Propantheline (BioDeep_00000002986)

 

Secondary id: BioDeep_00001868092

human metabolite blood metabolite Chemicals and Drugs


代谢物信息卡片


methylbis(propan-2-yl)[2-(9H-xanthene-9-carbonyloxy)ethyl]azanium

化学式: C23H30NO3+ (368.2226)
中文名称:
谱图信息: 最多检出来源 Mentha canadensis(plant) 74.07%

分子结构信息

SMILES: CC(C)[N+](C)(CCOC(=O)C1C2=CC=CC=C2OC2=CC=CC=C12)C(C)C
InChI: InChI=1S/C23H30NO3/c1-16(2)24(5,17(3)4)14-15-26-23(25)22-18-10-6-8-12-20(18)27-21-13-9-7-11-19(21)22/h6-13,16-17,22H,14-15H2,1-5H3/q+1

描述信息

Propantheline is only found in individuals that have used or taken this drug. It is a muscarinic antagonist used as an antispasmodic, in rhinitis, in urinary incontinence, and in the treatment of ulcers. At high doses it has nicotinic effects resulting in neuromuscular blocking. [PubChem]The action of propantheline is achieved via a dual mechanism: (1) a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites and (2) a direct effect upon smooth muscle (musculotropic).
A - Alimentary tract and metabolism > A03 - Drugs for functional gastrointestinal disorders > A03A - Drugs for functional gastrointestinal disorders > A03AB - Synthetic anticholinergics, quaternary ammonium compounds
C78272 - Agent Affecting Nervous System > C66880 - Anticholinergic Agent > C29704 - Antimuscarinic Agent
D018377 - Neurotransmitter Agents > D018678 - Cholinergic Agents > D018680 - Cholinergic Antagonists
D005765 - Gastrointestinal Agents > D000897 - Anti-Ulcer Agents

同义名列表

10 个代谢物同义名

methylbis(propan-2-yl)[2-(9H-xanthene-9-carbonyloxy)ethyl]azanium; Bromide, propantheline; propantheline bromide; Propanthelinium; Propanthelinum; propantheline; Pro banthine; Pro-banthine; Probanthine; Propantheline



数据库引用编号

14 个数据库交叉引用编号

分类词条

相关代谢途径

Reactome(0)

BioCyc(0)

PlantCyc(0)

代谢反应

0 个相关的代谢反应过程信息。

Reactome(0)

BioCyc(0)

WikiPathways(0)

Plant Reactome(0)

INOH(0)

PlantCyc(0)

COVID-19 Disease Map(0)

PathBank(0)

PharmGKB(0)

1 个相关的物种来源信息

在这里通过桑基图来展示出与当前的这个代谢物在我们的BioDeep知识库中具有相关联信息的其他代谢物。在这里进行关联的信息来源主要有：

  • PubMed: 来源于PubMed文献库中的文献信息，我们通过自然语言数据挖掘得到的在同一篇文献中被同时提及的相关代谢物列表，这个列表按照代谢物同时出现的文献数量降序排序，取前10个代谢物作为相关研究中关联性很高的代谢物集合展示在桑基图中。
  • NCBI Taxonomy: 通过文献数据挖掘，得到的代谢物物种来源信息关联。这个关联信息同样按照出现的次数降序排序，取前10个代谢物作为高关联度的代谢物集合展示在桑吉图上。
  • Chemical Taxonomy: 在物质分类上处于同一个分类集合中的其他代谢物
  • Chemical Reaction: 在化学反应过程中，存在为当前代谢物相关联的生化反应过程中的反应底物或者反应产物的关联代谢物信息。

点击图上的相关代谢物的名称，可以跳转到相关代谢物的信息页面。

亚细胞结构定位 关联基因列表
Cytoplasm 6 ABCB1, AXIN2, CEL, CFTR, CYP2D6, PPY
Endosome membrane 1 CFTR
Endoplasmic reticulum membrane 2 CFTR, CYP2D6
Nucleus 2 AXIN2, CFTR
cytosol 4 AXIN2, CFTR, LIPE, SST
centrosome 1 AXIN2
Cell membrane 4 ABCB1, CFTR, LIPE, P2RY4
Early endosome membrane 1 CFTR
Multi-pass membrane protein 5 ABCB1, CFTR, KCNA3, NNT, P2RY4
Synapse 1 CRH
cell surface 2 ABCB1, CFTR
glutamatergic synapse 2 KCNA3, P2RY4
Golgi membrane 1 INS
lysosomal membrane 1 CFTR
mitochondrial inner membrane 1 NNT
neuronal cell body 1 SST
presynaptic membrane 1 KCNA3
Cytoplasm, cytosol 1 LIPE
plasma membrane 7 ABCB1, AXIN2, CFTR, CSF2, GCG, KCNA3, P2RY4
terminal bouton 1 GHRH
Membrane 6 ABCB1, CFTR, CYP2D6, KCNA3, LIPE, NNT
apical plasma membrane 3 ABCB1, CFTR, P2RY4
axon 1 KCNA3
basolateral plasma membrane 1 P2RY4
caveola 1 LIPE
extracellular exosome 2 ABCB1, CEL
endoplasmic reticulum 1 CYP2D6
extracellular space 10 CEL, CRH, CSF2, GAST, GCG, GHRH, INS, PPY, SCT, SST
perinuclear region of cytoplasm 1 KCNA3
mitochondrion 2 CYP2D6, NNT
protein-containing complex 1 CFTR
intracellular membrane-bounded organelle 2 CSF2, CYP2D6
Microsome membrane 1 CYP2D6
Secreted 8 CEL, CRH, CSF2, GAST, GCG, INS, PPY, SST
extracellular region 10 CEL, CRH, CSF2, GAST, GCG, GHRH, INS, PPY, SCT, SST
Single-pass membrane protein 1 CYP2D6
varicosity 1 CRH
neuronal dense core vesicle lumen 1 CRH
perikaryon 2 CRH, GHRH
beta-catenin destruction complex 1 AXIN2
Early endosome 1 CFTR
recycling endosome 1 CFTR
postsynaptic membrane 1 KCNA3
presynaptic active zone membrane 1 P2RY4
Apical cell membrane 2 ABCB1, CFTR
Mitochondrion inner membrane 1 NNT
Matrix side 1 NNT
Membrane raft 1 KCNA3
GABA-ergic synapse 1 SST
[Isoform 2]: Cell membrane 1 KCNA3
Recycling endosome membrane 1 CFTR
endosome lumen 1 INS
Lipid droplet 1 LIPE
Membrane, caveola 1 LIPE
chloride channel complex 1 CFTR
Golgi-associated vesicle membrane 1 CFTR
respiratory chain complex 1 NNT
voltage-gated potassium channel complex 1 KCNA3
secretory granule lumen 2 GCG, INS
Golgi lumen 1 INS
endoplasmic reticulum lumen 2 GCG, INS
transport vesicle 1 INS
Endoplasmic reticulum-Golgi intermediate compartment membrane 1 INS
neuronal dense core vesicle 1 SST
calyx of Held 1 KCNA3
clathrin-coated endocytic vesicle membrane 1 CFTR
external side of apical plasma membrane 1 ABCB1
[Isoform 1]: Cell membrane 1 KCNA3
granulocyte macrophage colony-stimulating factor receptor complex 1 CSF2
[Glucagon-like peptide 1]: Secreted 1 GCG
[Isoform 3]: Cytoplasm, perinuclear region 1 KCNA3


文献列表

  • Mark J Henderson, Kathleen A Trychta, Shyh-Ming Yang, Susanne Bäck, Adam Yasgar, Emily S Wires, Carina Danchik, Xiaokang Yan, Hideaki Yano, Lei Shi, Kuo-Jen Wu, Amy Q Wang, Dingyin Tao, Gergely Zahoránszky-Kőhalmi, Xin Hu, Xin Xu, David Maloney, Alexey V Zakharov, Ganesha Rai, Fumihiko Urano, Mikko Airavaara, Oksana Gavrilova, Ajit Jadhav, Yun Wang, Anton Simeonov, Brandon K Harvey. A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. Cell reports. 2021 04; 35(4):109040. doi: 10.1016/j.celrep.2021.109040. [PMID: 33910017]
  • Boshi Huang, Xinhao Liu, Ye Tian, Dongwei Kang, Zhongxia Zhou, Dirk Daelemans, Erik De Clercq, Christophe Pannecouque, Peng Zhan, Xinyong Liu. First discovery of a potential carbonate prodrug of NNRTI drug candidate RDEA427 with submicromolar inhibitory activity against HIV-1 K103N/Y181C double mutant strain. Bioorganic & medicinal chemistry letters. 2018 05; 28(8):1348-1351. doi: 10.1016/j.bmcl.2018.03.012. [PMID: 29534929]
  • Makoto Miyazaki, Chisako Nishimura, Minori Minamida, Kazunori Iwanaga, Masawo Kakemi. Pharmacokinetic assessment of absorptive interaction of oral etoposide and morphine in rats. Biological & pharmaceutical bulletin. 2014; 37(3):371-7. doi: 10.1248/bpb.b13-00716. [PMID: 24351551]
  • T K Shaughnessy, K J Larson, J S Polakowski, R L Martin. Pharmacological comparison of peristaltic effects in rats and mice. Journal of pharmacological and toxicological methods. 2013 May; 67(3):129-33. doi: 10.1016/j.vascn.2013.02.001. [PMID: 23403246]
  • Yasuto Kido, Pär Matsson, Kathleen M Giacomini. Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2. Journal of medicinal chemistry. 2011 Jul; 54(13):4548-58. doi: 10.1021/jm2001629. [PMID: 21599003]
  • Sivakumar Sathasivam. Current and emerging treatments for the management of myasthenia gravis. Therapeutics and clinical risk management. 2011; 7(?):313-23. doi: 10.2147/tcrm.s14015. [PMID: 21845054]
  • Manoj K Poonia, Ginpreet Kaur, Meena Chintamaneni, Ilesh Changela. New insights into molecular targets for urinary incontinence. Indian journal of pharmacology. 2010 Oct; 42(5):261-6. doi: 10.4103/0253-7613.69980. [PMID: 21206614]
  • I Massarelli, M Macchia, F Minutolo, G Prota, A M Bianucci. QSAR models for predicting enzymatic hydrolysis of new chemical entities in 'soft-drug' design. Bioorganic & medicinal chemistry. 2009 May; 17(10):3543-56. doi: 10.1016/j.bmc.2009.04.014. [PMID: 19398207]
  • Erika Sugiyama, Makoto Inada, Jun-Ichi Kunizaki, Kazuki Tobita, Takahito Yoshida, Minoru Kashimoto, Yukihiro Hirao, Hitoshi Sato. Desirable pharmacokinetic properties of (13)C-uracil as a breath test probe of gastric emptying in comparison with (13)C-acetate and (13)C-octanoate in rats. Scandinavian journal of gastroenterology. 2009; 44(9):1067-75. doi: 10.1080/00365520903114904. [PMID: 19585373]
  • Rebecca J Syed Sheriff, Katie Au, Caroline Cahill, Lorna Duggan, Yanling He, Victor Udu, Jun Xia. Pharmacological interventions for clozapine-induced hypersalivation. Schizophrenia bulletin. 2008 Jul; 34(4):611-2. doi: 10.1093/schbul/sbn043. [PMID: 18495644]
  • Susumu Nakade, Tomoya Ohno, Kazuki Nakayama, Junsaku Kitagawa, Yoshitaka Hashimoto, Akihiro Ohnishi, Yasuyuki Miyata. No effect of imidafenacin, a novel antimuscarinic drug, on digoxin pharmacokinetics in healthy subjects. Drug metabolism and pharmacokinetics. 2008; 23(2):95-100. doi: 10.2133/dmpk.23.95. [PMID: 18445988]
  • Jan I Freijer, Teun M Post, Bart A Ploeger, Joost DeJongh, Meindert Danhof. Application of the convection-dispersion equation to modelling oral drug absorption. Bulletin of mathematical biology. 2007 Jan; 69(1):181-95. doi: 10.1007/s11538-006-9122-8. [PMID: 17024551]
  • Lenika Sagar, Rajesh Sehgal, Sudarshan Ojha. Evaluation of antimotility effect of Lantana camara L. var. acuelata constituents on neostigmine induced gastrointestinal transit in mice. BMC complementary and alternative medicine. 2005 Sep; 5(?):18. doi: 10.1186/1472-6882-5-18. [PMID: 16168064]
  • David Rp Guay. Trospium chloride: an update on a quaternary anticholinergic for treatment of urge urinary incontinence. Therapeutics and clinical risk management. 2005 Jun; 1(2):157-67. doi: 10.2147/tcrm.1.2.157.62912. [PMID: 18360555]
  • Maria Elena Dell'Aquila, Maud Caillaud, Filippo Maritato, Alain Martoriati, Nadine Gérard, Giulio Aiudi, Paolo Minoia, Ghylène Goudet. Cumulus expansion, nuclear maturation and connexin 43, cyclooxygenase-2 and FSH receptor mRNA expression in equine cumulus-oocyte complexes cultured in vitro in the presence of FSH and precursors for hyaluronic acid synthesis. Reproductive biology and endocrinology : RB&E. 2004 Jun; 2(?):44. doi: 10.1186/1477-7827-2-44. [PMID: 15212696]
  • David R P Guay. Clinical pharmacokinetics of drugs used to treat urge incontinence. Clinical pharmacokinetics. 2003; 42(14):1243-85. doi: 10.2165/00003088-200342140-00004. [PMID: 14606931]
  • Mahmood S Mozaffari, James L Borke. Taurine in submandibular gland of the rat: effect of muscarinic drugs. The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society. 2002 Apr; 50(4):527-32. doi: 10.1177/002215540205000409. [PMID: 11897805]
  • P H Marathe, Y Wen, J Norton, D S Greene, R H Barbhaiya, I R Wilding. Effect of altered gastric emptying and gastrointestinal motility on metformin absorption. British journal of clinical pharmacology. 2000 Oct; 50(4):325-32. doi: 10.1046/j.1365-2125.2000.00264.x. [PMID: 11012555]
  • R He, D Q Craig. Characterization of the effects of drug addition on the structure of glyceryl monoolein/water gel systems using low frequency dielectric spectroscopy. Journal of pharmaceutical sciences. 1999 Jun; 88(6):635-9. doi: 10.1021/js980251u. [PMID: 10350501]
  • K Peuhkuri, H Vapaatalo, R Nevala, R Korpela. Influence of the pharmacological modification of gastric emptying on lactose digestion and gastrointestinal symptoms. Alimentary pharmacology & therapeutics. 1999 Jan; 13(1):81-6. doi: 10.1046/j.1365-2036.1999.00450.x. [PMID: 9892883]
  • S Haruta, N Iwasaki, K Ogawara, K Higaki, T Kimura. Absorption behavior of orally administered drugs in rats treated with propantheline. Journal of pharmaceutical sciences. 1998 Sep; 87(9):1081-5. doi: 10.1021/js980117+. [PMID: 9724558]
  • G M Coombes, R J Millard. Urinary urge incontinence: randomised crossover trials of penthienate versus placebo and propantheline. The Medical journal of Australia. 1996 Nov; 165(9):473-6. doi: 10.5694/j.1326-5377.1996.tb138610.x. [PMID: 8937366]
  • P S Heckerling, K A Ammar. Bromide intoxication due to propantheline bromide. American journal of nephrology. 1996; 16(6):537-9. doi: 10.1159/000169056. [PMID: 8955768]
  • S E Bellibaş, I Tuğlular, A Kayali. The effect of delayed gastric emptying and absorption on pharmacokinetic parameters of lithium. European journal of drug metabolism and pharmacokinetics. 1995 Apr; 20(2):129-33. doi: 10.1007/bf03226367. [PMID: 8582438]
  • R D Hernandez, R S Hurwitz, J E Foote, P E Zimmern, G E Leach. Nonsurgical management of threatened upper urinary tracts and incontinence in children with myelomeningocele. The Journal of urology. 1994 Nov; 152(5 Pt 1):1582-5. doi: 10.1016/s0022-5347(17)32480-1. [PMID: 7933209]
  • U A Shukla, K A Pittman, R H Barbhaiya. Pharmacokinetic interactions of cefprozil with food, propantheline, metoclopramide, and probenecid in healthy volunteers. Journal of clinical pharmacology. 1992 Aug; 32(8):725-31. doi: 10.1002/j.1552-4604.1992.tb03876.x. [PMID: 1487562]
  • D K Sommers, E C Meyer, M Van Wyk, J Moncrieff, J R Snyman, R J Grimbeek. The influence of codeine, propantheline and metoclopramide on small bowel transit and theophylline absorption from a sustained-release formulation. British journal of clinical pharmacology. 1992 Mar; 33(3):305-8. doi: 10.1111/j.1365-2125.1992.tb04040.x. [PMID: 1576052]
  • Y Imamura, S Uchiyama, M Otagiri. Opposite effects of metoclopramide and propantheline on intestinal absorption of imipramine in rats. Journal of pharmacobio-dynamics. 1991 Feb; 14(2):66-71. doi: 10.1248/bpb1978.14.66. [PMID: 1870075]
  • G S Hughes, D L Heald, R Patel, C R Spillers, D H Batts, A R Euler. Gastric emptying and the pharmacokinetics of the cephalosporin antibiotic, cefpodoxime proxetil. Methods and findings in experimental and clinical pharmacology. 1990 Apr; 12(3):197-204. doi: NULL. [PMID: 2352449]
  • J Sánchez, L Martínez, J García-Barbal, R Roser, A Bartlett, R Sagarra. The influence of gastric emptying on droxicam pharmacokinetics. Journal of clinical pharmacology. 1989 Aug; 29(8):739-45. doi: 10.1002/j.1552-4604.1989.tb03409.x. [PMID: 2778095]
  • H Saitoh, M Ebina, S Fukuda, K Iseki, K Miyazaki, T Arita. Involvement of sialic acid in high-affinity binding of quaternary ammonium compounds by brush border membrane from rat intestine. The Journal of pharmacy and pharmacology. 1989 Jul; 41(7):459-63. doi: 10.1111/j.2042-7158.1989.tb06500.x. [PMID: 2570850]
  • J K Dunnick, M R Elwell. Toxicity studies of amphetamine sulfate, ampicillin trihydrate, codeine, 8-methoxypsoralen, alpha-methyldopa, penicillin VK and propantheline bromide in rats and mice. Toxicology. 1989 Jun; 56(2):123-36. doi: 10.1016/0300-483x(89)90127-3. [PMID: 2499954]
  • L H Nie, W L Ma, X C Xiang, S Z Yao. [Characteristics of ion selective electrodes with hetero-poly anion sites]. Yao xue xue bao = Acta pharmaceutica Sinica. 1989; 24(6):458-64. doi: . [PMID: 2609985]
  • C T Richardson, C C Barnett, J H Walsh, M Feldman. Comparison of two antimuscarinic drugs, pirenzepine and propantheline, on gastric acid secretion, serum gastrin concentration, salivary flow and heart rate in patients with duodenal ulcer disease. Alimentary pharmacology & therapeutics. 1987 Aug; 1(4):281-91. doi: 10.1111/j.1365-2036.1987.tb00628.x. [PMID: 2979673]
  • J H Adams, G Irving, J H Koeslag, J D Lochner, R C Sandell, C Wilkinson. Beta-adrenergic blockade restores glucose's antiketogenic activity after exercise in carbohydrate-depleted athletes. The Journal of physiology. 1987 May; 386(?):439-54. doi: 10.1113/jphysiol.1987.sp016543. [PMID: 3316599]
  • D D Brown, J Schmid, R A Long, J H Hull. A steady-state evaluation of the effects of propantheline bromide and cholestyramine on the bioavailability of digoxin when administered as tablets or capsules. Journal of clinical pharmacology. 1985 Jul; 25(5):360-4. doi: 10.1002/j.1552-4604.1985.tb02855.x. [PMID: 4031112]
  • P F D'Arcy. Nitrofurantoin. Drug intelligence & clinical pharmacy. 1985 Jul; 19(7-8):540-7. doi: 10.1177/106002808501900706. [PMID: 3896715]
  • A R Mundy. The unstable bladder. Clinics in obstetrics and gynaecology. 1985 Jun; 12(2):431-48. doi: NULL. [PMID: 4028610]
  • S R Cox, E L Harrington, V J Capponi. Bioavailability studies with ciglitazone in beagles. II. Effect of propantheline bromide and metoclopramide HCL on bioavailability of a tablet. Biopharmaceutics & drug disposition. 1985 Jan; 6(1):81-90. doi: 10.1002/bdd.2510060110. [PMID: 3986303]
  • J C Wang. [Effect of Chinese herbal medicine, western medicine and Chinese and western medicine combined in the treatment of peptic ulcer]. Zhong xi yi jie he za zhi = Chinese journal of modern developments in traditional medicine. 1985 Jan; 5(1):20-2, 2. doi: ". [PMID: 3156679]
  • R T Jensen, M J Collen, K E McArthur, J M Howard, P N Maton, J A Cherner, J D Gardner. Comparison of the effectiveness of ranitidine and cimetidine in inhibiting acid secretion in patients with gastric hypersecretory states. The American journal of medicine. 1984 Nov; 77(5B):90-105. doi: NULL. [PMID: 6150641]
  • B Kennedy, D S Janowsky, S C Risch, M G Ziegler. Central cholinergic stimulation causes adrenal epinephrine release. The Journal of clinical investigation. 1984 Sep; 74(3):972-5. doi: 10.1172/jci111517. [PMID: 6470148]
  • M Borzyskowski. Management of neuropathic bladder in childhood. Developmental medicine and child neurology. 1984 Jun; 26(3):401-4. doi: 10.1111/j.1469-8749.1984.tb04460.x. [PMID: 6734958]
  • B G Charles, P J Ravenscroft, N W Jacobsen. Analysis of propantheline bromide in serum by high-performance liquid chromatography. Journal of chromatography. 1984 Mar; 306(?):424-8. doi: 10.1016/s0378-4347(00)80910-x. [PMID: 6715483]
  • K H Donn, F N Eshelman, J R Plachetka, L Fabre, J R Powell. The effects of antacid and propantheline on the absorption of oral ranitidine. Pharmacotherapy. 1984 Mar; 4(2):89-92. doi: 10.1002/j.1875-9114.1984.tb03326.x. [PMID: 6326064]
  • G V Rigby, C W Vose, N J Haskins, E F Allan, I R Harrison, J R Shelton, R D Brownsill, R M Perkins, G C Ford, A J Hawkins. Propantheline bromide plasma level, urinary excretion and pharmacological data in a comparison of the bioavailability of three oral formulations of Pro-Banthine. European journal of drug metabolism and pharmacokinetics. 1983 Jul; 8(3):219-24. doi: 10.1007/bf03188751. [PMID: 6689152]
  • J Y Zhang. [Clinical and experimental observations on chronic bronchitis treated with pukeling]. Zhonghua jie he he hu xi xi ji bing za zhi = Chinese journal of tuberculosis and respiratory diseases. 1983 Jun; 6(3):169-70. doi: ". [PMID: 6653271]
  • R H Briant, R E Dorrington, D G Ferry, J W Paxton. Bioavailability of metoprolol in young adults and the elderly, with additional studies on the effects of metoclopramide and probanthine. European journal of clinical pharmacology. 1983; 25(3):353-6. doi: 10.1007/bf01037947. [PMID: 6628522]
  • D G Kelly, L J Miller, J R Malagelada, K A Huizenga, H Markowitz. Giant hypertrophic gastropathy (Ménétrier's disease): pharmacologic effects on protein leakage and mucosal ultrastructure. Gastroenterology. 1982 Sep; 83(3):581-9. doi: 10.1016/s0016-5085(82)80193-5. [PMID: 6124476]
  • R M Levin, A J Wein. Direct measurement of the anticholinergic activity of a series of pharmacological compounds on the canine and rabbit urinary bladder. The Journal of urology. 1982 Aug; 128(2):396-8. doi: 10.1016/s0022-5347(17)52944-4. [PMID: 7109119]
  • S Gustavsson, H O Adami, O Björklund, L K Enander, G Lundqvist, L Lööf, A Nordahl. Fasting blood levels of gastrin, somatostatin, and pancreatic polypeptide in peptic ulcer disease. Scandinavian journal of gastroenterology. 1982 Jan; 17(1):81-5. doi: 10.3109/00365528209181048. [PMID: 6127790]
  • S Okabe, K Tabata, M Kawakami. Effects of prolonged treatment of pirenzepine 2HCl on gastric secretion and plasma gastrin levels in rats. Arzneimittel-Forschung. 1982; 32(6):664-8. doi: . [PMID: 6896823]
  • C G Regårdh, P Lundborg, B A Persson. The effect of antacid, metoclopramide, and propantheline on the bioavailability of metoprolol and atenolol. Biopharmaceutics & drug disposition. 1981 Jan; 2(1):79-87. doi: 10.1002/bdd.2510020109. [PMID: 7236872]
  • N S Track, R S McLeod, A V Mee. Human pancreatic polypeptide: studies of fasting and postprandial plasma concentrations. Canadian journal of physiology and pharmacology. 1980 Dec; 58(12):1484-9. doi: 10.1139/y80-223. [PMID: 7237243]
  • S Ljunghall, H O Adami, O Björklund, L K Enander, S Gustavson, L Lööf, A Nordahl, L Wide. Serum concentrations of parathyroid hormone in euparathyroid subjects during cimetidine treatment. The New England journal of medicine. 1980 Nov; 303(20):1178-9. doi: 10.1056/nejm198011133032017. [PMID: 7421938]
  • J G Blaivas. Management of bladder dysfunction in multiple sclerosis. Neurology. 1980 Jul; 30(7 Pt 2):12-8. doi: 10.1212/wnl.30.7_part_2.12. [PMID: 7190251]
  • W C Duane, J H Bond. Prolongation of intestinal transit and expansion of bile acid pools by propantheline bromide. Gastroenterology. 1980 Feb; 78(2):226-30. doi: ". [PMID: 7350044]
  • C W Vose, P M Stevens, N J Haskins, K A Waddell, A J Hawkins, D A Rose, G L Evans, R F Palmer, V Diaz, J Garza, O Martin, H Rudel. Plasma levels and urinary excretion of orally administered propantheline bromide in man. European journal of drug metabolism and pharmacokinetics. 1980; 5(1):29-34. doi: 10.1007/bf03189440. [PMID: 7389749]
  • J R Fliegner, P P Glenning. Seven years experience in the evaluation and management of patients with urge incontinence of urine. The Australian & New Zealand journal of obstetrics & gynaecology. 1979 Feb; 19(1):42-4. doi: 10.1111/j.1479-828x.1979.tb01351.x. [PMID: 292419]
  • C W Vose, M Prout, N J Haskins, C Ford, R F Palmer, M J Tidd. Identification of some urinary metabolites of propantheline bromide in man. Xenobiotica; the fate of foreign compounds in biological systems. 1978 Dec; 8(12):745-52. doi: 10.3109/00498257809069587. [PMID: 726518]
  • E J Burbige, R J Manning, J P Belber. Watery diarrhea syndrome with elevated levels of vasoactive intestinal polypeptide associated with pancreatitis and pancreatic pseudocyst. The American journal of gastroenterology. 1978 Aug; 70(2):136-40. doi: . [PMID: 717364]
  • B Beermann, M Groschinsky-Grind. Enhancement of the gastrointestinal absorption of hydrochlorothiazide by propantheline. European journal of clinical pharmacology. 1978 Jul; 13(5):385-7. doi: 10.1007/bf00644613. [PMID: 668798]
  • B F Johnson, J O'Grady, C Bye. The influence of digoxin particle size on absorption of digoxin and the effect of propantheline and metoclopramide. British journal of clinical pharmacology. 1978 May; 5(5):465-7. doi: 10.1111/j.1365-2125.1978.tb01657.x. [PMID: 656287]
  • R L Smith, D W Powell. Prolonged treatment of menetrier's disease with an oral anticholinergic drug. Gastroenterology. 1978 May; 74(5 Pt 1):903-6. doi: 10.1016/0016-5085(78)90151-8. [PMID: 640345]
  • M B Davidson, A B Forsythe. Dietary and anticholinergic effects on intravenous glucose tolerance and insulin secretion. International journal of obesity. 1978; 2(3):309-20. doi: NULL. [PMID: 721369]
  • G C Ford, S J Grigson, N J Haskins, R F Palmer, M Prout, C W Vose. The measurements of propantheline ion in biological fluids after administering propantheline bromide to man. Biomedical mass spectrometry. 1977 Apr; 4(2):94-7. doi: 10.1002/bms.1200040207. [PMID: 884212]
  • M A Permutt, D Keller, J Santiago. Cholinergic blockade in reactive hypoglycemia. Diabetes. 1977 Feb; 26(2):121-7. doi: 10.2337/diab.26.2.121. [PMID: 838165]
  • E Pedersen. Studies on the effect and mode of action of flavoxate in human urinary bladder and sphincter. Urologia internationalis. 1977; 32(2-3):202-8. doi: 10.1159/000280131. [PMID: 906183]
  • R P Beck, D Arnusch, C King. Results in treating 210 patients with detrusor overactivity incontinence of urine. American journal of obstetrics and gynecology. 1976 Jul; 125(5):593-6. doi: 10.1016/0002-9378(76)90778-x. [PMID: 779473]
  • A F Ippoliti, J I Isenberg, V Maxwell, J H Walsh. The effect of 16,16-dimethyl prostaglandin E2 on meal-stimulated gastric acid secretion and serum gastrin in duodenal ulcer patients. Gastroenterology. 1976 Apr; 70(4):488-91. doi: 10.1016/s0016-5085(76)80483-0. [PMID: 1254135]
  • J M Jaffe. Effect of propantheline on nitrofurantoin absorption. Journal of pharmaceutical sciences. 1975 Oct; 64(10):1729-30. doi: 10.1002/jps.2600641039. [PMID: 1185550]
  • G J Krejs, C Horica, I Benes, A L Blum. [Modified Cr51-chromium-albumin test for the differential diagnosis of exudative gastropathies and enteropathies]. Schweizerische medizinische Wochenschrift. 1975 Sep; 105(36):1135-7. doi: NULL. [PMID: 1215894]
  • U W Wiegand, H G Weder, R Haller. [Studies on the binding of some parasympatholytics to bovine serum albumin/measurement of relaxation times (author's transl)]. Arzneimittel-Forschung. 1975 Jul; 25(7):1008-12. doi: NULL. [PMID: 241353]
  • U W Wiegand, H G Weder, R Haller. [Interactions of some parasympatholytics and structurally similar drugs with bovine serum albumin]. Arzneimittel-Forschung. 1975 Jun; 25(6):839-43. doi: NULL. [PMID: 240366]
  • N G Graham. Acute pancreatitis. The Practitioner. 1975 Jun; 214(1284):763-75. doi: NULL. [PMID: 1079943]
  • J L Crammer, R M Rosser, G Crane. Blood levels and management of lithium treatment. British medical journal. 1974 Sep; 3(5932):650-4. doi: 10.1136/bmj.3.5932.650. [PMID: 4425791]
  • D F Evered, J M McMullen. Letter: Drugs and xylose absorption from intestine. British medical journal. 1974 Jun; 2(5921):728-9. doi: 10.1136/bmj.2.5921.728-d. [PMID: 4852760]
  • N K Sarin, Y P Bhandari. Letter: Intravenous pyelography after probanthine. Indian journal of medical sciences. 1974 Feb; 28(2):125. doi: NULL. [PMID: 4839559]
  • D Westerlund, K H Karset. Fluorimetric determination of propantheline in human blood plasma by an ion-pair extraction method. Analytica chimica acta. 1973 Nov; 67(1):99-106. doi: 10.1016/s0003-2670(01)80236-1. [PMID: 4759897]
  • J J Ashley, G Levy. Effect of vehicle viscosity and an anticholinergic agent on bioavailability of a poorly absorbed drug (phenolsulfonphthalein) in man. Journal of pharmaceutical sciences. 1973 Apr; 62(4):688-90. doi: 10.1002/jps.2600620436. [PMID: 4698998]
  • J Nimmo, R C Heading, P Tothill, L F Prescott. Pharmacological modification of gastric emptying: effects of propantheline and metoclopromide on paracetamol absorption. British medical journal. 1973 Mar; 1(5853):587-9. doi: 10.1136/bmj.1.5853.587. [PMID: 4694406]
  • G Levy, M Gibaldi, J A Procknal. Effect of an anticholinergic agent on riboflavin absorption in man. Journal of pharmaceutical sciences. 1972 May; 61(5):798-9. doi: 10.1002/jps.2600610529. [PMID: 4556316]
  • B Beermann, K Hellström, A Rosèn. On the metabolism of propantheline in man. Clinical pharmacology and therapeutics. 1972 Mar; 13(2):212-20. doi: 10.1002/cpt1972132212. [PMID: 4553892]
  • L A Hadwiger. Increased levels of pisatin and phenylalanine ammonia lyase activity in Pisum sativum treated with antihistaminic, antiviral, antimalarial, tranquilizing, or other drugs. Biochemical and biophysical research communications. 1972 Jan; 46(1):71-9. doi: 10.1016/0006-291x(72)90631-6. [PMID: 4399452]
  • J A Antonioli, J L Schelling, E Steininger, G A Borel. Effect of gastrectomy and of an anticholinergic drug on the gastrointestinal absorption of a sulfonamide in man. Internationale Zeitschrift fur klinische Pharmakologie, Therapie, und Toxikologie. International journal of clinical pharmacology, therapy, and toxicology. 1971 Oct; 5(2):212-5. doi: NULL. [PMID: 4944097]
  • H J Roberts. Hypertrophic gastropathy with hypersecretion and gastric protein loss. Australian and New Zealand journal of medicine. 1971 Feb; 1(1):69-71. doi: 10.1111/j.1445-5994.1971.tb02265.x. [PMID: 5284087]
  • T Moore. The management of incontinence of urine in neurological disorders. Bibliotheca psychiatrica et neurologica. 1969; 139(?):164-73. doi: 10.1159/000385705. [PMID: 5406901]
  • M Pfeffer, J M Schor, S Bolton, R Jacobsen. Human urinary excretion of the quaternary ammonium compounds anisotropine methylbromide and propantheline bromide. Journal of pharmaceutical sciences. 1968 Aug; 57(8):1375-8. doi: 10.1002/jps.2600570821. [PMID: 5695651]
  • W G Nayler, I McInnes, J B Swann, J M Price, V Carson, D Race, T E Lowe. Some effects of iproveratril (Isoptin) on the cardiovascular system. The Journal of pharmacology and experimental therapeutics. 1968 Jun; 161(2):247-61. doi: NULL. [PMID: 5650138]
  • F G SMITH, N LITMAN, H LATTA. LUPUS GLOMERULONEPHRITIS. THE EFFECT OF LARGE DOSES OF CORTICOSTEROIDS ON RENAL FUNCTION AND RENAL LESIONS IN TWO CHILDREN. American journal of diseases of children (1960). 1965 Sep; 110(?):302-8. doi: NULL. [PMID: 14332367]
  • C CRAIG, R E GRANT, E GILFORD, D A HUTCHINSON. The use of probanthine in attempts to visualise the lower ureters during intravenous pyelography. Journal of the College of Radiologists of Australasia. 1961 Dec; 5(?):85-7. doi: 10.1111/j.1440-1673.1961.tb03378.x. [PMID: 13881953]