LSM-1839 (BioDeep_00000003154)
Secondary id: BioDeep_00000405954
代谢物信息卡片
Naltrindole
化学式: C26H26N2O3 (414.19433260000005)
中文名称:
谱图信息:
最多检出来源 Mentha canadensis(plant) 90.91%
分子结构信息
SMILES: C1CC1CN2CCC34C5C6=C(CC3(C2CC7=C4C(=C(C=C7)O)O5)O)C8=CC=CC=C8N6
InChI: InChI=1S/C26H26N2O3/c29-19-8-7-15-11-20-26(30)12-17-16-3-1-2-4-18(16)27-22(17)24-25(26,21(15)23(19)31-24)9-10-28(20)13-14-5-6-14/h1-4,7-8,14,20,24,27,29-30H,5-6,9-13H2
描述信息
D002492 - Central Nervous System Depressants > D009294 - Narcotics > D053610 - Opiate Alkaloids
D018373 - Peripheral Nervous System Agents > D018689 - Sensory System Agents
D002491 - Central Nervous System Agents > D009292 - Narcotic Antagonists
同义名列表
4 个代谢物同义名
数据库引用编号
14 个数据库交叉引用编号
- ChEBI: CHEBI:91903
- ChEBI: CHEBI:81528
- KEGG: C18128
- PubChem: 5497186
- Metlin: METLIN72052
- ChEMBL: CHEMBL1237164
- ChEMBL: CHEMBL567175
- CAS: 111555-53-4
- PMhub: MS000008300
- MetaboLights: MTBLC91903
- PubChem: 96024345
- PDB-CCD: EJ4
- NIKKAJI: J304.821G
- KNApSAcK: 81528
分类词条
相关代谢途径
Reactome(0)
BioCyc(0)
PlantCyc(0)
代谢反应
0 个相关的代谢反应过程信息。
Reactome(0)
BioCyc(0)
WikiPathways(0)
Plant Reactome(0)
INOH(0)
PlantCyc(0)
COVID-19 Disease Map(0)
PathBank(0)
PharmGKB(0)
0 个相关的物种来源信息
在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：
- PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
- NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
- Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
- Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。
点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。
文献列表
- Fengbao Luo, Renfang Xu, Guanglai Song, Dong Xue, Xiaozhou He, Ying Xia. Alleviation of TGF-β1 induced tubular epithelial-mesenchymal transition via the δ-opioid receptor.
The FEBS journal.
2021 02; 288(4):1243-1258. doi:
10.1111/febs.15459. [PMID: 32563195] - Scott E Hemby, Scot McIntosh, Francisco Leon, Stephen J Cutler, Christopher R McCurdy. Abuse liability and therapeutic potential of the Mitragyna speciosa (kratom) alkaloids mitragynine and 7-hydroxymitragynine.
Addiction biology.
2019 09; 24(5):874-885. doi:
10.1111/adb.12639. [PMID: 29949228] - Takaaki Komatsu, Soh Katsuyama, Fumihide Takano, Takemasa Okamura, Chikai Sakurada, Minoru Tsuzuki, Kakuyou Ogawa, Atsuhito Kubota, Osamu Morinaga, Kenji Tabata, Tsukasa Sakurada. Possible involvement of the μ opioid receptor in the antinociception induced by sinomenine on formalin-induced nociceptive behavior in mice.
Neuroscience letters.
2019 04; 699(?):103-108. doi:
10.1016/j.neulet.2019.01.035. [PMID: 30690119] - Mario García-Domínguez, Ana Lastra, Alicia R Folgueras, Rafael Cernuda-Cernuda, María Teresa Fernández-García, Agustín Hidalgo, Luis Menéndez, Ana Baamonde. The Chemokine CCL4 (MIP-1β) Evokes Antinociceptive Effects in Mice: a Role for CD4+ Lymphocytes and Met-Enkephalin.
Molecular neurobiology.
2019 Mar; 56(3):1578-1595. doi:
10.1007/s12035-018-1176-8. [PMID: 29907903] - Toshio Yawata, Youichirou Higashi, Takahiro Shimizu, Shogo Shimizu, Kumiko Nakamura, Keisuke Taniuchi, Tetsuya Ueba, Motoaki Saito. Brain opioid and nociceptin receptors are involved in regulation of bombesin-induced activation of central sympatho-adrenomedullary outflow in the rat.
Molecular and cellular biochemistry.
2016 Jan; 411(1-2):201-11. doi:
10.1007/s11010-015-2582-0. [PMID: 26427671] - Prabhakar R Polepally, Krzysztof Huben, Eyal Vardy, Vincent Setola, Philip D Mosier, Bryan L Roth, Jordan K Zjawiony. Michael acceptor approach to the design of new salvinorin A-based high affinity ligands for the kappa-opioid receptor.
European journal of medicinal chemistry.
2014 Oct; 85(?):818-29. doi:
10.1016/j.ejmech.2014.07.077. [PMID: 25193297] - E Dobek, K Górski, K Romanowicz, T Misztal. Different types of opioid receptors involved in the suppression of LH secretion in lactating sheep.
Animal reproduction science.
2013 Sep; 141(1-2):62-7. doi:
10.1016/j.anireprosci.2013.07.006. [PMID: 23953813] - Prabhakar R Polepally, Kate White, Eyal Vardy, Bryan L Roth, Daneel Ferreira, Jordan K Zjawiony. Kappa-opioid receptor-selective dicarboxylic ester-derived salvinorin A ligands.
Bioorganic & medicinal chemistry letters.
2013 May; 23(10):2860-2. doi:
10.1016/j.bmcl.2013.03.111. [PMID: 23587424] - Alana de Freitas Pires, Ana Maria Sampaio Assreuy, Érika Augusta Batista Lopes, Natália Rocha Celedônio, Carlos Eduardo Alves Soares, Natália Velloso Fontenelle Camelo Rodrigues, Paloma Leão Sousa, Raquel Guimarães Benevides, Celso Shiniti Nagano, Benildo Sousa Cavada, José Henrique Leal-Cardoso, Andrelina Noronha Coelho-de-Souza, Cláudia Ferreira Santos. Opioid-like antinociceptive effects of oral administration of a lectin purified from the seeds of Canavalia brasiliensis.
Fundamental & clinical pharmacology.
2013 Apr; 27(2):201-9. doi:
10.1111/j.1472-8206.2011.00987.x. [PMID: 21895762] - Gary S Wand, Elise M Weerts, Hiroto Kuwabara, Dean F Wong, Xiaoqiang Xu, Mary E McCaul. The relationship between naloxone-induced cortisol and delta opioid receptor availability in mesolimbic structures is disrupted in alcohol-dependent subjects.
Addiction biology.
2013 Jan; 18(1):181-92. doi:
10.1111/j.1369-1600.2011.00430.x. [PMID: 22264217] - Bo Tang, Yi Zhang, Rui Liang, Peng Yuan, Jian Du, Hongxin Wang, Liming Wang. Activation of the δ-opioid receptor inhibits serum deprivation-induced apoptosis of human liver cells via the activation of PKC and the mitochondrial pathway.
International journal of molecular medicine.
2011 Dec; 28(6):1077-85. doi:
10.3892/ijmm.2011.784. [PMID: 21874227] - Ellen E Codd, Jianya Ma, Sui-Po Zhang, Dennis J Stone, Raymond W Colburn, Michael R Brandt, Kristen M Chevalier, Yongxin Zhu, Sean Peng, Chaozhong Cai, Paul D Acton, Christopher M Flores. Ex vivo delta opioid receptor autoradiography: CNS receptor occupancy of two novel compounds over their antihyperalgesic dose range.
Pharmacology, biochemistry, and behavior.
2010 Aug; 96(2):130-5. doi:
10.1016/j.pbb.2010.04.020. [PMID: 20438745] - Pai-Huei Peng, Ho-Shiang Huang, Yih-Jing Lee, Yih-Sharng Chen, Ming-Chieh Ma. Novel role for the delta-opioid receptor in hypoxic preconditioning in rat retinas.
Journal of neurochemistry.
2009 Feb; 108(3):741-54. doi:
10.1111/j.1471-4159.2008.05807.x. [PMID: 19054276] - Seung R Han, Min K Lee, Koang H Lim, Gwi Y Yang, Hye J Jeon, Jin S Ju, Young W Yoon, Sung K Kim, Dong K Ahn. Intramuscular administration of morphine reduces mustard-oil-induced craniofacial-muscle pain behavior in lightly anesthetized rats.
European journal of pain (London, England).
2008 Apr; 12(3):361-70. doi:
10.1016/j.ejpain.2007.07.002. [PMID: 17768078] - Penelope J Hallett, J M Brotchie. Striatal delta opioid receptor binding in experimental models of Parkinson's disease and dyskinesia.
Movement disorders : official journal of the Movement Disorder Society.
2007 Jan; 22(1):28-40. doi:
10.1002/mds.21163. [PMID: 17089424] - Trentini F John, Larry G French, Joseph S Erlichman. The antinociceptive effect of salvinorin A in mice.
European journal of pharmacology.
2006 Sep; 545(2-3):129-33. doi:
10.1016/j.ejphar.2006.06.077. [PMID: 16905132] - Gavin Bart, James H Schluger, Lisa Borg, Ann Ho, Jean M Bidlack, Mary Jeanne Kreek. Nalmefene induced elevation in serum prolactin in normal human volunteers: partial kappa opioid agonist activity?.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.
2005 Dec; 30(12):2254-62. doi:
10.1038/sj.npp.1300811. [PMID: 15988468] - William E Fantegrossi, Kelly M Kugle, Leander J Valdes, Masato Koreeda, James H Woods. Kappa-opioid receptor-mediated effects of the plant-derived hallucinogen, salvinorin A, on inverted screen performance in the mouse.
Behavioural pharmacology.
2005 Dec; 16(8):627-33. doi:
10.1097/00008877-200512000-00005. [PMID: 16286814] - Akiyoshi Saitoh, Yuji Yoshikawa, Kenji Onodera, Junzo Kamei. Role of delta-opioid receptor subtypes in anxiety-related behaviors in the elevated plus-maze in rats.
Psychopharmacology.
2005 Nov; 182(3):327-34. doi:
10.1007/s00213-005-0112-6. [PMID: 16075288] - Miaw-Chyi Luo, Dong-Qin Zhang, Shou-Wu Ma, Yuan-Yuan Huang, Sam J Shuster, Frank Porreca, Josephine Lai. An efficient intrathecal delivery of small interfering RNA to the spinal cord and peripheral neurons.
Molecular pain.
2005 Sep; 1(?):29. doi:
10.1186/1744-8069-1-29. [PMID: 16191203] - Louis R Lucas, Claudia A Grillo, Bruce S McEwen. Involvement of mesolimbic structures in short-term sodium depletion: in situ hybridization and ligand-binding analyses.
Neuroendocrinology.
2003 Jun; 77(6):406-15. doi:
10.1159/000071312. [PMID: 12845226] - K L Williams, M C Holden Ko, K C Rice, J H Woods. Effect of opioid receptor antagonists on hypothalamic-pituitary-adrenal activity in rhesus monkeys.
Psychoneuroendocrinology.
2003 May; 28(4):513-28. doi:
10.1016/s0306-4530(02)00037-9. [PMID: 12689609] - Z B Andrews, D R Grattan. Opioid receptor subtypes involved in the regulation of prolactin secretion during pregnancy and lactation.
Journal of neuroendocrinology.
2003 Mar; 15(3):227-36. doi:
10.1046/j.1365-2826.2003.00975.x. [PMID: 12588510] - Shuzhang Yang, Yukio Kawamura, Masaaki Yoshikawa. Effect of rubiscolin, a delta opioid peptide derived from Rubisco, on memory consolidation.
Peptides.
2003 Feb; 24(2):325-8. doi:
10.1016/s0196-9781(03)00044-5. [PMID: 12668220] - F J Miao, N L Benowitz, J D Levine. Endogenous opioids suppress activation of nociceptors by sub-nanomolar nicotine.
British journal of pharmacology.
2001 May; 133(1):23-8. doi:
10.1038/sj.bjp.0704031. [PMID: 11325790] - Z Salamon, S Cowell, E Varga, H I Yamamura, V J Hruby, G Tollin. Plasmon resonance studies of agonist/antagonist binding to the human delta-opioid receptor: new structural insights into receptor-ligand interactions.
Biophysical journal.
2000 Nov; 79(5):2463-74. doi:
10.1016/s0006-3495(00)76489-7. [PMID: 11053123] - G Bonner, F Meng, H Akil. Selectivity of mu-opioid receptor determined by interfacial residues near third extracellular loop.
European journal of pharmacology.
2000 Sep; 403(1-2):37-44. doi:
10.1016/s0014-2999(00)00578-1. [PMID: 10969141] - A M Abdel-Fattah, K Matsumoto, H Watanabe. Antinociceptive effects of Nigella sativa oil and its major component, thymoquinone, in mice.
European journal of pharmacology.
2000 Jul; 400(1):89-97. doi:
10.1016/s0014-2999(00)00340-x. [PMID: 10913589] - T Sasaki, K Arakawa, K Shimada, N Saito. The effects of highly selective opioid receptor antagonists on the release of arginine vasotocin induced by hyperosmotic stimulation and angiotensin II injection.
General and comparative endocrinology.
2000 Jun; 118(3):365-72. doi:
10.1006/gcen.2000.7470. [PMID: 10843787] - A Coop, J Pinto, L Wang, K McCullough, R B Rothman, C Dersch, A E Jacobson, K C Rice. Delta opioid binding selectivity of 3-ether analogs of naltrindole.
Bioorganic & medicinal chemistry letters.
1999 Dec; 9(24):3435-8. doi:
10.1016/s0960-894x(99)00622-8. [PMID: 10617086] - I Alberti, B Fernández, L F Alguacil, A Aguilar, M Caamaño, E M Romero, M P Viveros. Preweanling naltrindole administration differentially affects clonidine induced antinociception and plasma adrenaline levels in male and female neonatal rats.
British journal of pharmacology.
1999 Nov; 128(5):953-60. doi:
10.1038/sj.bjp.0702852. [PMID: 10556931] - J S Smith, J K Zubieta, J C Price, J E Flesher, I Madar, J R Lever, C M Kinter, R F Dannals, J J Frost. Quantification of delta-opioid receptors in human brain with N1'-([11C]methyl) naltrindole and positron emission tomography.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
1999 Sep; 19(9):956-66. doi:
10.1097/00004647-199909000-00003. [PMID: 10478647] - A Coop, R B Rothman, C Dersch, J Partilla, F Porreca, P Davis, A E Jacobson, K C Rice. delta Opioid affinity and selectivity of 4-hydroxy-3-methoxyindolomorphinan analogues related to naltrindole.
Journal of medicinal chemistry.
1999 May; 42(9):1673-9. doi:
10.1021/jm9807003. [PMID: 10229636] - Iu B Lishmanov, L A Maĭmeskulova, E V Uskina, L N Maslov. [Opiatergic mechanisms of cardioprotective and anti-arrhythmic effects of adaptation].
Biulleten' eksperimental'noi biologii i meditsiny.
1999 Feb; 127(2):167-70. doi:
". [PMID: 10095946] - M D Aceto, L S Harris, M E Abood, K C Rice. Stereoselective mu- and delta-opioid receptor-related antinociception and binding with (+)-thebaine.
European journal of pharmacology.
1999 Jan; 365(2-3):143-7. doi:
10.1016/s0014-2999(98)00862-0. [PMID: 9988096] - S F Sezen, V A Kenigs, D R Kapusta. Renal excretory responses produced by the delta opioid agonist, BW373U86, in conscious rats.
The Journal of pharmacology and experimental therapeutics.
1998 Oct; 287(1):238-45. doi:
NULL. [PMID: 9765343] - K M Linner, B J Stickney, H E Quist, B M Sharp, P S Portoghese. The delta1-opioid receptor antagonist, 7-(benzospiroindanyl)naltrexone [correction of 7-benzylspiroindanylnaltrexone], prolongs renal allograft survival in a rat model.
European journal of pharmacology.
1998 Jul; 354(1):R3-5. doi:
10.1016/s0014-2999(98)00477-4. [PMID: 9726640] - T Kshirsagar, A H Nakano, P Y Law, R Elde, P S Portoghese. NTI4F: a non-peptide fluorescent probe selective for functional delta opioid receptors.
Neuroscience letters.
1998 Jun; 249(2-3):83-6. doi:
10.1016/s0304-3940(98)00379-6. [PMID: 9682822] - H Kubota, R B Rothman, C Dersch, K McCullough, J Pinto, K C Rice. Synthesis and biological activity of 3-substituted 3-desoxynaltrindole derivatives.
Bioorganic & medicinal chemistry letters.
1998 Apr; 8(7):799-804. doi:
10.1016/s0960-894x(98)00105-x. [PMID: 9871544] - S Thongpradichote, K Matsumoto, M Tohda, H Takayama, N Aimi, S Sakai, H Watanabe. Identification of opioid receptor subtypes in antinociceptive actions of supraspinally-administered mitragynine in mice.
Life sciences.
1998; 62(16):1371-8. doi:
10.1016/s0024-3205(98)00075-7. [PMID: 9585164] - M Bertolucci, C Perego, M G De Simoni. Interleukin-6 is differently modulated by central opioid receptor subtypes.
The American journal of physiology.
1997 Sep; 273(3 Pt 2):R956-9. doi:
10.1152/ajpregu.1997.273.3.r956. [PMID: 9321873] - S Józefowski, B Płytycz. Characterization of opiate binding sites on the goldfish (Carassius auratus L.) pronephric leukocytes.
Polish journal of pharmacology.
1997 Aug; 49(4):229-37. doi:
NULL. [PMID: 9437766] - Iu B Lishmanov, L N Maslov, A V Krylamov, E V Uskina. [The role of endogenous opioid peptides in the mechanisms of the antiarrhythmic effect of adaptation].
Fiziologicheskii zhurnal imeni I.M. Sechenova.
1996 May; 82(5-6):48-52. doi:
NULL. [PMID: 9053071] - A Kawabata, K Iwatsubo, S Takaya, H Takagi. Central antinociceptive effect of L-ornithine, a metabolite of L-arginine, in rats and mice.
European journal of pharmacology.
1996 Jan; 296(1):23-31. doi:
10.1016/0014-2999(95)00683-4. [PMID: 8720473] - Y Sasaki, T Chiba. Novel deltorphin heptapeptide analogs with potent delta agonist, delta antagonist, or mixed mu antagonist/delta agonist properties.
Journal of medicinal chemistry.
1995 Sep; 38(20):3995-9. doi:
10.1021/jm00020a013. [PMID: 7562933] - N A Shahabi, B M Sharp. Delta opioid agonists inhibit proliferation of highlypurified murine CD4+ and CD8+ T-cells.
Advances in experimental medicine and biology.
1995; 373(?):29-36. doi:
10.1007/978-1-4615-1951-5_5. [PMID: 7668157] - K Arakawa, T Akami, M Okamoto, K Akioka, I Nakai, T Oka, H Nagase. Immunosuppression by delta opioid receptor antagonist.
Transplantation proceedings.
1993 Feb; 25(1 Pt 1):738-40. doi:
NULL. [PMID: 8382386] - K Arakawa, T Akami, M Okamoto, T Oka, H Nagase, S Matsumoto. The immunosuppressive effect of delta-opioid receptor antagonist on rat renal allograft survival.
Transplantation.
1992 Apr; 53(4):951-3. doi:
NULL. [PMID: 1314442] - I Kitchen, S R Pinker. Antagonism of swim-stress-induced antinociception by the delta-opioid receptor antagonist naltrindole in adult and young rats.
British journal of pharmacology.
1990 Aug; 100(4):685-8. doi:
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