Alan Nagahara, Trent D Lund, Toni Pak, Robert J Handa, William H Hanneman. Evidence that atrazine and diaminochlorotriazine inhibit the estrogen/progesterone induced surge of luteinizing hormone in female Sprague-Dawley rats without changing estrogen receptor action.
Toxicological sciences : an official journal of the Society of Toxicology.
2004 Jun; 79(2):278-86. doi:
10.1093/toxsci/kfh127. [PMID: 15056801] - Jill M Brzezicki, Melvin E Andersen, Brian K Cranmer, John D Tessari. Quantitative identification of atrazine and its chlorinated metabolites in plasma.
Journal of analytical toxicology.
2003 Nov; 27(8):569-73. doi:
10.1093/jat/27.8.569. [PMID: 14670135] - Tami S McMullin, Jill M Brzezicki, Brian K Cranmer, John D Tessari, Melvin E Andersen. Pharmacokinetic modeling of disposition and time-course studies with [14C]atrazine.
Journal of toxicology and environmental health. Part A.
2003 May; 66(10):941-64. doi:
10.1080/15287390306454. [PMID: 12825238] - Joseane M Pozzebon, Wagner Vilegas, Isabel C S F Jardim. Determination of herbicides and a metabolite in human urine by liquid chromatography-electrospray ionization mass spectrometry.
Journal of chromatography. A.
2003 Feb; 987(1-2):375-80. doi:
10.1016/s0021-9673(02)01950-7. [PMID: 12613831] - Hiroyoshi Omokawa, Akiko Tabei. Enantioselective effects of optically active alpha-methylbenzyl-s-triazine on the root growth of rice and Echinochloa plants and their herbicidal activity.
Bioscience, biotechnology, and biochemistry.
2002 Sep; 66(9):1959-62. doi:
10.1271/bbb.66.1959. [PMID: 12400699] - Tammy E Stoker, D L Guidici, S C Laws, R L Cooper. The effects of atrazine metabolites on puberty and thyroid function in the male Wistar rat.
Toxicological sciences : an official journal of the Society of Toxicology.
2002 Jun; 67(2):198-206. doi:
10.1093/toxsci/67.2.198. [PMID: 12011479]
