Nicorandil (BioDeep_00000003156)
Secondary id: BioDeep_00000399009
human metabolite blood metabolite
代谢物信息卡片
N-(2-Hydroxyethyl)nicotinamide nitric acid
化学式: C8H9N3O4 (211.0593)
中文名称: 尼可地尔
谱图信息:
最多检出来源 Rattus norvegicus(blood) 47.98%
分子结构信息
SMILES: C1=CC(=CN=C1)C(=O)NCCO[N+](=O)[O-]
InChI: InChI=1S/C8H9N3O4/c12-8(7-2-1-3-9-6-7)10-4-5-15-11(13)14/h1-3,6H,4-5H2,(H,10,12)
描述信息
C - Cardiovascular system > C01 - Cardiac therapy > C01D - Vasodilators used in cardiac diseases
COVID info from clinicaltrial, clinicaltrials, clinical trial, clinical trials
C78274 - Agent Affecting Cardiovascular System > C29707 - Vasodilating Agent
D002317 - Cardiovascular Agents > D000959 - Antihypertensive Agents
D002317 - Cardiovascular Agents > D000889 - Anti-Arrhythmia Agents
D002317 - Cardiovascular Agents > D014665 - Vasodilator Agents
D018977 - Micronutrients > D014815 - Vitamins
Same as: D01810
Corona-virus
Coronavirus
SARS-CoV-2
COVID-19
SARS-CoV
COVID19
SARS2
SARS
同义名列表
28 个代谢物同义名
N-(2-Hydroxyethyl)nicotinamide nitric acid; 2-[(pyridin-3-yl)formamido]ethyl nitrate; Rhône-poulenc rorer brand OF nicorandil; Rhône poulenc rorer brand OF nicorandil; N-(2-Hydroxyethyl)nicotinamide nitrate; Merck lipha santé brand OF nicorandil; Aventis pharma brand OF nicorandil; 2-Nicotinamidoethyl nitric acid; Nitrate, 2-nicotinamidoethyl; Aventis brand OF nicorandil; 2 Nicotinamidoethyl nitrate; Nitrate, 2-nicotinamidethyl; 2-Nicotinamidoethyl nitrate; 2-Nicotinamidethyl nitrate; 2 Nicotinamidethyl nitrate; Merck brand OF nicorandil; Nicorandil aventis brand; Nicorandil merck brand; Nicorandilum; NICORANDIL; Perisalol; Adancor; Sigmart; Dancor; Ikorel; SG-75; SG 75; Nicorandil
数据库引用编号
15 个数据库交叉引用编号
- ChEBI: CHEBI:31905
- KEGG: C13280
- PubChem: 47528
- HMDB: HMDB0255584
- Metlin: METLIN1521
- DrugBank: DB09220
- ChEMBL: CHEMBL284906
- Wikipedia: Nicorandil
- MeSH: Nicorandil
- CAS: 65141-46-0
- PMhub: MS000008307
- PubChem: 586024
- NIKKAJI: J4.534I
- RefMet: Nicorandil
- KNApSAcK: 31905
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
1 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Asser F Bedair, Ahmed Wahid, Nesrine S El-Mezayen, Amira F El-Yazbi, Hadeel A Khalil, Nayera W Hassan, Elham A Afify. Nicorandil/ morphine crosstalk accounts for antinociception and hepatoprotection in hepatic fibrosis in rats: Distinct roles of opioid/cGMP and NO/KATP pathways.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2023 Jun; 165(?):115068. doi:
10.1016/j.biopha.2023.115068. [PMID: 37392650] - Yanda Zhang, Jian Zhao, Changzhen Ren, Bowen Hu, Ru Ding, Zhiqing He, Chun Liang. Free fatty acids induce coronary microvascular dysfunction via inhibition of the AMPK/KLF2/eNOS signaling pathway.
International journal of molecular medicine.
2023 04; 51(4):. doi:
10.3892/ijmm.2023.5237. [PMID: 36928181] - Nitin Sharma, Anjana Sharma, Yogesh Rai, Ritu Karwasra, Kushagra Khanna, Dhruv Kumar Nishad, Anant Narayan Bhatt, Aseem Bhatnagar, Dipti Kakkar. Protective Effect of Organ Preservation Fluid Supplemented With Nicorandil and Rutin Trihydrate: A Comparative Study in a Rat Model of Renal Ischemia.
Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation.
2022 06; 20(6):569-579. doi:
10.6002/ect.2022.0019. [PMID: 35791830] - Xiaozhi Du, Zhiyong Ma, Li Li, Xuezhen Zhong. Nicorandil Decreases Renal Injury in Patients With Coronary Heart Disease Complicated With Type I Cardiorenal Syndrome.
Journal of cardiovascular pharmacology.
2021 09; 78(5):e675-e680. doi:
10.1097/fjc.0000000000001117. [PMID: 34738551] - Anahid Safari, Vicenzo Lionetti, Iman Razeghian-Jahromi. Combination of mesenchymal stem cells and nicorandil: an emerging therapeutic challenge against COVID-19 infection-induced multiple organ dysfunction.
Stem cell research & therapy.
2021 07; 12(1):404. doi:
10.1186/s13287-021-02482-8. [PMID: 34266486] - Ambudhar Sharma, Charu Sharma, Sujeet Raina, Balraj Singh, Devendra Singh Dadhwal, Vinay Dogra, Swatantra Gupta, Shyam Bhandari, Vivek Sood. A randomized open-label trial to evaluate the efficacy and safety of triple therapy with aspirin, atorvastatin, and nicorandil in hospitalised patients with SARS Cov-2 infection: A structured summary of a study protocol for a randomized controlled trial.
Trials.
2021 Jul; 22(1):451. doi:
10.1186/s13063-021-05361-y. [PMID: 34266452] - Sarai Sánchez-Duarte, Sergio Márquez-Gamiño, Rocío Montoya-Pérez, Erick Andrés Villicaña-Gómez, Karla Susana Vera-Delgado, Cipriana Caudillo-Cisneros, Fernando Sotelo-Barroso, Ma Teresa Melchor-Moreno, Elizabeth Sánchez-Duarte. Nicorandil decreases oxidative stress in slow- and fast-twitch muscle fibers of diabetic rats by improving the glutathione system functioning.
Journal of diabetes investigation.
2021 Jul; 12(7):1152-1161. doi:
10.1111/jdi.13513. [PMID: 33503290] - Tajamul H Mir, Parvaiz A Zargar, Bushra Jabeen, Aariba Zahoor. Nicorandil a magic bullet or a double edged sword in critically ill COVID-19 patients?.
Clinical and experimental pharmacology & physiology.
2021 06; 48(6):938-939. doi:
10.1111/1440-1681.13487. [PMID: 33684970] - Qi Huang, Wen Ting Wang, Shi Sheng Wang, De An Pei, Xiang Qian Sui. Cardiovascular magnetic resonance image analysis and mechanism study for the changes after treatments for primary microvascular angina pectoris.
Medicine.
2021 May; 100(21):e26038. doi:
10.1097/md.0000000000026038. [PMID: 34032727] - Zhican Zeng, Hong Zhang, Peng Zhang, Ying Li, Naikuan Fu. Standard vs. double dose of intravenous nicorandil in preventing contrast-induced nephropathy in patients with coronary heart disease undergoing elective coronary procedures.
Coronary artery disease.
2021 May; 32(3):256-257. doi:
10.1097/mca.0000000000000927. [PMID: 32694361] - Zhongwei Liu, Haitao Zhu, Chunhui He, Ting He, Shuo Pan, Na Zhao, Ling Zhu, Gongchang Guan, Peng Liu, Yong Zhang, Junkui Wang. Nicorandil attenuates high glucose-induced insulin resistance by suppressing oxidative stress-mediated ER stress PERK signaling pathway.
BMJ open diabetes research & care.
2021 04; 9(1):. doi:
10.1136/bmjdrc-2020-001884. [PMID: 33888540] - Dalia M Ezzat, Asmaa M Soliman, Dalia H El-Kashef. Nicorandil mitigates folic acid-induced nephrotoxicity in mice: Role of iNOS and eNOS.
Journal of biochemical and molecular toxicology.
2021 Apr; 35(4):e22692. doi:
10.1002/jbt.22692. [PMID: 33404076] - Inas A Harb, Hend Ashour, Dina Sabry, Dina Fawzy El-Yasergy, Wael Mostafa Hamza, Abeer Mostafa. Nicorandil prevents the nephrotoxic effect of cyclosporine-A in albino rats through modulation of HIF-1α/VEGF/eNOS signaling.
Canadian journal of physiology and pharmacology.
2021 Apr; 99(4):411-417. doi:
10.1139/cjpp-2020-0012. [PMID: 32822562] - Jinshuai Lu, Fen Liu, Xia Yu, Likun Xu, Lingling Zhang. The Anti-Inflammatory and Antiapoptotic Effects of Nicorandil in Antisepsis Cardiomyopathy.
Cardiovascular therapeutics.
2021; 2021(?):5822920. doi:
10.1155/2021/5822920. [PMID: 34950238] - Asmaa Ramadan Abdel-Sattar, Ali Ahmed Abo-Saif, Amira M Aboyoussef. Nicorandil and atorvastatin attenuate carbon tetrachloride - induced liver fibrosis in rats.
Immunopharmacology and immunotoxicology.
2020 Dec; 42(6):582-593. doi:
10.1080/08923973.2020.1830104. [PMID: 32988255] - Hend Ashour, Mohamed H Elsayed, Soha Elmorsy, Inas A Harb. Hypothesis: The potential therapeutic role of nicorandil in COVID-19.
Clinical and experimental pharmacology & physiology.
2020 11; 47(11):1791-1797. doi:
10.1111/1440-1681.13395. [PMID: 32881062] - Yasir Abdul Ghaffar, Ramesh Daggubati. Nicorandil for CIN Prevention - A Hope or Hype?.
Cardiovascular revascularization medicine : including molecular interventions.
2020 09; 21(9):1128-1130. doi:
10.1016/j.carrev.2020.07.006. [PMID: 32684440] - Raymond Pranata, Rachel Vania, Amir Aziz Alkatiri, Doni Firman, Antonia Anna Lukito. Nicorandil Reduces the Incidence of Contrast-Induced Nephropathy in Patients Undergoing Coronary Angiography/Intervention - Systematic Review and Meta-Analysis of Randomized Controlled Trials Including GRADE Qualification.
Cardiovascular revascularization medicine : including molecular interventions.
2020 09; 21(9):1121-1127. doi:
10.1016/j.carrev.2020.01.010. [PMID: 31959562] - E Sánchez-Duarte, C Cortés-Rojo, L A Sánchez-Briones, J Campos-García, A Saavedra-Molina, I Delgado-Enciso, U A López-Lemus, R Montoya-Pérez. Nicorandil Affects Mitochondrial Respiratory Chain Function by Increasing Complex III Activity and ROS Production in Skeletal Muscle Mitochondria.
The Journal of membrane biology.
2020 08; 253(4):309-318. doi:
10.1007/s00232-020-00129-y. [PMID: 32620983] - Anna Toso, Mario Leoncini, Mauro Maioli, Francesco Bellandi. Pharmacologic Prophylaxis of Contrast-Induced Nephropathy.
Interventional cardiology clinics.
2020 07; 9(3):369-383. doi:
10.1016/j.iccl.2020.02.006. [PMID: 32471677] - Biming Zhan, Zongyu Xu, Yang Zhang, Kefei Wan, Hanyue Deng, Dimeng Wang, Huihui Bao, Qinghua Wu, Xiaohong Hu, Hong Wang, Xiao Huang, Xiaoshu Cheng. Nicorandil reversed homocysteine-induced coronary microvascular dysfunction via regulating PI3K/Akt/eNOS pathway.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2020 Jul; 127(?):110121. doi:
10.1016/j.biopha.2020.110121. [PMID: 32407984] - Jinfan Tian, Lijun Zhang, Xueyao Yang, Huijuan Zuo, Xin Zhao, Jingwen Yong, Yi He, Xiantao Song. The effect of Shexiang Tongxin Dropping Pills on coronary microvascular dysfunction (CMVD) among those with a mental disorder and non-obstructive coronary artery disease based on stress cardiac magnetic resonance images: A study protocol.
Medicine.
2020 May; 99(21):e20099. doi:
10.1097/md.0000000000020099. [PMID: 32481277] - Xue Zhang, Shicheng Yang, Peng Zhang, Naikuan Fu. Efficacy of nicorandil on the prevention of contrast-induced nephropathy in patients with coronary heart disease undergoing percutaneous coronary intervention.
Coronary artery disease.
2020 05; 31(3):284-288. doi:
10.1097/mca.0000000000000826. [PMID: 31658134] - Peng Zhang, Wen-Yuan Li, Shi-Cheng Yang, Nai-Kuan Fu, Xiao-Gang Liu, Xue Zhang, Hong-Liang Cong, Wen-Hua Lin, Feng-Shi Tian, Cheng-Zhi Lu, Jing Zhang. Preventive Effects of Nicorandil Against Contrast-Induced Nephropathy in Patients With Moderate Renal Insufficiency Undergoing Percutaneous Coronary Intervention.
Angiology.
2020 02; 71(2):183-188. doi:
10.1177/0003319719841733. [PMID: 30987432] - Houyong Zhu, Xiaoqun Xu, Xiaojiang Fang, Jianwu Zheng, Qian Zhao, Tielong Chen, Jinyu Huang. Response to Letter Regarding Article, "Effects of the Antianginal Drugs Ranolazine, Nicorandil and Ivabradine on Coronary Microvascular Function in Patients with Non-obstructive Coronary Artery Disease: A Meta-analysis of Randomized Controlled Trials".
Clinical therapeutics.
2020 02; 42(2):376-377. doi:
10.1016/j.clinthera.2019.12.016. [PMID: 31973937] - Ke Ning, Li Jiang, Ting Hu, Xingyu Wang, Aihua Liu, Yimin Bao. ATP-Sensitive Potassium Channels Mediate the Cardioprotective Effect of Panax notoginseng Saponins against Myocardial Ischaemia-Reperfusion Injury and Inflammatory Reaction.
BioMed research international.
2020; 2020(?):3039184. doi:
10.1155/2020/3039184. [PMID: 33134375] - Bin Yi, Shaoyan Mo, Yumei Jiang, Dingwu Yi, Jinwen Luo, Xiang Chen, Jian Rong. Efficacy and Safety of Nicorandil in Preventing Contrast-Induced Nephropathy after Elective Percutaneous Coronary Intervention: A Pooled Analysis of 1229 Patients.
Journal of interventional cardiology.
2020; 2020(?):4527816. doi:
10.1155/2020/4527816. [PMID: 32982608] - Abdelaziz M Hussein, Mohamed Eldosoky, Hala Abdel Malek, Mohamed Elshafey, Eman El Nashar, Gamal Dahab. Effects of nicorandil on vascular and renal dysfunctions in adenine-induced nephropathy: Possible underlying mechanisms.
General physiology and biophysics.
2019 Nov; 38(6):545-556. doi:
10.4149/gpb_2019034. [PMID: 31588916] - Zhican Zeng, XiaoFeng Fu, Xue Zhang, Naikuan Fu. Comparison of double-dose vs. usual dose of nicorandil for the prevention of contrast-induced nephropathy after cardiac catheterization.
International urology and nephrology.
2019 Nov; 51(11):1999-2004. doi:
10.1007/s11255-019-02244-9. [PMID: 31385178] - Houyong Zhu, Xiaoqun Xu, Xiaojiang Fang, Jianwu Zheng, Qian Zhao, Tielong Chen, Jinyu Huang. Effects of the Antianginal Drugs Ranolazine, Nicorandil, and Ivabradine on Coronary Microvascular Function in Patients With Nonobstructive Coronary Artery Disease: A Meta-analysis of Randomized Controlled Trials.
Clinical therapeutics.
2019 10; 41(10):2137-2152.e12. doi:
10.1016/j.clinthera.2019.08.008. [PMID: 31548105] - Ali Khames, Marwa M Khalaf, Amany M Gad, Ola M Abd El-Raouf, Mohamed Ahmed Kandeil. Nicorandil combats doxorubicin-induced nephrotoxicity via amendment of TLR4/P38 MAPK/NFκ-B signaling pathway.
Chemico-biological interactions.
2019 Sep; 311(?):108777. doi:
10.1016/j.cbi.2019.108777. [PMID: 31376360] - Xuyang Wang, Jinyu Pan, Dian Liu, Mingjun Zhang, Xiaowei Li, Jingjing Tian, Ming Liu, Tao Jin, Fengshuang An. Nicorandil alleviates apoptosis in diabetic cardiomyopathy through PI3K/Akt pathway.
Journal of cellular and molecular medicine.
2019 08; 23(8):5349-5359. doi:
10.1111/jcmm.14413. [PMID: 31131539] - Jovana Bradic, Anica Petkovic, Nina Simonovic, Milan Radovanovic, Jovana Jeremic, Vladimir Zivkovic, Slobodanka Mitrovic, Sergey Bolevich, Vladimir Jakovljevic, Jasmina Sretenovic, Ivan Srejovic. Preconditioning with hyperbaric oxygen and calcium and potassium channel modulators in the rat heart.
Undersea & hyperbaric medicine : journal of the Undersea and Hyperbaric Medical Society, Inc.
2019 Jun; 46(4):483-494. doi:
. [PMID: 31509904] - Ghada Farouk Soliman, Laila Ahmed Rashed, Heba Morsi, Walaa Ibrahim, Hanan Abdallah, Nermeen Bastawy, Omnia Mohamed Abdel Maksoud. Interrelation of liver vascularity to non-alcoholic fatty liver through a comparative study of the vasodilator effect of carvedilol or nicorandil in rats.
Life sciences.
2019 Apr; 222(?):175-182. doi:
10.1016/j.lfs.2019.02.057. [PMID: 30826497] - Muhammed A Saad, Ayman E El-Sahhar, Hany H Arab, Muhammad Y Al-Shorbagy. Nicorandil abates arthritic perturbations induced by complete Freund's adjuvant in rats via conquering TLR4-MyD88-TRAF6 signaling pathway.
Life sciences.
2019 Feb; 218(?):284-291. doi:
10.1016/j.lfs.2019.01.002. [PMID: 30611783] - Houyong Zhu, Xiaoqun Xu, Xiaojiang Fang, Jianwu Zheng, Tielong Chen, Jinyu Huang. Effects of mitochondrial ATP-sensitive potassium channel activation (nicorandil) in patients with angina pectoris undergoing elective percutaneous coronary interventions: A meta-analysis of randomized controlled trials.
Medicine.
2019 Jan; 98(3):e14165. doi:
10.1097/md.0000000000014165. [PMID: 30653160] - Nina Simonovic, Vladimir Jakovljevic, Jovana Jeremic, Zarko Finderle, Ivan Srejovic, Tamara Nikolic Turnic, Isidora Milosavljevic, Vladimir Zivkovic. Comparative effects of calcium and potassium channel modulators on ischemia/reperfusion injury in the isolated rat heart.
Molecular and cellular biochemistry.
2019 Jan; 450(1-2):175-185. doi:
10.1007/s11010-018-3384-y. [PMID: 29922947] - Zeyuan Fan, Yang Li, Hanhua Ji, Xinwen Jian. Efficacy of Oral Nicorandil to Prevent Contrast-Induced Nephropathy in Patients with Chronic Renal Dysfunction Undergoing an Elective Coronary Procedure.
Kidney & blood pressure research.
2019; 44(6):1372-1382. doi:
10.1159/000503160. [PMID: 31639790] - M E Neganova, S G Klochkov, E F Shevtsova, T N Bogatyrenko, D V Mishchenko. Antioxidant Properties of a Pharmaceutical Substance Hypocard, a Potential Drug for Ischemic Disease.
Bulletin of experimental biology and medicine.
2018 Nov; 166(1):46-49. doi:
10.1007/s10517-018-4286-4. [PMID: 30417282] - Qiang Su, Xiangwei Lv, Yuhan Sun, Ziliang Ye, Binghui Kong, Zhenbai Qin. Role of TLR4/MyD88/NF-κB signaling pathway in coronary microembolization-induced myocardial injury prevented and treated with nicorandil.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.
2018 Oct; 106(?):776-784. doi:
10.1016/j.biopha.2018.07.014. [PMID: 29990871] - Meng Zhang, Huizhen Zhang, Chun Liu, Xuehui Li, Mingying Ling, Zhihao Wang, Yanqiu Xing. Myocardial Protective Effects of Nicorandil on Rats with Type 2 Diabetic Cardiomyopathy.
Medical science monitor basic research.
2018 Sep; 24(?):141-145. doi:
10.12659/msmbr.910974. [PMID: 30262799] - Yiliang Li, Hai Liu, Wei Peng, Zhi Song. Nicorandil improves clinical outcomes in patients with stable angina pectoris requiring PCI: a systematic review and meta-analysis of 14 randomized trials.
Expert review of clinical pharmacology.
2018 Sep; 11(9):855-865. doi:
10.1080/17512433.2018.1508342. [PMID: 30079778] - Biming Zhan, Xiao Huang, Long Jiang, Huihui Bao, XiaoShu Cheng. Effect of Nicorandil Administration on Preventing Contrast-Induced Nephropathy: A Meta-Analysis.
Angiology.
2018 Aug; 69(7):568-573. doi:
10.1177/0003319717732237. [PMID: 28950711] - Shuang Li, Lin Wang, Yucai Liu, Qiang Hu. Preventive effect of nicorandil on contrast-induced nephropathy: a meta-analysis of randomised controlled trials.
Internal medicine journal.
2018 08; 48(8):957-963. doi:
10.1111/imj.13962. [PMID: 29740934] - Xiaofen Ma, Xiang Li, Zhanfeng Jiao, Yiming Zhang. Nicorandil for the prevention of contrast-induced nephropathy: A meta-analysis of randomized controlled trials.
Cardiovascular therapeutics.
2018 Apr; 36(2):. doi:
10.1111/1755-5922.12316. [PMID: 29283501] - Ahmed Gaafar Ahmed Gaafar, Basim Anwar Shehata Messiha, Ahmed Mohamed Labib Abdelkafy. Nicorandil and theophylline can protect experimental rats against complete Freund's adjuvant-induced rheumatoid arthritis through modulation of JAK/STAT/RANKL signaling pathway.
European journal of pharmacology.
2018 Mar; 822(?):177-185. doi:
10.1016/j.ejphar.2018.01.009. [PMID: 29337196] - Shanjie Wang, Yanhong Fan, Xinyu Feng, Chuang Sun, Zhaofeng Shi, Tian Li, Jianjun Lv, Zhi Yang, Zhijing Zhao, Dongdong Sun. Nicorandil alleviates myocardial injury and post-infarction cardiac remodeling by inhibiting Mst1.
Biochemical and biophysical research communications.
2018 01; 495(1):292-299. doi:
10.1016/j.bbrc.2017.11.041. [PMID: 29127009] - Fengyun Zhang, Yongli Xuan, Jinjin Cui, Xinxin Liu, Zhiying Shao, Bo Yu. Nicorandil modulated macrophages activation and polarization via NF-κb signaling pathway.
Molecular immunology.
2017 08; 88(?):69-78. doi:
10.1016/j.molimm.2017.06.019. [PMID: 28609713] - Zhihua Pang, Wei Zhao, Zhuhua Yao. Cardioprotective Effects of Nicorandil on Coronary Heart Disease Patients Undergoing Elective Percutaneous Coronary Intervention.
Medical science monitor : international medical journal of experimental and clinical research.
2017 Jun; 23(?):2924-2930. doi:
10.12659/msm.902324. [PMID: 28617765] - Hayrettin Ozturk, Tulin Firat, Buket Kin Tekce, Fahri Yilmaz, Hulya Ozturk. Effects of nicorandil on renal function and histopathology in rats with partial unilateral ureteral obstruction.
The Kaohsiung journal of medical sciences.
2017 May; 33(5):236-245. doi:
10.1016/j.kjms.2017.03.003. [PMID: 28433070] - E Sánchez-Duarte, X Trujillo, C Cortés-Rojo, A Saavedra-Molina, G Camargo, L Hernández, M Huerta, R Montoya-Pérez. Nicorandil improves post-fatigue tension in slow skeletal muscle fibers by modulating glutathione redox state.
Journal of bioenergetics and biomembranes.
2017 Apr; 49(2):159-170. doi:
10.1007/s10863-016-9692-6. [PMID: 28054274] - Hsiu-Ting Chen, Yu-Te Wu, Wu-Chang Yang, Der-Cherng Tarng, Chih-Ching Lin. Nicorandil-Induced Hyperkalemia in a Hemodialysis Patient.
The American journal of the medical sciences.
2017 Apr; 353(4):411-412. doi:
10.1016/j.amjms.2016.10.004. [PMID: 28317633] - Sriram Ravindran, Jeyashri Murali, Sunil Kumar Amirthalingam, Senthilkumar Gopalakrishnan, Gino A Kurian. Vascular calcification abrogates the nicorandil mediated cardio-protection in ischemia reperfusion injury of rat heart.
Vascular pharmacology.
2017 02; 89(?):31-38. doi:
10.1016/j.vph.2016.12.004. [PMID: 28087358] - Sriram Ravindran, Krithika Swaminathan, Abhinaya Ramesh, Gino A Kurian. Nicorandil attenuates neuronal mitochondrial dysfunction and oxidative stress associated with murine model of vascular calcification.
Acta neurobiologiae experimentalis.
2017; 77(1):57-67. doi:
10.21307/ane-2017-036. [PMID: 28379216] - Leili Iranirad, Seyed Fakhreddin Hejazi, Mohammad Saleh Sadeghi, Shahram Arsang Jang. Efficacy of nicorandil treatment for prevention of contrast-induced nephropathy in high-risk patients undergoing cardiac catheterization: A prospective randomized controlled trial.
Cardiology journal.
2017; 24(5):502-507. doi:
10.5603/cj.a2017.0028. [PMID: 28281738] - Mari C Asensio-López, Fernando Soler, Domingo Pascual-Figal, Francisco Fernández-Belda, Antonio Lax. Doxorubicin-induced oxidative stress: The protective effect of nicorandil on HL-1 cardiomyocytes.
PloS one.
2017; 12(2):e0172803. doi:
10.1371/journal.pone.0172803. [PMID: 28245258] - Surbhi Gupta, Prabhat Singh, Bhupesh Sharma. Neuroprotective Effects of Nicorandil in Chronic Cerebral Hypoperfusion-Induced Vascular Dementia.
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association.
2016 Nov; 25(11):2717-2728. doi:
10.1016/j.jstrokecerebrovasdis.2016.07.023. [PMID: 27622862] - Yanming Fan, Qingmin Wei, Junna Cai, Yongtang Shi, Youliang Zhang, Limei Yao, Xiaogang Wang, Shupo Lin, Yilin Li, Jing Lv, Bin Zhou, Ruijuan Du. Preventive effect of oral nicorandil on contrast-induced nephropathy in patients with renal insufficiency undergoing elective cardiac catheterization.
Heart and vessels.
2016 Nov; 31(11):1776-1782. doi:
10.1007/s00380-016-0809-y. [PMID: 26874946] - Abdul Baquee Ahmed, Lila Kanta Nath. Design and development of controlled release floating matrix tablet of Nicorandil using hydrophilic cellulose and pH-independent acrylic polymer: in-vitro and in-vivo evaluations.
Expert opinion on drug delivery.
2016; 13(3):315-24. doi:
10.1517/17425247.2016.1118047. [PMID: 26559395] - Di Yu, Changfeng Fan, Weiyan Zhang, Zhongyuan Wen, Liang Hu, Lei Yang, Yu Feng, Ke-Jie Yin, Xuming Mo. Neuroprotective effect of nicorandil through inhibition of apoptosis by the PI3K/Akt1 pathway in a mouse model of deep hypothermic low flow.
Journal of the neurological sciences.
2015 Oct; 357(1-2):119-25. doi:
10.1016/j.jns.2015.07.010. [PMID: 26279331] - Lamiaa A Ahmed, Shohda A El-Maraghy, Sherine M Rizk. Role of the KATP channel in the protective effect of nicorandil on cyclophosphamide-induced lung and testicular toxicity in rats.
Scientific reports.
2015 Sep; 5(?):14043. doi:
10.1038/srep14043. [PMID: 26403947] - Takahide Nawa, Kazuhiko Nishigaki, Yujiro Kinomura, Toshiki Tanaka, Yoshihisa Yamada, Masanori Kawasaki, Shinya Minatoguchi. Continuous intravenous infusion of nicorandil for 4 hours before and 24 hours after percutaneous coronary intervention protects against contrast-induced nephropathy in patients with poor renal function.
International journal of cardiology.
2015 Sep; 195(?):228-34. doi:
10.1016/j.ijcard.2015.05.078. [PMID: 26048382] - Fengyun Zhang, Jinjin Cui, Bo Lv, Bo Yu. Nicorandil protects mesenchymal stem cells against hypoxia and serum deprivation-induced apoptosis.
International journal of molecular medicine.
2015 Aug; 36(2):415-23. doi:
10.3892/ijmm.2015.2229. [PMID: 26035532] - Yoshihito Tashiro, Kenji Yogo, Kenichi Serizawa, Koichi Endo. Nicorandil suppresses urinary protein excretion and activates eNOS in Dahl salt-sensitive hypertensive rats.
Clinical and experimental nephrology.
2015 Jun; 19(3):343-9. doi:
10.1007/s10157-014-0998-6. [PMID: 24952900] - Prabhat Singh, Surbhi Gupta, Bhupesh Sharma. Melatonin receptor and KATP channel modulation in experimental vascular dementia.
Physiology & behavior.
2015 Apr; 142(?):66-78. doi:
10.1016/j.physbeh.2015.02.009. [PMID: 25659733] - Masato Nishimura, Yu Okamoto, Toru Takatani, Nodoka Sato, Masaya Nishida, Tetsuya Hashimoto, Satoru Yamazaki, Hiroyuki Kobayashi, Toshihiko Ono. Improvement of myocardial fatty acid metabolism by oral nicorandil in hemodialysis patients without coronary artery disease.
Journal of nephrology.
2015 Apr; 28(2):227-34. doi:
10.1007/s40620-014-0125-5. [PMID: 25070153] - Zuoyuan Chen, Xiuhua Chen, Shan Li, Xuezhen Huo, Xiuxiu Fu, Xiaonan Dong. Nicorandil improves myocardial function by regulating plasma nitric oxide and endothelin-1 in coronary slow flow.
Coronary artery disease.
2015 Mar; 26(2):114-20. doi:
10.1097/mca.0000000000000179. [PMID: 25325437] - Ji-Min Sun, Chun-Miao Wang, Zeng Guo, Yu-Yu Hao, Yang-Jing Xie, Jian Gu, Ai-Ling Wang. Reduction of isoproterenol-induced cardiac hypertrophy and modulation of myocardial connexin43 by a KATP channel agonist.
Molecular medicine reports.
2015 Mar; 11(3):1845-50. doi:
10.3892/mmr.2014.2988. [PMID: 25411819] - Shimaa M Elshazly. Ameliorative effect of nicorandil on high fat diet induced non-alcoholic fatty liver disease in rats.
European journal of pharmacology.
2015 Feb; 748(?):123-32. doi:
10.1016/j.ejphar.2014.12.017. [PMID: 25542756] - Y A Rezvanova, A S Adamchik. [Evaluation of Anti-Ischemic and Cardioprotective Effects of Nicorandil in Patients With Stable Angina].
Kardiologiia.
2015; 55(8):21-5. doi:
10.18565/cardio.2015.8.21-25. [PMID: 26761967] - Takeshi Shiraishi, Yoshifuru Tamura, Kei Taniguchi, Masato Higaki, Shuko Ueda, Tomoko Shima, Michito Nagura, Takahiko Nakagawa, Richard J Johnson, Shunya Uchida. Combination of ACE inhibitor with nicorandil provides further protection in chronic kidney disease.
American journal of physiology. Renal physiology.
2014 Dec; 307(12):F1313-22. doi:
10.1152/ajprenal.00521.2014. [PMID: 25320353] - Lihua Liu, Yun Liu, Benling Qi, Qinqin Wu, Yuanyuan Li, Zhaohui Wang. Nicorandil attenuates endothelial VCAM-1 expression via thioredoxin production in diabetic rats induced by streptozotocin.
Molecular medicine reports.
2014 Jun; 9(6):2227-32. doi:
10.3892/mmr.2014.2066. [PMID: 24676284] - Isabela C César, Adriana M Godin, Débora P Araujo, Francinely C Oliveira, Raquel R Menezes, Julliana R A Santos, Mariana O Almeida, Marcela M G B Dutra, Daniel A Santos, Renes R Machado, Gerson A Pianetti, Márcio M Coelho, Angelo de Fátima. Synthesis, antinociceptive activity and pharmacokinetic profiles of nicorandil and its isomers.
Bioorganic & medicinal chemistry.
2014 May; 22(9):2783-90. doi:
10.1016/j.bmc.2014.03.011. [PMID: 24685703] - Ramzia El-Bagary, Hassan M E Azzazy, Ehab F ElKady, Faten Farouk. Simultaneous determination of sildenafil citrate and some nitric oxide releasing drugs in human plasma using UPLC MS/MS.
Clinical biochemistry.
2014 May; 47(7-8):654-6. doi:
10.1016/j.clinbiochem.2014.03.009. [PMID: 24685593] - Dorota Dymkowska, Beata Drabarek, Justyna Jakubczyk, Sylwia Wojciechowska, Krzysztof Zabłocki. Potassium channel openers prevent palmitate-induced insulin resistance in C2C12 myotubes.
Archives of biochemistry and biophysics.
2014 Jan; 541(?):47-52. doi:
10.1016/j.abb.2013.11.003. [PMID: 24262853] - Yasunori Suematsu, Yoshinobu Murasato, Shin-Ichiro Miura, Masataka Horiuchi, Tomohiko Yamamoto, Kohei Takata, Keijiro Saku. Safety and feasibility of high-dose administration of nicorandil before reperfusion therapy in acute myocardial infarction.
Cardiovascular intervention and therapeutics.
2013 Oct; 28(4):352-61. doi:
10.1007/s12928-013-0182-z. [PMID: 23625617] - Ihab T Abdel-Raheem, Ashraf Taye, Mekky M Abouzied. Cardioprotective effects of nicorandil, a mitochondrial potassium channel opener against doxorubicin-induced cardiotoxicity in rats.
Basic & clinical pharmacology & toxicology.
2013 Sep; 113(3):158-66. doi:
10.1111/bcpt.12078. [PMID: 23621757] - Young-Guk Ko, Byoung-Kwon Lee, Woong Chol Kang, Jae-Youn Moon, Yun Hyeong Cho, Seong Hun Choi, Myeong-Ki Hong, Yangsoo Jang, Jong-Youn Kim, Pil-Ki Min, Hyuck-Moon Kwon. Preventive effect of pretreatment with intravenous nicorandil on contrast-induced nephropathy in patients with renal dysfunction undergoing coronary angiography (PRINCIPLE Study).
Yonsei medical journal.
2013 Jul; 54(4):957-64. doi:
10.3349/ymj.2013.54.4.957. [PMID: 23709432] - Hidetoshi Hattori, Yuichiro Minami, Masayuki Mizuno, Dai Yumino, Hiromi Hoshi, Hiroyuki Arashi, Toshiaki Nuki, Yukiko Sashida, Michiaki Higashitani, Naoki Serizawa, Norihiro Yamada, Junichi Yamaguchi, Fumiaki Mori, Tsuyoshi Shiga, Nobuhisa Hagiwara. Differences in hemodynamic responses between intravenous carperitide and nicorandil in patients with acute heart failure syndromes.
Heart and vessels.
2013 May; 28(3):345-51. doi:
10.1007/s00380-012-0252-7. [PMID: 22526380] - Marcela M G B Dutra, Adriana M Godin, Isabela C César, Elias B Nascimento, Raquel R Menezes, Wallace C Ferreira, Darly G Soares, João Gabriel T Seniuk, Débora P Araújo, Leandro F S Bastos, Gerson A Pianetti, Ângelo de Fátima, Renes R Machado, Márcio M Coelho. Activity of nicorandil, a nicotinamide derivative with a nitrate group, in the experimental model of pain induced by formaldehyde in mice.
Pharmacology, biochemistry, and behavior.
2013 May; 106(?):85-90. doi:
10.1016/j.pbb.2013.03.004. [PMID: 23537730] - Ping Liang, Feng Lan, Andrew S Lee, Tingyu Gong, Veronica Sanchez-Freire, Yongming Wang, Sebastian Diecke, Karim Sallam, Joshua W Knowles, Paul J Wang, Patricia K Nguyen, Donald M Bers, Robert C Robbins, Joseph C Wu. Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity.
Circulation.
2013 Apr; 127(16):1677-91. doi:
10.1161/circulationaha.113.001883. [PMID: 23519760] - Norihisa Yasuda, Koji Goto, Ryo Shitomi, Yoshifumi Ohchi, Takakuni Abe, Shunsuke Yamamoto, Seigo Hidaka, Takayuki Noguchi. Should nicorandil infusion be adapted in dialysis-dependent patients undergoing continuous renal replacement therapy after cardiac surgery?.
Artificial organs.
2013 Mar; 37(3):319-22. doi:
10.1111/j.1525-1594.2012.01557.x. [PMID: 23146062] - Vanessa R S Foletto, Maria A Martins, Carlos R Tonussi. The involvement of potassium channels in the peripheral antiedematogenic effect of intrathecally injected morphine in rats.
Anesthesia and analgesia.
2013 Jan; 116(1):232-8. doi:
10.1213/ane.0b013e31826f5cc5. [PMID: 23223096] - Yu-Jing Zhang, Ai-Qi Zhang, Xia-Xia Zhao, Zhi-Liang Tian, Li Yao. Nicorandil protects against ischaemia-reperfusion injury in newborn rat kidney.
Pharmacology.
2013; 92(5-6):245-56. doi:
10.1159/000355060. [PMID: 24247737] - Kenichi Serizawa, Kenji Yogo, Yoshihito Tashiro, Nobuo Koike, Ken Aizawa, Michinori Hirata, Nobuhiko Ishizuka. Nicorandil ameliorated hypertensive renal injury without lowering blood pressure in spontaneously hypertensive rats.
Pharmacology.
2013; 91(1-2):92-103. doi:
10.1159/000345811. [PMID: 23306764] - Fumiya Ohmasa, Motoaki Saito, Harunori Oiwa, Panagiota Tsounapi, Kohei Shomori, Kazuyuki Kitatani, Fotios Dimitriadis, Yukako Kinoshita, Keisuke Satoh. Pharmacological preconditioning of ATP-sensitive potassium channel openers on acute urinary retention-induced bladder dysfunction in the rat.
BJU international.
2012 Sep; 110(6 Pt B):E245-52. doi:
10.1111/j.1464-410x.2012.10965.x. [PMID: 22369430] - Yoshifuru Tamura, Katsuyuki Tanabe, Wataru Kitagawa, Shunya Uchida, George F Schreiner, Richard J Johnson, Takahiko Nakagawa. Nicorandil, a K(atp) channel opener, alleviates chronic renal injury by targeting podocytes and macrophages.
American journal of physiology. Renal physiology.
2012 Aug; 303(3):F339-49. doi:
10.1152/ajprenal.00158.2012. [PMID: 22622455] - Yan Xingyu, Tan Guoliang, Cai Youmei, Wang Honggen, Guo Yihong, Chen Junyi. The effect of nitric oxide on the pressure of the acutely obstructed ureter.
Urological research.
2012 Apr; 40(2):163-9. doi:
10.1007/s00240-011-0395-5. [PMID: 21695424] - Yun-Fei Xia, Zheng-Ping Wang, Ya-Chun Zhou, Tao Yan, Shi-Tong Li. Cerebral protective effect of nicorandil premedication on patients undergoing liver transplantation.
Hepatobiliary & pancreatic diseases international : HBPD INT.
2012 Apr; 11(2):132-6. doi:
10.1016/s1499-3872(12)60137-4. [PMID: 22484579] - U Deniz Dincer. Cardiac ryanodine receptor in metabolic syndrome: is JTV519 (K201) future therapy?.
Diabetes, metabolic syndrome and obesity : targets and therapy.
2012; 5(?):89-99. doi:
10.2147/dmso.s30005. [PMID: 22563249] - Takayuki Kitamura, Kanako Sato, Gaku Kawamura, Yoshitsugu Yamada. The involvement of adenosine triphosphate-sensitive potassium channels in the different effects of sevoflurane and propofol on glucose metabolism in fed rats.
Anesthesia and analgesia.
2012 Jan; 114(1):110-6. doi:
10.1213/ane.0b013e3182373552. [PMID: 22127813] - Tomonori Kimura, Harumi Kitamura, Kazunori Inoue, Noritaka Kawada, Isao Matsui, Yasuyuki Nagasawa, Yoshitsugu Obi, Maki Shinzawa, Yasuhiko Sakata, Takayuki Hamono, Hiromi Rakugi, Yoshitaka Isaka. Effects of nicorandil on the reduction of BNP levels in patients with chronic kidney disease.
Clinical and experimental nephrology.
2011 Dec; 15(6):854-60. doi:
10.1007/s10157-011-0522-1. [PMID: 21858735] - Isabela Costa César, Leandro Francisco Silva Bastos, Adriana Martins Godin, Márcio de Matos Coelho, Débora Pereira Araujo, Ângelo de Fátima, Patrícia Alves Maia Guidine, Gerson Antônio Pianetti. Simultaneous quantitation of nicorandil and its denitrated metabolite in plasma by LC-MS/MS: application for a pharmacokinetic study.
Journal of mass spectrometry : JMS.
2011 Nov; 46(11):1125-30. doi:
10.1002/jms.1998. [PMID: 22124983] - Lamiaa A Ahmed, Hesham A Salem, Amina S Attia, Azza M Agha. Pharmacological preconditioning with nicorandil and pioglitazone attenuates myocardial ischemia/reperfusion injury in rats.
European journal of pharmacology.
2011 Aug; 663(1-3):51-8. doi:
10.1016/j.ejphar.2011.04.038. [PMID: 21549700] - Shogo Shimizu, Motoaki Saito, Yukako Kinoshita, Fumiya Ohmasa, Fotios Dimitriadis, Kohei Shomori, Atsushi Hayashi, Keisuke Satoh. Nicorandil ameliorates ischaemia-reperfusion injury in the rat kidney.
British journal of pharmacology.
2011 May; 163(2):272-82. doi:
10.1111/j.1476-5381.2011.01231.x. [PMID: 21250976] - Hodaka Yamazaki, Kiyohiro Oshima, Hiroaki Sato, Katumi Kobayashi, Yujin Suto, Keitaro Hirai, Hiroki Odawara, Koshi Matsumoto, Izumi Takeyoshi. The effect of nicorandil on ischemia-reperfusion injury in a porcine total hepatic vascular exclusion model.
The Journal of surgical research.
2011 May; 167(1):49-55. doi:
10.1016/j.jss.2009.09.049. [PMID: 20080259] - K J Wadher, R B Kakde, M J Umekar. Formulation and evaluation of a sustained-release tablets of metformin hydrochloride using hydrophilic synthetic and hydrophobic natural polymers.
Indian journal of pharmaceutical sciences.
2011 Mar; 73(2):208-15. doi:
10.4103/0250-474x.91579. [PMID: 22303065] - Chongming Wu, Yan Li, Yan Chen, Xinyuan Lao, Linghui Sheng, Rongji Dai, Weiwei Meng, Yulin Deng. Hypoglycemic effect of Belamcanda chinensis leaf extract in normal and STZ-induced diabetic rats and its potential active faction.
Phytomedicine : international journal of phytotherapy and phytopharmacology.
2011 Feb; 18(4):292-7. doi:
10.1016/j.phymed.2010.07.005. [PMID: 20739161] - Yasuhiro Izumiya, Sunao Kojima, Shinobu Kojima, Satoshi Araki, Hiroki Usuku, Junichi Matsubara, Kenji Sakamoto, Kenichi Tsujita, Yasuhiro Nagayoshi, Koichi Kaikita, Seigo Sugiyama, Hisao Ogawa. Long-term use of oral nicorandil stabilizes coronary plaque in patients with stable angina pectoris.
Atherosclerosis.
2011 Feb; 214(2):415-21. doi:
10.1016/j.atherosclerosis.2010.11.032. [PMID: 21168844]
